pilocarpine has been researched along with Tremor in 24 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tremulous jaw movements in rats can be induced by several conditions associated with parkinsonism and tremorogenesis, including dopamine depletion, dopamine antagonism, and cholinomimetic drugs." | 7.78 | Extracellular GABA in globus pallidus increases during the induction of oral tremor by haloperidol but not by muscarinic receptor stimulation. ( Collins-Praino, LE; Kovner, R; Podurgiel, SJ; Randall, PA; Salamone, JD, 2012) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 7.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 7.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "Alterations of steady state and metabolism of putative neurotransmitters were studied in the brain of rats with a sustained tremor evoked by nicotine and pilocarpine." | 7.66 | Possible mechanisms of sustained tremor induction by nicotine in pilocarpine treated animals. ( Dohi, T; Tsujimoto, A, 1978) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 5.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| " Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic." | 3.81 | Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Morató, X; Stagljar, I, 2015) |
| "Tremulous jaw movements in rats can be induced by several conditions associated with parkinsonism and tremorogenesis, including dopamine depletion, dopamine antagonism, and cholinomimetic drugs." | 3.78 | Extracellular GABA in globus pallidus increases during the induction of oral tremor by haloperidol but not by muscarinic receptor stimulation. ( Collins-Praino, LE; Kovner, R; Podurgiel, SJ; Randall, PA; Salamone, JD, 2012) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 3.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 3.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| "Although most rodent studies related to parkinsonian symptoms have focused on locomotion, tremulous jaw movements also have been used as a rodent model of tremor for investigating the circuitry of the basal ganglia." | 3.72 | Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats. ( Arizzi, MN; Correa, M; Ishiwari, K; Salamone, JD; Wisniecki, A, 2003) |
| ") also potentiates oxotremorine-induced tremors in mice, in a dose-dependent manner, and this effect was completely prevented by atropine." | 3.71 | Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. ( Cunha, GM; Farias, PA; Viana, GS, 2002) |
| " The standard muscarinic agonists oxotremorine and pilocarpine were both active in these tests but showed little separation between efficacy and cholinergic side effects." | 3.70 | Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity. ( Bymaster, FP; Calligaro, DO; DeLapp, NW; Fink-Jensen, A; Jeppesen, L; Olesen, PH; Rasmussen, T; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Swedberg, MD; Thomsen, C; Thøgersen, H; Ward, JS, 1998) |
| " The non-selective muscarinic agonists pilocarpine, oxotremorine, RS-86, S-aceclidine, but not the less active isomer R-aceclidine, also effectively stimulated PI hydrolysis in mice." | 3.70 | Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. ( Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W, 1998) |
| "Rolipram, in contrast to the tricyclic antidepressants amitriptyline and imipramine or the acetylcholine receptor antagonist atropine, failed to antagonize the salivation, hypothermia, or tremor caused in mice by the muscarinic receptor agonists pilocarpine or oxotremorine." | 3.67 | Absence of anticholinergic activity of rolipram, an antidepressant with a novel mechanism of action, in three different animal models in vivo. ( Löschmann, PA; Pietzuch, P; Wachtel, H, 1988) |
| "Alterations of steady state and metabolism of putative neurotransmitters were studied in the brain of rats with a sustained tremor evoked by nicotine and pilocarpine." | 3.66 | Possible mechanisms of sustained tremor induction by nicotine in pilocarpine treated animals. ( Dohi, T; Tsujimoto, A, 1978) |
| " Carbachol or oxotremorine injected in small doses intracerebroventricularly into conscious mice caused hypothermia, gross tremor and a variety of parasympathomimetic effects including lachrymation and salivation." | 3.65 | Investigation of central cholinergic mechanisms in the conscious mouse. ( Ankier, SI; Brittain, RT; Jack, D, 1971) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 1.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sauerberg, P | 2 |
| Jeppesen, L | 2 |
| Olesen, PH | 1 |
| Rasmussen, T | 1 |
| Swedberg, MD | 1 |
| Sheardown, MJ | 2 |
| Fink-Jensen, A | 2 |
| Thomsen, C | 1 |
| Thøgersen, H | 1 |
| Rimvall, K | 2 |
| Ward, JS | 2 |
| Calligaro, DO | 2 |
| DeLapp, NW | 1 |
| Bymaster, FP | 2 |
| Shannon, HE | 2 |
| Collins-Praino, LE | 4 |
| Paul, NE | 1 |
| Ledgard, F | 1 |
| Podurgiel, SJ | 3 |
| Kovner, R | 2 |
| Baqi, Y | 2 |
| Müller, CE | 3 |
| Senatus, PB | 1 |
| Salamone, JD | 10 |
| Gandía, J | 1 |
| Morató, X | 1 |
| Stagljar, I | 1 |
| Fernández-Dueñas, V | 1 |
| Ciruela, F | 1 |
| Collins, LE | 1 |
| Galtieri, DJ | 1 |
| Brennum, LT | 1 |
| Sager, TN | 1 |
| Hockemeyer, J | 1 |
| Hinman, JR | 1 |
