pilocarpine has been researched along with Sjogren's Syndrome in 80 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS." | 9.27 | Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial. ( Cifuentes, M; Del Barrio-Díaz, P; Vera-Kellet, C, 2018) |
| " As genetic predisposition and ethnicity may alter the effectiveness of drug treatment, evaluation of the efficacy and safety of the secretagogue pilocarpine hydrochloride in the treatment of xerostomia in patients with SS in different populations is needed." | 9.12 | Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren's syndrome in Taiwan--a double-blind, placebo-controlled trial. ( Hsieh, SC; Lee, KL; Li, KJ; Lu, MC; Wu, CH; Yu, CL, 2006) |
| "The study of xerostomia using basal and pilocarpine SSF is simple to perform, acceptable to patients and needs no special equipment." | 9.10 | Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjögren's syndrome. Correlation with clinical, immunological and histological features. ( Caballero, O; Cervera, R; Ena, J; Font, J; García-Carrasco, M; Ingelmo, M; Pascual, E; Ramos-Casals, M; Rosas, J; Verdu, J, 2002) |
| "This review discusses the randomized trials available on the efficacy and tolerability of oral pilocarpine for the treatment of xerostomia." | 8.84 | Systemic pilocarpine for treatment of xerostomia. ( Berk, L, 2008) |
| "To analyze the role of oral pilocarpine in the treatment of xerostomia of Sjogren's syndrome (SS)." | 8.80 | The use of oral pilocarpine in xerostomia and Sjögren's syndrome. ( Nusair, S; Rubinow, A, 1999) |
| "Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS." | 7.91 | The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study. ( Chen, TH; Chen, YC; Hsu, CY; Hung, KC; Ko, CH; Lin, CY; Lin, MS; Lin, YS, 2019) |
| "To determine the prognostic value of a test using pilocarpine chloride to identify those patients with xerostomia who may achieve a long-term increase in SFR in response to acupuncture." | 7.70 | Prognostic value of the pilocarpine test to identify patients who may obtain long-term relief from xerostomia by acupuncture treatment. ( Blom, M; Kopp, S; Lundeberg, T, 1999) |
| " Identically appearing placebo solution with the same dosing schedule and duration was used for the control subjects." | 6.67 | Effects of pilocarpine on salivary flow in patients with Sjögren's syndrome. ( Rhodus, NL; Schuh, MJ, 1991) |
| " However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group." | 5.36 | Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren's syndrome. ( Kohno, Y; Kuwada, N; Nonaka, Y; Saito, K; Shimojo, N; Takei, S; Tomiita, M, 2010) |
| "Oral pilocarpine induced an increase in goblet cells number and an amelioration of conjunctival epithelium not dependent on tear secretion." | 5.33 | Conjunctival epithelium improvement after systemic pilocarpine in patients with Sjogren's syndrome. ( Aragona, P; Di Pietro, R; Mobrici, M; Spinella, R, 2006) |
| "Pilocarpine has been used as an ophthalmologic agent for decades; however, toxicity rarely has been reported in the medical literature." | 5.32 | Pilocarpine toxicity and the treatment of xerostomia. ( Greenberg, MI; Hendrickson, RG; Morocco, AP, 2004) |
| "Pilocarpine HCl has been shown to stimulate parotid and submandibular gland salivary flow." | 5.30 | Oral pilocarpine HCl stimulates labial (minor) salivary gland flow in patients with Sjögren's syndrome. ( Rhodus, NL, 1997) |
| "To investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS." | 5.27 | Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial. ( Cifuentes, M; Del Barrio-Díaz, P; Vera-Kellet, C, 2018) |
