pilocarpine has been researched along with Seizures in 772 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 8.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| "High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration." | 8.77 | Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Turski, L; Turski, WA, 1989) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 8.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 8.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " The aim of this study was to investigate the mechanism of action of ASP and GP through the experimental model of pilocarpine-induced seizures." | 8.31 | Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice. ( da SilvaTorres, IL; de Oliveira, JDM; Medeiros, HR; Pereira, P; Pflüger, P; Picada, JN; Uczay, M; Vendruscolo, MH; von Poser, G, 2023) |
| "The objective of this work was to evaluate the antiseizure effect of the antioxidants allopurinol (ALL) and ellagic acid during status epilepticus induced by pilocarpine (PILO)." | 8.31 | Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus. ( Martínez-Gallegos, S; Medina-Ceja, L; Pardo-Peña, K; Sánchez-Lira, A, 2023) |
| " In this study, we investigated the anti-inflammatory action of eugenol in an experimental epilepsy model of pilocarpine-induced status epilepticus (SE)." | 8.31 | Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, CH; Kim, WJ; Park, S; Zhu, J, 2023) |
| "The present study was undertaken to investigate the efficacy of a characterized hydroalcoholic extract (NJET) of Nardostachys jatamansi in the lithium-pilocarpine rat model of spontaneous recurrent seizures (SRS) and associated cardiac irregularities." | 8.31 | Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. ( Patial, V; Rahmatkar, SN; Rana, AK; Sharma, S; Singh, D, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 8.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 8.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| "Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase." | 8.12 | Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. ( Amado, D; Amorim, RP; Cossa, AC; da Silva, JC; Dal Pai, J; Predebon, G; Sanabria, V; Trindade-Filho, E, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 8.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 8.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 8.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 8.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Initial seizures observed in young rats during the 60 min after administration of pilocarpine (Pilo) were delayed and attenuated by pretreatment with a non-convulsive dose of methionine sulfoximine (MSO)." | 8.02 | Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose. ( Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP, 2021) |
| " We examined the levels of α-actn-2 expression within the dentate gyrus (DG) during the development of chronic limbic seizures (epileptogenesis) induced by pilocarpine in rats." | 8.02 | The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures. ( Bole, A; Esclapez, M; Ferhat, L; Khrestchatisky, M; Sbai, O; Soussi, R, 2021) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 7.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| " Thereafter, pilocarpine was administered, and significant differences in susceptibility to seizures were detected depending on the degree of brain dysplasia." | 7.96 | Changes of EEG spectra in rat brains with different patterns of dysplasia in response to pilocarpine-induced seizures. ( Gzieło, K; Janeczko, K; Kiełbinski, M; Setkowicz, Z; Węglarz, W, 2020) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 7.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 7.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| " Status epilepticus (SE) was induced via systemic injection of pilocarpine." | 7.91 | Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment. ( Huang, H; Huang, M; Lin, R; Lin, W; Liu, C; Ma, Y; Wen, Y, 2019) |
| " Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy." | 7.91 | Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms. ( Chaves-Filho, A; de Carvalho Lima, CN; de Carvalho, MAJ; de França Fonteles, MM; de Lima, KA; de Souza, AG; de Souza, DAA; de Souza, FCF; Feitosa, ML; Macedo, DS; Rios Vasconcelos, ER; Souza Oliveira, JV, 2019) |
| " We examined the impact of early minor activation of TLR4 and TLR2 on the severity of seizure in the pilocarpine rat model of temporal lobe epilepsy (TLE)." | 7.91 | Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. ( Daftari, M; Hosseinzadeh, M; Khodagholi, F; Motamedi, F; Naderi, N; Pourbadie, HG, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 7.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 7.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 7.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "The present results indicate that tangeretin exerted potent neuroprotective effects against pilocarpine-induced seizures via the activation of PI3K/Akt signaling and the regulation of MMPs." | 7.85 | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. ( Cao, YL; Guo, XQ; Hao, F; Liu, XW; Wang, ML; Yan, ZR, 2017) |
| " Herein, we confirmed that pilocarpine application promptly (<30 min) induces status epilepticus (SE) as revealed by changes in rat electrocorticogram particularly in fast-beta range (21-30 Hz)." | 7.83 | Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. ( Britto, LR; Damico, MV; de Sousa, E; Higa, GS; Kihara, AH; Kinjo, ER; Morya, E; Santos, BA; Valle, AC; Walter, LT, 2016) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 7.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 7.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " We investigated the effects of ketogenic diets (KDs) containing coconut oil, triheptanoin, or soybean oil on pilocarpine-induced status epilepticus (SE) in rats." | 7.81 | Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. ( Barros, EM; Bueno, NB; Cabral-Junior, CR; da Rocha Ataide, T; Domingos, BR; Ferreira, RC; Galvão, JA; Gama, IR; Melo, IT; Oliveira, SL; Pereira, WS; Trindade-Filho, EM, 2015) |
| "Nimodipine has been shown to have an inhibitory action on seizures and brain damage in rodents." | 7.81 | Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice. ( Cavalcanti, IM; Freitas, RM; Moreno, LC; Rolim, HM; Santos-Magalhães, NS; Satyal, P, 2015) |
| "A common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine, yet the mechanisms underlying the induction of pilocarpine-induced seizures (PISs) remain unclear." | 7.81 | Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. ( DeCan, E; Deisseroth, K; Lawrence, JJ; Marceau, E; Stoll, K; Yi, F, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 7.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| " In this study, apart from unravelling the effect of des-acyl ghrelin on seizure thresholds and seizure severity in two models of pilocarpine-induced seizures, we mainly attempted to unravel its anticonvulsant mechanism of action." | 7.81 | Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway. ( Coppens, J; Demuyser, T; Portelli, J; Smolders, I, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 7.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 7.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively." | 7.81 | Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. ( Chen, XM; Huang, LF; Liang, JJ; Lu, ZN; Pan, SQ; Xiao, ZM, 2015) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 7.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| " We found that subchronic treatment (4 days) with Nω-nitro-l-arginine reduced the down-regulation of muscarinic receptors induced by pilocarpine and kainic acid in rat fronto-parietal cortex, notwithstanding the dramatic potentiation of seizures induced by both convulsants." | 7.80 | Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex. ( Aloisi, G; Capannolo, M; Ciccarelli, C; Fasciani, I; Fumagalli, F; Maggio, R; Molteni, R; Riva, MA; Rocchi, C; Romeo, S; Zani, BM, 2014) |
| "Status epilepticus (SE) was induced by intraperitoneal injection of 340mg/kg pilocarpine, and terminated by diazepam after 40min." | 7.80 | Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures. ( Groeneweg, L; Kirschstein, T; Köhling, R; Müller, L; Müller, S; Sellmann, T; Tokay, T, 2014) |
| "The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats." | 7.80 | Neuroprotective effects of idebenone against pilocarpine-induced seizures: modulation of antioxidant status, DNA damage and Na(+), K (+)-ATPase activity in rat hippocampus. ( Ahmed, MA, 2014) |
| "Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy." | 7.80 | Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. ( Jiang, K; Kow, RL; Le, JH; Nathanson, NM; Naydenov, AV; Stella, N, 2014) |
| " However, it is still not known whether puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures." | 7.80 | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. ( Lian, Y; Wang, C; Wu, C; Xie, N; Zhang, H; Zhang, Q, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 7.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| " In this study, we examined the role of mdivi-1 in hippocampal neuron death after seizures induced by pilocarpine." | 7.79 | A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. ( Lian, Y; Wang, C; Wu, C; Xie, N; Zhang, H; Zhang, Q, 2013) |
| ") administration of α-MSH altered PTZ- and pilocarpine-induced seizures." | 7.79 | Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures. ( Guerra, GP; Jesse, AC; Lenz, QF; Marafiga, JR; Mello, CF; Oliveira, SM; Santos, AC; Scimonelli, TN; Temp, FR, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 7.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| " However, whether there is a neuroprotective effect of AG in hippocampal neurons of pilocarpine-induced seizures in rats, is still unknown." | 7.79 | Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis. ( Guo, F; Wang, H; Wang, Q; Yang, G; Zhang, R, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "In the present work, synchrotron radiation Fourier-transform infrared (SRFTIR) and Raman microspectroscopies were used to evaluate a possible role of creatine in the pathogenesis and progress of pilocarpine-evoked seizures and seizure-induced neurodegenerative changes in the rat hippocampal tissue." | 7.78 | Synchrotron radiation Fourier-transform infrared and Raman microspectroscopy study showing an increased frequency of creatine inclusions in the rat hippocampal formation following pilocarpine-induced seizures. ( Chwiej, J; Dulinska, J; Dumas, P; Gzielo-Jurek, K; Janeczko, K; Sandt, C; Setkowicz, Z; Uram, L, 2012) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 7.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| "Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE)." | 7.78 | Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. ( Coimbra, Rde C; Fernandes, MJ; Massironi, SG; Mazzacoratti, Mda G; Nehlig, A; Neto, EF; Persike, DS; Silva, IR; Vignoli, T, 2012) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 7.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| " Here we explored the expression of synaptotagmin7 mRNA in the brains of rats with seizures triggered by the glutamatergic agonist kainate (10 mg/kg) or by the muscarinic agonist pilocarpine (30 mg/kg) in LiCl (3 mEq/kg) pre-treated (24 h) rats, in a time-course experiment (30 min-1 day)." | 7.78 | Differential patterns of synaptotagmin7 mRNA expression in rats with kainate- and pilocarpine-induced seizures. ( Glavan, G; See, RE; Živin, M, 2012) |
| " In the present work, we investigated whether pilocarpine-induced status epilepticus (SE) would alter Homer1a and mGluR5 expression in hippocampus." | 7.78 | Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. ( Blanco, MM; Cavarsan, CF; Mello, LE; Morais, RL; Motta, FL; Tescarollo, F; Tesone-Coelho, C, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 7.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE)." | 7.78 | Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. ( Cui, XL; Jiang, W; Li, XW; Ma, L; Wang, Y; Wei, D; Yang, F, 2012) |
| "Status epilepticus (SE), a pro-epileptogenic brain insult in rodent models of temporal lobe epilepsy, is successfully induced by pilocarpine in some, but not all, rats." | 7.78 | Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats. ( Chen, MT; Hung, CP; Lin, YY; Shih, YH; Wang, CH, 2012) |
| "The effect of intraperitoneal administration of curcumin (30, 100, and 300 mg/kg) on pilocarpine-induced seizures in rats was tested." | 7.78 | Anticonvulsive and antioxidant effects of curcumin on pilocarpine-induced seizures in rats. ( DU, P; Fan, W; Li, X; Lin, HJ; Ma, Y; Peng, WF; Tang, HY; Wang, X, 2012) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1β (IL-1β) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures. ( de Freitas, RM; Gomes, KN; Saldanha, GB, 2011) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 7.77 | Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures. ( Chi, Z; Han, Y; Jiang, H; Lin, Y; Wang, S; Xie, N; Xu, J; Xue, Y, 2011) |
| "The effects of ALAC administered per os were evaluated by standard protocols against audiogenic seizures in Genetic Epilepsy Prone Rats (GEPR-9 rats), maximal electroshock (MES)-induced seizures in rats, pilocarpine-induced seizures in mice, spontaneous chronic seizures in mice exposed to pilocarpine-induced status epilepticus (SE), and absence seizures in WAG/Rij rats." | 7.77 | Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. ( Citraro, R; De Fazio, S; De Sarro, G; Mainardi, P; Perucca, E; Raggio, R; Russo, E; Scicchitano, F, 2011) |
| "Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes." | 7.77 | Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures. ( Campêlo, LM; Feitosa, CM; Freitas, RL; Freitas, RM; Saldanha, GB; Santos, PS, 2011) |
| "The present study has been designed to pharmacologically investigate the effect of Montelukast sodium, a leukotriene D(4) receptor antagonist, and 1,2,3,4, tetrahydroisoquinoline, a leukotriene D(4) synthetic pathway inhibitor, on the pathophysiological progression of seizures using mouse models of kindled epilepsy and status epilepticus induced spontaneous recurrent seizures." | 7.77 | Modulation of leukotriene D4 attenuates the development of seizures in mice. ( Rehni, AK; Singh, TG, 2011) |
| " The objective of the present study was to evaluate the neuroprotective effects of alpha-tocopherol in rats against oxidative stress caused by pilocarpine-induced seizures." | 7.77 | Oxidative stress in rat striatum after pilocarpine-induced seizures is diminished by alpha-tocopherol. ( Costa, JP; de Freitas, RM; de Souza, GF; dos Santos, PS; Feng, D; Saldanha, GB; Tomé, Ada R, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 7.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "Pilocarpine (PC), a muscarinic receptor agonist, is used for the induction of experimental models of status epilepticus (SE) for studying the type of seizure-induced brain injury and other neuropathophysiological mechanisms of related disorder." | 7.76 | The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. ( Chang, CN; Chang, SJ; Tsai, HL, 2010) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "Using the epilepsy model obtained by systemic administration of pilocarpine in rats in the present study we investigated the changes caused by seizures on content and species of gangliosides and phospholipids, as well as on cholesterol concentration, glutathione reduced contents, Na(+), K(+)-ATPase activity and lipid peroxidation levels in rat hippocampus." | 7.76 | Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures. ( de Freitas, RM; do Nascimento, KG; Ferreira, PM; Jordán, J, 2010) |
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 7.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "In the present study we investigated the alterations on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in rat striatum and frontal cortex caused by pilocarpine-induced seizures." | 7.76 | Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures. ( Freitas, RL; Freitas, RM; Saldanha, GB; Sales, IM; Souza, GF, 2010) |
| " It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress." | 7.76 | The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Tomé, AR, 2010) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 7.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| "In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine." | 7.76 | Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. ( de Freitas, RM; de Souza, GF; Feitosa, CM; Feng, D; Jordán, J; Santos, IM; Tomé, Ada R, 2010) |
| ")-injected GLP-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat." | 7.76 | Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat. ( Gulec, G; Isbil-Buyukcoskun, N; Kahveci, N, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 7.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| "Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring." | 7.76 | Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Jordán, J, 2010) |
| "To examine the expression of IL-1beta, IL-1ra and IL-1R mRNA in the dentate gyrus of adult rats after lithium-pilocarpine (Li-PILO)-induced seizures." | 7.76 | [Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures]. ( Jiang, W; Li, XW; Wang, Y; Wei, D; Zhang, SJ, 2010) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 7.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| "To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy." | 7.75 | Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. ( Ballester, G; Bonilha, SM; Covolan, L; Ewerton, FI; Fantin Cavarsan, C; Hamani, C; Lozano, AM; Marcolin de Almeida, F; Mello, LE, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 7.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| "It has been suggested that pilocarpine-induced seizures is mediated by increases in oxidative stress." | 7.75 | The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures. ( Freitas, RM, 2009) |
| " However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 7.75 | Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. ( Cao, L; Chi, Z; Lin, Y; Wang, R; Wang, S; Xu, J, 2009) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 7.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 7.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 7.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 7.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection." | 7.75 | Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. ( Arisi, GM; Foresti, ML; Katki, K; Montañez, A; Sanchez, RM; Shapiro, LA, 2009) |
| "Recent evidence suggests that amiloride, a potent and nonselective blocker of acid-sensing ion channels, suppresses generalized seizures induced by maximal electroshock and pentylenetrazole." | 7.74 | Amiloride delays the onset of pilocarpine-induced seizures in rats. ( N'Gouemo, P, 2008) |
| "The present study was designed to examine whether neuroprotective agents, FK506 or cyclosporin A (CsA), applied to rats undergoing pilocarpine-induced seizures can minimize further development of the status epilepticus." | 7.74 | Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures. ( Ciarach, M; Setkowicz, Z, 2007) |
| " Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy." | 7.74 | Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures. ( Aguiar, LM; Almeida, JP; Fonseca, FN; Fonteles, MM; Freitas, RM; Júnior, HV; Nascimento, VS; Oliveira, AA; Sousa, FC; Viana, GS, 2007) |
| ") injection of L-NAME (a nitric oxide synthase inhibitor) or CaEDTA (an extracellular zinc chelator) or the combination of the two could affect the initial phase of pilocarpine induced (2 h) seizures." | 7.74 | The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures. ( Danscher, G; Jensen, MS; Noyan, B, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 7.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats." | 7.74 | Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine. ( Barbosa, CO; Barros, DO; Freitas, RM; Oliveira, AA; Silva, RF; Xavier, SM, 2007) |
| "The anticonvulsant effects of AN stimulation against pilocarpine-induced seizures were mainly determined by the current and not the frequency of stimulation." | 7.74 | Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. ( Andrade, DM; Chiang, J; del Campo, M; Hamani, C; Hodaie, M; Lozano, AM; Mello, LE; Mirski, M; Sherman, D, 2008) |
| "In the present study, we examined the neuroprotective effects of vitamin C in adult rats after pilocarpine-induced seizures." | 7.74 | Neuroprotective actions of vitamin C related to decreased lipid peroxidation and increased catalase activity in adult rats after pilocarpine-induced seizures. ( Freitas, RL; Freitas, RM; Saldanha, GB; Santos, LF; Xavier, SM, 2008) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| " The rat lithium-pilocarpine model, which mimics many features of temporal lobe epilepsy, has been used to study processes leading to the development of recurrent seizures." | 7.74 | The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model. ( Brown, IR; Lively, S, 2008) |
| "Although the presence of profound cognitive disturbances in lithium-pilocarpine-induced spontaneous recurrent seizures (SRS) has been well documented, much less is known about changes in emotional behavior, in this model of temporal lobe epilepsy." | 7.73 | Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures. ( Bidziński, A; Lechowicz, W; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Turzyńska, D; Walkowiak, J; Wierzba-Bobrowicz, T, 2005) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 7.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| " We tested this hypothesis by repeatedly assessing granule cell excitability after pilocarpine-induced status epilepticus (SE) and monitoring granule cell behavior during 235 spontaneous seizures in awake, chronically implanted rats." | 7.73 | Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis. ( Harvey, BD; Sloviter, RS, 2005) |
| "Seizures were induced in female Wistar albino rats at either 35 or 55 days of age with a single systemic injection of lithium (3 mEq/kg) and pilocarpine (30 mg/kg); the rats were then treated with the atypical neuroleptic acepromazine (25 mg/kg)." | 7.73 | Extreme obesity in female rats following prepuberal induction of lithium-pilocarpine seizures and a single injection of acepromazine. ( Persinger, MA; St-Pierre, LS, 2005) |
| " Its antiepileptic properties have been proved in various animal models, including pilocarpine-induced seizures in adult rats." | 7.73 | Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. ( D'alva, MS; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Sousa, FC; Vasconcelos, SM, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " Furthermore, we examined whether the MRP2 protein is overexpressed after experimentally induced seizures in rats, using the pilocarpine model of temporal lobe epilepsy." | 7.73 | Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. ( Gastens, AM; Hoffmann, K; Löscher, W; Volk, HA, 2006) |
| "We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1." | 7.73 | Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure. ( Gordon, RK; Nambiar, MP; Ratcliffe, RH; Rezk, PE; Steele, KE; Tetz, LM, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.73 | Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2006) |
| "In the pilocarpine model of chronic limbic seizures, vulnerability of GABAergic interneurons to excitotoxic damage has been reported in the hippocampal CA1 region." | 7.72 | Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures. ( Ben-Ari, Y; Dinocourt, C; Esclapez, M; Freund, TF; Petanjek, Z, 2003) |
| " Most animals present seizures at rest rather than during exercise and LCMRglu was measured during the interictal phase of the chronic period of a pilocarpine model of epilepsy by the [14C]2-deoxyglucose (2DG) method." | 7.72 | Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy. ( Arida, RM; Cavalheiro, EA; Fernandes, MJ; Preti, SC; Scorza, FA, 2003) |
| "To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine." | 7.72 | Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development. ( Janeczko, K; Kłak, K; Setkowicz, Z, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 7.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 7.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 7.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 7.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 7.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 7.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| " We show here that another form of status epilepticus, induced by administration of the muscarinic agonist pilocarpine, produces changes in zinc that are essentially the same as those produced by the kainic acid-induced seizures." | 7.71 | Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. ( Frederickson, CJ; Suh, SW; Thompson, RB, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 7.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 7.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 7.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " To address this issue further, we asked whether the new hilar granule cells were active during spontaneous limbic seizures that follow status epilepticus induced by pilocarpine injection." | 7.71 | Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 7.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| "The effects of kappa opioids on seizures and seizure-induced histopathology were investigated with the pilocarpine model of temporal lobe epilepsy." | 7.70 | Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology. ( Bausch, SB; Chavkin, C; Esteb, TM; Terman, GW, 1998) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 7.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 7.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| "The expression of mRNA coding for prepro-thyrotropin releasing hormone (preproTRH) was estimated in the rat brain in two animal models of limbic seizures, evoked by systemic administration of pilocarpine (400 mg/kg ip) or kainate (12 mg/kg ip)." | 7.70 | Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain. ( Budziszewska, B; Jaworska-Feil, L; Lasoń, W; Leśkiewicz, M; Przewłocka, B; Turchan, J, 1999) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 7.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "The present microdialysis study was aimed at evaluating the anticonvulsant effect of the adenosine A(1) receptor agonist 2-chloroadenosine (2-CADO) against pilocarpine-induced seizures in rats." | 7.70 | Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 7.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "Estimates of neuronal dropout for approximately 100 structures as defined by Paxinos-Watson were completed for brains of male Wistar albino rats between 1 and 50 days after status epilepticus was evoked by a single systemic injection of lithium and pilocarpine." | 7.70 | Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat. ( Mastrosov, L; Parker, G; Peredery, O; Persinger, MA, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 7.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| " We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation." | 7.69 | Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. ( Barbier, P; Corsini, GU; Donati, E; Fumagalli, F; Maggio, R; Racagni, G; Riva, M, 1995) |
| "A decrease in the latency for the overt display of limbic seizures following the systemic injection of lithium and pilocarpine is weakly associated with enhanced global geomagnetic activity (in nanoTesla; nT)." | 7.69 | Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla. ( Bureau, YR; Persinger, MA, 1995) |
| "Involvement of the kappa opioid receptor in regulation of the pilocarpine-induced seizures and neurodegeneration was studied in mice." | 7.69 | Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse. ( Lasoń, W; Machelska, H; Przewłocka, B, 1994) |
| "The biologically active enantiomer (CGP 40116) of the new competitive N-methyl-D-aspartate (NMDA) receptor antagonist CGP 37849 was investigated for its effects on pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse." | 7.69 | The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse. ( Starr, BS; Starr, MS, 1994) |
| "The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats." | 7.69 | Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| " To determine if these D3 receptors were capable of attenuating limbic motor seizures induced by pilocarpine, dopamine agonists with preferential or non-selective D3 affinity were injected stereotaxically into these limbic brain regions of the rat via indwelling cannulae prior to pilocarpine challenge." | 7.69 | Effects of dopamine D3 receptor agonists on pilocarpine-induced limbic seizures in the rat. ( Alam, AM; Starr, MS, 1994) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 7.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| " Lithium pretreatment potentiated IEG expression induced by 30 mg/kg pilocarpine, likely as a result of the seizures caused by this combination of drugs because pretreatment with anticonvulsants (diazepam or MK-801) blocked seizures and the enhanced IEG mRNA levels." | 7.69 | Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Aggressive behaviors (numbers of bites/hour) within groups (ns = 8) of normal rats and rats in which seizures had been induced by a single systemic injection of lithium/pilocarpine were observed for 11 successive, 1-hr, periods." | 7.69 | Association between intermale social aggression and cellular density within the central amygdaloid nucleus in rats with lithium/pilocarpine-induced seizures. ( Desjardins, D; Persinger, MA, 1995) |
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 7.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 7.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| " To understand better the potential role played by prohormone convertases in the central nervous system we studied the expression of their messenger RNAs in the hippocampus of rats with pilocarpine-induced seizures." | 7.69 | Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression. ( Avoli, M; Chrétien, M; Day, R; Marcinkiewicz, M; Nagao, T; Seidah, NG, 1997) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 7.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 7.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "The effects of pilocarpine- and kainate-induced seizures on N-methyl-D-aspartate receptor subunit-1 messenger RNA and [3H]dizocilpine maleate binding were studied in the rat hippocampal formation." | 7.69 | Effects of pilocarpine and kainate-induced seizures on N-methyl-D-aspartate receptor gene expression in the rat hippocampus. ( Labuz, D; Lasón, W; Machelska, H; Przewłocka, B; Przewłocki, R; Turchan, J, 1997) |
| " Pilocarpine administration has been used as an animal model for temporal lobe epilepsy since it produces several morphological and synaptic features in common with human complex partial seizures." | 7.69 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 7.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 7.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "The sensitivity of pilocarpine-induced seizures to NMDA receptor blockade with MK-801, or to inhibition of synthesis of the second messenger nitric oxide (NO) with N omega-nitro-L-arginine methyl ester (L-NAME), was studied in mice." | 7.68 | Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME. ( Starr, BS; Starr, MS, 1993) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 7.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 7.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| " Therefore, the concentrations of three second messengers, inositol 1,4,5 trisphosphate (Ins 1,4,5P3), cyclic adenosine monophosphate (AMP), and cyclic guanosine monophosphate (GMP), were measured in rat cerebral cortex and hippocampus after acute or chronic lithium administration, as well as after treatment with the cholinergic agonist pilocarpine alone or in combination with lithium at a dose that induces seizures only in lithium pretreated rats." | 7.68 | Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. ( Jope, RS; Kolasa, K; Song, L, 1992) |
| "Between 30 and 50 days after the induction of seizures by a single injection of lithium and pilocarpine, large aggregates of Nissl-staining material appeared; they occupied up to 35% of the thalamic volume." | 7.68 | Progressive accumulation of large aggregates of calcium-containing polysaccharides and basophilic debris within specific thalamic nuclei after lithium/pilocarpine-induced seizures. ( Lafreniere, GF; Peredery, O; Persinger, MA, 1992) |
| " The object of this study was to determine the effect of SCC on behavioral and EEG symptomatology in the lithium-pilocarpine model of seizures and status epilepticus in the rat." | 7.68 | Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus. ( Gilles, F; Hirsch, E; Snead, OC; Vergnes, M, 1992) |
| "The present study addressed the role of dopamine D1 receptors in pilocarpine-induced motor seizures in rats." | 7.68 | Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors. ( Alam, AM; Starr, MS, 1992) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 7.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| "Previous studies with lithium have shown that it potentiated the in vivo response to cholinomimetics in rats, resulting in seizures at otherwise non-convulsant doses, but did not affect seizure activity induced by a number of chemical convulsants including kainic acid and N-methyl-D-aspartate (NMDA)." | 7.68 | Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate. ( Jope, RS; Ormandy, GC, 1991) |
| "The prepiriform cortex (PPCx) shows high sensitivity to the epileptogenic action of chemo-convulsants and to the protective action of the NMDA receptor antagonist, 2-amino-7-phosphono-heptanoate (APH) against pilocarpine-induced (motor) limbic seizures in rats." | 7.67 | The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "The characteristics and consequences of limbic seizures evoked by single peripheral injections of lithium (3 mEq/kg) and pilocarpine (30 mg/kg) were investigated over a three-year period." | 7.67 | Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. ( Bradley, JC; Makarec, K; Persinger, MA, 1988) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 7.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Seizures produced by pilocarpine given i." | 7.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "Microinjection of muscimol (406 pmol) into the rat entopeduncular nucleus, the analogue of the primate globus pallidus pars interna, significantly suppressed pilocarpine but not maximal electroshock seizures in a spatially specific manner." | 7.67 | Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats. ( Hosford, DA; McNamara, JO, 1988) |
| "The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain." | 7.67 | Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou-Turski, C; Kleinrok, Z; Turski, L; Turski, WA, 1988) |
| "Limbic seizures were evoked in rats by single subcutaneous injections of lithium and pilocarpine that are known to elicit severe damage to gustatory-affective centers in the brain." | 7.67 | Conditioned taste aversion is reduced in rats with a history of lithium/pilocarpine-induced limbic seizures. ( Persinger, MA; Venugopal, M, 1988) |
| "Seizures produced in rats by systemically administered pilocarpine (PILO) provide a model for studying the generation and spread of convulsive activity in the forebrain." | 7.67 | Only certain antiepileptic drugs prevent seizures induced by pilocarpine. ( Cavalheiro, EA; Coimbra, C; da Penha Berzaghi, M; Ikonomidou-Turski, C; Turski, L; Turski, WA, 1987) |
| "Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain." | 7.67 | Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra. ( Bortolotto, ZA; Cavalheiro, EA; De Moraes Mello, LE; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA, 1986) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 7.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats." | 7.67 | Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1986) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 7.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "The effects of 2-chloroadenosine, aminophylline, bicuculline, beta-carboline-3-carboxylic acid methylester and Ro 15-1788 on seizures produced by pilocarpine were examined in rats." | 7.67 | Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Mello, LE; Turski, L; Turski, WA, 1985) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 7.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 6.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Taurine (Tau) is an osmosensitive amino acid, whose release reflects increased cell volume." | 5.91 | Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus. ( Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Pawlik, M; Podgajna, M; Skowrońska, K; Węgrzynowicz, M, 2023) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 5.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 5.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 5.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| "However, the effect of seizures on Cx expression is controversial." | 5.72 | Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus. ( Andrioli, A; Barresi, V; Bentivoglio, M; Condorelli, DF; Di Liberto, V; Fabene, PF; Frinchi, M; Mudò, G, 2022) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 5.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 5.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region." | 5.51 | Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy. ( Barbieri, M; Bell, WJ; Emerich, DF; Falcicchia, C; Fradet, T; Kokaia, M; Lovisari, F; Paolone, G; Simonato, M; Wahlberg, LU, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 5.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Behavioral (latency to first seizure and the percentage of clonic forelimb seizures), biochemical, and oxidative stress parameters were evaluated." | 5.48 | Gamma-Decanolactone Improves Biochemical Parameters Associated with Pilocarpine-Induced Seizures in Male Mice. ( Coelho, VR; da Silva, LL; Hoffmann, C; Nascimento, L; Pereira, P; Pfluger, P; Picada, JN; Regner, GG; Saffi, J; Viau, CM; Zanette, RA, 2018) |
