pilocarpine has been researched along with Nerve Degeneration in 105 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice." | 7.88 | Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. ( Borges, K; Carrasco-Pozo, C; Simmons, D; Tan, KN, 2018) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 7.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 7.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE)." | 7.83 | Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus. ( Choi, HS; Lee, CH, 2016) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 7.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 7.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| "The aims of this study were to characterize the spatial distribution of neurodegeneration after status epilepticus (SE) induced by either systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of temporal lobe epilepsy (TLE), using FluoroJade (FJ) histochemistry, and to evaluate the kinetics of FJ staining in the H-PILO model." | 7.77 | Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats. ( Castro, OW; Fernandes, A; Furtado, MA; Garcia-Cairasco, N; Pajolla, GP; Tilelli, CQ, 2011) |
| "There is no direct correlation among cell activation, neuron degeneration and cell death in the hippocampus of mice after pilocarpine induced status epilepticus." | 7.77 | Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus. ( Liu, J; Liu, Y; Tang, F, 2011) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 7.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 7.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| " The effect of PDTC on status epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model." | 7.75 | Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. ( Fuest, C; Nickel, A; Pekcec, A; Potschka, H; Soerensen, J, 2009) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " In the present study in mGluR5 wild-type (mGluR5+/+) mice, we showed induced PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced SE; at 1 day, induced expression of PLCbeta4 in the stratum pyramidale of CA1 area was observed." | 7.74 | mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. ( Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2008) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| " Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE)." | 7.73 | Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. ( Borges, K; Dingledine, R; Irier, H; McDermott, D; Smith, Y, 2006) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 7.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 7.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " Recent studies have demonstrated an age-dependent induction of both p53 mRNA and protein in the rat brain following lithium-pilocarpine-mediated status epilepticus (LPSE)." | 7.71 | Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Tan, Z; Tu, W; Wasterlain, CG, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 7.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 7.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 7.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " We show here that another form of status epilepticus, induced by administration of the muscarinic agonist pilocarpine, produces changes in zinc that are essentially the same as those produced by the kainic acid-induced seizures." | 7.71 | Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. ( Frederickson, CJ; Suh, SW; Thompson, RB, 2001) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 7.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 7.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 7.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 7.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 5.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Ketamine post-SE onset treatment prevented neuronal death in all regions assessed." | 5.38 | Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats. ( Córdova, SD; de Oliveira, DL; Loss, CM, 2012) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 5.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "After tDCS, convulsions over 2 weeks were estimated by 20-h/day video monitoring." | 5.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 5.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 5.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "Pilocarpine was administered systemically (380mg/kg i." | 5.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| "Subsequently electrographic seizures appeared in both limbic and cortical leads." | 5.27 | Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. ( Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Schwarz, M; Turski, L; Turski, WA, 1983) |
