pimagedine has been researched along with Aging in 43 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens." | 7.71 | Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002) |
| "It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging." | 7.70 | Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 7.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens." | 3.71 | Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002) |
| "It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging." | 3.70 | Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 3.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| " One such glycoxidation crosslink, pentosidine, has been used as a biomarker for aging studies because of its accumulation on the structural protein collagen." | 3.69 | Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hens. ( Iqbal, M; Klandorf, H; Probert, LL, 1997) |
| "AGEs accumulate in renal failure as a result of decreased excretion and increased generation resulting from oxidative and carbonyl stress of uremia." | 2.41 | Advanced glycation end products: a Nephrologist's perspective. ( Choudhury, D; Levi, M; Raj, DS; Welbourne, TC, 2000) |
| "Aging is associated with cardiac hypertrophy and arterial stiffening possibly associated with accumulation of advanced glycation end products (AGEs)." | 1.30 | Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. ( Bruneval, P; Corman, B; Duriez, M; Heudes, D; Levy, BI; Poitevin, P; Tedgui, A, 1998) |
| " In contrast, raising the ambient oxygen tension in the incubation environment to 95% lowered the LD50 dose of spermidine required for cytotoxicity." | 1.27 | Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. ( Hegre, OD; Hickey, GE; Marshall, S, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.33) | 18.7374 |
| 1990's | 18 (41.86) | 18.2507 |
| 2000's | 20 (46.51) | 29.6817 |
| 2010's | 4 (9.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleming, TH | 1 |
| Theilen, TM | 1 |
| Masania, J | 1 |
| Wunderle, M | 1 |
| Karimi, J | 1 |
| Vittas, S | 1 |
| Bernauer, R | 1 |
| Bierhaus, A | 1 |
| Rabbani, N | 1 |
| Thornalley, PJ | 1 |
| Kroll, J | 1 |
| Tyedmers, J | 1 |
| Nawrotzki, R | 1 |
| Herzig, S | 1 |
| Brownlee, M | 1 |
| Nawroth, PP | 1 |
| Micans, P | 1 |
| Zhang, S | 1 |
| Dong, Z | 1 |
| Peng, Z | 1 |
| Lu, F | 1 |
| Semba, RD | 1 |
| Nicklett, EJ | 1 |
| Ferrucci, L | 1 |
| Aronson, D | 2 |
| Nabekura, T | 1 |
| Koizumi, Y | 1 |
| Nakao, M | 1 |
| Tomohiro, M | 1 |
| Inomata, M | 2 |
| Ito, Y | 2 |
| Miller, AG | 1 |
| Meade, SJ | 1 |
| Gerrard, JA | 1 |
| Hayashi, M | 1 |
| Matsubara, Y | 1 |
| Takehana, M | 1 |
| Kawashima, S | 1 |
| Shumiya, S | 1 |
| Chang, KC | 2 |
| Hsu, KL | 2 |
| Peng, YI | 1 |
| Lee, FC | 1 |
| Tseng, YZ | 2 |
| Vasan, S | 1 |
| Foiles, P | 1 |
| Founds, H | 1 |
| Yang, B | 1 |
| Larson, DF | 1 |
| Watson, RR | 1 |
| Chou, TF | 1 |
| Lo, HM | 1 |
| Moreau, R | 1 |
| Nguyen, BT | 1 |
| Doneanu, CE | 1 |
| Hagen, TM | 1 |
| Zhong, W | 1 |
| Wang, LL | 1 |
| Cui, H | 1 |
| Li, S | 1 |
| Clément, P | 1 |
| Sarda, N | 1 |
| Cespuglio, R | 1 |
| Gharib, A | 1 |
| Reddy, VP | 1 |
| Beyaz, A | 1 |
| Hegre, OD | 1 |
| Marshall, S | 1 |
| Hickey, GE | 1 |
| Wu, G | 1 |
| Klandorf, H | 4 |
| Holt, SB | 1 |
| McGowan, JA | 1 |
| Pinchasov, Y | 1 |
| Deyette, D | 1 |
| Peterson, RA | 1 |
| Vlassara, H | 3 |
| Striker, LJ | 1 |
| Teichberg, S | 1 |
| Fuh, H | 2 |
| Li, YM | 3 |
| Steffes, M | 2 |
| Monnier, V | 1 |
| Donnelly, T | 1 |
| Liu, C | 1 |
| Basgen, J | 1 |
| Bucala, R | 2 |
| Malik, NS | 1 |
| Meek, KM | 1 |
| Tsukahara, H | 1 |
| Miura, M | 1 |
| Tsuchida, S | 1 |
| Hata, I | 1 |
| Hata, K | 1 |
