pilocarpine has been researched along with Parkinsonian Disorders in 6 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 7.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 5.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| " Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic." | 3.81 | Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Morató, X; Stagljar, I, 2015) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 3.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 1.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, K | 1 |
| Abe, H | 1 |
| Koganemaru, G | 1 |
| Ikeda, T | 1 |
| Arimori, K | 1 |
| Ishida, Y | 1 |
| Gandía, J | 1 |
| Morató, X | 1 |
| Stagljar, I | 1 |
| Fernández-Dueñas, V | 1 |
| Ciruela, F | 1 |
| Podurgiel, S | 1 |
| Collins-Praino, LE | 1 |
| Yohn, S | 1 |
| Randall, PA | 1 |
| Roach, A | 1 |
| Lobianco, C | 1 |
| Salamone, JD | 3 |
| FEINBERG, I | 1 |
| KORESKO, RL | 1 |
| HELLER, N | 1 |
| STEINBERG, HR | 1 |
| Betz, AJ | 1 |
| McLaughlin, PJ | 1 |
| Burgos, M | 1 |
| Weber, SM | 1 |
| Correa, M | 1 |
| Carlson, BB | 1 |
| Wisniecki, A | 1 |
| Mayorga, AJ | 1 |
| Nisenbaum, E | 1 |
| Nisenbaum, L | 1 |
| Felder, C | 1 |
1 review available for pilocarpine and Parkinsonian Disorders
| Article | Year |
|---|---|
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism.
Topics: Acetylcholine; Animals; Humans; Jaw; Mice; Mice, Knockout; Motor Activity; Muscarinic Agonists; Musc | 2001 |
5 other studies available for pilocarpine and Parkinsonian Disorders
| Article | Year |
|---|---|
Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benzothiazoles; Disease Models, Animal; Infusions, Intra | 2015 |
Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
Topics: Adenosine A2 Receptor Antagonists; Animals; Jaw; Male; Mice, Inbred C57BL; Mice, Knockout; Movement; | 2015 |
Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Dopamine Agonists; Locomotion; Male; Muscarini | 2013 |
UNUSUALLY HIGH DREAM TIME IN A HALLUCINATING PATIENT.
Topics: Dreams; Drug Therapy; Electroencephalography; Eye Movements; Geriatrics; Hallucinations; Humans; Par | 1965 |
The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.
Topics: Animals; Atropine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; J | 2007 |