pilocarpine has been researched along with Innate Inflammatory Response in 46 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The blockage of transient receptor potential vanilloid 4 (TRPV4) inhibits inflammation and reduces hippocampal neuronal injury in a pilocarpine-induced mouse model of temporal lobe epilepsy." | 8.31 | Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. ( An, D; Chen, L; Chen, X; Du, Y; Li, K; Qi, X; Sha, S; Wang, Y; Wu, C; Xu, W, 2023) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 8.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 7.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| "Rosiglitazone reverses microglial polarization in the brains of SE mice and also affords neuroprotection against pilocarpine-induced status epilepticus without inducing significant changes in brain inflammation." | 7.91 | Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus. ( Guan, Y; Hao, Y; Li, Y; Peng, J; Wang, K; Xiang, W, 2019) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 7.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 7.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 7.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "Baicalein has multiple effects, including anti-inflammatory action." | 5.56 | Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R. ( Du, Z; Fu, P; Hu, J; Li, Z; Lv, K; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2020) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 5.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 5.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "The blockage of transient receptor potential vanilloid 4 (TRPV4) inhibits inflammation and reduces hippocampal neuronal injury in a pilocarpine-induced mouse model of temporal lobe epilepsy." | 4.31 | Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. ( An, D; Chen, L; Chen, X; Du, Y; Li, K; Qi, X; Sha, S; Wang, Y; Wu, C; Xu, W, 2023) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Levetiracetam (LEV) suppresses the upregulation of proinflammatory molecules that occurs during epileptogenesis after status epilepticus (SE)." | 4.12 | Regulation of Inflammation-Related Genes through ( Hashimoto, R; Ishihara, Y; Itoh, K; Komori, R; Kono, T; Kozawa, C; Kubo, S; Matsuo, T; Yokota-Nakatsuma, A, 2022) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 3.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| "Rosiglitazone reverses microglial polarization in the brains of SE mice and also affords neuroprotection against pilocarpine-induced status epilepticus without inducing significant changes in brain inflammation." | 3.91 | Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus. ( Guan, Y; Hao, Y; Li, Y; Peng, J; Wang, K; Xiang, W, 2019) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 3.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 3.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| "Inflammation was induced by injecting poly(I:C) (pIC 10 mg/kg, postnatal day 12-14), seizure was induced by injecting pilocarpine hydrochloride (PILO 200 mg/kg, postnatal day 15) into C57BL/6J mice, and the pIC+PILO mice were used as the iSE model (miSE)." | 3.81 | Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. ( Hirai, S; Morio, T; Nakajima, K; Okado, H, 2015) |
| " Based on this, we measured the serum levels of C-reactive protein (CRP) and cytokines during acute, silent, and chronic phases of rats submitted to the pilocarpine model of epilepsy." | 3.81 | High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? ( Cysneiros, RM; de Almeida, SS; de Brito, MV; Gouveia, TL; Naffah-Mazzacoratti, Mda G; Nejm, MB; Oliva, ML; Salu, BR; Scorza, FA; Vieira de Brito, JM; Vieira de Sousa, PV, 2015) |
| " In two-month-old survivors of the inflammatory status, seizures were evoked with pilocarpine injection." | 3.81 | Inflammation induced at different developmental stages affects differently the range of microglial reactivity and the course of seizures evoked in the adult rat. ( Janeczko, K; Kosonowska, E; Setkowicz, Z, 2015) |
