pimagedine has been researched along with Body Weight in 72 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study was to investigate the potential protective effect of l-arginine (Arg; nitric oxide precursor) and aminoguanidine (inducible nitric oxide synthase inhibitor) against acetic acid (AA)-induced colitis in rats, and the potential role of NF-κB." | 7.80 | L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-κB/p65. ( Farghaly, HS; Thabit, RH, 2014) |
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 7.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| " The aim of the present study was to investigate the potential protective effect of l-arginine (Arg; nitric oxide precursor) and aminoguanidine (inducible nitric oxide synthase inhibitor) against acetic acid (AA)-induced colitis in rats, and the potential role of NF-κB." | 3.80 | L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-κB/p65. ( Farghaly, HS; Thabit, RH, 2014) |
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 3.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| "Cataract formation occurred after 13 weeks in diabetic animals compared with 17 weeks for those treated with aminoguanidine, and 16 weeks for those treated with probucol (p < 0." | 3.70 | Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. ( Agardh, C; Agardh, E; Hultberg, B, 2000) |
| " Using NG-nitro-L-arginine methyl ester, an inhibitor of both the constitutive and the cytokine inducible forms of nitric oxide synthase, and aminoguanidine, a preferential inhibitor of the inducible form of nitric oxide synthase, we investigated the impact of inhibiting nitric oxide production on food-intake, body weight and temperature, blood glucose, plasma insulin, glucagon, corticosterone and leukocyte- and differential-counts in normal rats injected once daily for 5 days with interleukin 1 beta (IL-1 beta) (0." | 3.69 | Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases. ( Bjerre, U; Mandrup-Poulsen, T; Nerup, J; Reimers, JI, 1994) |
| "Administration of the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) during pregnancy has been shown to compromise fetal growth." | 3.69 | Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats. ( Clark, DA; Eloby-Childress, S; Miller, MJ; Pierce, MR; Voelker, CA; Zhang, XJ, 1995) |
| "Iodoacetamide treatment up-regulated the expression of iNOS mRNA and NO production in the stomach, without affecting nNOS expression." | 1.33 | Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment. ( Hayashi, Y; Nishio, H; Takeuchi, K; Terashima, S, 2006) |
| "We investigated the hypothesis that cardiac hypertrophy due to volume overload produces changes in myocardial diastolic mechanics and stiffness that are in part due to alterations in advanced glycation end-product (AGE) collagen cross-linking." | 1.32 | Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. ( Herrmann, KL; McCulloch, AD; Omens, JH, 2003) |
| "The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent." | 1.31 | ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. ( Cooper, ME; Davis, B; Jaworski, K; Kelly, DJ; Koerner, SM; Thallas, V; Wilkinson-Berka, JL, 2002) |
| "2." | 1.31 | The lung is the major site that produces nitric oxide to induce acute pulmonary oedema in endotoxin shock. ( Chen, HI; Kao, SJ; Lee, RP; Wang, D, 2001) |
