pilsicainide has been researched along with Brugada Syndrome in 32 studies
pilsicainide: structure given in first source
pilsicainide : A secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan.
Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilsicainide induced VA in some patients with Brugada syndrome, but this result may not be used as a parameter of the risk stratification of Brugada syndrome." | 7.74 | Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome. ( Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Komura, S; Tanabe, Y; Washizuka, T, 2007) |
| " We investigated the association between spontaneous ventricular fibrillation (VF) occurrence and TWA after pilsicainide, a sodium channel blocker administration in BS patients." | 5.13 | Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome. ( Banba, K; Kusano, KF; Miura, D; Morita, H; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Tada, T; Watanabe, A, 2008) |
| "We administered intravenous pilsicainide to 245 consecutive patients with Brugada syndrome (181 patients with spontaneous type 1 ECG, 64 patients with non-type 1 ECG)." | 3.88 | Prognostic Significance of the Sodium Channel Blocker Test in Patients With Brugada Syndrome. ( Ito, H; Kawada, S; Miyamoto, M; Morimoto, Y; Morita, H; Nakagawa, K; Nishii, N; Tachibana, M; Ueoka, A; Watanabe, A, 2018) |
| "Administration of pilsicainide, a class IC antiarrhythmic agent, caused Brugada- type ST elevation in a 66-year-old Japanese male who presented with paroxysmal atrial fibrillation (PAF), type I atrial flutter and inducible ventricular fibrillation (VF) during electrophysiological study." | 3.83 | A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG. ( Ai, T; Horie, M; Itoh, H; Makiyama, T; Shimizu, A; Turker, I; Ueyama, T; Vatta, M, 2016) |
| "Pilsicainide induced VA in some patients with Brugada syndrome, but this result may not be used as a parameter of the risk stratification of Brugada syndrome." | 3.74 | Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome. ( Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Komura, S; Tanabe, Y; Washizuka, T, 2007) |
| "Frequent premature ventricular complexes (PVCs) with two different left bundle branch block patterns developed during ST segment elevation." | 1.35 | Pilsicainide-induced ST segment elevation and ST segment depression in two patients with variant forms of Brugada-type electrocardiographic abnormalities. ( Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Tagawa, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (50.00) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Hasebe, H | 1 |
| Yokoya, T | 1 |
| Murakoshi, N | 1 |
| Kurebayashi, N | 1 |
| Kakihara, J | 1 |
| Takagi, M | 3 |
| Hayashi, Y | 1 |
| Tatsumi, H | 3 |
| Doi, A | 3 |
| Yoshiyama, M | 3 |
| Ueoka, A | 1 |
| Morita, H | 5 |
| Watanabe, A | 3 |
| Morimoto, Y | 1 |
| Kawada, S | 1 |
| Tachibana, M | 1 |
| Miyamoto, M | 1 |
| Nakagawa, K | 1 |
| Nishii, N | 3 |
| Ito, H | 1 |
| Nagayama, T | 1 |
| Nagase, S | 3 |
| Kamakura, T | 2 |
| Wada, M | 2 |
| Ishibashi, K | 2 |
| Inoue, YY | 1 |
| Miyamoto, K | 2 |
| Noda, T | 2 |
| Aiba, T | 2 |