| " It is concluded that chronic administration β-estradiol has anticonvulsant and neuroprotective properties which are plausibly linked to astrocytic activity." | 5.46 | Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkar Boluki, T; Sarfi, M, 2017) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 5.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Since traumatic brain injury is one of the strongest determinants of epileptogenesis, the present study focuses on the question whether a moderate long-term physical training can decrease susceptibility to seizures evoked following brain damage." | 5.43 | Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain. ( Gzieło-Jurek, K; Janeczko, K; Kaczyńska, M; Kosonowska, E; Setkowicz, Z, 2016) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 5.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Rosmarinic acid is a naturally occurring substance which displays several biological effects including antioxidant and neuroprotective activity." | 5.43 | Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. ( Freitas, ML; Furian, AF; Grauncke, AC; Grigoletto, J; Oliveira, CV; Oliveira, MS; Santos, AR; Souto, NS; Souza, TL, 2016) |
| "Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases." | 5.43 | Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. ( Chen, L; Chen, Y; Feng, Y; Li, B; Luo, Q; Shao, Y; Xie, Y, 2016) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 5.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "However, its role in seizures and postictal outcomes is still not fully understood." | 5.42 | PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. ( Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB, 2015) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "EEG documented seizure activity and status epilepticus (SE) developed in 87." | 5.39 | Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. ( Chang, FC; Jou, SB; Kao, IF; Yi, PL, 2013) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 5.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 5.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Pilocarpine treatment significantly reduced the GAP-43 immunoreactivity in the inner molecular layer in both species, with some minor differences in the staining pattern." | 5.37 | Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy. ( Dobó, E; Károly, N; Mihály, A, 2011) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 5.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "In pilocarpine group, it was observed a significant decreased in ChAT and AChE activities, when compared to control group." | 5.36 | Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. ( de Freitas, RM; de Sales Santos, IM; Feitosa, CM, 2010) |
| "In pilocarpine group there was a significant increase in hydroperoxides concentration and glutathione peroxidase activity." | 5.36 | Effects of ubiquinone on hydroperoxide concentration and antioxidant enzymatic activities in the rat hippocampus during pilocarpine-induced seizures. ( da Silva, EP; de Freitas, RL; de Freitas, RM; Feitosa, CM; Feng, D; Saldanha, GB; Santos, IM; Souza, GF; Tomé, Ada R, 2010) |
| "In the remaining animals that exhibited seizures, KB-R7943 pretreatment delayed the onset of seizures and status epilepticus, and reduced seizure severity." | 5.36 | Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. ( Martinez, Y; N'Gouemo, P, 2010) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "Bromodeoxyuridine (BrdU) was intraperitoneally administered 36h before the rats were sacrificed." | 5.34 | Consequences of pilocarpine-induced recurrent seizures in neonatal rats. ( Ji-Wen, W; Ruo-Peng, S; Xiu-Yu, S, 2007) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 5.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "Epileptic seizures cause severe and long-lasting events on the architecture of the brain, including neuronal cell death, accompanied neurogenesis, reactive gliosis, and mossy fiber sprouting." | 5.33 | Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. ( Hagihara, H; Hara, M; Nakagawa, Y; Nakano, K; Sawada, M; Tsunekawa, K, 2005) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 5.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "Thereafter, seizures were induced by pilocarpine injections in trained and non-trained control groups." | 5.33 | Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat. ( Mazur, A; Setkowicz, Z, 2006) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 5.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "The numbers of spontaneous seizures per day during a 15 min observation interval were recorded for each rat during the treatment period and during an additional 30 days when only tap water was given." | 5.32 | Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures. ( Peredery, O; Persinger, MA, 2004) |
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 5.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 5.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine." | 5.31 | Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. ( Shibley, H; Smith, BN, 2002) |
| "The principal elements of the seizures are wet-rat-shakes, facial and forelimb clonus, rearing and spike-and-waves in the EEG." | 5.30 | The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine. ( Dürmüller, N; Graham, JL; Meldrum, BS; Sowinski, P, 1997) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 5.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression." | 5.30 | Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 5.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| "These seizures were followed by seemingly complete neurological recovery." | 5.29 | Long-term behavioral deficits following pilocarpine seizures in immature rats. ( Gatt, A; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ, 1994) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 5.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| "We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine." | 5.29 | Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "We have used the pilocarpine-induced seizure model in mice and i." | 5.29 | Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. ( Deirmengiant, C; Maslanski, JA; Patelt, J; Powelt, R, 1994) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 5.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "Here we evaluated whether spontaneous seizures would lead to similar impairments." | 5.29 | Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. ( Covolan, L; Mello, LE, 1996) |
| "Subsequently electrographic seizures appeared in both limbic and cortical leads." | 5.27 | Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. ( Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Schwarz, M; Turski, L; Turski, WA, 1983) |
| "Organized electrographic seizure activity developed just prior to the onset of behavioral forelimb clonus and appeared to originate from ventral forebrain in the vicinity of the ventral pallidum and/or nucleus accumbens." | 5.27 | The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. ( Clifford, DB; Collins, RC; Maniotis, A; Olney, JW; Zorumski, CF, 1987) |
| "No overt motor seizures were observed in this age group." | 5.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 5.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 4.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| " Among post-status epilepticus models, induction of systemic kainic acid or pilocarpine-induced epilepsy is less labor-intensive than electrical-stimulation models and these models mirror the clinicopathologic features of MTLE more closely than do kindling, tetanus toxin, hyperthermia, post-traumatic, and perinatal hypoxia/ischemia models." | 4.84 | Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. ( Jordan, WH; Miller, MA; Reams, RY; Sharma, AK; Snyder, PW; Thacker, HL, 2007) |
| "Local or systemic administration of pilocarpine and kainate in rodents leads to a pattern of repetitive limbic seizures and status epilepticus, which can last for several hours." | 4.81 | New insights from the use of pilocarpine and kainate models. ( Cavalheiro, EA; Garcia-Cairasco, N; Leite, JP, 2002) |
| "High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration." | 4.77 | Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Turski, L; Turski, WA, 1989) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 4.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| "9% saline, n = 5), the EP groups (lithium-pilocarpine was used to induce epilepsy, and tissues were harvested at 6 and 24 h, every time point, n = 5), the EP + Compound C group (the specific inhibitor of PGC-1α, 15 mg/kg in 2% DMSO, n = 5), and the EP + DMSO group (0." | 4.31 | PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats. ( Li, D; Liu, X; Luo, Z; Qiu, X; Tai, Z; Tuo, J; Wang, J; Xu, Z; Yang, J; Zhang, F; Zhang, H; Zhang, L, 2023) |
| "05) and STR (42%) and had no effect on pilocarpine-induced seizures." | 4.31 | Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. ( Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 4.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " The aim of this study was to investigate the mechanism of action of ASP and GP through the experimental model of pilocarpine-induced seizures." | 4.31 | Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice. ( da SilvaTorres, IL; de Oliveira, JDM; Medeiros, HR; Pereira, P; Pflüger, P; Picada, JN; Uczay, M; Vendruscolo, MH; von Poser, G, 2023) |
| "The objective of this work was to evaluate the antiseizure effect of the antioxidants allopurinol (ALL) and ellagic acid during status epilepticus induced by pilocarpine (PILO)." | 4.31 | Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus. ( Martínez-Gallegos, S; Medina-Ceja, L; Pardo-Peña, K; Sánchez-Lira, A, 2023) |
| " In this study, we investigated the anti-inflammatory action of eugenol in an experimental epilepsy model of pilocarpine-induced status epilepticus (SE)." | 4.31 | Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, CH; Kim, WJ; Park, S; Zhu, J, 2023) |
| "The present study was undertaken to investigate the efficacy of a characterized hydroalcoholic extract (NJET) of Nardostachys jatamansi in the lithium-pilocarpine rat model of spontaneous recurrent seizures (SRS) and associated cardiac irregularities." | 4.31 | Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. ( Patial, V; Rahmatkar, SN; Rana, AK; Sharma, S; Singh, D, 2023) |
| "Untreated lithium/pilocarpine SE induced a large increase in aggressive behavior, which involved all aspects of aggression in the resident-intruder paradigm when tested 3 months after SE." | 4.31 | Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus. ( Baldwin, RA; Niquet, J; Suchomelova, L; Thompson, KW; Wasterlain, CG, 2023) |
| " We recently found that in the pilocarpine-induced status epilepticus (PILO-SE) mouse model of TLE there was an increase in CA2 intrinsic excitability associated with a loss of CA2 synaptic inhibition." | 4.31 | Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. ( Barnett, A; Lisgaras, CP; Santoro, B; Scharfman, HE; Siegelbaum, SA; Whitebirch, AC, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 4.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 4.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| "Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase." | 4.12 | Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. ( Amado, D; Amorim, RP; Cossa, AC; da Silva, JC; Dal Pai, J; Predebon, G; Sanabria, V; Trindade-Filho, E, 2022) |
| " Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a novel antiseizure strategy." | 4.12 | Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. ( Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S, 2022) |
| " We here examined for the first time the anticonvulsant effect of TCS2002, a specific and potent inhibitor of GSK-3β, in two models for limbic seizures: the pilocarpine rat model for focal seizures and the acute 6 Hz corneal mouse model for refractory seizures." | 4.12 | Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis. ( Allaoui, W; Aourz, N; De Bundel, D; Smolders, I; Van Eeckhaut, A; Van Leuven, F, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 4.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 4.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| "Intrahippocampal pilocarpine microinjection (H-PILO) induces status epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents." | 4.12 | Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus. ( Amaral, MMC; Borbely, AU; Cummings, RD; de Araujo Costa, M; de Castro, OW; de Gusmão Taveiros Silva, NK; de Melo, IS; Dias-Baruffi, M; Donatti, ALF; Duzzioni, M; Fuzo, CA; Garcia-Cairasco, N; Gitaí, DLG; Mestriner, L; Pacheco, ALD; Santos, YMO; Silva, RS, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 4.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " In fact, decreased expression of ALOXE3 and elevated concentration of AA in the hippocampus was found after status epilepticus (SE) induced by pilocarpine." | 4.12 | Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility. ( Chen, SY; Gao, MM; Long, YS; Lu, P; Su, T; Sun, WW; Tang, HL; Zeng, XD; Zhang, H, 2022) |
| "Initial seizures observed in young rats during the 60 min after administration of pilocarpine (Pilo) were delayed and attenuated by pretreatment with a non-convulsive dose of methionine sulfoximine (MSO)." | 4.02 | Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose. ( Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP, 2021) |
| " Pilocarpine epilepsy model mice with confirmed cluster pattern of spontaneous recurrent seizures by long-term video-electroencpehalography were sacrificed at the onset, peak, or end of a seizure cluster or in the seizure-free period." | 4.02 | Proteins related to ictogenesis and seizure clustering in chronic epilepsy. ( Chu, K; Han, D; Jeon, D; Jung, KH; Lee, SK; Lee, ST; Lee, WJ; Lim, JA; Moon, J; Park, DK; Park, KI; Yoo, JS, 2021) |
| " Therefore, the present study hypothesized an antiepileptic potential of chondroitin sulfate (CS) in pentylenetetrazole-induced kindled epilepsy and pilocarpine-induced status epilepticus in mice." | 4.02 | Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. ( Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG, 2021) |
| " We examined the levels of α-actn-2 expression within the dentate gyrus (DG) during the development of chronic limbic seizures (epileptogenesis) induced by pilocarpine in rats." | 4.02 | The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures. ( Bole, A; Esclapez, M; Ferhat, L; Khrestchatisky, M; Sbai, O; Soussi, R, 2021) |
| "LMR-101 is a bisphenol derivative of propofol, a short-acting general anesthetic, which is also used to manage status epilepticus (SE)." | 4.02 | LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors. ( An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y, 2021) |
| " In the present study, we tested the effects of NRP2945 on the development of epilepsy (epileptogenesis) and on chronic, spontaneous seizures, by using the pilocarpine model of temporal lobe epilepsy." | 4.02 | Anti-epileptogenic effect of NRP2945 in the pilocarpine model of temporal lobe epilepsy. ( Falcicchia, C; Guarino, A; Ingusci, S; Lovisari, F; Marino, P; Sieg, F; Simonato, M; Soukupova, M; Thomas, M, 2021) |
| " Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG)." | 4.02 | Limbic progesterone receptor activity enhances neuronal excitability and seizures. ( Batabyal, T; Joshi, S; Kapur, J; Labuz, A; Shiono, S; Sun, H; Williamson, J, 2021) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 3.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| "The present study tested whether ictal onset sites are regions of more severe interneuron loss in epileptic pilocarpine-treated rats, a model of human temporal lobe epilepsy." | 3.96 | Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats. ( Buckmaster, PS; Nagendran, M; Wyeth, M, 2020) |
| "Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents." | 3.96 | Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity. ( Agam, G; Batra, AS; Belmaker, RH; Blackburn, V; Churchill, GC; Sade, Y; Saiardi, A; Serres, F; Sharp, T; Singh, N; Toker, L; Vasudevan, SR, 2020) |
| " Thereafter, pilocarpine was administered, and significant differences in susceptibility to seizures were detected depending on the degree of brain dysplasia." | 3.96 | Changes of EEG spectra in rat brains with different patterns of dysplasia in response to pilocarpine-induced seizures. ( Gzieło, K; Janeczko, K; Kiełbinski, M; Setkowicz, Z; Węglarz, W, 2020) |
| " Similarly, we found that both focal and generalized seizures coexist in some pilocarpine-induced chronic temporal lobe epilepsy (TLE) rats." | 3.96 | Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat ( Wang, Y; Xu, K; Yang, Y; Zhang, F; Zhu, J, 2020) |
| " Therefore, in the present study, SB203580 was used to inhibit the p38 MAPK signaling pathway in rats, and the expression levels of A1R and ENT1 in the brain tissue of rats with acute LiCl‑pilocarpine‑induced status epilepticus was detected." | 3.96 | Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1. ( Chen, Q; Chen, Y; Feng, Z; Huang, H; Peng, Y; Wang, J; Xu, Z; Zeng, J; Zhang, H; Zhang, J; Zhou, X, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| "To establish the effects induced by long-term, unilateral stimulation of parvalbumin (PV)-positive interneurons on seizures, interictal spikes, and high-frequency oscillations (80-500Hz) occurring after pilocarpine-induced status epilepticus (SE)-a proven model of mesial temporal lobe epilepsy (MTLE)-in transgenic mice expressing or not expressing ChR2." | 3.91 | Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy. ( Avoli, M; Chen, LY; Etter, G; Lévesque, M; Shiri, Z; Wang, S; Williams, S, 2019) |
| "Based on combined behavioral, biochemical, and physiological analyses, we assessed the impact on animal well-being and condition in different phases of the pilocarpine post-status epilepticus (SE) model in rats." | 3.91 | Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model. ( Di Liberto, V; Hellweg, R; Koska, I; Möller, C; Palme, R; Potschka, H; Seiffert, I; van Dijk, RM, 2019) |
| " In the CA1 region of hippocampus less GABAergic activity precede the appearance of spontaneous seizures and calpain overactivation has been detected after chemoconvulsant-induced status epilepticus (SE)." | 3.91 | Calpain-dependent cleavage of GABAergic proteins during epileptogenesis. ( González, MI, 2019) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 3.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| " The aim of the present study was to determine if modulation by PPAR-γ could attenuate pilocarpine-induced seizures and decrease neuronal excitability." | 3.91 | The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity. ( Chu, FL; Huang, CW; Hung, TY; Wu, DC; Wu, SN, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 3.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| " Status epilepticus (SE) was induced via systemic injection of pilocarpine." | 3.91 | Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment. ( Huang, H; Huang, M; Lin, R; Lin, W; Liu, C; Ma, Y; Wen, Y, 2019) |
| " Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy." | 3.91 | Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms. ( Chaves-Filho, A; de Carvalho Lima, CN; de Carvalho, MAJ; de França Fonteles, MM; de Lima, KA; de Souza, AG; de Souza, DAA; de Souza, FCF; Feitosa, ML; Macedo, DS; Rios Vasconcelos, ER; Souza Oliveira, JV, 2019) |
| " We examined the impact of early minor activation of TLR4 and TLR2 on the severity of seizure in the pilocarpine rat model of temporal lobe epilepsy (TLE)." | 3.91 | Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. ( Daftari, M; Hosseinzadeh, M; Khodagholi, F; Motamedi, F; Naderi, N; Pourbadie, HG, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "Adult female rats that developed epilepsy following lithium-pilocarpine-induced status epilepticus (SE) were used." | 3.91 | Progesterone receptor activation regulates seizure susceptibility. ( Joshi, S; Kapur, J; Shiono, S; Williamson, J, 2019) |
| "The present study was designed to understand the molecular changes and cardiac parameters during different phases of epileptogenesis in lithium-pilocarpine (Li-pilo) rat model of epilepsy." | 3.91 | Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management. ( Mazumder, AG; Patial, V; Rana, AK; Sharma, S; Singh, D, 2019) |
| " The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction on seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), pilocarpine (PC) and its possible action mechanisms in animal models using flumazenil (FLU), methyl-ß-carboline-3-carboxylate (BC) and bicuculline (BIC)." | 3.88 | Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock. ( Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G, 2018) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 3.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| " Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies." | 3.88 | Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. ( Canzian, JM; Duarte, MMMF; Duarte, T; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS, 2018) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 3.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| " Here, we studied overlapping HFOs during spontaneous seizures in pilocarpine-treated animals." | 3.88 | High frequency oscillations in epileptic rodents: Are we doing it right? ( Avoli, M; Gotman, J; Lévesque, M; Wang, S, 2018) |
| " Considering the importance in developing therapeutic strategies to prevent or modify epileptogenesis, we aimed the present study to test the hypothesis that atorvastatin modifies seizure susceptibility of mice after status epilepticus (SE)." | 3.88 | Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. ( Fighera, MR; Furian, AF; Oliveira, CV; Oliveira, MS; Royes, LFF; Zorzi, VN, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| "In this research, rat model of epilepsy was established by pilocarpine induction." | 3.88 | LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway. ( Fan, WF; Geng, JF; Geng, JJ; Liu, X; Liu, XZ; Zhao, HB, 2018) |
| " We found that different doses of lithium affect epileptic seizure activity and bidirectionally modulate the susceptibility to and severity of seizures induced by pilocarpine in rats." | 3.88 | Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner. ( Cao, X; Jiang, G; Li, Z; Pu, T; Wang, X; Yu, J; Zhang, X; Zhou, R, 2018) |
| " Besides that, the reconstituted powder containing chitosan-coated nanocapsules exhibited improved anticonvulsant activity against seizures induced by pilocarpine in mice, compared to the non-encapsulated drug, representing an important approach in anticonvulsant treatments for children and adults." | 3.88 | Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice. ( Beck, RCR; Cardoso, AM; Coradini, K; de Oliveira, CV; de Oliveira, EG; Guterres, SS; Oliveira, MS; Paese, K; Pohlmann, AR, 2018) |
| " The GA group was given GA (150 μg/kg, ip) and the control group was given a saline injection prior to pilocarpine-induced seizures." | 3.88 | The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures. ( Huang, CW; Lai, MC; Lin, KM; Wu, SN; Yeh, PS, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 3.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| " The first experimental block included a Pilocarpine rat model of epilepsy, in which a magnetic neodymium nickel-plated cylinder, a magnetic field of 0." | 3.88 | Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey. ( Aguila, J; Aguilar, J; Coletti, M; Cudeiro, J; Prieto, S; Rivadulla, C, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "Vascular endothelial growth factor (VEGF) treatment during pilocarpine-induced status epilepticus (SE) causes sustained preservation of behavioral function in rats in the absence of enduring neuroprotection (Nicoletti et al." | 3.85 | VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology. ( Croll, SD; Lenzer-Fanara, JR; Li, T; Payen, F; Salerni, EA, 2017) |
| " In this study, we ablated the hippocampal neurogenesis by methylazoxymethanol acetate (MAM) treatment both before and after pilocarpine induced status epilepticus (SE)." | 3.85 | Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice. ( Feng, GF; Hu, M; Liu, JX; Liu, Y; Yuan, B; Zhu, K, 2017) |
| "The present results indicate that tangeretin exerted potent neuroprotective effects against pilocarpine-induced seizures via the activation of PI3K/Akt signaling and the regulation of MMPs." | 3.85 | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. ( Cao, YL; Guo, XQ; Hao, F; Liu, XW; Wang, ML; Yan, ZR, 2017) |
| " In epileptic rats analyzed up to approximately two weeks after pilocarpine-induced status epilepticus (SE), these patterns are associated with specific high-frequency oscillation (HFO) content: ripples (80-200Hz) or fast-ripples (250-500Hz) predominate in LVF or HYP seizures, respectively." | 3.85 | Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Stroh, T, 2017) |
| " Inhibition of SALM3 by SALM3 shRNA inhibited status epilepticus in the acute stage of disease and decreased spontaneous recurrent seizures in the Lithium-pilocarpine model of chronic stages of epilepsy." | 3.85 | Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models. ( Chen, L; Jiang, G; Li, J; Wang, N; Wu, Y; Zhang, Y, 2017) |
| " To tackle this issue, we determined the frequency of seizures and the total number of hippocampal cells throughout the life of rats with epilepsy using the pilocarpine model." | 3.83 | Relationship between seizure frequency and number of neuronal and non-neuronal cells in the hippocampus throughout the life of rats with epilepsy. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Lent, R; Lopim, GM; Vannucci Campos, D, 2016) |
| " Herein, we confirmed that pilocarpine application promptly (<30 min) induces status epilepticus (SE) as revealed by changes in rat electrocorticogram particularly in fast-beta range (21-30 Hz)." | 3.83 | Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. ( Britto, LR; Damico, MV; de Sousa, E; Higa, GS; Kihara, AH; Kinjo, ER; Morya, E; Santos, BA; Valle, AC; Walter, LT, 2016) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 3.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| "To elucidate the impact of maternal seizures in the developing rat brain, pregnant Wistar rats were subjected to the pilocarpine-induced seizures and pups from different litters were studied at different ages." | 3.83 | Maternal seizures can affect the brain developing of offspring. ( Amado, D; Cossa, AC; da Graça Naffah-Mazzacoratti, M; da Silva Fernandes, MJ; de Alencar Rocha, AK; do Vale, TG; Lima, DC, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 3.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "2 promoter activation, were imaged in vivo in the pilocarpine model of status epilepticus (SE)." | 3.81 | Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. ( Becker, AJ; Kulbida, R; Mandelkow, EM; Schoch, S; van Loo, KM; Wang, Y, 2015) |
| " We investigated the effects of ketogenic diets (KDs) containing coconut oil, triheptanoin, or soybean oil on pilocarpine-induced status epilepticus (SE) in rats." | 3.81 | Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. ( Barros, EM; Bueno, NB; Cabral-Junior, CR; da Rocha Ataide, T; Domingos, BR; Ferreira, RC; Galvão, JA; Gama, IR; Melo, IT; Oliveira, SL; Pereira, WS; Trindade-Filho, EM, 2015) |
| " This study evaluated the dynamin 1 expression pattern in the acute lithium-pilocarpine rat model and in patients with temporal lobe epilepsy (TLE) and investigated whether altering the dynamin 1 expression pattern affects epileptic seizures in vivo and in vitro." | 3.81 | Upregulated dynamin 1 in an acute seizure model and in epileptic patients. ( Chen, XN; Fan, XX; Fu, XW; Gu, J; Li, YY; Wang, XF; Wang, ZH; Xiao, Z; Zhang, YJ, 2015) |
| "Nimodipine has been shown to have an inhibitory action on seizures and brain damage in rodents." | 3.81 | Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice. ( Cavalcanti, IM; Freitas, RM; Moreno, LC; Rolim, HM; Santos-Magalhães, NS; Satyal, P, 2015) |
| "A common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine, yet the mechanisms underlying the induction of pilocarpine-induced seizures (PISs) remain unclear." | 3.81 | Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. ( DeCan, E; Deisseroth, K; Lawrence, JJ; Marceau, E; Stoll, K; Yi, F, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| " In the present study we studied seizure susceptibility along the longitudinal axis of the hippocampus following pilocarpine-induced status epilepticus (SE)." | 3.81 | Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. ( Holmes, GL; Isaev, D; Isaeva, E; Romanov, A, 2015) |
| " Ripples (80-200 Hz) and fast ripples (250-500 Hz) have been linked to each pattern, with ripples predominating during LVF seizures and fast ripples predominating during HYP seizures in the rat pilocarpine model." | 3.81 | Distinct EEG seizure patterns reflect different seizure generation mechanisms. ( Avoli, M; Gotman, J; Lévesque, M; Salami, P, 2015) |
| " To evaluate the possible roles of inhibitory neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of epileptic pilocarpine-treated rats as they experienced spontaneous seizures." | 3.81 | Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy. ( Buckmaster, PS; Fujita, S; Thamattoor, AK; Toyoda, I, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 3.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| " In two-month-old survivors of the inflammatory status, seizures were evoked with pilocarpine injection." | 3.81 | Inflammation induced at different developmental stages affects differently the range of microglial reactivity and the course of seizures evoked in the adult rat. ( Janeczko, K; Kosonowska, E; Setkowicz, Z, 2015) |
| " In this study, apart from unravelling the effect of des-acyl ghrelin on seizure thresholds and seizure severity in two models of pilocarpine-induced seizures, we mainly attempted to unravel its anticonvulsant mechanism of action." | 3.81 | Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway. ( Coppens, J; Demuyser, T; Portelli, J; Smolders, I, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| " In this study, we used the pilocarpine model of MTLE to establish the effects of a third generation drug, lacosamide (LCM), on seizures, interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz)." | 3.81 | Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Ragsdale, D, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 3.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 3.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "Inflammation was induced by injecting poly(I:C) (pIC 10 mg/kg, postnatal day 12-14), seizure was induced by injecting pilocarpine hydrochloride (PILO 200 mg/kg, postnatal day 15) into C57BL/6J mice, and the pIC+PILO mice were used as the iSE model (miSE)." | 3.81 | Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. ( Hirai, S; Morio, T; Nakajima, K; Okado, H, 2015) |
| "The objective of this study was to evaluate the potential anticonvulsant effect of isopentyl ferulate, a new ester derived from ferulic acid in mice (Mus musculus) subjected to two models of induced seizures." | 3.81 | Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate. ( De Sousa, DP; Freitas, RM; Islam, MT; Junior, AL; Machado, KC; Oliveira, GL, 2015) |
| "Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively." | 3.81 | Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. ( Chen, XM; Huang, LF; Liang, JJ; Lu, ZN; Pan, SQ; Xiao, ZM, 2015) |
| " This study aimed to investigate the expression pattern of Letm1 in patients with temporal lobe epilepsy (TLE) and pilocarpine-induced rat model of epilepsy, and to determine if altered Letm1 leads to mitochondrial dysfunction and increased susceptibility to seizures." | 3.80 | Association of mitochondrial letm1 with epileptic seizures. ( Cao, Q; Chen, G; Fang, M; Liu, J; Lu, Y; Luo, J; Wang, X; Zhang, X, 2014) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 3.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| " We found that subchronic treatment (4 days) with Nω-nitro-l-arginine reduced the down-regulation of muscarinic receptors induced by pilocarpine and kainic acid in rat fronto-parietal cortex, notwithstanding the dramatic potentiation of seizures induced by both convulsants." | 3.80 | Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex. ( Aloisi, G; Capannolo, M; Ciccarelli, C; Fasciani, I; Fumagalli, F; Maggio, R; Molteni, R; Riva, MA; Rocchi, C; Romeo, S; Zani, BM, 2014) |
| "Status epilepticus (SE) was induced by intraperitoneal injection of 340mg/kg pilocarpine, and terminated by diazepam after 40min." | 3.80 | Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures. ( Groeneweg, L; Kirschstein, T; Köhling, R; Müller, L; Müller, S; Sellmann, T; Tokay, T, 2014) |
| "The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats." | 3.80 | Neuroprotective effects of idebenone against pilocarpine-induced seizures: modulation of antioxidant status, DNA damage and Na(+), K (+)-ATPase activity in rat hippocampus. ( Ahmed, MA, 2014) |
| "To investigate the possible role of bone marrow-derived cells in angiogenesis after seizures, we induced SE by pilocarpine injection in previously prepared chimeric mice." | 3.80 | Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus. ( Bittencourt, S; Covolan, L; Garcia, Kde O; Longo, BM; Mello, LE; Paiva, Dde S; Romariz, SA, 2014) |
| "Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy." | 3.80 | Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. ( Jiang, K; Kow, RL; Le, JH; Nathanson, NM; Naydenov, AV; Stella, N, 2014) |
| " We report that, among a spectrum of in vivo activities, both 15b and 15c displayed significant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.80 | Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides. ( Filipek, B; Höfner, GC; Kowalczyk, P; Kulig, K; Mucha, M; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT, 2014) |
| " Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the main features of mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) in humans, we examined the expression of CB1R in hippocampal astrocytes of epileptic rats." | 3.80 | Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi. ( Jiang, W; Kang, JJ; Li, J; Liu, YY; Ma, L; Meng, XD; Ou-Yang, TP; Wei, D; Wu, C; Yang, F; Zhu, GM, 2014) |
| " However, it is still not known whether puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures." | 3.80 | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. ( Lian, Y; Wang, C; Wu, C; Xie, N; Zhang, H; Zhang, Q, 2014) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| " To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expression of key components in the glutamate-glutamine cycle, known to be affected in MTS patients." | 3.80 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 3.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| "We pretreated mice with MG before seizure induction with picrotoxin or pilocarpine and then assessed seizures behaviorally or by electroencephalography (EEG)." | 3.79 | Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. ( Distler, MG; Escayg, A; Gorfinkle, N; Palmer, AA; Papale, LA; Termini, J; Winawer, MR; Wuenschell, GE, 2013) |
| " And that VMAT2 protein transiently increased in acute stages (1 day and 3 days) after epileptic seizures in pilocarpine-treated rats; however, it clearly decreased after spontaneous recurrent seizures (7 days, 21 days, and 60 days after seizures)." | 3.79 | Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats. ( Cao, Q; Chen, G; Chen, Y; Guo, F; Jiang, G; Li, J; Liu, X; Wang, X; Wang, Z; Zhang, Y, 2013) |
| " In this study, we examined the role of mdivi-1 in hippocampal neuron death after seizures induced by pilocarpine." | 3.79 | A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. ( Lian, Y; Wang, C; Wu, C; Xie, N; Zhang, H; Zhang, Q, 2013) |
| ") administration of α-MSH altered PTZ- and pilocarpine-induced seizures." | 3.79 | Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures. ( Guerra, GP; Jesse, AC; Lenz, QF; Marafiga, JR; Mello, CF; Oliveira, SM; Santos, AC; Scimonelli, TN; Temp, FR, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 3.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| " However, whether there is a neuroprotective effect of AG in hippocampal neurons of pilocarpine-induced seizures in rats, is still unknown." | 3.79 | Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis. ( Guo, F; Wang, H; Wang, Q; Yang, G; Zhang, R, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "The objective was to study the behavioral effect of the specific competitive IMPase inhibitor L-690,330 in mice in the lithium-sensitive pilocarpine-induced seizures paradigm and the forced swim test (FST)." | 3.79 | The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test. ( Agam, G; Belmaker, RH; Bersudsky, Y; Shtein, L; Toker, L, 2013) |
| "The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice." | 3.79 | Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice. ( Cavalcante Melo, FH; de Carvalho Lima, CN; de França Fonteles, MM; Freire Vasconcelos, L; Leite Dias, M; Moura Rocha, NF; Rodrigues Carvalho, AM; Soares Lopes, K; Vasconcelos Rios, ER, 2013) |