| "Cataract was observed in all six of the surviving rats in Groups 2 and 4, and in one of 6 surviving rats in group 3." | 1.31 | Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats. ( Azal, O; Baydar, A; Cakir, B; Corakçi, A; Güler, S; Kutlu, M; Yönem, A, 2002) |
| " This study investigated the effect of chronic administration of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to portal hypertensive rats on hemodynamics and the development of portal hypertensive gastropathy." | 1.30 | Aminoguanidine corrects hyperdynamic circulation without ameliorating portal hypertension and portal hypertensive gastropathy in anesthetized portal hypertensive rats. ( Chu, CJ; Lee, FY; Lee, SD; Lin, HC; Lin, HJ; Tai, CC; Tsai, YT; Wang, SS; Wu, SL, 1997) |
| "Hemorrhage is a major pathological manifestation of E." | 1.30 | Nitric oxide production during Eimeria tenella infections in chickens. ( Allen, PC, 1997) |
| "Although sepsis is known to affect vascular function, little is known about changes at the capillary level." | 1.30 | Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis. ( McCormack, DG; Tyml, K; Yu, J, 1998) |
| "Malondialdehyde (MDA) content was significantly elevated and activities of SOD and catalase decreased in the kidneys of STZ-diabetic rats." | 1.30 | Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney. ( Kedziora-Kornatowska, K; Luciak, M, 1998) |
| " In this study, we show that the development of diabetes, measured by increased water intake and concomitant midday blood glucose levels in type II genetically diabetic mice, is reduced by treatment with aminoguanidine at a dosage of 500 mg/kg/d for 12 weeks in the diet." | 1.30 | Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. ( Piercy, V; Toseland, CD; Turner, NC, 1998) |
| "Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR." | 1.29 | Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.17) | 18.7374 |
| 1990's | 38 (52.78) | 18.2507 |
| 2000's | 26 (36.11) | 29.6817 |
| 2010's | 4 (5.56) | 24.3611 |
| 2020's | 1 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, TFO | 1 |
| Costa, MC | 1 |
| Figueiredo, ID | 1 |
| Inácio, MD | 1 |
| Rodrigues, MR | 1 |
| Assis, RP | 1 |
| Baviera, AM | 1 |
| Brunetti, IL | 1 |
| Radika, MK | 1 |
| Viswanathan, P | 1 |
| Anuradha, CV | 1 |
| Farghaly, HS | 1 |
| Thabit, RH | 1 |
| Gül, M | 1 |
| Emre, S | 1 |
| Eşrefoğlu, M | 1 |
| Vard, N | 1 |
| Yan, H | 1 |
| Guo, Y | 1 |
| Zhang, J | 1 |
| Ding, Z | 1 |
| Ha, W | 1 |
| Harding, JJ | 1 |
| Lee, YK | 1 |
| Lee, JY | 1 |
| Kim, JS | 1 |
| Won, KB | 1 |
| Kang, HJ | 1 |
| Jang, TJ | 1 |
| Tak, WT | 1 |
| Lee, JH | 1 |
| Ito, J | 1 |
| Uchida, H | 1 |
| Yokote, T | 1 |
| Ohtake, K | 1 |
| Kobayashi, J | 1 |
| Ribeiro, DE | 1 |
| Maiolini, VM | 1 |
| Soncini, R | 1 |
| Antunes-Rodrigues, J | 1 |
| Elias, LL | 1 |
| Vilela, FC | 1 |
| Giusti-Paiva, A | 1 |
| Miyoshi, H | 1 |
| Taguchi, T | 2 |
| Sugiura, M | 2 |
| Takeuchi, M | 1 |
| Yanagisawa, K | 1 |
| Watanabe, Y | 1 |
| Miwa, I | 2 |
| Makita, Z | 2 |
| Koike, T | 2 |
| Wilkinson-Berka, JL | 1 |
| Kelly, DJ | 1 |
| Koerner, SM | 1 |
| Jaworski, K | 1 |
| Davis, B | 1 |
| Thallas, V | 2 |
