pimagedine has been researched along with Acute Disease in 25 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 7.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
| "The relation between ventricular histamine concentrations and the occurrence of early ventricular arrhythmias during acute myocardial ischaemia was investigated in pentobarbitone-anaesthetized rats." | 7.67 | Ventricular histamine concentrations and arrhythmias during acute myocardial ischaemia in rats. ( Dai, S, 1987) |
| "Histamine release could be shown in 50% of the dogs suffering from acute haemorrhagic pancreatitis in Pfeffer's preparation." | 7.66 | Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time. ( Kresse, U; Lange, E; Lorenz, W; Maroske, D; Neuhaus, H; Reimann, HJ; Schult, H; Schwarz, B, 1978) |
| " Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 3.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
| "The relation between ventricular histamine concentrations and the occurrence of early ventricular arrhythmias during acute myocardial ischaemia was investigated in pentobarbitone-anaesthetized rats." | 3.67 | Ventricular histamine concentrations and arrhythmias during acute myocardial ischaemia in rats. ( Dai, S, 1987) |
| "Histamine release could be shown in 50% of the dogs suffering from acute haemorrhagic pancreatitis in Pfeffer's preparation." | 3.66 | Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time. ( Kresse, U; Lange, E; Lorenz, W; Maroske, D; Neuhaus, H; Reimann, HJ; Schult, H; Schwarz, B, 1978) |
| " The optimal dosage of AG was screened by dry-wet weight method with the percentage of water content at 0, 12, 24, and 48 hours after injury." | 1.38 | [Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats]. ( Cao, Y; Fan, Z; Lü, G; Mei, X; Wang, Y; Yu, D; Zhang, M; Zhang, Z, 2012) |
| "Acute pulmonary thromboembolism increased mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance index (PVRI) by 21." | 1.34 | Aminoguanidine produces beneficial haemodynamic effects in a canine model of acute pulmonary thromboembolism. ( Dias-Junior, CA; Sertorio, JT; Tanus-Santos, JE, 2007) |
| "TNB-colitis was induced in rats with and without pretreatment with AG (200 mg kg-1 body weight in the drinking water)." | 1.31 | Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis. ( Adler, G; Bachem, M; Dikopoulos, N; Liptay, S; Nüssler, AK; Reinshagen, M; Schmid, RM; Stiegler, M; Weidenbach, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tinker, AC | 1 |
| Beaton, HG | 1 |
| Boughton-Smith, N | 1 |
| Cook, TR | 1 |
| Cooper, SL | 1 |
| Fraser-Rae, L | 1 |
| Hallam, K | 1 |
| Hamley, P | 1 |
| McInally, T | 1 |
| Nicholls, DJ | 1 |
| Pimm, AD | 1 |
| Wallace, AV | 1 |
| Franchin, M | 1 |
| Colón, DF | 1 |
| da Cunha, MG | 1 |
| Castanheira, FV | 1 |
| Saraiva, AL | 1 |
| Bueno-Silva, B | 1 |
| Alencar, SM | 1 |
| Cunha, TM | 1 |
| Rosalen, PL | 1 |
| Heinzel, FR | 1 |
| Gres, P | 1 |
| Boengler, K | 1 |
| Duschin, A | 1 |
| Konietzka, I | 1 |
| Rassaf, T | 1 |
| Snedovskaya, J | 1 |
| Meyer, S | 1 |
| Skyschally, A | 1 |
| Kelm, M | 1 |
| Heusch, G | 1 |
| Schulz, R | 1 |
| Fan, Z | 1 |
| Cao, Y | 1 |
| Zhang, Z | 1 |
| Wang, Y | 1 |
| Yu, D | 1 |
| Zhang, M | 1 |
| Mei, X | 1 |
| Lü, G | 1 |
| Enkhbaatar, P | 1 |
| Murakami, K | 1 |
| Shimoda, K | 1 |
| Mizutani, A | 1 |
| McGuire, R | 1 |
| Schmalstieg, F | 1 |
| Cox, R | 1 |
| Hawkins, H | 1 |
| Jodoin, J | 1 |
| Lee, S | 1 |
| Traber, L | 1 |
| Herndon, D | 1 |
| Traber, D | 1 |
| Al-Majed, AA | 1 |
| Khattab, M | 1 |
| Raza, M | 1 |
| Al-Shabanah, OA | 1 |
| Mostafa, AM | 1 |
| Coney, AM | 1 |
| Bishay, M | 1 |
| Marshall, JM | 1 |
| Cigremis, Y | 1 |
| Parlakpinar, H | 1 |
| Polat, A | 1 |
| Colak, C | 1 |
| Ozturk, F | 1 |
| Sahna, E | 1 |
| Ermis, N | 1 |
| Acet, A | 1 |
| Astolfi, RS | 1 |
| Khouri, DG | 1 |
| Brandizzi, LI | 1 |
| Avila-Campos, MJ | 1 |
| Andrade, HF | 1 |
| Dias-Junior, CA | 1 |
| Sertorio, JT | 1 |
| Tanus-Santos, JE | 1 |
| Arkovitz, MS | 1 |
| Wispé, JR | 1 |
| Garcia, VF | 1 |
| Szabó, C | 1 |
| Hock, CE | 1 |
| Yin, K | 1 |
| Yue, G | 1 |
| Wong, PY | 1 |
| Laudanno, OM | 1 |
| Cesolari, JA | 1 |
| San Miguel, P | 1 |
| Bedini, OA | 1 |
| Okuda, Y | 1 |
| Sakoda, S | 1 |
| Fujimura, H | 1 |
| Yanagihara, T | 1 |
| Schuiling, M | 1 |
| Meurs, H | 1 |
| Zuidhof, AB | 1 |
| Venema, N | 1 |
| Zaagsma, J | 1 |
| Vazquez-Torres, A | 1 |
| Jones-Carson, J | 1 |
| Wagner, RD | 1 |
| Warner, T | 1 |
| Balish, E | 1 |
| Cruz, WS | 1 |
| Corbett, JA | 1 |
| Longmore, WJ | 1 |
| Moxley, MA | 1 |
| Tanaka, N | 1 |
| Tanaka, K | 1 |
| Nagashima, Y | 1 |
| Kondo, M | 1 |
| Sekihara, H | 1 |
| Nishino, T | 1 |
| Watanabe, S | 1 |
| Oyama, H | 1 |
| Fukuya, Y | 1 |
| Hayashi, N | 1 |
| Kobayashi, M | 1 |