| "Pilocarpine test has been used since long to study the functional status of sweat glands." | 5.26 | Pilocarpine test in assessment of therapeutic efficacy in maculoanaesthetic leprosy. ( Joshi, PB, 1976) |
| "Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model." | 4.84 | The pilocarpine model of temporal lobe epilepsy. ( Avoli, M; Biagini, G; Curia, G; Jones, RS; Longo, D, 2008) |
| "Rat models of epilepsy were induced by pilocarpine hydrochloride." | 3.88 | Disruption of GluR2/GAPDH Complex Interaction by TAT-GluR2 ( Liu, J; Mi, Q; Wang, J; Yao, G; Zhang, GY; Zhang, J; Zhao, P, 2018) |
| " Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice." | 3.88 | Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. ( Borges, K; Carrasco-Pozo, C; Simmons, D; Tan, KN, 2018) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 3.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 3.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE)." | 3.83 | Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus. ( Choi, HS; Lee, CH, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "Taken together, this highlights pilocarpine through the activation of muscarinic receptors appear to afford significant protection against retinal neurons damage and optic nerve degeneration at clinically relevant concentrations." | 3.80 | Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models. ( Chen, HZ; Cui, YY; Feng, XM; Li, H; Qiu, Y; Tan, PP; Yuan, HH; Zhou, W; Zhu, X, 2014) |
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 3.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 3.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| " We found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely." | 3.79 | Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ( Dingledine, R; Dudek, FE; Ganesh, T; Jiang, J; Pouliot, WA; Quan, Y, 2013) |
| "The aims of this study were to characterize the spatial distribution of neurodegeneration after status epilepticus (SE) induced by either systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of temporal lobe epilepsy (TLE), using FluoroJade (FJ) histochemistry, and to evaluate the kinetics of FJ staining in the H-PILO model." | 3.77 | Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats. ( Castro, OW; Fernandes, A; Furtado, MA; Garcia-Cairasco, N; Pajolla, GP; Tilelli, CQ, 2011) |
| "There is no direct correlation among cell activation, neuron degeneration and cell death in the hippocampus of mice after pilocarpine induced status epilepticus." | 3.77 | Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus. ( Liu, J; Liu, Y; Tang, F, 2011) |
| " Prolonged seizures (status epilepticus, SE) were induced by pilocarpine." | 3.77 | Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus. ( Cardoso, A; Lukoyanov, NV; Lukoyanova, EA; Madeira, MD, 2011) |
| " To better define the role of increased homocysteine in epilepsy, we analyzed the effects of homocysteine pretreatment in the pilocarpine model of status epilepticus (SE), which is used to mimic temporal lobe epilepsy (TLE) in rodents." | 3.76 | Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment. ( Agnati, LF; Andreoli, N; Baldelli, E; Biagini, G; Fuxe, K; Leo, G, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 3.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 3.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| " The effect of PDTC on status epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model." | 3.75 | Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. ( Fuest, C; Nickel, A; Pekcec, A; Potschka, H; Soerensen, J, 2009) |
| " The recordings were performed in epileptic rats 24 h after an early behavioural spontaneous seizure between 5 and 21 days after pilocarpine-induced status epilepticus." | 3.74 | Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. ( Mello, LE; Queiroz, CM, 2007) |