| Cooper, ME | 4 |
| Herrmann, KL | 1 |
| McCulloch, AD | 1 |
| Omens, JH | 1 |
| Chen, AS | 1 |
| Aoyama, S | 1 |
| Haruna, M | 1 |
| Wang, MW | 1 |
| Zhao, P | 1 |
| Zuo, Z | 1 |
| Rodríguez-Gómez, I | 1 |
| Wangensteen, R | 1 |
| Moreno, JM | 1 |
| Chamorro, V | 1 |
| Osuna, A | 1 |
| Vargas, F | 1 |
| Lee, YM | 1 |
| Cheng, PY | 1 |
| Hong, SF | 1 |
| Chen, SY | 1 |
| Lam, KK | 1 |
| Sheu, JR | 1 |
| Yen, MH | 1 |
| Nishio, H | 1 |
| Hayashi, Y | 1 |
| Terashima, S | 1 |
| Takeuchi, K | 1 |
| Chang, KC | 1 |
| Tseng, CD | 1 |
| Wu, MS | 1 |
| Liang, JT | 1 |
| Tsai, MS | 1 |
| Cho, YL | 1 |
| Tseng, YZ | 1 |
| Millerot-Serrurot, E | 1 |
| Chausset, A | 1 |
| Mossiat, C | 1 |
| Prigent-Tessier, A | 1 |
| Bertrand, N | 1 |
| Garnier, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Jeyabal, PV | 1 |
| Kumar, R | 1 |
| Gangula, PR | 1 |
| Micci, MA | 1 |
| Pasricha, PJ | 1 |
| Wang, D | 2 |
| An, SC | 1 |
| Zhang, X | 1 |
| Sugiyama, T | 2 |
| Suguro, N | 1 |
| Hayashida, A | 1 |
| Reimers, JI | 1 |
| Bjerre, U | 1 |
| Mandrup-Poulsen, T | 1 |
| Nerup, J | 1 |
| Hammes, HP | 1 |
| Strödter, D | 1 |
| Weiss, A | 1 |
| Bretzel, RG | 1 |
| Federlin, K | 1 |
| Brownlee, M | 1 |
| Tilton, RG | 2 |
| Chang, K | 2 |
| Hasan, KS | 1 |
| Smith, SR | 1 |
| Petrash, JM | 1 |
| Misko, TP | 1 |
| Moore, WM | 1 |
| Currie, MG | 1 |
| Corbett, JA | 1 |
| McDaniel, ML | 1 |
| Marx, M | 1 |
| Trittenwein, G | 1 |
| Aufricht, C | 1 |
| Hoeger, H | 1 |
| Lubec, B | 1 |
| Soulis-Liparota, T | 1 |
| Dunlop, M | 1 |
| Jerums, G | 3 |
| Way, KJ | 1 |
| Reid, JJ | 1 |
| Voelker, CA | 1 |
| Miller, MJ | 1 |
| Zhang, XJ | 1 |
| Eloby-Childress, S | 1 |
| Clark, DA | 1 |
| Pierce, MR | 1 |
| Hoffman, RA | 2 |
| Langrehr, JM | 2 |
| Berry, LM | 1 |
| White, DA | 1 |
| Schattenfroh, NC | 1 |
| McCarthy, SA | 1 |
| Simmons, RL | 2 |
| Li, YM | 1 |
| Steffes, M | 1 |
| Donnelly, T | 1 |
| Liu, C | 1 |
| Fuh, H | 1 |
| Basgen, J | 1 |
| Bucala, R | 1 |
| Vlassara, H | 1 |
| Miyauchi, Y | 1 |
| Shikama, H | 1 |
| Takasu, T | 1 |
| Okamiya, H | 1 |
| Umeda, M | 1 |
| Hirasaki, E | 1 |
| Ohhata, I | 1 |
| Nakayama, H | 1 |
| Nakagawa, S | 1 |
| Yildiz, O | 1 |
| Ozata, M | 1 |
| Ozkardeş, A | 1 |
| Deniz, G | 1 |
| Yildirimkaya, M | 1 |
| Corakçi, A | 2 |
| Yardim, M | 1 |
| Gündoğan, MA | 1 |
| Tsukahara, H | 1 |
| Miura, M | 1 |
| Tsuchida, S | 1 |
| Hata, I | 1 |
| Hata, K | 1 |
| Yamamoto, K | 1 |
| Ishii, Y | 1 |
| Muramatsu, I | 1 |
| Sudo, M | 1 |
| Nyengaard, JR | 1 |
| Berhorst, S | 1 |
| Reiser, KM | 1 |
| Williamson, JR | 1 |
| Nüssler, NC | 1 |
| Gleixner, SL | 1 |
| Zhang, G | 1 |
| Ford, HR | 1 |
| Demetris, AJ | 1 |
| Dewhurst, M | 1 |
| Omawari, N | 1 |
| Tomlinson, DR | 1 |
| Rumble, JR | 1 |
| Soulis, T | 2 |
| Cox, A | 1 |
| Wu, L | 1 |
| Youssef, S | 2 |
| Jasik, M | 1 |
| Gilbert, RE | 2 |
| Yamauchi, A | 1 |
| Takei, I | 1 |
| Nakamoto, S | 1 |
| Ohashi, N | 1 |
| Kiguchi, H | 1 |
| Ishii, T | 1 |
| Saruta, T | 1 |
| Lee, FY | 1 |
| Wang, SS | 1 |
| Tsai, YT | 1 |
| Lin, HJ | 1 |
| Lin, HC | 1 |
| Chu, CJ | 1 |
| Wu, SL | 1 |
| Tai, CC | 1 |
| Lee, SD | 1 |
| Allen, PC | 1 |
| McWilliam, BG | 1 |
| Murray-McIntosh, RP | 1 |
| Tyml, K | 1 |
| Yu, J | 1 |
| McCormack, DG | 1 |
| Agardh, CD | 1 |
| Agardh, E | 2 |
