Page last updated: 2024-10-22

pimagedine and Aging

pimagedine has been researched along with Aging in 43 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
"It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens."	7.71	Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002)
"It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging."	7.70	Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999)
"N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes."	7.69	Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997)
"It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens."	3.71	Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002)
"It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging."	3.70	Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999)
"N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes."	3.69	Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997)
" One such glycoxidation crosslink, pentosidine, has been used as a biomarker for aging studies because of its accumulation on the structural protein collagen."	3.69	Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hens. ( Iqbal, M; Klandorf, H; Probert, LL, 1997)
"AGEs accumulate in renal failure as a result of decreased excretion and increased generation resulting from oxidative and carbonyl stress of uremia."	2.41	Advanced glycation end products: a Nephrologist's perspective. ( Choudhury, D; Levi, M; Raj, DS; Welbourne, TC, 2000)
"Aging is associated with cardiac hypertrophy and arterial stiffening possibly associated with accumulation of advanced glycation end products (AGEs)."	1.30	Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. ( Bruneval, P; Corman, B; Duriez, M; Heudes, D; Levy, BI; Poitevin, P; Tedgui, A, 1998)
" In contrast, raising the ambient oxygen tension in the incubation environment to 95% lowered the LD50 dose of spermidine required for cytotoxicity."	1.27	Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. ( Hegre, OD; Hickey, GE; Marshall, S, 1984)

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.33)	18.7374
1990's	18 (41.86)	18.2507
2000's	20 (46.51)	29.6817
2010's	4 (9.30)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fleming, TH	1
Theilen, TM	1
Masania, J	1
Wunderle, M	1
Karimi, J	1
Vittas, S	1
Bernauer, R	1
Bierhaus, A	1
Rabbani, N	1
Thornalley, PJ	1
Kroll, J	1
Tyedmers, J	1
Nawrotzki, R	1
Herzig, S	1
Brownlee, M	1
Nawroth, PP	1
Micans, P	1
Zhang, S	1
Dong, Z	1
Peng, Z	1
Lu, F	1
Semba, RD	1
Nicklett, EJ	1
Ferrucci, L	1
Aronson, D	2
Nabekura, T	1
Koizumi, Y	1
Nakao, M	1
Tomohiro, M	1
Inomata, M	2
Ito, Y	2
Miller, AG	1
Meade, SJ	1
Gerrard, JA	1
Hayashi, M	1
Matsubara, Y	1
Takehana, M	1
Kawashima, S	1
Shumiya, S	1
Chang, KC	2
Hsu, KL	2
Peng, YI	1
Lee, FC	1
Tseng, YZ	2
Vasan, S	1
Foiles, P	1
Founds, H	1
Yang, B	1
Larson, DF	1
Watson, RR	1
Chou, TF	1
Lo, HM	1
Moreau, R	1
Nguyen, BT	1
Doneanu, CE	1
Hagen, TM	1
Zhong, W	1
Wang, LL	1
Cui, H	1
Li, S	1
Clément, P	1
Sarda, N	1
Cespuglio, R	1
Gharib, A	1
Reddy, VP	1
Beyaz, A	1
Hegre, OD	1
Marshall, S	1
Hickey, GE	1
Wu, G	1
Klandorf, H	4
Holt, SB	1
McGowan, JA	1
Pinchasov, Y	1
Deyette, D	1
Peterson, RA	1
Vlassara, H	3
Striker, LJ	1
Teichberg, S	1
Fuh, H	2
Li, YM	3
Steffes, M	2
Monnier, V	1
Donnelly, T	1
Liu, C	1
Basgen, J	1
Bucala, R	2
Malik, NS	1
Meek, KM	1
Tsukahara, H	1
Miura, M	1
Tsuchida, S	1
Hata, I	1
Hata, K	1
Yamamoto, K	1
Ishii, Y	1
Muramatsu, I	1
Sudo, M	1
Schleicher, ED	1
Wagner, E	1
Nerlich, AG	1
Iqbal, M	3
Probert, LL	2
Corman, B	2
Duriez, M	1
Poitevin, P	1
Heudes, D	1
Bruneval, P	1
Tedgui, A	1
Levy, BI	1
Oudes, AJ	1
Herr, CM	1
Olsen, Y	1
Fleming, JE	1
Carlsson, PO	1
Sandler, S	1
Jansson, L	1
Yamada, S	1
Ohkubo, C	1
Alhumadi, NH	1
Reckelhoff, JF	1
Hennington, BS	1
Kanji, V	1
Racusen, LC	1
Schmidt, AM	1
Yan, SD	1
Morrow, J	1
Roberts, LJ	1
Salahudeen, AK	1
Song, X	1
Bao, M	1
Li, D	1
Birrell, AM	1
Heffernan, SJ	1
Ansselin, AD	1
McLennan, S	1
Church, DK	1
Gillin, AG	1
Yue, DK	1
Raj, DS	1
Choudhury, D	1
Welbourne, TC	1
Levi, M	1
Kenney, PB	1
Al-Humadi, NH	1
Stitt, AW	1
Sell, DR	1
Nelson, JF	1
Monnier, VM	1
Cantini, C	1
Kieffer, P	1
Limiñana, P	1
Atkinson, J	1
Lartaud-Idjouadiene, I	1
Min, BH	1
Kim, HJ	1
Lim, H	1
Park, CS	1
Park, SR	1
Makita, Z	1
Rayfield, E	1
Cartwright, K	1
Friedman, E	1
Rodby, R	1
Cerami, A	1
Odetti, PR	1
Borgoglio, A	1
De Pascale, A	1
Rolandi, R	1
Adezati, L	1