| "Loss of neurons occurs with aging and following lithium/pilocarpine-induced epileptic seizures." | 3.79 | Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains. ( Karbowski, LM; Parker, GH; Persinger, MA, 2013) |
| "This study was designed to investigate the effects of β-hydroxybutyrate (BHB) on pilocarpine-induced seizures in young mice." | 3.78 | β-Hydroxybutyrate increases the pilocarpine-induced seizure threshold in young mice. ( Kim, DW; Ko, TS; Yum, MS, 2012) |
| " Here we show that mice with decreased CREB levels (CREB(α∆) mutants) have a ~50% reduction in spontaneous seizures following pilocarpine induced status epilepticus (SE) and require more stimulation to electrically kindle." | 3.78 | Decreased CREB levels suppress epilepsy. ( Blendy, JA; Han, X; Porter, BE; Zhu, X, 2012) |
| "In the present work, synchrotron radiation Fourier-transform infrared (SRFTIR) and Raman microspectroscopies were used to evaluate a possible role of creatine in the pathogenesis and progress of pilocarpine-evoked seizures and seizure-induced neurodegenerative changes in the rat hippocampal tissue." | 3.78 | Synchrotron radiation Fourier-transform infrared and Raman microspectroscopy study showing an increased frequency of creatine inclusions in the rat hippocampal formation following pilocarpine-induced seizures. ( Chwiej, J; Dulinska, J; Dumas, P; Gzielo-Jurek, K; Janeczko, K; Sandt, C; Setkowicz, Z; Uram, L, 2012) |
| " Finally, we investigated its effects on pilocarpine-induced seizures in rats." | 3.78 | Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. ( Chow, JC; Huang, CW; Tsai, JJ; Wu, SN, 2012) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 3.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| " Pilocarpine was subsequently co-administered with NPY or D-His26-NPY to determine their effect on pilocarpine-induced limbic seizures." | 3.78 | Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation. ( Balasubramaniam, A; Clinckers, R; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2012) |
| "In this study, we investigated the role of GABAergic and glutamatergic systems in the anticonvulsant action of 3-alkynyl selenophene (3-ASP) in a pilocarpine (PC) model of seizures." | 3.78 | Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats. ( Bortolatto, CF; Gai, BM; Nogueira, CW; Roehrs, JA; Souza, AC; Wilhelm, EA, 2012) |
| "Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE)." | 3.78 | Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. ( Coimbra, Rde C; Fernandes, MJ; Massironi, SG; Mazzacoratti, Mda G; Nehlig, A; Neto, EF; Persike, DS; Silva, IR; Vignoli, T, 2012) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 3.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| " Here we explored the expression of synaptotagmin7 mRNA in the brains of rats with seizures triggered by the glutamatergic agonist kainate (10 mg/kg) or by the muscarinic agonist pilocarpine (30 mg/kg) in LiCl (3 mEq/kg) pre-treated (24 h) rats, in a time-course experiment (30 min-1 day)." | 3.78 | Differential patterns of synaptotagmin7 mRNA expression in rats with kainate- and pilocarpine-induced seizures. ( Glavan, G; See, RE; Živin, M, 2012) |
| " In the present work, we investigated whether pilocarpine-induced status epilepticus (SE) would alter Homer1a and mGluR5 expression in hippocampus." | 3.78 | Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. ( Blanco, MM; Cavarsan, CF; Mello, LE; Morais, RL; Motta, FL; Tescarollo, F; Tesone-Coelho, C, 2012) |
| " We found that inhibition of mTOR by rapamycin in immature rats (3-4 weeks old) increases the severity of seizures induced by pilocarpine, including lengthening the total seizure duration and reducing the latency to the onset of seizures." | 3.78 | Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. ( Huang, X; Huang, Y; McMahon, J; Shin, D; Yang, J, 2012) |
| "The present study investigated the effects of phytol in pilocarpine-induced seizures." | 3.78 | Anticonvulsant effect of phytol in a pilocarpine model in mice. ( Costa, JP; De Sousa, DP; Ferreira, PB; Freitas, RM; Jordan, J, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 3.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE)." | 3.78 | Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. ( Cui, XL; Jiang, W; Li, XW; Ma, L; Wang, Y; Wei, D; Yang, F, 2012) |
| "Status epilepticus (SE), a pro-epileptogenic brain insult in rodent models of temporal lobe epilepsy, is successfully induced by pilocarpine in some, but not all, rats." | 3.78 | Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats. ( Chen, MT; Hung, CP; Lin, YY; Shih, YH; Wang, CH, 2012) |
| "Pilocarpine-induced seizures induce an ectopic projection of hippocampal mossy fibers (MFs)." | 3.78 | Remodeling of hippocampal network in pilocarpine-treated mice expressing synaptopHluorin in the mossy fiber terminals. ( Ishizuka, T; Ito, S; Yawo, H, 2012) |
| "The effect of intraperitoneal administration of curcumin (30, 100, and 300 mg/kg) on pilocarpine-induced seizures in rats was tested." | 3.78 | Anticonvulsive and antioxidant effects of curcumin on pilocarpine-induced seizures in rats. ( DU, P; Fan, W; Li, X; Lin, HJ; Ma, Y; Peng, WF; Tang, HY; Wang, X, 2012) |
| " Additionally, the anticonvulsant profile of CBDV (50-200 mg·kg(-1) ) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats." | 3.78 | Cannabidivarin is anticonvulsant in mouse and rat. ( Duncan, M; Futamura, T; Glyn, SE; Hill, AJ; Hill, TD; Jones, NA; Mercier, MS; Stephens, GJ; Stott, CG; Whalley, BJ; Williams, CM; Yamasaki, Y, 2012) |
| " Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone (CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus." | 3.78 | Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy. ( Batie, M; Castro, OW; Danzer, SC; Garcia-Cairasco, N; Gardner, M; Herman, JP; Holland, KD; McKlveen, JM; Pun, RY; Santos, VR, 2012) |
| " In the study, one of the status epilepticus animal models of epilepsy was used, namely the model of temporal lobe epilepsy with pilocarpine-induced seizures." | 3.78 | Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study. ( Appel, K; Chwiej, J; Gzielo-Jurek, K; Janeczko, K; Kutorasinska, J; Setkowicz, Z; Simon, R; Uram, L, 2012) |
| "Pilocarpine injection induces epileptic seizures in rodents, an experimental paradigm extensively used to model temporal lobe epilepsy in humans." | 3.78 | Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. ( Barde, YA; Bischoff, V; Deogracias, R; Poirier, F, 2012) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1β (IL-1β) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures. ( de Freitas, RM; Gomes, KN; Saldanha, GB, 2011) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we describe a real time quantitative PCR (qPCR) approach to investigate relative changes in the expression of STREX and ZERO splice variants using a newly designed set of probes and primers for TaqMan-based qPCR analysis of cDNA from the rat dentate gyrus at different time points following pilocarpine-induced status epilepticus." | 3.77 | Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. ( Arshadmansab, MF; Ermolinsky, BS; Garcia, I; Garrido-Sanabria, ER; Otalora, LF; Skinner, F; Zarei, MM, 2011) |
| " The results obtained for rats with mechanical brain injuries were compared with those recorded for controls and animals with pilocarpine-induced seizures." | 3.77 | X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury. ( Appel, K; Chwiej, J; Janeczko, K; Sarapata, A; Setkowicz, Z; Stegowski, Z, 2011) |
| "STEP knockout mice were compared to wild-type (WT) mice in pilocarpine-induced seizures." | 3.77 | STEP regulation of seizure thresholds in the hippocampus. ( Aaron, G; Asik, K; Briggs, SW; Lombroso, P; Naegele, J; Walker, J, 2011) |
| "The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures." | 3.77 | Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. ( Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY, 2011) |
| " However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 3.77 | Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures. ( Chi, Z; Han, Y; Jiang, H; Lin, Y; Wang, S; Xie, N; Xu, J; Xue, Y, 2011) |
| " In this study, we investigated DZ attenuating neuronal loss caused by pilocarpine-induced seizures in rat hippocampus." | 3.77 | Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat. ( Cao, L; Chi, Z; Jiang, H; Xie, N; Xue, Y; Zhao, X, 2011) |
| "The effects of ALAC administered per os were evaluated by standard protocols against audiogenic seizures in Genetic Epilepsy Prone Rats (GEPR-9 rats), maximal electroshock (MES)-induced seizures in rats, pilocarpine-induced seizures in mice, spontaneous chronic seizures in mice exposed to pilocarpine-induced status epilepticus (SE), and absence seizures in WAG/Rij rats." | 3.77 | Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. ( Citraro, R; De Fazio, S; De Sarro, G; Mainardi, P; Perucca, E; Raggio, R; Russo, E; Scicchitano, F, 2011) |
| "Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes." | 3.77 | Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures. ( Campêlo, LM; Feitosa, CM; Freitas, RL; Freitas, RM; Saldanha, GB; Santos, PS, 2011) |
| "Pilocarpine was used to induce seizures in adult rats wild-type and perforin-deficient mice." | 3.77 | Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures. ( Cucullo, L; Fabene, PF; Ghosh, C; Janigro, D; Johnson, AJ; Johnson, HL; Marchi, N; Puvenna, V; Tierney, W, 2011) |
| "The present study has been designed to pharmacologically investigate the effect of Montelukast sodium, a leukotriene D(4) receptor antagonist, and 1,2,3,4, tetrahydroisoquinoline, a leukotriene D(4) synthetic pathway inhibitor, on the pathophysiological progression of seizures using mouse models of kindled epilepsy and status epilepticus induced spontaneous recurrent seizures." | 3.77 | Modulation of leukotriene D4 attenuates the development of seizures in mice. ( Rehni, AK; Singh, TG, 2011) |
| " The objective of the present study was to evaluate the neuroprotective effects of alpha-tocopherol in rats against oxidative stress caused by pilocarpine-induced seizures." | 3.77 | Oxidative stress in rat striatum after pilocarpine-induced seizures is diminished by alpha-tocopherol. ( Costa, JP; de Freitas, RM; de Souza, GF; dos Santos, PS; Feng, D; Saldanha, GB; Tomé, Ada R, 2011) |
| "Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy." | 3.77 | Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. ( Bajorat, R; Kirschstein, T; Köhling, R; Sellmann, T; Wilde, M, 2011) |
| " This "period without stimulus" was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150." | 3.77 | Early physical exercise and seizure susceptibility later in life. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Scorza, FA; Silva Araújo, BH, 2011) |
| " Prolonged seizures (status epilepticus, SE) were induced by pilocarpine." | 3.77 | Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus. ( Cardoso, A; Lukoyanov, NV; Lukoyanova, EA; Madeira, MD, 2011) |
| " Using C57BL/6J × A/J chromosome substitution strains (CSS), we previously identified a locus on mouse chromosome 10 (Ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic seizures and status epilepticus (status), followed by hippocampal cell loss and delayed-onset chronic spontaneous limbic seizures." | 3.77 | Mapping a mouse limbic seizure susceptibility locus on chromosome 10. ( Gildersleeve, SS; Palmer, AA; Phillips, AG; Rabinowitz, D; Winawer, MR, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 3.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| " The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice." | 3.77 | Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. ( Afrikanova, T; Clinckers, R; Crawford, AD; de Witte, PA; Esguerra, CV; Loyens, E; Massie, A; Michotte, Y; Schallier, A; Serruys, AS; Smolders, I; Vermoesen, K, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "Pilocarpine (PC), a muscarinic receptor agonist, is used for the induction of experimental models of status epilepticus (SE) for studying the type of seizure-induced brain injury and other neuropathophysiological mechanisms of related disorder." | 3.76 | The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. ( Chang, CN; Chang, SJ; Tsai, HL, 2010) |
| " Pilocarpine-induced seizures led to a robust, rapid, and transient increase in the primary transcript of miR-132 (pri-miR-132) followed by a subsequent rise in mature microRNA (miR-132)." | 3.76 | Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. ( DiRocco, DP; Garelick, MG; Lambert, TJ; Le, J; Nathanson, NM; Nudelman, AS; Storm, DR, 2010) |
| " To test this hypothesis, the anticonvulsant effect of a low dose of LPS against seizures elicited by pilocarpine hydrochloride was measured." | 3.76 | Behavioural and histological effects of preconditioning with lipopolysaccharide in epileptic rats. ( Cybulska, R; Dmowska, M; Gawron, A; Jaworska-Adamu, J; Piersiak, T; Schoenborn, R, 2010) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "Using the epilepsy model obtained by systemic administration of pilocarpine in rats in the present study we investigated the changes caused by seizures on content and species of gangliosides and phospholipids, as well as on cholesterol concentration, glutathione reduced contents, Na(+), K(+)-ATPase activity and lipid peroxidation levels in rat hippocampus." | 3.76 | Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures. ( de Freitas, RM; do Nascimento, KG; Ferreira, PM; Jordán, J, 2010) |
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 3.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "In the present study we investigated the alterations on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in rat striatum and frontal cortex caused by pilocarpine-induced seizures." | 3.76 | Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures. ( Freitas, RL; Freitas, RM; Saldanha, GB; Sales, IM; Souza, GF, 2010) |
| " It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress." | 3.76 | The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Tomé, AR, 2010) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 3.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| "In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine." | 3.76 | Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. ( de Freitas, RM; de Souza, GF; Feitosa, CM; Feng, D; Jordán, J; Santos, IM; Tomé, Ada R, 2010) |
| " SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14." | 3.76 | Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. ( Aourz, N; Clinckers, R; De Bundel, D; Hoyer, D; Kastellakis, A; Kiagiadaki, F; Michotte, Y; Smolders, I; Thermos, K, 2010) |
| ")-injected GLP-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat." | 3.76 | Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat. ( Gulec, G; Isbil-Buyukcoskun, N; Kahveci, N, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 3.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| "Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring." | 3.76 | Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Jordán, J, 2010) |
| " An epilepsy model was induced in female rats by administration of pilocarpine." | 3.76 | Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures. ( Amado, D; Arganãraz, GA; Cavalheiro, EA; Frussa-Filho, R; Lima, DC; Naffah-Mazzacoratti, Mda G; Vale, TG; Varella, PP, 2010) |
| " Since this balance is interrupted in epileptic seizures, we explored whether LiCl/pilocarpine- or kainate-induced epileptic seizures would induce changes in the levels of Nova mRNAs in the rat brain." | 3.76 | Cholinergic regulation of striatal Nova mRNAs. ( Jelen, N; Ule, J; Zivin, M, 2010) |
| "To examine the expression of IL-1beta, IL-1ra and IL-1R mRNA in the dentate gyrus of adult rats after lithium-pilocarpine (Li-PILO)-induced seizures." | 3.76 | [Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures]. ( Jiang, W; Li, XW; Wang, Y; Wei, D; Zhang, SJ, 2010) |
| " In the rat Li-pilocarpine status epilepticus model, CYM2503, injected intraperitoneally, increased the latency to first electrographic seizure and the latency to first stage 3 behavioral seizure, decreased the latency to the establishment of status epilepticus, and dramatically decreased the mortality." | 3.76 | GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. ( Baldwin, R; Bartfai, T; Chang, J; Liu, T; Lu, X; Roberts, E; Sanchez-Alavez, M; Wasterlain, CG; Wu, S; Xia, F, 2010) |
| "We analyzed with EEG-video monitoring the epileptic activity recorded during the latent and chronic periods in rats undergoing 30 or 120 min pilocarpine-induced convulsive status epilepticus (SE)." | 3.76 | Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system. ( Avoli, M; Biagini, G; Bortel, A; Gotman, J; Lévesque, M, 2010) |
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| " The anticonvulsant activity of American skullcap was determined in rat models of acute seizures induced by pilocarpine and pentylenetetrazol." | 3.75 | Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora). ( Li, S; Lian, XY; Stringer, JL; Zhang, Z, 2009) |
| "Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)." | 3.75 | Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 3.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| " We sought to determine which cells express P450cc and whether neurosteroids play a role in the regulation of epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.75 | Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period. ( Avoli, M; Baldelli, E; Bertazzoni, G; Biagini, G; Longo, D; Rogawski, MA; Zoli, M, 2009) |
| "To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy." | 3.75 | Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. ( Ballester, G; Bonilha, SM; Covolan, L; Ewerton, FI; Fantin Cavarsan, C; Hamani, C; Lozano, AM; Marcolin de Almeida, F; Mello, LE, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 3.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| "It has been suggested that pilocarpine-induced seizures is mediated by increases in oxidative stress." | 3.75 | The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures. ( Freitas, RM, 2009) |
| " However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 3.75 | Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. ( Cao, L; Chi, Z; Lin, Y; Wang, R; Wang, S; Xu, J, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 3.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| " In the rat pilocarpine model, status epilepticus significantly increased P-glycoprotein expression by 92 to 197% in the hippocampal hilus and granule cell layer as well as the piriform cortex." | 3.75 | Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. ( Bauer, B; Gorter, JA; Hartz, AM; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Unkrüer, B; van Vliet, EA, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 3.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 3.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 3.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection." | 3.75 | Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. ( Arisi, GM; Foresti, ML; Katki, K; Montañez, A; Sanchez, RM; Shapiro, LA, 2009) |
| "Recent evidence suggests that amiloride, a potent and nonselective blocker of acid-sensing ion channels, suppresses generalized seizures induced by maximal electroshock and pentylenetrazole." | 3.74 | Amiloride delays the onset of pilocarpine-induced seizures in rats. ( N'Gouemo, P, 2008) |
| "BmK IT2 showed anticonvulsant activity as it inhibited the widespread seizures induced by PTZ and pilocarpine-induced SE in rats." | 3.74 | Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy. ( Ji, YH; Jiang, LL; Shu, XQ; Weng, CC; Yang, J; Zhang, JW; Zhang, XY; Zhao, R, 2008) |
| " Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus." | 3.74 | Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| " Proneurotrophins, which are potent apoptosis-inducing ligands for p75(NTR), were increased in the hippocampus, particularly in astrocytes, by pilocarpine-induced seizures; and infusion of anti-pro-NGF dramatically attenuated neuronal loss after seizures." | 3.74 | Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. ( Carter, BD; Cragnolini, A; Friedman, WJ; Hempstead, BL; Kenchappa, RS; Light, M; Trotter, C; Volosin, M, 2008) |
| "The present study was designed to examine whether neuroprotective agents, FK506 or cyclosporin A (CsA), applied to rats undergoing pilocarpine-induced seizures can minimize further development of the status epilepticus." | 3.74 | Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures. ( Ciarach, M; Setkowicz, Z, 2007) |
| " Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy." | 3.74 | Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures. ( Aguiar, LM; Almeida, JP; Fonseca, FN; Fonteles, MM; Freitas, RM; Júnior, HV; Nascimento, VS; Oliveira, AA; Sousa, FC; Viana, GS, 2007) |
| " QTLs for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not been reported, and CSS have not previously been used to localize seizure susceptibility genes." | 3.74 | Use of chromosome substitution strains to identify seizure susceptibility loci in mice. ( Guell, IP; Kuperman, R; Niethammer, M; Palmer, AA; Ponder, CA; Rabinowitz, D; Sherman, S; Winawer, MR, 2007) |
| ") injection of L-NAME (a nitric oxide synthase inhibitor) or CaEDTA (an extracellular zinc chelator) or the combination of the two could affect the initial phase of pilocarpine induced (2 h) seizures." | 3.74 | The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures. ( Danscher, G; Jensen, MS; Noyan, B, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 3.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybutyrate lactone (GBL)-induced absence seizure model." | 3.74 | Anti-glutamatergic effect of riluzole: comparison with valproic acid. ( Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK, 2007) |
| " Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats." | 3.74 | Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine. ( Barbosa, CO; Barros, DO; Freitas, RM; Oliveira, AA; Silva, RF; Xavier, SM, 2007) |
| " This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model." | 3.74 | Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats. ( Belmaker, RH; Einat, H; Frost, JW; Tian, F, 2008) |
| " Postnatal day 7 (P7) and P14 rat pups were injected with an exogenous provocative agent of inflammation, lipopolysaccharide (LPS), 2 h prior to limbic SE induced by either lithium-pilocarpine (LiPC) or kainic acid." | 3.74 | Inflammation exacerbates seizure-induced injury in the immature brain. ( Auvin, S; Mazarati, A; Miyamoto, J; Nakagawa, J; Sankar, R; Shin, D, 2007) |
| " The anticonvulsant activity of F1,6BP was determined in rat models of acute seizures induced by pilocarpine, kainic acid, or pentylenetetrazole." | 3.74 | Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. ( Khan, FA; Lian, XY; Stringer, JL, 2007) |
| " Because a linear relationship does not always exist between expression of mRNA and protein, we investigated whether VEGF protein expression increased after pilocarpine-induced status epilepticus." | 3.74 | Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. ( Atassi, H; Croll, SD; Elkady, A; Goodman, JH; Hylton, D; McCloskey, DP; Nicoletti, JN; Rudge, JS; Scharfman, HE; Shah, SK, 2008) |
| "The anticonvulsant effects of AN stimulation against pilocarpine-induced seizures were mainly determined by the current and not the frequency of stimulation." | 3.74 | Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. ( Andrade, DM; Chiang, J; del Campo, M; Hamani, C; Hodaie, M; Lozano, AM; Mello, LE; Mirski, M; Sherman, D, 2008) |
| "In the present study, we examined the neuroprotective effects of vitamin C in adult rats after pilocarpine-induced seizures." | 3.74 | Neuroprotective actions of vitamin C related to decreased lipid peroxidation and increased catalase activity in adult rats after pilocarpine-induced seizures. ( Freitas, RL; Freitas, RM; Saldanha, GB; Santos, LF; Xavier, SM, 2008) |
| " They behaved similarly to lithium-treated animals in the model of pilocarpine seizures and in the Porsolt forced swimming test model of depression." | 3.74 | Homozygote inositol transporter knockout mice show a lithium-like phenotype. ( Agam, G; Belmaker, RH; Berry, GT; Bersudsky, Y; Shaldubina, A, 2008) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| " The rat lithium-pilocarpine model, which mimics many features of temporal lobe epilepsy, has been used to study processes leading to the development of recurrent seizures." | 3.74 | The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model. ( Brown, IR; Lively, S, 2008) |
| "One hour after treatment with normal saline, or one of the three ginseng preparations, seizures were induced in adult, male, Sprague-Dawley rats with kainic acid (KA; 10 mg/kg), pilocarpine (300 mg/kg, preceded by methylscopolamine, 1 mg/kg, s." | 3.73 | Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. ( Lian, XY; Stringer, JL; Zhang, ZZ, 2005) |
| " Seizures were induced by pilocarpine (400 mg/kg; i." | 3.73 | Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat. ( Basta-Kaim, A; Budziszewska, B; Dziedzicka-Wasylewska, M; Jaworska-Feil, L; Kubera, M; Kuśmider, M; Kutner, A; Lasoń, W; Leśkiewicz, M; Myint, AM; Skowroński, M; Tetich, M, 2005) |
| " More precisely, the influence of intrahippocampal perfusion of verapamil, a P-glycoprotein inhibitor, and probenecid, a multidrug resistance protein inhibitor, on the blood-brain barrier passage and anticonvulsant properties of oxcarbazepine were investigated in the focal pilocarpine model for limbic seizures." | 3.73 | Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2005) |
| "Although the presence of profound cognitive disturbances in lithium-pilocarpine-induced spontaneous recurrent seizures (SRS) has been well documented, much less is known about changes in emotional behavior, in this model of temporal lobe epilepsy." | 3.73 | Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures. ( Bidziński, A; Lechowicz, W; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Turzyńska, D; Walkowiak, J; Wierzba-Bobrowicz, T, 2005) |
| "To extend previous work concerning diet and overt seizures in rats, we tested the hypothesis that ingestion of 10% sucrose-water could reduce seizure onset time (SOT) in rats given lithium and pilocarpine." | 3.73 | Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine. ( Galic, MA; Persinger, MA, 2005) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 3.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| " We tested this hypothesis by repeatedly assessing granule cell excitability after pilocarpine-induced status epilepticus (SE) and monitoring granule cell behavior during 235 spontaneous seizures in awake, chronically implanted rats." | 3.73 | Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis. ( Harvey, BD; Sloviter, RS, 2005) |
| "We describe the use of a clinically relevant pharmacological intervention that alters the clinical history of status epilepticus (SE)-induced spontaneous recurrent seizures (SRS) in the pilocarpine model and the possible plastic changes underlying such an effect." | 3.73 | Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats. ( Benassi, SK; Mello, LE; Pereira, HA, 2005) |
| "Seizures were induced in female Wistar albino rats at either 35 or 55 days of age with a single systemic injection of lithium (3 mEq/kg) and pilocarpine (30 mg/kg); the rats were then treated with the atypical neuroleptic acepromazine (25 mg/kg)." | 3.73 | Extreme obesity in female rats following prepuberal induction of lithium-pilocarpine seizures and a single injection of acepromazine. ( Persinger, MA; St-Pierre, LS, 2005) |
| " Its antiepileptic properties have been proved in various animal models, including pilocarpine-induced seizures in adult rats." | 3.73 | Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. ( D'alva, MS; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Sousa, FC; Vasconcelos, SM, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " Thresholds for producing seizures in brain-derived neurotrophic factor wild-type and brain-derived neurotrophic factor heterozygous mice were compared in several seizure models, including thresholds for electrically-induced clonic, tonic-clonic and 6 Hz limbic seizures, as well as seizures induced chemically by kainate, pilocarpine and pentylenetetrazol." | 3.73 | The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. ( Barton, ME; Shannon, HE, 2005) |
| " Furthermore, we examined whether the MRP2 protein is overexpressed after experimentally induced seizures in rats, using the pilocarpine model of temporal lobe epilepsy." | 3.73 | Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. ( Gastens, AM; Hoffmann, K; Löscher, W; Volk, HA, 2006) |
| "We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1." | 3.73 | Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure. ( Gordon, RK; Nambiar, MP; Ratcliffe, RH; Rezk, PE; Steele, KE; Tetz, LM, 2006) |
| "0 mg/kg) as well as increasing the threshold to electrically- and pentylenetetrazole-induced seizures (TID(10)s 7." | 3.73 | In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. ( Anderson, NJ; Slough, S; Watson, WP, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.73 | Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2006) |
| " This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures." | 3.72 | N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities. ( Tan, CY; Wainman, D; Weaver, DF, 2003) |
| "This work evaluates the seizure susceptibility of nai;ve female Wistar Audiogenic rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), to other pro-convulsive stimuli: transauricular electroshock (ES), pentylenetetrazole (PTZ) and pilocarpine (PILO)." | 3.72 | Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine. ( Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV, 2003) |
| "In the pilocarpine model of chronic limbic seizures, vulnerability of GABAergic interneurons to excitotoxic damage has been reported in the hippocampal CA1 region." | 3.72 | Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures. ( Ben-Ari, Y; Dinocourt, C; Esclapez, M; Freund, TF; Petanjek, Z, 2003) |
| " The muscarinic agonist oxotremorine induced marked hypothermia in all the knockout mice, but the hypothermia was reduced in M2 and to a lesser extent in M3 knockout mice." | 3.72 | Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. ( Bymaster, FP; Carter, PA; Felder, CC; Gomeza, J; Hamilton, SE; McKinzie, DL; Nathanson, NM; Wess, J; Yamada, M, 2003) |
| " Most animals present seizures at rest rather than during exercise and LCMRglu was measured during the interictal phase of the chronic period of a pilocarpine model of epilepsy by the [14C]2-deoxyglucose (2DG) method." | 3.72 | Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy. ( Arida, RM; Cavalheiro, EA; Fernandes, MJ; Preti, SC; Scorza, FA, 2003) |
| " The doses increased the latency time to convulsions induced by picrotoxin and pilocarpine but prevented the onset of pentylenotetrazol and strychnine induced seizures." | 3.72 | Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L. ( Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL, 2003) |
| "To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine." | 3.72 | Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development. ( Janeczko, K; Kłak, K; Setkowicz, Z, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 3.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| " Intrahippocampal mGluR group I agonist perfusion via a microdialysis probe [1 mm (R,S)-3,5-dihydroxyphenylglycine] induced seizures and concomitant augmentations in amino acid dialysate levels." | 3.72 | In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. ( Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I, 2004) |
| " The anticonvulsant effects of intrahippocampally applied DA and 5-HT concentrations were evaluated against pilocarpine-induced seizures in conscious rats." | 3.72 | Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 3.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "We used pilocarpine-induced seizures in mice to determine the impact of genetic background on the vulnerability of hippocampal neurons and associated changes of behavioral performance." | 3.72 | The impact of genetic background on neurodegeneration and behavior in seizured mice. ( Lipp, HP; Madani, R; Mohajeri, MH; Nitsch, RM; Saini, K; Wolfer, DP, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 3.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " BDNF mRNA and protein accumulate in dendrites in all hippocampal subfields after pilocarpine seizures and in selected subfields after other epileptogenic stimuli (kainate and kindling)." | 3.72 | Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. ( Armellin, M; Bregola, G; Cattaneo, A; Giulianini, PG; Paradiso, B; Simonato, M; Steward, O; Tongiorgi, E; Zucchini, S, 2004) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 3.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| " In this study, immature rats were exposed to status epilepticus (SE) followed by a series of 25 flurothyl-induced seizures, SE alone, 25 flurothyl-induced seizures alone, or no seizures." | 3.72 | Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis". ( Hoffmann, AF; Holmes, GL; Zhao, Q, 2004) |
| "To analyze whether the subcellular localization of the messenger RNAs (mRNAs) coding for the neurotrophin brain-derived neurotrophic factor (BDNF), its receptor TrkB, and the alpha and beta subunits of calcium-calmodulin-dependent kinase II (CaMKII) are modified after pilocarpine and kindled seizures." | 3.71 | Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy. ( Armellin, M; Bregola, G; Del Piccolo, P; Rodi, D; Simonato, M; Tongiorgi, E; Zucchini, S, 2002) |
| " We determined whether caspase-3 is activated by lithium-pilocarpine-induced status epilepticus in six brain regions with necrosis-induced DNA laddering." | 3.71 | Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage. ( Fujikawa, DG; Ke, X; Shinmei, SS; Trinidad, RB; Wu, A, 2002) |
| " beta2(-/-) mice displayed increased susceptibility to seizures, as indicated by reduced latency and threshold for pilocarpine-induced seizures, but seemed normal in other neurological tests." | 3.71 | Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. ( Avery, C; Bharucha, V; Brown, A; Catterall, WA; Chen, C; Chen, Y; Gillespie, PJ; Isom, LL; Jones, D; Kazarinova-Noyes, K; Kazen-Gillespie, KA; Macdonald, RL; Malhotra, JD; Ransom, BR; Saunders, TL; Scheuer, T; Shrager, P; Westenbroek, RE, 2002) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 3.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 3.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| "The efficacy of the cholinergic agonist pilocarpine to evoke generalized seizures in rats was examined over the 24-h photocycle." | 3.71 | Diurnal variation in pilocarpine-induced generalized tonic-clonic seizure activity. ( Leung, LS; Persinger, MA; Stewart, LS, 2001) |
| " We show here that another form of status epilepticus, induced by administration of the muscarinic agonist pilocarpine, produces changes in zinc that are essentially the same as those produced by the kainic acid-induced seizures." | 3.71 | Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. ( Frederickson, CJ; Suh, SW; Thompson, RB, 2001) |
| " These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory." | 3.71 | Alteration of cardiovascular and neuronal function in M1 knockout mice. ( Anagnostaras, SG; Feigl, EO; Hamilton, SE; Hardouin, SN; Murphy, GG; Nathanson, NM; Richmond, KN; Silva, AJ, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 3.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 3.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 3.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " To address this issue further, we asked whether the new hilar granule cells were active during spontaneous limbic seizures that follow status epilepticus induced by pilocarpine injection." | 3.71 | Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| ") also potentiates oxotremorine-induced tremors in mice, in a dose-dependent manner, and this effect was completely prevented by atropine." | 3.71 | Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. ( Cunha, GM; Farias, PA; Viana, GS, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 3.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| "Glucose utilization of four cerebral cortex and 35 subcortical regions (CGU) was analyzed in three models of cholinergic seizures induced by the following compounds: 1) soman (pinacolylmethylphosphonofluoridate) an organophosphorus cholinesterase inhibitor, 100 microg/kg SC after pretreatment with pyridostigmine 26 microg/kg IM (n = 6); 2) physostigmine, a carbamate cholinesterase inhibitor, 1." | 3.70 | Mapping of cerebral metabolic activation in three models of cholinergic convulsions. ( Jenden, DJ; Li, MG; Scremin, OU; Shih, TM, 1998) |
| "The effects of kappa opioids on seizures and seizure-induced histopathology were investigated with the pilocarpine model of temporal lobe epilepsy." | 3.70 | Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology. ( Bausch, SB; Chavkin, C; Esteb, TM; Terman, GW, 1998) |
| " To test this hypothesis, the present study evaluates the effects of two inositol uptake inhibitors, the carbohydrate L-fucose and the cyclodepsipeptide nordidemnin, in a behavioral model of pilocarpine-induced seizures known to be enhanced by lithium." | 3.70 | Augmentation of lithium's behavioral effect by inositol uptake inhibitors. ( Belmaker, RH; Einat, H; Itkin, O; Kofman, O; Lewitan, RJ, 1998) |
