Page last updated: 2024-10-22

pimagedine and Asthma

pimagedine has been researched along with Asthma in 9 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
" The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses."7.79Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013)
" The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses."3.79Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013)
"The role of the L-arginine-nitric oxide (NO) pathway in bronchial asthma that is characterized by eosinophilic airway inflammation has not yet been established."3.70Manipulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice. ( Ichinose, T; Lim, HB; Miyabara, Y; Sagai, M; Takano, H; Yoshikawa, T, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (44.44)18.2507
2000's4 (44.44)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calixto, MC1
Lintomen, L1
André, DM1
Leiria, LO1
Ferreira, D1
Lellis-Santos, C1
Anhê, GF1
Bordin, S1
Landgraf, RG2
Antunes, E1
Ishiura, Y1
Fujimura, M1
Nobata, K1
Oribe, Y1
Abo, M1
Myou, S1
Nonomura, A1
Russo, M1
Jancar, S1
Abe, M1
Hayashi, Y1
Murai, A1
Shibata, K1
Sakata, N1
Igarashi, R1
Katsuragi, T1
Tanaka, K1
Brindicci, C1
Ito, K1
Barnes, PJ2
Kharitonov, SA2
Yates, DH1
Thomas, PS1
Tamaoki, J1
Nakata, J1
Takeyama, K1
Chiyotani, A1
Konno, K1
Schuiling, M1
Meurs, H1
Zuidhof, AB1
Venema, N1
Zaagsma, J1
Takano, H1
Lim, HB1
Miyabara, Y1
Ichinose, T1
Yoshikawa, T1
Sagai, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double Blind, Crossover Placebo-controlled Study to Evaluate the Effect of L-arginine and Aminoguanidine on Bronchial, Alveolar and Nasal NO and NO Metabolites[NCT00159380]16 participants (Actual)Interventional2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for pimagedine and Asthma

ArticleYear
Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers.
    Chest, 2007, Volume: 132, Issue:2

    Topics: Administration, Inhalation; Adult; Air; Asthma; Double-Blind Method; Enzyme Inhibitors; Exhalation;

2007
Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase.
    American journal of respiratory and critical care medicine, 1996, Volume: 154, Issue:1

    Topics: Administration, Inhalation; Adult; Arginine; Asthma; Double-Blind Method; Female; Forced Expiratory

1996

Other Studies

7 other studies available for pimagedine and Asthma

ArticleYear
Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Die

2013
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
    Prostaglandins & other lipid mediators, 2005, Volume: 75, Issue:1-4

    Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lav

2005
Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses.
    European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3

    Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Asthma; Bronchoalveolar Lavage Fluid; Bronchocon

2005
Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule.
    Free radical biology & medicine, 2006, Mar-15, Volume: 40, Issue:6

    Topics: Amidines; Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Down-Regulation; Drug Synergism;

2006
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
    The Journal of allergy and clinical immunology, 1997, Volume: 99, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship

1997
Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:5 Pt 1

    Topics: Acute Disease; Adjuvants, Immunologic; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronch

1998
Manipulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice.
    Toxicology, 1999, Nov-29, Volume: 139, Issue:1-2

    Topics: Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Enzyme Inhibitors; Eosinophi

1999