Reviews

8 reviews available for pimagedine and Aging

Article	Year
Does accumulation of advanced glycation end products contribute to the aging phenotype? The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:9 Topics: Aging; Bone and Bones; Brain; Diet; Enzyme Inhibitors; Erythrocytes; Eye; Food Analysis; Glycation E	2010
Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. Journal of hypertension, 2003, Volume: 21, Issue:1 Topics: Aging; Animals; Arteries; Collagen; Diabetes Mellitus; Diastole; Elasticity; Glycation End Products,	2003
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks. Archives of biochemistry and biophysics, 2003, Nov-01, Volume: 419, Issue:1 Topics: Aging; Animals; Clinical Trials as Topic; Cross-Linking Reagents; Diabetes Mellitus; Diastole; Drug	2003
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:1 Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Product	2005
Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases. Drug discovery today, 2006, Volume: 11, Issue:13-14 Topics: Aging; Animals; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Guanidines; Humans; Hyp	2006
[Non-enzymatic glycosylation of proteins. Complications of diabetes mellitus, aging and kidney failure]. Presse medicale (Paris, France : 1983), 1993, Oct-09, Volume: 22, Issue:30 Topics: Aging; Arginine; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Glycation End Products, Ad	1993
Advanced glycation end products: a Nephrologist's perspective. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2000, Volume: 35, Issue:3 Topics: Aging; Arteriosclerosis; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Adv	2000
Advanced glycation: an important pathological event in diabetic and age related ocular disease. The British journal of ophthalmology, 2001, Volume: 85, Issue:6 Topics: Aging; Animals; Cataract; Diabetic Retinopathy; Enzyme Inhibitors; Glaucoma; Glycation End Products,	2001

Trials

2 trials available for pimagedine and Aging

Article	Year
Aortic wave velocity: a noninvasive method to measure the stiffness of arteries and the clinical results of supplements that appear to improve arterial stiffness. Current aging science, 2013, Volume: 6, Issue:1 Topics: Adult; Aged; Aging; Arginine; Cardiovascular Diseases; Carnosine; Dietary Supplements; Female; Glyca	2013
Relationship between mechanical properties and pentosidine in tendon: effects of age, diet restriction, and aminoguanidine in broiler breeder hens. Poultry science, 2000, Volume: 79, Issue:9 Topics: Aging; Animals; Arginine; Biomechanical Phenomena; Chickens; Diet; Elasticity; Female; Food Deprivat	2000