| "Time-dependent atrophy of cerebral space and enlargement of the lateral ventricles were noted in healthy rats 1 to 100 days after the induction of seizures by a single systemic injection of lithium and pilocarpine." | 3.70 | Ventricular dilation over several weeks following induction of excitotoxic (systemic lithium/pilocarpine) lesions: potential role of damage to the substantia nigra reticulata. ( Desjardins, D; Eastman, A; Peredery, O; Persinger, MA, 1998) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 3.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 3.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| "The expression of mRNA coding for prepro-thyrotropin releasing hormone (preproTRH) was estimated in the rat brain in two animal models of limbic seizures, evoked by systemic administration of pilocarpine (400 mg/kg ip) or kainate (12 mg/kg ip)." | 3.70 | Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain. ( Budziszewska, B; Jaworska-Feil, L; Lasoń, W; Leśkiewicz, M; Przewłocka, B; Turchan, J, 1999) |
| "Rats treated with the NMDA-blocker, ketamine hydrochloride 30 minutes after the induction of seizures by lithium pilocarpine exhibited statistically smaller lateral ventricles in the left hemisphere compared to rats that had received acepromazine after the induction of these seizures." | 3.70 | Ventricular enlargement and the lithium/pilocarpine seizure model: possible explanation for agonistic behaviour. ( Cook, LL, 2000) |
| "In a recent report we have shown that a protein synthesis inhibitor, cycloheximide (CHX), is able to block the mossy fiber sprouting (MFS) that would otherwise be triggered by pilocarpine (Pilo)-induced status epilepticus (SE), and also gives relative protection against hippocampal neuronal death." | 3.70 | Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting. ( Longo, BM; Mello, LE, 1999) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| " We have compared the acute effects of PBN on the development of seizures induced by the irreversible acetylcholinesterase (AChE) inhibitor diisopropylphosphorofluoridate (DFP), the reversible AChE inhibitor physostigmine (PHY), the muscarinic cholinergic receptor agonist pilocarpine (PIL) and the glutamatergic receptor agonist kainic acid (KA)." | 3.70 | Nitrone spin trapping compound N-tert-butyl-alpha-phenylnitrone prevents seizures induced by anticholinesterases. ( Dettbarn, WD; Milatovic, D; Zivin, M, 1999) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 3.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "The present microdialysis study was aimed at evaluating the anticonvulsant effect of the adenosine A(1) receptor agonist 2-chloroadenosine (2-CADO) against pilocarpine-induced seizures in rats." | 3.70 | Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 3.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "Estimates of neuronal dropout for approximately 100 structures as defined by Paxinos-Watson were completed for brains of male Wistar albino rats between 1 and 50 days after status epilepticus was evoked by a single systemic injection of lithium and pilocarpine." | 3.70 | Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat. ( Mastrosov, L; Parker, G; Peredery, O; Persinger, MA, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 3.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| ") produced a prompt anticonvulsant effect in pilocarpine-induced seizures in freely moving rats." | 3.70 | Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2000) |
| " We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation." | 3.69 | Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. ( Barbier, P; Corsini, GU; Donati, E; Fumagalli, F; Maggio, R; Racagni, G; Riva, M, 1995) |
| " Limbic seizures were induced by a single systemic injection of lithium and pilocarpine when the rats were adults." | 3.69 | Early genital stimulation of rats lowers limbic seizure latencies for females but increases latencies for males. ( Baker, P; Persinger, MA, 1995) |
| "A decrease in the latency for the overt display of limbic seizures following the systemic injection of lithium and pilocarpine is weakly associated with enhanced global geomagnetic activity (in nanoTesla; nT)." | 3.69 | Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla. ( Bureau, YR; Persinger, MA, 1995) |
| "Pilocarpine (PILO) induces in rats limbic seizures that become secondarily generalized and evolve to status epilepticus (SE)." | 3.69 | Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. ( Cavalheiro, EA; Leite, JP, 1995) |
| " It had previously been shown that pilocarpine causes a limbic seizure syndrome in lithium treated rats, and that these lithium-pilocarpine seizures are reversible by intracerebroventricular inositol administration to rats." | 3.69 | High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium. ( Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Shapiro, Y, 1994) |
| "Involvement of the kappa opioid receptor in regulation of the pilocarpine-induced seizures and neurodegeneration was studied in mice." | 3.69 | Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse. ( Lasoń, W; Machelska, H; Przewłocka, B, 1994) |
| "The biologically active enantiomer (CGP 40116) of the new competitive N-methyl-D-aspartate (NMDA) receptor antagonist CGP 37849 was investigated for its effects on pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse." | 3.69 | The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse. ( Starr, BS; Starr, MS, 1994) |
| "The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats." | 3.69 | Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| " To determine if these D3 receptors were capable of attenuating limbic motor seizures induced by pilocarpine, dopamine agonists with preferential or non-selective D3 affinity were injected stereotaxically into these limbic brain regions of the rat via indwelling cannulae prior to pilocarpine challenge." | 3.69 | Effects of dopamine D3 receptor agonists on pilocarpine-induced limbic seizures in the rat. ( Alam, AM; Starr, MS, 1994) |
| "Multivariate analyses between conditioned taste aversion (CTA) and radial maze acquisition (RMA) scores and percentages of neuronal dropout within thalamic and telencephalic structures were completed for rats in which overt seizures had been evoked following a single systemic injection of lithium/pilocarpine." | 3.69 | Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 3.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| " Lithium pretreatment potentiated IEG expression induced by 30 mg/kg pilocarpine, likely as a result of the seizures caused by this combination of drugs because pretreatment with anticonvulsants (diazepam or MK-801) blocked seizures and the enhanced IEG mRNA levels." | 3.69 | Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Adult male albino rats were given a treatment that produced hypothermia after the induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 3.69 | Maintained hypersexuality between male rats following chronically induced limbic seizures: implications for bisexuality in complex partial epileptic seizures. ( Persinger, MA, 1994) |
| "Aggressive behaviors (numbers of bites/hour) within groups (ns = 8) of normal rats and rats in which seizures had been induced by a single systemic injection of lithium/pilocarpine were observed for 11 successive, 1-hr, periods." | 3.69 | Association between intermale social aggression and cellular density within the central amygdaloid nucleus in rats with lithium/pilocarpine-induced seizures. ( Desjardins, D; Persinger, MA, 1995) |
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 3.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 3.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| "The effect of the nitric oxide synthase (NOS) inhibitors N-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI) on seizures induced by N-methyl-D-aspartate (NMDA), pilocarpine (PIL) and pentylenetetrazol (PTZ), as well as on the electroconvulsive threshold was studied in mice." | 3.69 | The role of nitric oxide in chemically- and electrically-induced seizures in mice. ( Baran, L; Przegaliñski, E; Siwanowicz, J, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| " To understand better the potential role played by prohormone convertases in the central nervous system we studied the expression of their messenger RNAs in the hippocampus of rats with pilocarpine-induced seizures." | 3.69 | Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression. ( Avoli, M; Chrétien, M; Day, R; Marcinkiewicz, M; Nagao, T; Seidah, NG, 1997) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 3.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 3.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "The effects of pilocarpine- and kainate-induced seizures on N-methyl-D-aspartate receptor subunit-1 messenger RNA and [3H]dizocilpine maleate binding were studied in the rat hippocampal formation." | 3.69 | Effects of pilocarpine and kainate-induced seizures on N-methyl-D-aspartate receptor gene expression in the rat hippocampus. ( Labuz, D; Lasón, W; Machelska, H; Przewłocka, B; Przewłocki, R; Turchan, J, 1997) |
| "The expression of mRNA coding for AMPA selective glutamate (Glu) R2 receptor and kainate selective GluR5 receptor was studied in the rat hippocampal formation in two animal models of limbic seizures evoked by systemic administration of pilocarpine (400 mg/kg i." | 3.69 | Seizure-related changes in the glutamate R2 and R5 receptor genes expression in the rat hippocampal formation. ( Labuz, D; Lasoń, W; Mika, J; Przewłocka, B; Przewłocki, R; Turchan, J, 1997) |
| " Significant elevations of extracellular glutamate were observed following seizures induced by either kainic acid or pilocarpine." | 3.69 | Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study. ( Holmes, GL; Hori, A; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 1997) |
| " Pilocarpine administration has been used as an animal model for temporal lobe epilepsy since it produces several morphological and synaptic features in common with human complex partial seizures." | 3.69 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "Flinch (pain) thresholds for electric current delivered to the feet were correlated with the amount of necrosis within the diencephalon and telencephalon for rats in which seizures had been induced by lithium and pilocarpine about two months before the testing." | 3.69 | Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats. ( Bureau, YR; Cook, LL; Peredery, O; Persinger, MA, 1997) |
| " In addition, both homozygous and heterozygous mutant mice are highly resistant to the seizures produced by systemic administration of the muscarinic agonist pilocarpine." | 3.69 | Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. ( Hamilton, SE; Hille, B; Idzerda, RL; Levey, AI; Loose, MD; McKnight, GS; Nathanson, NM; Qi, M, 1997) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 3.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 3.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "Clozapine and haloperidol were tested for their ability to influence the acquisition of kindled seizures following electrical stimulation of the amygdala and ventral hippocampus." | 3.68 | Clozapine inhibits limbic system kindling: implications for antipsychotic action. ( Graham, SR; Kokkinidis, L, 1993) |
| "A range of D1 receptor agonists were tested for their ability to facilitate limbic motor seizures induced by a subthreshold dose of the chemoconvulsant pilocarpine (100 mg/kg IP) in mice." | 3.68 | Seizure promotion by D1 agonists does not correlate with other dopaminergic properties. ( Starr, BS; Starr, MS, 1993) |
| "The sensitivity of pilocarpine-induced seizures to NMDA receptor blockade with MK-801, or to inhibition of synthesis of the second messenger nitric oxide (NO) with N omega-nitro-L-arginine methyl ester (L-NAME), was studied in mice." | 3.68 | Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME. ( Starr, BS; Starr, MS, 1993) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 3.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| " Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus." | 3.68 | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 3.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| " Therefore, the concentrations of three second messengers, inositol 1,4,5 trisphosphate (Ins 1,4,5P3), cyclic adenosine monophosphate (AMP), and cyclic guanosine monophosphate (GMP), were measured in rat cerebral cortex and hippocampus after acute or chronic lithium administration, as well as after treatment with the cholinergic agonist pilocarpine alone or in combination with lithium at a dose that induces seizures only in lithium pretreated rats." | 3.68 | Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. ( Jope, RS; Kolasa, K; Song, L, 1992) |
| "Between 30 and 50 days after the induction of seizures by a single injection of lithium and pilocarpine, large aggregates of Nissl-staining material appeared; they occupied up to 35% of the thalamic volume." | 3.68 | Progressive accumulation of large aggregates of calcium-containing polysaccharides and basophilic debris within specific thalamic nuclei after lithium/pilocarpine-induced seizures. ( Lafreniere, GF; Peredery, O; Persinger, MA, 1992) |
| " The object of this study was to determine the effect of SCC on behavioral and EEG symptomatology in the lithium-pilocarpine model of seizures and status epilepticus in the rat." | 3.68 | Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus. ( Gilles, F; Hirsch, E; Snead, OC; Vergnes, M, 1992) |
| "The present study addressed the role of dopamine D1 receptors in pilocarpine-induced motor seizures in rats." | 3.68 | Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors. ( Alam, AM; Starr, MS, 1992) |
| " Similarly, following pretreatment with intranigral isoniazid, neither severity nor latency to onset of seizures elicited by systemic injection of kainic acid (9 mg/kg) were modified." | 3.68 | Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. ( Gale, K; Maggio, R; Sohn, E, 1991) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 3.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| "In the pilocarpine model of epilepsy, dopamine can either inhibit (via D2 receptors) or facilitate (via D1 receptors) the spread of limbic motor seizures." | 3.68 | Anticonvulsant effect of striatal dopamine D2 receptor stimulation: dependence on cortical circuits? ( al-Tajir, G; Starr, MS, 1991) |
| " The seizures, which induce insidious brain damage within a multitude of diencephalic and subcortical telencephalic structures, were induced by a single injection of lithium (3 mEq/kg sc) followed 24 hr later by pilocarpine (30 mg/kg sc)." | 3.68 | Radial maze learning deficits and mediodorsal thalamic damage in context of multifocal seizure-induced brain lesions. ( Harrigan, T; Peredery, O; Persinger, M, 1991) |
| "Previous studies with lithium have shown that it potentiated the in vivo response to cholinomimetics in rats, resulting in seizures at otherwise non-convulsant doses, but did not affect seizure activity induced by a number of chemical convulsants including kainic acid and N-methyl-D-aspartate (NMDA)." | 3.68 | Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate. ( Jope, RS; Ormandy, GC, 1991) |
| "This study investigates the role of forebrain D1 receptors in the motor expression of seizures induced by pilocarpine." | 3.68 | Anticonvulsant action of SCH 23390 in the striatum of the rat. ( al-Tajir, G; Starr, MS, 1990) |
| " In contrast, bilateral microinjection of BMI into the rat striatum confers protection against seizures induced by the cholinergic agonist pilocarpine (380 mg/kg, i." | 3.68 | Paradoxical anticonvulsant activity of the gamma-aminobutyrate antagonist bicuculline methiodide in the rat striatum. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Diedrichs, S; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA, 1991) |
| "In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus." | 3.68 | GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures. ( Cavalheiro, EA, 1990) |
| " This work presents evidence that bilateral microinjection of the DAD1 agonist SKF-38393 into the substantia nigra enhances the susceptibility of rats to seizures, with an ED50 of 20 pmol (range 13-31 pmol), converting subconvulsant doses of the cholinergic agonist pilocarpine (200 mg/kg; i." | 3.68 | Dopamine control of seizure propagation: intranigral dopamine D1 agonist SKF-38393 enhances susceptibility to seizures. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Klockgether, T; Turski, L; Turski, WA, 1990) |
| "The cholinergic agonist pilocarpine triggers sustained limbic seizures in rodents." | 3.68 | Substantia nigra regulates action of antiepileptic drugs. ( Andrews, JS; Bortolotto, ZA; Bressler, K; Calderazzo-Filho, LS; Cavalheiro, EA; Löschmann, PA; Turski, L, 1990) |
| "Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents." | 3.68 | Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Leite, JP, 1990) |
| "Focal, limbic seizures were produced by systemically administered pilocarpine (200 mg/kg, i." | 3.67 | D-1 dopamine agonist administration reduces the threshold for convulsions produced by pilocarpine. ( Barone, P; Campanella, G; Chase, TN; Marin, C; Palma, V; Parashos, SA, 1989) |
| "The prepiriform cortex (PPCx) shows high sensitivity to the epileptogenic action of chemo-convulsants and to the protective action of the NMDA receptor antagonist, 2-amino-7-phosphono-heptanoate (APH) against pilocarpine-induced (motor) limbic seizures in rats." | 3.67 | The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "The characteristics and consequences of limbic seizures evoked by single peripheral injections of lithium (3 mEq/kg) and pilocarpine (30 mg/kg) were investigated over a three-year period." | 3.67 | Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. ( Bradley, JC; Makarec, K; Persinger, MA, 1988) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 3.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Seizures produced by pilocarpine given i." | 3.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "The participation of excitatory neurotransmitter systems in the basal ganglia in the initiation and propagation of limbic seizures induced by pilocarpine has been investigated in the rat." | 3.67 | Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats. ( De Sarro, GB; Meldrum, BS; Patel, S, 1988) |
| "Microinjection of muscimol (406 pmol) into the rat entopeduncular nucleus, the analogue of the primate globus pallidus pars interna, significantly suppressed pilocarpine but not maximal electroshock seizures in a spatially specific manner." | 3.67 | Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats. ( Hosford, DA; McNamara, JO, 1988) |
| "The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain." | 3.67 | Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou-Turski, C; Kleinrok, Z; Turski, L; Turski, WA, 1988) |
| "Limbic seizures were evoked in rats by single subcutaneous injections of lithium and pilocarpine that are known to elicit severe damage to gustatory-affective centers in the brain." | 3.67 | Conditioned taste aversion is reduced in rats with a history of lithium/pilocarpine-induced limbic seizures. ( Persinger, MA; Venugopal, M, 1988) |
| "Seizures produced in rats by systemically administered pilocarpine (PILO) provide a model for studying the generation and spread of convulsive activity in the forebrain." | 3.67 | Only certain antiepileptic drugs prevent seizures induced by pilocarpine. ( Cavalheiro, EA; Coimbra, C; da Penha Berzaghi, M; Ikonomidou-Turski, C; Turski, L; Turski, WA, 1987) |
| "Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain." | 3.67 | Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra. ( Bortolotto, ZA; Cavalheiro, EA; De Moraes Mello, LE; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA, 1986) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 3.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats." | 3.67 | Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1986) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 3.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "The effects of 2-chloroadenosine, aminophylline, bicuculline, beta-carboline-3-carboxylic acid methylester and Ro 15-1788 on seizures produced by pilocarpine were examined in rats." | 3.67 | Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Mello, LE; Turski, L; Turski, WA, 1985) |
| "Microinjections of the cholinergic agonists, carbachol and bethanechol, either into the amygdala or into the dorsal hippocampus produced sustained limbic seizures and brain damage in rats." | 3.66 | Cholinomimetics produce seizures and brain damage in rats. ( Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA, 1983) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 3.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "2-deoxy-D-glucose has acute antiseizure actions in multiple in vivo and in vitro seizure models, including models of SE induced by the chemo convulsants pilocarpine and kainic acid, suggesting that focal enhanced delivery of 2DG to ictal brain circuits is a potential novel anticonvulsant intervention for the treatment of SE." | 3.01 | 2DG and glycolysis as therapeutic targets for status epilepticus. ( Fountain, NB; Sutula, TP, 2023) |
| "Interictal activity and seizures are the hallmarks of focal epileptic disorders (which include mesial temporal lobe epilepsy, MTLE) in humans and in animal models." | 3.01 | Evolution of interictal activity in models of mesial temporal lobe epilepsy. ( Avoli, M; Lévesque, M; Macey-Dare, ADB; Salami, P; Wang, S, 2023) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 2.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Although longer periods of seizures consistently result in brain damage, it has previously not been clear whether brief single or intermittent seizures lead to cell death." | 2.41 | Neuronal apoptosis after brief and prolonged seizures. ( Bengzon, J; Ekdahl, CT; Lindvall, O; Mohapel, P, 2002) |
| "Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization." | 2.41 | Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002) |
| "Drug-induced convulsions-often caused by the inhibition of GABA receptors and stimulation of glutamate receptors-are difficult to predict in animals." | 1.91 | Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats. ( Fujiki, M; Kuga, K; Ozaki, H, 2023) |
| "Long-term ANT-DBS significantly reduced seizure generalization in pilocarpine-induced epileptic rats." | 1.91 | Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study. ( Deng, J; Gao, JH; Guan, Y; Jing, B; Li, T; Liang, X; Luan, G; Tang, C; Wang, X; Xie, P; Xu, K; Zhou, J, 2023) |
| "Taurine (Tau) is an osmosensitive amino acid, whose release reflects increased cell volume." | 1.91 | Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus. ( Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Pawlik, M; Podgajna, M; Skowrońska, K; Węgrzynowicz, M, 2023) |
| "Epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures." | 1.91 | Upregulation of SLITRK5 in patients with epilepsy and in a rat model. ( Ai, M; Chen, H; Chen, L; Liu, Y; Mei, R; Pang, R; Xia, D; Zhang, L; Zhong, L, 2023) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is the most common chronic disorder in the nervous system, mainly characterized by recurrent, periodic, unpredictable seizures." | 1.91 | Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier. ( Huang, H; Luo, Y; Tai, Z; Xu, Z; Yang, J; Zhang, H; Zhang, L, 2023) |
| "After 3 hr of stage 5 acute seizure, hippocampal astrocytes show increased intrinsic calcium activity in stratum radiatum as well as reactive astrogliosis in the stratum lacunosum moleculare and hilus regions of the hippocampus." | 1.91 | Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus. ( Harshad, PA; Joshi, NB; Joshi, PG; Singh, M; Tewari, BP, 2023) |
| "Then, the spontaneous recurrent seizure (SRS) latency, SRS frequency and seizure duration were observed in each group." | 1.91 | The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress. ( Cao, H; Jia, L; Niu, X; Qiao, Q; Qu, Z; Tian, S; Wang, W; Zhang, B, 2023) |
| "During the 90 min of SE, epileptic seizures were analyzed according to the Racine's Scale." | 1.91 | N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model. ( Anselmo-E-Silva, CI; Caixeta, DC; Costa, MA; de Castro, OW; de Melo, IS; de Paula Soares Mendonça, T; de Souza, FMA; Dos Santos, YMO; Freitas-Santos, J; Goulart, LR; Oliveira, KB; Pacheco, ALD; Sabino-Silva, R; Vaz, ER, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 1.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy." | 1.91 | Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats. ( Diespirov, GP; Griflyuk, AV; Kalita, AD; Postnikova, TY; Sinyak, DS; Zaitsev, AV; Zubareva, OE, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 1.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "ANT-DBS alleviated seizure activity, abnormal locomotor behaviors, reduced theta-band, increased gamma-band EEG power in the interictal state, and increased the number of neurons in the dentate gyrus (DG)." | 1.72 | Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain. ( Bae, S; Jeong, Y; Kim, SG; Lim, HK; Park, SM; Shon, YM; Suh, M, 2022) |
| "Brivaracetam (BRV) is an anti-seizure drug for the treatment of focal and generalized epileptic seizures shown to augment short-term synaptic fatigue by slowing down synaptic vesicle recycling rates in control animals." | 1.72 | Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures. ( Han, X; Sun, Z; Xing, H; Xu, S; Yang, S, 2022) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 1.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| "Epilepsy is characterised by abnormal neuronal discharges, including aberrant expression of extracellular matrix (ECM) components and synaptic plasticity stabilisation." | 1.72 | Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats. ( Chen, L; Huang, H; Huang, Q; Niu, J; Ren, J; Su, X; Sun, T; Wan, D; Wang, P; Yang, L; Zhang, C, 2022) |
| "In the PV-ChR2 day 13 group, rates of seizures (p < 0." | 1.72 | Bilateral optogenetic activation of inhibitory cells favors ictogenesis. ( Avoli, M; Etter, G; Lévesque, M; Wang, S; Williams, S, 2022) |
| "However, the effect of seizures on Cx expression is controversial." | 1.72 | Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus. ( Andrioli, A; Barresi, V; Bentivoglio, M; Condorelli, DF; Di Liberto, V; Fabene, PF; Frinchi, M; Mudò, G, 2022) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 1.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "Gastrodin reduced the acute seizure severity in lithium-pilocarpine-induced seizure model." | 1.62 | Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. ( Chiu, SC; Huang, CW; Lai, MC; Liu, PY; Wu, SN; Yang, CS, 2021) |
| "Epilepsy was induced by pilocarpine, which was shown to produce long-lasting increases in NKCC1 in the hippocampus, whereas MEST did not alter NKCC1 mRNA in this region." | 1.62 | Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. ( Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaczmarek, E; Löscher, W; Römermann, K, 2021) |
| "The pilocarpine animal model has been broadly used to study the acute effects of seizures on neurogenesis and plasticity processes and the resulting epileptogenesis." | 1.62 | Effects of acute seizures on cell proliferation, synaptic plasticity and long-term behavior in adult zebrafish. ( Budaszewski Pinto, C; Cagliari Zenki, K; Calcagnotto, ME; Dalmaz, C; de Sá Couto-Pereira, N; Kawa Odorcyk, F; Losch de Oliveira, D, 2021) |
| "Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions." | 1.62 | Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021) |
| "Association of ROS production during seizure period was further confirmed by histopathological studies revealing loss of normal neuronal cells in hippocampus region." | 1.56 | Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice. ( Abbirami, E; Ruckmani, K; Sivasudha, T; Smilin Bell Aseervatham, G, 2020) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 1.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "The basic pathophysiology of epileptic seizures is still elusive, reflecting an extensive need for further research." | 1.56 | Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish. ( Abidin, SAZ; Kumari, Y; Othman, I; Paudel, YN; Shaikh, MF, 2020) |
| "Carvacrol (50 mg/kg) was injected once per day for 3 or 7 days after seizure." | 1.56 | The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kang, BS; Kang, DH; Kho, AR; Lee, SH; Lim, MS; Park, MK; Suh, SW, 2020) |
| "SE frequently induces chronic recurrent seizures after an extended latency referred to as epileptogenesis." | 1.51 | Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. ( Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H, 2019) |
| "IVA attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied." | 1.51 | Ivabradine possesses anticonvulsant and neuroprotective action in mice. ( Aguiar, CCT; Bessa, MC; Borges, LTN; Campos, AR; Cavalcante, TMB; Chaves Filho, AJM; De Melo, JMA; Fonteles, MMF; Lopes, LB; Macêdo, D; Santos, JG; Vasconcelos, LC; Vasconcelos, SMM; Vieira Neto, AE, 2019) |
| "Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region." | 1.51 | Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy. ( Barbieri, M; Bell, WJ; Emerich, DF; Falcicchia, C; Fradet, T; Kokaia, M; Lovisari, F; Paolone, G; Simonato, M; Wahlberg, LU, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 1.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Pilocarpine-induced SE was longer in mice with reduced adult neurogenesis, SE had more power and neuronal damage was greater." | 1.51 | Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures. ( Alcantara-Gonzalez, D; Botterill, JJ; Jain, S; LaFrancois, JJ; Scharfman, HE, 2019) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Furthermore, KN-93 is able to attenuate seizure behaviors by preventing its effects on neuron loss, so, it is valuable for the treatment of epileptic seizures." | 1.51 | Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat. ( Ebrahimi, F; Khamse, S; Mohammadian Haftcheshmeh, S; Mohseni-Moghaddam, P; Navid Hamidi, M; Roghani, M; Sadr, SS; Zamani, E, 2019) |
| "Epilepsy is a common chronic disease of the central nervous system that can last for years or even decades, causing serious adverse effects on the body, mind, and psychology of patients." | 1.51 | Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway. ( Qian, S; Tu, W, 2019) |
| "Behavioral (latency to first seizure and the percentage of clonic forelimb seizures), biochemical, and oxidative stress parameters were evaluated." | 1.48 | Gamma-Decanolactone Improves Biochemical Parameters Associated with Pilocarpine-Induced Seizures in Male Mice. ( Coelho, VR; da Silva, LL; Hoffmann, C; Nascimento, L; Pereira, P; Pfluger, P; Picada, JN; Regner, GG; Saffi, J; Viau, CM; Zanette, RA, 2018) |
| "Inflammation has detrimental influences on the developing brain including triggering the epileptogenesis." | 1.48 | Volumetric response of the adult brain to seizures depends on the developmental stage when systemic inflammation was induced. ( Janeczko, K; Kiepura, A; Kosonowska, E; Setkowicz, Z; Weglarz, W, 2018) |
| "Cortical dysplasia is the most common etiology of intractable epilepsy." | 1.48 | Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia. ( Feng, L; Wang, YL; Xiao, B; Yue, ZW, 2018) |
| "In the acute seizure model, both the behavioral and electrographic seizure activities were record and analyzed in rats for 90min, starting immediately after pilocarpine injection." | 1.46 | Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats. ( Chen, Y; Feng, Y; Han, X; Li, J; Liu, H; Mi, X; Wang, N; Wang, X; Zhang, Y; Zhao, T, 2017) |
| "In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i." | 1.46 | Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos. ( Braga, RM; da Fonsêca, DV; de Almeida, RN; de Farias, IEV; de Luna Freire Pessôa, H; de Melo, CGF; de Sousa, DP; do Amaral, IPG; Filho, MRDC; Lima, EM; Salgado, PRR, 2017) |
| "Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures." | 1.46 | Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity. ( Bekenstein, U; Berson, A; Friedman, A; Greenberg, DS; Hanin, G; Milikovsky, DZ; Mishra, N; Sheintuch, L; Soreq, H; Zelig, D, 2017) |
| "At the age of 2 months, seizures were induced, and pilocarpine and morphological changes of astrocytes located within the hippocampal formation were assessed." | 1.46 | Inflammation in the developing rat modulates astroglial reactivity to seizures in the mature brain. ( Janeczko, K; Kosonowska, E; Setkowicz, Z, 2017) |
| "In rats with frequent severe seizures, we found a clear loss of Prox1 and NeuN expression in the dentate granule cell layer (GCL), which was confined mainly to the suprapyramidal blade of the GCL at the septal and middle regions of the septotemporal axis of the hippocampus." | 1.46 | Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus. ( Seki, T; Toda, K; Uemori, T, 2017) |
| "The search for new treatments for seizures and epilepsy relies upon studies in animal models of epilepsy." | 1.46 | Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique. ( Anbazhagan, A; Chen, M; Reutens, DC; Tieng, QM, 2017) |
| "Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation." | 1.46 | Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2017) |
| "Seizures were induced by intraperitoneal injection of pilocarpine (25mg/kg) in male rats." | 1.46 | Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. ( Choi, BY; Choi, HC; Kho, AR; Kim, JH; Lee, SH; Sohn, M; Song, HK; Suh, SW, 2017) |
| " It is concluded that chronic administration β-estradiol has anticonvulsant and neuroprotective properties which are plausibly linked to astrocytic activity." | 1.46 | Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkar Boluki, T; Sarfi, M, 2017) |
| "The reduction on seizure burden was associated with a limited reduction on the generation of SBDPs but was correlated with a reduction in astrocytosis, microglia activation and cell sprouting." | 1.46 | A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. ( Carlsen, J; González, MI; Lam, PM, 2017) |
| "Once spontaneous seizures were established, we tested the locomotor activity (open field), spatial working memory (eight-arm radial maze), and sensorimotor gating (prepulse inhibition of acoustic startle)." | 1.43 | The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions. ( Bueno-Júnior, LS; Do Val Da Silva, RA; Kandratavicius, L; Leite, JP; Lopes-Aguiar, C; Wolf, DC, 2016) |
| "In this study, we observed the seizure behavior induced by kainic acid (20 mg/kg or 30 mg/kg) or pilocarpine (350 mg/kg) in AC8 KO and wild-type mice." | 1.43 | A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice. ( Chen, X; Dong, G; Wang, H; Yun, W; Zheng, C; Zhou, X, 2016) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 1.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Since traumatic brain injury is one of the strongest determinants of epileptogenesis, the present study focuses on the question whether a moderate long-term physical training can decrease susceptibility to seizures evoked following brain damage." | 1.43 | Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain. ( Gzieło-Jurek, K; Janeczko, K; Kaczyńska, M; Kosonowska, E; Setkowicz, Z, 2016) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 1.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Rosmarinic acid is a naturally occurring substance which displays several biological effects including antioxidant and neuroprotective activity." | 1.43 | Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. ( Freitas, ML; Furian, AF; Grauncke, AC; Grigoletto, J; Oliveira, CV; Oliveira, MS; Santos, AR; Souto, NS; Souza, TL, 2016) |
| "Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases." | 1.43 | Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. ( Chen, L; Chen, Y; Feng, Y; Li, B; Luo, Q; Shao, Y; Xie, Y, 2016) |
| "Neuroinflammation is known to be involved in epileptogenesis with unclear mechanisms." | 1.42 | Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. ( Hung, SW; Hung, YW; Lai, MT; Lee, TS; Lin, YY; Shih, YH; Wong, LK; Wu, YC, 2015) |
| "However, whether ENT1 plays a role in epileptic seizure that involves elevated glutamatergic neurotransmission is unknown." | 1.42 | ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission. ( Chen, G; Chen, Y; Fang, M; Liu, J; Luo, J; Lv, Y; Wang, J; Wang, K; Wang, X; Xu, P; Xu, Z; Zhang, J; Zhang, Y, 2015) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 1.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "Only 29% of LEV-treated animals had seizures compared to all controls following a latent period that was similar in duration." | 1.42 | The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M, 2015) |
| "However, its role in seizures and postictal outcomes is still not fully understood." | 1.42 | PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. ( Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB, 2015) |
| "Status epilepticus is an emergency condition in patients with prolonged seizure or recurrent seizures without full recovery between them." | 1.42 | State and parameter estimation of a neural mass model from electrophysiological signals during the status epilepticus. ( Castillo-Toledo, B; López-Cuevas, A; Medina-Ceja, L; Ventura-Mejía, C, 2015) |
| "Anti-seizure drugs are the most commonly employed treatment option for epilepsy and these generally provide effective management of seizures." | 1.42 | Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats. ( Pilitsis, JG; Shin, DS; Smith, AB; Yu, W, 2015) |
| "Treatment with pilocarpine (PILO) induces variable degrees of loss of mossy cells (MCs) and mossy fibre (MF) sprouting in rodents, the relationships of which have not been examined in individual animals." | 1.42 | Comparative immunohistochemical study of the effects of pilocarpine on the mossy cells, mossy fibres and inhibitory neurones in murine dentate gyrus. ( Dobó, E; Károly, N; Mihály, A, 2015) |