| " In the present study in mGluR5 wild-type (mGluR5+/+) mice, we showed induced PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced SE; at 1 day, induced expression of PLCbeta4 in the stratum pyramidale of CA1 area was observed." | 3.74 | mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. ( Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " Seizures were induced by pilocarpine (400 mg/kg; i." | 3.73 | Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat. ( Basta-Kaim, A; Budziszewska, B; Dziedzicka-Wasylewska, M; Jaworska-Feil, L; Kubera, M; Kuśmider, M; Kutner, A; Lasoń, W; Leśkiewicz, M; Myint, AM; Skowroński, M; Tetich, M, 2005) |
| "Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats." | 3.73 | Changes of cortical interhemispheric responses after status epilepticus in immature rats. ( Aleksakhina, K; Druga, R; Kubová, H; Mares, P; Tsenov, G, 2005) |
| " Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE)." | 3.73 | Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. ( Borges, K; Dingledine, R; Irier, H; McDermott, D; Smith, Y, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "We used pilocarpine-induced seizures in mice to determine the impact of genetic background on the vulnerability of hippocampal neurons and associated changes of behavioral performance." | 3.72 | The impact of genetic background on neurodegeneration and behavior in seizured mice. ( Lipp, HP; Madani, R; Mohajeri, MH; Nitsch, RM; Saini, K; Wolfer, DP, 2004) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 3.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 3.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " After pilocarpine-induced status epilepticus (SE) in mice most hilar neurons died and neuropeptide Y (NPY) immunoreactivity appeared in the dentate inner molecular layer (IML) after 10-31 days indicative of MFS." | 3.72 | Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice. ( Borges, K; Dingledine, R; McDermott, DL, 2004) |
| " We show here that another form of status epilepticus, induced by administration of the muscarinic agonist pilocarpine, produces changes in zinc that are essentially the same as those produced by the kainic acid-induced seizures." | 3.71 | Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. ( Frederickson, CJ; Suh, SW; Thompson, RB, 2001) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 3.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 3.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 3.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| " Recent studies have demonstrated an age-dependent induction of both p53 mRNA and protein in the rat brain following lithium-pilocarpine-mediated status epilepticus (LPSE)." | 3.71 | Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Tan, Z; Tu, W; Wasterlain, CG, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 3.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| "Time-dependent atrophy of cerebral space and enlargement of the lateral ventricles were noted in healthy rats 1 to 100 days after the induction of seizures by a single systemic injection of lithium and pilocarpine." | 3.70 | Ventricular dilation over several weeks following induction of excitotoxic (systemic lithium/pilocarpine) lesions: potential role of damage to the substantia nigra reticulata. ( Desjardins, D; Eastman, A; Peredery, O; Persinger, MA, 1998) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 3.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "In the rat pilocarpine model, dendrites of DGCs revealed a generalized spine loss immediately after the acute status epilepticus induced by pilocarpine." | 3.70 | Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model. ( Isokawa, M, 2000) |
| " In the present study, we explored the correlation between metabolic changes, neuronal damage, and epileptogenesis during the silent and chronic phases after status epilepticus (SE) induced by lithium-pilocarpine in 10-day-old (P10), 21-day-old (P21), and adult rats." | 3.70 | A metabolic and neuropathological approach to the understanding of plastic changes that occur in the immature and adult rat brain during lithium-pilocarpine-induced epileptogenesis. ( Dubé, C; Marescaux, C; Nehlig, A, 2000) |
