Compounds > pilocarpine
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pilocarpine and Salivary Gland Diseases

pilocarpine has been researched along with Salivary Gland Diseases in 19 studies

Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.

Salivary Gland Diseases: Diseases involving the SALIVARY GLANDS.

Research Excerpts

ExcerptRelevanceReference
" pilocarpine for at least for 12 weeks unless they had experienced unacceptable adverse effects."5.35Oral pilocarpine (5mg t.i.d.) used for xerostomia causes adverse effects in Japanese. ( Asakage, T; Ebihara, Y; Igaki, H; Nakagawa, K; Nakamura, N; Nakao, K; Ohtomo, K; Sasano, N; Shiraishi, K; Terahara, A; Yamashita, H, 2009)
"Patients with head and neck cancers can develop salivary hypofunction after radiotherapy."2.70Salivary scintigraphy for assessing the protective effect of pilocarpine in head and neck irradiated tumours. ( Ferre, J; Fuster, D; Lomeña, F; Martin, F; Mateos, JJ; Navalpotro, B; Ortega, M; Pavia, J; Pons, F; Rovirosa, A; Setoain, X, 2001)
" pilocarpine for at least for 12 weeks unless they had experienced unacceptable adverse effects."1.35Oral pilocarpine (5mg t.i.d.) used for xerostomia causes adverse effects in Japanese. ( Asakage, T; Ebihara, Y; Igaki, H; Nakagawa, K; Nakamura, N; Nakao, K; Ohtomo, K; Sasano, N; Shiraishi, K; Terahara, A; Yamashita, H, 2009)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199010 (52.63)18.7374
1990's2 (10.53)18.2507
2000's6 (31.58)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Riley, P1
Glenny, AM1
Hua, F1
Worthington, HV1
Nakamura, N1
Sasano, N1
Yamashita, H1
Igaki, H1
Shiraishi, K1
Terahara, A1
Asakage, T1
Nakao, K1
Ebihara, Y1
Ohtomo, K1
Nakagawa, K1
Gallego, L1
Junquera, L1
Cuesta, P1
Rosado, P1
Brennan, MT1
Shariff, G1
Lockhart, PB1
Fox, PC4
RAYNAUD, J1
BLANC, G1
SEIFERT, G2
POSTLER, G1
Mignogna, MD1
Fedele, S1
Lo Russo, L1
Ferguson, MM1
Mateos, JJ1
Setoain, X1
Ferre, J1
Rovirosa, A1
Navalpotro, B1
Martin, F1
Ortega, M1
Lomeña, F1
Fuster, D1
Pavia, J1
Pons, F1
O'Connell, AC1
Eichner, H1
van der Ven, PF1
Baum, BJ1
Mandel, ID1
Szabó, G2
Donath, K1
Spillner, M1
Hug, I1
Ancri, D1
Laudenbach, P1
Tarkiainen, E1
Stjernvall, L1
Tarkkanen, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray on the Relief of Dry Mouth Symptoms[NCT04186806]40 participants (Actual)Interventional2019-11-02Completed
Multicenter, Controlled Parallel Groups Trial to Evaluate the Efficacy, Safety and Acceptability of OGT Oromucosal Spray Versus a Saliva Substitute in the Treatment of Xerostomia in Geriatrics[NCT00350350]74 participants (Actual)Observational2003-10-31Completed
Multicenter Controlled Parallel-Groups Trial to Evaluate the Efficacy, Safety and Acceptability of TGO Buccal Spray Versus a Saliva Substitute in the Treatment of Psychotropic Medicines-Induced Xerostomia[NCT00332618]74 participants Observational2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

10 cm Mean Mouth Dryness Visual Analog Scale

Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 120 minutes

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray4.86
Biotene Moisturizing Mouth Spray5.41

10 cm Mean Mouth Dryness Visual Analog Scale

Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 30 minutes

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray4.51
Biotene Moisturizing Mouth Spray4.75

10 cm Mean Mouth Dryness Visual Analog Scale

Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 60 minutes

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray4.58
Biotene Moisturizing Mouth Spray5.04

