pilocarpine has been researched along with Sclerosis in 12 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the main features of mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) in humans, we examined the expression of CB1R in hippocampal astrocytes of epileptic rats." | 3.80 | Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi. ( Jiang, W; Kang, JJ; Li, J; Liu, YY; Ma, L; Meng, XD; Ou-Yang, TP; Wei, D; Wu, C; Yang, F; Zhu, GM, 2014) |
| "Epilepsy is a frequent neurological disorder that affects directly 0." | 1.42 | The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus. ( Orbán-Kis, K; Szabadi, T; Szilágyi, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mátyás, A | 1 |
| Borbély, E | 1 |
| Mihály, A | 1 |
| Gelfuso, EA | 1 |
| Reis, SL | 1 |
| Pereira, AMS | 1 |
| Aguiar, DSR | 1 |
| Beleboni, RO | 1 |
| Wu, H | 1 |
| Liu, Y | 1 |
| Liu, L | 1 |
| Meng, Q | 1 |
| Du, C | 1 |
| Li, K | 1 |
| Dong, S | 1 |
| Zhang, Y | 1 |
| Li, H | 1 |
| Zhang, H | 1 |
| Pitsch, J | 1 |
| Becker, AJ | 1 |
| Schoch, S | 1 |
| Müller, JA | 1 |
| de Curtis, M | 1 |
| Gnatkovsky, V | 1 |
| Kharatishvili, I | 1 |
| Shan, ZY | 1 |
| She, DT | 1 |
| Foong, S | 1 |
| Kurniawan, ND | 1 |
| Reutens, DC | 1 |
| Simões, PSR | 1 |
| Visniauskas, B | 1 |
| Perosa, SR | 1 |
| Yacubian, EMT | 1 |
| Centeno, R | 1 |
| Canzian, M | 1 |
| Lopes-Cendes, I | 1 |
| Maurer Morelli, CV | 1 |
| Carrete, H | 1 |
| Cavalheiro, EA | 1 |
| Tufik, S | 1 |
| Chagas, JR | 1 |
| Naffah Mazzacoratti, MDG | 1 |
| Meng, XD | 1 |
| Wei, D | 1 |
| Li, J | 1 |
| Kang, JJ | 1 |
| Wu, C | 1 |
| Ma, L | 1 |
| Yang, F | 1 |
| Zhu, GM | 1 |
| Ou-Yang, TP | 1 |
| Liu, YY | 1 |
| Jiang, W | 1 |
| Orbán-Kis, K | 1 |
| Szabadi, T | 1 |
| Szilágyi, T | 1 |
| Long, L | 1 |
| Xiao, B | 1 |
| Feng, L | 1 |
| Yi, F | 1 |
| Li, G | 1 |
| Li, S | 1 |
| Mutasem, MA | 1 |
| Chen, S | 1 |
| Bi, F | 1 |
| Li, Y | 1 |
| Kann, O | 1 |
| Kovács, R | 2 |
| Njunting, M | 1 |
| Behrens, CJ | 1 |
| Otáhal, J | 1 |
| Lehmann, TN | 2 |
| Gabriel, S | 2 |
| Heinemann, U | 2 |
| Shetty, AK | 1 |
| Hattiangady, B | 1 |
| Jauch, R | 1 |
| Schulze, K | 1 |
| Kivi, A | 1 |
| Eilers, A | 1 |
1 review available for pilocarpine and Sclerosis
| Article | Year |
|---|---|
Concise review: prospects of stem cell therapy for temporal lobe epilepsy.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Cell Differentiation; Disease Models, Animal; | 2007 |
11 other studies available for pilocarpine and Sclerosis
| Article | Year |
|---|---|
Hippocampal Sclerosis in Pilocarpine Epilepsy: Survival of Peptide-Containing Neurons and Learning and Memory Disturbances in the Adult NMRI Strain Mouse.
Topics: Aging; Animals; Calbindin 2; Cell Proliferation; Cell Survival; Densitometry; Epilepsy; Hippocampus; | 2021 |
Neuroprotective effects and improvement of learning and memory elicited by erythravine and 11α-hydroxy-erythravine against the pilocarpine model of epilepsy.
Topics: Alkaloids; Animals; Convulsants; Epilepsy; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Imm | 2020 |
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Topics: Animals; ARNTL Transcription Factors; Biological Clocks; Circadian Rhythm; Epilepsy, Temporal Lobe; | 2021 |
Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Circadian Rhythm; Cluster Analysis; Disease Models, Animal; Electroencepha | 2017 |
MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Mapping; Calcium-Binding Proteins; Complement C3; Diffusion Magnetic Resonance | 2014 |
Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE).
Topics: Adult; Animals; Anterior Temporal Lobectomy; Disease Models, Animal; Epilepsy, Temporal Lobe; Female | 2014 |
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Topics: Adult; Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Fl | 2014 |
The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus.
Topics: Animals; Axons; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Neurons; Neurope | 2015 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans.
Topics: Adult; Animals; Chronic Disease; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Fluorescent | 2005 |
Alterations of glial cell function in temporal lobe epilepsy.
Topics: Animals; Barium; Epilepsy, Temporal Lobe; Extracellular Space; Hippocampus; Humans; In Vitro Techniq | 2000 |