| Chrobak, JJ | 1 |
| Randall, PA | 2 |
| Pardo, M | 1 |
| Schwarzschild, MA | 1 |
| Correa, M | 4 |
| Podurgiel, S | 1 |
| Yohn, S | 1 |
| Roach, A | 1 |
| Lobianco, C | 1 |
| Wisniecki, A | 2 |
| Arizzi, MN | 1 |
| Ishiwari, K | 2 |
| Mingote, S | 1 |
| Trevitt, JT | 2 |
| Carlson, BB | 2 |
| Simola, N | 1 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Morelli, M | 1 |
| Betz, AJ | 1 |
| McLaughlin, PJ | 1 |
| Burgos, M | 1 |
| Weber, SM | 1 |
| Carter, PA | 1 |
| Peters, SC | 1 |
| Zhang, W | 1 |
| Mitch, CH | 1 |
| Whitesitt, CA | 1 |
| DeLapp, N | 1 |
| Mayorga, AJ | 2 |
| Cousins, MS | 1 |
| Conlan, A | 1 |
| Gianutsos, G | 1 |
| Nisenbaum, E | 1 |
| Nisenbaum, L | 1 |
| Felder, C | 1 |
| Cunha, GM | 1 |
| Farias, PA | 1 |
| Viana, GS | 1 |
| Pandit, PR | 1 |
| Kulkarni, S | 1 |
| Joglekar, GV | 1 |
| Dohi, T | 2 |
| Tsujimoto, A | 2 |
| Wachtel, H | 1 |
| Löschmann, PA | 1 |
| Pietzuch, P | 1 |
| Molnár, J | 1 |
| György, L | 1 |
| Pfeifer, KA | 1 |
| Nádor, K | 1 |
| Greco, JJ | 1 |
| Kelman, CD | 1 |
| Ankier, SI | 1 |
| Brittain, RT | 1 |
| Jack, D | 1 |
| Nakamura, R | 1 |
| Lindström, LH | 1 |
| Meyerson, BJ | 1 |
1 review available for pilocarpine and Tremor
| Article | Year |
|---|---|
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism.
Topics: Acetylcholine; Animals; Humans; Jaw; Mice; Mice, Knockout; Motor Activity; Muscarinic Agonists; Musc | 2001 |
23 other studies available for pilocarpine and Tremor
| Article | Year |
|---|---|
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Brain; Dopamine Antagonists; Drug Evaluation, Pre | 1998 |
Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism.
Topics: Adenosine A2 Receptor Antagonists; Animals; Deep Brain Stimulation; Disease Models, Animal; Dopamine | 2013 |
Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
Topics: Adenosine A2 Receptor Antagonists; Animals; Jaw; Male; Mice, Inbred C57BL; Mice, Knockout; Movement; | 2015 |
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Anima | 2010 |
Extracellular GABA in globus pallidus increases during the induction of oral tremor by haloperidol but not by muscarinic receptor stimulation.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; | 2012 |
Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Disease Models, Animal; Jaw; Male; | 2013 |
Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Dopamine Agonists; Locomotion; Male; Muscarini | 2013 |
Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats.
Topics: Animals; Behavior, Animal; Bicuculline; Depression, Chemical; Dose-Response Relationship, Drug; Drug | 2003 |
The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response R | 2004 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.
Topics: Animals; Atropine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; J | 2007 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic | 1998 |
Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats.
Topics: Animals; Corpus Striatum; Diamines; Dose-Response Relationship, Drug; Jaw; Male; Muscarinic Agonists | 1999 |
Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline.
Topics: Acetylcholinesterase; Animals; Anxiety; Avoidance Learning; Hippocampus; Learning Disabilities; Male | 2002 |
Comparative study of central and peripheral anticholinergic activities of antihistaminics in vivo in albino mice.
Topics: Animals; Arecoline; Female; Histamine H1 Antagonists; Humans; Hyperkinesis; Male; Mice; Nicotine; Pa | 1975 |
Possible mechanisms of sustained tremor induction by nicotine in pilocarpine treated animals.
Topics: Animals; Brain; Corpus Striatum; Dopamine; Fenclonine; Hemicholinium 3; Homovanillic Acid; Hydroxyin | 1978 |
Characteristics of sustained tremor induced by nicotine in pilocarpine-treated animals.
Topics: Animals; Brain Stem; Drug Synergism; Male; Nicotine; Pilocarpine; Rats; Temperature; Time Factors; T | 1976 |
Absence of anticholinergic activity of rolipram, an antidepressant with a novel mechanism of action, in three different animal models in vivo.
Topics: Animals; Antidepressive Agents; Body Temperature; Female; Mice; Oxotremorine; Parasympatholytics; Pi | 1988 |
Tremorigenic and convulsant actions of intracerebrally administered vegetative poisons in the mouse.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Carbachol; Central Nervous System Stimulants; Hist | 1967 |
Systemic pilocarpine toxicity in the treatment of angle closure glaucoma.
Topics: Aged; Bradycardia; Diarrhea; Glaucoma; Glycerol; Humans; Hypotension; Leukocytosis; Male; Nausea; Op | 1973 |
Investigation of central cholinergic mechanisms in the conscious mouse.
Topics: Acetylcholine; Amphetamine; Animals; Antidepressive Agents; Atropine; Brain; Carbachol; Cerebral Ven | 1971 |
[Studies on minor tremor of the eyeball].
Topics: Adult; Ciliary Body; Electroencephalography; Female; Humans; Male; Ophthalmoplegia; Picolinic Acids; | 1967 |
The effect of pilocarpine, oxotremorine and arecoline in combination with methyl-atropine or atropine on hormone activated oestrous behaviour in ovariectomized rats.
Topics: Animals; Atropa belladonna; Atropine; Castration; Depression, Chemical; Drug Synergism; Estradiol; E | 1967 |