pimagedine has been researched along with Albuminuria in 20 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined whether the prevention of diabetes-related albuminuria by aminoguanidine (AG) or ramipril (RAM) may be mediated by a common post-glomerular basement membrane renal intracellular mechanism involving protein kinase C (PKC)." | 7.70 | Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. ( Clavant, SP; Comper, WD; Jerums, G; Kemp, BE; Kiriazis, Z; Osicka, TM; Panagiotopoulos, S; Pike, RN; Pratt, LM; Russo, LM; Yu, Y, 2000) |
| " Both aminoguanidine and perindopril retarded the increase in albuminuria, which was completely abrogated by combination therapy." | 3.72 | Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. ( Allen, TJ; Burns, WC; Cooper, ME; Davis, BJ; Forbes, JM; Jerums, G; Kawachi, H; Thomas, MC, 2004) |
| "This study examined whether the prevention of diabetes-related albuminuria by aminoguanidine (AG) or ramipril (RAM) may be mediated by a common post-glomerular basement membrane renal intracellular mechanism involving protein kinase C (PKC)." | 3.70 | Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. ( Clavant, SP; Comper, WD; Jerums, G; Kemp, BE; Kiriazis, Z; Osicka, TM; Panagiotopoulos, S; Pike, RN; Pratt, LM; Russo, LM; Yu, Y, 2000) |
| "Malondialdehyde (MDA) content was significantly elevated and activities of SOD and catalase decreased in the kidneys of STZ-diabetic rats." | 1.30 | Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney. ( Kedziora-Kornatowska, K; Luciak, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abo-Salem, OM | 1 |
| Yu, PH | 1 |
| Wang, M | 1 |
| Deng, YL | 1 |
| Fan, H | 1 |
| Shira-Bock, L | 1 |
| Jerums, G | 6 |
| Panagiotopoulos, S | 3 |
| Forbes, J | 1 |
| Osicka, T | 1 |
| Cooper, M | 2 |
| Davis, BJ | 1 |
| Forbes, JM | 1 |
| Thomas, MC | 1 |
| Burns, WC | 1 |
| Kawachi, H | 1 |
| Allen, TJ | 1 |
| Cooper, ME | 3 |
| Soulis-Liparota, T | 2 |
| Dunlop, M | 1 |
| Vlassara, H | 1 |
| Striker, LJ | 1 |
| Teichberg, S | 1 |
| Fuh, H | 1 |
| Li, YM | 1 |
| Steffes, M | 1 |
| Huijberts, MS | 1 |
| Wolffenbuttel, BH | 1 |
| Crijns, FR | 1 |
| Nieuwenhuijzen Kruseman, AC | 1 |
| Bemelmans, MH | 1 |
| Struijker Boudier, HA | 1 |
| Nyengaard, JR | 1 |
| Chang, K | 1 |
| Berhorst, S | 1 |
| Reiser, KM | 1 |
| Williamson, JR | 1 |
| Tilton, RG | 1 |
| Yamauchi, A | 1 |
| Takei, I | 1 |
| Makita, Z | 1 |
| Nakamoto, S | 1 |
| Ohashi, N | 1 |
| Kiguchi, H | 1 |
| Ishii, T | 1 |
| Koike, T | 1 |
| Saruta, T | 1 |
| Viberti, G | 1 |
| Slama, G | 1 |
| Pozza, G | 1 |
| Czyzyk, A | 1 |
| Bilous, RW | 1 |
| Gries, A | 1 |
| Keen, H | 1 |
| Fuller, JH | 1 |
| Menzinger, G | 1 |
| Soulis, T | 1 |
| Sastra, S | 1 |
| Thallas, V | 1 |
| Bjerrum, OJ | 1 |
| Kedziora-Kornatowska, K | 1 |
| Luciak, M | 1 |
| Degenhardt, TP | 1 |
| Fu, MX | 1 |
| Voss, E | 1 |
| Reiff, K | 1 |
| Neidlein, R | 1 |
| Strein, K | 1 |
| Thorpe, SR | 1 |
| Baynes, JW | 1 |
| Reiter, R | 1 |
| Osicka, TM | 1 |
| Yu, Y | 1 |
| Clavant, SP | 1 |
| Kiriazis, Z | 1 |
| Pike, RN | 1 |
| Pratt, LM | 1 |
| Russo, LM | 1 |
| Kemp, BE | 1 |
| Comper, WD | 1 |
| Arai, T | 1 |
| Morimoto, K | 1 |
| Oka, M | 1 |
| Hikita, T | 1 |
| Arai, K | 1 |
| Umezawa, K | 1 |
| Nagase, M | 1 |
| Yamamoto, T | 1 |
| Shostak, A | 1 |
| Wajsbrot, V | 1 |
| Gotloib, L | 1 |
| Brownlee, M | 2 |
| Edelstein, D | 1 |
| Papazoglou, D | 1 |
| Clarke, B | 1 |
| Itakura, M | 1 |
| Yoshikawa, H | 1 |
| Bannai, C | 1 |
| Kato, M | 1 |
| Kunika, K | 1 |
| Kawakami, Y | 1 |
| Yamaoka, T | 1 |
| Yamashita, K | 1 |
1 review available for pimagedine and Albuminuria
| Article | Year |
|---|---|
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 2; Diabetic | 2003 |
19 other studies available for pimagedine and Albuminuria
| Article | Year |
|---|---|
The protective effect of aminoguanidine on doxorubicin-induced nephropathy in rats.
Topics: Acetylglucosamine; Albuminuria; Animals; Antibiotics, Antineoplastic; Blood Urea Nitrogen; Catalase; | 2012 |
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
Topics: Albuminuria; Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Arteriosclerosis; | 2002 |
Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Dia | 2004 |
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydrox | 1995 |
Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.
Topics: Aging; Albuminuria; Animals; Glomerulonephritis; Glycation End Products, Advanced; Guanidines; Male; | 1994 |
Aminoguanidine reduces regional albumin clearance but not urinary albumin excretion in streptozotocin-diabetic rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Eye; Gl | 1994 |
Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Blood Pressure; Body Weight; Capillaries; Ca | 1997 |
Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dise | 1997 |
Early closure of European Pimagedine trial. Steering Committee. Safety Committee.
Topics: Albuminuria; Contracts; Drug Industry; Enzyme Inhibitors; Ethics, Medical; Europe; Guanidines; Human | 1997 |
Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats.
Topics: Administration, Oral; Albuminuria; Animals; Cohort Studies; Diabetes Mellitus, Experimental; Enzyme | 1997 |
Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Glycate | 1998 |
Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats.
Topics: Albuminuria; Animals; Arginine; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Enzyme Inh | 1999 |
Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.
Topics: Albuminuria; Animals; Antihypertensive Agents; Cathepsins; Diabetes Mellitus, Experimental; Enzyme I | 2000 |
Aminoguanidine induces haematuria of non-glomerular origin in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Arterioles; Blood Pressure; Creatinine; Glomerulonephritis; Guanidines; Hematu | 2000 |
Protective effect of aminoguanidine upon capillary and submesothelial anionic sites.
Topics: Albuminuria; Animals; Anions; Basement Membrane; Capillary Permeability; Diabetes Mellitus, Experime | 2001 |
Glycosylation of proteins and microangiopathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Gl | 1992 |
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats.
Topics: Albuminuria; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; | 1992 |
Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fluorescence; Glomeru | 1991 |
Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, | 1991 |