Page last updated: 2024-11-07

pilocarpine and Neoplasms

pilocarpine has been researched along with Neoplasms in 12 studies

Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"This was a crossover study comparing a mucin-based artificial saliva (Saliva Orthana) and pilocarpine hydrochloride (Salagen) in the management of xerostomia in patients with advanced cancer."9.08A comparison of artificial saliva and pilocarpine in the management of xerostomia in patients with advanced cancer. ( Daniels, C; Davies, AN; Pugh, R; Sharma, K, 1998)
"This was a crossover study comparing a mucin-based artificial saliva (Saliva Orthana) and pilocarpine hydrochloride (Salagen) in the management of xerostomia in patients with advanced cancer."5.08A comparison of artificial saliva and pilocarpine in the management of xerostomia in patients with advanced cancer. ( Daniels, C; Davies, AN; Pugh, R; Sharma, K, 1998)
"Pilocarpine is a cholinergic agent that promotes salivation."2.80Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study. ( Agar, M; Carmont, SA; Currow, D; Good, P; Hardy, J; Mitchell, GK; Nikles, J; Schluter, PJ; Senior, H; Vora, R, 2015)
"D."2.71Mutans streptococci in xerostomic cancer patients after pilocarpine therapy: a pilot study. ( Chambers, MS; Gallagher, SC; Keene, HJ; Lemon, JC; Martin, CG; Martin, JW; Toth, BB, 2005)
"Dry mouth (xerostomia) is one of the commonest symptoms in cancer patients and can adversely affect quality of life."2.52Systematic literature review: xerostomia in advanced cancer patients. ( Adkinson, L; Daniel, S; Fleming, M; Hanchanale, S; Oxberry, SG, 2015)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's2 (16.67)18.2507
2000's5 (41.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hanchanale, S1
Adkinson, L1
Daniel, S1
Fleming, M1
Oxberry, SG1
Nikles, J1
Mitchell, GK1
Hardy, J1
Agar, M1
Senior, H1
Carmont, SA1
Schluter, PJ1
Good, P1
Vora, R1
Currow, D1
Nieuw Amerongen, AV1
Veerman, EC1
SCHNEYER, CA1
PUCHKOV, NV1
FIRSOVA, PP1
Chambers, MS1
Keene, HJ1
Toth, BB1
Lemon, JC1
Gallagher, SC1
Martin, CG1
Martin, JW1
Davies, AN1
Daniels, C1
Pugh, R1
Sharma, K1
Mercadante, S1
Calderone, L1
Villari, P1
Serretta, R1
Sapio, M1
Casuccio, A1
Fulfaro, F1
Mead, GM1
Kent, S1
Wolff, A1
Atkinson, JC1
Macynski, AA1
Fox, PC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Pilocarpine in Patients With Xerostomia[NCT02982577]Phase 480 participants (Anticipated)Interventional2016-04-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for pilocarpine and Neoplasms

ArticleYear
Systematic literature review: xerostomia in advanced cancer patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015, Volume: 23, Issue:3

    Topics: Acupuncture Therapy; Adult; Chewing Gum; Disease Progression; Humans; Neoplasms; Pilocarpine; Prospe

2015
Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2003, Volume: 11, Issue:4

    Topics: Acupuncture Therapy; Antineoplastic Agents; Chewing Gum; Diet; Flavoring Agents; Humans; Muscarinic

2003
Oral complications of cancer therapies. Pretherapy interventions to modify salivary dysfunction.
    NCI monographs : a publication of the National Cancer Institute, 1990, Issue:9

    Topics: Antineoplastic Agents; Humans; Neoplasms; Pilocarpine; Radiotherapy; Salivary Glands

1990

Trials

3 trials available for pilocarpine and Neoplasms

ArticleYear
Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study.
    Palliative medicine, 2015, Volume: 29, Issue:10

    Topics: Administration, Buccal; Cell Transformation, Neoplastic; Cholinergic Agents; Cross-Over Studies; Fea

2015
Mutans streptococci in xerostomic cancer patients after pilocarpine therapy: a pilot study.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2005, Volume: 99, Issue:2

    Topics: Analgesics, Opioid; Colony Count, Microbial; Female; Follow-Up Studies; Humans; Longitudinal Studies

2005
A comparison of artificial saliva and pilocarpine in the management of xerostomia in patients with advanced cancer.
    Palliative medicine, 1998, Volume: 12, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Female; Home Care Services; Hospitalization; Hum

1998

Other Studies

6 other studies available for pilocarpine and Neoplasms

ArticleYear
The effect of pilocarpine on tumor growth.
    Cancer research, 1957, Volume: 17, Issue:4

    Topics: Animals; Neoplasms; Neoplasms, Experimental; Pilocarpine

1957
[Effect of parasympathicotropic substances on the phagocyte activity of leukocytes in patients with cancer (preliminary report)].
    Biulleten' eksperimental'noi biologii i meditsiny, 1963, Volume: 55(3)

    Topics: Humans; Leukocytes; Neoplasms; Phagocytes; Phagocytosis; Pilocarpine

1963
New approaches to preventing xerostomia.
    The journal of supportive oncology, 2006, Volume: 4, Issue:2

    Topics: Amifostine; Cytoprotection; Humans; Muscarinic Agonists; Neoplasms; Pilocarpine; Quinuclidines; Radi

2006
The use of pilocarpine in opioid-induced xerostomia.
    Palliative medicine, 2000, Volume: 14, Issue:6

    Topics: Administration, Oral; Aged; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Narcotics; Neopl

2000
Management of oral mucositis associated with cancer chemotherapy.
    Lancet (London, England), 2002, Mar-09, Volume: 359, Issue:9309

    Topics: Antineoplastic Agents; Humans; Ice; Mouth Mucosa; Muscarinic Agonists; Neoplasms; Oral Hygiene; Pilo

2002
Continuous drug delivery methods reflect progress in therapy for chronic diseases.
    Geriatrics, 1977, Volume: 32, Issue:9

    Topics: Aged; Chronic Disease; Cytarabine; Dosage Forms; Drug Implants; Glaucoma; Humans; Injections, Intrav

1977