pimagedine has been researched along with Autoimmune Diabetes in 19 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine is one of the strongest analgesics and is commonly used for the treatment of chronic pain." | 3.77 | Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model. ( Fujita-Hamabe, W; Kishioka, S; Nawa, A; Tokuyama, S, 2011) |
| " A 24-hr pharmacokinetic analysis showed that AG was readily absorbed after i." | 1.29 | Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice. ( Atkinson, MA; Bowman, MA; Cornelius, J; Look, Z; Luchetta, R; Maclaren, NK; Peck, AB; Simell, OG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (57.89) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Arif, B | 1 |
| Arif, Z | 1 |
| Ahmad, J | 1 |
| Perveen, K | 1 |
| Bukhari, NA | 1 |
| Ashraf, JM | 1 |
| Alam, K | 1 |
| Ingaramo, PI | 1 |
| Ronco, MT | 1 |
| Francés, DE | 1 |
| Monti, JA | 1 |
| Pisani, GB | 1 |
| Ceballos, MP | 1 |
| Galleano, M | 1 |
| Carrillo, MC | 1 |
| Carnovale, CE | 1 |
| Nawa, A | 1 |
| Fujita-Hamabe, W | 1 |
| Kishioka, S | 1 |
| Tokuyama, S | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Beder, I | 1 |
| Kittova, M | 1 |
| Mataseje, A | 1 |
| Carsky, J | 2 |
| Orszaghova, Z | 1 |
| Babinska, K | 1 |
| Stoppa, GR | 1 |
| Cesquini, M | 1 |
| Roman, EA | 1 |
| Ogo, SH | 1 |
| Torsoni, MA | 1 |
| Brooks, BA | 1 |
| Heffernan, S | 1 |
| Thomson, S | 1 |
| McLennan, SV | 1 |
| Twigg, SM | 1 |
| Yue, DK | 2 |
| Wu, G | 1 |
| Corbett, JA | 1 |
| Mikhael, A | 1 |
| Shimizu, J | 1 |
| Frederick, K | 1 |
| Misko, TP | 1 |
| McDaniel, ML | 1 |
| Kanagawa, O | 1 |
| Unanue, ER | 1 |
| Pieper, GM | 1 |
| Moore-Hilton, G | 1 |
| Roza, AM | 1 |
| Bowman, MA | 1 |
| Simell, OG | 1 |
| Peck, AB | 1 |
| Cornelius, J | 1 |
| Luchetta, R | 1 |
| Look, Z | 1 |
| Maclaren, NK | 1 |
| Atkinson, MA | 1 |
| Hirasawa, K | 1 |
| Jun, HS | 1 |
| Maeda, K | 1 |
| Kawaguchi, Y | 1 |
| Itagaki, S | 1 |
| Mikami, T | 1 |
| Baek, HS | 1 |
| Doi, K | 1 |
| Yoon, JW | 1 |
| Holstad, M | 1 |
| Jansson, L | 2 |
| Sandler, S | 2 |
| Takamura, T | 1 |
| Kato, I | 1 |
| Kimura, N | 1 |
| Nakazawa, T | 1 |
| Yonekura, H | 1 |
| Takasawa, S | 1 |
| Okamoto, H | 1 |
| Carlsson, PO | 1 |
| Hao, W | 1 |
| Myhre, AP | 1 |
| Palmer, JP | 1 |
| Jakus, V | 1 |
| Hrnciarová, M | 1 |
| Krahulec, B | 1 |
| Rietbrock, N | 1 |
| Birrell, AM | 1 |
| Heffernan, SJ | 1 |
| Ansselin, AD | 1 |
| McLennan, S | 1 |
| Church, DK | 1 |
| Gillin, AG | 1 |
| Makita, Z | 1 |
| Vlassara, H | 1 |
| Rayfield, E | 1 |
| Cartwright, K | 1 |
| Friedman, E | 1 |
| Rodby, R | 1 |
| Cerami, A | 1 |
| Bucala, R | 1 |
2 reviews available for pimagedine and Autoimmune Diabetes
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Guanidines; Humans; Islets of Langerhans; Nit | 1997 |
2 trials available for pimagedine and Autoimmune Diabetes
| Article | Year |
|---|---|
The effect of selected membrane active substances on erythrocyte deformability.
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocyte Membrane; Gua | 2003 |
Inhibition of nonenzymatic protein glycation and lipid peroxidation by drugs with antioxidant activity.
Topics: Aged; Antioxidants; Captopril; Depression, Chemical; Diabetes Mellitus, Type 1; Erythrocytes; Glycos | 1999 |
15 other studies available for pimagedine and Autoimmune Diabetes
| Article | Year |
|---|---|
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress.
Topics: Alloxan; Animals; Antioxidants; Case-Control Studies; Catalase; Diabetes Mellitus, Experimental; Dia | 2022 |
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Diabetes Mellitus, | 2011 |
Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model.
Topics: Administration, Oral; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2011 |
Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors | 2006 |
The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothe | 2008 |
Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Diabetes Mellitus, Type 1; Guanidines; Male; N | 1995 |
Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.
Topics: Amino Acid Oxidoreductases; Animals; Diabetes Mellitus, Type 1; Female; Guanidines; Immunotherapy, A | 1993 |
Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Type 1; Endothelium, Vascular; | 1996 |
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Female; Guanidines; Islets of Langerhans; Mic | 1996 |
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.
Topics: Animals; Cardiovirus Infections; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Encepha | 1997 |
Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA Damage; Guanidines; Insulin | 1998 |
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase.
Topics: Aging; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Colon; Diabetes Mellitus, Type 1 | 1998 |
Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylase.
Topics: Animals; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Guanidines; HSP70 Heat-Shock Proteins; | 1999 |
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function.
Topics: Aging; Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2000 |
Hemoglobin-AGE: a circulating marker of advanced glycosylation.
Topics: Adult; Aging; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immuno | 1992 |