| Pozza, M | 1 |
| Bettelli, C | 1 |
| Aloe, L | 1 |
| Giardino, L | 1 |
| Calzà, L | 1 |
| Dikopoulos, N | 1 |
| Nüssler, AK | 1 |
| Liptay, S | 1 |
| Bachem, M | 1 |
| Reinshagen, M | 1 |
| Stiegler, M | 1 |
| Schmid, RM | 1 |
| Adler, G | 1 |
| Weidenbach, H | 1 |
| Demougeot, C | 1 |
| Garnier, P | 1 |
| Mossiat, C | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Ahmad, N | 1 |
| Chen, LC | 1 |
| Gordon, MA | 1 |
| Laskin, JD | 1 |
| Laskin, DL | 1 |
| Lange, E | 1 |
| Schult, H | 1 |
| Lorenz, W | 1 |
| Reimann, HJ | 1 |
| Maroske, D | 1 |
| Neuhaus, H | 1 |
| Schwarz, B | 1 |
| Kresse, U | 1 |
| Dai, S | 1 |
25 other studies available for pimagedine and Acute Disease
| Article | Year |
|---|---|
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Topics: Acute Disease; Administration, Oral; Amines; Animals; Arthritis, Experimental; Cell Line; Chronic Di | 2003 |
Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Brazil; CD4-Positive T-Ly | 2016 |
Inducible nitric oxide synthase expression and cardiomyocyte dysfunction during sustained moderate ischemia in pigs.
Topics: Acute Disease; Animals; Arginine; Calcium; Enzyme Inhibitors; Gene Expression Regulation, Enzymologi | 2008 |
[Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats].
Topics: Acute Disease; Animals; Aquaporin 4; Blood-Brain Barrier; Blotting, Western; Disease Models, Animal; | 2012 |
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Indazoles; Lu | 2003 |
Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Drug Syner | 2003 |
Influence of endogenous nitric oxide on sympathetic vasoconstriction in normoxia, acute and chronic systemic hypoxia in the rat.
Topics: Acute Disease; Animals; Chronic Disease; Electric Stimulation; Enzyme Inhibitors; Guanidines; Hindli | 2004 |
Beneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatment.
Topics: Acute Disease; Animals; Cardiomyopathies; Doxorubicin; Glutathione; Guanidines; Heart; Myocardium; N | 2006 |
Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis.
Topics: Acute Disease; Animals; Bacteroides fragilis; Bacteroides Infections; Disease Models, Animal; Escher | 2007 |
Aminoguanidine produces beneficial haemodynamic effects in a canine model of acute pulmonary thromboembolism.
Topics: Acute Disease; Animals; Blood Pressure; Cyclic GMP; Dogs; Female; Guanidines; Lung; Male; Models, An | 2007 |
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Drug Evalua | 1996 |
Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia.
Topics: Acute Disease; Animals; Endotoxemia; Enzyme Inhibitors; Guanidines; Hemodynamics; Lipopolysaccharide | 1997 |
[Role of inducible nitric oxide synthase in acute gastric mucosal damage in stress, in rats].
Topics: Acute Disease; Animals; Dexamethasone; Excitatory Amino Acid Agonists; Female; Gastric Mucosa; Guani | 1996 |
Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase.
Topics: Acute Disease; Animals; Autoimmune Diseases; Disease Progression; Drug Administration Schedule; Ence | 1998 |
Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs.
Topics: Acute Disease; Adjuvants, Immunologic; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronch | 1998 |
Early resistance of interleukin-10 knockout mice to acute systemic candidiasis.
Topics: Acute Disease; Animals; Candidiasis; Enzyme Inhibitors; Female; Guanidines; Immunity, Innate; Interl | 1999 |
Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats.
Topics: Acute Disease; Animals; Arteries; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Guanidines; Lung; | 1999 |
Nitric oxide increases hepatic arterial blood flow in rats with carbon tetrachloride-induced acute hepatic injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inhibit | 1999 |
An endothelial nitric oxide synthase inhibitor aggravates CDL-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Arginine; Ascitic Fluid; Duodenum; Edema; Enzyme Inhibitors; Guanidines; Lig | 1999 |
Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: aminoguanidine treatment modifies its clinical evolution.
Topics: Acute Disease; Animals; Brain; Demyelinating Diseases; Disease Progression; Encephalomyelitis, Autoi | 2000 |
Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Guanidines; Liver; Male; Neutrophil Infiltration; NF-kappa B | 2001 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia.
Topics: Acute Disease; Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |
Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time.
Topics: Acute Disease; Amine Oxidase (Copper-Containing); Animals; Disease Models, Animal; Dogs; Duodenum; F | 1978 |
Ventricular histamine concentrations and arrhythmias during acute myocardial ischaemia in rats.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Guanidines; Heart Ra | 1987 |