pimagedine has been researched along with Alloxan Diabetes in 216 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 7.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| "We examined the ability of a pyridoxal-aminoguanidine adduct with both antiglycation and antioxidant activities in vitro to protect against neuropathy and cataract in streptozotocin-diabetic rats and compared the result with that of aminoguanidine." | 7.72 | Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats. ( Chen, AS; Kamei, A; Miwa, I; Sugiura, M; Taguchi, T; Wakasugi, Y; Wang, MW, 2004) |
| "This study examined whether the prevention of diabetes-related albuminuria by aminoguanidine (AG) or ramipril (RAM) may be mediated by a common post-glomerular basement membrane renal intracellular mechanism involving protein kinase C (PKC)." | 7.70 | Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. ( Clavant, SP; Comper, WD; Jerums, G; Kemp, BE; Kiriazis, Z; Osicka, TM; Panagiotopoulos, S; Pike, RN; Pratt, LM; Russo, LM; Yu, Y, 2000) |
| "Morphine is one of the strongest analgesics and is commonly used for the treatment of chronic pain." | 3.77 | Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model. ( Fujita-Hamabe, W; Kishioka, S; Nawa, A; Tokuyama, S, 2011) |
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 3.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| " Both aminoguanidine and perindopril retarded the increase in albuminuria, which was completely abrogated by combination therapy." | 3.72 | Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. ( Allen, TJ; Burns, WC; Cooper, ME; Davis, BJ; Forbes, JM; Jerums, G; Kawachi, H; Thomas, MC, 2004) |
| "We examined the ability of a pyridoxal-aminoguanidine adduct with both antiglycation and antioxidant activities in vitro to protect against neuropathy and cataract in streptozotocin-diabetic rats and compared the result with that of aminoguanidine." | 3.72 | Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats. ( Chen, AS; Kamei, A; Miwa, I; Sugiura, M; Taguchi, T; Wakasugi, Y; Wang, MW, 2004) |
| "A nonselective inhibitor of cyclooxygenase (COX; high-dose aspirin) and a relatively selective inhibitor of inducible nitric oxide synthase (iNOS; aminoguanidine) have been found to inhibit development of diabetic retinopathy in animals, raising a possibility that NOS and COX play important roles in the development of retinopathy." | 3.72 | Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. ( Du, Y; Kern, TS; Sarthy, VP, 2004) |
| "This study examined whether the prevention of diabetes-related albuminuria by aminoguanidine (AG) or ramipril (RAM) may be mediated by a common post-glomerular basement membrane renal intracellular mechanism involving protein kinase C (PKC)." | 3.70 | Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. ( Clavant, SP; Comper, WD; Jerums, G; Kemp, BE; Kiriazis, Z; Osicka, TM; Panagiotopoulos, S; Pike, RN; Pratt, LM; Russo, LM; Yu, Y, 2000) |
| "Cataract formation occurred after 13 weeks in diabetic animals compared with 17 weeks for those treated with aminoguanidine, and 16 weeks for those treated with probucol (p < 0." | 3.70 | Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. ( Agardh, C; Agardh, E; Hultberg, B, 2000) |
| "To examine the relationship between early retinal capillary cell apoptosis and late histologic lesions of diabetic retinopathy and to compare the effects of aminoguanidine (AMG) on the retinopathies caused by diabetes and galactose feeding." | 3.70 | Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. ( Kern, TS; Kowluru, RA; Lorenzi, M; Mizutani, M; Nagaraj, RH; Podesta, F; Romeo, G; Tang, J, 2000) |
| " Using NG-nitro-L-arginine methyl ester, an inhibitor of both the constitutive and the cytokine inducible forms of nitric oxide synthase, and aminoguanidine, a preferential inhibitor of the inducible form of nitric oxide synthase, we investigated the impact of inhibiting nitric oxide production on food-intake, body weight and temperature, blood glucose, plasma insulin, glucagon, corticosterone and leukocyte- and differential-counts in normal rats injected once daily for 5 days with interleukin 1 beta (IL-1 beta) (0." | 3.69 | Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases. ( Bjerre, U; Mandrup-Poulsen, T; Nerup, J; Reimers, JI, 1994) |
| " Herein, we examined the analgesic effects of orally administered morphine and its pharmacokinetic properties under diabetic conditions, specifically focusing on the involvement of intestinal P-gp in a type 1 diabetic mouse model." | 2.48 | [Altered intestinal P-glycoprotein expression levels affect pharmacodynamics under diabetic condition]. ( Fujita-Hamabe, W; Kisioka, S; Nawa, A; Tokuyama, S, 2012) |
| "Pyridoxamine is a post-Amadori AGE inhibitor-that is, an "Amadorin"-whereas aminoguanidine primarily scavenges reactive dicarbonyl precursors to AGEs." | 2.43 | Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design. ( Chen, Y; Khalifah, RG; Wassenberg, JJ, 2005) |