| "Multivariate analyses between conditioned taste aversion (CTA) and radial maze acquisition (RMA) scores and percentages of neuronal dropout within thalamic and telencephalic structures were completed for rats in which overt seizures had been evoked following a single systemic injection of lithium/pilocarpine." | 3.69 | Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 3.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 3.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "In this study, we observed the seizure behavior induced by kainic acid (20 mg/kg or 30 mg/kg) or pilocarpine (350 mg/kg) in AC8 KO and wild-type mice." | 1.43 | A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice. ( Chen, X; Dong, G; Wang, H; Yun, W; Zheng, C; Zhou, X, 2016) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 1.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 1.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "Ketamine post-SE onset treatment prevented neuronal death in all regions assessed." | 1.38 | Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats. ( Córdova, SD; de Oliveira, DL; Loss, CM, 2012) |
| "After tDCS, convulsions over 2 weeks were estimated by 20-h/day video monitoring." | 1.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 1.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "The data indicate that seizure-induced glutamate release is involved in the regulation of Pgp expression, which can be blocked by MK-801." | 1.35 | Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. ( Bankstahl, JP; Bethmann, K; Hoffmann, K; Löscher, W, 2008) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 1.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "Many animals developed seizures of varying severity and length." | 1.32 | Neuropathology of seizures in the immature rabbit. ( Brucklacher, R; Housman, C; Towfighi, J; Vannucci, RC, 2004) |
| "Pilocarpine was administered systemically (380mg/kg i." | 1.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| " In addition, long-term administration of high-dose topiramate in the normal developing rat brain does not appear to impair cognitive performance." | 1.31 | Effect of topiramate following recurrent and prolonged seizures during early development. ( Cha, BH; Holmes, GL; Hu, Y; Liu, X; Silveira, DC, 2002) |
| "Subsequently electrographic seizures appeared in both limbic and cortical leads." | 1.27 | Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. ( Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Schwarz, M; Turski, L; Turski, WA, 1983) |
| "Pilocarpine test has been used since long to study the functional status of sweat glands." | 1.26 | Pilocarpine test in assessment of therapeutic efficacy in maculoanaesthetic leprosy. ( Joshi, PB, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (4.76) | 18.7374 |
| 1990's | 13 (12.38) | 18.2507 |
| 2000's | 47 (44.76) | 29.6817 |
| 2010's | 40 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vizuete, AFK | 1 |
| Hennemann, MM | 1 |
| Gonçalves, CA | 1 |
| de Oliveira, DL | 3 |
| Ko, AR | 1 |
| Kang, TC | 4 |
| Tan, KN | 2 |
| Simmons, D | 1 |
| Carrasco-Pozo, C | 2 |
| Borges, K | 4 |
| Mi, Q | 1 |
| Yao, G | 1 |
| Zhang, GY | 1 |
| Zhang, J | 1 |
| Wang, J | 1 |
| Zhao, P | 1 |
| Liu, J | 2 |
| Zhu, S | 1 |
| Tai, C | 1 |
| Petkau, TL | 1 |
| Zhang, S | 1 |
| Liao, C | 1 |
| Dong, Z | 1 |
| Wen, W | 1 |
| Chang, Q | 1 |
| Tian Wang, Y | 1 |
| MacVicar, BA | 1 |
| Leavitt, BR | 1 |
| Jia, W | 1 |
| Cynader, MS | 1 |
| Scholl, EA | 1 |
| Dudek, FE | 2 |
| Ekstrand, JJ | 1 |
| Tan, PP | 1 |
| Yuan, HH | 1 |
| Zhu, X | 1 |
| Cui, YY | 1 |
| Li, H | 1 |
| Feng, XM | 1 |
| Qiu, Y | 1 |
| Chen, HZ | 1 |
| Zhou, W | 1 |
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Papageorgiou, IE | 1 |
| Fetani, AF | 1 |
| Lewen, A | 1 |
| Heinemann, U | 1 |
| Kann, O | 1 |
| Wei, D | 1 |
| Yang, F | 2 |
| Wang, Y | 1 |
| Wu, C | 1 |
| Wu, SX | 1 |
| Jiang, W | 1 |
| García-García, L | 1 |
| Shiha, AA | 1 |
| Bascuñana, P | 1 |
| de Cristóbal, J | 1 |
| Fernández de la Rosa, R | 1 |
| Delgado, M | 1 |
| Pozo, MA | 1 |
| Suchomelova, L | 1 |
| Lopez-Meraz, ML | 2 |
| Niquet, J | 2 |
| Kubova, H | 4 |
| Wasterlain, CG | 4 |
| Choi, HS | 1 |
| Lee, CH | 1 |
| Chen, X | 1 |
| Dong, G | 1 |
| Zheng, C | 1 |
| Wang, H | 1 |
| Yun, W | 1 |
| Zhou, X | 1 |
| Melo, IS | 1 |
| Santos, YMO | 1 |
| Costa, MA | 1 |
| Pacheco, ALD | 1 |
| Silva, NKGT | 1 |
| Cardoso-Sousa, L | 1 |
| Pereira, UP | 1 |
