pimagedine has been researched along with Blood Pressure, High in 29 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The involvement of nitric oxide (NO), prostaglandins, and calcium-dependent potassium channel (K(Ca)) activators on the negative modulation of phenylephrine-induced contractions was evaluated on the isolated aorta and caudal (CAU) artery obtained from rats treated with ouabain for 5 wk to induce hypertension." | 7.71 | Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors. ( Alonso, MJ; Barker, LA; Briones, AM; Miguel, M; Rossoni, LV; Salaices, M; Vassallo, DV, 2002) |
| " Obesity was induced by the administration of 4 mg/g body weight of monosodium glutamate (MSG) or equimolar saline (CTR) in newborn rats." | 3.85 | iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats. ( Cecchini, R; da Cunha, NV; Lopes, FN; Martins-Pinge, MC; Panis, C; Pinge-Filho, P, 2017) |
| "The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine." | 3.72 | The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004) |
| "The involvement of nitric oxide (NO), prostaglandins, and calcium-dependent potassium channel (K(Ca)) activators on the negative modulation of phenylephrine-induced contractions was evaluated on the isolated aorta and caudal (CAU) artery obtained from rats treated with ouabain for 5 wk to induce hypertension." | 3.71 | Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors. ( Alonso, MJ; Barker, LA; Briones, AM; Miguel, M; Rossoni, LV; Salaices, M; Vassallo, DV, 2002) |
| "Reduced vascular histamine content is postulated to contribute to increased peripheral vascular resistance in experimental hypertension in rats." | 3.67 | Studies on uptake and catabolism of vascular histamine in spontaneously hypertensive rats. ( Holcslaw, TL; Nichols, G; Wilson, C, 1985) |
| " Chronic administration of AG did not modify significantly any parameter in cirrhotic and control animals." | 1.31 | [Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites]. ( Atucha, NM; Eleno, N; Fortepiani, LA; García-Estañ, J; López-Novoa, JM; Martínez-Salgado, C; Ortiz, MC, 2001) |
| "Arterial hypertension has been identified as a major secondary risk factor for diabetic retinopathy." | 1.29 | Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat. ( Brownlee, M; Edelstein, D; Federlin, K; Hammes, HP; Martin, S; Saleck, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 16 (55.17) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Zicha, J | 2 |
| Řezáčová, L | 1 |
| Vaněčková, I | 1 |
| da Cunha, NV | 1 |
| Lopes, FN | 1 |
| Panis, C | 1 |
| Cecchini, R | 1 |
| Pinge-Filho, P | 1 |
| Martins-Pinge, MC | 1 |
| Kimura, Y | 1 |
| Hirooka, Y | 1 |
| Kishi, T | 1 |
| Ito, K | 1 |
| Sagara, Y | 1 |
| Sunagawa, K | 1 |
| Carnevale, D | 1 |
| Mascio, G | 1 |
| D'Andrea, I | 1 |
| Fardella, V | 1 |
| Bell, RD | 1 |
| Branchi, I | 1 |
| Pallante, F | 1 |
| Zlokovic, B | 1 |
| Yan, SS | 1 |
| Lembo, G | 1 |
| Mukohda, M | 1 |
| Okada, M | 1 |
| Hara, Y | 1 |
| Yamawaki, H | 1 |
| Huang, CF | 1 |
| Hsu, CN | 1 |
| Chien, SJ | 1 |
| Lin, YJ | 1 |
| Huang, LT | 1 |
| Tain, YL | 1 |
| Sharma, B | 1 |
| Singh, N | 1 |
| Rossoni, LV | 1 |
| Salaices, M | 1 |
| Miguel, M | 1 |
| Briones, AM | 1 |
| Barker, LA | 1 |
| Vassallo, DV | 1 |
| Alonso, MJ | 1 |
| Tian, N | 1 |
| Gannon, AW | 1 |
| Khalil, RA | 1 |
| Manning, RD | 2 |
| Kobayashi, N | 1 |
| Horinaka, S | 1 |
| Mita, S | 1 |
| Yoshida, K | 1 |
| Honda, T | 1 |
| Kobayashi, T | 1 |
| Hara, K | 1 |
| Nishikimi, T | 1 |
| Matsuoka, H | 1 |
| Pechánová, O | 1 |
| Dobesová, Z | 1 |
| Cejka, J | 1 |
| Kunes, J | 1 |
| Cheng, PY | 1 |
| Chen, JJ | 1 |
| Yen, MH | 3 |
| Sun, Y | 1 |
| Iemitsu, M | 1 |
| Shimojo, N | 2 |
| Miyauchi, T | 1 |
| Amamiya, M | 1 |
| Sumi, D | 1 |
| Hayashi, T | 1 |
| Sun, G | 1 |
| Kumagai, Y | 1 |
| Neves, SR | 1 |
| Machado, CR | 1 |
| Pinto, AM | 1 |
| Borges, AH | 1 |
| Cunha, FQ | 1 |
| Camargos, ER | 1 |
| McEniery, CM | 1 |
| Chan, V | 1 |
| Hoey, A | 1 |
| Brown, L | 1 |
| Wang, X | 1 |
| Chang, T | 1 |
| Jiang, B | 1 |
| Desai, K | 1 |
| Wu, L | 1 |
| Castellino, P | 1 |
| Tuttle, KR | 1 |
| DeFronzo, RA | 1 |
| Hammes, HP | 1 |
| Brownlee, M | 2 |
| Edelstein, D | 2 |
| Saleck, M | 1 |
| Martin, S | 1 |
| Federlin, K | 1 |
| Wolffenbuttel, BH | 1 |
| van Haeften, TW | 1 |
| Tsukahara, H | 1 |
| Imura, T | 1 |
| Tsuchida, S | 1 |
| Nunose, M | 1 |
| Hori, C | 1 |
| Hiraoka, M | 1 |
| Gejyo, F | 1 |
| Sudo, M | 1 |
| Liu, YC | 1 |
| Hong, HJ | 2 |
| Sheu, JR | 1 |
| Wu, CC | 1 |
| Arai, T | 1 |
| Morimoto, K | 1 |
| Oka, M | 1 |
| Hikita, T | 1 |
| Arai, K | 1 |
| Umezawa, K | 1 |
| Nagase, M | 1 |
| Yamamoto, T | 1 |
| Loh, SH | 1 |
| Tan, DY | 1 |
| Meng, S | 1 |
| Cason, GW | 1 |