| Yamamoto, K | 1 |
| Ishii, Y | 1 |
| Muramatsu, I | 1 |
| Sudo, M | 1 |
| Schleicher, ED | 1 |
| Wagner, E | 1 |
| Nerlich, AG | 1 |
| Iqbal, M | 3 |
| Probert, LL | 2 |
| Corman, B | 2 |
| Duriez, M | 1 |
| Poitevin, P | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Tedgui, A | 1 |
| Levy, BI | 1 |
| Oudes, AJ | 1 |
| Herr, CM | 1 |
| Olsen, Y | 1 |
| Fleming, JE | 1 |
| Carlsson, PO | 1 |
| Sandler, S | 1 |
| Jansson, L | 1 |
| Yamada, S | 1 |
| Ohkubo, C | 1 |
| Alhumadi, NH | 1 |
| Reckelhoff, JF | 1 |
| Hennington, BS | 1 |
| Kanji, V | 1 |
| Racusen, LC | 1 |
| Schmidt, AM | 1 |
| Yan, SD | 1 |
| Morrow, J | 1 |
| Roberts, LJ | 1 |
| Salahudeen, AK | 1 |
| Song, X | 1 |
| Bao, M | 1 |
| Li, D | 1 |
| Birrell, AM | 1 |
| Heffernan, SJ | 1 |
| Ansselin, AD | 1 |
| McLennan, S | 1 |
| Church, DK | 1 |
| Gillin, AG | 1 |
| Yue, DK | 1 |
| Raj, DS | 1 |
| Choudhury, D | 1 |
| Welbourne, TC | 1 |
| Levi, M | 1 |
| Kenney, PB | 1 |
| Al-Humadi, NH | 1 |
| Stitt, AW | 1 |
| Sell, DR | 1 |
| Nelson, JF | 1 |
| Monnier, VM | 1 |
| Cantini, C | 1 |
| Kieffer, P | 1 |
| Limiñana, P | 1 |
| Atkinson, J | 1 |
| Lartaud-Idjouadiene, I | 1 |
| Min, BH | 1 |
| Kim, HJ | 1 |
| Lim, H | 1 |
| Park, CS | 1 |
| Park, SR | 1 |
| Makita, Z | 1 |
| Rayfield, E | 1 |
| Cartwright, K | 1 |
| Friedman, E | 1 |
| Rodby, R | 1 |
| Cerami, A | 1 |
| Odetti, PR | 1 |
| Borgoglio, A | 1 |
| De Pascale, A | 1 |
| Rolandi, R | 1 |
| Adezati, L | 1 |
8 reviews available for pimagedine and Aging
| Article | Year |
|---|---|
Does accumulation of advanced glycation end products contribute to the aging phenotype?
Topics: Aging; Bone and Bones; Brain; Diet; Enzyme Inhibitors; Erythrocytes; Eye; Food Analysis; Glycation E | 2010 |
Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes.
Topics: Aging; Animals; Arteries; Collagen; Diabetes Mellitus; Diastole; Elasticity; Glycation End Products, | 2003 |
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks.
Topics: Aging; Animals; Clinical Trials as Topic; Cross-Linking Reagents; Diabetes Mellitus; Diastole; Drug | 2003 |
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes].
Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Product | 2005 |
Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Guanidines; Humans; Hyp | 2006 |
[Non-enzymatic glycosylation of proteins. Complications of diabetes mellitus, aging and kidney failure].
Topics: Aging; Arginine; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Glycation End Products, Ad | 1993 |
Advanced glycation end products: a Nephrologist's perspective.
Topics: Aging; Arteriosclerosis; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Adv | 2000 |
Advanced glycation: an important pathological event in diabetic and age related ocular disease.
Topics: Aging; Animals; Cataract; Diabetic Retinopathy; Enzyme Inhibitors; Glaucoma; Glycation End Products, | 2001 |
2 trials available for pimagedine and Aging
| Article | Year |
|---|---|
Aortic wave velocity: a noninvasive method to measure the stiffness of arteries and the clinical results of supplements that appear to improve arterial stiffness.
Topics: Adult; Aged; Aging; Arginine; Cardiovascular Diseases; Carnosine; Dietary Supplements; Female; Glyca | 2013 |
Relationship between mechanical properties and pentosidine in tendon: effects of age, diet restriction, and aminoguanidine in broiler breeder hens.
Topics: Aging; Animals; Arginine; Biomechanical Phenomena; Chickens; Diet; Elasticity; Female; Food Deprivat | 2000 |
33 other studies available for pimagedine and Aging
| Article | Year |
|---|---|
Aging-dependent reduction in glyoxalase 1 delays wound healing.