| " As genetic predisposition and ethnicity may alter the effectiveness of drug treatment, evaluation of the efficacy and safety of the secretagogue pilocarpine hydrochloride in the treatment of xerostomia in patients with SS in different populations is needed." | 5.12 | Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren's syndrome in Taiwan--a double-blind, placebo-controlled trial. ( Hsieh, SC; Lee, KL; Li, KJ; Lu, MC; Wu, CH; Yu, CL, 2006) |
| "The study of xerostomia using basal and pilocarpine SSF is simple to perform, acceptable to patients and needs no special equipment." | 5.10 | Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjögren's syndrome. Correlation with clinical, immunological and histological features. ( Caballero, O; Cervera, R; Ena, J; Font, J; García-Carrasco, M; Ingelmo, M; Pascual, E; Ramos-Casals, M; Rosas, J; Verdu, J, 2002) |
| "This review discusses the randomized trials available on the efficacy and tolerability of oral pilocarpine for the treatment of xerostomia." | 4.84 | Systemic pilocarpine for treatment of xerostomia. ( Berk, L, 2008) |
| " From studies published 2002 to 2005, 15 were identified as high-quality studies and were used to support management recommendations: pilocarpine and cevimeline are recommended for treating hyposalivation and xerostomia in primary and secondary Sjögren's syndrome (SS)." | 4.84 | Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations. ( Brennan, MT; Carrozzo, M; Daniels, T; Fox, PC; Fujibayashi, T; Gandera, B; Jonsson, R; Lockhart, PB; Navazesh, M; Rhodus, NL; Schiødt, M; Sollecito, TP; von Bültzingslöwen, I; Wray, D, 2007) |
| "To analyze the role of oral pilocarpine in the treatment of xerostomia of Sjogren's syndrome (SS)." | 4.80 | The use of oral pilocarpine in xerostomia and Sjögren's syndrome. ( Nusair, S; Rubinow, A, 1999) |
| "Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS." | 3.91 | The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study. ( Chen, TH; Chen, YC; Hsu, CY; Hung, KC; Ko, CH; Lin, CY; Lin, MS; Lin, YS, 2019) |
| "Pilocarpine therapy is useful to improve xerostomia and xerophthalmia in SS patients with moderate and severe glandular involvement." | 3.72 | [Usefulness of oral pilocarpin therapy in the treatment of xerostomia and xerophthalmia in patients with primary Sjögren's syndrome]. ( Bosch, JA; Fonollosa, V; Selva, A; Simeón, CP; Solans, R; Vilardell, M, 2004) |
| "To determine the prognostic value of a test using pilocarpine chloride to identify those patients with xerostomia who may achieve a long-term increase in SFR in response to acupuncture." | 3.70 | Prognostic value of the pilocarpine test to identify patients who may obtain long-term relief from xerostomia by acupuncture treatment. ( Blom, M; Kopp, S; Lundeberg, T, 1999) |
| " Identically appearing placebo solution with the same dosing schedule and duration was used for the control subjects." | 2.67 | Effects of pilocarpine on salivary flow in patients with Sjögren's syndrome. ( Rhodus, NL; Schuh, MJ, 1991) |
| "We undermitted the patient the dental treatment of Sjogren's syndrome." | 2.47 | Scleroderma and CREST syndrome: a case report in dentistry. ( Baldoni, M; Bussolati, A; Lauritano, D; Leonida, A, 2011) |
| "Significant proportion of patients with dry eye has underlying SS, a progressive autoimmune condition." | 2.47 | Treatment of Sjögren's syndrome-associated dry eye an evidence-based review. ( Adyanthaya, RS; Akpek, EK; Baer, AN; Lindsley, KB; McDonnell, PJ; Swamy, R, 2011) |