10 cm Mean Mouth Dryness Visual Analog Score

Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 240 minutes post dose

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray5.14
Biotene Moisturizing Mouth Spray5.68

10 cm Mean Mouth Dryness Visual Analog Score

Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 5 minutes

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray4.54
Biotene Moisturizing Mouth Spray4.62

10 cm Mouth Dryness Visual Analog Scale

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 15 minutes

Interventioncm (Least Squares Mean)
3M(TM) Dry Mouth Moisturizing Spray-2.394
Biotene Moisturizing Mouth Spray-2.036

10 cm Mouth Dryness Visual Analog Scale

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 30 minutes

Interventioncm (Least Squares Mean)
3M(TM) Dry Mouth Moisturizing Spray-2.420
Biotene Moisturizing Mouth Spray-1.900

10 cm Mouth Dryness Visual Analog Scale

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 5 minutes

Interventioncm (Least Squares Mean)
3M(TM) Dry Mouth Moisturizing Spray-2.203
Biotene Moisturizing Mouth Spray-1.871

10 cm Mouth Dryness Visual Analog Score

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 120 minutes

Interventioncm (Least Squares Mean)
3M(TM) Dry Mouth Moisturizing Spray-2.364
Biotene Moisturizing Mouth Spray-1.657

10 cm Mouth Dryness Visual Analog Score

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 240 minutes

Interventioncm (Least Squares Mean)
3M Dry Mouth Moisturizing Spray-2.322
Biotene Moisturizing Mouth Spray-1.665

10 cm Mouth Dryness Visual Analog Score

Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 60 minutes

Interventioncm (Least Squares Mean)
3M(TM) Dry Mouth Moisturizing Spray-2.455
Biotene Moisturizing Mouth Spray-1.833

10 cm Mouth Dryness Visual Analog Score

Primary endpoint will be paired-difference in Visual Analog Scale (VAS) between experimental and active control product. On the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms. (NCT04186806)
Timeframe: 15 minutes post dose

Interventioncm (Mean)
3M(TM) Dry Mouth Moisturizing Spray4.51
Biotene Moisturizing Mouth Spray4.6

Reviews

5 reviews available for pilocarpine and Salivary Gland Diseases

ArticleYear
Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
    The Cochrane database of systematic reviews, 2017, 07-31, Volume: 7

    Topics: Amifostine; Drugs, Chinese Herbal; Female; Fibroblast Growth Factor 7; Humans; Male; Pilocarpine; Qu

2017
Treatment of xerostomia: a systematic review of therapeutic trials.
    Dental clinics of North America, 2002, Volume: 46, Issue:4

    Topics: Acupuncture Therapy; Bias; Humans; Muscarinic Agonists; Pilocarpine; Radiotherapy; Randomized Contro

2002
Pilocarpine and other cholinergic drugs in the management of salivary gland dysfunction.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 75, Issue:2

    Topics: Anethole Trithione; Bethanechol; Bethanechol Compounds; Humans; Parasympathomimetics; Pilocarpine; P

1993
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Management of dry mouth.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym

1997
Natural history and prevention of radiation injury.
    Advances in dental research, 2000, Volume: 14

    Topics: Animals; Disease Models, Animal; Disease Progression; Free Radical Scavengers; Humans; Muscarinic Ag

2000

Trials

2 trials available for pilocarpine and Salivary Gland Diseases

ArticleYear
Salivary scintigraphy for assessing the protective effect of pilocarpine in head and neck irradiated tumours.
    Nuclear medicine communications, 2001, Volume: 22, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Mi

2001
Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunction.
    Oral surgery, oral medicine, and oral pathology, 1986, Volume: 61, Issue:3

    Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Middle Aged; Pilocarpine; Place

1986

Other Studies

12 other studies available for pilocarpine and Salivary Gland Diseases

ArticleYear
Oral pilocarpine (5mg t.i.d.) used for xerostomia causes adverse effects in Japanese.
    Auris, nasus, larynx, 2009, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Body Weight; Carcinoma; Dose-Response Relationship, Drug; Drug Admin