| Goulart, LR | 1 |
| Garcia-Cairasco, N | 2 |
| Duzzioni, M | 1 |
| Gitaí, DLG | 1 |
| Tilelli, CQ | 2 |
| Sabino-Silva, R | 1 |
| Castro, OW | 2 |
| Motaghi, S | 1 |
| Sayyah, M | 1 |
| Babapour, V | 1 |
| Mahdian, R | 1 |
| Curia, G | 1 |
| Longo, D | 1 |
| Biagini, G | 2 |
| Jones, RS | 1 |
| Avoli, M | 1 |
| Hanaya, R | 1 |
| Koning, E | 2 |
| Ferrandon, A | 4 |
| Nehlig, A | 8 |
| Wang, L | 2 |
| Liu, YH | 2 |
| Huang, YG | 3 |
| Chen, LW | 2 |
| Liu, JX | 1 |
| Tang, YC | 1 |
| Liu, Y | 2 |
| Tang, FR | 1 |
| Becker, AJ | 2 |
| Pitsch, J | 2 |
| Sochivko, D | 1 |
| Opitz, T | 1 |
| Staniek, M | 1 |
| Chen, CC | 1 |
| Campbell, KP | 1 |
| Schoch, S | 2 |
| Yaari, Y | 1 |
| Beck, H | 1 |
| Wei, LC | 1 |
| Kim, JE | 3 |
| Kwak, SE | 1 |
| Jo, SM | 1 |
| Andrioli, A | 2 |
| Fabene, PF | 4 |
| Spreafico, R | 1 |
| Cavalheiro, EA | 7 |
| Bentivoglio, M | 4 |
| Chang, IY | 1 |
| Kim, JK | 1 |
| Lee, SM | 1 |
| Kim, JN | 1 |
| Soh, J | 1 |
| Kim, JW | 1 |
| Yoon, SP | 1 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 1 |
| Dykstra, CM | 1 |
| Ratnam, M | 1 |
| Gurd, JW | 1 |
| Militão, GC | 1 |
| Ferreira, PM | 1 |
| de Freitas, RM | 1 |
| Soerensen, J | 1 |
| Pekcec, A | 1 |
| Fuest, C | 1 |
| Nickel, A | 1 |
| Potschka, H | 1 |
| Rocha, LL | 1 |
| Allen, S | 1 |
| Ndode-Ekane, XE | 1 |
| Hayward, N | 1 |
| Gröhn, O | 1 |
| Pitkänen, A | 2 |
| Chen, S | 2 |
| Fujita, S | 1 |
| Koshikawa, N | 1 |
| Kobayashi, M | 1 |
| Baldelli, E | 1 |
| Leo, G | 1 |
| Andreoli, N | 1 |
| Fuxe, K | 1 |
| Agnati, LF | 1 |
| Thind, KK | 1 |
| Yamawaki, R | 1 |
| Phanwar, I | 1 |
| Zhang, G | 1 |
| Wen, X | 1 |
| Buckmaster, PS | 1 |
| Druga, R | 2 |
| Mares, P | 2 |
| Ryu, HJ | 2 |
| Kim, MJ | 1 |
| Kwon, HJ | 1 |
| Suh, SW | 2 |
| Song, HK | 1 |
| Pestana, RR | 1 |
| Kinjo, ER | 1 |
| Hernandes, MS | 1 |
| Britto, LR | 1 |
| Kamida, T | 1 |
| Kong, S | 1 |
| Eshima, N | 1 |
| Abe, T | 1 |
| Fujiki, M | 1 |
| Kobayashi, H | 1 |
| Bavaresco, C | 1 |
| Mussulini, BH | 1 |
| Fischer, A | 1 |
| Souza, DO | 1 |
| Wyse, AT | 1 |
| Wofchuk, S | 1 |
| Long, L | 1 |
| Xiao, B | 1 |
| Feng, L | 1 |
| Yi, F | 1 |
| Li, G | 1 |
| Li, S | 1 |
| Mutasem, MA | 1 |
| Bi, F | 1 |
| Li, Y | 1 |
| Furtado, MA | 1 |
| Fernandes, A | 1 |
| Pajolla, GP | 1 |
| Cardoso, A | 1 |
| Lukoyanova, EA | 1 |
| Madeira, MD | 1 |
| Lukoyanov, NV | 1 |
| Rosim, FE | 1 |
| Persike, DS | 1 |
| Amorim, RP | 1 |
| de Oliveira, DM | 1 |
| Fernandes, MJ | 2 |
| Tang, F | 1 |
| Al-Shorbagy, MY | 1 |
| El Sayeh, BM | 1 |
| Abdallah, DM | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 2 |
| Löscher, W | 2 |
| do Nascimento, AL | 1 |
| Dos Santos, NF | 1 |
| Campos Pelágio, F | 1 |
| Aparecida Teixeira, S | 1 |
| de Moraes Ferrari, EA | 1 |
| Langone, F | 1 |
| Hoehna, Y | 1 |
| Uckermann, O | 1 |
| Luksch, H | 1 |
| Stefovska, V | 1 |
| Marzahn, J | 1 |
| Theil, M | 1 |
| Gorkiewicz, T | 1 |
| Gawlak, M | 1 |
| Wilczynski, GM | 1 |
| Kaczmarek, L | 1 |
| Ikonomidou, C | 1 |
| Loss, CM | 1 |
| Córdova, SD | 1 |
| Kim, DS | 1 |
| Jiang, J | 1 |
| Quan, Y | 1 |
| Ganesh, T | 1 |
| Pouliot, WA | 1 |
| Dingledine, R | 3 |
| Cha, BH | 1 |
| Silveira, DC | 1 |
| Liu, X | 1 |
| Hu, Y | 1 |
| Holmes, GL | 1 |
| Houser, CR | 2 |
| Esclapez, M | 2 |
| NEKLESOVA, ID | 1 |
| OSIPOVA, ZM | 1 |
| McDermott, DL | 1 |
| Mohajeri, MH | 1 |
| Madani, R | 1 |
| Saini, K | 1 |
| Lipp, HP | 1 |
| Nitsch, RM | 1 |
| Wolfer, DP | 1 |
| Persinger, MA | 7 |
| Dupont, MJ | 1 |
| Towfighi, J | 1 |
| Housman, C | 1 |
| Brucklacher, R | 1 |
| Vannucci, RC | 1 |
| Priel, MR | 1 |
| Tetich, M | 1 |
| Dziedzicka-Wasylewska, M | 1 |
| Kuśmider, M | 1 |
| Kutner, A | 1 |
| Leśkiewicz, M | 1 |
| Jaworska-Feil, L | 1 |
| Budziszewska, B | 1 |
| Kubera, M | 1 |
| Myint, AM | 1 |
| Basta-Kaim, A | 1 |
| Skowroński, M | 1 |
| Lasoń, W | 1 |
| Tsenov, G | 1 |
| Aleksakhina, K | 1 |
| Nairismägi, J | 1 |
| Kettunen, MI | 1 |
| Kauppinen, RA | 1 |
| Voutsinos-Porche, B | 1 |
| Clément, Y | 1 |
| Kaplan, H | 1 |
| Motte, J | 1 |
| Setkowicz, Z | 1 |
| Majcher, K | 1 |
| Janicka, D | 1 |
| Sułek, Z | 1 |
| Skórka, T | 1 |
| Jasiński, A | 1 |
| Janeczko, K | 1 |
| McDermott, D | 1 |
| Irier, H | 1 |
| Smith, Y | 1 |
| Garrido Sanabria, ER | 1 |
| Castañeda, MT | 1 |
| Banuelos, C | 1 |
| Perez-Cordova, MG | 1 |
| Hernandez, S | 1 |