| "TRPC6 knockdown increased seizure susceptibility, excitability ratio and paired-pulse inhibition in the dentate gyrus (DG) of normal animals." | 1.42 | The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. ( Kang, TC; Kim, YJ, 2015) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Although not prone to spontaneous seizures, Kv2." | 1.40 | Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. ( Bishop, HI; Campi, KL; Doisy, ET; Eum, K; Golub, MS; Hell, JW; Mandikian, D; Matt, L; Nerbonne, JM; Ogata, G; Sack, JT; Schwartzkroin, PA; Speca, DJ; Trainor, BC; Trimmer, JS; Wenzel, HJ; Wiler, SW, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Lmx1b(f/f/p) mice had a lower seizure threshold and increased seizure-induced mortality." | 1.40 | Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. ( Buchanan, GF; Hajek, MA; Murray, NM; Richerson, GB, 2014) |
| "Seizures have been shown to upregulate the expression of numerous extracellular matrix molecules." | 1.40 | Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model. ( Arriaga-Avila, V; Guevara-Guzmán, R; Landgrave-Gómez, J; Mercado-Gómez, O; Nebreda-Corona, A, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| "Pilocarpine treated rats that exhibited spontaneous seizures were implanted with drivable tetrodes including an LFP electrode and recordings were obtained from the CA3 region." | 1.39 | Neuronal synchrony and the transition to spontaneous seizures. ( Grasse, DW; Karunakaran, S; Moxon, KA, 2013) |
| "Diabetes can exacerbate seizures and worsen seizure-related brain damage." | 1.39 | Pregabalin attenuates excitotoxicity in diabetes. ( Cheng, JT; Huang, CC; Huang, CW; Lai, MC; Tsai, JJ; Wu, SN, 2013) |
| "In the pilocarpine-induced seizure model, all dosages of agomelatine or melatonin showed a significant decrease in TBARS levels and nitrite content in all brain areas when compared to controls." | 1.39 | Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. ( Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM, 2013) |
| " Luteolin did not exhibit any consistent anti- or pro-convulsant actions after single dosing in the 6 Hz (0." | 1.39 | Anticonvulsant screening of luteolin in four mouse seizure models. ( Borges, K; Shaikh, MF; Tan, KN, 2013) |
| "Li-PIL-induced seizures were accompanied by increased levels of hippocampal prostaglandin (PG) E2, myeloperoxidase (MPO), tumor necrosis factor-α, and interleukin-10." | 1.39 | Additional antiepileptic mechanisms of levetiracetam in lithium-pilocarpine treated rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2013) |
| "The 6-Hz psychomotor seizure model in mice is increasingly been used as a model for differentiation of anticonvulsant activity during development of new antiepileptic drugs (AEDs)." | 1.39 | Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model. ( Bankstahl, JP; Bankstahl, M; Löscher, W, 2013) |
| "Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons." | 1.39 | Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. ( Abramowitz, J; Birnbaumer, L; Flockerzi, V; Freichel, M; Gottschall, PE; Howell, MD; Phelan, KD; Rhee, SW; Shwe, UT; Wu, H; Zheng, F, 2013) |
| "EEG documented seizure activity and status epilepticus (SE) developed in 87." | 1.39 | Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. ( Chang, FC; Jou, SB; Kao, IF; Yi, PL, 2013) |
| "Pilocarpine-induced seizure increased p47 immunofluorescence in the plasma membrane of hippocampal neurons at 12h post-insult and apocynin treatment prevented this increase." | 1.39 | Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death. ( Choi, BY; Choi, HC; Chung, TN; Jang, BG; Kim, HS; Kim, JH; Sohn, M; Song, HK; Suh, SW, 2013) |
| "The duration of sustained seizures (SS) plays a crucial role in the occurrence of spontaneous recurrent seizures (SRS) in experimental animals." | 1.38 | The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats. ( Huang, PY; Hung, YW; Kuo, TB; Lee, TS; Lin, YY; Shih, YH; Yang, DI; Yiu, CH, 2012) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 1.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior." | 1.38 | Social behavior impairment in offspring exposed to maternal seizures in utero. ( Amado, D; Cysneiros, RM; Novaes, GF; Scorza, FA, 2012) |
| "Pretreatment with baicalin significantly delayed the onset of the first limbic seizures and SE, reduced the mortality rate, and attenuated the changes in the levels of lipid peroxidation, nitrite content and reduced glutathione in the hippocampus of pilocarpine-treated rats." | 1.38 | The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. ( Gao, F; Jia, RH; Jiang, W; Jing, YY; Li, XW; Liu, YF; Meng, XD; Wang, Y; Zhao, R, 2012) |
| "First, we repeatedly determined the PTZ seizure threshold by i." | 1.38 | Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. ( Brandt, C; Löscher, W; Rattka, M, 2012) |
| "The mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2." | 1.38 | A strength exercise program in rats with epilepsy is protective against seizures. ( Arida, RM; Cassilhas, R; Cavalheiro, EA; de Almeida, AA; de Mello, MT; Fernandes, J; Novaes Gomes, FG; Peixinho-Pena, LF; Scorza, FA; Venancio, DP, 2012) |
| "Several studies have shown that epileptic seizures increase hippocampal neurogenesis in the adult." | 1.38 | Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure. ( Choi, BY; Jang, BG; Kim, JH; Kwon, LM; Sohn, M; Song, HK; Suh, SW, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 1.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Pilocarpine treatment significantly reduced the GAP-43 immunoreactivity in the inner molecular layer in both species, with some minor differences in the staining pattern." | 1.37 | Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy. ( Dobó, E; Károly, N; Mihály, A, 2011) |
| "Decreased seizure frequency (≥ 50%) or interruption of status epilepticus was observed in the majority of the subjects, regardless of the underlying pathology." | 1.37 | Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. ( Alexopolous, A; Ciusani, E; Freri, E; Granata, T; Janigro, D; Marchi, N; Puvenna, V; Ragona, F; Teng, Q, 2011) |
| "To reveal putative seizure-induced changes in blood-brain barrier integrity, we performed gadolinium-enhanced magnetic resonance scans on a 7." | 1.37 | A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier. ( Bankstahl, JP; Bankstahl, M; Ding, XQ; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Wanek, T, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Pilocarpine was administered on postnatal day 25 and mortality rates were measured after 2 and 24h." | 1.37 | Prenatal exposure to restraint or predator stresses attenuates field excitatory postsynaptic potentials in infant rats. ( Ahmadzadeh, R; Roshan-Milani, S; Saboory, E, 2011) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 1.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "In pilocarpine group, it was observed a significant decreased in ChAT and AChE activities, when compared to control group." | 1.36 | Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. ( de Freitas, RM; de Sales Santos, IM; Feitosa, CM, 2010) |
| "In pilocarpine group there was a significant increase in hydroperoxides concentration and glutathione peroxidase activity." | 1.36 | Effects of ubiquinone on hydroperoxide concentration and antioxidant enzymatic activities in the rat hippocampus during pilocarpine-induced seizures. ( da Silva, EP; de Freitas, RL; de Freitas, RM; Feitosa, CM; Feng, D; Saldanha, GB; Santos, IM; Souza, GF; Tomé, Ada R, 2010) |
| "Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale." | 1.36 | Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. ( Costa-Ferro, ZS; Cunha, FB; DaCosta, JC; Machado, DC; Pedroso, MF; Ribeiro-dos-Santos, R; Soares, MB; Vitola, AS; Xavier, LL, 2010) |
| "During seizures, firing of individual neurons and interneuronal synchronization further increased." | 1.36 | Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo. ( Cymerblit-Sabba, A; Schiller, Y, 2010) |
| "These findings suggest that spontaneous seizures and associated ERK activation could contribute to the proliferation of radial glia-like NPCs in this epilepsy model." | 1.36 | Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy. ( Houser, CR; Li, Y; Peng, Z; Xiao, B, 2010) |
| "It has long been held that chronic seizures cause blood-brain barrier (BBB) damage." | 1.36 | Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity. ( Bawa, H; Desai, NK; Fan, Q; Ghosh, C; Janigro, D; Marchi, N; Masaryk, TK; Nguyen, MT; Rasmussen, P; Teng, Q, 2010) |
| "We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring." | 1.36 | Seizures during pregnancy modify the development of hippocampal interneurons of the offspring. ( Amado, D; Cabral, FR; Cavalheiro, EA; Cossa, AC; da Silva, AV; de Lima, E; de Oliveira, EM; do Vale, TG; Lima, DC; Naffah-Mazzacoratti, Mda G; Torres, LB, 2010) |
| "PTZ injection induced clonic seizures in MCH(1)R-WT mice but failed to induce them in MCH(1)R-KO mice." | 1.36 | Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. ( Civelli, O; Gohil, K; Okumura, SM; Parks, GS, 2010) |
| "In the remaining animals that exhibited seizures, KB-R7943 pretreatment delayed the onset of seizures and status epilepticus, and reduced seizure severity." | 1.36 | Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. ( Martinez, Y; N'Gouemo, P, 2010) |
| "We report that brief seizures evoked by electroshock produced an increase in the number of NPY neurons in the dentate hilus and retrosplenial cortex, an effect that lasted 10 weeks." | 1.36 | Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis. ( Cardoso, A; Carvalho, LS; Freitas-da-Costa, P; Lukoyanov, NV, 2010) |
| "Whereas propagated seizures are known to disrupt cerebral activity, little work has been done on remote network effects of seizures that do not propagate." | 1.35 | Remote effects of focal hippocampal seizures on the rat neocortex. ( Blumenfeld, H; Englot, DJ; Herman, P; Hyder, F; Mansuripur, PK; Mishra, AM, 2008) |
| "One day after seizures were induced, swim stressed rats showed significantly fewer degenerating neurons in the hippocampus as revealed by Fluoro-Jade B staining." | 1.35 | Profound hypothermia determines the anticonvulsant and neuroprotective effects of swim stress. ( Fournier, NM; Galic, MA; Kalynchuk, LE; Persinger, MA, 2008) |
| "Ketamine-treated seized rats were healthier than acepromazine-treated seized rats or normal rats." | 1.35 | Large differences in blood measures, tissue weights, and focal areas of damage 1 year after postseizure treatment with acepromazine or ketamine. ( Blomme, CG; Dupont, MJ; George, KR; Mazzuchin, A; Persinger, MA; Rico, T; St-Pierre, LS; Stewart, LS, 2009) |
| "Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood." | 1.35 | Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009) |
| "Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon." | 1.35 | Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. ( Cheng, JT; Huang, CC; Huang, CW; Tsai, JJ; Wu, SN, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS)." | 1.35 | Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice. ( Kalra, R; Rehni, AK; Singh, N; Singh, TG, 2009) |
| " In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies." | 1.35 | Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. ( Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009) |
| "The behavioral signs of the developing epileptic seizures were scored in all rats." | 1.35 | Status epilepticus affects the gigantocellular network of the pontine reticular formation. ( Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V, 2009) |
| "Seizures were evoked in freely moving rats by intrahippocampal microperfusion, via a microdialysis probe, of the muscarinic receptor agonist pilocarpine (10mM), GABA(A) receptor antagonist picrotoxin (100microM) or group I metabotropic glutamate receptor agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) (1mM)." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "Transition into limbic seizures and recurrent seizures were delayed in both age groups and threshold intensities for limbic ADs were at some intervals higher in SE than in control animals." | 1.35 | Changes of cortical epileptic afterdischarges after status epilepticus in immature rats. ( Kubová, H; Mares, P; Tsenov, G, 2008) |
| "ACh-induced seizure-like events could be completely blocked by the non-specific muscarinic antagonist, atropine, and were partially blocked by the muscarinic-1 receptor antagonist, pirenzepine; but were not affected by the non-specific nicotinic antagonist, mecamylamine." | 1.35 | Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. ( Behrens, CJ; Friedman, A; Gross, M; Heinemann, U; Ivens, S; Njunting, M; Soreq, H; Tolner, E; Tolner, EA; Zimmerman, G, 2008) |
| "The data indicate that seizure-induced glutamate release is involved in the regulation of Pgp expression, which can be blocked by MK-801." | 1.35 | Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. ( Bankstahl, JP; Bethmann, K; Hoffmann, K; Löscher, W, 2008) |
| "Bromodeoxyuridine (BrdU) was intraperitoneally administered 36h before the rats were sacrificed." | 1.34 | Consequences of pilocarpine-induced recurrent seizures in neonatal rats. ( Ji-Wen, W; Ruo-Peng, S; Xiu-Yu, S, 2007) |
| "We studied IS in two seizure models; pilocarpine-induced status epilepticus and recurrent flurothyl models." | 1.34 | Effect of interictal spikes on single-cell firing patterns in the hippocampus. ( Holmes, GL; Lenck-Santini, PP; Zhao, Q; Zhou, JL, 2007) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 1.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "Epileptic seizures cause severe and long-lasting events on the architecture of the brain, including neuronal cell death, accompanied neurogenesis, reactive gliosis, and mossy fiber sprouting." | 1.33 | Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. ( Hagihara, H; Hara, M; Nakagawa, Y; Nakano, K; Sawada, M; Tsunekawa, K, 2005) |
| "However, the seizure threshold of AE3-knockout mice exposed to bicuculline, pentylenetetrazole, or pilocarpine was reduced, and seizure-induced mortality was significantly increased compared to wild-type littermates." | 1.33 | Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold. ( Gal, A; Hentschke, M; Hentschke, S; Hermans-Borgmeyer, I; Hübner, CA; Jentsch, TJ; Kurth, I; Seidenbecher, T; Wiemann, M, 2006) |
| "Ketamine-treated pilocarpine-seized rats and normal rats were exposed continuously either to a complex sequence magnetic field or to control conditions during the acquisition of a radial arm maze task for 8 consecutive days." | 1.33 | Weak, physiologically patterned magnetic fields do not affect maze performance in normal rats, but disrupt seized rats normalized with ketamine: possible support for a neuromatrix concept? ( McKay, BE; Persinger, MA, 2006) |
| "In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizure-induced synaptic reorganization." | 1.33 | Seizures accelerate functional integration of adult-generated granule cells. ( Bensen, AL; Bromberg, DA; Overstreet-Wadiche, LS; Westbrook, GL, 2006) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 1.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "The rats of seizure group were subjected to three times of pilocarpine injections intraperitonealy at postnatal day 1 (P1), 4 (P4) and 7 (P7)." | 1.33 | [Effects and consequence of recurrent seizures of neonatal rat on the hippocampal neurogenesis]. ( Shi, XY; Sun, RP; Wang, JW, 2006) |
| "Thereafter, seizures were induced by pilocarpine injections in trained and non-trained control groups." | 1.33 | Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat. ( Mazur, A; Setkowicz, Z, 2006) |
| "Prolonged seizures in early childhood are associated with an increased risk of development of epilepsy in later life." | 1.32 | Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. ( Brooks-Kayal, AR; Hsu, FC; Raol, YS; Zhang, G, 2004) |
| "Spontaneous recurrent seizures were measured using videotaping, and seizure susceptibility was tested with flurothyl inhalation." | 1.32 | Detrimental effects of the ketogenic diet on cognitive function in rats. ( Fu, DD; Holmes, GL; Hu, Y; Stafstrom, CE; Zhao, Q, 2004) |
| "Here, effects of pilocarpine-induced seizure activity on total BDNF expression and on the individual sensitivity of BDNF transcripts to glutamate receptor and Ca2+ channel blockers were evaluated using hippocampal slice cultures and in situ hybridization of transcript-specific cRNA probes directed against mRNAs for the four 5' exons (I-IV) of the BDNF gene." | 1.32 | Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. ( Gall, CM; Lauterborn, J; Poulsen, FR; Zimmer, J, 2004) |
| "To test whether seizure-prone phenotypes exhibit increased seizure-related morphological changes, we compared two standard rat strains (Long-Evans hooded and Wistar) and two specially bred strains following status epilepticus." | 1.32 | Strain differences affect the induction of status epilepticus and seizure-induced morphological changes. ( Fahnestock, M; McIntyre, DC; Racine, RJ; Xu, B, 2004) |
| "It is known that evoked seizures can increase neurogenesis in the dentate gyrus in adult rats." | 1.32 | Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis. ( Akman, C; Cha, BH; Holmes, GL; Liu, X; Silveira, DC, 2004) |
| "Many animals developed seizures of varying severity and length." | 1.32 | Neuropathology of seizures in the immature rabbit. ( Brucklacher, R; Housman, C; Towfighi, J; Vannucci, RC, 2004) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 1.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "The numbers of spontaneous seizures per day during a 15 min observation interval were recorded for each rat during the treatment period and during an additional 30 days when only tap water was given." | 1.32 | Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures. ( Peredery, O; Persinger, MA, 2004) |
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 1.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| "The pilocarpine effect was blocked by simultaneous superfusion with the muscarinic receptor antagonist atropine (100 microM)." | 1.31 | Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures. ( Blaabjerg, M; Jahnsen, H; Poulsen, FR; Zimmer, J, 2002) |
| "The data indicate that recurrent seizures which persistently occur in this model were not responsible for the increased DeltaFosB expression." | 1.31 | Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy. ( DeLorenzo, RJ; Jafari, N; Morris, TA, 2000) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 1.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "Spontaneous behavioral seizures were observed in BDNF-infused rats (8/32; 25%) but not in controls (0/20; 0%)." | 1.31 | Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. ( Croll, SD; Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| "We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine." | 1.31 | Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. ( Shibley, H; Smith, BN, 2002) |
| "TBM also inhibited seizures induced by pentylenetetrazol (PTZ), electrical kindling, and the combination of lithium sulfate and pilocarpine nitrate (Li-Pilo)." | 1.31 | Anticonvulsive activity of Butea monosperma flowers in laboratory animals. ( Chopde, CT; Kasture, SB; Kasture, VS, 2002) |
| "2." | 1.30 | MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats. ( Choi, BJ; Chou, JY; Kim, CY; Kim, SK; Lee, KH; Lee, MG, 1997) |
| "Seizures have been shown to regulate neurotrophin expression in adult mammalian brain." | 1.30 | Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain. ( Gall, CM; Kornblum, HI; Sankar, R; Shin, DH; Wasterlain, CG, 1997) |
| "The principal elements of the seizures are wet-rat-shakes, facial and forelimb clonus, rearing and spike-and-waves in the EEG." | 1.30 | The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine. ( Dürmüller, N; Graham, JL; Meldrum, BS; Sowinski, P, 1997) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 1.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "Vasotocin and oxytocin were without effect." | 1.30 | Proconvulsive effect of vasopressin; mediation by a putative V2 receptor subtype in the central nervous system. ( Croiset, G; De Wied, D, 1997) |
| "Temporal lobe epilepsy is the most prevalent seizure disorder in adults." | 1.30 | Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. ( Brooks-Kayal, AR; Coulter, DA; Jin, H; Rikhter, TY; Shumate, MD, 1998) |
| "Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats." | 1.30 | Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. ( Fike, JR; Lowenstein, DH; Parent, JM; Tada, E, 1999) |
| "Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression." | 1.30 | Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999) |
| "Pilocarpine-treated rats were studied because they not only have seizures and increased BDNF expression in granule cells, but they also have reorganization of granule cell "mossy fiber" axons." | 1.30 | Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 1999) |
| "Cell death, reactive gliosis, and axonal sprouting are among the best studied alterations in the epileptic brain." | 1.30 | Differential regulation of cytokine expression following pilocarpine-induced seizure. ( Jankowsky, JL; Patterson, PH, 1999) |
| " The brains of rats that had received this small dosage of lithium and pilocarpine exhibited discernable infiltrations of lymphocytes within limbic tracts but no discernable neuronal loss." | 1.30 | Infiltration of lymphocytes in the limbic brain following stimulation of subclinical cellular immunity and low dosages of lithium and a cholinergic agent. ( Cook, LL; Persinger, MA, 1999) |
| "The numbers of Level 5 (Racine) seizures, inferred by the rat's rearing, rapid forelimb clonus, and falling, were statistically more frequent for the frequency-modulated (Thomas) pattern when its pixel duration and interstimulus presentation were 3 msec." | 1.30 | Facilitation of seizures in limbic epileptic rats by complex 1 microTesla magnetic fields. ( Belanger-Chellew, G; Persinger, MA, 1999) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 1.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| "These seizures were followed by seemingly complete neurological recovery." | 1.29 | Long-term behavioral deficits following pilocarpine seizures in immature rats. ( Gatt, A; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ, 1994) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 1.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| "We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine." | 1.29 | Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "We have used the pilocarpine-induced seizure model in mice and i." | 1.29 | Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. ( Deirmengiant, C; Maslanski, JA; Patelt, J; Powelt, R, 1994) |
| "Inositol-4-phosphate was stable in the young rats but increased in the frontal cortex and the hippocampus in the old rats." | 1.29 | Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats. ( Hirvonen, MR; Paljärvi, L; Savolainen, KM, 1993) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 1.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "Male adult rats that displayed limbic seizures between postnatal days 18 and 21 after a single s." | 1.29 | Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: implications for early brain injuries. ( Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| "(ranging from 2-13 seizures/day) in 40-165 days, and this period of high frequency of seizures lasted for 20-95 days." | 1.29 | Decreased time constant in hippocampal dentate granule cells in pilocarpine-treated rats with progressive seizure frequencies. ( Isokawa, M, 1996) |
| "after seizure induction than for those who received the same field over the left hemisphere or that had been exposed to reference conditions." | 1.29 | Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury. ( Cook, LL; Persinger, MA, 1996) |
| "Here we evaluated whether spontaneous seizures would lead to similar impairments." | 1.29 | Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. ( Covolan, L; Mello, LE, 1996) |
| "Pretreatment with reserpine had no effect on either the time to onset or duration of maximal dentate activation." | 1.28 | Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus. ( Lothman, EW; Stringer, JL, 1991) |
| "Rats were observed for seizure activity for 2 h, survivors were killed 24 h later and edema was measured in samples from parietal and piriform cortices, dorsal thalmus, and hippocampus." | 1.28 | Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats. ( Nelson, SR; Padzernik, TL; Terry, JB, 1990) |
| "Subsequently electrographic seizures appeared in both limbic and cortical leads." | 1.27 | Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. ( Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Schwarz, M; Turski, L; Turski, WA, 1983) |
| "We have used limbic convulsions induced by systemic pilocarpine in rats combined with focal intracerebral injections concurrently to study the initiation and spread of seizure activity." | 1.27 | Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "Organized electrographic seizure activity developed just prior to the onset of behavioral forelimb clonus and appeared to originate from ventral forebrain in the vicinity of the ventral pallidum and/or nucleus accumbens." | 1.27 | The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. ( Clifford, DB; Collins, RC; Maniotis, A; Olney, JW; Zorumski, CF, 1987) |
| "No overt motor seizures were observed in this age group." | 1.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 1.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "Hexobarbital was infused continously." | 1.26 | The interaction between pilocarpine and hexobarbital in male rats. ( Wahlström, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (5.96) | 18.7374 |
| 1990's | 114 (14.77) | 18.2507 |
| 2000's | 188 (24.35) | 29.6817 |
| 2010's | 327 (42.36) | 24.3611 |
| 2020's | 97 (12.56) | 2.80 |
| Authors | Studies |
|---|---|
| Yi, YJ | 1 |
| Ran, X | 1 |
| Xiang, J | 1 |
| Li, XY | 1 |
| Jiang, L | 3 |
| Chen, HS | 1 |
| Hu, Y | 5 |
| Wang, Y | 10 |
| Yuan, J | 1 |
| Yu, X | 3 |
| Liu, X | 10 |
| Tan, C | 1 |
| Chen, Y | 12 |
| Xu, T | 2 |
| Pawlik, MJ | 2 |
| Aldana, BI | 1 |
| Belfiori-Carrasco, LF | 1 |
| Obara-Michlewska, M | 2 |
| Popek, MP | 2 |
| Czarnecka, AM | 3 |
| Albrecht, J | 3 |
| Lee, WJ | 1 |
| Moon, J | 1 |
| Lim, JA | 1 |
| Jeon, D | 2 |
| Yoo, JS | 1 |
| Park, DK | 1 |
| Han, D | 1 |
| Lee, ST | 3 |
| Jung, KH | 3 |
| Park, KI | 1 |
| Lee, SK | 3 |
| Chu, K | 3 |
| Gorlewicz, A | 1 |
| Barthet, G | 1 |
| Zucca, S | 1 |
| Vincent, P | 1 |
| Griguoli, M | 1 |
| Grosjean, N | 1 |
| Wilczynski, G | 1 |
| Mulle, C | 1 |
| Vigier, A | 1 |
| Partouche, N | 1 |
| Michel, FJ | 1 |
| Crépel, V | 1 |
| Marissal, T | 1 |
| Singh, S | 2 |
| Singh, TG | 4 |
| Singh, M | 2 |
| Najda, A | 1 |
| Nurzyńska-Wierdak, R | 1 |
| Almeer, R | 1 |
| Kamel, M | 1 |
| Abdel-Daim, MM | 1 |
| Javed, L | 1 |
| Hanif, F | 1 |
| Malhi, SM | 2 |
| Zaman, U | 1 |
| Jahan, N | 1 |
| Amir, Q | 1 |
| Javed, A | 1 |
| Malik, AB | 1 |
| Abrar, H | 1 |
| Dyomina, AV | 1 |
| Kovalenko, AA | 2 |
| Zakharova, MV | 1 |
| Postnikova, TY | 2 |
| Griflyuk, AV | 2 |
| Smolensky, IV | 1 |
| Antonova, IV | 1 |
| Zaitsev, AV | 3 |
| Dal Pai, J | 1 |
| da Silva, JC | 1 |
| Sanabria, V | 1 |
| Amorim, RP | 1 |
| Predebon, G | 1 |
| Cossa, AC | 3 |
| Trindade-Filho, E | 1 |
| Amado, D | 8 |
| Nagib, MM | 1 |
| Zhang, S | 3 |
| Yasmen, N | 1 |
| Li, L | 2 |
| Hou, R | 1 |
| Yu, Y | 1 |
| Boda, VK | 1 |
| Wu, Z | 1 |
| Li, W | 1 |
| Jiang, J | 1 |
| Aourz, N | 6 |
| Van Leuven, F | 1 |
| Allaoui, W | 1 |
| Van Eeckhaut, A | 2 |
| De Bundel, D | 6 |
| Smolders, I | 25 |
| Bae, S | 1 |
| Lim, HK | 1 |
| Jeong, Y | 1 |
| Kim, SG | 1 |
| Park, SM | 1 |
| Shon, YM | 1 |
| Suh, M | 1 |
| Xing, H | 2 |
| Han, X | 3 |
| Xu, S | 1 |
| Sun, Z | 2 |
| Yang, S | 1 |
| Mallmann, MP | 1 |
| Mello, FK | 1 |
| Neuberger, B | 1 |
| da Costa Sobral, KG | 1 |
| Fighera, MR | 2 |
| Royes, LFF | 2 |
| Furian, AF | 4 |
| Oliveira, MS | 6 |
| Seo, GY | 1 |
| Neal, ES | 1 |
| Han, F | 1 |
| Vidovic, D | 1 |
| Nooru-Mohamed, F | 1 |
| Dienel, GA | 1 |
| Sullivan, MA | 1 |
| Borges, K | 4 |
| Trindade-Filho, EM | 2 |
| Pai, JD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Searching for Exosomal microRNAs and Cellular Biomarkers and Mechanisms Underlying the Differences Between Panic Disorder Patients Who Are Responders and Non-responders to Cognitive Behavior Therapy[NCT04029740] | 80 participants (Anticipated) | Interventional | 2019-03-24 | Recruiting | |||
| Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy[NCT00916266] | Phase 1 | 20 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Clinical and Genetic Factors Associated With Drug Resistance of Epilepsy[NCT04166305] | 180 participants (Anticipated) | Observational | 2019-11-01 | Recruiting | |||
| A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy[NCT01281956] | Phase 2 | 12 participants (Actual) | Interventional | 2011-01-07 | Terminated | ||
| Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease[NCT04650932] | 10 participants (Anticipated) | Interventional | 2022-10-22 | Recruiting | |||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Does Memantine Improve Verbal Memory Task Performance in Subjects With Localization-related Epilepsy and Memory Dysfunction? A Randomized, Double-Blind, Placebo-Controlled Trial[NCT01054599] | 29 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants were administered the Hamilton Anxiety Rating Scale (HAM-A) at the end of each three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. The HAM-A measures an individual's severity of anxiety symptoms. The scale consists of 14 parameters, each defined by a series of symptoms. Each group of symptoms is scored on a scale of 0 (not present) to 4 (severe), with a total score range of 0-56, where 30 severe anxiety. (NCT01281956)
Timeframe: Three months
| Intervention | score on a scale (Mean) |
|---|---|
| PRX-0023 | 5.1 |
| Placebo | 5.7 |
The Hamilton Depression Rating Scale (HAM-D) was administered to participants at the end of each treatment period. The HAM-D is a multiple item questionnaire used to provide an indication of depression. The questionnaire is designed for adults and is used to rate the severity of their depression by probing mood, feelings of guilt, suicide ideation, insomnia, agitation or retardation, anxiety, weight loss, and somatic symptoms. Although the HAM-D form lists 21 items, the scoring is based on the first 17 items. Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine items are scored from 0-2 with 0 = absent and 2 = frequent or severe. Scores range from 0 to 50 with a score of 0-7 representing normal and a score >/= 23 representing very severe depression. (NCT01281956)
Timeframe: Three months
| Intervention | score on a scale (Mean) |
|---|---|
| PRX-0023 | 5.3 |
| Placebo | 8.6 |
Participants used a seizure calendar to record the number of seizures that occurred during each three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. Seizure rate was calculated as the total number of seizures occurring during the three month period. The number of participants with >50% lower seizure frequency during the active compared with the placebo period was determined. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) |
|---|---|
| All Participants Who Completed Study | 0 |
An electrocardiogram was administered to participants at the end of each treatment period, i.e., at the end of the PRX-0023 and Placebo treatment periods. The number of abnormal ECG readings was noted in this measure. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) |
|---|---|
| PRX-0023 | 2 |
| Placebo | 3 |
Participants used a seizure calendar to record the number of seizures that occurred during the three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. Seizure frequency was calculated as the total number of seizures occurring during each three month period. For each period a mean was calculated across subjects. (NCT01281956)
Timeframe: Three months
| Intervention | number of seizures (Mean) |
|---|---|
| PRX-0023 | 66.6 |
| Placebo | 54.3 |
The HVLT-R is a word-list learning and memory test.The participant is read a list of words and asked to recall as many as possible, without regard to the order in which they were read.The list is read three times with recall requested after each presentation (immediate recall) and after a delay (delayed recall). Individual test results are compared to others of the same age (+/-5 years).Test results are presented as T-scores which are conventionally used in neuropsychology. The participant's raw scores are compared to a population expected raw score, for a particular age group. That score is converted to a T-score.The interpretation of these T-scores is such that 50 is representative of the normal score in that age group in the general population. The standard deviation of these distributions are 10 units. Therefore, a score between 30-40 is considered mildly impaired, 20-30 is indicative of severe problems with learning and memory and a score of 60-70 indicates a very good memory. (NCT01281956)
Timeframe: Three months
| Intervention | psychometric T-score (Mean) | |
|---|---|---|
| Immediate Recall | Delayed Recall | |
| Placebo | 41.6 | 39.2 |
| PRX-0023 | 34.8 | 33.3 |
The number of subjects with abnormal clinical chemistry labs which is defined as a value outside of the NIH Clinical Center normal range. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| electrolyte abnormality | hyperglycemia | elevated liver function < 2 x normal | elevated liver function > 2 x normal | abnormal urinalysis | elevated uric acid | elevated BUN or Creatinine | |
| Placebo | 4 | 1 | 3 | 0 | 4 | 1 | 0 |
| PRX-0023 | 4 | 2 | 3 | 1 | 3 | 0 | 0 |
A Complete Blood Count (CBC) was administered at the end of each three month treatment period. A complete blood count test measures several components and features of your blood, including: Red blood cells (which carry oxygen), White blood cells (which fight infection), Hemoglobin (the oxygen-carrying protein in red blood cells), Hematocrit (the proportion of red blood cells to the fluid component (plasma) in your blood), Platelets, (which help with blood clotting). Abnormal increases or decreases in cell counts as revealed in a complete blood count may indicate an underlying medical condition, i.e., anemia (abnormal red blood cells, hemoglobin, and/or hematocrit), leucopenia (a decrease in white blood cells), leucocytosis (an increase in white blood cells), and thrombocytosis (an increase in platelets). Results were classified as either normal or abnormal. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| anemia | leucopenia | leucocytosis | thrombocytosis | |
| Placebo | 1 | 1 | 3 | 2 |
| PRX-0023 | 2 | 2 | 2 | 0 |
The BVMT-R is a test of memory for visual information. Participants are shown a page with several geometric designs arranged in a 2x3 matrix and asked to study the designs. After the page is shown for a brief period the participant is asked to draw each figure.The same page is shown three times with recall requested after each presentation (immediate recall) and after a delay (delayed recall). Individual test results are compared to other people the same age (+/- 5 years).Test results are presented as T-scores which are conventionally used in neuropsychology. The participant's raw scores are compared to a population expected raw score, for a particular age group.That score is converted to a T-score.The interpretation of these T-scores is such that 50 is representative of the normal score in that age group in the general population.The standard deviation of these distributions are 10 units. A score of 30-40 is considered mildly impaired, 20-30 is indicative of severe problems (NCT01281956)
Timeframe: Three months
| Intervention | psychometric T-score (Mean) | |
|---|---|---|
| Immediate Recall | Delayed Recall | |
| Placebo | 39.0 | 37.4 |
| PRX-0023 | 37.4 | 38.0 |
SRT-CLTR (range 0-72; higher scores indicate better memory), and 7-24 Spatial Memory Test (range 0-35; scores are summed across the 5 learning trials, with higher scores indicating better memory) scores will be assessed across the first (baseline) and third (post-open label memantine) testing sessions. These measures are considered to be scores on a scale, rather than standard units. The hypothesis was that subjects randomized to memantine would demonstrate sustained improvement from baseline, while the placebo group would demonstrate improvements after taking open label memantine (compared to baseline). (NCT01054599)
Timeframe: 26 weeks
| Intervention | scores on a scale (Mean) | |||
|---|---|---|---|---|
| SRT CLTR Baseline | SRT CLTR Post-Open Label | 7-24 Total Learning Baseline | 7-24 Total Learning Post-Open Label | |
| Memantine | 32.67 | 40.33 | 30.33 | 31.67 |
| Sugar Pill | 22.71 | 40.29 | 28.14 | 32.43 |
Change scores from pre- to post-treatment/placebo were calculated for the primary outcome measures, the Selective Reminding Test Continuous Long-Term Retrieval (range 0-72; higher scores indicate better memory) and 7-24 Spatial Recall Test Total Learning (range 0-35; total correct across 5 learning trials are summed, with higher scores indicating better memory) scores. These measures are scores on a scale, rather than representing standard units. (NCT01054599)
Timeframe: 13 weeks
| Intervention | scores on a scale (Mean) | |
|---|---|---|
| 7-24 Spatial Recall Tests Learning Change Score | SRT Continuous Long-Term Retrieval Change Score | |
| Memantine | 1.00 | 4.38 |
| Sugar Pill | 1.78 | 8.11 |
16 reviews available for pilocarpine and Seizures
| Article | Year |
|---|---|
2DG and glycolysis as therapeutic targets for status epilepticus.