| "Xerostomia is a common symptom in the elderly population." | 2.43 | Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management. ( Al-Hashimi, I, 2005) |
| " SjS is a relatively rare immune-related adverse event that might sometimes be overlooked." | 1.56 | Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer. ( Furuta, Y; Higashi, T; Miyamoto, H; Nagaoka, K; Naito, H; Nakayama, H; Naoe, H; Tanaka, M; Yoshida, R, 2020) |
| " However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group." | 1.36 | Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren's syndrome. ( Kohno, Y; Kuwada, N; Nonaka, Y; Saito, K; Shimojo, N; Takei, S; Tomiita, M, 2010) |
| "Treatment with pilocarpine hydrochloride tablets may improve saliva secretion in patients taking xerogenic medications and/or suffering from metabolic sialosis expanding the beneficial potential of this sialogogue." | 1.34 | Pilocarpine treatment in a mixed cohort of xerostomic patients. ( Aframian, DJ; Helcer, M; Livni, D; Markitziu, A; Nadler, C; Robinson, SD, 2007) |
| "Oral pilocarpine induced an increase in goblet cells number and an amelioration of conjunctival epithelium not dependent on tear secretion." | 1.33 | Conjunctival epithelium improvement after systemic pilocarpine in patients with Sjogren's syndrome. ( Aragona, P; Di Pietro, R; Mobrici, M; Spinella, R, 2006) |
| "Pilocarpine has been used as an ophthalmologic agent for decades; however, toxicity rarely has been reported in the medical literature." | 1.32 | Pilocarpine toxicity and the treatment of xerostomia. ( Greenberg, MI; Hendrickson, RG; Morocco, AP, 2004) |
| "Pilocarpine HCl has been shown to stimulate parotid and submandibular gland salivary flow." | 1.30 | Oral pilocarpine HCl stimulates labial (minor) salivary gland flow in patients with Sjögren's syndrome. ( Rhodus, NL, 1997) |
| " The dose-response curves for SNI-2011 were approximately parallel to curves for pilocarpine but the potency of SNI-2011 was about 25-fold lower than that of pilocarpine." | 1.29 | Sialogogic activities of SNI-2011 compared with those of pilocarpine and McN-A-343 in rat salivary glands: identification of a potential therapeutic agent for treatment of Sjörgen's syndrome. ( Iwabuchi, Y; Masuhara, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (15.00) | 18.7374 |
| 1990's | 17 (21.25) | 18.2507 |
| 2000's | 31 (38.75) | 29.6817 |
| 2010's | 19 (23.75) | 24.3611 |
| 2020's | 1 (1.25) | 2.80 |
| Authors | Studies |
|---|---|
| Hsu, CY | 1 |
| Hung, KC | 1 |
| Lin, MS | 1 |
| Ko, CH | 1 |
| Lin, YS | 1 |
| Chen, TH | 1 |
| Lin, CY | 1 |
| Chen, YC | 1 |
| Higashi, T | 1 |
| Miyamoto, H | 1 |
| Yoshida, R | 1 |
| Furuta, Y | 1 |
| Nagaoka, K | 1 |
| Naoe, H | 1 |
| Naito, H | 1 |
| Nakayama, H | 1 |
| Tanaka, M | 1 |
| Kuklinski, E | 1 |
| Asbell, PA | 1 |
| Cifuentes, M | 1 |
| Del Barrio-Díaz, P | 1 |
| Vera-Kellet, C | 1 |
| Kweon, SM | 1 |
| Koh, JH | 1 |
| Lee, HN | 1 |
| Kim, E | 1 |
| So, MW | 1 |
| Shin, HJ | 1 |
| Young Choi, H | 1 |
| Lee, SG | 1 |
| Minagi, HO | 1 |
| Ikai, K | 1 |
| Araie, T | 1 |
| Sakai, M | 1 |
| Sakai, T | 1 |
| Al Hamad, A | 1 |
| Lodi, G | 1 |
| Porter, S | 1 |
| Fedele, S | 1 |
| Mercadante, V | 1 |
| Alvarado-Franco, NL | 1 |
| Gonzalez-Marques, C | 1 |
| Olguín-Ramírez, LA | 1 |
| Garza-Alpirez, A | 1 |
| Femat-Roldan, G | 1 |
| Martinez-Ramirez, D | 1 |
| Garlapati, K | 1 |
| Kammari, A | 1 |
| Badam, RK | 1 |
| B E, S | 1 |
| Boringi, M | 1 |
| Soni, P | 1 |
| Ju, UH | 1 |
| Liu, FC | 1 |
| Lin, CS | 1 |
| Huang, WY | 1 |
| Lin, TY | 1 |
| Shen, CH | 1 |
| Chou, YC | 1 |
| Lin, CL | 1 |
| Lin, KT | 1 |