| Hultberg, B | 2 |
| Qian, Y | 1 |
| Ostenson, CG | 1 |
| Ino-ue, M | 1 |
| Ohgiya, N | 1 |
| Yamamoto, M | 1 |
| Yang, CW | 1 |
| Yu, CC | 1 |
| Ko, YC | 1 |
| Huang, CC | 1 |
| Kedziora-Kornatowska, K | 1 |
| Luciak, M | 3 |
| Kedziora-Kornatowska, KZ | 2 |
| Blaszczyk, J | 1 |
| Pawlak, W | 2 |
| Piercy, V | 1 |
| Toseland, CD | 1 |
| Turner, NC | 1 |
| Błaszczyk, J | 1 |
| Yamada, S | 1 |
| Ohkubo, C | 1 |
| Iqbal, M | 1 |
| Probert, LL | 1 |
| Alhumadi, NH | 1 |
| Klandorf, H | 1 |
| Sugimoto, H | 1 |
| Shikata, K | 1 |
| Wada, J | 1 |
| Horiuchi, S | 1 |
| Makino, H | 1 |
| Iskit, AB | 1 |
| Sungur, A | 1 |
| Gedikoglu, G | 1 |
| Guc, MO | 1 |
| Mayhan, WG | 1 |
| Sharpe, GM | 1 |
| Unlüçerçi, Y | 2 |
| Bekpinar, S | 2 |
| Koçak, H | 1 |
| Agardh, C | 1 |
| Kagota, S | 1 |
| Yamaguchi, Y | 1 |
| Nakamura, K | 1 |
| Kunitomo, M | 1 |
| Lee, RP | 1 |
| Kao, SJ | 1 |
| Chen, HI | 1 |
| Osicka, TM | 1 |
| Kiriazis, Z | 1 |
| Pratt, LM | 1 |
| Comper, WD | 1 |
| El-Khatib, AS | 1 |
| Moustafa, AM | 1 |
| Abdel-Aziz, AA | 1 |
| Al-Shabanah, OA | 1 |
| El-Kashef, HA | 1 |
| Ozyazgan, S | 1 |
| Akkan, AG | 1 |
| Cantini, C | 1 |
| Kieffer, P | 1 |
| Corman, B | 1 |
| Limiñana, P | 1 |
| Atkinson, J | 1 |
| Lartaud-Idjouadiene, I | 1 |
| Azal, O | 1 |
| Yönem, A | 1 |
| Güler, S | 1 |
| Cakir, B | 1 |
| Baydar, A | 1 |
| Kutlu, M | 1 |
| Watanuki, M | 1 |
| Sakai, A | 1 |
| Sakata, T | 1 |
| Tsurukami, H | 1 |
| Miwa, M | 1 |
| Uchida, Y | 1 |
| Watanabe, K | 1 |
| Ikeda, K | 1 |
| Nakamura, T | 1 |
| Bannai, C | 2 |
| Yamazaki, M | 1 |
| Matsushima, Y | 1 |
| Kunika, K | 2 |
| Itakura, M | 2 |
| Okuda, Y | 1 |
| Yamashita, K | 2 |
| Preedy, VR | 2 |
| Hammond, B | 1 |
| Marway, JS | 1 |
| Yagihashi, S | 1 |
| Kamijo, M | 1 |
| Baba, M | 1 |
| Yagihashi, N | 1 |
| Nagai, K | 1 |
| Yoshikawa, H | 1 |
| Kato, M | 1 |
| Kawakami, Y | 1 |
| Yamaoka, T | 1 |
| Kumari, K | 1 |
| Murthy, PS | 1 |
| Sahib, MK | 1 |
| Kusche, J | 1 |
| Mennigen, R | 1 |
| Leisten, L | 1 |
| Amoei, B | 1 |
| Miyamoto, K | 1 |
| Katagiri, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
72 other studies available for pimagedine and Body Weight
| Article | Year |
|---|---|
Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Curcumin; Diabetes Mellitus, Experime | 2020 |
Nitric oxide mediates the insulin sensitizing effects of β-sitosterol in high fat diet-fed rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Diet, High-Fat; Guanidines; Hepatocytes; | 2013 |
L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-κB/p65.
Topics: Acetic Acid; Animals; Arginine; Body Weight; Colitis; Colon; Guanidines; Inflammation; Male; NF-kapp | 2014 |
Protective effects of melatonin and aminoguanidine on the cornea in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Corneal Diseases; Diabetes | 2008 |
Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.
Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Cornea; Diabetes Mellitus, Experi | 2008 |
The breakdown of preformed peritoneal advanced glycation end products by intraperitoneal alagebrium.
Topics: Animals; Biological Transport; Body Weight; Cell Membrane; Glycation End Products, Advanced; Guanidi | 2009 |
Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-{gamma} in rat.