| "Background Although diabetes attenuates abdominal aortic aneurysms (AAAs), the mechanisms by which diabetes suppresses AAAs remain incompletely understood." | 1.91 | Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice. ( Chen, X; Dalman, RL; Ge, Y; Guo, J; Ikezoe, T; Li, G; Li, Y; Miyata, M; Samura, M; Shoji, T; Xu, B; Zhao, S; Zheng, X, 2023) |
| "In rats with untreated diabetes, hyperglycaemia, increased activity of inducible nitric oxide (NO) synthase, increased NO, mild vascular spasm, reduced NO bioavailability and diminished vasorelaxation were found." | 1.36 | NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. ( Dai, DZ; Dai, Y; Zheng, YF, 2010) |
| "Functional hyperemia is believed to be mediated by glial cells and we found that glial-evoked vasodilation was reduced by 60% in diabetic animals." | 1.36 | Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy. ( Mishra, A; Newman, EA, 2010) |
| "Intimal hyperplasia is one of the major pathological processes in vein graft failure with diabetes mellitus." | 1.35 | The role of RAGE in aminoguanidine-induced suppression of venous intimal hyperplasia in diabetic rats. ( Diao, Y; Huo, X; Wang, X; Zhang, H; Zhang, Q, 2009) |
| "After induction of type 2 diabetes, rats received daily injections of AG (50 mg kg(-1), i." | 1.35 | Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. ( Chang, KC; Liang, JT; Lin, YD; Tseng, YZ; Wu, ET; Wu, MS, 2008) |
| " Vasorelaxation to acetylcholine (ACh) and functional assessment of nitric oxide (NO) bioavailability was determined in the thoracic aorta." | 1.34 | Upregulated endothelin system in diabetic vascular dysfunction and early retinopathy is reversed by CPU0213 and total triterpene acids from Fructus Corni. ( Dai, DZ; Dai, Y; Liu, HR; Na, T; Su, W, 2007) |
| "Humans with type 2 diabetes and nephropathy displayed similar alterations in MMP-7 to their rodent counterparts." | 1.34 | Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? ( Dy, V; Gilbert, RE; Kelly, DJ; Langham, RG; McLennan, SV; Schache, M; Waltham, M; Yue, DK, 2007) |
| "The NIDDM was induced in male Wistar rats, which were administered intraperitoneally with 180 mg kg(-1) nicotinamide (NA) 30 min before an intravenous injection of 50 mg kg(-1) streptozotocin (STZ)." | 1.33 | Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes. ( Chang, KC; Cho, YL; Liang, JT; Tsai, MS; Tseng, CD; Tseng, YZ; Wu, MS, 2006) |
| "The degree of contraction of the open wounds was evaluated for 2 weeks duration." | 1.33 | Collagen ultrastructure and TGF-beta1 expression preserved with aminoguanidine during wound healing in diabetic rats. ( Akalin, S; Burçak, G; Cetinel, S; Civelek, S; Deyneli, O; Haklar, G; Kaya, H; San, T; Tuğtepe, H; Uyar, S; Yavuz, D, 2005) |
| " We conclude that long-term administration of AG to the STZ-treated rats imparts significant protection against the diabetes-derived deterioration in vascular dynamics, at least partly through inhibition of the AGEs accumulation on collagen in the arterial wall." | 1.33 | Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats. ( Chang, KC; Cho, YL; Hsu, KL; Lin, YD; Tseng, CD; Tseng, YZ, 2006) |
| "Perindopril treatment produced improvements (p<0." | 1.32 | ACE inhibition salvages the visual loss caused by diabetes. ( Armitage, JA; Bui, BV; Cooper, ME; Tolcos, M; Vingrys, AJ, 2003) |
| "After 8 weeks of treatment, hindlimb ischemia was induced by right femoral artery ligature." | 1.32 | Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice. ( Benessiano, J; Duriez, M; Ebrahimian, TG; Huijberts, M; Lévy, BI; Silvestre, JS; Tamarat, R; Wautier, JL; Wautier, MP, 2003) |
| "The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent." | 1.31 | ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. ( Cooper, ME; Davis, B; Jaworski, K; Kelly, DJ; Koerner, SM; Thallas, V; Wilkinson-Berka, JL, 2002) |
| "Two months of diabetes or experimental galactosemia in rats resulted in elevation of retinal oxidative stress (increase in thiobarbituric acid reactive substances, TBARS, and decrease in glutathione, GSH), NO, and PKC activity." | 1.31 | Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine. ( Engerman, RL; Kern, TS; Kowluru, RA, 2000) |
| "Cataract was observed in all six of the surviving rats in Groups 2 and 4, and in one of 6 surviving rats in group 3." | 1.31 | Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats. ( Azal, O; Baydar, A; Cakir, B; Corakçi, A; Güler, S; Kutlu, M; Yönem, A, 2002) |
| "Malondialdehyde (MDA) content was significantly elevated and activities of SOD and catalase decreased in the kidneys of STZ-diabetic rats." | 1.30 | Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney. ( Kedziora-Kornatowska, K; Luciak, M, 1998) |
| "We have previously shown that long-term administration of aminoguanidine, an inhibitor of advanced glycosylation product formation, reduces the extent of experimental diabetic retinopathy in the rat by 85%." | 1.29 | Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats. ( Ali, SS; Brownlee, M; Federlin, K; Geisen, K; Hammes, HP; Uhlmann, M; Weiss, A, 1995) |
