pilocarpine has been researched along with Learning Disabilities in 8 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the mechanism underlying the development of learning deficits in patients with epilepsy, we generated a mouse model for temporal lobe epilepsy by intraperitoneally injecting mice with pilocarpine with lithium chloride, and investigated time-dependent changes in both contextual fear memory of those model mice and long-term potentiation (LTP) in hippocampal CA1 neurons 1 day, 2 weeks, and 6 weeks after the onset of status epilepticus (SE)." | 3.76 | Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model. ( Cai, GE; Ju, G; Li, ST; Lu, QC; Yang, Q; Zhang, Y, 2010) |
| ") also potentiates oxotremorine-induced tremors in mice, in a dose-dependent manner, and this effect was completely prevented by atropine." | 3.71 | Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. ( Cunha, GM; Farias, PA; Viana, GS, 2002) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soman, S | 1 |
| Anju, TR | 1 |
| Jayanarayanan, S | 1 |
| Antony, S | 1 |
| Paulose, CS | 1 |
| Yin, P | 1 |
| Liu, J | 1 |
| Li, Z | 1 |
| Wang, YY | 1 |
| Qiao, NN | 1 |
| Huang, SY | 1 |
| Li, BM | 1 |
| Sun, RP | 1 |
| Pourmotabbed, A | 1 |
| Mahmoodi, G | 1 |
| Mahmoodi, S | 1 |
| Mohammadi-Farani, A | 1 |
| Nedaei, SE | 1 |
| Pourmotabbed, T | 2 |
| Niquet, J | 1 |
| Baldwin, R | 1 |
| Norman, K | 1 |
| Suchomelova, L | 1 |
| Lumley, L | 1 |
| Wasterlain, CG | 1 |
| Masuoka, T | 1 |
| Kamei, C | 1 |
| Zhang, Y | 1 |
| Cai, GE | 1 |
| Yang, Q | 1 |
| Lu, QC | 1 |
| Li, ST | 1 |
| Ju, G | 1 |
| Mishima, K | 1 |
| Egashira, N | 1 |
| Hirosawa, N | 1 |
| Fujii, M | 1 |
| Matsumoto, Y | 1 |
| Iwasaki, K | 1 |
| Fujiwara, M | 1 |
| Cunha, GM | 1 |
| Farias, PA | 1 |
| Viana, GS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for pilocarpine and Learning Disabilities
| Article | Year |
|---|---|
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; C | 2013 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Musca | 2014 |
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, D | 2009 |
Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model.
Topics: Animals; Biophysics; Conditioning, Classical; Disease Models, Animal; Electric Stimulation; Excitato | 2010 |
Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats.
Topics: Animals; Avoidance Learning; Discrimination Learning; Dronabinol; Hallucinogens; Injections, Intrave | 2001 |
Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline.
Topics: Acetylcholinesterase; Animals; Anxiety; Avoidance Learning; Hippocampus; Learning Disabilities; Male | 2002 |