pimagedine and Asthma
pimagedine has been researched along with Asthma in 9 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses." | 7.79 | Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013) |
| " The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses." | 3.79 | Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013) |
| "The role of the L-arginine-nitric oxide (NO) pathway in bronchial asthma that is characterized by eosinophilic airway inflammation has not yet been established." | 3.70 | Manipulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice. ( Ichinose, T; Lim, HB; Miyabara, Y; Sagai, M; Takano, H; Yoshikawa, T, 1999) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Calixto, MC | 1 |
| Lintomen, L | 1 |
| André, DM | 1 |
| Leiria, LO | 1 |
| Ferreira, D | 1 |
| Lellis-Santos, C | 1 |
| Anhê, GF | 1 |
| Bordin, S | 1 |
| Landgraf, RG | 2 |
| Antunes, E | 1 |
| Ishiura, Y | 1 |
| Fujimura, M | 1 |
| Nobata, K | 1 |
| Oribe, Y | 1 |
| Abo, M | 1 |
| Myou, S | 1 |
| Nonomura, A | 1 |
| Russo, M | 1 |
| Jancar, S | 1 |
| Abe, M | 1 |
| Hayashi, Y | 1 |
| Murai, A | 1 |
| Shibata, K | 1 |
| Sakata, N | 1 |
| Igarashi, R | 1 |
| Katsuragi, T | 1 |
| Tanaka, K | 1 |
| Brindicci, C | 1 |
| Ito, K | 1 |
| Barnes, PJ | 2 |
| Kharitonov, SA | 2 |
| Yates, DH | 1 |
| Thomas, PS | 1 |
| Tamaoki, J | 1 |
| Nakata, J | 1 |
| Takeyama, K | 1 |
| Chiyotani, A | 1 |
| Konno, K | 1 |
| Schuiling, M | 1 |
| Meurs, H | 1 |
| Zuidhof, AB | 1 |
| Venema, N | 1 |
| Zaagsma, J | 1 |
| Takano, H | 1 |
| Lim, HB | 1 |
| Miyabara, Y | 1 |
| Ichinose, T | 1 |
| Yoshikawa, T | 1 |
| Sagai, M | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind, Crossover Placebo-controlled Study to Evaluate the Effect of L-arginine and Aminoguanidine on Bronchial, Alveolar and Nasal NO and NO Metabolites[NCT00159380] | 16 participants (Actual) | Interventional | 2003-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
2 trials available for pimagedine and Asthma
| Article | Year |
|---|---|
Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers.
Topics: Administration, Inhalation; Adult; Air; Asthma; Double-Blind Method; Enzyme Inhibitors; Exhalation; | 2007 |
Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase.
Topics: Administration, Inhalation; Adult; Arginine; Asthma; Double-Blind Method; Female; Forced Expiratory | 1996 |
Other Studies
7 other studies available for pimagedine and Asthma
| Article | Year |
|---|---|
Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.
Topics: AMP-Activated Protein Kinases; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Die | 2013 |
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lav | 2005 |
Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Asthma; Bronchoalveolar Lavage Fluid; Bronchocon | 2005 |
Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule.
Topics: Amidines; Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Down-Regulation; Drug Synergism; | 2006 |
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship | 1997 |
Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs.
Topics: Acute Disease; Adjuvants, Immunologic; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronch | 1998 |
Manipulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice.
Topics: Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Enzyme Inhibitors; Eosinophi | 1999 |