| "Arterial hypertension has been identified as a major secondary risk factor for diabetic retinopathy." | 1.29 | Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat. ( Brownlee, M; Edelstein, D; Federlin, K; Hammes, HP; Martin, S; Saleck, M, 1994) |
| "Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR." | 1.29 | Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993) |
| "Myo-inositol levels were 18% decreased by diabetes." | 1.28 | Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats. ( Cameron, NE; Cotter, MA; Dines, K; Love, A, 1992) |
| "Diaminoguanidine was a stronger inhibitor than monoaminoguanidine." | 1.28 | Inhibition of diabetes-associated complications by nucleophilic compounds. ( Bansal, V; Kumari, K; Sahib, MK; Umar, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.93) | 18.7374 |
| 1990's | 82 (37.96) | 18.2507 |
| 2000's | 90 (41.67) | 29.6817 |
| 2010's | 37 (17.13) | 24.3611 |
| 2020's | 5 (2.31) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, D | 1 |
| Fan, Y | 1 |
| Xu, X | 2 |
| Takenokuchi, M | 1 |
| Matsumoto, K | 2 |
| Nitta, Y | 1 |
| Takasugi, R | 1 |
| Inoue, Y | 1 |
| Iwai, M | 1 |
| Kadoyama, K | 1 |
| Yoshida, K | 1 |
| Takano-Ohmuro, H | 1 |
| Taniguchi, T | 1 |
| Arif, B | 1 |
| Arif, Z | 1 |
| Ahmad, J | 1 |
| Perveen, K | 1 |
| Bukhari, NA | 1 |
| Ashraf, JM | 1 |
| Alam, K | 1 |
| Li, Y | 2 |
| Zheng, X | 1 |
| Guo, J | 1 |
| Samura, M | 1 |
| Ge, Y | 1 |
| Zhao, S | 1 |
| Li, G | 1 |
| Chen, X | 1 |
| Shoji, T | 1 |
| Ikezoe, T | 1 |
| Miyata, M | 1 |
| Xu, B | 1 |
| Dalman, RL | 1 |
| Lima, TFO | 1 |
| Costa, MC | 1 |
| Figueiredo, ID | 1 |
| Inácio, MD | 1 |
| Rodrigues, MR | 2 |
| Assis, RP | 1 |
| Baviera, AM | 1 |
| Brunetti, IL | 1 |
| Ahmad, S | 1 |
| Khan, MS | 1 |
| Alouffi, S | 1 |
| Khan, S | 1 |
| Khan, M | 1 |
| Akashah, R | 1 |
| Faisal, M | 1 |
| Shahab, U | 1 |
| Song, Y | 1 |
| Zhang, F | 2 |
| Ying, C | 1 |
| Kumar, KA | 1 |
| Zhou, X | 1 |
| Pei, Z | 1 |
| Deng, Q | 1 |
| Babcock, SA | 1 |
| He, EY | 1 |
| Ren, J | 1 |
| Zhang, Y | 2 |
| Chang, GJ | 1 |
| Yeh, YH | 1 |
| Chen, WJ | 1 |
| Ko, YS | 1 |
| Pang, JS | 1 |
| Lee, HY | 1 |
| Li, C | 1 |
| Wang, Z | 1 |
| Li, X | 1 |
| Chen, J | 2 |
| Zheng, N | 1 |
| Lin, X | 1 |
| Wen, Q | 1 |
| Zhang, S | 1 |
| Huang, J | 1 |
| Huang, R | 1 |
| Shi, FH | 1 |
| Cheng, YS | 1 |
| Dai, DZ | 4 |
| Peng, HJ | 1 |
| Cong, XD | 2 |
| Dai, Y | 4 |
| Tian, M | 2 |
| Qing, C | 3 |
| Niu, Y | 1 |
| Dong, J | 2 |
| Cao, X | 1 |
| Song, F | 1 |
| Ji, X | 1 |
| Lu, S | 1 |
| Firouzjaei, MA | 1 |
| Jafari, MR | 2 |
| Eskandari, M | 1 |
| Anarkoli, IJ | 1 |
| Alipour, M | 2 |
| Kim, J | 1 |
| Kim, CS | 1 |
| Sohn, E | 1 |
| Lee, YM | 1 |
| Jo, K | 1 |
| Shin, SD | 1 |
| Kim, JS | 1 |
| Elbe, H | 2 |
| Vardı, N | 2 |
| Orman, D | 2 |
| Taşlıdere, E | 2 |
| Yıldız, A | 1 |
| Ates, B | 1 |
| de Souza Ferreira, C | 1 |
| Pennacchi, PC | 1 |
| Araújo, TH | 1 |
| Taniwaki, NN | 1 |
| de Araújo Paula, FB | 1 |
| da Silveira Duarte, SM | 1 |
| Singh, P | 1 |
| Jayaramaiah, RH | 1 |
| Agawane, SB | 1 |
| Vannuruswamy, G | 1 |
| Korwar, AM | 1 |
| Anand, A | 1 |
| Dhaygude, VS | 1 |
| Shaikh, ML | 2 |
| Joshi, RS | 1 |
| Boppana, R | 2 |
| Kulkarni, MJ | 2 |
| Thulasiram, HV | 1 |
| Giri, AP | 2 |
| Bhat, S | 1 |
| Jagadeeshaprasad, MG | 1 |
| Patil, YR | 1 |
| Regin, BS | 1 |
| Mohan, V | 1 |
| Balasubramanyam, M | 1 |
| Adineh, F | 1 |
| Mosatafavi, H | 1 |
| Aminabadi, A | 1 |
| Monirinasab, H | 1 |
| Zhou, XY | 1 |
| Ying, CJ | 1 |
| Chen, L | 1 |
| Shi, Y | 1 |
| Tang, M | 1 |
| Hu, XT | 1 |
| Pan, ZH | 1 |
| Xu, NN | 1 |
| Zheng, KY | 1 |
| Tang, RX | 1 |
| Song, YJ | 1 |
| Gül, M | 1 |
| Emre, S | 1 |
| Eşrefoğlu, M | 1 |
| Vard, N | 1 |
| Yan, H | 1 |
| Guo, Y | 1 |
| Zhang, J | 1 |
| Ding, Z | 1 |
| Ha, W | 1 |
| Harding, JJ | 1 |
| Wang, X | 1 |
| Diao, Y | 1 |
| Zhang, H | 1 |
| Huo, X | 1 |
| Zhang, Q | 1 |
| El Shazly, AH | 1 |
| Mahmoud, AM | 1 |
| Darwish, NS | 1 |
| Wang, SH | 1 |
| Sun, ZL | 1 |
| Guo, YJ | 1 |
| Yuan, Y | 1 |
| Yang, BQ | 1 |
| Duran-Jimenez, B | 1 |
| Dobler, D | 1 |
| Moffatt, S | 1 |
| Rabbani, N | 1 |
| Streuli, CH | 1 |
| Thornalley, PJ | 1 |
| Tomlinson, DR | 3 |
| Gardiner, NJ | 1 |
| Oak, JH | 1 |
| Youn, JY | 1 |
| Cai, H | 1 |
| Shao, CH | 2 |
| Rozanski, GJ | 1 |
| Nagai, R | 2 |
| Stockdale, FE | 1 |
| Patel, KP | 1 |
| Wang, M | 1 |
| Singh, J | 2 |
| Mayhan, WG | 2 |
| Bidasee, KR | 2 |
| Zheng, YF | 1 |
| Campanucci, V | 1 |
| Krishnaswamy, A | 1 |
| Cooper, E | 1 |
| Mishra, A | 1 |
| Newman, EA | 1 |
| Li, Q | 1 |
| Ao, X | 1 |
| Du, Y | 2 |
| Ou, Y | 1 |
| Gong, R | 1 |
| Sun, X | 1 |
| Yang, YX | 1 |
| Wen, G | 1 |
| Brodiak, IV | 2 |
| Hnatush, AR | 1 |
| Sybirna, NO | 2 |
| Hu, C | 1 |
| Zhang, GL | 1 |
| Nawa, A | 3 |
| Fujita-Hamabe, W | 3 |
| Nakamoto, K | 1 |
| Tokuyama, S | 3 |
| Ingaramo, PI | 1 |
| Ronco, MT | 1 |
| Francés, DE | 1 |
| Monti, JA | 1 |
| Pisani, GB | 1 |
| Ceballos, MP | 1 |
| Galleano, M | 1 |
| Carrillo, MC | 1 |
| Carnovale, CE | 1 |
| Cao, XZ | 1 |
| Niu, YW | 1 |
| Lu, SL | 2 |
| Guimarães, RP | 1 |
| de Oliveira, PA | 1 |
| Oliveira, AM | 1 |
| Carvalho, VF | 1 |