Topics: Deoxyglucose; Glucose; Glycolysis; Humans; Pilocarpine; Seizures; Status Epilepticus | 2023 |
Evolution of interictal activity in models of mesial temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pil | 2023 |
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure- Induced Neuronal Death.
Topics: Animals; Cell Death; Cytidine Diphosphate Choline; Glycerylphosphorylcholine; Muscarinic Agonists; N | 2018 |
Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Physical Conditioning, Animal; Pilocarpine; Seizu | 2017 |
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Temporal Lobe; | 2014 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
High-frequency oscillations and mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine | 2018 |
Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes; Penicillin G; Pentylenetetrazole; Pilocarp | 2010 |
Neuronal apoptosis after brief and prolonged seizures.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Dentate Gyrus; Disease Models, Animal; Kainic Acid; Neuro | 2002 |
New insights from the use of pilocarpine and kainate models.
Topics: Animals; Convulsants; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Mus | 2002 |
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor | 2002 |
Lithium-pilocarpine seizures as a model for lithium action in mania.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Inositol; Limbic System | 2007 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; | 2007 |
Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy.
Topics: Animals; Brain; Cholinergic Fibers; Disease Models, Animal; Mice; Pilocarpine; Rats; Seizures | 1989 |
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
1 trial available for pilocarpine and Seizures
| Article | Year |
|---|---|
Two decades of research towards a potential first anti-epileptic drug.
Topics: Animals; Disease Models, Animal; Humans; Pharmaceutical Preparations; Pilocarpine; Seizures; Status | 2021 |
755 other studies available for pilocarpine and Seizures
| Article | Year |
|---|---|
Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.
Topics: Animals; Gap Junctions; Hippocampus; Pilocarpine; Rats; Seizures; Status Epilepticus | 2021 |
Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy; E | 2021 |
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.
Topics: Animals; Brain; Disease Progression; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Lit | 2021 |
Proteins related to ictogenesis and seizure clustering in chronic epilepsy.
Topics: Animals; Cerebral Cortex; Cluster Analysis; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mic | 2021 |
The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.
Topics: CA1 Region, Hippocampal; Cholinergic Agents; Gene Deletion; GluK2 Kainate Receptor; Humans; Kainic A | 2022 |
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Male; Mice; Pilocarpine; Seizures; | 2021 |
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprote | 2021 |
Diclofenac sodium enhances the antiepileptic effect of levetiracetam in pilocarpine induced epileptic mice model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Convulsants; Di | 2021 |
MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; Neurons; Ne | 2022 |
Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model.
Topics: Animals; Female; Models, Theoretical; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Seizures | 2022 |
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures | 2022 |
Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kina | 2022 |
Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Epilepsy; Hippocampus; Mice; Pilocarpine; | 2022 |
Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures.
Topics: Animals; Anticonvulsants; Brain; Fatigue; Pilocarpine; Pyrrolidinones; Rats; Rodentia; Seizures; Syn | 2022 |
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Generalized; Hippocampus; Pilocarpin | 2022 |
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Glycogen; Mice; Pilocarp | 2022 |
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Treatment of pilocarpine-induced epileptic seizures in adult male mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Epilepsy; Humans; Male; Mice; Pilocarpine; Pioglit | 2022 |
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats.
Topics: Animals; Epilepsy; Hippocampus; Lithium; Matrix Metalloproteinases; Pilocarpine; Rats; Seizures; Tis | 2022 |
Bilateral optogenetic activation of inhibitory cells favors ictogenesis.
Topics: Animals; Epilepsy, Temporal Lobe; Mice; Optogenetics; Pilocarpine; Seizures; Status Epilepticus | 2022 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation | 2022 |
Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats.
Topics: Animals; Baclofen; Electric Stimulation; Evoked Potentials, Motor; Male; Muscle, Skeletal; Pilocarpi | 2023 |
Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice.
Topics: Animals; Dopamine; Epilepsy; Farnesol; Hippocampus; Mice; Neuroprotective Agents; Norepinephrine; Pi | 2022 |
Negative effects of brain regulatory T cells depletion on epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilo | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interl | 2022 |
Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Huma | 2022 |
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; Autophagy; Biotin; Dynorphins; Epilepsy; Green Fluorescent Prot | 2022 |
Effect of morphine administration after status epilepticus on epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Lithium; Morphine; Naloxone; Pilocarpine; Rats; Seizures; | 2022 |
Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Galectin 1; Hippocampus; Neuroprotective A | 2022 |
Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mice; Neurogenesis; Pilocarp | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.
Topics: Animals; Disease Models, Animal; Endurance Training; Epilepsy; Hippocampus; Humans; Pilocarpine; Rat | 2022 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hippocampus; Iridoids; Mice; Pilocarpine; Rats; R | 2023 |
Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus.
Topics: Allopurinol; Animals; Antioxidants; Ellagic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; S | 2023 |
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Astrocytes; Connexin 43; Connexins; Down-Regulation; Hippocampus; Pilocarpine; Rats; RNA, M | 2022 |
Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study.
Topics: Adult; Animals; Deep Brain Stimulation; Epilepsy; Gliosis; Hippocampus; Humans; Magnetic Resonance I | 2023 |
Hippocampal glucocorticoid receptors modulate status epilepticus severity.
Topics: Animals; Convulsants; Corticosterone; Female; Glucocorticoids; Hippocampus; Male; Mice; Pilocarpine; | 2023 |
Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus.
Topics: Anti-Inflammatory Agents; Eugenol; Hippocampus; Humans; Inflammasomes; Neuroinflammatory Diseases; N | 2023 |
Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus.
Topics: Animals; Hippocampus; Methionine Sulfoximine; Pilocarpine; Rats; Seizures; Taurine | 2023 |
Upregulation of SLITRK5 in patients with epilepsy and in a rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Neocortex; Pilocarp | 2023 |
Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model.
Topics: Animals; Epilepsy; Lithium; Molecular Docking Simulation; Nardostachys; Pilocarpine; Rats; Seizures; | 2023 |
Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus.
Topics: Aggression; Animals; Epilepsy; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epil | 2023 |
Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors.
Topics: Adenosine Kinase; Animals; Disease Progression; Epilepsy; Male; Pilocarpine; Rats; Rats, Sprague-Daw | 2023 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier.
Topics: Adenosine Triphosphate; Angiostatins; Animals; Blood-Brain Barrier; Epilepsy; Lithium; Phosphoglycer | 2023 |
Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus.
Topics: Animals; Astrocytes; Calcium; Epilepsy; Gliosis; Hippocampus; Pilocarpine; Rats; Seizures | 2023 |
Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats.
Topics: Animals; Chloral Hydrate; Hippocampus; MicroRNAs; Pilocarpine; Rats; Seizures; Status Epilepticus; V | 2023 |
Disrupted in Schizophrenia 1 Reverse Ectopic Migration of Neural Precursors in Mouse Hilus After Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Mice; Neurogenesis; Pilocarpine; Schizophrenia; Seizures; Status Epilepticus | 2023 |
The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress.
Topics: Animals; Endoplasmic Reticulum Stress; Epilepsy; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sp | 2023 |
Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2023 |
Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2023 |
N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model.
Topics: Animals; Anticonvulsants; Epilepsy; Male; N-Formylmethionine Leucyl-Phenylalanine; Peptides; Pilocar | 2023 |
The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Centella; Chemical and Drug Induced Liver Injury; Convulsant | 2023 |
EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications.
Topics: Animals; Disease Models, Animal; Epilepsy; Genetic Therapy; Hippocampus; Mice; Neurons; Pilocarpine; | 2023 |
Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Humans; Interleukin-6; Mice; Mi | 2023 |
Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin | 2023 |
Differential patterns of very high-frequency oscillations in two seizure types of the pilocarpine-induced TLE model.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Mice; Pilocarpine; Seizures | 2023 |
Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mefloquine; Neuropr | 2023 |
Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Epilepsy, Temporal Lobe; Interneurons; Male; Mice; Mi | 2019 |
Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model.
Topics: Animals; Disease Models, Animal; Evidence-Based Practice; Hippocampus; Pilocarpine; Rats; Rats, Spra | 2019 |
Calpain-dependent cleavage of GABAergic proteins during epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Calpain; Male; Membrane Proteins; Neurons; Pilocarpine; Rats; Rats | 2019 |
Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.
Topics: Animals; Cognitive Dysfunction; Dose-Response Relationship, Drug; Fruit; Male; Mice; Oxidative Stres | 2020 |
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Topics: Animals; Antibodies; Apoptosis; Autophagy; Disease Models, Animal; Epilepsy; Hippocampus; HMGB1 Prot | 2020 |
Ryanodine receptors drive neuronal loss and regulate synaptic proteins during epileptogenesis.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Hippocampus; Male; Neurons; Neuroprotective | 2020 |
The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Polarity; Disease Models, Animal; Ependymoglial Cells; Mice; Neural Stem Cells; Neurog | 2020 |
Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice.
Topics: Aggression; Animals; Cell Proliferation; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; | 2020 |
Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; GABAergic Neurons; Glutamate Decarboxylase | 2020 |
Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; G | 2020 |
Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.
Topics: Animals; Anticonvulsants; Cannabidiol; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Male | 2020 |
The Runx1/Notch1 Signaling Pathway Participates in M1/M2 Microglia Polarization in a Mouse Model of Temporal Lobe Epilepsy and in BV-2 Cells.
Topics: Animals; Cell Line; Cell Polarity; Core Binding Factor Alpha 2 Subunit; Epilepsy, Temporal Lobe; Gen | 2020 |
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Topics: Animals; Anticonvulsants; Azoles; Brain; Calcium Signaling; CHO Cells; Cricetulus; Disease Models, A | 2020 |
Changes of EEG spectra in rat brains with different patterns of dysplasia in response to pilocarpine-induced seizures.
Topics: Animals; Brain; Electroencephalography; Female; Gamma Rays; Male; Malformations of Cortical Developm | 2020 |
Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.
Topics: Animals; Hippocampus; Kainic Acid; Mice; ORAI1 Protein; Pilocarpine; Pyramidal Cells; Seizures | 2020 |
Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine; Rats; Seizures | 2020 |
Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility.
Topics: Animals; Brain; Hippocampus; Mice; Pilocarpine; Seizures; Status Epilepticus | 2022 |
The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures.
Topics: Actinin; Actins; Animals; Cell Movement; Convulsants; Dendritic Spines; Dentate Gyrus; Male; Neuroge | 2021 |
The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Boron Compounds; Cymenes; Disease Models, Animal | 2020 |
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Equilibrative Nucleoside Transporter 1; Glutamic Acid; Hi | 2020 |
Microglial G
Topics: Animals; Calcium Signaling; Cell Movement; Convulsants; Electroencephalography; G-Protein-Coupled Re | 2021 |
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Susceptibility; Gene Expression; | 2021 |
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Topics: Animals; Anticonvulsants; Benzyl Alcohols; Disease Models, Animal; Electroencephalography; Epilepsy, | 2021 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Ant | 2021 |
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Me | 2021 |
Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Drug Therapy, Combination; Epilepsy; Female; Mice; Phenobarbit | 2021 |
Maternal crack cocaine use in rats leads to depressive- and anxiety-like behavior, memory impairment, and increased seizure susceptibility in the offspring.
Topics: Animals; Anxiety; Cocaine-Related Disorders; Crack Cocaine; Epilepsy; Female; Male; Memory Disorders | 2021 |
Effects of acute seizures on cell proliferation, synaptic plasticity and long-term behavior in adult zebrafish.
Topics: Animals; Behavior, Animal; Cell Proliferation; Hippocampus; Neurogenesis; Neuronal Plasticity; Piloc | 2021 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation.
Topics: Animals; Anticonvulsants; Biomarkers; Hippocampus; Inflammation; Interleukin-1beta; Lacosamide; Male | 2021 |
Anti-epileptogenic effect of NRP2945 in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Convulsants; Epilepsy, Temporal Lobe; Male; Neu | 2021 |
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop | 2021 |
Limbic progesterone receptor activity enhances neuronal excitability and seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Neurons; Pilocarpine; Progesterone; | 2021 |
Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine-induced seizures in rats.
Topics: Animals; Astrocytes; Endothelial Cells; Hippocampus; Neuroinflammatory Diseases; Pilocarpine; Rats; | 2021 |
Tubulin β-III modulates seizure activity in epilepsy.
Topics: Adolescent; Adult; Animals; Child; Down-Regulation; Electroencephalography; Female; Hippocampus; Hum | 2017 |
VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology.
Topics: Animals; Astrocytes; Cells, Cultured; Dentate Gyrus; Hippocampus; Male; Pilocarpine; Rats; Rats, Spr | 2017 |
Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice.
Topics: Animals; Bromodeoxyuridine; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Female | 2017 |
Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cells, Cultured; Epilepsy; Flavones; Male; Matrix | 2017 |
Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy; Epilepsy | 2017 |
Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2 | 2017 |
Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Cholinergic Agents; Epilepsy; Humans; Mice; Mic | 2017 |
Inflammation in the developing rat modulates astroglial reactivity to seizures in the mature brain.
Topics: Animals; Astrocytes; Brain; Glial Fibrillary Acidic Protein; Inflammation; Lipopolysaccharides; Male | 2017 |
Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus.
Topics: Animals; Antigens, Nuclear; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Doublecor | 2017 |
EP2 receptor agonist ONO-AE1-259-01 attenuates pentylenetetrazole- and pilocarpine-induced seizures but causes hippocampal neurotoxicity.
Topics: Animals; Anticonvulsants; Dinoprostone; Hippocampus; Male; Mice; Neurons; Neurotoxicity Syndromes; P | 2017 |
Anticonvulsant Effect of Swertiamarin Against Pilocarpine-Induced Seizures in Adult Male Mice.
Topics: Age Factors; Animals; Anticonvulsants; Cell Survival; Dose-Response Relationship, Drug; Iridoid Gluc | 2017 |
The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Disease Models, Animal; Drug R | 2017 |
Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electrocorticography; Entorhinal | 2017 |
SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Dual-Specificity Phosphatases; Epilepsy; Gene Expression Regulation | 2017 |
Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique.
Topics: Algorithms; Animals; Electroencephalography; Epilepsy, Temporal Lobe; Mice; Pilocarpine; Seizures | 2017 |
Gamma-Decanolactone Improves Biochemical Parameters Associated with Pilocarpine-Induced Seizures in Male Mice.
Topics: Animals; Catalase; DNA Damage; Lactones; Male; Mice; Mutagenesis; Nitric Oxide; Oxidative Stress; Pi | 2018 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pe | 2018 |
DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Antioxidants; Diazepam; Disease Models, Animal; DNA Damage; Hi | 2018 |
Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Metformin; Pilocarp | 2018 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administrati | 2017 |
Volumetric response of the adult brain to seizures depends on the developmental stage when systemic inflammation was induced.
Topics: Animals; Brain; Inflammation; Lipopolysaccharides; Magnetic Resonance Imaging; Male; Pilocarpine; Ra | 2018 |
Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus.
Topics: Animals; Antagomirs; Disease Models, Animal; Hippocampus; Inflammation; Lithium Compounds; Male; Mic | 2018 |
Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cerebral Cortex; Cognition Disorders; Convulsants; | 2018 |
Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity.
Topics: Alopecia; Animals; Biophysics; Body Weight; Bronchoconstrictor Agents; Cell Line, Transformed; Disea | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; Muscarinic Agonists; Pilocarpine; Rat | 2018 |
Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia.
Topics: Animals; Axon Initial Segment; Axons; Disease Models, Animal; Disease Susceptibility; Electroencepha | 2018 |
High frequency oscillations in epileptic rodents: Are we doing it right?
Topics: Animals; Brain; Brain Waves; Male; Pilocarpine; Rats, Sprague-Dawley; Seizures; Signal Processing, C | 2018 |
Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis.
Topics: Animals; Atorvastatin; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Female; Male; M | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Brain Injuries; Cells, Cultured; Epilepsy; Gene E | 2018 |
Behavioral and biochemical effects of ethanol withdrawal in zebrafish.
Topics: Animals; Anxiety; Brain; Catalase; Darkness; Ethanol; Meta-Analysis as Topic; Models, Biological; Pi | 2018 |
Immunotherapy by targeting of VGKC complex for seizure control and prevention of cognitive impairment in a mouse model of epilepsy.
Topics: Animals; Antibodies; Cognitive Dysfunction; Disease Models, Animal; Humans; Immunotherapy; Lithium; | 2018 |
Effect of prenatal stress on ɑ5 GABA
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Gene Expression Regulation, Developmental | 2018 |
Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice.
Topics: Acute Disease; Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Coumarins; Cytokines; Enzyme Act | 2018 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; | 2019 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Enzyme Inhibitors; Humans; | 2018 |
Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner.
Topics: Animals; Anticonvulsants; Brain Waves; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; Lith | 2018 |
Alterations in mRNA expression of glutamate receptor subunits and excitatory amino acid transporters following pilocarpine-induced seizures in rats.
Topics: Animals; Disease Models, Animal; Hippocampus; Male; Pilocarpine; Rats, Wistar; Receptors, AMPA; Rece | 2018 |
Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries.
Topics: Animals; Apoptosis; Hippocampus; Inflammation; Lithium Chloride; Male; Memory Disorders; Oxidative S | 2018 |
Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hippocampus; Levetiracetam; Lith | 2018 |
Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice.
Topics: Animals; Anticonvulsants; Chitosan; Desiccation; Drug Compounding; Drug Liberation; Female; Male; Mi | 2018 |
The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures.
Topics: Action Potentials; Animals; Cell Differentiation; Cell Line; Disease Models, Animal; Glatiramer Acet | 2018 |
Neurochemical properties of neurospheres infusion in experimental-induced seizures.
Topics: Animals; Brain; Convulsants; Female; Male; Neural Stem Cells; Oxidative Stress; Pilocarpine; Rats; R | 2018 |
Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Epilepsy; Hippocamp | 2018 |
Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey.
Topics: Animals; Behavior, Animal; Case-Control Studies; Cerebral Cortex; Electroencephalography; Epilepsy; | 2018 |
Biochemical Changes Indicate Developmental Stage in the Hippocampal Formation.
Topics: Age Factors; Animals; Brain; Creatine; Disease Models, Animal; Hippocampus; Male; Pilocarpine; Rats, | 2019 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Ivabradine possesses anticonvulsant and neuroprotective action in mice.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Ivabradine; Male; Mice; Neuroprot | 2019 |
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cannabidiol; Disease Models, Animal; Epilepsy; Epilepsy, | 2019 |
The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity.
Topics: Animals; Blood Glucose; Blood-Brain Barrier; Hippocampus; Ion Channel Gating; Mice, Inbred C57BL; Ne | 2019 |
Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model.
Topics: Animals; Anticonvulsants; Benzoxazines; Disease Models, Animal; Endocannabinoids; Hippocampus; Lithi | 2019 |
Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy.
Topics: Animals; Cell Encapsulation; Cell Line; Drug Delivery Systems; Epilepsy; Glial Cell Line-Derived Neu | 2019 |
Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Iridoid Glucosides; Lithium; Mal | 2019 |
Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.
Topics: Animals; Dentate Gyrus; Hippocampus; Mice; Neurogenesis; Neuroprotection; Pilocarpine; Seizures | 2019 |
Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.
Topics: Animals; COP9 Signalosome Complex; Intracellular Signaling Peptides and Proteins; Maze Learning; Mem | 2019 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Tempor | 2019 |
(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.
Topics: Animals; Catechin; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; | 2019 |
Intranasal Delivery of Botulinum Neurotoxin A Protects against Hippocampal Neuron Death in the Lithium-Pilocarpine Rat Model.
Topics: Administration, Intranasal; Animals; Botulinum Toxins, Type A; Cell Death; Hippocampus; Lithium; Mal | 2019 |
Anticonvulsant and Neuroprotective Effects of Dexmedetomidine on Pilocarpine-Induced Status Epilepticus in Rats Using a Metabolomics Approach.
Topics: Animals; Anticonvulsants; Brain; Chromatography, Liquid; Dexmedetomidine; Disease Models, Animal; Hi | 2019 |
Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms.
Topics: Acetylcholinesterase; Animals; Cyclic GMP; Hippocampus; Male; Mice; Nitric Oxide; Nitric Oxide Synth | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2019 |
Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy.
Topics: Animals; Epilepsy; Excitatory Postsynaptic Potentials; Lipid A; Lipopolysaccharides; Male; Neurons; | 2019 |
Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat.
Topics: Animals; Antioxidants; Benzylamines; Injections, Intraperitoneal; Interleukin-1beta; Male; Pilocarpi | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway.
Topics: Animals; Anticonvulsants; Apocynaceae; Caspase 3; Digitoxigenin; Drugs, Chinese Herbal; Epilepsy; Hi | 2019 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
Targeting Seizure-Induced Neurogenesis in a Clinically Relevant Time Period Leads to Transient But Not Persistent Seizure Reduction.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Neural Stem Cells; Neu | 2019 |
Progesterone receptor activation regulates seizure susceptibility.
Topics: Animals; Female; Mifepristone; Norprogesterones; Pilocarpine; Progesterone; Rats; Rats, Sprague-Dawl | 2019 |
Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management.
Topics: Animals; Disease Models, Animal; Epilepsy; Fibrosis; Heart Diseases; Lithium Compounds; Male; Myocar | 2019 |
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Topics: Animals; Anticonvulsants; Behavior, Animal; Databases, Genetic; Electroencephalography; Enzyme Inhib | 2013 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats.
Topics: Adolescent; Adult; Animals; Axons; Case-Control Studies; Cytoplasm; Epilepsy, Temporal Lobe; Female; | 2013 |
Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels.
Topics: Acetylcholine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Entorhinal Cortex; Evoke | 2013 |
A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.
Topics: Animals; Apoptosis; Dynamins; Hippocampus; Male; Neurons; Neuroprotective Agents; Pilocarpine; Quina | 2013 |
Association of mitochondrial letm1 with epileptic seizures.
Topics: Adolescent; Adult; Animals; Brain; Calcium-Binding Proteins; Cation Transport Proteins; Child; Epile | 2014 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity.
Topics: Animals; Calbindin 2; Carrier Proteins; Cation Transport Proteins; Cell Count; Dendrites; Disease Mo | 2013 |
Neuronal synchrony and the transition to spontaneous seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Electroencephalography; Male; Neurons; Pilocarp | 2013 |
Pregabalin attenuates excitotoxicity in diabetes.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Blood Glucose; Cell Line; Diabetic Neuropathies; D | 2013 |
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; | 2013 |
Anticonvulsant screening of luteolin in four mouse seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2013 |
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Cannabinoids; Cannabis; Disease Models, Animal; Dose-R | 2013 |
Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy.
Topics: Animals; Antioxidants; Ascorbic Acid; Autophagy; Brain; Brain Injuries; Lipid Peroxidation; Male; Ma | 2013 |
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Neuro | 2013 |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents; Hippocampus; Interleukin-1beta; Male; Mice; Pentylenet | 2013 |
The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.
Topics: Animals; Brain; Cell Death; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Hippocamp | 2014 |
Additional antiepileptic mechanisms of levetiracetam in lithium-pilocarpine treated rats.
Topics: Animals; Anticonvulsants; Dinoprostone; Dopamine; Glutathione; Hippocampus; Interleukin-10; Levetira | 2013 |
Elevated expression of pleiotrophin in pilocarpine-induced seizures of immature rats and in pentylenetetrazole-induced hippocampal astrocytes in vitro.
Topics: Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytokines; | 2014 |
Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Fe | 2013 |
In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.
Topics: Animals; Anticonvulsants; Computer Simulation; Cornea; Dose-Response Relationship, Drug; Drug Design | 2013 |
Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex.
Topics: Animals; Down-Regulation; Enzyme Inhibitors; Frontal Lobe; Kainic Acid; Male; NG-Nitroarginine Methy | 2014 |
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Electroencephalography; Gabapentin; gamma- | 2013 |
Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures.
Topics: Animals; Insufflation; Male; Mossy Fibers, Hippocampal; Oxygen; Pilocarpine; Random Allocation; Rats | 2014 |
A locus on mouse Ch10 influences susceptibility to limbic seizure severity: fine mapping and in silico candidate gene analysis.
Topics: Animals; Chromosome Mapping; Chromosomes, Human, Pair 12; Chromosomes, Mammalian; Computational Biol | 2014 |
Neuroprotective effects of idebenone against pilocarpine-induced seizures: modulation of antioxidant status, DNA damage and Na(+), K (+)-ATPase activity in rat hippocampus.
Topics: Animals; Antioxidants; DNA Damage; Glutathione; Hippocampus; Male; Malondialdehyde; Neuroprotective | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.
Topics: Action Potentials; Animals; Convulsants; Flurothyl; Gene Deletion; Hippocampus; Long-Term Potentiati | 2014 |
Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Epilepsy, Temporal Lobe; Hippocampus; Mice, Inbred | 2014 |
Chronic intermittent hypoxic preconditioning suppresses pilocarpine-induced seizures and associated hippocampal neurodegeneration.
Topics: Animals; Apoptosis; Calcium; Hippocampus; Hypoxia; Ischemic Preconditioning; Male; Neurons; Pilocarp | 2014 |
NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus.
Topics: Animals; CA3 Region, Hippocampal; Capillaries; Carrier Proteins; Dentate Gyrus; Disease Models, Anim | 2014 |
Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
Topics: Animals; Anticonvulsants; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides; Peptides, C | 2014 |
Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy.
Topics: Animals; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Rats, Spra | 2014 |
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1.
Topics: Animals; Cyclohexanols; Male; Mice; Mice, Knockout; Muscarinic Agonists; Pilocarpine; Proliferating | 2014 |
Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Cognition Disorders; Comorbidity; Disease Model | 2014 |
Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.
Topics: Animals; Calcium Channels; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Molec | 2015 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures.
Topics: Animals; Behavior, Animal; Female; Male; Mice; Pilocarpine; Seizures; Triterpenes | 2014 |
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Chemistry Techniques, Synthetic; GABA U | 2014 |
The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
Topics: 4-Aminopyridine; Animals; Astrocytes; Bicuculline; Cell Survival; Cells, Cultured; Disease Models, A | 2014 |
Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats.
Topics: Animals; Coconut Oil; Convulsants; Diet, Ketogenic; Dietary Fats; Energy Intake; Male; Neuroprotecti | 2015 |
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Topics: Adult; Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Fl | 2014 |
5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Pilocarpine; Rats, | 2015 |
Critical role of canonical transient receptor potential channel 7 in initiation of seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Electric Stimulation; Electroencephalography; L | 2014 |
Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality.