| Colom, LV | 1 |
| Chakir, A | 1 |
| Ouazzani, R | 1 |
| Gueler, N | 1 |
| Flor, PJ | 1 |
| van der Putten, H | 1 |
| Marqués-Marí, AI | 1 |
| Nacher, J | 1 |
| Crespo, C | 1 |
| Gutièrrez-Mecinas, M | 1 |
| Martínez-Guijarro, FJ | 1 |
| Blasco-Ibáñez, JM | 1 |
| Queiroz, CM | 1 |
| Mello, LE | 3 |
| Jesse, CR | 1 |
| Savegnago, L | 1 |
| Rocha, JB | 1 |
| Nogueira, CW | 1 |
| Yu, X | 1 |
| Shao, XG | 1 |
| Sun, H | 1 |
| Li, YN | 1 |
| Yang, J | 1 |
| Deng, YC | 1 |
| Hoffmann, K | 1 |
| Bethmann, K | 1 |
| Turski, WA | 2 |
| Schwarz, M | 1 |
| Czuczwar, SJ | 2 |
| Kleinrok, Z | 2 |
| Turski, L | 2 |
| Milart, P | 1 |
| Turski, W | 1 |
| Czuczwar, S | 1 |
| Bureau, YR | 2 |
| Peredery, O | 4 |
| Obenaus, A | 1 |
| Kostakos, M | 1 |
| Falter, H | 1 |
| Cook, LL | 2 |
| Corso, TD | 2 |
| Sesma, MA | 1 |
| Tenkova, TI | 1 |
| Der, TC | 1 |
| Wozniak, DF | 2 |
| Farber, NB | 1 |
| Olney, JW | 2 |
| Lemos, T | 1 |
| Isokawa, M | 2 |
| Desjardins, D | 2 |
| Eastman, A | 1 |
| Dubé, C | 4 |
| André, V | 2 |
| Covolan, L | 1 |
| Marescaux, C | 5 |
| Boyet, S | 2 |
| Dikranian, K | 1 |
| Ishimaru, MJ | 1 |
| Nardi, A | 1 |
| Tenkova, T | 1 |
| Fix, AS | 1 |
| Poirier, JL | 1 |
| Capek, R | 1 |
| De Koninck, Y | 1 |
| Thompson, RB | 1 |
| Frederickson, CJ | 1 |
| Parker, G | 2 |
| Correia, L | 1 |
| Carvalho, RA | 1 |
| Wu, CL | 2 |
| Huang, LT | 2 |
| Liou, CW | 2 |
| Wang, TJ | 2 |
| Tung, YR | 1 |
| Hsu, HY | 1 |
| Lai, MC | 2 |
| Tan, Z | 2 |
| Sankar, R | 2 |
| Shin, D | 2 |
| Sun, N | 1 |
| Liu, H | 2 |
| Schreiber, SS | 2 |
| Tu, W | 1 |
| Bozzi, Y | 1 |
| Borrelli, E | 1 |
| Hamani, C | 1 |
| Yang, SN | 1 |
| Hung, PL | 1 |
| Cheng, SC | 1 |
| Joshi, PB | 1 |
| Tan, AM | 1 |
| Pretorius, JK | 1 |
| Babb, TL | 1 |
| Finch, DM | 1 |
| Blomme, C | 1 |
| Sieklucka-Dziuba, M | 1 |
| Ikonomidou-Turski, C | 1 |
1 review available for pilocarpine and Nerve Degeneration
| Article | Year |
|---|---|
The pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal L | 2008 |
104 other studies available for pilocarpine and Nerve Degeneration
| Article | Year |
|---|---|
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Nerve De | 2017 |
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation.
Topics: Animals; Butadienes; Disease Models, Animal; Dynamins; Enzyme Inhibitors; Male; Mitochondria; Mitoch | 2017 |
Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Citric Acid Cycle; Convu | 2018 |
Disruption of GluR2/GAPDH Complex Interaction by TAT-GluR2
Topics: Amino Acid Sequence; Animals; Cell Death; Cell Nucleus; Epilepsy; Glyceraldehyde-3-Phosphate Dehydro | 2018 |
Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Dentate Gyrus; Disease Models, Animal; Granulins; Hippocampus; Intercellular Si | 2013 |
Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Hippocampus; Lithium; Nerve Degeneration; Piloc | 2013 |
Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.
Topics: Animals; Animals, Newborn; Caspase 3; Cells, Cultured; Choline O-Acetyltransferase; Disease Models, | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; CD11b Antigen; Cell Count; Chronic Disease; | 2015 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats.
Topics: Animals; Disease Models, Animal; Fenclonine; Gliosis; Hippocampus; Lithium; Magnetic Resonance Imagi | 2016 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Gene Expression Regulation; Hippocalcin; Hippocampus; Male; Mice; Mice, Inbred ICR; Nerve D | 2016 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Aci | 2016 |
Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus.
Topics: Animals; Hippocampus; Male; Nerve Degeneration; Neurons; Phlorhizin; Pilocarpine; Rats; Rats, Wistar | 2016 |
Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
Topics: Animals; Connexin 43; Connexins; Disease Models, Animal; Epilepsy; Gap Junction delta-2 Protein; Hip | 2017 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Topics: Animals; Disease Progression; Female; Gene Deletion; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mi | 2008 |
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.
Topics: Animals; Calcium Channels, T-Type; Calcium Signaling; Channelopathies; Disease Models, Animal; Epile | 2008 |
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner | 2009 |
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures.