| Takaki, H | 2 |
| Sugimachi, M | 1 |
| Shimizu, W | 2 |
| Noguchi, T | 1 |
| Yasuda, S | 2 |
| Kamakura, S | 2 |
| Kusano, K | 2 |
| Nakajima, I | 1 |
| Okamura, H | 1 |
| Ogawa, H | 1 |
| Makiyama, T | 2 |
| Kimura, T | 1 |
| Yamasaki, H | 1 |
| Tada, H | 1 |
| Sekiguchi, Y | 2 |
| Aonuma, K | 1 |
| Turker, I | 1 |
| Vatta, M | 1 |
| Itoh, H | 1 |
| Ueyama, T | 5 |
| Shimizu, A | 4 |
| Ai, T | 1 |
| Horie, M | 1 |
| Kofune, M | 2 |
| Watanabe, I | 2 |
| Ashino, S | 2 |
| Ohkubo, K | 2 |
| Okumura, Y | 2 |
| Kofune, T | 1 |
| Nakai, T | 2 |
| Hirayama, A | 2 |
| Omichi, C | 1 |
| Fujimoto, N | 1 |
| Kawasaki, A | 1 |
| Kasai, A | 1 |
| Chinushi, M | 2 |
| Tagawa, M | 1 |
| Izumi, D | 2 |
| Furushima, H | 2 |
| Aizawa, Y | 2 |
| Shimeno, K | 2 |
| Maeda, K | 2 |
| Nakagawa, E | 1 |
| Mizobuchi, M | 1 |
| Enjoji, Y | 1 |
| Nakamura, S | 1 |
| Muranishi, H | 1 |
| Utsunomiya, M | 1 |
| Funatsu, A | 1 |
| Kobayashi, T | 1 |
| Ogawa, R | 1 |
| Kishi, R | 2 |
| Takagi, A | 2 |
| Sakaue, I | 1 |
| Takahashi, H | 1 |
| Matsumoto, N | 1 |
| Masuhara, K | 1 |
| Nakazawa, K | 2 |
| Kobayashi, S | 1 |
| Miyake, F | 2 |
| Echizen, H | 1 |
| Zipes, DP | 2 |
| Morita, ST | 2 |
| Wu, J | 2 |
| Sugi, N | 3 |
| Yoshiga, Y | 3 |
| Doi, M | 1 |
| Ohmiya, T | 1 |
| Ohno, M | 1 |
| Yoshida, M | 1 |
| Matsuzaki, M | 4 |
| Hisada, T | 1 |
| Miyagawa, T | 1 |
| Yakushiji, T | 1 |
| Tsujimoto, T | 1 |
| Sakai, M | 1 |
| Adachi, T | 1 |
| Ikewaki, K | 1 |
| Ogata, K | 1 |
| Ohsuzu, F | 1 |
| Sakurai, Y | 1 |
| Nagashima, K | 1 |
| Kunimoto, S | 1 |
| Kasamaki, Y | 1 |
| Murata, K | 1 |
| Tanaka, T | 1 |
| Nose, Y | 1 |
| Wada, Y | 1 |
| Ikeda, T | 1 |
| Abe, A | 1 |
| Yusu, S | 1 |
| Nakamura, K | 3 |
| Ishiguro, H | 1 |
| Mera, H | 1 |
| Yotsukura, M | 1 |
| Yoshino, H | 1 |
| Yodogawa, K | 1 |
| Morita, N | 1 |
| Kobayashi, Y | 1 |
| Takayama, H | 1 |
| Ohara, T | 1 |
| Katoh, T | 1 |
| Takano, T | 1 |
| Yamagata, T | 1 |
| Esato, M | 2 |
| Ohmura, M | 1 |
| Kanemoto, M | 1 |
| Kametani, R | 1 |
| Sawa, A | 2 |
| Suzuki, S | 2 |
| Deschênes, I | 1 |
| Laurita, KR | 1 |
| Sakurai, T | 1 |
| Osada, K | 1 |
| Ryu, S | 1 |
| Fujita, S | 1 |
| Matsuda, H | 1 |
| Ishikawa, Y | 1 |
| Komura, S | 1 |
| Tanabe, Y | 1 |
| Washizuka, T | 1 |
| Yoshisato, T | 1 |
| Takeda, H | 1 |
| Tsuburaya, R | 1 |
| Endo, N | 1 |
| Niitsuma, T | 1 |
| Miura, E | 1 |
| Hirosaka, A | 1 |
| Owada, K | 1 |
| Tamagawa, K | 1 |
| Tada, T | 1 |
| Kusano, KF | 2 |
| Banba, K | 2 |
| Miura, D | 1 |
| Ohe, T | 2 |
| Kanemori, T | 1 |
| Shimizu, H | 1 |
| Oka, K | 1 |
| Furukawa, Y | 1 |
| Hiromoto, K | 1 |
| Mine, T | 1 |
| Masuyama, T | 1 |
| Ohyanagi, M | 1 |
| Madias, JE | 1 |
| Hiramatsu, S | 1 |
| Sakuragi, S | 1 |
4 trials available for pilsicainide and Brugada Syndrome
| Article | Year |
|---|---|
Different effect of the pure Na+ channel-blocker pilsicainide on the ST-segment response in the right precordial leads in patients with normal left ventricular function.
Topics: Adult; Aged; Algorithms; Brugada Syndrome; Electrocardiography; Female; Heart Diseases; Humans; Lido | 2007 |
Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography.