| Florim, LT | 1 |
| de O Barreto, E | 1 |
| Torres, RC | 1 |
| Batista, MM | 1 |
| Amendoeira, FC | 1 |
| Cordeiro, RS | 1 |
| Martins, MA | 1 |
| E Silva, PM | 1 |
| Kishioka, S | 1 |
| Labieniec-Watala, M | 1 |
| Siewiera, K | 1 |
| Jozwiak, Z | 1 |
| Kisioka, S | 1 |
| Chougala, MB | 1 |
| Bhaskar, JJ | 1 |
| Rajan, MG | 1 |
| Salimath, PV | 1 |
| Vadla, GP | 1 |
| Vellaichamy, E | 1 |
| Nordquist, L | 1 |
| Liss, P | 1 |
| Fasching, A | 1 |
| Hansell, P | 1 |
| Palm, F | 1 |
| Ozturk, A | 1 |
| Fırat, C | 1 |
| Parlakpınar, H | 1 |
| Bay-Karabulut, A | 1 |
| Kirimlioglu, H | 1 |
| Gurlek, A | 1 |
| Moore, CJ | 1 |
| Kutty, S | 1 |
| El-seweidy, MM | 1 |
| El-Swefy, SE | 1 |
| Ameen, RS | 1 |
| Hashem, RM | 1 |
| Yavuz, DG | 1 |
| Ersöz, HO | 1 |
| Tuncel, M | 1 |
| Sargon, MF | 1 |
| Küçükkaya, B | 1 |
| Ahiskali, R | 1 |
| Akalin, S | 2 |
| Forbes, JM | 7 |
| Cooper, ME | 18 |
| Thallas, V | 6 |
| Burns, WC | 5 |
| Thomas, MC | 4 |
| Brammar, GC | 1 |
| Lee, F | 1 |
| Grant, SL | 1 |
| Burrell, LM | 1 |
| Burrell, LA | 1 |
| Jerums, G | 15 |
| Osicka, TM | 4 |
| Wilkinson-Berka, JL | 1 |
| Kelly, DJ | 5 |
| Koerner, SM | 1 |
| Jaworski, K | 1 |
| Davis, B | 1 |
| Rao, VS | 1 |
| Santos, FA | 1 |
| Silva, RM | 1 |
| Teixiera, MG | 1 |
| Twigg, SM | 2 |
| Cao, Z | 1 |
| MCLennan, SV | 3 |
| Brammar, G | 1 |
| Guo, SS | 1 |
| Tang, DY | 1 |
| Liang, XC | 1 |
| Bui, BV | 1 |
| Armitage, JA | 1 |
| Tolcos, M | 1 |
| Vingrys, AJ | 1 |
| Rodríguez-Mañas, L | 1 |
| Angulo, J | 1 |
| Vallejo, S | 1 |
| Peiró, C | 1 |
| Sánchez-Ferrer, A | 1 |
| Cercas, E | 1 |
| López-Dóriga, P | 1 |
| Sánchez-Ferrer, CF | 1 |
| Tamarat, R | 1 |
| Silvestre, JS | 1 |
| Huijberts, M | 1 |
| Benessiano, J | 1 |
| Ebrahimian, TG | 1 |
| Duriez, M | 1 |
| Wautier, MP | 1 |
| Wautier, JL | 1 |
| Lévy, BI | 2 |
| Usta, MF | 3 |
| Bivalacqua, TJ | 3 |
| Yang, DY | 1 |
| Ramanitharan, A | 1 |
| Sell, DR | 1 |
| Viswanathan, A | 1 |
| Monnier, VM | 3 |
| Hellstrom, WJ | 3 |
| Chen, AS | 2 |
| Taguchi, T | 2 |
| Aoyama, S | 1 |
| Sugiura, M | 2 |
| Haruna, M | 1 |
| Wang, MW | 2 |
| Miwa, I | 2 |
| Davis, BJ | 1 |
| Kawachi, H | 1 |
| Allen, TJ | 2 |
| Miyata, T | 2 |
| Kurokawa, K | 1 |
| Wakasugi, Y | 1 |
| Kamei, A | 1 |
| Tikellis, C | 1 |
| Kantharidis, P | 1 |
| Yee, LT | 1 |
| Lassila, M | 1 |
| Candido, R | 1 |
| Jandeleit-Dahm, KA | 1 |
| Deemer, EK | 1 |
| Thorpe, SR | 3 |
| Thorpe, SM | 1 |
| Biswas, SK | 1 |
| de Faria, JM | 1 |
| de Faria, JB | 1 |
| Koksal, IT | 1 |
| Toptas, B | 1 |
| Surmen, S | 1 |
| Ge, K | 1 |
| Huang, Y | 2 |
| Chen, SQ | 1 |
| Zhang, G | 1 |
| Chen, RH | 1 |
| Sarthy, VP | 1 |
| Kern, TS | 6 |
| Thallas-Bonke, V | 1 |
| Lindschau, C | 1 |
| Rizkalla, B | 1 |
| Bach, LA | 1 |
| Boner, G | 1 |
| Meier, M | 1 |
| Haller, H | 1 |
| Madar, Z | 1 |
| Kalet-Litman, S | 1 |
| Stark, AH | 1 |
| Stadler, K | 1 |
| Jenei, V | 1 |
| Somogyi, A | 1 |
| Jakus, J | 1 |
| Rosca, MG | 1 |
| Mustata, TG | 1 |
| Kinter, MT | 1 |
| Ozdemir, AM | 1 |
| Szweda, LI | 1 |
| Brownlee, M | 11 |
| Weiss, MF | 1 |
| Pennathur, S | 1 |
| Ido, Y | 1 |
| Heller, JI | 1 |
| Byun, J | 1 |
| Danda, R | 1 |
| Pergola, P | 1 |
| Williamson, JR | 3 |
| Heinecke, JW | 1 |
| Kopman, JA | 1 |
| Kim, DM | 1 |
| Rahman, SS | 1 |
| Arandia, JA | 1 |
| Karimbux, NY | 1 |
| Fiorellini, JP | 1 |
| Yamamoto, M | 2 |
| Izuhara, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of ALT-711 in Combination With Fixed-Dose Hydrochlorothiazide Therapy on Systolic Blood Pressure in Hypertensive Patients[NCT00089713] | Phase 2 | 392 participants | Interventional | 2004-03-31 | Terminated | ||
| Systolic and Pulse Pressure Hemodynamic Improvement By Restoring Elasticity: The SILVER Study[NCT00045994] | Phase 2 | 180 participants | Interventional | 2001-08-31 | Completed | ||
| Systolic and Pulse Pressure Hemodynamic Improvement By Restoring Elasticity: The SAPPHIRE Study[NCT00045981] | Phase 2 | 450 participants | Interventional | 2001-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for pimagedine and Alloxan Diabetes
| Article | Year |
|---|---|
[Nitric oxide synthase-mediated alteration of intestinal P-glycoprotein under hyperglycemic stress].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diabetes Mellitus, Experimental; D | 2011 |
[Altered intestinal P-glycoprotein expression levels affect pharmacodynamics under diabetic condition].
Topics: Administration, Ophthalmic; Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily | 2012 |
A detective story for biomedical footprints towards new therapeutic interventions in diabetic nephropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycation End Products, Advanced; G | 2003 |
[Aminoguanidine and impaired wound healing in diabetes].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Guanidines; Humans; Nitric Oxide Syntha | 2004 |
Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Drug Design; Glycation End Product | 2005 |
Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Glycation En | 2005 |
Serum advanced glycosylation end products: a new class of uremic toxins?