| Kao, CH | 1 |
| Chen, CH | 1 |
| Yang, TY | 1 |
| López-López, J | 1 |
| Jané Salas, E | 1 |
| Chimenos Küstner, E | 1 |
| Gresz, V | 1 |
| Horvath, A | 1 |
| Gera, I | 1 |
| Nielsen, S | 1 |
| Zelles, T | 1 |
| Reina, S | 2 |
| Rodríguez, M | 1 |
| Stranieri, G | 1 |
| Borda, E | 2 |
| Takagi, Y | 1 |
| Sumi, M | 1 |
| Nakamura, H | 1 |
| Sato, S | 1 |
| Kawakami, A | 1 |
| Nakamura, T | 1 |
| Jorkjend, L | 1 |
| Bergenholtz, A | 1 |
| Johansson, AK | 1 |
| Johansson, A | 1 |
| Berk, L | 1 |
| Vosters, JL | 1 |
| Landek-Salgado, MA | 1 |
| Yin, H | 1 |
| Swaim, WD | 1 |
| Kimura, H | 1 |
| Tak, PP | 1 |
| Caturegli, P | 1 |
| Chiorini, JA | 1 |
| Passafaro, D | 1 |
| Sterin-Borda, L | 1 |
| Tomiita, M | 1 |
| Takei, S | 1 |
| Kuwada, N | 1 |
| Nonaka, Y | 1 |
| Saito, K | 1 |
| Shimojo, N | 1 |
| Kohno, Y | 1 |
| Spinato, S | 1 |
| Soardi, CM | 1 |
| Zane, AM | 1 |
| Akpek, EK | 1 |
| Lindsley, KB | 1 |
| Adyanthaya, RS | 1 |
| Swamy, R | 1 |
| Baer, AN | 1 |
| McDonnell, PJ | 1 |
| Lauritano, D | 1 |
| Bussolati, A | 1 |
| Baldoni, M | 1 |
| Leonida, A | 1 |
| Ibrahim, OM | 1 |
| Dogru, M | 1 |
| Kawashima, S | 1 |
| Wakamatsu, TH | 1 |
| Tsubota, K | 1 |
| Fujishima, H | 1 |
| Brennan, MT | 2 |
| Shariff, G | 1 |
| Lockhart, PB | 2 |
| Fox, PC | 3 |
| Drøsdal, HH | 1 |
| Zoukhri, D | 2 |
| Kublin, CL | 2 |
| DEHAAS, EB | 1 |
| Tsifetaki, N | 1 |
| Kitsos, G | 1 |
| Paschides, CA | 1 |
| Alamanos, Y | 1 |
| Eftaxias, V | 1 |
| Voulgari, PV | 1 |
| Psilas, K | 1 |
| Drosos, AA | 1 |
| Solans, R | 1 |
| Bosch, JA | 1 |
| Selva, A | 1 |
| Simeón, CP | 1 |
| Fonollosa, V | 1 |
| Vilardell, M | 1 |
| Hendrickson, RG | 1 |
| Morocco, AP | 1 |
| Greenberg, MI | 1 |
| Baudouin, C | 1 |
| Pisella, PJ | 1 |
| Brignole, F | 1 |
| Li, J | 1 |
| Ha, YM | 1 |
| Kü, NY | 1 |
| Choi, SY | 1 |
| Lee, SJ | 1 |
| Oh, SB | 1 |
| Kim, JS | 1 |
| Lee, JH | 1 |
| Lee, EB | 1 |
| Song, YW | 1 |
| Park, K | 1 |
| Atkinson, JC | 2 |
| Grisius, M | 1 |
| Massey, W | 1 |
| Al-Hashimi, I | 3 |
| Aragona, P | 1 |
| Di Pietro, R | 1 |
| Spinella, R | 1 |
| Mobrici, M | 1 |
| Cha, S | 1 |
| Singson, E | 1 |
| Cornelius, J | 1 |
| Yagna, JP | 1 |
| Knot, HJ | 1 |
| Peck, AB | 1 |
| Brito-Zerón, P | 1 |
| Ramos-Casals, M | 2 |
| Nardi, N | 1 |
| Font, J | 2 |
| Wu, CH | 1 |
| Hsieh, SC | 1 |
| Lee, KL | 1 |
| Li, KJ | 1 |
| Lu, MC | 1 |
| Yu, CL | 1 |
| Naumann, UK | 1 |
| Käser, L | 1 |
| Vetter, W | 1 |
| Gause, A | 1 |
| Aframian, DJ | 1 |
| Helcer, M | 1 |
| Livni, D | 1 |
| Robinson, SD | 1 |
| Markitziu, A | 1 |
| Nadler, C | 1 |
| Gibson, J | 1 |
| Halliday, JA | 1 |
| Ewert, K | 1 |
| Robertson, S | 1 |
| von Bültzingslöwen, I | 1 |
| Sollecito, TP | 1 |
| Daniels, T | 1 |
| Jonsson, R | 1 |
| Wray, D | 1 |
| Carrozzo, M | 1 |
| Gandera, B | 1 |
| Fujibayashi, T | 1 |
| Navazesh, M | 1 |
| Rhodus, NL | 5 |
| Schiødt, M | 1 |
| Soyfoo, MS | 1 |
| De Vriese, C | 1 |
| Debaix, H | 1 |
| Martin-Martinez, MD | 1 |
| Mathieu, C | 1 |
| Devuyst, O | 1 |
| Steinfeld, SD | 1 |
| Delporte, C | 1 |
| Setälä, K | 2 |
| Tarkkanen, J | 1 |
| Tarkiainen, E | 1 |
| Nyyssönen, O | 1 |
| Iwabuchi, Y | 1 |
| Masuhara, T | 1 |
| Takaya, M | 1 |
| Ichikawa, Y | 1 |
| Yamada, C | 1 |
| Hoshina, Y | 1 |
| Horiki, T | 1 |
| Uchiyama, M | 1 |
| LeVeque, F | 1 |
| Papas, AS | 1 |
| Fernandez, MM | 1 |
| Castano, RA | 1 |
| Gallagher, SC | 3 |
| Trivedi, M | 2 |
| Shrotriya, RC | 2 |
| Nelson, JD | 1 |
| Friedlaender, M | 1 |
| Yeatts, RP | 1 |
| Yee, R | 1 |
| McDermott, M | 1 |
| Orlin, S | 1 |
| Vivino, FB | 2 |
| Khan, Z | 1 |
| LeVeque, FG | 1 |
| Salisbury, PL | 1 |