Topics: Aging; Animals; Cells, Cultured; Down-Regulation; Fibroblasts; Guanidines; Lactoylglutathione Lyase; | 2013 |
Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose.
Topics: Adipose Tissue; Aging; Animals; Cell Differentiation; Cell Lineage; Cell Survival; Collagen; Culture | 2014 |
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
Topics: Aging; Animals; Antioxidants; Calcium; Cataract; Crystallins; Disulfiram; Enzyme Inhibitors; Eye Dis | 2003 |
New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics.
Topics: Aging; Animals; Catalysis; Cattle; Cross-Linking Reagents; Dimyristoylphosphatidylcholine; Electroph | 2003 |
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).
Topics: Aging; alpha-Crystallin A Chain; Animals; Antibodies; Blotting, Western; Calpain; Case-Control Studi | 2002 |
Aminoguanidine prevents age-related aortic stiffening in Fisher 344 rats: aortic impedance analysis.
Topics: Aging; Animals; Aorta; Cardiac Output; Guanidines; Heart Rate; Male; Rats; Rats, Inbred F344 | 2003 |
Modulation of iNOS activity in age-related cardiac dysfunction.
Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresce | 2004 |
Pharmacological prevention of cardiovascular aging--targeting the Maillard reaction.
Topics: Aging; Animals; Cardiovascular Diseases; Coronary Vessels; Elasticity; Glycation End Products, Advan | 2004 |
Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats.
Topics: Aging; Animals; Blood Pressure; Coronary Vessels; Glycation End Products, Advanced; Guanidines; Hear | 2004 |
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
Topics: Aging; Amino Acid Sequence; Animals; Cardiovascular System; Glucose; Guanidines; Lipid Peroxidation; | 2005 |
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Brain; Electrochemistry; Electr | 2005 |
Spermidine cytotoxicity in vitro: effect of serum and oxygen tension.
Topics: Aging; Animals; Benzylamine Oxidase; Cattle; Cell Line; Cell Survival; Chickens; Guanidines; Horses; | 1984 |
Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Diabetes Mellitus, Type 1; Guanidines; Male; N | 1995 |
Hyperglycemia and non-enzymatic glycation of serum and tissue proteins in chickens.
Topics: Administration, Oral; Aging; Analysis of Variance; Animals; Basement Membrane; Blood Glucose; Chicke | 1995 |
Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.
Topics: Aging; Albuminuria; Animals; Glomerulonephritis; Glycation End Products, Advanced; Guanidines; Male; | 1994 |
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.
Topics: Acetylcholine; Aging; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Creatinine; Enzyme | 1996 |
Vitamins and analgesics in the prevention of collagen ageing.
Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cellula | 1996 |
Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats.
Topics: Absorptiometry, Photon; Aging; Animals; Blood Pressure; Body Weight; Bone and Bones; Bone Density; E | 1996 |
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch | 1997 |
Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hens.
Topics: Aging; Analysis of Variance; Animals; Arginine; Blood Glucose; Chickens; Collagen; Diet; Egg Shell; | 1997 |
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.
Topics: Aging; Animals; Aorta; Blood Pressure; Cardiac Output; Cardiomegaly; Carotid Arteries; Elasticity; E | 1998 |
Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster.
Topics: Aging; Animals; Drosophila melanogaster; Glycation End Products, Advanced; Guanidines; Longevity; Ma | 1998 |
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase.
Topics: Aging; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Colon; Diabetes Mellitus, Type 1 | 1998 |
The influence of frequent and excessive intake of glucose on microvascular aging in healthy mice.
Topics: Aging; Animals; Body Weight; Energy Intake; Enzyme Inhibitors; Glucose; Glycation End Products, Adva | 1999 |
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme | 1999 |
Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats.
Topics: Aging; Animals; Biomarkers; Blotting, Western; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; | 1999 |
Advanced glycation in D-galactose induced mouse aging model.
Topics: Aging; Animals; Avoidance Learning; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Erythr | 1999 |
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function.
Topics: Aging; Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2000 |
Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat.
Topics: Aging; Animals; Collagen; Glycation End Products, Advanced; Glycosylation; Guanidines; Male; Oxidati | 2001 |
Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats.
Topics: Aging; Animals; Aorta; Aorta, Thoracic; Blood Glucose; Blood Pressure; Body Weight; Calcium; Collage | 2001 |
Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes.
Topics: Aging; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagen Type II; Enzyme Inhibitors; Gua | 2001 |
Hemoglobin-AGE: a circulating marker of advanced glycosylation.
Topics: Adult; Aging; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immuno | 1992 |
Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin.
Topics: Aging; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Guani | 1990 |