Topics: Animals; Blood Proteins; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetic Nephro | 1994 |
Glycation products and the pathogenesis of diabetic complications.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Retino | 1992 |
Nonenzymatic glycosylation of macromolecules. Prospects of pharmacologic modulation.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycosylation; G | 1992 |
207 other studies available for pimagedine and Alloxan Diabetes
| Article | Year |
|---|---|
The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cell | 2012 |
In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract.
Topics: Animals; Arginine; Collagen; Connaraceae; Diabetes Mellitus, Experimental; Glycation End Products, A | 2022 |
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress.
Topics: Alloxan; Animals; Antioxidants; Case-Control Studies; Catalase; Diabetes Mellitus, Experimental; Dia | 2022 |
Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagen; Diabetes Mellitus, Experimental; Di | 2023 |
Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Curcumin; Diabetes Mellitus, Experime | 2020 |
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Ani | 2021 |
Inhibition of NF-κB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia.
Topics: Animals; Brain; Calcium-Binding Proteins; Cytoplasm; Diabetes Mellitus, Experimental; Diabetic Nephr | 2017 |
Inhibition of advanced glycation endproduct (AGE) rescues against streptozotocin-induced diabetic cardiomyopathy: Role of autophagy and ER stress.
Topics: Animals; Autophagy; Calcium; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiog | 2018 |
Inhibition of Advanced Glycation End Products Formation Attenuates Cardiac Electrical and Mechanical Remodeling and Vulnerability to Tachyarrhythmias in Diabetic Rats.
Topics: Action Potentials; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme | 2019 |
Effects of semicarbazide-sensitive amine oxidase inhibitors on morphology of aorta and kidney in diabetic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Aorta; Diabetes Mellitus, Experimental; Enzyme Inhibitor | 2019 |
Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice.
Topics: Administration, Oral; Animals; Antioxidants; Blotting, Western; Cyclohexenes; Diabetes Mellitus, Exp | 2013 |
Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argirein.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Apoptosis; Arginine; Calcium-Binding Proteins; Di | 2013 |
Effect of aminoguanidine intervention on neutrophils in diabetes inflammatory cells wound healing.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Guanidines; | 2013 |
Aminoguanidine changes hippocampal expression of apoptosis-related genes, improves passive avoidance learning and memory in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis Regulatory Proteins; Avoidance Learning; bcl-2-Associated X Protein; bcl-X Protei | 2014 |
Aminoguanidine protects against apoptosis of retinal ganglion cells in Zucker diabetic fatty rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glycation End Products, A | 2014 |
Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression.
Topics: Actins; Animals; Aorta; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Male; Rats; | 2014 |
Aminoguanidine mitigates apoptosis, testicular seminiferous tubules damage, and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase | 2015 |
Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils.
Topics: Animals; Candida albicans; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Glycation End Produ | 2016 |
Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Eugenol; Glyc | 2016 |
Proteomic Insight Reveals Elevated Levels of Albumin in Circulating Immune Complexes in Diabetic Plasma.
Topics: Animals; Blood Proteins; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene | 2016 |
Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gene Expression Regulati | 2016 |
Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway.
Topics: Animals; Brain; Cognition Disorders; Depressive Disorder; Diabetes Complications; Diabetes Mellitus, | 2017 |
Protective effects of melatonin and aminoguanidine on the cornea in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Corneal Diseases; Diabetes | 2008 |
Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.
Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Cornea; Diabetes Mellitus, Experi | 2008 |
The role of RAGE in aminoguanidine-induced suppression of venous intimal hyperplasia in diabetic rats.
Topics: Animals; Aorta, Abdominal; Cell Proliferation; Diabetes Mellitus, Experimental; Down-Regulation; Gly | 2009 |
Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimenta | 2009 |
Diabetes impairs hippocampal function via advanced glycation end product mediated new neuron generation in animals with diabetes-related depression.
Topics: Animals; Antimetabolites; Behavior, Animal; Blood Glucose; Bromodeoxyuridine; Cell Differentiation; | 2009 |
Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.
Topics: Animals; Chromatography, Liquid; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Extracellular M | 2009 |
Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice.
Topics: Animals; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Electron Spin Resonance Spectroscopy | 2009 |
Carbonylation of myosin heavy chains in rat heart during diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Heart Diseases; Heart Ventr | 2010 |
NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats.
Topics: Animals; Aorta, Thoracic; Connexin 43; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopat | 2010 |
Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue.
Topics: Acetylcholine; Adenoviridae; Age Factors; Aldehydes; Animals; Animals, Newborn; Body Temperature; Ce | 2010 |
Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Guanidines; Hyper | 2010 |
Effects of aminoguanidine and vitamin C on collagen type IV in diabetic nephropathy rats.
Topics: Animals; Ascorbic Acid; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; D | 2011 |
[Effect of L-arginine and aminoguanidine on morphological characteristics of the lymphocyte plasma membranes during experimental diabetes mellitus].
Topics: Animals; Arginine; Cell Culture Techniques; Cell Membrane; Cell Size; Cells, Cultured; Diabetes Mell | 2010 |
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
Topics: Animals; Anthraquinones; Aspartic Acid Endopeptidases; Blood Glucose; Blood Urea Nitrogen; Connexin | 2011 |
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Diabetes Mellitus, | 2011 |
[Effect of topical application of aminoguanidine cream on skin tissue of rats with diabetes].
Topics: Administration, Cutaneous; Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Glycation E | 2011 |
Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats.
Topics: Alloxan; Animals; Dental Implants; Dental Prosthesis Retention; Diabetes Mellitus, Experimental; Enz | 2011 |
Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats.
Topics: Animals; Antigens; Apoptosis; bcl-2-Associated X Protein; Blood Glucose; Cell Count; Diabetes Mellit | 2011 |
Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model.
Topics: Administration, Oral; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2011 |
Resorcylidene aminoguanidine (RAG) improves cardiac mitochondrial bioenergetics impaired by hyperglycaemia in a model of experimental diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electron Transport; Energy Metabolism; Enzy | 2011 |
Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats.
Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; beta-Galactosidase; Blood Glucose; Curcumin; Diabe | 2012 |
Anti-fibrotic cardio protective efficacy of aminoguanidine against streptozotocin induced cardiac fibrosis and high glucose induced collagen up regulation in cardiac fibroblasts.