| Tran-Johnson, TK | 1 |
| Muscoplat, CC | 1 |
| Goldlust, B | 1 |
| Liljemark, W | 1 |
| Bloomquist, C | 1 |
| Bereuter, J | 2 |
| Blom, M | 1 |
| Kopp, S | 1 |
| Lundeberg, T | 1 |
| Rhodus, N | 1 |
| Dahmer, L | 1 |
| Lindemann, K | 1 |
| Rudney, J | 1 |
| Mathur, A | 1 |
| Nusair, S | 1 |
| Rubinow, A | 1 |
| Anaya, JM | 1 |
| Talal, N | 1 |
| Bell, M | 1 |
| Askari, A | 1 |
| Bookman, A | 1 |
| Frydrych, S | 1 |
| Lamont, J | 1 |
| McComb, J | 1 |
| Muscoplat, C | 1 |
| Slomovic, A | 1 |
| Fox, RI | 2 |
| Michelson, P | 1 |
| Canapp, SO | 1 |
| Cohn, LA | 1 |
| Maggs, DJ | 1 |
| Miller, MA | 1 |
| Kerl, ME | 1 |
| O'Brien, DP | 1 |
| Taylor, SE | 1 |
| Baum, BJ | 1 |
| Konttinen, Y | 1 |
| Fisher, A | 1 |
| Rosas, J | 1 |
| Ena, J | 1 |
| García-Carrasco, M | 1 |
| Verdu, J | 1 |
| Cervera, R | 1 |
| Caballero, O | 1 |
| Ingelmo, M | 1 |
| Pascual, E | 1 |
| Gelinsky, P | 1 |
| Havlik, E | 1 |
| Scherak, O | 1 |
| Bergmann, H | 1 |
| Kolarz, G | 1 |
| Ingrand, J | 1 |
| Danchot, J | 1 |
| Menkes, CJ | 1 |
| Delbarre, F | 1 |
| Roucayrol, JC | 1 |
| Mandel, ID | 1 |
| Schuh, MJ | 1 |
| Rees, JL | 1 |
| Pal, B | 1 |
| Watts, KD | 1 |
| Arrago, JP | 1 |
| Rain, JD | 1 |
| Brocheriou, C | 1 |
| Rocher, F | 1 |
| Szabó, G | 1 |
| Fourestier, J | 1 |
| Gacon, J | 1 |
| Brisou, B | 1 |
| Le Stir, A | 1 |
| Morcelet, JL | 1 |
| Kanetani, S | 1 |
| Kameda, H | 1 |
| Oya, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome[NCT04470479] | Phase 3 | 32 participants (Actual) | Interventional | 2005-03-01 | Completed | ||
| Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.[NCT05585476] | 98 participants (Anticipated) | Interventional | 2022-12-31 | Not yet recruiting | |||
| Xerostomy Treatment in Patients With Sjogren's Syndrome in Chile :A Double Blind Control Trial Comparing Orally Pilocarpine Drops and Artificial Saliva[NCT00438048] | Phase 4 | 76 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Impact of a Home-based Exercise Program on Prognostic Biomarkers in Men With Prostate Cancer[NCT03397030] | 27 participants (Actual) | Interventional | 2017-01-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for pilocarpine and Sjogren's Syndrome
| Article | Year |
|---|---|
Sjogren's syndrome from the perspective of ophthalmology.
Topics: Administration, Ophthalmic; Cyclosporine; Dry Eye Syndromes; Fatty Acids, Omega-3; Glucocorticoids; | 2017 |
Interventions for dry mouth and hyposalivation in Sjögren's syndrome: A systematic review and meta-analysis.
Topics: Humans; Muscarinic Agonists; Pilocarpine; Quality of Life; Randomized Controlled Trials as Topic; Sa | 2019 |
Meta-analysis on pharmacological therapies in the management of xerostomia in patients with Sjogren's syndrome.
Topics: Female; Humans; Interferon-alpha; Male; Pilocarpine; Quinuclidines; Saliva; Sjogren's Syndrome; Thio | 2019 |
[Prognosis and treatment of dry mouth. Systematic review].
Topics: Cholinergic Antagonists; Clinical Trials as Topic; Dental Caries; Disease Susceptibility; Double-Bli | 2014 |
Systemic pilocarpine for treatment of xerostomia.
Topics: Administration, Oral; Head and Neck Neoplasms; Humans; Muscarinic Agonists; Pilocarpine; Radiation I | 2008 |
Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.
Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents; Dry Eye Syndromes; Evidence | 2011 |
Scleroderma and CREST syndrome: a case report in dentistry.
Topics: Aged; Combined Modality Therapy; CREST Syndrome; Deglutition Disorders; Dental Caries; Dentures; Dis | 2011 |
Treatment of xerostomia: a systematic review of therapeutic trials.
