pimagedine has been researched along with Acute Brain Injuries in 18 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Daily treatment of AG at the dosage of 100 mg/kg or normal saline was given intraperitoneally into rats starting 2 h before or 30 min after brain injury." | 1.32 | Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study. ( Ling, EA; Lu, J; Moochhala, S; Moore, XL; Ng, KC; Shirhan, M; Tan, MH; Teo, AL; Wong, MC, 2003) |
| "After sham treatment, the necrosis expanded to 8." | 1.32 | Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult. ( Baethmann, A; Plesnila, N; Rinecker, M; Stoffel, M, 2003) |
| " bolus 10 min prior to trauma (300 mg/kg body weight; n = 10) and a second bolus of the same dosage intraperitoneally 1 h after trauma." | 1.31 | Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury. ( Baethmann, A; Eriskat, J; Plesnila, N; Rinecker, M; Stoffel, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 14 (77.78) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di, F | 1 |
| Yan-Ting, G | 1 |
| Hui, L | 1 |
| Tao, T | 1 |
| Zai-Hua, X | 1 |
| Xue-Ying, S | 1 |
| Hong-Li, X | 1 |
| Yun-Jie, W | 1 |
| Hao, W | 1 |
| Wu, XQ | 1 |
| Xu, RT | 1 |
| Fan, D | 1 |
| Gu, YT | 1 |
| Lv, H | 1 |
| Tang, T | 1 |
| Xu, ZH | 1 |
| Song, ZQ | 1 |
| Tong, XJ | 1 |
| Lu, J | 4 |
| Moochhala, S | 3 |
| Shirhan, M | 2 |
| Ng, KC | 3 |
| Tan, MH | 2 |
| Teo, AL | 3 |
| Ling, EA | 2 |
| Moore, XL | 1 |
| Wong, MC | 1 |
| Rinecker, M | 3 |
| Plesnila, N | 3 |
| Baethmann, A | 3 |
| Stoffel, M | 3 |
| Atan, MS | 1 |
| Moochhala, SM | 1 |
| Low, K | 1 |
| Zhao, P | 1 |
| Zuo, Z | 1 |
| Louin, G | 1 |
| Marchand-Verrecchia, C | 1 |
| Palmier, B | 1 |
| Plotkine, M | 2 |
| Jafarian-Tehrani, M | 1 |
| Wang, YB | 1 |
| Ou, SW | 1 |
| Li, GY | 1 |
| Liu, YH | 1 |
| Kawano, T | 1 |
| Kunz, A | 1 |
| Abe, T | 1 |
| Girouard, H | 1 |
| Anrather, J | 1 |
| Zhou, P | 1 |
| Iadecola, C | 1 |
| Lecanu, L | 1 |
| Verrecchia, C | 1 |
| Margaill, I | 1 |
| Boulu, RG | 1 |
| Wada, K | 1 |
| Chatzipanteli, K | 1 |
| Kraydieh, S | 1 |
| Busto, R | 1 |
| Dietrich, WD | 1 |
| Sinz, EH | 1 |
| Kochanek, PM | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Carcillo, JA | 1 |
| Schiding, JK | 1 |
| Chen, M | 1 |
| Wisniewski, SR | 1 |
| Carlos, TM | 1 |
| Williams, D | 1 |
| DeKosky, ST | 1 |
| Watkins, SC | 1 |
| Marion, DW | 1 |
| Billiar, TR | 1 |
| Görlach, C | 1 |
| Hortobágyi, T | 1 |
| Benyó, Z | 1 |
| Wahl, M | 1 |
| Eriskat, J | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for pimagedine and Acute Brain Injuries
| Article | Year |
|---|---|
Role of aminoguanidine in brain protection in surgical brain injury in rat.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain; Brain Chemistry; Brain Edema; Brain Injuries | 2008 |
The molecular mechanism of aminoguanidine-mediated reduction on the brain edema after surgical brain injury in rats.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationshi | 2009 |
The protective mechanism for the blood-brain barrier induced by aminoguanidine in surgical brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Glutathione; Guanidines; Humans; Male; Malondialdehyde | 2011 |
Nitric oxide induces macrophage apoptosis following traumatic brain injury in rats.
Topics: Animals; Apoptosis; Brain Injuries; Fluorescent Antibody Technique; Guanidines; Macrophages; Male; N | 2003 |
Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Protein | 2003 |
Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Guan | 2003 |
Application of combined magnetic resonance imaging and histopathologic and functional studies for evaluation of aminoguanidine following traumatic brain injury in rats.
Topics: Animals; Apoptosis; Brain; Brain Chemistry; Brain Injuries; Caspase 3; Caspases; Enzyme Inhibitors; | 2004 |
Effects of aminoguanidine and L-arginine methyl ester resuscitation following induction of fluid-percussion injury and severe controlled hemorrhagic shock in the rat brain.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; | 2004 |
Isoflurane preconditioning induces neuroprotection that is inducible nitric oxide synthase-dependent in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Gas Analysis; Blotting, Western; Body Weig | 2004 |
Selective inhibition of inducible nitric oxide synthase reduces neurological deficit but not cerebral edema following traumatic brain injury.
Topics: Amidines; Animals; Benzylamines; Blood-Brain Barrier; Body Water; Brain Edema; Brain Injuries; Enzym | 2006 |
Concentrations of nitric oxide in rat brain tissues after diffuse brain injury and neuroprotection by the selective inducible nitric oxide synthase inhibitor aminoguanidine.
Topics: Animals; Brain; Brain Injuries; Enzyme Inhibitors; Guanidines; Neuroprotective Agents; Nitric Oxide; | 2005 |
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.
Topics: Animals; Body Temperature; Brain; Brain Injuries; Carotid Arteries; Guanidines; Ischemic Preconditio | 2007 |
iNOS contribution to the NMDA-induced excitotoxic lesion in the rat striatum.
Topics: Animals; Brain Injuries; Corpus Striatum; Dexamethasone; Dizocilpine Maleate; Guanidines; Male; N-Me | 1998 |
Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.
Topics: Animals; Astrocytes; Brain Injuries; Enzyme Induction; Enzyme Inhibitors; Guanidines; Macrophages; M | 1998 |
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Cognition Disorders; Enzyme Induction; Enzyme Inhibi | 1999 |
Aminoguanidine reduces brain lesion volume after cold injury in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Mal | 2000 |
Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury.
Topics: Animals; Arginine; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Male; Nec | 2001 |
Attenuation of secondary lesion growth in the brain after trauma by selective inhibition of the inducible NO-synthase.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Enzyme Inhibitors; Gua | 2000 |