| Zhu, Y | 1 |
| Bian, Z | 1 |
| Lu, P | 1 |
| Karas, RH | 1 |
| Bao, L | 1 |
| Cox, D | 1 |
| Hodgin, J | 1 |
| Shaul, PW | 1 |
| Thoren, P | 1 |
| Smithies, O | 1 |
| Gustafsson, JA | 1 |
| Mendelsohn, ME | 1 |
| Ortiz, MC | 1 |
| Fortepiani, LA | 1 |
| Martínez-Salgado, C | 1 |
| Eleno, N | 1 |
| Atucha, NM | 1 |
| López-Novoa, JM | 1 |
| García-Estañ, J | 1 |
| Holcslaw, TL | 1 |
| Nichols, G | 1 |
| Wilson, C | 1 |
1 review available for pimagedine and Blood Pressure, High
| Article | Year |
|---|---|
Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM).
Topics: Acarbose; Aldehyde Reductase; Biguanides; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hy | 1995 |
28 other studies available for pimagedine and Blood Pressure, High
| Article | Year |
|---|---|
Nitric oxide and salt resistance in Dahl rats: no role of inducible NO synthase.
Topics: Animals; Blood Pressure; Hypertension; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Ty | 2023 |
iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats.
Topics: Animals; Arterial Pressure; Autonomic Nervous System; Dinoprostone; Enzyme Inhibitors; Guanidines; H | 2017 |
Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Heart | 2009 |
Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Alzheimer Disease; Amyloid beta-Peptides; An | 2012 |
Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats.
Topics: Acetylcholine; Angiotensin II; Animals; Endothelium, Vascular; Glycation End Products, Advanced; Gua | 2012 |
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Citrulline; Guanidines; Hypertension; Indazoles; | 2013 |
Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats.
Topics: Acetophenones; Animals; Brain Chemistry; Convalescence; Dementia, Vascular; Guanidines; Hypertension | 2013 |
Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors.
Topics: Animals; Biological Factors; Blood Pressure; Cardiotonic Agents; Cyclooxygenase Inhibitors; Endothel | 2002 |
Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Enzyme Induction; Glomerular Filtration Rate; Guanidines; Heart Rate | 2003 |
Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Gene Expression; Guanidines; Heart; Heart Failure; Hyper | 2002 |
Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inh | 2004 |
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blotting, Western; Disease Mode | 2004 |
2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats.
Topics: Animals; Blood Pressure; Cell Membrane; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Guani | 2005 |
Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Heart; Hemodynamics; Hypertension | 2006 |
Novel therapeutic strategies for reducing arterial stiffness.
Topics: Arteries; Cardiovascular Agents; Cardiovascular Diseases; Glycation End Products, Advanced; Guanidin | 2006 |
Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.
Topics: Action Potentials; Animals; Aorta, Thoracic; Cardiovascular Diseases; Collagen; Cross-Linking Reagen | 2006 |
Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal.
Topics: Animals; Aorta; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Free Radicals; Glutathione | 2007 |
Diabetic nephropathy.
Topics: Adrenergic beta-Antagonists; Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1994 |
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat.
Topics: Aneurysm; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1994 |
Renal functional measurements in young rats with chronic inhibition of nitric oxide synthase.
Topics: Animals; Cholesterol; Creatinine; Enzyme Inhibitors; Guanidines; Hypertension; Kidney; Male; NG-Nitr | 1996 |
Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherich | 1997 |
Aminoguanidine induces haematuria of non-glomerular origin in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Arterioles; Blood Pressure; Creatinine; Glomerulonephritis; Guanidines; Hematu | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; | 2000 |
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase.
Topics: Animals; Blood Pressure; Diuresis; Glomerular Filtration Rate; Guanidines; Hemodynamics; Hypertensio | 2000 |
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Blood Pressure; Cells, Cultured; Estradiol; Estrogen Anta | 2002 |
[Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites].
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Guanid | 2001 |
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats.
Topics: Albuminuria; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; | 1992 |
Studies on uptake and catabolism of vascular histamine in spontaneously hypertensive rats.
Topics: Animals; Blood Vessels; Guanidines; Histamine; Hypertension; Imidazoles; In Vitro Techniques; Male; | 1985 |