Topics: Acupuncture Therapy; Bias; Humans; Muscarinic Agonists; Pilocarpine; Radiotherapy; Randomized Contro | 2002 |
[Current treatments of xerophthalmia in Sjögren's syndrome].
Topics: Administration, Topical; Anti-Infective Agents, Local; Cyclosporine; Gels; Humans; Immunosuppressive | 2004 |
Salivary hypofunction and xerostomia: diagnosis and treatment.
Topics: Aged; Aged, 80 and over; Cariostatic Agents; Fluorides; Humans; Pilocarpine; Polypharmacy; Quinuclid | 2005 |
Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management.
Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Humans; Muscarinic Agonists; Pilocarpine; Quinucli | 2005 |
[Sjogren's syndrome].
Topics: Age Factors; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Ophtha | 2006 |
Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Diabetes Complicat | 2007 |
The use of oral pilocarpine in xerostomia and Sjögren's syndrome.
Topics: Administration, Oral; Head and Neck Neoplasms; Humans; Muscarinic Agonists; Pilocarpine; Radiation I | 1999 |
Sjögren's syndrome comes of age.
Topics: Apoptosis; Humans; Lymphocytosis; Muscarinic Agonists; Pilocarpine; Quinuclidines; Receptors, Muscar | 1999 |
Sjögren's syndrome: a critical review of clinical management.
Topics: Combined Modality Therapy; Controlled Clinical Trials as Topic; Female; Humans; Male; Parasympathomi | 1999 |
Sjögren's syndrome.
Topics: Adult; Female; Humans; Male; Pilocarpine; Saliva; Saliva, Artificial; Salivary Glands, Minor; Sialog | 1999 |
Approaches to the treatment of Sjögren's syndrome.
Topics: Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2000 |
The treatment of Sjögren's syndrome patients with pilocarpine-tablets.
Topics: Administration, Oral; Clinical Trials as Topic; Female; Humans; Male; Muscarinic Agonists; Pilocarpi | 2001 |
Use of muscarinic agonists in the treatment of Sjögren's syndrome.
Topics: Humans; Muscarinic Agonists; Neuroimmunomodulation; Neurosecretory Systems; Pilocarpine; Quinuclidin | 2001 |
9 trials available for pilocarpine and Sjogren's Syndrome
| Article | Year |
|---|---|
Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial.
Topics: Administration, Oral; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarini | 2018 |
Oral pilocarpine for the treatment of ocular symptoms in patients with Sjögren's syndrome: a randomised 12 week controlled study.
Topics: Administration, Oral; Female; Humans; Middle Aged; Miotics; Ophthalmic Solutions; Pilocarpine; Sjogr | 2003 |
Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren's syndrome in Taiwan--a double-blind, placebo-controlled trial.
Topics: Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Pilocarpine; R | 2006 |
[Treatment with pilocarpine hydrochloride for sicca symptoms in Sjögren's syndrome].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Middle Aged; Parasympathomimetics; Pilocarpine; S | 1997 |
Oral pilocarpine for symptomatic relief of dry mouth and dry eyes in patients with Sjögrens syndrome.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Double-Blind Method; Dry Eye Syndromes; Electr | 1998 |
Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sjögren's syndrome. The MGI PHARMA Sjögren's Syndrome Study Group.
Topics: Administration, Oral; Double-Blind Method; Humans; Keratoconjunctivitis Sicca; Miotics; Pilocarpine; | 1998 |
Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group.
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Lacrimal Apparatus; Male; Middle Aged; Pa | 1999 |
Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjögren's syndrome. Correlation with clinical, immunological and histological features.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anethole Trithione; Cholinergic Agents; Female; Humans; | 2002 |
Effects of pilocarpine on salivary flow in patients with Sjögren's syndrome.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Parotid Gland; Patient Satisfaction; Pilocarpine; Sa | 1991 |
51 other studies available for pilocarpine and Sjogren's Syndrome
| Article | Year |
|---|---|
The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study.
Topics: Adult; Candidiasis; Dental Caries; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Outcome A | 2019 |
Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer.
Topics: Antineoplastic Agents; Female; Humans; Nivolumab; Pilocarpine; Prednisolone; Salivary Glands; Sjogre | 2020 |
Primary Sjogren syndrome diagnosed simultaneously with localized amyloidosis of the lacrimal gland: A case report.
Topics: Amyloidosis; Antirheumatic Agents; Biopsy; Female; Humans; Hydroxychloroquine; Lacrimal Apparatus; M | 2018 |
Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.
Topics: Aged; Animals; Female; Humans; Male; Mice, Inbred ICR; Middle Aged; Muscarinic Agonists; Pilocarpine | 2018 |
Athetoid Movements as Initial Manifestation of Primary Sjögren Syndrome.
