pilocarpine has been researched along with Mouth Diseases in 4 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Mouth Diseases: Diseases involving the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) act outwith the haemopoeitic system and can reduce mucositis, but the best schedule, dosage and method of administration is not known or which is the best growth factor to prevent this side-effect." | 2.40 | Treatment-induced mucositis: an old problem with new remedies. ( Symonds, RP, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pariser, DM | 1 |
| Krishnaraja, J | 1 |
| Tremblay, TM | 1 |
| Rubison, RM | 1 |
| Love, TW | 1 |
| McGraw, BF | 1 |
| Vissink, A | 1 |
| Burlage, FR | 1 |
| Spijkervet, FK | 1 |
| Jansma, J | 1 |
| Coppes, RP | 1 |
| Fox, PC | 1 |
| Symonds, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Yeur-Hur Lai, PhD, RN, School of Nursing, College of Medicine, National Taiwan University[NCT03883152] | 131 participants (Actual) | Observational | 2017-06-27 | Completed | |||
| An Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray on the Relief of Dry Mouth Symptoms[NCT04186806] | 40 participants (Actual) | Interventional | 2019-11-02 | Completed | |||
| Multicenter, Controlled Parallel Groups Trial to Evaluate the Efficacy, Safety and Acceptability of OGT Oromucosal Spray Versus a Saliva Substitute in the Treatment of Xerostomia in Geriatrics[NCT00350350] | 74 participants (Actual) | Observational | 2003-10-31 | Completed | |||
| Multicenter Controlled Parallel-Groups Trial to Evaluate the Efficacy, Safety and Acceptability of TGO Buccal Spray Versus a Saliva Substitute in the Treatment of Psychotropic Medicines-Induced Xerostomia[NCT00332618] | 74 participants | Observational | 2003-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 120 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.86 |
| Biotene Moisturizing Mouth Spray | 5.41 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 30 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.51 |
| Biotene Moisturizing Mouth Spray | 4.75 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 60 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.58 |
| Biotene Moisturizing Mouth Spray | 5.04 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 240 minutes post dose
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 5.14 |
| Biotene Moisturizing Mouth Spray | 5.68 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 5 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.54 |
| Biotene Moisturizing Mouth Spray | 4.62 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 15 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.394 |
| Biotene Moisturizing Mouth Spray | -2.036 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 30 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.420 |
| Biotene Moisturizing Mouth Spray | -1.900 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 5 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.203 |
| Biotene Moisturizing Mouth Spray | -1.871 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 120 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.364 |
| Biotene Moisturizing Mouth Spray | -1.657 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 240 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M Dry Mouth Moisturizing Spray | -2.322 |
| Biotene Moisturizing Mouth Spray | -1.665 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 60 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.455 |
| Biotene Moisturizing Mouth Spray | -1.833 |
Primary endpoint will be paired-difference in Visual Analog Scale (VAS) between experimental and active control product. On the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms. (NCT04186806)
Timeframe: 15 minutes post dose
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.51 |
| Biotene Moisturizing Mouth Spray | 4.6 |
3 reviews available for pilocarpine and Mouth Diseases
| Article | Year |
|---|---|
Prevention and treatment of the consequences of head and neck radiotherapy.
Topics: Anti-Bacterial Agents; Cranial Irradiation; Dental Caries; Dysgeusia; Head and Neck Neoplasms; Human | 2003 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Treatment-induced mucositis: an old problem with new remedies.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineoplastic Agents; Granulocy | 1998 |
1 trial available for pilocarpine and Mouth Diseases
| Article | Year |
|---|---|
Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Humans; Hyperhidros | 2017 |