Topics: Adult; Aged; Arrhythmias, Cardiac; Biomarkers; Brugada Syndrome; Diagnosis, Differential; Electrocar | 2007 |
Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel | 2008 |
Sodium channel blockers enhance the temporal QT interval variability in the right precordial leads in Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Rate; H | 2008 |
28 other studies available for pilsicainide and Brugada Syndrome
| Article | Year |
|---|---|
Pilsicainide Administration Unmasks a Phenotype of Brugada Syndrome in a Patient with Overlap Syndrome due to the E1784K SCN5A Mutation.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Long QT Syn | 2020 |
Utility of 12-lead and signal-averaged Holter electrocardiograms after pilsicainide provocation for risk stratification in Brugada syndrome.
Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography, Ambulatory; Female; Humans; Lidocaine | 2017 |
Prognostic Significance of the Sodium Channel Blocker Test in Patients With Brugada Syndrome.
Topics: Administration, Intravenous; Adult; Aged; Brugada Syndrome; Death, Sudden, Cardiac; Electrocardiogra | 2018 |
Clinical and Electrocardiographic Differences in Brugada Syndrome With Spontaneous or Drug-Induced Type 1 Electrocardiogram.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Mal | 2019 |
Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, | 2016 |
Right coronary cusp as a new window of ablation for pilsicainide-induced ventricular premature contractions in a patient with Brugada syndrome.
Topics: Adult; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Ventricl | 2016 |
A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Base Sequence; Brugada Syndrome; | 2016 |
Action potential alternans in the right ventricular outflow tract in a patient with asymptomatic Brugada syndrome.
Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lido | 2009 |
Ischemia-induced Brugada-type ST-segment alternans and Brugada syndrome.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Brugada Syndrome; Bundle-Branch Block; Coronary Artery | 2010 |
Pilsicainide-induced ST segment elevation and ST segment depression in two patients with variant forms of Brugada-type electrocardiographic abnormalities.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Injections | 2009 |
A predictor of positive drug provocation testing in individuals with saddle-back type ST-segment elevation.
Topics: Action Potentials; Adult; Brugada Syndrome; Electrocardiography; Female; Humans; Infusions, Intraven | 2009 |
Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome.
Topics: Adult; Aged; Aged, 80 and over; Brugada Syndrome; Chi-Square Distribution; Electrocardiography; Fema | 2010 |
Conduction delay in right ventricle as a marker for identifying high-risk patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Coronary Sinus; Death, Sudden, Cardiac; Electrocard | 2010 |
A novel microsatellite polymorphism of sodium channel beta1-subunit gene (SCN1B) may underlie abnormal cardiac excitation manifested by coved-type ST-elevation compatible with Brugada syndrome in Japanese.
Topics: Adult; Age Factors; Aged; Asian People; Brugada Syndrome; Electrocardiography; Female; Genetic Predi | 2010 |
Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Body Surface Potential | 2010 |
What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease?
Topics: Brugada Syndrome; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Middle | 2010 |
Ventricular fibrillation diagnosed during electrophysiological study for non-sustained tachycardia.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Japan; Lidocaine; Male | 2010 |
A new criteria differentiating type 2 and 3 Brugada patterns from ordinary incomplete right bundle branch block.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Bundle-Branch Block; Diagnosis, Differential; Elect | 2011 |
Right ventricular dysfunction in patients with Brugada-like electrocardiography: a two dimensional strain imaging study.
Topics: Brugada Syndrome; Echocardiography; Elasticity Imaging Techniques; Electrocardiography; Female; Huma | 2011 |
The full stomach test as a novel diagnostic technique for identifying patients at risk of Brugada syndrome.
Topics: Adult; Brugada Syndrome; Circadian Rhythm; Electrocardiography; Electrophysiologic Techniques, Cardi | 2006 |
High-frequency potentials developed in wavelet-transformed electrocardiogram as a novel indicator for detecting Brugada syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; | 2006 |
Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome.
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electr | 2007 |
How can a single mutation cause such arrhythmic havoc?
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electr | 2007 |
Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome.
Topics: Adult; Aged; Arrhythmias, Cardiac; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniq | 2007 |
[Elderly Brugada syndrome with recurrent syncope, diagnosed by pilsicainide challenge test].
Topics: Aged; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Male; Recurrence; Syncope | 2007 |
Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia.
Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Catheter Ablation; Electrocardiography; Electrophysiologic | 2008 |
Re: Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel | 2008 |
Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome.
Topics: Action Potentials; Adult; Aged; Brugada Syndrome; Case-Control Studies; Electrocardiography; Endocar | 2008 |