Topics: Aged; Amines; Anticonvulsants; Athetosis; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami | 2018 |
Risk of Parkinson disease in Sjögren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Comorbidity; Female; Humans; Hydroxychl | 2019 |
Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sjögren's syndrome.
Topics: Adult; Aged; Aquaporin 5; Biopsy; Case-Control Studies; Female; Humans; Microscopy, Immunoelectron; | 2015 |
Action of anti-M₃muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland.
Topics: Acetylcholine; Adult; Amino Acid Sequence; Animals; Antioxidants; Autoantibodies; Catalase; Cyclooxy | 2015 |
Salivary gland ultrasonography as a primary imaging tool for predicting efficacy of xerostomia treatment in patients with Sjögren's syndrome.
Topics: Administration, Oral; Aged; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glucocortic | 2016 |
Effect of Pilocarpine on impaired salivary secretion in patients with Sjögren's syndrome.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Muscarinic | 2008 |
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
Topics: Animals; Antibodies, Antinuclear; Biomarkers; Body Weight; Cell Enlargement; Cell Proliferation; Cho | 2009 |
Cholinergic autoantibodies from primary Sjögren's syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP.
Topics: Adult; Animals; Autoantibodies; Cells, Cultured; Cyclic AMP; Dinoprostone; Female; Humans; Immunoglo | 2010 |
Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren's syndrome.
Topics: Administration, Oral; Adolescent; Child; Female; Humans; Male; Muscarinic Agonists; Pilocarpine; Pil | 2010 |
A mandibular implant-supported fixed complete dental prosthesis in a patient with Sjogren syndrome: case report.
Topics: Cholinergic Agents; Dental Care for Chronically Ill; Dental Implantation, Endosseous; Dental Prosthe | 2010 |
Visante optical coherence tomography and tear function test evaluation of cholinergic treatment response in patients with sjögren syndrome.
Topics: Administration, Oral; Aged; Female; Fluorescent Dyes; Fluorophotometry; Humans; Muscarinic Agonists; | 2013 |
[Pilocarpus in Sjogren's syndrome].
Topics: Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Sjogren's Syndrome | 2003 |
Impaired neurotransmission in lacrimal and salivary glands of a murine model of Sjögren's syndrome.
Topics: Acetylcholine; Animals; Female; Injections, Intraperitoneal; Isoproterenol; Lacrimal Apparatus; Male | 2002 |
THE RESPONSE OF THE LACRIMAL GLAND TO PARASYMPATHICOMIMETICS IN KERATOCONJUNCTIVITIS SICCA.
Topics: Drug Therapy; Dry Eye Syndromes; Humans; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Methacholin | 1964 |
[Usefulness of oral pilocarpin therapy in the treatment of xerostomia and xerophthalmia in patients with primary Sjögren's syndrome].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Male; Middle Aged; Miotics; Pilocarpine; Sjogren' | 2004 |
Pilocarpine toxicity and the treatment of xerostomia.
Topics: Administration, Oral; Drug Overdose; Female; Humans; Middle Aged; Muscarinic Agonists; Pilocarpine; | 2004 |
Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome.
Topics: Adult; Aquaporin 5; Aquaporins; Autoantibodies; Calcium; Calcium Channels; Carbachol; Cell Line, Tum | 2004 |
Conjunctival epithelium improvement after systemic pilocarpine in patients with Sjogren's syndrome.
Topics: Administration, Oral; Adult; Aged; Cell Count; Conjunctiva; Epithelium; Female; Goblet Cells; Humans | 2006 |
Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren's syndrome-associated autoantibodies.
Topics: Animals; Antibodies, Blocking; Autoantibodies; Carbachol; Disease Models, Animal; Dose-Response Rela | 2006 |
[Results of the treatment with oral pilocarpine in 100 patients with primary Sjögrens syndrome].
Topics: Administration, Oral; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Salivary | 2006 |
[Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].
Topics: Bromhexine; Cyclosporine; Dry Eye Syndromes; Electric Stimulation Therapy; Expectorants; Humans; Mus | 2007 |
Pilocarpine treatment in a mixed cohort of xerostomic patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Body Temperature; Cohort Studies; Dizziness; Drug-Re | 2007 |
A controlled release pilocarpine buccal insert in the treatment of Sjögren's syndrome.
Topics: Administration, Buccal; Aged; Delayed-Action Preparations; Drug Implants; Female; Humans; Male; Midd | 2007 |
Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy.
Topics: Animals; Aquaporin 5; Female; Gene Expression; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Parotid | 2007 |
Pilocarpine in salivary gland and thyroid photoscanning.