Topics: Animals; Apoptosis; Atrophy; Body Weight; Cell Proliferation; Food Deprivation; Gene Expression Regu | 2010 |
Inhibition of nitric oxide synthase accentuates endotoxin-induced sickness behavior in mice.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Drug Synergism; Eating; Enzyme Inhibitors; E | 2013 |
Aminoguanidine pyridoxal adduct is superior to aminoguanidine for preventing diabetic nephropathy in mice.
Topics: Animals; Azo Compounds; Benzoates; Blood Glucose; Body Weight; Diabetic Nephropathies; Glycation End | 2002 |
ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
Topics: Amides; Animals; Animals, Genetically Modified; Blood Pressure; Body Weight; Diabetes Mellitus, Expe | 2002 |
Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy.
Topics: Animals; Arteriovenous Fistula; Biomechanical Phenomena; Body Weight; Cardiac Volume; Cardiomegaly; | 2003 |
Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine.
Topics: Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Benzoates; Blood Glucose; Body We | 2003 |
Isoflurane preconditioning induces neuroprotection that is inducible nitric oxide synthase-dependent in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Gas Analysis; Blotting, Western; Body Weig | 2004 |
Effects of chronic inhibition of inducible nitric oxide synthase in hyperthyroid rats.
Topics: Animals; Blood Chemical Analysis; Blood Pressure; Body Weight; Enzyme Inhibitors; Guanidines; Heart | 2005 |
Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized rats.
Topics: Animals; Aorta, Thoracic; Body Weight; Cyclic N-Oxides; Enzyme Induction; Estradiol; Female; Glutath | 2005 |
Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment.
Topics: Animals; Body Weight; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastritis; Guanidines; Iodoac | 2006 |
Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cardiac Output; Diabetes Mellitus, Experimental; Diabete | 2006 |
Effect of early decrease in the lesion size on late brain tissue loss, synaptophysin expression and functionality after a focal brain lesion in rats.
Topics: 2,2'-Dipyridyl; Animals; Body Weight; Brain; Brain Ischemia; Cerebral Cortex; Guanidines; Immunohist | 2007 |
Inhibitors of advanced glycation end-products prevent loss of enteric neuronal nitric oxide synthase in diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Duodenum; E | 2008 |
Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor.
Topics: Animals; Appetite; Behavior, Animal; Body Weight; Chronic Disease; Depressive Disorder; Disease Mode | 2008 |
Effects of aminoguanidine sulfate on the incorporation of amino acids and bases into chick embryonic liver and body.
Topics: Amino Acids; Animals; Body Weight; Chick Embryo; Guanidines; Liver; Nucleic Acids; Organ Size; Prote | 1980 |
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Glucose; Body Temperature; Body Weight; Cortico | 1994 |
Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model.
Topics: Administration, Oral; Animals; Arterioles; Blood Glucose; Body Weight; Diabetes Mellitus, Experiment | 1995 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; B | 1993 |
Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice.
Topics: Agmatine; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Guanidines | 1995 |
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydrox | 1995 |
Effect of aminoguanidine on the impaired nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Expe | 1994 |
Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats.
Topics: Animals; Animals, Newborn; Arginine; Body Weight; Disease Models, Animal; Embryonic and Fetal Develo | 1995 |
Bystander injury of host lymphoid tissue during murine graft-verus-host disease is mediated by nitric oxide.
Topics: Animals; Body Weight; Cell Transplantation; Cytotoxicity, Immunologic; Enzyme Inhibitors; Female; Gr | 1996 |
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.
Topics: Acetylcholine; Aging; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Creatinine; Enzyme | 1996 |
Slowing of peripheral motor nerve conduction was ameliorated by aminoguanidine in streptozocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fructo | 1996 |
Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Carnitine; Diabetes Mellitus, Experimental; Diabetic N | 1996 |
Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats.
Topics: Absorptiometry, Photon; Aging; Animals; Blood Pressure; Body Weight; Bone and Bones; Bone Density; E | 1996 |
Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Blood Pressure; Body Weight; Capillaries; Ca | 1997 |
Attenuation of lethal graft-versus-host disease by inhibition of nitric oxide synthase.
Topics: Animals; Body Weight; Bone Marrow; Enzyme Inhibitors; Female; Graft vs Host Disease; Guanidines; Mic | 1997 |
Aminoguanidine--effects on endoneurial vasoactive nitric oxide and on motor nerve conduction velocity in control and streptozotocin-diabetic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Di | 1997 |
Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products.