Topics: Animals; Cardiotonic Agents; Collagen; Diabetes Mellitus, Experimental; Fibrosis; Gene Expression Re | 2012 |
Hypoxia in the diabetic kidney is independent of advanced glycation end-products.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inh | 2013 |
Beneficial effects of aminoguanidine on skin flap survival in diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Femal | 2012 |
Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes.
Topics: Aldehydes; Animals; Arginine; Calcium; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Ca | 2013 |
Effect of age receptor blocker and/or anti-inflammatory coadministration in relation to glycation, oxidative stress and cytokine production in stz diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Glucose; Cytokines; Diabetes Mel | 2002 |
Effects of aminoguanidine on glomerular basement membrane thickness and anionic charge in a diabetic rat model.
Topics: Administration, Oral; Animals; Basement Membrane; Diabetes Mellitus, Experimental; Disease Models, A | 2001 |
Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2002 |
ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
Topics: Amides; Animals; Animals, Genetically Modified; Blood Pressure; Body Weight; Diabetes Mellitus, Expe | 2002 |
Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme | 2002 |
Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.
Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic | 2002 |
[Effect of wenjingtong composita on blood glucose and advanced glycosylation end products in sciatic nerve of streptozotocin-induced diabetic rats].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drugs, Chinese Herba | 2002 |
ACE inhibition salvages the visual loss caused by diabetes.
Topics: Algorithms; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diab | 2003 |
Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature.
Topics: Acetylcholine; Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Endotheliu | 2003 |
Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice.
Topics: Angiography; Animals; Collagen; Collagenases; Collateral Circulation; Diabetes Mellitus, Experimenta | 2003 |
The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Inhibitors; Guanidines; Immu | 2003 |
Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine.
Topics: Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Benzoates; Blood Glucose; Body We | 2003 |
Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Dia | 2004 |
Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cataract; Deoxyguanosine; Diabetes Mellitus, Experimental; Dia | 2004 |
The role of advanced glycation in reduced organic cation transport associated with experimental diabetes.
Topics: Animals; Cations; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Guanidines; Mal | 2004 |
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.
Topics: Actins; Animals; Aorta; Arteriosclerosis; Collagen; Cytokines; Diabetes Mellitus, Experimental; Diab | 2004 |
Davis BJ, Forbes JM, Thomas MC et al. (2004) Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. Diabetologia 47:89-97.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2004 |
The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Erectile Dysfunction; Glycation End Pro | 2004 |
[Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Guanidines; Immunohistochemistry; Kid | 2004 |
Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats.
Topics: Animals; Aspirin; Blotting, Western; Cattle; Cell Death; Cells, Cultured; Cyclooxygenase 2; Diabetes | 2004 |
Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matri | 2004 |
Inducible nitric oxide synthase activity and expression in liver and hepatocytes of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Guanidines; Hepatocytes; In Vitro Techniques; Insulin; Liv | 2005 |
[Aminoguanidine prevents peroxynitrite production and cardiac hypertrophy in streptozotocin-induced diabetic rats].
Topics: Animals; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycation End Products, A | 2004 |
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabe | 2005 |
Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes.
Topics: Amino Acids; Animals; Antioxidants; Carbon; Cerebral Cortex; Chromatography, High Pressure Liquid; D | 2005 |
Modulating the effects of diabetes on osseointegration with aminoguanidine and doxycycline.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Dental Implantation, Endosseous; Dental Implan | 2005 |
From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy.
Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neph | 2005 |
Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors | 2006 |
Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine.
Topics: Adipose Tissue; Amine Oxidase (Copper-Containing); Animals; Appetite Depressants; Brain; Diabetes Me | 2006 |
Collagen ultrastructure and TGF-beta1 expression preserved with aminoguanidine during wound healing in diabetic rats.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Epithelium; Extrac | 2005 |
Transmission electron microscopy and autofluorescence findings in the cornea of diabetic rats treated with aminoguanidine.
Topics: Animals; Cornea; Corneal Diseases; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme I | 2006 |
The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; G | 2006 |
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gu | 2006 |
Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cardiac Output; Diabetes Mellitus, Experimental; Diabete | 2006 |
Effect of aminoguanidine treatment on diabetes-induced changes in the myenteric plexus of rat ileum.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Guanidines; Ileu | 2007 |
Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Blotting, Western; Cornus; Creatinine; Diabetes Mellit | 2007 |
Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Becaplermin; Cell Movement; Cell Proli | 2007 |
Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
Topics: Adult; Animals; Antibodies; Cells, Cultured; Culture Media, Conditioned; Diabetes Mellitus, Experime | 2007 |
The role of nitric oxide in diabetes-induced changes of morphine tolerance in rats.
Topics: Analgesics, Opioid; Animals; Arginine; Diabetes Mellitus, Experimental; Drug Tolerance; Guanidines; | 2007 |
Protective effect of Liuwei Dihuang decoction on early diabetic nephropathy induced by streptozotocin via modulating ET-ROS axis and matrix metalloproteinase activity in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; | 2007 |
Inhibitors of advanced glycation end-products prevent loss of enteric neuronal nitric oxide synthase in diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Duodenum; E | 2008 |
Upregulated endothelin system in diabetic vascular dysfunction and early retinopathy is reversed by CPU0213 and total triterpene acids from Fructus Corni.
Topics: Animals; Aorta, Thoracic; Aspartic Acid Endopeptidases; Cornus; Diabetes Mellitus, Experimental; Dia | 2007 |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme | 2008 |
Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies.
Topics: Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Electro | 2008 |
[Advanced glycation end products and their receptors elevate the activity of endothelin-1 in rat cavernosum].
Topics: Animals; Diabetes Mellitus, Experimental; Endothelin-1; Enzyme Inhibitors; Glycation End Products, A | 2008 |
[Peculiarities of L-arginine metabolism in the blood leukocytes in experimental diabetes mellitus].
Topics: Animals; Arginase; Arginine; Diabetes Mellitus, Experimental; Guanidines; Leukocytes; Male; Nitric O | 2008 |
The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothe | 2008 |
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Glucose; Body Temperature; Body Weight; Cortico | 1994 |
Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model.
Topics: Administration, Oral; Animals; Arterioles; Blood Glucose; Body Weight; Diabetes Mellitus, Experiment | 1995 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; B | 1993 |
Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice.
Topics: Agmatine; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Guanidines | 1995 |
Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats.
Topics: Animals; Basement Membrane; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Diabetic Re | 1995 |
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydrox | 1995 |
Effect of aminoguanidine on the impaired nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Expe | 1994 |
In vivo assessment of an animal model of diabetic cataract: medical intervention studies.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease Models | 1994 |
Active and passive mechanical properties of isolated arterioles from STZ-induced diabetic rats. Effect of aminoguanidine treatment.