Topics: Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroencephalo | 2009 |
The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.
Topics: Active Transport, Cell Nucleus; Animals; Carrier Proteins; Cell Nucleus; Cholesterol; Convulsants; C | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Neuroprotection after status epilepticus by targeting protein interactions with postsynaptic density protein 95.
Topics: Animals; Cell Count; Cell Death; Disks Large Homolog 4 Protein; Hippocampus; Immunohistochemistry; I | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model.
Topics: Animals; Antioxidants; Cell Count; Cytoprotection; Female; Hippocampus; Nerve Degeneration; Neurons; | 2009 |
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calbin | 2010 |
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy.
Topics: Animals; Antigens; Blood-Brain Barrier; Capillaries; Cell Proliferation; Convulsants; Disease Models | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; F | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Time course of neuronal damage in the hippocampus following lithium-pilocarpine status epilepticus in 12-day-old rats.
Topics: Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Hippocampus; Lithium Chloride; Mal | 2010 |
The protective effects of interleukin-18 and interferon-γ on neuronal damages in the rat hippocampus following status epilepticus.
Topics: Animals; Astrocytes; Disease Models, Animal; Hippocampus; Infusions, Intraventricular; Interferon ga | 2010 |
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Death; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male | 2010 |
Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; Electric Stimulation Therapy; Hippocampus; Lithium Chloride; Male; | 2011 |
Early life LiCl-pilocarpine-induced status epilepticus reduces acutely hippocampal glutamate uptake and Na+/K+ ATPase activity.
Topics: Animals; Convulsants; Enzyme Activation; Glutamic Acid; Hippocampus; Lithium Chloride; Male; Nerve D | 2011 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats.
Topics: Animals; Fluoresceins; Fluorescent Dyes; Hippocampus; Male; Microinjections; Nerve Degeneration; Org | 2011 |
Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.
Topics: Animals; Avoidance Learning; Cell Count; Electroshock; Hippocampus; Male; Maze Learning; Nerve Degen | 2011 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactio | 2011 |
Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus.
Topics: Animals; Cell Death; Hippocampus; Male; Mice; Nerve Degeneration; Neurons; Pilocarpine; Status Epile | 2011 |
Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; CA3 Region, Hippocampal; Dexamethasone; Dinoprostone; Diseas | 2012 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2012 |
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Disease Progression; Fluoresceins | 2012 |
Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Convulsants; Humans; Immunohistochemistry; In Situ Nic | 2012 |
Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats.
Topics: Animals; Anxiety; Brain; Convulsants; Ketamine; Male; Nerve Degeneration; Neuroprotective Agents; Pi | 2012 |
The reverse roles of transient receptor potential canonical channel-3 and -6 in neuronal death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Male; Nerve Degeneration; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Sta | 2013 |
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Disease Models, Animal; Hippocampus; Humans; I | 2013 |
Effect of topiramate following recurrent and prolonged seizures during early development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cell Death; Cognition; Convulsants; Disease | 2002 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
[ON THE MECHANISM OF ACTION OF CERTAIN ORGANOPHOSPHORIC MIOTICS].
Topics: Animals; Cats; Cholinesterase Inhibitors; Lagomorpha; Miotics; Nerve Degeneration; Pharmacology; Pho | 1964 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cone | 2004 |
The impact of genetic background on neurodegeneration and behavior in seizured mice.
Topics: Animals; Cell Death; Convulsants; Crosses, Genetic; Exploratory Behavior; Genetic Predisposition to | 2004 |
Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices.
Topics: Animals; Cell Survival; Epilepsy; Functional Laterality; Lithium; Male; Nerve Degeneration; Neurons; | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypote | 2004 |
Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures.
Topics: Animals; Cell Count; Epilepsy; Genes, fos; Hippocampus; Immunohistochemistry; Interneurons; Muscarin | 2004 |
Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Calcitriol; Calcium; Cell Proliferation; Dihydrox | 2005 |
Changes of cortical interhemispheric responses after status epilepticus in immature rats.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Electric Stimulation; Fluoresceins; Fluorescent Dyes; Fun | 2005 |
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study.
Topics: Amygdala; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Entorhinal Cortex; Fluoresce | 2006 |
EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Chemistry; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 3; Fluor | 2006 |
Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Female; Gestational Age; Magnetic R | 2006 |
Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Cell Count; Cell Proliferation; Dentate Gyrus; Glial Fibrillary Acidic Protein; | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Ge | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study.
Topics: Action Potentials; Animals; Cell Death; Convulsants; Cortical Synchronization; Disease Models, Anima | 2007 |
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Resp | 2008 |
Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus.
