pilocarpine has been researched along with Stomatitis in 11 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine has been approved for post-radiation xerostomia, and the effect of its use during radiation therapy on salivary flow, xerostomia, mucositis, and quality of life (QOL) was assessed in a phase III study conducted by the Radiation Therapy Oncology Group (RTOG 97-09)." | 2.72 | Effect of pilocarpine during radiation therapy: results of RTOG 97-09, a phase III randomized study in head and neck cancer patients. ( Brachman, D; Foote, R; Hodson, DI; Lee, N; LeVeque, F; Meredith, R; Scarantino, C; Schulsinger, A; Swann, RS; White, R, 2006) |
| "Pilocarpine hydrochloride has been reported to increase salivation and decrease oral mucositis in patients receiving head and neck radiotherapy, but there is only one report of its use in a cancer chemotherapy patient population." | 2.71 | Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantation. ( Brennan, MT; Fox, PC; Frenette, G; Kent, ML; Lockhart, PB; Norton, HJ; Packman, CH, 2005) |
| "Numerous regimens treat symptoms of xerostomia and associated caries and mucositis." | 2.40 | Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy. ( Garg, AK; Malo, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vissink, A | 1 |
| Burlage, FR | 1 |
| Spijkervet, FK | 1 |
| Jansma, J | 1 |
| Coppes, RP | 1 |
| SAVINSKAIA, AP | 1 |
| Lockhart, PB | 1 |
| Brennan, MT | 1 |
| Kent, ML | 1 |
| Packman, CH | 1 |
| Norton, HJ | 1 |
| Fox, PC | 1 |
| Frenette, G | 1 |
| Scarantino, C | 1 |
| LeVeque, F | 1 |
| Swann, RS | 1 |
| White, R | 1 |
| Schulsinger, A | 1 |
| Hodson, DI | 1 |
| Meredith, R | 1 |
| Foote, R | 1 |
| Brachman, D | 1 |
| Lee, N | 1 |
| Mikhaĭlov, VV | 3 |
| Rusanova, AG | 3 |
| Garg, AK | 1 |
| Malo, M | 1 |
| van der Rijt, CC | 1 |
| van Zuijlen, L | 1 |
| Awidi, A | 1 |
| Homsi, U | 1 |
| Kakail, RI | 1 |
| Mubarak, A | 1 |
| Hassan, A | 1 |
| Kelta, M | 1 |
| Martinez, P | 1 |
| Sulaiti, S | 1 |
| Al Qady, A | 1 |
| Jamhoury, A | 1 |
| Daniel, M | 1 |
| Charles, C | 1 |
| Ambrose, A | 1 |
| El-Aloosy, AS | 1 |
| Mead, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Yeur-Hur Lai, PhD, RN, School of Nursing, College of Medicine, National Taiwan University[NCT03883152] | 131 participants (Actual) | Observational | 2017-06-27 | Completed | |||
| A Phase III Study to Test the Efficacy of the Prophylactic Use of Oral Pilocarpine to Reduce Hyposalivation and Mucositis Associated With Curative Radiation Therapy in Head and Neck Cancer Patients[NCT00003139] | Phase 3 | 249 participants (Actual) | Interventional | 1998-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pilocarpine and Stomatitis
| Article | Year |
|---|---|
Prevention and treatment of the consequences of head and neck radiotherapy.
Topics: Anti-Bacterial Agents; Cranial Irradiation; Dental Caries; Dysgeusia; Head and Neck Neoplasms; Human | 2003 |
Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy.
Topics: Cariostatic Agents; Chronic Disease; Dental Caries; Fluorides; Gels; Head and Neck Neoplasms; Humans | 1997 |
3 trials available for pilocarpine and Stomatitis
| Article | Year |
|---|---|
Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantation.
Topics: Adult; Double-Blind Method; Female; Gingival Diseases; Hematologic Neoplasms; Humans; Male; Middle A | 2005 |
Effect of pilocarpine during radiation therapy: results of RTOG 97-09, a phase III randomized study in head and neck cancer patients.
Topics: Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Qualit | 2006 |
Double-blind, placebo-controlled cross-over study of oral pilocarpine for the prevention of chemotherapy-induced oral mucositis in adult patients with cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Double-Blind Method; Fema | 2001 |
6 other studies available for pilocarpine and Stomatitis
| Article | Year |
|---|---|
[Effect of an organic inflammatory focus in the oral cavity on pilocarpine secretion of the paired salivary glands].
Topics: Digestion; Pilocarpine; Salivary Glands; Stomatitis | 1957 |
[The interrelationship of the protein content of the tissue of the submandibular salivary glands and the mucosa during the secretory cycle in acute inflammation of the oral soft tissues].
Topics: Acute Disease; Animals; Bacterial Toxins; Female; Male; Mouth Mucosa; Pilocarpine; Rats; Saliva; Sal | 1993 |
[The interrelationship of the catecholamine and protein content of the tissue of the submandibular salivary glands and the mucosa during the secretory cycle in chronic inflammation of the oral soft tissues].
Topics: Animals; Carrageenan; Catecholamines; Chronic Disease; Female; Male; Mouth Mucosa; Pilocarpine; Rats | 1993 |
[Catecholamines in salivary gland and oral mucosal tissue and in the saliva in acute inflammation of the oral soft tissues].
Topics: Acute Disease; Animals; Catecholamines; Chromatography, High Pressure Liquid; Female; Male; Mouth Mu | 1993 |
Studies on supportive care in oral mucositis: random or randomised?
Topics: Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mouth Mucosa; Muscarinic Agonists; Oral Hy | 2001 |
Management of oral mucositis associated with cancer chemotherapy.
Topics: Antineoplastic Agents; Humans; Ice; Mouth Mucosa; Muscarinic Agonists; Neoplasms; Oral Hygiene; Pilo | 2002 |