pilocarpine has been researched along with Neuroblastoma in 12 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on the pilocarpine hydrochloride-induced rat model of epilepsy, cortical-striatum brain slices of rats were examined based on field excitatory post-synaptic potentials." | 8.12 | Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression ( Tan, ZG; Wen, F; Xiang, J, 2022) |
| "Based on the pilocarpine hydrochloride-induced rat model of epilepsy, cortical-striatum brain slices of rats were examined based on field excitatory post-synaptic potentials." | 4.12 | Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression ( Tan, ZG; Wen, F; Xiang, J, 2022) |
| " Finally, we investigated its effects on pilocarpine-induced seizures in rats." | 3.78 | Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. ( Chow, JC; Huang, CW; Tsai, JJ; Wu, SN, 2012) |
| " Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner." | 3.77 | Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. ( Cao, Q; Edelstein, J; Hao, T; Morales, L; Rockwell, P, 2011) |
| " In the present study, we investigated various commercial antiglaucoma drugs including timolol (0." | 3.72 | Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. ( Fong, JC; Hong, SJ; Wang, HZ; Wu, KY, 2003) |
| "Guinea pigs infected with parainfluenza virus were hyperreactive to electrical stimulation of the vagus nerves, but not to intravenous acetylcholine, indicating that hyperreactivity was due to increased release of acetylcholine from parasympathetic nerves." | 1.35 | Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. ( Fryer, AD; Jacoby, DB; Moreno-Vinasco, L; Verbout, NG, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, F | 1 |
| Tan, ZG | 1 |
| Xiang, J | 1 |
| Moreno-Vinasco, L | 1 |
| Verbout, NG | 1 |
| Fryer, AD | 1 |
| Jacoby, DB | 1 |
| Edelstein, J | 1 |
| Hao, T | 1 |
| Cao, Q | 1 |
| Morales, L | 1 |
| Rockwell, P | 1 |
| Huang, CW | 1 |
| Chow, JC | 1 |
| Tsai, JJ | 1 |
| Wu, SN | 1 |
| Hong, SJ | 1 |
| Wu, KY | 1 |
| Wang, HZ | 1 |
| Fong, JC | 1 |
| Teber, I | 1 |
| Köhling, R | 1 |
| Speckmann, EJ | 1 |
| Barnekow, A | 1 |
| Kremerskothen, J | 1 |
| Milligan, G | 1 |
| Strange, PG | 2 |
| Shifrin, GS | 1 |
| Klein, WL | 1 |
| Szekeres, PG | 1 |
| Koenig, JA | 1 |
| Edwardson, JM | 1 |
| Birdsall, NJ | 1 |
| Burgen, AS | 1 |
| Gullis, RJ | 1 |
| Traber, J | 1 |
| Fischer, K | 1 |
| Buchen, C | 1 |
| Hamprecht, B | 1 |
| Simantov, R | 1 |
| Sachs, L | 1 |
12 other studies available for pilocarpine and Neuroblastoma
| Article | Year |
|---|---|
Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression
Topics: Animals; Epilepsy; Humans; NAV1.2 Voltage-Gated Sodium Channel; Neuroblastoma; NF-E2-Related Factor | 2022 |
Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Bronchial Hyperreactivity; Bronchoconstriction; Cell | 2009 |
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.
Topics: Apoptosis; Carbachol; Cell Line, Tumor; Culture Media, Serum-Free; Humans; Neuroblastoma; Neurons; O | 2011 |
Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cell Line, Tumor; Delayed Rectifier Potassium | 2012 |
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.
Topics: Animals; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Calcium; Carteolol; Cell Death; D | 2003 |
Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC).
Topics: Animals; Blotting, Northern; Brain; Cell Line, Tumor; Cholinergic Agents; Cysteine-Rich Protein 61; | 2004 |
Apparent down-regulation of muscarinic acetylcholine receptors of neuroblastoma cells by pilocarpine is due to occluded agonist.
Topics: Humans; Neuroblastoma; Pilocarpine; Receptors, Muscarinic; Scopolamine | 1983 |
Regulation of muscarinic acetylcholine receptor concentration in cloned neuroblastoma cells.
Topics: Acetylcholine; Animals; Arecoline; Carbachol; Cell Line; Clone Cells; Dose-Response Relationship, Dr | 1980 |
The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line.
Topics: Arecoline; Bethanechol; Carbachol; Endocytosis; Humans; Kinetics; Ligands; Methacholine Chloride; Mu | 1998 |
Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells.
Topics: Acetylcholine; Atropine; Carbachol; Cell Line; Cell Membrane; Enzyme Activation; Guanylate Cyclase; | 1977 |
Effects of cholinergic agents and sodium ions on the levels of guanosine and adenosine 3':5'-cyclic monophosphates in neuroblastoma and neuroblastoma X glioma hybrid cells.
Topics: Acetylcholine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interaction | 1975 |
Regulation of acetylcholine receptors in relation to acetylcholinesterase in neuroblastoma cells.
Topics: Acetylcholinesterase; Animals; Atropine; Carbachol; Cell Differentiation; Cell Division; Clone Cells | 1973 |