pilocarpine has been researched along with Xerophthalmia in 7 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Xerophthalmia: Dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS." | 9.27 | Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial. ( Cifuentes, M; Del Barrio-Díaz, P; Vera-Kellet, C, 2018) |
| "During the past decade 2,436 patients with primary glaucoma were treated in the Budapest Eye Clinic." | 7.66 | [Glaucoma and the dry eye syndrome]. ( Follmann, P; Túri, E, 1980) |
| "To investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS." | 5.27 | Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial. ( Cifuentes, M; Del Barrio-Díaz, P; Vera-Kellet, C, 2018) |
| "Pilocarpine therapy is useful to improve xerostomia and xerophthalmia in SS patients with moderate and severe glandular involvement." | 3.72 | [Usefulness of oral pilocarpin therapy in the treatment of xerostomia and xerophthalmia in patients with primary Sjögren's syndrome]. ( Bosch, JA; Fonollosa, V; Selva, A; Simeón, CP; Solans, R; Vilardell, M, 2004) |
| "During the past decade 2,436 patients with primary glaucoma were treated in the Budapest Eye Clinic." | 3.66 | [Glaucoma and the dry eye syndrome]. ( Follmann, P; Túri, E, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cifuentes, M | 1 |
| Del Barrio-Díaz, P | 1 |
| Vera-Kellet, C | 1 |
| Solans, R | 1 |
| Bosch, JA | 1 |
| Selva, A | 1 |
| Simeón, CP | 1 |
| Fonollosa, V | 1 |
| Vilardell, M | 1 |
| Baudouin, C | 1 |
| Pisella, PJ | 1 |
| Brignole, F | 1 |
| Follmann, P | 1 |
| Túri, E | 1 |
| Takaya, M | 1 |
| Ichikawa, Y | 1 |
| Yamada, C | 1 |
| Hoshina, Y | 1 |
| Horiki, T | 1 |
| Uchiyama, M | 1 |
| Canapp, SO | 1 |
| Cohn, LA | 1 |
| Maggs, DJ | 1 |
| Miller, MA | 1 |
| Kerl, ME | 1 |
| O'Brien, DP | 1 |
| Severin, GA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome[NCT04470479] | Phase 3 | 32 participants (Actual) | Interventional | 2005-03-01 | Completed | ||
| Xerostomy Treatment in Patients With Sjogren's Syndrome in Chile :A Double Blind Control Trial Comparing Orally Pilocarpine Drops and Artificial Saliva[NCT00438048] | Phase 4 | 76 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pilocarpine and Xerophthalmia
| Article | Year |
|---|---|
[Current treatments of xerophthalmia in Sjögren's syndrome].
Topics: Administration, Topical; Anti-Infective Agents, Local; Cyclosporine; Gels; Humans; Immunosuppressive | 2004 |
Keratoconjunctivitis sicca.
Topics: Acetylcysteine; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Eyelids; Keratoconjunctivitis; Meth | 1973 |
2 trials available for pilocarpine and Xerophthalmia
| Article | Year |
|---|---|
Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial.
Topics: Administration, Oral; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarini | 2018 |
[Treatment with pilocarpine hydrochloride for sicca symptoms in Sjögren's syndrome].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Middle Aged; Parasympathomimetics; Pilocarpine; S | 1997 |
3 other studies available for pilocarpine and Xerophthalmia
| Article | Year |
|---|---|
[Usefulness of oral pilocarpin therapy in the treatment of xerostomia and xerophthalmia in patients with primary Sjögren's syndrome].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Male; Middle Aged; Miotics; Pilocarpine; Sjogren' | 2004 |
[Glaucoma and the dry eye syndrome].
Topics: Epithelium; Eye; Female; Glaucoma; Humans; Male; Microscopy, Electron; Ophthalmic Solutions; Pilocar | 1980 |
Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (Sjögren's-like syndrome) in a cat.
Topics: Animals; Anti-Bacterial Agents; Atropine; Biopsy; Cat Diseases; Cats; Clindamycin; Cornea; Deglutiti | 2001 |