pimagedine has been researched along with Arteriosclerosis in 21 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 7.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 3.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "AGEs accumulate in renal failure as a result of decreased excretion and increased generation resulting from oxidative and carbonyl stress of uremia." | 2.41 | Advanced glycation end products: a Nephrologist's perspective. ( Choudhury, D; Levi, M; Raj, DS; Welbourne, TC, 2000) |
| "Hyperglycemia is considered a key causal factor in the development of diabetic vascular complications and can mediate its adverse effects through multiple pathways." | 2.41 | Glycation as the glucose link to diabetic complications. ( Gugliucci, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, PH | 2 |
| Wang, M | 1 |
| Deng, YL | 2 |
| Fan, H | 1 |
| Shira-Bock, L | 1 |
| Kawakami, M | 1 |
| Kuroki, M | 1 |
| Jakus, V | 1 |
| Rietbrock, N | 1 |
| Forbes, JM | 1 |
| Yee, LT | 1 |
| Thallas, V | 1 |
| Lassila, M | 1 |
| Candido, R | 1 |
| Jandeleit-Dahm, KA | 1 |
| Thomas, MC | 1 |
| Burns, WC | 1 |
| Deemer, EK | 1 |
| Thorpe, SR | 2 |
| Thorpe, SM | 1 |
| Cooper, ME | 2 |
| Allen, TJ | 1 |
| Zhong, W | 1 |
| Wang, LL | 1 |
| Cui, H | 1 |
| Li, S | 1 |
| Sobey, CG | 1 |
| Brooks, RM | 1 |
| Heistad, DD | 1 |
| Friedman, EA | 1 |
| Vlassara, H | 2 |
| Bucala, R | 2 |
| Schleicher, ED | 1 |
| Wagner, E | 1 |
| Nerlich, AG | 1 |
| Che, W | 1 |
| Asahi, M | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Okado, A | 1 |
| Higashiyama, S | 1 |
| Taniguchi, N | 2 |
| Panagiotopoulos, S | 1 |
| O'Brien, RC | 1 |
| Jerums, G | 1 |
| Ohta, M | 1 |
| Raj, DS | 1 |
| Choudhury, D | 1 |
| Welbourne, TC | 1 |
| Levi, M | 1 |
| Imanaga, Y | 1 |
| Sakata, N | 2 |
| Takebayashi, S | 2 |
| Matsunaga, A | 1 |
| Sasaki, J | 1 |
| Arakawa, K | 1 |
| Nagai, R | 2 |
| Horiuchi, S | 2 |
| Itabe, H | 2 |
| Takano, T | 2 |
| Baynes, JW | 1 |
| Gugliucci, A | 1 |
| Uesugi, N | 1 |
| Jono, T | 1 |
| Takeya, M | 1 |
| Myint, T | 1 |
| Requena, JR | 1 |
| Vidal, P | 1 |
| Cabezas-Cerrato, J | 1 |
11 reviews available for pimagedine and Arteriosclerosis
| Article | Year |
|---|---|
[Aminoguanidine and other AGE inhibitors].
Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diab | 2002 |
Advanced glycation end-products and the progress of diabetic vascular complications.
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glyco | 2004 |
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes].
Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Product | 2005 |
Will pimagidine improve survival of diabetics on dialysis?
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Guani | 1996 |
Advanced glycation end-products and atherosclerosis.
Topics: Animals; Arteriosclerosis; Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Glycation En | 1996 |
What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?
Topics: Animals; Arteriosclerosis; Glycation End Products, Advanced; Glycosylation; Guanidines; Humans; Hype | 1996 |
[Current advances in the treatment of diabetes mellitus].
Topics: Aldehyde Reductase; Arteriosclerosis; Blood Glucose; Diabetes Mellitus; Enzyme Inhibitors; Guanidine | 1999 |
Advanced glycation end products: a Nephrologist's perspective.
Topics: Aging; Arteriosclerosis; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Adv | 2000 |
Glycoxidation and lipoxidation in atherogenesis.
Topics: Aldehydes; Animals; Antioxidants; Arteriosclerosis; Carbohydrate Metabolism; Endothelium, Vascular; | 2000 |
Glycation as the glucose link to diabetic complications.
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycated Hemoglo | 2000 |
Intervening in atherogenesis: lessons from diabetes.
Topics: Arteriosclerosis; Cooking; Diabetes Mellitus; Diet, Atherogenic; Enzyme Inhibitors; Glucose; Glycati | 2000 |
10 other studies available for pimagedine and Arteriosclerosis
| Article | Year |
|---|---|
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
Topics: Albuminuria; Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Arteriosclerosis; | 2002 |
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.
Topics: Actins; Animals; Aorta; Arteriosclerosis; Collagen; Cytokines; Diabetes Mellitus, Experimental; Diab | 2004 |
Evidence that expression of inducible nitric oxide synthase in response to endotoxin is augmented in atherosclerotic rabbits.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arteriosclerosis; Blood Pressure; Enzyme Induction; Fema | 1995 |
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch | 1997 |
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Cell Nucleus; Cells, Cultured; Cyclohexi | 1997 |
Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit.
Topics: Animals; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Enzyme Inhibitors; Glycation End Produ | 1998 |
Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover.
Topics: Allyl Compounds; Amine Oxidase (Copper-Containing); Animals; Aorta; Arteriosclerosis; Butylamines; C | 1998 |
In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Aortic Diseases; Arteriosclerosis; Chelating Agents | 2000 |
Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Chelating Agents; Copper; Edetic Acid; Enzyme Inhi | 2001 |
Aminoguanidine inhibits the modification of proteins by lipid peroxidation derived aldehydes: a possible antiatherogenic agent.
Topics: Aldehydes; Apolipoproteins B; Arteriosclerosis; Electrophoresis, Agar Gel; Guanidines; Humans; Lipid | 1992 |