Topics: Animals; Benzamides; Cell Death; Convulsants; Disease Models, Animal; Glutathione; Heme Oxygenase (D | 2008 |
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capill | 2008 |
Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentia | 1983 |
Effects of atropine, pilocarpine and morphine on footshock-induced aggressive behaviour in rats after lesion of hippocampal pyramidal cells with kainic acid.
Topics: Aggression; Animals; Atropine; Drug Interactions; Electroshock; Hippocampus; Humans; Kainic Acid; Ma | 1982 |
Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory.
Topics: Animals; Avoidance Learning; Brain Damage, Chronic; Brain Mapping; Conditioning, Classical; Dose-Res | 1994 |
Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures.
Topics: Animals; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry | 1993 |
Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Topics: Acetylcholine; Aggression; Animals; Association Learning; Avoidance Learning; Brain; Brain Damage, C | 1993 |
Demands during maze. learning in limbic epileptic rats: selective damage in the thalamus?
Topics: Animals; Attention; Brain Mapping; Cell Count; Epilepsy; Limbic System; Lithium; Male; Maze Learning | 1996 |
Multifocal brain damage induced by phencyclidine is augmented by pilocarpine.
Topics: Animals; Brain; Brain Damage, Chronic; Dose-Response Relationship, Drug; Drug Synergism; Female; Ner | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Membrane time constant as a tool to assess cell degeneration.
Topics: Animals; Cell Membrane; Dendrites; Dentate Gyrus; Electric Conductivity; Electric Impedance; Epileps | 1997 |
Ventricular dilation over several weeks following induction of excitotoxic (systemic lithium/pilocarpine) lesions: potential role of damage to the substantia nigra reticulata.
Topics: Animals; Atrophy; Brain; Cerebral Ventricles; Lithium; Male; Nerve Degeneration; Neurotoxins; Piloca | 1998 |
C-Fos, Jun D and HSP72 immunoreactivity, and neuronal injury following lithium-pilocarpine induced status epilepticus in immature and adult rats.
Topics: Age Factors; Animals; Brain Stem; Cerebral Cortex; Female; Heat-Shock Proteins; Hippocampus; HSP72 H | 1998 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerv | 1999 |
Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Dizocilpine Maleate; Drug Combinations; Excitatory Amin | 1998 |
Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult Rat.
Topics: Age Factors; Animals; Behavior, Animal; Benzoxazines; Brain Stem; Carbon Radioisotopes; Cell Death; | 2000 |
Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Brain Mapping; Cell Count; Cell Death; Fluorescent Dyes; Gliosis; Hippoca | 2000 |
Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Lysine; Male; Mo | 2000 |
A metabolic and neuropathological approach to the understanding of plastic changes that occur in the immature and adult rat brain during lithium-pilocarpine-induced epileptogenesis.
Topics: Age Factors; Animals; Brain; Female; Glucose; Lithium; Male; Nerve Degeneration; Neuronal Plasticity | 2000 |
The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Electroshock; Kindling, Neurologi | 2000 |
Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine.
Topics: Aminoquinolines; Animals; Fluorescent Dyes; Male; Muscarinic Agonists; Nerve Degeneration; Neurons; | 2001 |
Agonistic behavior in groups of limbic epileptic male rats: pattern of brain damage and moderating effects from normal rats.
Topics: Agonistic Behavior; Animals; Antimanic Agents; Behavior, Animal; Brain Injuries; Cerebral Cortex; Co | 2001 |
The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Disease Models, Animal; Epilepsy; Glutamate Decarboxyl | 2001 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; | 2001 |
Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Brain; Caspase 3; Caspases; Cholinergic Agents; | 2002 |
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Carbon-Oxygen Lyases; C | 2002 |
Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.
Topics: Acetylcholine; Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Epilepsy; Ex | 2002 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Topics: Aging; Aminophylline; Animals; Cell Differentiation; Cognition Disorders; Growth Cones; Hippocampus; | 2002 |
Pilocarpine test in assessment of therapeutic efficacy in maculoanaesthetic leprosy.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Leprosy; Male; | 1976 |
Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy.
Topics: Animals; Cell Count; Cytoplasmic Granules; Electroencephalography; Epilepsy, Temporal Lobe; Hippocam | 1992 |
Absence of maternal behavior in rats with lithium/pilocarpine seizure-induced brain damage: support of MacLean's triune brain theory.
Topics: Animals; Brain; Brain Mapping; Cerebral Cortex; Chlorides; Electroencephalography; Evoked Potentials | 1992 |
Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Electroencephalography; Glutamate Decarboxylase; Male; N | 1986 |