Topics: Humans; Middle Aged; Pilocarpine; Radionuclide Imaging; Sialography; Sjogren's Syndrome; Technetium; | 1967 |
Sialogogic activities of SNI-2011 compared with those of pilocarpine and McN-A-343 in rat salivary glands: identification of a potential therapeutic agent for treatment of Sjörgen's syndrome.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adrenergic Antagonists; Animal | 1994 |
Re: Researchers make slow headway in managing dry mouth.
Topics: Administration, Oral; Head and Neck Neoplasms; Humans; Lymphoma; Parasympathomimetics; Pilocarpine; | 1997 |
Oral pilocarpine HCl stimulates labial (minor) salivary gland flow in patients with Sjögren's syndrome.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Parasympathomimetics; Pilocarpi | 1997 |
ACR presentations support Salagen tablets as a safe and effective treatment for the dry mouth symptoms caused by Sjögren's syndrome.
Topics: Humans; Parasympathomimetics; Pilocarpine; Sjogren's Syndrome; Xerostomia | 1999 |
Candida albicans levels in patients with Sjögren's syndrome before and after long-term use of pilocarpine hydrochloride: a pilot study.
Topics: Adult; Candida albicans; Colony Count, Microbial; Female; Humans; Middle Aged; Parasympathomimetics; | 1998 |
Prognostic value of the pilocarpine test to identify patients who may obtain long-term relief from xerostomia by acupuncture treatment.
Topics: Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Parasympatho | 1999 |
s-IgA and cytokine levels in whole saliva of Sjögren's syndrome patients before and after oral pilocarpine hydrochloride administration: a pilot study.
Topics: Administration, Oral; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immun | 1998 |
Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (Sjögren's-like syndrome) in a cat.
Topics: Animals; Anti-Bacterial Agents; Atropine; Biopsy; Cat Diseases; Cats; Clindamycin; Cornea; Deglutiti | 2001 |
Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
Topics: Acetylcholine; Animals; Choline; Disease Models, Animal; Female; Injections, Intraperitoneal; Isopro | 2001 |
A new medication for treatment of dry mouth in Sjögren's syndrome.
Topics: Contraindications; Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Receptors, Muscarinic; S | 2001 |
Salivary enhancement: current status and future therapies.
Topics: Animals; Aquaporin 1; Aquaporins; Blood Group Antigens; Cholinergic Agents; Cranial Irradiation; Den | 2001 |
[Measurement by means of 99mTc-pertechnetate of the function of salivary glands before and after stimulation with pilocarpine in cases of sicca-syndrome of the parotidic glands (author's transl)].
Topics: Adult; Aged; Carbachol; Female; Humans; Hypopharynx; Male; Middle Aged; Parotid Gland; Pharyngeal Ne | 1979 |
[Technetium uptake in the parotid gland. Value of functional parameters in Sjögren's syndrome].
Topics: Humans; Parotid Gland; Pilocarpine; Radionuclide Imaging; Sjogren's Syndrome; Subtraction Technique; | 1976 |
[Quantitative functional exploration of the salivary glands. Measurement of salivary elimination of technetium 99].
Topics: Arthritis, Rheumatoid; Atropine; Lupus Erythematosus, Systemic; Parotitis; Pilocarpine; Radionuclide | 1975 |
Effects of pilocarpine on salivary flow in patients with Sjogren's syndrome.
Topics: Humans; Journalism, Dental; Pilocarpine; Salivation; Secretory Rate; Sjogren's Syndrome | 1992 |
Stimulated eccrine gland function in primary Sjögren's syndrome.
Topics: Adult; Aged; Eccrine Glands; Female; Humans; Middle Aged; Pilocarpine; Sjogren's Syndrome; Sweating | 1989 |
'A double-blind cross-over trial of a mucin-containing artificial saliva'.
Topics: Double-Blind Method; Humans; Mouthwashes; Mucins; Pilocarpine; Saliva, Artificial; Sjogren's Syndrom | 1989 |
Scintigraphy of the salivary glands in Sjögen's syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Male; Middle Aged; Parotid Gland; | 1987 |
[Treatment of xerostomia with pilocarpine. Based on l5 years' experience and treatment of 500 patients].
Topics: Humans; Pilocarpine; Salivary Gland Diseases; Sjogren's Syndrome; Xerostomia | 1985 |
[Radioisotope scanning of salivary glands in dry mouth].
Topics: Adult; Aged; Atropine; Biopsy; Female; Humans; Injections, Intramuscular; Injections, Intravenous; M | 1972 |
[Sjogren's syndrome: report of a case].
Topics: Dentistry; Pilocarpine; Sjogren's Syndrome | 1966 |
An attempt at quantitative analysis of surface scannograms.
Topics: Humans; Iodine Radioisotopes; Molybdenum; Photography; Pilocarpine; Radioisotopes; Radionuclide Imag | 1968 |