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Electroshock; Mice; Mice, Tr | 2014 |
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Epoxide Hydrolases; Hippocampus; Inflammat | 2015 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cytochromes c; Enzyme Activation; Hippocampus; In Situ | 2014 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Dynamin I; Epilepsy, Temporal Lobe; Female | 2015 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate | 2014 |
Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model.
Topics: Animals; Benzamides; Cell Nucleus; Central Nervous System Agents; Cytoplasm; Dioxoles; Disease Model | 2014 |
Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice.
Topics: Animals; Anticonvulsants; Liposomes; Male; Mice; Nimodipine; Pilocarpine; Seizures; Stereotyped Beha | 2015 |
The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus.
Topics: Animals; Cognition Disorders; Lithium Compounds; Male; Oxidative Stress; Pentoxifylline; Pilocarpine | 2014 |
ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission.
Topics: Action Potentials; Adenosine; Adolescent; Adult; Animals; Anterior Temporal Lobectomy; Anticonvulsan | 2015 |
Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures.
Topics: Action Potentials; Animals; Disease Models, Animal; Hippocampus; Interneurons; Mice; Mice, Knockout; | 2015 |
The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Epilepsy; Male; Piloc | 2014 |
Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Cortex; Electroencephalography; Encepha | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA3 Region, Hippocampal; Cell Count; Dentate Gyrus; Fema | 2015 |
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; cdc42 GTP-Binding Protein; Disease Models, Anim | 2015 |
Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis.
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium Compounds; Male; Microelectrodes; Pilocarpine; | 2015 |
In vivo evaluation of anticonvulsant and antioxidant effects of phenobarbital microemulsion for transdermal administration in pilocarpine seizure rat model.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Emulsions | 2015 |
The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epi | 2015 |
Distinct EEG seizure patterns reflect different seizure generation mechanisms.
Topics: 4-Aminopyridine; Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Male | 2015 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocamp | 2015 |
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disea | 2015 |
State and parameter estimation of a neural mass model from electrophysiological signals during the status epilepticus.
Topics: Algorithms; Animals; CA1 Region, Hippocampal; Convulsants; Dentate Gyrus; Electroencephalography; El | 2015 |
[Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Topics: Animals; CA3 Region, Hippocampal; Epilepsy; Immunohistochemistry; Male; NAV1.2 Voltage-Gated Sodium | 2015 |
Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy.
Topics: Action Potentials; Animals; Brain Waves; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2015 |
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Topics: Animals; Calpain; Disease Models, Animal; Epilepsy; Hippocampus; Levetiracetam; Pilocarpine; Piracet | 2015 |
Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Topics: Adamantane; Animals; Anticonvulsants; Arginine; CHO Cells; Cricetulus; Dipeptides; Disease Models, A | 2015 |
Inflammation induced at different developmental stages affects differently the range of microglial reactivity and the course of seizures evoked in the adult rat.
Topics: Age Factors; Animals; Cytokines; Hippocampus; Inflammation; Inflammation Mediators; Male; Microglia; | 2015 |
Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway.
Topics: Animals; Dose-Response Relationship, Drug; Ghrelin; Hippocampus; Male; Mice; Mice, Knockout; Orexins | 2015 |
Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats.
Topics: Animals; Anticonvulsants; Epilepsy, Generalized; Hippocampus; Male; Pilocarpine; Rats, Sprague-Dawle | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
Topics: Action Potentials; Aminoquinolines; Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cells, Cu | 2015 |
Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Electrocorticography; Electrodes, Impl | 2015 |
Comparative immunohistochemical study of the effects of pilocarpine on the mossy cells, mossy fibres and inhibitory neurones in murine dentate gyrus.
Topics: Animals; Calbindin 2; Calcitonin Gene-Related Peptide; Dentate Gyrus; Hippocampus; Immunohistochemis | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus.
Topics: Animals; Calbindin 1; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Excitatory Post | 2015 |
Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Brain Chemistry; Convulsants; CREB-Binding Protein; Disease Models, Animal; Female; Immunob | 2015 |
Protein-caloric dietary restriction inhibits mossy fiber sprouting in the pilocarpine model of TLE without significantly altering seizure phenotype.
Topics: Animals; Caloric Restriction; Diet, Protein-Restricted; Disease Models, Animal; Electroencephalograp | 2015 |
Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Male; Mice; Piloca | 2015 |
Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus.
Topics: Animals; Anticonvulsants; Apoptosis; Benzodiazepines; Convulsants; Exploratory Behavior; GABA Agonis | 2015 |
Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate.
Topics: Animals; Anticonvulsants; Behavior, Animal; Coumaric Acids; Male; Mice; Motor Activity; Muscle Relax | 2015 |
Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Lentivirus; Male; Neurofibr | 2016 |
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; | 2015 |
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Lithium; | 2016 |
Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channels, L-Type; Formaldehyde; Hot Temperature; Male; | 2016 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Aci | 2016 |
Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to Autism Spectrum Disorder.
Topics: Animals; Anxiety; Association Learning; Autism Spectrum Disorder; Brain; Chromosome Deletion; Chromo | 2015 |
N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.
Topics: Animals; Antigens, Nuclear; Chronic Disease; Depressive Disorder; Disease Models, Animal; Epilepsy; | 2016 |
Relationship between seizure frequency and number of neuronal and non-neuronal cells in the hippocampus throughout the life of rats with epilepsy.
Topics: Animals; Cell Count; Hippocampus; Male; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Fac | 2016 |
Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Amiloride; Animals; Anticonvulsants; B | 2015 |
Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.
Topics: Animals; Exoribonucleases; GABAergic Neurons; Gene Expression Regulation; Hippocampus; Interneurons; | 2016 |
Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats.
Topics: Age Factors; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Perio | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain.
Topics: Animals; Brain; Brain Injuries, Traumatic; Calbindin 2; Glial Fibrillary Acidic Protein; Male; Neuro | 2016 |
Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures.
Topics: Animals; Anticonvulsants; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Male; M | 2016 |
Maternal seizures can affect the brain developing of offspring.
Topics: Animals; bcl-2-Associated X Protein; Blood Glucose; Female; Hippocampus; Male; Pilocarpine; Poly (AD | 2016 |
Synthesis of N-1', N-3'-disubstituted spirohydantoins and their anticonvulsant activities in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Molecular Struc | 2016 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A | 2016 |
Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; COS Cells; Cysteine; Mic | 2016 |
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus.
Topics: Animals; Hippocampus; Male; Nerve Degeneration; Neurons; Phlorhizin; Pilocarpine; Rats; Rats, Wistar | 2016 |
Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cinnamates; Depsides; Dose-Response Relationship, Drug; | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
The Anticonvulsant and Neuroprotective Effects of Oxysophocarpine on Pilocarpine-Induced Convulsions in Adult Male Mice.
Topics: Age Factors; Alkaloids; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice | 2017 |
The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Agonists; Dentate Gyrus; Disease Models | 2016 |
Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Cerebral Cortex; Cytokines; Electroencephalography | 2016 |
Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment.
Topics: Animals; Blood-Brain Barrier; Cell Death; Choline O-Acetyltransferase; Cognition; Cognitive Dysfunct | 2017 |
Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats.
Topics: Animals; Disease Models, Animal; Female; Motor Activity; Physical Conditioning, Animal; Pilocarpine; | 2016 |
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Topics: Adolescent; Adult; Animals; Behavior, Animal; Case-Control Studies; Child; Disease Models, Animal; D | 2016 |
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Convulsants; Epilepsy, Temporal Lobe; Gene Kno | 2017 |
Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model.
Topics: Animals; Astrocytes; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Estradio | 2017 |
PDI regulates seizure activity via NMDA receptor redox in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Ep | 2017 |
Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Membrane Glycoproteins | 2017 |
A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Calpain; Cerebral Cortex; Dipeptides; Disease Models, Animal; Dose-Respons | 2017 |
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lo | 2017 |
Amiloride delays the onset of pilocarpine-induced seizures in rats.
Topics: Amiloride; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2008 |
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response | 2008 |
Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy, Tem | 2008 |
Remote effects of focal hippocampal seizures on the rat neocortex.
Topics: Animals; Brain Mapping; Electric Stimulation; Electroencephalography; Female; Hippocampus; Image Pro | 2008 |
Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora).
Topics: Animals; Anticonvulsants; Flavonoids; Glucosides; Male; Phenols; Phenylethyl Alcohol; Phytotherapy; | 2009 |
Profound hypothermia determines the anticonvulsant and neuroprotective effects of swim stress.
Topics: Animals; Convulsants; Hippocampus; Hypothermia, Induced; Lithium Chloride; Male; Pilocarpine; Rats; | 2008 |
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; El | 2008 |
Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calbindin 2; Cell Death; Cholera Toxin; Disease Models, Animal; DNA-Binding Proteins; Elect | 2009 |
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept | 2009 |
Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat.
Topics: Analysis of Variance; Animals; Conditioning, Classical; Disease Models, Animal; Electroshock; Emotio | 2009 |
Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats.
Topics: Animals; Brain; Epilepsy, Temporal Lobe; Estrogens, Conjugated (USP); Female; Muscarinic Agonists; P | 2009 |
Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Disease Models, Animal; Enzyme Induction; Male; Neu | 2009 |
Long-term changes in dopamine-stimulated gene expression after single-day methamphetamine exposure.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain; Dopamine; Dop | 2009 |
Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor.
Topics: Animals; Apoptosis; Astrocytes; Cell Count; Cell Proliferation; Cells, Cultured; Hippocampus; Male; | 2009 |
Large differences in blood measures, tissue weights, and focal areas of damage 1 year after postseizure treatment with acepromazine or ketamine.
Topics: Acepromazine; Analysis of Variance; Animals; Blood Pressure; Brain; Disease Models, Animal; Dopamine | 2009 |
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted | 2009 |
Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Epilepsy; Male; Pilocarpine; Rats; Rats, Wistar; Seizures | 2009 |
The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals.
Topics: Animals; Brain; Catalase; Cell Death; Chickens; DNA Damage; DNA, Single-Stranded; Malondialdehyde; M | 2010 |
Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Hippocampus; Immunohistochemistry | 2009 |
The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Hippocampus; Lipid Peroxidation; Muscarinic Agonists; Neuroprotecti | 2009 |
Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biophysics; Blood Glucose; Brain Injuries; Co | 2009 |
Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Cell Death; Ghrelin; Hippocampus; Male; Neuroprotect | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
In vivo mapping of temporospatial changes in glucose utilization in rat brain during epileptogenesis: an 18F-fluorodeoxyglucose-small animal positron emission tomography study.
Topics: Animals; Brain; Epilepsy, Temporal Lobe; Fluorodeoxyglucose F18; Glucose; Male; Pilocarpine; Positro | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relation | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western | 2009 |
Does pilocarpine-induced epilepsy in adult rats require status epilepticus?
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Inflammatio | 2009 |
Behavioral and histological assessment of the effect of intermittent feeding in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Eating; Epileps | 2009 |
Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo.
Topics: Animals; Association Learning; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Gene E | 2010 |
Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice.
Topics: Analysis of Variance; Animals; Convulsants; Guanidines; Male; Mice; Nitric Oxide Synthase Type II; P | 2009 |
Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine.
Topics: Animals; Catalase; Chronic Disease; Epilepsy; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxida | 2009 |
Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage.
Topics: Animals; Behavior, Animal; Cognition; Female; Hippocampus; Learning; Mice; Neuroglia; Neurons; Piloc | 2009 |
Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat.
Topics: Aging; Animals; Brain Injuries; Cell Count; Cell Death; Hippocampus; Immunohistochemistry; Male; Neu | 2009 |
Behavioural and histological effects of preconditioning with lipopolysaccharide in epileptic rats.
Topics: Animals; Behavior, Animal; Epilepsy, Temporal Lobe; Hippocampus; Ischemic Preconditioning; Lipopolys | 2010 |
Interactive effect of excitotoxic injury and dietary restriction on neurogenesis and neurotrophic factors in adult male rat brain.
Topics: Animals; Brain; Caloric Restriction; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Techniq | 2009 |
Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Convulsants; Disease Models, Animal; Down-Regulation; Enzymes; Glutathione; G | 2010 |
Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures.
Topics: Animals; Chromatography, Thin Layer; Glutathione; Hippocampus; Male; Muscarinic Agonists; Oxidative | 2010 |
Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone.
Topics: Animals; Anticonvulsants; Buspirone; Catalase; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxid | 2010 |
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.
Topics: Analysis of Variance; Anesthetics, Dissociative; Animals; Biogenic Monoamines; Body Weight; Brain; B | 2009 |
Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine: quantitative and topographic elemental analysis of brain tissue.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Male; Neuroprotective Agents; Pilocarpine; Rats; R | 2010 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine.
Topics: Acetates; Acute Disease; Animals; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; | 2010 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalograp | 2009 |
Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lobe; Male; Pil | 2010 |
Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Choline O-Acetyltransferase; Male; Maze Learning; M | 2010 |
The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures.
Topics: alpha-Tocopherol; Animals; Catalase; Hippocampus; Lipid Peroxidation; Male; Oxidative Stress; Piloca | 2010 |
Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Convulsants; Drug Interaction | 2010 |
Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.
Topics: Animals; Brain; Male; Pilocarpine; Porphobilinogen Synthase; Rats; Rats, Wistar; Seizures; Sodium-Po | 2010 |
Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Cell Count; Chemokine CCL2; Dentate Gyrus; Endothelial | 2009 |
Effects of ubiquinone on hydroperoxide concentration and antioxidant enzymatic activities in the rat hippocampus during pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hippocamp | 2010 |
Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: implications for seizure blockade.
Topics: Analysis of Variance; Animals; Blotting, Western; Hippocampus; Immunohistochemistry; Male; Neuropept | 2010 |
Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies.
Topics: Animals; Epilepsy, Temporal Lobe; Muscarinic Agonists; Oxygen Consumption; Physical Conditioning, An | 2009 |
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.
Topics: Analysis of Variance; Animals; Antigens, CD; Bone Marrow Transplantation; Cell Movement; Disease Mod | 2010 |
Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo.
Topics: Animals; Cortical Synchronization; Electroencephalography; Electrooculography; Epilepsy; Interneuron | 2010 |
Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats.
Topics: Animals; Autoreceptors; Chromatography, Liquid; gamma-Aminobutyric Acid; Hippocampus; Male; Microdia | 2010 |
Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy.
Topics: Animals; Cell Count; Dentate Gyrus; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinas | 2010 |
Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Anxiety; E | 2010 |
Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Electroencephalography; GABA Agents; Hu | 2010 |
Synchrotron FTIR micro-spectroscopy study of the rat hippocampal formation after pilocarpine-evoked seizures.
Topics: Animals; Hippocampus; Lipid Peroxidation; Pilocarpine; Pyramidal Cells; Rats; Seizures; Spectroscopy | 2010 |
Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Post | 2010 |
Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
Topics: Animals; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Hindlimb; Hyperpolarizatio | 2010 |
Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Biogenic Monoamines; Dopamine; Hippocampus; Hydroxyindoleacetic Acid; Male; N | 2010 |
Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Epilepsy; Female; Male; Motor Activity; Pilocarpine; | 2010 |
Cholinergic regulation of striatal Nova mRNAs.
Topics: Animals; Antigens, Neoplasm; Corpus Striatum; Excitatory Amino Acid Agonists; Kainic Acid; Lithium C | 2010 |
[Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Humans; Interleukin 1 Receptor Antagonist Protein; I | 2010 |
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mossy Fibers, Hippocampal | 2010 |
Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Hippocampus; Male; Oxidative St | 2011 |
Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures.
Topics: Acetylcholinesterase; Animals; Hippocampus; Interleukin-1beta; Male; Pilocarpine; Rats; Rats, Wistar | 2011 |
Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity.
Topics: Adolescent; Adult; Albumins; Animals; Blood-Brain Barrier; Child, Preschool; Disease Models, Animal; | 2010 |
Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Brain Damage, Chronic; Hippocampus; Male; Mu | 2010 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbamates; Cell Line; Dipeptides; Disease Models, | 2010 |
Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system.
Topics: Animals; CA3 Region, Hippocampal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroe | 2010 |
Seizures during pregnancy modify the development of hippocampal interneurons of the offspring.
Topics: Age Factors; Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Count; Disease Models, Animal | 2010 |
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
Topics: Animals; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Mice, Knockout; N- | 2010 |
Lipoic acid increases glutathione peroxidase, Na+, K+-ATPase and acetylcholinesterase activities in rat hippocampus after pilocarpine-induced seizures?
Topics: Acetylcholinesterase; Animals; Antioxidants; Glutathione Peroxidase; Hippocampus; Male; Pilocarpine; | 2010 |
Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; Electric Stimulation Therapy; Hippocampus; Lithium Chloride; Male; | 2011 |
Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy.
Topics: Animals; Biomarkers; Epilepsy; GAP-43 Protein; Hippocampus; Immunohistochemistry; Male; Mice; Mice, | 2011 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats.
Topics: Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2010 |
Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy.
Topics: Alternative Splicing; Animals; Calcium; Dentate Gyrus; Epilepsy, Temporal Lobe; Exons; Large-Conduct | 2011 |
Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.
Topics: Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Gene Expression Regulati | 2010 |
X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury.
Topics: Animals; Brain; Brain Injuries; In Vitro Techniques; Male; Pilocarpine; Rats; Seizures; Spectrometry | 2011 |
Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures.
Topics: Animals; Blotting, Western; Caspases; Cell Death; Hippocampus; Male; Neuroprotective Agents; Pilocar | 2011 |
STEP regulation of seizure thresholds in the hippocampus.
Topics: Animals; Dentate Gyrus; Electroencephalography; Female; Hippocampus; Male; Mice; Mice, Knockout; Mus | 2011 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Dise | 2011 |
Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells.
Topics: Animals; Dendritic Spines; Hippocampus; Male; Neurons; Neuropeptides; Pilocarpine; Rats; Rats, Wista | 2012 |
Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures.
Topics: Animals; Blotting, Western; Cell Death; Convulsants; Diazoxide; Hippocampus; Neurons; Neuroprotectiv | 2011 |
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Disease Models, Animal; Electroencephalography; | 2011 |
Doxycycline protects against pilocarpine-induced convulsions in rats, through its antioxidant effect and modulation of brain amino acids.
Topics: Amino Acids; Animals; Antioxidants; Brain; Doxycycline; Free Radical Scavengers; Lipid Peroxidation; | 2011 |
Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.
Topics: Androstadienes; Animals; Decanoic Acids; Diazoxide; Epilepsy; Hydroxy Acids; Male; Malondialdehyde; | 2011 |
Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy.
Topics: Amino Acids; Animals; Carbamazepine; Convulsants; Drug Evaluation, Preclinical; Electroshock; Epilep | 2011 |
Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agen | 2011 |
Predator and restraint stress during gestation facilitates pilocarpine-induced seizures in prepubertal rats.
Topics: Animals; Animals, Newborn; Cats; Cholinergic Agents; Corticosterone; Female; Male; Pilocarpine; Pred | 2011 |
Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Glutamic Acid; Hippocampus; Male; Piloc | 2011 |
Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures.
Topics: Animals; Antigens, CD; Blood-Brain Barrier; Brain; Disease Models, Animal; Electroencephalography; F | 2011 |
Modulation of leukotriene D4 attenuates the development of seizures in mice.
Topics: Acetates; Animals; Cyclopropanes; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Leuko | 2011 |
A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.
Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Memb | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
β-Hydroxybutyrate increases the pilocarpine-induced seizure threshold in young mice.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Convulsants; Diet, Ketogenic; Ketone Bodies; Male; | 2012 |
Oxidative stress in rat striatum after pilocarpine-induced seizures is diminished by alpha-tocopherol.
Topics: alpha-Tocopherol; Animals; Behavior, Animal; Catalase; Lipid Peroxidation; Male; Neostriatum; Nitrit | 2011 |
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
Topics: Animals; Chi-Square Distribution; Circadian Rhythm; Disease Models, Animal; Electroencephalography; | 2011 |
Early physical exercise and seizure susceptibility later in life.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Disease Susceptibility; Epile | 2011 |
Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.
Topics: Animals; Avoidance Learning; Cell Count; Electroshock; Hippocampus; Male; Maze Learning; Nerve Degen | 2011 |
Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.
Topics: Amides; Analysis of Variance; Animals; Anticonvulsants; Chromatography, Liquid; Disease Models, Anim | 2011 |
Decreased CREB levels suppress epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyclic AMP Response Element Modulator; | 2012 |
Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Mice; Mice, Inbred Strains; Neur | 2012 |
Mapping a mouse limbic seizure susceptibility locus on chromosome 10.
Topics: Animals; Chromosome Mapping; Convulsants; Genetic Predisposition to Disease; Genotype; Limbic System | 2011 |
Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.
Topics: Animals; Disease Models, Animal; Ghrelin; Kainic Acid; Male; Oligopeptides; Peptides; Pilocarpine; R | 2011 |
Prenatal exposure to restraint or predator stresses attenuates field excitatory postsynaptic potentials in infant rats.
Topics: Animals; Corticosterone; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Gestational | 2011 |
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Antidepressive Agents; Behavior, Anima | 2011 |
The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Proliferation; Disease Models, Animal | 2012 |
Synchrotron radiation Fourier-transform infrared and Raman microspectroscopy study showing an increased frequency of creatine inclusions in the rat hippocampal formation following pilocarpine-induced seizures.
Topics: Animals; Creatine; Fourier Analysis; Hippocampus; Pilocarpine; Rats; Seizures; Spectrum Analysis, Ra | 2012 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cell Line, Tumor; Delayed Rectifier Potassium | 2012 |
Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; CA3 Region, Hippocampal; Dexamethasone; Dinoprostone; Diseas | 2012 |
Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Epilepsy, Temporal Lobe; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; | 2012 |
Change of presynaptic vesicle cycling in the hippocampus after status convulsion.
Topics: Age Factors; Animals; CA1 Region, Hippocampal; Female; Fluorescent Dyes; Humans; Lithium; Male; Neur | 2012 |
Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation.
Topics: Animals; Anticonvulsants; Glutamic Acid; Hippocampus; Male; Microdialysis; Neuropeptide Y; Pilocarpi | 2012 |
Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Excitatory Amino Acid Agonists; GABAergic Neurons; gamma- | 2012 |
Social behavior impairment in offspring exposed to maternal seizures in utero.
Topics: Animals; Anxiety; Convulsants; Epilepsy, Tonic-Clonic; Female; Male; Pilocarpine; Pregnancy; Pregnan | 2012 |
Consequences of pilocarpine-induced status epilepticus in immunodeficient mice.
Topics: Animals; Brain; Cell Count; Cell Death; Glutamic Acid; Mice; Mice, Nude; Neurons; Pilocarpine; Proto | 2012 |
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Excitatory Amino Acid Transporter 2; Hippocampus; Male; Mice; Mice, Transg | 2012 |
The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Epilepsy; Flavonoids; Lipid Peroxidation; Male; Neuroprotective | 2012 |
Differential patterns of synaptotagmin7 mRNA expression in rats with kainate- and pilocarpine-induced seizures.
Topics: Animals; Kainic Acid; Male; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Rats; Rats, Wi | 2012 |
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression.
Topics: Animals; Carrier Proteins; Homer Scaffolding Proteins; Male; Pilocarpine; Rats; Rats, Wistar; Recept | 2012 |
New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction.
Topics: Animals; Animals, Newborn; Cytoplasmic Granules; Dentate Gyrus; Doublecortin Domain Proteins; Epilep | 2012 |
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Convulsants; Disease Susceptibility; Down-Regulation; I | 2012 |
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele | 2012 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agoni | 2012 |
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Topics: Animals; Brain; Cell Size; Gene Deletion; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Mi | 2012 |
Anticonvulsant effect of phytol in a pilocarpine model in mice.
Topics: Animals; Anticonvulsants; Male; Mice; Phytol; Pilocarpine; Seizures; Status Epilepticus; Survival Ra | 2012 |
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.
Topics: Animals; Anticholesteremic Agents; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electro | 2012 |
Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats.
Topics: Animals; Aspirin; Cell Death; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2012 |
Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats.
Topics: Action Potentials; Animals; Electroencephalography Phase Synchronization; Hippocampus; Male; Nerve N | 2012 |
Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Convulsants; Humans; Immunohistochemistry; In Situ Nic | 2012 |
Remodeling of hippocampal network in pilocarpine-treated mice expressing synaptopHluorin in the mossy fiber terminals.
Topics: Animals; Convulsants; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Mice; Mice, Inb | 2012 |
Anticonvulsive and antioxidant effects of curcumin on pilocarpine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Curcumin; Glutathione; Lipid Peroxidation; Male; Malondialde | 2012 |
Cannabidivarin is anticonvulsant in mouse and rat.
Topics: Animals; Anticonvulsants; Cannabinoids; Cannabis; Disease Models, Animal; Female; Hippocampus; In Vi | 2012 |
Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Corticosterone; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Seiz | 2012 |
Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Microscopy, Fluorescenc | 2012 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
A strength exercise program in rats with epilepsy is protective against seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonists; Muscle F | 2012 |
Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1.
Topics: Animals; Axons; Cell Death; Cell Survival; Data Interpretation, Statistical; Female; Galectin 1; Imm | 2012 |
Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure.
Topics: Animals; Cell Death; Cell Proliferation; Chelating Agents; Clioquinol; Dentate Gyrus; Doublecortin P | 2012 |
Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; CA3 Region, Hippocampal; Caspase 3; Gene Expression | 2013 |
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.
Topics: Animals; CA1 Region, Hippocampal; Cell Death; Long-Term Potentiation; Male; Mice; Mice, 129 Strain; | 2013 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats.
Topics: Animals; Anterior Thalamic Nuclei; Electric Stimulation Therapy; Epilepsy; Male; Pilocarpine; Rats; | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death.
Topics: Acetophenones; Animals; Cell Death; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocam | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diphosphonates; Injections, Intraventricular; Lipos | 2013 |
Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice.
Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gu | 2013 |
Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains.
Topics: Age Factors; Animals; Anticonvulsants; Case-Control Studies; Cell Count; Disease Models, Animal; Dru | 2013 |
Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calc | 2002 |
Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Hippocampus; Humans; Neuropeptide Y; Organ Culture Techn | 2002 |
Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain; Caspase 3; Caspases; Disease Models, Ani | 2002 |
Structural and functional asymmetry in the normal and epileptic rat dentate gyrus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Electrophysiology; Excitatory Amino Acid | 2002 |
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Model | 2003 |
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.
Topics: Action Potentials; Animals; Disease Susceptibility; Mice; Mice, Knockout; Nerve Fibers; Neural Condu | 2002 |
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; | 2003 |
The brain matrix and multifocal brain damage following a single injection of ketamine in young adult rats: conspicuous changes in old age.
Topics: Acepromazine; Age Factors; Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Ketamine; | 2002 |
Working memory and reference memory in adult rats following limbic seizures induced at 21 or 90 days of age.
Topics: Age Factors; Animals; Female; Limbic System; Lithium Chloride; Male; Maze Learning; Memory, Short-Te | 2002 |
Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures.
Topics: Animals; Axons; Dendrites; Hippocampus; Interneurons; Male; Pilocarpine; Pyramidal Cells; Rats; Rats | 2003 |
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
Topics: Animals; Apomorphine; Body Temperature; Cerebral Cortex; Dopamine Agonists; Dose-Response Relationsh | 2003 |
[Expressions of GDNF, GDNFR alpha and Ret proteins in the brain of rats with seizures induced by pilocarpine].
Topics: Animals; Brain; Cerebral Cortex; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derive | 2003 |
Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy.
Topics: Animals; Blood Glucose; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Epilepsy; Physical | 2003 |
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Disease Models, Animal; Endocannabinoids; | 2003 |
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chroma | 2003 |
Central excitatory and depressant effects of pilocarpine in rats and mice.
Topics: Animals; Central Nervous System Stimulants; Mice; Pilocarpine; Rats; Seizures | 1963 |
Effects of autonomic agents, alone and in combination with antiepileptic drugs, on electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Atropine; Autonomic Agents; Electroshock; Methacholine Compounds; Neostigm | 1963 |
STUDIES OF SUSTAINED HYPONATREMIA DUE TO CENTRAL NERVOUS SYSTEM INFECTION.
Topics: Alcohols; Anti-Bacterial Agents; Brain Abscess; Brain Diseases; Drug Therapy; Ethanol; Humans; Hydro | 1964 |
Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development.
Topics: Animals; Animals, Newborn; Brain; Female; Gamma Rays; Male; Pilocarpine; Pregnancy; Prenatal Exposur | 2003 |
Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility.
Topics: Amino Acid Transport System X-AG; Animals; Cell Separation; Convulsants; Dentate Gyrus; Disease Mode | 2004 |
Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electric Stimulation Therapy; Electroence | 2004 |
Detrimental effects of the ketogenic diet on cognitive function in rats.
Topics: Animals; Brain; Cognition; Diet; Lithium; Male; Maze Learning; Memory; Pilocarpine; Rats; Rats, Spra | 2004 |
A comparative study of the anticonvulsant effect of the N-substituted 5,5-diallylbarbiturates and 5,5-diphenylhydantoins.
Topics: Anticonvulsants; Barbiturates; Humans; Hydantoins; Phenytoin; Pilocarpine; Seizures | 1951 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cycloprop | 2004 |
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippoca | 2004 |
Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopam | 2004 |
Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry.
Topics: Alternative Splicing; Animals; Brain-Derived Neurotrophic Factor; Calcium; Calcium Channel Blockers; | 2004 |
Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cytarabine; Disease M | 2004 |
Strain differences affect the induction of status epilepticus and seizure-induced morphological changes.
Topics: Animals; Cell Count; Hippocampus; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, | 2004 |
The impact of genetic background on neurodegeneration and behavior in seizured mice.
Topics: Animals; Cell Death; Convulsants; Crosses, Genetic; Exploratory Behavior; Genetic Predisposition to | 2004 |
Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices.
Topics: Animals; Cell Survival; Epilepsy; Functional Laterality; Lithium; Male; Nerve Degeneration; Neurons; | 2004 |
Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Dentate Gyrus; Disease Models, Anim | 2004 |
Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants.
Topics: Aconitate Hydratase; Adenosine Triphosphate; Animals; Astrocytes; Cerebral Cortex; Citrates; Convuls | 2004 |
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
Topics: Animals; Biological Transport; Brain-Derived Neurotrophic Factor; Cell Compartmentation; Convulsants | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypote | 2004 |
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats.
Topics: Aggression; Animals; Animals, Newborn; Behavior, Animal; Cell Count; Cell Death; Cells, Cultured; El | 2004 |
Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures.
Topics: Animals; Cell Count; Epilepsy; Genes, fos; Hippocampus; Immunohistochemistry; Interneurons; Muscarin | 2004 |
Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Datura stramonium; Gelsemium; Lithium; Phytotherapy; | 2004 |
Alpha2-adrenergic inhibition prevents the accompanied anticonvulsant effect of swim stress on behavioral convulsions induced by lithium and pilocarpine.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Lithium; Male; Mifepristone; Naloxone; Piloc | 2004 |
Carbamazepine enhances discriminative memory in a rat model of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Discrimination Learning; Disease Models, Animal; Drug Ad | 2004 |
Lithium ion "cyclotron resonance" magnetic fields decrease seizure onset times in lithium-pilocarpine seized rats.
Topics: Analysis of Variance; Animals; Cyclotrons; Disease Models, Animal; Dose-Response Relationship, Drug; | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures.
Topics: Acute Disease; Animals; Anticonvulsants; Biogenic Monoamines; Citalopram; Dopamine; Dopamine Antagon | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; | 2004 |
Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis".
