pilocarpine has been researched along with Parkinson Disease in 8 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ju, UH | 1 |
| Liu, FC | 1 |
| Lin, CS | 1 |
| Huang, WY | 1 |
| Lin, TY | 1 |
| Shen, CH | 1 |
| Chou, YC | 1 |
| Lin, CL | 1 |
| Lin, KT | 1 |
| Kao, CH | 1 |
| Chen, CH | 1 |
| Yang, TY | 1 |
| Yamashita, F | 2 |
| Hirayama, M | 2 |
| Nakamura, T | 2 |
| Takamori, M | 2 |
| Hori, N | 2 |
| Uchida, K | 1 |
| Hama, T | 1 |
| Sobue, G | 2 |
| Salamone, JD | 2 |
| Collins-Praino, LE | 1 |
| Pardo, M | 1 |
| Podurgiel, SJ | 1 |
| Baqi, Y | 1 |
| Müller, CE | 1 |
| Schwarzschild, MA | 1 |
| Correa, M | 2 |
| Ishiwari, K | 1 |
| Mingote, S | 1 |
| Trevitt, JT | 1 |
| Carlson, BB | 1 |
| Simola, N | 1 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Morelli, M | 1 |
| Watanabe, H | 1 |
| Ito, H | 1 |
| Mabuchi, N | 1 |
| Kent, S | 1 |
| Hughes, BO | 1 |
| Spicer, B | 1 |
8 other studies available for pilocarpine and Parkinson Disease
| Article | Year |
|---|---|
Risk of Parkinson disease in Sjögren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Comorbidity; Female; Humans; Hydroxychl | 2019 |
Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests.
Topics: 3-Iodobenzylguanidine; Aged; Autonomic Nervous System; Autonomic Nervous System Diseases; Blood Pres | 2010 |
Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Disease Models, Animal; Jaw; Male; | 2013 |
The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response R | 2004 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Pupillary supersensitivity and visual disturbance in Parkinson's disease.
Topics: Age Factors; Epinephrine; Female; Humans; Light; Male; Middle Aged; Miotics; Mydriatics; Parkinson D | 2008 |
Continuous drug delivery methods reflect progress in therapy for chronic diseases.
Topics: Aged; Chronic Disease; Cytarabine; Dosage Forms; Drug Implants; Glaucoma; Humans; Injections, Intrav | 1977 |
Some anticholinergic activities of BRL 1288--a new anti-Parkinson drug.
Topics: Animals; Disease Models, Animal; Glycolates; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle, | 1969 |