Topics: Animals; Blotting, Northern; Body Weight; Collagen; Diabetes Mellitus, Experimental; DNA Probes; Ext | 1997 |
Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dise | 1997 |
Aminoguanidine corrects hyperdynamic circulation without ameliorating portal hypertension and portal hypertensive gastropathy in anesthetized portal hypertensive rats.
Topics: Animals; Body Weight; Disease Models, Animal; Enzyme Inhibitors; Gastric Mucosa; Guanidines; Hemodyn | 1997 |
Nitric oxide production during Eimeria tenella infections in chickens.
Topics: Animals; Body Weight; Cecum; Chickens; Coccidiosis; Eimeria tenella; Endothelium, Vascular; Enzyme I | 1997 |
Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cattle; Diabetes Mellitus, Experimental; Diabetic Angiop | 1997 |
Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis.
Topics: Acetylcholine; Animals; Arterioles; Body Weight; Capillaries; Enzyme Inhibitors; Guanidines; Iontoph | 1998 |
The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Reti | 1998 |
Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relation | 1998 |
Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice.
Topics: Animals; Body Weight; Cell Count; Creatine; Crosses, Genetic; Enzyme Inhibitors; Female; Guanidines; | 1998 |
Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Glycate | 1998 |
Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes.
Topics: Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Erythrocytes; Glutat | 1998 |
Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Drinking; Fe | 1998 |
Effect of aminoguanidine on the generation of superoxide anion and nitric oxide by peripheral blood granulocytes of rats with streptozotocin-induced diabetes.
Topics: Animals; Anions; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycated Hemoglobin; G | 1998 |
The influence of frequent and excessive intake of glucose on microvascular aging in healthy mice.
Topics: Aging; Animals; Body Weight; Energy Intake; Enzyme Inhibitors; Glucose; Glycation End Products, Adva | 1999 |
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme | 1999 |
Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructosamin | 1999 |
The effects of bosentan, aminoguanidine and L-canavanine on mesenteric blood flow, spleen and liver in endotoxaemic mice.
Topics: Animals; Antihypertensive Agents; Body Weight; Bosentan; Canavanine; Dose-Response Relationship, Dru | 1999 |
Aminoguanidine suppresses basal macromolecular extravasation during diabetes mellitus.
Topics: Animals; Arterioles; Biological Transport; Blood Glucose; Body Weight; Capillary Permeability; Cheek | 2000 |
Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glycat | 2000 |
Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cataract; Cysteine; Diabetes Mellitus, Experimental; Diabetic R | 2000 |
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents | 2000 |
The lung is the major site that produces nitric oxide to induce acute pulmonary oedema in endotoxin shock.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Dexamethasone; Enzyme Inhibitors; Es | 2001 |
Ramipril and aminoguanidine restore renal lysosomal processing in streptozotocin diabetic rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Body Weight; Chrom | 2001 |
Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Chelating Agents; Deferoxamine; Drug Inte | 2001 |
Impaired relaxation in aorta from streptozotocin-diabetic rats: effect of aminoguanidine (AMNG) treatment.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes | 2000 |
Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats.
Topics: Aging; Animals; Aorta; Aorta, Thoracic; Blood Glucose; Blood Pressure; Body Weight; Calcium; Collage | 2001 |
Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; | 2002 |
Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading.
Topics: Adaptation, Physiological; Alkaline Phosphatase; Animals; Base Sequence; Body Weight; Bone and Bones | 2002 |
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamid | 1992 |
An investigation into the effects of aminoguanidine treatment on the plasma and blood of free-fed and dietary-restricted rats.
Topics: Animals; Blood; Blood Cell Count; Blood Proteins; Body Weight; Diet; Drinking; Electrolytes; Enzymes | 1991 |
The effect of aminoguanidine treatment, with or without food restriction on the liver, stomach and small intestine of the rat.
Topics: Administration, Oral; Animals; Body Weight; DNA; Fasting; Gastric Mucosa; Guanidines; Intestine, Sma | 1991 |
Effect of aminoguanidine on functional and structural abnormalities in peripheral nerve of STZ-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycate | 1992 |
Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, | 1991 |
Monoaminoguanidine prevents sorbitol accumulation, nonenzymatic protein glycosylation and development of kidney lesions in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycos | 1991 |
Elevation of the large bowel histamine concentration by aminoguanidine induced diamine oxidase inhibition.
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Body Weight; Guanidines; Histamine | 1987 |
Histological studies on developing chick embryos treated with aminoguanidine sulfate.
Topics: Animals; Body Weight; Chick Embryo; Embryonic and Fetal Development; Guanidines; Liver; Organ Size; | 1985 |