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Death; Cognition Disorders; | 2004 |
Anticonvulsant activity of ginseng on seizures induced by chemical convulsants.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Administration | 2005 |
Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Calcitriol; Calcium; Cell Proliferation; Dihydrox | 2005 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Cell Count; Disease Models, Animal; Entorhinal Cortex; Epilepsy, | 2005 |
Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Disease Models, Animal; Elec | 2005 |
Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transp | 2005 |
Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures.
Topics: Animals; Brain; Conditioning, Psychological; Fear; Male; Pilocarpine; Rats; Rats, Wistar; Seizures | 2005 |
Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine.
Topics: Animals; Disease Models, Animal; Female; Lithium; Male; Muscarinic Agonists; Pilocarpine; Rats; Seiz | 2005 |
The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2005 |
Anticonvulsant activity of androsterone and etiocholanolone.
Topics: 4-Aminopyridine; Androsterone; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; D | 2005 |
Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocampus; Levetiracetam; Male; Mic | 2005 |
Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis.
Topics: Action Potentials; Animals; Cell Count; Evoked Potentials; Hippocampus; Male; Neural Inhibition; Neu | 2005 |
Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats.
Topics: Acetylcholinesterase; Animals; Dentate Gyrus; Disease Models, Animal; Male; Mossy Fibers, Hippocampa | 2005 |
Glutamate receptor antagonists and growth factors modulate dentate granule cell neurogenesis in organotypic, rat hippocampal slice cultures.
Topics: Animals; Cell Differentiation; Dentate Gyrus; Epidermal Growth Factor; Excitatory Amino Acid Antagon | 2005 |
Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Blotting, Northern; Brain; Bromodeoxyuridine; CD11b Anti | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
Pilocarpine-induced seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Disease Susceptibility; Female; Immunohistochemistry; Maternal Exposure; Methylazoxymethano | 2005 |
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Estrogens; Estrous Cycle; Fema | 2005 |
Extreme obesity in female rats following prepuberal induction of lithium-pilocarpine seizures and a single injection of acepromazine.
Topics: Acepromazine; Animals; Body Weight; Chlorpromazine; Convulsants; Dopamine Antagonists; Female; Lithi | 2005 |
Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Behavior, Animal; Calcium Channel Blockers; Catalase; Corpus Striatum; Lipid | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; El | 2005 |
Congenital brain dysplasias of different genesis can differently affect susceptibility to pilocarpine- or kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Brain Diseases; Convulsants; Dose-Response Relationship, Drug; Electroenc | 2005 |
Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures.
Topics: Afferent Pathways; Animals; Calbindins; Cation Transport Proteins; Cell Count; Disease Models, Anima | 2005 |
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Topics: Animals; Antiporters; Bicuculline; Brain; Chloride-Bicarbonate Antiporters; Convulsants; Dentate Gyr | 2006 |
Weak, physiologically patterned magnetic fields do not affect maze performance in normal rats, but disrupt seized rats normalized with ketamine: possible support for a neuromatrix concept?
Topics: Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electromagnetic Fields; Ketami | 2006 |
Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brai | 2006 |
Seizures accelerate functional integration of adult-generated granule cells.
Topics: Animals; Animals, Newborn; Cell Division; Crosses, Genetic; Dendrites; Female; Green Fluorescent Pro | 2006 |
Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Female; Gestational Age; Magnetic R | 2006 |
Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Benzimidazoles; B | 2006 |
[Effects and consequence of recurrent seizures of neonatal rat on the hippocampal neurogenesis].
Topics: Age Factors; Animals; Animals, Newborn; Bromodeoxyuridine; Hippocampus; Neurogenesis; Pilocarpine; R | 2006 |
Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat.
Topics: Animals; Female; Male; Physical Conditioning, Animal; Physical Exertion; Pilocarpine; Rats; Rats, Wi | 2006 |
Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain; Chemical Warfare Agents; Cholin | 2006 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response | 2006 |
Consequences of pilocarpine-induced recurrent seizures in neonatal rats.
Topics: Animals; Animals, Newborn; Antimetabolites; Benzoxazines; Brain; Bromodeoxyuridine; Cell Proliferati | 2007 |
Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus.
Topics: Amines; Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2006 |
Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus.
Topics: Analgesics, Opioid; Animals; Antimanic Agents; Dopamine Antagonists; Haloperidol; Lithium Chloride; | 2006 |
Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures.
Topics: Animals; Behavior, Animal; Cyclosporine; Male; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wist | 2007 |
Preferential neuron loss in the rat piriform cortex following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Cerebral Cortex; Cholecystokinin; Disease Models, Animal; Immunohistochemistry; | 2007 |
Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death.
Topics: Analysis of Variance; Animals; Caspase 8; Caspase 9; Cell Count; Cell Death; Disease Models, Animal; | 2007 |
Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Catalase; Glutathione; Levetiracetam; Lipid Peroxidat | 2007 |
Gene expression changes after seizure preconditioning in the three major hippocampal cell layers.
Topics: Animals; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Amplification; Gene Ex | 2007 |
Use of chromosome substitution strains to identify seizure susceptibility loci in mice.
Topics: Animals; Chromosomes; Genetic Predisposition to Disease; Genetic Techniques; Male; Mice; Mice, Inbre | 2007 |
Effect of interictal spikes on single-cell firing patterns in the hippocampus.
Topics: Action Potentials; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Flurot | 2007 |
The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures.
Topics: Animals; Behavior, Animal; Chelating Agents; Disease Models, Animal; Drug Interactions; Edetic Acid; | 2007 |
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Male; Muscarinic Agonist | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Changes in vesicular transporters for gamma-aminobutyric acid and glutamate reveal vulnerability and reorganization of hippocampal neurons following pilocarpine-induced seizures.
Topics: Animals; GABA Plasma Membrane Transport Proteins; Hippocampus; Male; Neural Pathways; Neurons; Piloc | 2007 |
Anti-glutamatergic effect of riluzole: comparison with valproic acid.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Posts | 2007 |
Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Dose-Response Relationship, Drug; Hippocampus; Lipid | 2007 |
Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.
Topics: Animals; Astrocytes; Brain; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix P | 2007 |
Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Brain; Enzyme Inhibitors; Lithium Compounds; Male; | 2008 |
Inflammation exacerbates seizure-induced injury in the immature brain.
Topics: Acute Disease; Animals; Animals, Newborn; Body Temperature; Brain; Cell Count; Disease Models, Anima | 2007 |
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Count; Disease Models, Animal; Electroencephalography; Epi | 2008 |
Enhanced mortality of rat pups following inductions of epileptic seizures after perinatal exposures to 5 nT, 7 Hz magnetic fields.
Topics: Animals; Convulsants; Death, Sudden; Electromagnetic Fields; Female; Hippocampus; Lithium; Nitric Ox | 2007 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxygl | 2007 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dop | 2008 |
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus.
Topics: Animals; Blood Vessels; Cell Death; Convulsants; Enzyme-Linked Immunosorbent Assay; Hippocampus; Imm | 2008 |
Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Electric Stimulation; Electroencephalogra | 2008 |
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Capillaries; | 2008 |
Neuroprotective actions of vitamin C related to decreased lipid peroxidation and increased catalase activity in adult rats after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Catalase; Hippocampus; Lipid Peroxidation; M | 2008 |
Changes of cortical epileptic afterdischarges after status epilepticus in immature rats.
Topics: Aging; Animals; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy | 2008 |
Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
Topics: Animals; Cell Death; Ceramides; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid A | 2008 |
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Topics: Acetylcholine; Acetylcholinesterase; Alternative Splicing; Animals; Chronic Disease; Convulsants; El | 2008 |
Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Drug | 2008 |
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capill | 2008 |
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relati | 2008 |
Chemoconvulsant model of chronic spontaneous seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroshock; Excitatory Amino Acid Agonists; Kai | 2005 |
Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.
Topics: Amino Acids; Animals; Anticonvulsants; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Neurot | 2008 |
Homozygote inositol transporter knockout mice show a lithium-like phenotype.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Inositol; Lithium Compounds; Mice; Mice, Inb | 2008 |
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.
Topics: Animals; Benzamides; Blotting, Western; Brain Injuries; CD40 Antigens; Central Nervous System Diseas | 2008 |
The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model.
Topics: Animals; Blotting, Western; Brain; Calcium-Binding Proteins; Extracellular Matrix Proteins; Image Pr | 2008 |
Non-specificity of the mouse writhing test.
Topics: Acetates; Aminopyrine; Analgesics; Animals; Biological Assay; Bradykinin; Cyclazocine; Dextropropoxy | 1967 |
Cholinomimetics produce seizures and brain damage in rats.
Topics: Amygdala; Animals; Bethanechol; Bethanechol Compounds; Brain; Brain Diseases; Carbachol; Hippocampus | 1983 |
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phospha | 1983 |
Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; H | 1984 |
Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis.
Topics: Animals; Brain; Brain Diseases; Cholinergic Fibers; Disease Models, Animal; Electroencephalography; | 1984 |
Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentia | 1983 |
Up-regulation of trkB mRNA expression in the rat striatum after seizures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Gene Expression; Male; Nerve Growth Fac | 1995 |
Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Situ Hybridization; Male; Nerve Growth Fa | 1995 |
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Drug Synergism; Injections, Intraperitoneal; Kainic A | 1995 |
Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats.
Topics: Amphetamines; Animals; Cholinergic Agents; Drug Synergism; Inositol; Lithium; Male; Pilocarpine; Rat | 1995 |
Susceptibility of Flinders sensitive and resistant rats to pharmacologically induced seizures.
Topics: Animals; Drug Resistance; Male; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Rats, Spragu | 1995 |
Early genital stimulation of rats lowers limbic seizure latencies for females but increases latencies for males.
Topics: Animals; Animals, Newborn; Arousal; Electroencephalography; Female; Genitalia, Female; Genitalia, Ma | 1995 |
Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla.
Topics: Animals; Differential Threshold; Earth, Planet; Limbic System; Lithium; Magnetics; Male; Pilocarpine | 1995 |
Pilocarpine-induced convulsions in rats: evidence for muscarinic receptor-mediated activation of locus coeruleus and norepinephrine release in cholinolytic seizure development.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Locu | 1993 |
Long-term behavioral deficits following pilocarpine seizures in immature rats.
Topics: Animals; Behavior, Animal; Electroencephalography; Hippocampus; Male; Pilocarpine; Rats; Rats, Sprag | 1994 |
Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Complex Partial; | 1995 |
Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electro | 1995 |
High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chromatography, Gas; Glucose; Injection | 1994 |
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Int | 1993 |
Behavioral evidence for the existence of two pools of cellular inositol.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Hypernatremia; Hyponatremia; Inositol; | 1994 |
Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Injections, Intraperitoneal; Mice; Naltrexone; Piloca | 1994 |
The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Grooming; Limbic System; Locomotion; Male | 1994 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Di | 1993 |
Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures.
Topics: Acepromazine; Animals; Diencephalon; Lithium; Male; Muscarinic Agonists; Necrosis; Pilocarpine; Rats | 1994 |
Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine.
Topics: Animals; Anisomycin; Cerebral Ventricles; Cycloheximide; Electroencephalography; Hippocampus; Inject | 1994 |
Effects of dopamine D3 receptor agonists on pilocarpine-induced limbic seizures in the rat.
Topics: Animals; Apomorphine; Dopamine Agents; Ergolines; Injections; Limbic System; Male; Nucleus Accumbens | 1994 |
Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory.
Topics: Animals; Avoidance Learning; Brain Damage, Chronic; Brain Mapping; Conditioning, Classical; Dose-Res | 1994 |
Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Electrophysiology; Evoked Potentials; Hippocampus; In Vit | 1994 |
Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine.
Topics: Animals; Cerebral Cortex; Diazepam; Dizocilpine Maleate; Hippocampus; Lithium; Male; Pilocarpine; Ra | 1994 |
Loss of GABAA receptors during partial status epilepticus.
Topics: Animals; Electrophysiology; Epilepsia Partialis Continua; Kinetics; Lithium Chloride; Male; Muscimol | 1994 |
Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures.
Topics: Animals; Behavior, Animal; Electroencephalography; Hippocampus; Male; Neurons; Pilocarpine; Rats; Ra | 1994 |
Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Injections, Intraventricular; Male; Mice; Parasympatholytics | 1994 |
Clozapine inhibits limbic system kindling: implications for antipsychotic action.
Topics: Acetylcholine; Amygdala; Animals; Antipsychotic Agents; Clozapine; Dopamine; Drug Interactions; Elec | 1993 |
Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal D2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine; Dopamine Agents; Dopa | 1993 |
Seizure promotion by D1 agonists does not correlate with other dopaminergic properties.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Enz | 1993 |
Maintained hypersexuality between male rats following chronically induced limbic seizures: implications for bisexuality in complex partial epileptic seizures.
Topics: Animals; Bisexuality; Hippocampus; Limbic System; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Se | 1994 |
Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats.
Topics: Aging; Animals; Brain; Inositol; Inositol Phosphates; Male; Neurons; Pilocarpine; Rats; Rats, Wistar | 1993 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Sy | 1993 |
Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: implications for early brain injuries.
Topics: Animals; Brain Injuries; Limbic System; Lithium; Male; Memory; Memory Disorders; Memory, Short-Term; | 1993 |
Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME.
Topics: Animals; Arginine; Dizocilpine Maleate; Drug Synergism; Male; Mice; Mice, Inbred Strains; NG-Nitroar | 1993 |
Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Topics: Acepromazine; Animals; Body Temperature Regulation; Brain Injuries; Chlorides; Hypothermia; Limbic S | 1993 |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates; | 1993 |
Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures.
Topics: Animals; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry | 1993 |
MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.
Topics: Animals; Atropine; Diazepam; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Limbic Sys | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Topics: Acetylcholine; Aggression; Animals; Association Learning; Avoidance Learning; Brain; Brain Damage, C | 1993 |
Association between intermale social aggression and cellular density within the central amygdaloid nucleus in rats with lithium/pilocarpine-induced seizures.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Lithium; Male; Muscarinic Agonists; Neuroglia; Neur | 1995 |
Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: modulation by lithium.
Topics: Animals; Antimanic Agents; Base Sequence; Cerebral Cortex; Circadian Rhythm; DNA; Electroencephalogr | 1995 |
A comparison of the ability of myo-inositol and epi-inositol to attenuate lithium-pilocarpine seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Injections, Intraperitoneal; Injections, Intraventricu | 1996 |
7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Male; Mice; Mice, Inbred St | 1995 |
Decreased time constant in hippocampal dentate granule cells in pilocarpine-treated rats with progressive seizure frequencies.
Topics: Animals; Dentate Gyrus; Electric Stimulation; Electrophysiology; Evoked Potentials; In Vitro Techniq | 1996 |
Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino | 1995 |
Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats.
Topics: Animals; Cerebral Cortex; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Male; Neuronal | 1996 |
Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury.
Topics: Acetates; Amines; Animals; Anticonvulsants; Appetitive Behavior; Brain Damage, Chronic; Cholinergic | 1996 |
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
Topics: Animals; Convulsants; Electroshock; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Ma | 1996 |
Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures.
Topics: Animals; Brain; Epilepsy; Female; Hippocampus; Interneurons; Limbic System; Male; Pilocarpine; Rats; | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cholinergic Agonists; DNA Probes; Elec | 1997 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Ac | 1997 |
MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.
Topics: Animals; Brain Damage, Chronic; Dizocilpine Maleate; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; | 1997 |
Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Kainic Acid; Lithium; Pilocarpi | 1997 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excita | 1996 |
The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine.
Topics: Animals; Behavior, Animal; Brain; Coloring Agents; Electroencephalography; Evans Blue; Excitatory Am | 1997 |
Effects of pilocarpine and kainate-induced seizures on N-methyl-D-aspartate receptor gene expression in the rat hippocampus.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Aci | 1997 |
Lithium-pilocarpine status epilepticus in the immature rabbit.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Hippocampus; Lithium Carbonate; Neur | 1997 |
Seizure-related changes in the glutamate R2 and R5 receptor genes expression in the rat hippocampal formation.
Topics: Animals; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Situ Hybridizat | 1997 |
Proconvulsive effect of vasopressin; mediation by a putative V2 receptor subtype in the central nervous system.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Brain; Deamino Arginine Va | 1997 |
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Topics: Aging; Animals; Brain Chemistry; Electroencephalography; Excitatory Amino Acid Agonists; Extracellul | 1997 |
NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis.
Topics: Animals; Anticonvulsants; Atropine; Convulsants; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; H | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Fos-like immunoreactivity after status epilepticus and spontaneous seizures in rats.
Topics: Animals; Brain; Brain Mapping; Gene Expression; Male; Muscarinic Agonists; Pilocarpine; Proto-Oncoge | 1996 |
Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain; Brain Injuries; Disease Models, Animal; Electroshoc | 1997 |
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.
Topics: Animals; Behavior, Animal; Disease Susceptibility; Kainic Acid; Ligands; Mice; Mice, Knockout; Musca | 1997 |
Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats.
Topics: Animals; Atropine; Brain Diseases; Lithium; Male; Nimodipine; Pilocarpine; Rats; Rats, Wistar; Seizu | 1997 |
Mapping of cerebral metabolic activation in three models of cholinergic convulsions.
Topics: Animals; Autoradiography; Blood Pressure; Body Temperature; Brain Chemistry; Brain Mapping; Cholines | 1998 |
Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 1998 |
Augmentation of lithium's behavioral effect by inositol uptake inhibitors.
Topics: Animals; Depsipeptides; Drug Synergism; Fucose; Injections, Intraventricular; Inositol; Lithium; Mal | 1998 |
Ventricular dilation over several weeks following induction of excitotoxic (systemic lithium/pilocarpine) lesions: potential role of damage to the substantia nigra reticulata.
Topics: Animals; Atrophy; Brain; Cerebral Ventricles; Lithium; Male; Nerve Degeneration; Neurotoxins; Piloca | 1998 |
Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.
Topics: Animals; Behavior, Animal; Brain Injuries; Electroencephalography; Lithium; Male; Neurons; Pilocarpi | 1998 |
"Subclinical" dosages of lithium and pilocarpine that do not evoke overt seizures affect long-term spatial memory but not learning in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Subc | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy.
Topics: Animals; Cell Separation; Dentate Gyrus; Electric Conductivity; Epilepsy, Temporal Lobe; Gene Expres | 1998 |
Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Ionto | 1998 |
Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat.
Topics: Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Radiation; | 1999 |
Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats.
Topics: Animals; Dentate Gyrus; Epilepsies, Partial; GAP-43 Protein; Immunohistochemistry; Male; Phosphoprot | 1999 |
Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Cell Size; Epilepsy; Excitatory Posts | 1999 |
Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Diazepam; Dopamine; Electroencephalography; Extracellu | 1999 |
p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure.
Topics: Animals; Apoptosis; Entorhinal Cortex; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; | 1999 |
Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain.
Topics: Amygdala; Animals; Base Sequence; Brain; Corpus Striatum; Dentate Gyrus; Frontal Lobe; Gene Expressi | 1999 |
Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes.
Topics: Animals; Brain; Cell Nucleus; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; DNA-Binding Proteins | 1999 |
Differential regulation of cytokine expression following pilocarpine-induced seizure.
Topics: Animals; Cell Death; Ciliary Neurotrophic Factor; Cytokines; Gene Expression Regulation; Gliosis; Gr | 1999 |
Ventricular enlargement and the lithium/pilocarpine seizure model: possible explanation for agonistic behaviour.
Topics: Acepromazine; Agonistic Behavior; Animals; Anticonvulsants; Ketamine; Lateral Ventricles; Lithium; M | 2000 |
Infiltration of lymphocytes in the limbic brain following stimulation of subclinical cellular immunity and low dosages of lithium and a cholinergic agent.
Topics: Animals; Cholinergic Agents; Female; Immunity, Cellular; Limbic System; Lithium; Lymphocytes; Male; | 1999 |
Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting.
Topics: Animals; Cycloheximide; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Protein S | 1999 |
Facilitation of seizures in limbic epileptic rats by complex 1 microTesla magnetic fields.
Topics: Animals; Disease Models, Animal; Electromagnetic Fields; Limbic System; Lithium Chloride; Male; Pilo | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
Nitrone spin trapping compound N-tert-butyl-alpha-phenylnitrone prevents seizures induced by anticholinesterases.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Behavior, Animal; Brain; Cholinesterase Inhibitors; | 1999 |
L-type Ca(2+) channel blocker inhibits mossy fiber sprouting and cognitive deficits following pilocarpine seizures in immature mice.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cogn | 2000 |
Ultrastructural identification of dentate granule cell death from pilocarpine-induced seizures.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Human | 2000 |
Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy.
Topics: Animals; Electroshock; Epilepsy, Temporal Lobe; Genes, fos; Hippocampus; Long-Term Potentiation; Mal | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Car | 2000 |
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Inhibitors | 2000 |
Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electrophysio | 2000 |
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Down-Regulation; Electrophysiology; Electroshock; Immunoh | 2000 |
The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Electroshock; Kindling, Neurologi | 2000 |
Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat.
Topics: Animals; Brain; Cell Survival; Lithium; Male; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, | 2000 |
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2000 |
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glutamic Acid; Male; P | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyru | 2001 |
Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Disease Models, Animal; Disease Progression; | 2001 |
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Electroencephalography; Electrophysiology; gamma-Ami | 2001 |
Diurnal variation in pilocarpine-induced generalized tonic-clonic seizure activity.
Topics: Animals; Circadian Rhythm; Male; Muscarinic Agonists; Photoperiod; Pilocarpine; Rats; Rats, Wistar; | 2001 |
Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine.
Topics: Aminoquinolines; Animals; Fluorescent Dyes; Male; Muscarinic Agonists; Nerve Degeneration; Neurons; | 2001 |
Alteration of cardiovascular and neuronal function in M1 knockout mice.
Topics: Animals; Calcium Channels; Cells, Cultured; Electrophysiology; Gene Targeting; GTP-Binding Proteins; | 2001 |
Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells.
Topics: Action Potentials; Animals; Biotin; Cell Size; Cell Survival; Cortical Synchronization; Dendrites; E | 2001 |
A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus.
Topics: Animals; Brain; Calcineurin; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Hippocamp | 2001 |
Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity.
Topics: Action Potentials; Animals; Axons; Dendrites; Dentate Gyrus; Disease Models, Animal; Electric Stimul | 2001 |
Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebrovascular Circulation; Drug Synergi | 2002 |
Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Topics: Aging; Aminophylline; Animals; Cell Differentiation; Cognition Disorders; Growth Cones; Hippocampus; | 2002 |
Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; | 2002 |
Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus.
Topics: Animals; Calbindins; Cell Count; Dentate Gyrus; Male; Neurons; Neuropeptide Y; Parvalbumins; Pilocar | 2002 |
Attenuating effects of melatonin on pilocarpine-induced seizures in rats.
Topics: Age Factors; Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; Melatonin; N-Methylscopolami | 2002 |
Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline.
Topics: Acetylcholinesterase; Animals; Anxiety; Avoidance Learning; Hippocampus; Learning Disabilities; Male | 2002 |
Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice.
Topics: Animals; Cell Death; Convulsants; Dentate Gyrus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strain | 2002 |
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electrosho | 2002 |
Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study.
Topics: Animals; Antimetabolites; Autoradiography; Brain; Deoxyglucose; Disease Models, Animal; Energy Metab | 2002 |
The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures.
Topics: Aminoacetonitrile; Animals; Blotting, Western; Cell Death; Disease Models, Animal; Enzyme Activation | 2002 |
The interaction between pilocarpine and hexobarbital in male rats.
Topics: Anesthesia; Animals; Drug Interactions; Drug Tolerance; Hexobarbital; Male; Pilocarpine; Rats; Seizu | 1976 |
Mediation of myoclonic seizures by dopamine and clonic seizures by acetylcholine and GABA.
Topics: Animals; Apomorphine; Bicuculline; Dose-Response Relationship, Drug; Flurothyl; Haloperidol; Isoquin | 1977 |
Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures.
Topics: Animals; Brain Mapping; Cerebral Cortex; Chlorides; Cyclic AMP; Cyclic GMP; Dose-Response Relationsh | 1992 |
Progressive accumulation of large aggregates of calcium-containing polysaccharides and basophilic debris within specific thalamic nuclei after lithium/pilocarpine-induced seizures.
Topics: Animals; Basophils; Calcium; Histocytochemistry; Lithium; Male; Pilocarpine; Polysaccharides; Rats; | 1992 |
Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus.
Topics: Animals; Corpus Callosum; Electroencephalography; Hippocampus; Histocytochemistry; Lithium; Pilocarp | 1992 |
Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Drug Interactions | 1992 |
Characterization of cholinergic regulation of seizures by the midline thalamus.
Topics: Animals; Female; Neostigmine; Nicotine; Parasympathomimetics; Pentylenetetrazole; Pilocarpine; Rats; | 1992 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microi | 1991 |
[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
Topics: Acetylcholine; Animals; Cerebral Cortex; Chlorides; Choline; Hemicholinium 3; Hippocampus; Kinetics; | 1991 |
Anticonvulsant effect of striatal dopamine D2 receptor stimulation: dependence on cortical circuits?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Corpus Striatum; Dopamine Agents; Ergolines; Female; Kain | 1991 |
Dopamine D1 and D2 receptors mediate opposite functions in seizures induced by lithium-pilocarpine.
Topics: Animals; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Electroencephalograph | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lit | 1991 |
Radial maze learning deficits and mediodorsal thalamic damage in context of multifocal seizure-induced brain lesions.
Topics: Analysis of Variance; Animals; Brain; Humans; Infant; Learning; Lithium; Memory; Necrosis; Pilocarpi | 1991 |
D-2 agonists protect rodents against pilocarpine-induced convulsions by stimulating D-2 receptors in the striatum, but not in the substantia nigra.
Topics: Animals; Corpus Striatum; Ergolines; Female; Male; Mice; Microinjections; Pilocarpine; Quinpirole; R | 1991 |
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Convulsants; Dose-Response Relationship, Drug; Dr | 1991 |
Seizure promotion and protection by D-1 and D-2 dopaminergic drugs in the mouse.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Dose-Response R | 1990 |
Anticonvulsant action of SCH 23390 in the striatum of the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Antiparkinson | 1990 |
Paradoxical anticonvulsant activity of the gamma-aminobutyrate antagonist bicuculline methiodide in the rat striatum.
Topics: Animals; Anticonvulsants; Bicuculline; Corpus Striatum; Electroencephalography; GABA Antagonists; Ma | 1991 |
Transient occlusion of rat carotid arteries decreases susceptibility to pilocarpine seizures.
Topics: Animals; Behavior, Animal; Carotid Arteries; Cerebrovascular Circulation; Constriction; Disease Susc | 1991 |
Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus.
Topics: Animals; Atropine; Clonidine; Electric Stimulation; Epilepsy; Hippocampus; Male; Parasympathomimetic | 1991 |
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; N | 1990 |
Dopamine control of seizure propagation: intranigral dopamine D1 agonist SKF-38393 enhances susceptibility to seizures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine; Dose | 1990 |
Dopamine D1 receptor modulation of pilocarpine-induced convulsions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dose-Response Relationship, Dru | 1990 |
Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats.
Topics: Animals; Brain; Brain Edema; Chlorides; Isoflurophate; Lithium; Lithium Chloride; Male; Organ Specif | 1990 |
Substantia nigra regulates action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethosuximide; Ma | 1990 |
Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroenc | 1990 |
D-1 dopamine agonist administration reduces the threshold for convulsions produced by pilocarpine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Convulsants; Dopa | 1989 |
Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Injections; Limbic System; Male; | 1988 |
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Oxadi | 1988 |
Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine.
Topics: Animals; Anticonvulsants; Brain Mapping; Chlorides; Dose-Response Relationship, Drug; Drug Synergism | 1988 |
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol | 1988 |
2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Male; Muscimol; N | 1986 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalog | 1986 |
Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Cerebellum; Limbic System; Male; M | 1987 |
Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats.
Topics: Animals; Aspartic Acid; Corpus Striatum; Globus Pallidus; Kainic Acid; Male; N-Methylaspartate; Pilo | 1988 |
The threshold for limbic seizures in rats is decreased by intranigral morphine.
Topics: Animals; Convulsants; Electroencephalography; Limbic System; Male; Morphine; Pilocarpine; Rats; Rats | 1986 |
Dopamine-sensitive anticonvulsant site in the rat striatum.
Topics: Amino Acids; Animals; Anticonvulsants; Apomorphine; Corpus Striatum; Dopamine; Haloperidol; Male; Ne | 1988 |
Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats.
Topics: Animals; Electroshock; Globus Pallidus; Male; Microinjections; Muscimol; Pilocarpine; Rats; Rats, In | 1988 |
Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Male; Mefenamic Acid; Phenylbutazone; Piloc | 1988 |
Conditioned taste aversion is reduced in rats with a history of lithium/pilocarpine-induced limbic seizures.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Limbic System; Lithium; Male; Pilocarpine; Rat | 1988 |
The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, | 1987 |
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
Topics: Aging; Animals; Behavior, Animal; Brain; Disease Susceptibility; Electroencephalography; Female; Mal | 1987 |
Nonmuscarinic neurotoxicity of oxotremorine.
Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose | 1987 |
Only certain antiepileptic drugs prevent seizures induced by pilocarpine.
Topics: Animals; Anticonvulsants; Brain; Electroencephalography; Male; Pilocarpine; Rats; Rats, Inbred Strai | 1987 |
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Topics: Aminocaproates; Animals; Isoniazid; Male; Microinjections; Pilocarpine; Rats; Rats, Inbred Strains; | 1986 |
Status epilepticus facilitated by pilocarpine in amygdala-kindled rats.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pilocarpine; Rats; Ra | 1986 |
Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Limbic System; Male; Pilocarpine | 1986 |
Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.
Topics: Animals; Behavior, Animal; Hippocampus; Injections, Intraperitoneal; Limbic System; Male; Motor Neur | 1986 |
Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Electroencephalography; Glutamate Decarboxylase; Male; N | 1986 |
Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates.
Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Animals; Benzodiazepinones; Bicuculline; Brain; Carboli | 1985 |
Effects of morphine and naloxone on pilocarpine-induced convulsions in rats.
Topics: Animals; Drug Interactions; Endorphins; Limbic System; Male; Morphine; Naloxone; Pilocarpine; Rats; | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Pharmacological evidence for cholinergic processes in various central synapses.
Topics: Animals; Cats; Electrophysiology; Heterocyclic Compounds; Muscle Spindles; Neuromuscular Junction; P | 1966 |
Evidence for the release and depletion of the postsynaptic inhibitory transmitter by pilocarpine.
Topics: Animals; Injections, Intravenous; Mice; Pilocarpine; Seizures; Stimulation, Chemical; Strychnine; Sy | 1968 |
Tremorigenic and convulsant actions of intracerebrally administered vegetative poisons in the mouse.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Carbachol; Central Nervous System Stimulants; Hist | 1967 |
Different central effects of the 5-HT antagonists mianserine and cyproheptadine.
Topics: Animals; Behavior, Animal; Cyproheptadine; Dibenzazepines; Drug Antagonism; Electroshock; Lethal Dos | 1972 |
Relationship between age, electroshock seizure susceptibility, and cerebral gamma-aminobutyric acid level.
Topics: Age Factors; Aminobutyrates; Animals; Body Weight; Brain Chemistry; Cerebellum; Cerebral Cortex; Ele | 1968 |
[vidence for a muscarinic inhibitory mechanism in the cerebral cortex].
Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Cortex; Drug Antagonism; Electric Stimulation; Elec | 1969 |