Other Studies

33 other studies available for pimagedine and Aging

Article	Year
Aging-dependent reduction in glyoxalase 1 delays wound healing. Gerontology, 2013, Volume: 59, Issue:5 Topics: Aging; Animals; Cells, Cultured; Down-Regulation; Fibroblasts; Guanidines; Lactoylglutathione Lyase;	2013
Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose. PloS one, 2014, Volume: 9, Issue:5 Topics: Adipose Tissue; Aging; Animals; Cell Differentiation; Cell Lineage; Cell Survival; Collagen; Culture	2014
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine. Experimental eye research, 2003, Volume: 76, Issue:2 Topics: Aging; Animals; Antioxidants; Calcium; Cataract; Crystallins; Disulfiram; Enzyme Inhibitors; Eye Dis	2003
New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics. Bioorganic & medicinal chemistry, 2003, Mar-20, Volume: 11, Issue:6 Topics: Aging; Animals; Catalysis; Cattle; Cross-Linking Reagents; Dimyristoylphosphatidylcholine; Electroph	2003
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). Current eye research, 2002, Volume: 25, Issue:4 Topics: Aging; alpha-Crystallin A Chain; Animals; Antibodies; Blotting, Western; Calpain; Case-Control Studi	2002
Aminoguanidine prevents age-related aortic stiffening in Fisher 344 rats: aortic impedance analysis. British journal of pharmacology, 2003, Volume: 140, Issue:1 Topics: Aging; Animals; Aorta; Cardiac Output; Guanidines; Heart Rate; Male; Rats; Rats, Inbred F344	2003
Modulation of iNOS activity in age-related cardiac dysfunction. Life sciences, 2004, Jun-25, Volume: 75, Issue:6 Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresce	2004
Pharmacological prevention of cardiovascular aging--targeting the Maillard reaction. British journal of pharmacology, 2004, Volume: 142, Issue:7 Topics: Aging; Animals; Cardiovascular Diseases; Coronary Vessels; Elasticity; Glycation End Products, Advan	2004
Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats. British journal of pharmacology, 2004, Volume: 142, Issue:7 Topics: Aging; Animals; Blood Pressure; Coronary Vessels; Glycation End Products, Advanced; Guanidines; Hear	2004
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats. Biochemical pharmacology, 2005, Jan-01, Volume: 69, Issue:1 Topics: Aging; Amino Acid Sequence; Animals; Cardiovascular System; Glucose; Guanidines; Lipid Peroxidation;	2005
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats. Neuroscience, 2005, Volume: 135, Issue:2 Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Brain; Electrochemistry; Electr	2005
Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. In vitro, 1984, Volume: 20, Issue:3 Pt 1 Topics: Aging; Animals; Benzylamine Oxidase; Cattle; Cell Line; Cell Survival; Chickens; Guanidines; Horses;	1984
Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes, 1995, Volume: 44, Issue:3 Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Diabetes Mellitus, Type 1; Guanidines; Male; N	1995
Hyperglycemia and non-enzymatic glycation of serum and tissue proteins in chickens. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995, Volume: 110, Issue:2 Topics: Administration, Oral; Aging; Analysis of Variance; Animals; Basement Membrane; Blood Glucose; Chicke	1995
Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. Proceedings of the National Academy of Sciences of the United States of America, 1994, Nov-22, Volume: 91, Issue:24 Topics: Aging; Albuminuria; Animals; Glomerulonephritis; Glycation End Products, Advanced; Guanidines; Male;	1994
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-30, Volume: 93, Issue:9 Topics: Acetylcholine; Aging; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Creatinine; Enzyme	1996
Vitamins and analgesics in the prevention of collagen ageing. Age and ageing, 1996, Volume: 25, Issue:4 Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cellula	1996
Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats. The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 1 Topics: Absorptiometry, Photon; Aging; Animals; Blood Pressure; Body Weight; Bone and Bones; Bone Density; E	1996
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. The Journal of clinical investigation, 1997, Feb-01, Volume: 99, Issue:3 Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch	1997
Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hens. Poultry science, 1997, Volume: 76, Issue:11 Topics: Aging; Analysis of Variance; Animals; Arginine; Blood Glucose; Chickens; Collagen; Diet; Egg Shell;	1997
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-03, Volume: 95, Issue:3 Topics: Aging; Animals; Aorta; Blood Pressure; Cardiac Output; Cardiomegaly; Carotid Arteries; Elasticity; E	1998
Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster. Mechanisms of ageing and development, 1998, Feb-16, Volume: 100, Issue:3 Topics: Aging; Animals; Drosophila melanogaster; Glycation End Products, Advanced; Guanidines; Longevity; Ma	1998
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase. Endocrinology, 1998, Volume: 139, Issue:8 Topics: Aging; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Colon; Diabetes Mellitus, Type 1	1998
The influence of frequent and excessive intake of glucose on microvascular aging in healthy mice. Microcirculation (New York, N.Y. : 1994), 1999, Volume: 6, Issue:1 Topics: Aging; Animals; Body Weight; Energy Intake; Enzyme Inhibitors; Glucose; Glycation End Products, Adva	1999
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution? The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:4 Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme	1999
Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats. American journal of hypertension, 1999, Volume: 12, Issue:5 Topics: Aging; Animals; Biomarkers; Blotting, Western; Dinoprost; Disease Models, Animal; Enzyme Inhibitors;	1999
Advanced glycation in D-galactose induced mouse aging model. Mechanisms of ageing and development, 1999, May-17, Volume: 108, Issue:3 Topics: Aging; Animals; Avoidance Learning; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Erythr	1999
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function. Diabetologia, 2000, Volume: 43, Issue:1 Topics: Aging; Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di	2000
Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat. The journals of gerontology. Series A, Biological sciences and medical sciences, 2001, Volume: 56, Issue:9 Topics: Aging; Animals; Collagen; Glycation End Products, Advanced; Glycosylation; Guanidines; Male; Oxidati	2001
Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:4 Topics: Aging; Animals; Aorta; Aorta, Thoracic; Blood Glucose; Blood Pressure; Body Weight; Calcium; Collage	2001
Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes. Experimental & molecular medicine, 2001, Dec-31, Volume: 33, Issue:4 Topics: Aging; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagen Type II; Enzyme Inhibitors; Gua	2001
Hemoglobin-AGE: a circulating marker of advanced glycosylation. Science (New York, N.Y.), 1992, Oct-23, Volume: 258, Issue:5082 Topics: Adult; Aging; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immuno	1992
Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin. Diabetes, 1990, Volume: 39, Issue:7 Topics: Aging; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Guani	1990

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