2009
Symptomatic unilateral submandibular gland aplasia.
    The British journal of oral & maxillofacial surgery, 2009, Volume: 47, Issue:3

    Topics: Adult; Cholinergic Agents; Female; Humans; Pilocarpine; Saliva, Artificial; Salivary Gland Diseases;

2009
[ACTION OF CORTISONE AND PILOCARPINE ON THE DEVELOPMENT OF THE SALIVARY VIRUS IN THE FIELD-MOUSE (APODEMUS SYLVATICUS), THE GERBIL (MERIONES SHAWI) AND THE JERBOA (DIPODILLUS CAMPESTRIS)].
    Annales de l'Institut Pasteur, 1964, Volume: 107

    Topics: Adrenal Glands; Animals; Arvicolinae; Cortisone; Gerbillinae; Lung; Murinae; Necrosis; Pathology; Ph

1964
[ON THE EFFECT OF SUBSTANCES WITH NEUROVEGETATIVE ACTION ON THE SALIVARY GLANDS AND ON EXPERIMENTAL SIALADENOSIS].
    Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1964, Volume: 130

    Topics: Atropine; Autonomic Agents; Guanethidine; Norepinephrine; Pharmacology; Pilocarpine; Pyrogallol; Rat

1964
Anorexia/bulimia-related sialadenosis of palatal minor salivary glands.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2004, Volume: 33, Issue:7

    Topics: Adult; Anorexia Nervosa; Bulimia; Female; Humans; Muscarinic Agonists; Palate, Hard; Parotid Disease

2004
[Salivary gland diseases. Clinical aspects, diagnosis, therapy. Part 4. Therapy (congenital malformations, inflammatory salivary gland diseases, sialadenitis, sialolithiasis, therapy--recommendations for oral hygiene care, saliva-stimulating drugs)].
    Fortschritte der Medizin, 1978, Oct-05, Volume: 96, Issue:37

    Topics: Humans; Mouthwashes; Parotitis; Pilocarpine; Salivary Duct Calculi; Salivary Gland Diseases; Salivar

1978
Systemic therapy of salivary gland hypofunction.
    Journal of dental research, 1987, Volume: 66 Spec No

    Topics: Anethole Trithione; Bromhexine; Humans; Pilocarpine; Salivary Gland Diseases; Salivary Glands; Xeros

1987
[Treatment of xerostomia with pilocarpine. Based on l5 years' experience and treatment of 500 patients].
    Fogorvosi szemle, 1985, Volume: 78, Issue:3

    Topics: Humans; Pilocarpine; Salivary Gland Diseases; Sjogren's Syndrome; Xerostomia

1985
The influence of the autonomic nervous system on the ultrastructure of the parotid acinar cells. Experimental contribution to the neurohormonal sialadenosis.
    Virchows Archiv. A, Pathological anatomy and histology, 1974, Volume: 364, Issue:1

    Topics: Animals; Autonomic Nervous System; Axons; Cell Membrane; Cell Nucleolus; Endoplasmic Reticulum; Fema

1974
[Isotopes in the functional diagnosis of the parotid. I. Function of the normal parotid (author's transl)].
    Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1973, Volume: 119, Issue:2

    Topics: Chlorates; Humans; Parasympatholytics; Parasympathomimetics; Parotid Gland; Pilocarpine; Radionuclid

1973
[A new radionucleid test on salivary gland function].
    Deutsche Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt fur die gesamte Zahn-, Mund-, und Kieferheilkunde, 1973, Volume: 60, Issue:5

    Topics: Atropine; Humans; Parotid Gland; Pilocarpine; Radionuclide Imaging; Salivary Gland Diseases; Salivar

1973
Pilocarpine as a diagnostic aid in the scintillography of sialopathies.
    Acta oto-laryngologica, 1970, Volume: 70, Issue:2

    Topics: Adult; Aged; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Parotid Gland; Pilocarpine; Ra

1970