Topics: Acetylcholine; Animals; Arterioles; Biomechanical Phenomena; Calcium; Diabetes Mellitus, Experimenta | 1994 |
Reversal of diabetes by intrapancreatic injection of aminoguanidine liposomes.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Carriers; Guanidines; Injections; Liposomes; Male; Pa | 1994 |
Aminoguanidine reduces regional albumin clearance but not urinary albumin excretion in streptozotocin-diabetic rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Eye; Gl | 1994 |
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat.
Topics: Aneurysm; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1994 |
Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats.
Topics: Animals; Capillary Permeability; Carotid Arteries; Diabetes Mellitus, Experimental; Elasticity; Glyc | 1993 |
Aminoguanidine, a potential drug for the treatment of diabetic complications.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Guanidines; Hum | 1993 |
Correction of erythrocyte deformability defect in ALX-induced diabetic rabbits after treatment with aminoguanidine.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocyte Deformability; Guanidines; Male | 1993 |
In vitro advanced glycation end product formation in rat tail tendon fibers: influence of aminoguanidine.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Glucose; Glycation End Products, Advanced; Guani | 1995 |
Effect of aminoguanidine on the frequency of neuroaxonal dystrophy in the superior mesenteric sympathetic autonomic ganglia of rats with streptozocin-induced diabetes.
Topics: Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Ganglia, | 1996 |
Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats.
Topics: Animals; Blood Pressure; Captopril; Collagen; Diabetes Mellitus, Experimental; Diastole; Guanidines; | 1996 |
Aminoguanidine and diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Guanidines; Motor Neurons; Neural C | 1996 |
Slowing of peripheral motor nerve conduction was ameliorated by aminoguanidine in streptozocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fructo | 1996 |
Effects of heparin and aminoguanidine on glomerular basement membrane thickening in diabetic rats.
Topics: Administration, Oral; Animals; Basement Membrane; Diabetes Mellitus, Experimental; Diabetic Nephropa | 1996 |
Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Aorta; Butylated Hydroxy | 1996 |
Inhibition of cataracts in moderately diabetic rats by aminoguanidine.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Progression; Glycation End Products, Adv | 1996 |
Rapid reversal by aminoguanidine of the neurovascular effects of diabetes in rats: modulation by nitric oxide synthase inhibition.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1996 |
Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; | 1996 |
Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Carnitine; Diabetes Mellitus, Experimental; Diabetic N | 1996 |
Chronic dosing with aminoguanidine and novel advanced glycosylation end product-formation inhibitors ameliorates cross-linking of tail tendon collagen in STZ-induced diabetic rats.
Topics: Aminobenzoates; Animals; Benzoates; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Experimenta | 1996 |
Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Blood Pressure; Body Weight; Capillaries; Ca | 1997 |
Endothelial dysfunction in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Coloring Agents; Diabetes Mellitus, Experimenta | 1996 |
Aminoguanidine--effects on endoneurial vasoactive nitric oxide and on motor nerve conduction velocity in control and streptozotocin-diabetic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Di | 1997 |
Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products.
Topics: Animals; Blotting, Northern; Body Weight; Collagen; Diabetes Mellitus, Experimental; DNA Probes; Ext | 1997 |
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.
Topics: Animals; Cardiovirus Infections; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Encepha | 1997 |
Effects of aminoguanidine on structural alterations of microvessels in peripheral nerve of streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanidine | 1997 |
Effects of aminoguanidine and N(G)-nitro-L-arginine methyl ester on vascular responses of aortae and lungs from streptozotocin-diabetic rats.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascula | 1997 |
NK cells, macrophages, and humoral immune responses are dominant in primary nonfunction of islet grafts in the dog-to-rat xenotransplant model.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Antilymphocyte Serum; B-Lymphocytes; Blood Gluc | 1997 |
Aminoguanidine inhibits the generation of nitric oxide in vitro and prolongs islet xenograft survival in rats.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gamma Rays; Graft | 1997 |
Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cattle; Diabetes Mellitus, Experimental; Diabetic Angiop | 1997 |
Aminoguanidine prolongs survival in azotemic-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Glycation End P | 1997 |
Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats.
Topics: Administration, Oral; Albuminuria; Animals; Cohort Studies; Diabetes Mellitus, Experimental; Enzyme | 1997 |
Aminoguanidine and the prevention of leukocyte dysfunction in diabetes mellitus: a direct vital microscopic study.
Topics: Alloxan; Animals; Biological Factors; Cell Adhesion; Diabetes Mellitus, Experimental; Endothelium, V | 1997 |
Aminoguanidine inhibits semicarbazide-sensitive amine oxidase activity: implications for advanced glycation and diabetic complications.
Topics: Amine Oxidase (Copper-Containing); Animals; Aorta; Diabetes Mellitus, Experimental; Enzyme Inhibitor | 1997 |
Immunochemical evidence for increased formation of advanced glycation end products and inhibition by aminoguanidine in diabetic rat lenses.
Topics: Animals; Antibody Specificity; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; G | 1997 |
Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA Damage; Guanidines; Insulin | 1998 |
Arteriolar reactivity in conscious diabetic rats: influence of aminoguanidine treatment.
Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Blood Glucose; Blood Pressure; Consciousness; Cr | 1998 |
Circulating advanced glycation peptides in streptozotocin-induced diabetic rats: evidence for preferential modification of IgG light chains.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Glycation E | 1998 |
Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Hydrogen Peroxid | 1998 |
Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relation | 1998 |
[Inhibition of lipid peroxidation in erythrocytes by aminoguanidine, resorcylidine aminoguanidine and their oxygen and sulfur analogs in diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Erythrocytes; Guanidines; In Vitro Tech | 1998 |
Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Glycate | 1998 |
Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes.
Topics: Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Erythrocytes; Glutat | 1998 |
Depletion of nitric oxide synthase-containing neurons in the diabetic retina: reversal by aminoguanidine.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzym | 1998 |
Effect of aminoguanidine on the generation of superoxide anion and nitric oxide by peripheral blood granulocytes of rats with streptozotocin-induced diabetes.
Topics: Animals; Anions; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycated Hemoglobin; G | 1998 |
Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding.
Topics: Animals; Autoradiography; Binding Sites; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gl | 1999 |
Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats.
Topics: Albuminuria; Animals; Arginine; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Enzyme Inh | 1999 |
Only limited effects of aminoguanidine treatment on peripheral nerve function, (Na+,K+)-ATPase activity and thrombomodulin expression in streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Male | 1999 |
Microvascular permeability change induced by platelet-activating factor is impaired in diabetic mice.
Topics: Animals; Azo Compounds; Capillary Permeability; Coloring Agents; Cyclooxygenase Inhibitors; Diabetes | 1999 |
Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructosamin | 1999 |
Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Erythrocytes; Gl | 1999 |
Aminoguanidine prevents impaired healing and deficient angiogenesis in diabetic rats.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Male; | 1999 |
Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.
Topics: Albuminuria; Animals; Antihypertensive Agents; Cathepsins; Diabetes Mellitus, Experimental; Enzyme I | 2000 |
SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy.
Topics: Animals; Antibody Specificity; Blotting, Northern; Diabetes Mellitus, Experimental; Diabetic Angiopa | 2000 |
Aminoguanidine suppresses basal macromolecular extravasation during diabetes mellitus.
Topics: Animals; Arterioles; Biological Transport; Blood Glucose; Body Weight; Capillary Permeability; Cheek | 2000 |
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function.
Topics: Aging; Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2000 |
Influence of experimental diabetes on regulatory mechanisms of vascular response of rabbit carotid artery to acetylcholine.
Topics: Acetylcholine; Alloxan; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Diabetes | 2000 |
Improvement by aminoguanidine of insulin secretion from pancreatic islets grafted to syngeneic diabetic rats.
Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Guanidines; Insulin; Insulin Secretion; Isl | 2000 |
Role of nitric oxide in diabetes-induced attenuation of antinociceptive effect of morphine in mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Female; Guanidines; Male; Mice; Morphi | 2000 |
Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glycat | 2000 |
Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine.
Topics: Animals; Carotid Arteries; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endoth | 2000 |
Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cataract; Cysteine; Diabetes Mellitus, Experimental; Diabetic R | 2000 |
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia.
Topics: Animals; Apoptosis; Capillaries; Cell Survival; Diabetes Mellitus, Experimental; Diabetic Retinopath | 2000 |
p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence.
Topics: Animals; Benzaldehydes; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme In | 2000 |
Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet; Galactosemias; Glutathione; Gu | 2000 |
Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability.
Topics: Animals; Arginine; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Densitometry; Diabetes M | 2000 |
The effect of aminoguanidine on urinary heparan sulphate levels in experimental diabetes.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Guani | 2000 |
Renoprotective effects of a novel inhibitor of advanced glycation.
Topics: Animals; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inh | 2001 |
Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Capillary Permeability; Diabetes Mellitus, Experi | 2001 |
Gene expression of receptor for advanced glycosylation end products and its modulation by aminoguanidine in diabetic kidney tissue.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycation End Products, Advanced; Guani | 1998 |
Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erect | 2001 |
Protective effect of aminoguanidine upon capillary and submesothelial anionic sites.
Topics: Albuminuria; Animals; Anions; Basement Membrane; Capillary Permeability; Diabetes Mellitus, Experime | 2001 |
Ramipril and aminoguanidine restore renal lysosomal processing in streptozotocin diabetic rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Body Weight; Chrom | 2001 |
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Blood Glucose; Diabet | 2001 |
Contribution of endothelial nitric oxide synthase in the blunted renal responses to volume expansion in diabetic rats.
Topics: Animals; Blood Glucose; Blood Pressure; Blood Volume; Diabetes Mellitus, Experimental; Enzyme Inhibi | 2001 |
Impaired relaxation in aorta from streptozotocin-diabetic rats: effect of aminoguanidine (AMNG) treatment.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes | 2000 |
The effect of aminoguanidine on diabetes-induced inactivation of kidney Na(+),K(+)- ATPase in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Kidney; Oxidation-Reduction | 2001 |
Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy.
Topics: Animals; Autoradiography; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Ex | 2001 |
Correction of early subnormal superior hemiretinal DeltaPO(2) predicts therapeutic efficacy in experimental diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; E | 2001 |
Advanced glycosylation end products, protein kinase C and renal alterations in diabetic rats.
Topics: Animals; Basement Membrane; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Glycated Hem | 2000 |
Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Fem | 2002 |
Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes.
Topics: Animals; Antioxidants; Calbindins; Carrier Proteins; Cell Count; cis-trans-Isomerases; Diabetes Mell | 2001 |
Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; | 2002 |
Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.
Topics: Aldehyde Reductase; Animals; Arginine; Arterioles; Diabetes Mellitus, Experimental; Enzyme Inhibitor | 2002 |
Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Base Sequence; Diabetes Mellitus, Experimental; D | 2002 |
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamid | 1992 |
Glycosylation of proteins and microangiopathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Gl | 1992 |
Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glycation End Products, Advanced; Guanidines; In | 1992 |
Effect of administration of aminoguanidine on viscosity of erythrocyte suspensions from rats with chronic streptozotocin-induced diabetes mellitus.
Topics: Animals; Blood Viscosity; Diabetes Mellitus, Experimental; Erythrocytes; Guanidines; Male; Rats; Rat | 1992 |
Collagen and bladder function in streptozotocin-diabetic rats: effects of insulin and aminoguanidine.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Guanidines; Insulin; Male; Rats; Rats, Inbred St | 1992 |
Aminoguanidine treatment reduces the increase in collagen stability of rats with experimental diabetes mellitus.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Energy Intake; Guanidines; Male; | 1992 |
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats.
Topics: Albuminuria; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; | 1992 |
Effect of aminoguanidine on functional and structural abnormalities in peripheral nerve of STZ-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycate | 1992 |
Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fluorescein Angiography; Glycosylati | 1991 |
The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blood-Retinal Barrier; Diabetes Mellitus, Experimental; Fluorophotometry; Gu | 1991 |
Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fluorescence; Glomeru | 1991 |
Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, | 1991 |
Inhibition of diabetes-associated complications by nucleophilic compounds.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Reti | 1991 |
Prevention of glomerular basement membrane thickening by aminoguanidine in experimental diabetes mellitus.
Topics: Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Guanidines; Kidney; Kidn | 1991 |
Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glycosylation; Guanidines; Male; Ni | 1991 |
Monoaminoguanidine prevents sorbitol accumulation, nonenzymatic protein glycosylation and development of kidney lesions in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycos | 1991 |
Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals.
Topics: Action Potentials; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Neurop | 1991 |
The effect of substance L on glucose-mediated cross-links of collagen in the diabetic db/db mouse.
Topics: Administration, Oral; Amino Acids; Animals; Collagen; Diabetes Mellitus, Experimental; Electrophores | 1990 |
Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin.
Topics: Aging; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Guani | 1990 |
Advanced glycosylation end-products in experimental murine diabetic nephropathy: effect of islet isografting and of aminoguanidine.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Glycosylation; Guanidines; | 1989 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Topics: Animals; Arteries; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; Glucose; Guanidines | 1986 |