| " We found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely." | 3.79 | Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ( Dingledine, R; Dudek, FE; Ganesh, T; Jiang, J; Pouliot, WA; Quan, Y, 2013) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 3.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Postnatal day 7 (P7) and P14 rat pups were injected with an exogenous provocative agent of inflammation, lipopolysaccharide (LPS), 2 h prior to limbic SE induced by either lithium-pilocarpine (LiPC) or kainic acid." | 3.74 | Inflammation exacerbates seizure-induced injury in the immature brain. ( Auvin, S; Mazarati, A; Miyamoto, J; Nakagawa, J; Sankar, R; Shin, D, 2007) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| " Since exposure to ozone also caused neuronal M2 receptors to become dependent upon cyclooxygenase the effects of viral infection are likely to be due to inflammation." | 3.69 | Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung. ( Fryer, AD; Jacoby, DB; Kahn, RM; Okanlami, OA, 1996) |
| " Granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) act outwith the haemopoeitic system and can reduce mucositis, but the best schedule, dosage and method of administration is not known or which is the best growth factor to prevent this side-effect." | 2.40 | Treatment-induced mucositis: an old problem with new remedies. ( Symonds, RP, 1998) |
| "Baicalein has multiple effects, including anti-inflammatory action." | 1.56 | Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R. ( Du, Z; Fu, P; Hu, J; Li, Z; Lv, K; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2020) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 1.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Inflammation is a hallmark of epileptogenic brain tissue." | 1.51 | Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain. ( Benifla, M; Ekstein, D; Eyal, S; Han, H; Mann, A; Polyak, B; Portnoy, E; Shmuel, M, 2019) |
| "Inflammation has detrimental influences on the developing brain including triggering the epileptogenesis." | 1.48 | Volumetric response of the adult brain to seizures depends on the developmental stage when systemic inflammation was induced. ( Janeczko, K; Kiepura, A; Kosonowska, E; Setkowicz, Z; Weglarz, W, 2018) |
| "Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures." | 1.48 | Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. ( Cavalheiro, EA; Gomes da Silva, S; Marques, MJG; Naffah-Mazzacoratti, MDG; Scorza, CA; Scorza, FA, 2018) |
| "At the age of 2 months, seizures were induced, and pilocarpine and morphological changes of astrocytes located within the hippocampal formation were assessed." | 1.46 | Inflammation in the developing rat modulates astroglial reactivity to seizures in the mature brain. ( Janeczko, K; Kosonowska, E; Setkowicz, Z, 2017) |
| "The reduction on seizure burden was associated with a limited reduction on the generation of SBDPs but was correlated with a reduction in astrocytosis, microglia activation and cell sprouting." | 1.46 | A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. ( Carlsen, J; González, MI; Lam, PM, 2017) |
| "Neuroinflammation is known to be involved in epileptogenesis with unclear mechanisms." | 1.42 | Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. ( Hung, SW; Hung, YW; Lai, MT; Lee, TS; Lin, YY; Shih, YH; Wong, LK; Wu, YC, 2015) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 1.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "Pulpitis was induced with bacterial lipolysaccharide in rat incisors dental pulp." | 1.37 | Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp. ( Borda, E; De Couto Pita, A; Orman, B; Sterin-Borda, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.52) | 18.2507 |
| 2000's | 5 (10.87) | 29.6817 |
| 2010's | 30 (65.22) | 24.3611 |
| 2020's | 8 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, H | 1 |
| Zhang, W | 2 |
| Shishmanova-Doseva, M | 2 |
| Atanasova, D | 1 |
| Ioanidu, L | 1 |
| Uzunova, Y | 2 |
| Atanasova, M | 2 |
| Peychev, L | 2 |
| Tchekalarova, J | 2 |
| An, D | 2 |
| Qi, X | 1 |
| Li, K | 2 |
| Xu, W | 2 |
| Wang, Y | 3 |
| Chen, X | 1 |
| Sha, S | 2 |
| Wu, C | 2 |
| Du, Y | 2 |
| Chen, L | 3 |
| Komori, R | 1 |
| Matsuo, T | 1 |
| Yokota-Nakatsuma, A | 1 |
| Hashimoto, R | 1 |
| Kubo, S | 1 |
| Kozawa, C | 1 |
| Kono, T | 1 |
| Ishihara, Y | 1 |
| Itoh, K | 1 |
| Peng, J | 3 |
| Wang, K | 1 |
| Xiang, W | 1 |
| Li, Y | 4 |
| Hao, Y | 1 |
| Guan, Y | 1 |
| Zhu, X | 1 |
| Yao, Y | 1 |
| Yang, J | 2 |
| Ge, Q | 1 |
| Niu, D | 1 |
| Liu, X | 1 |
| Zhang, C | 1 |
| Gan, G | 1 |
| Zhang, A | 1 |
| Yao, H | 1 |
| Hu, H | 2 |
| Zhu, T | 1 |
| Gong, L | 1 |
| Zhao, Y | 1 |
| Shao, Y | 2 |
| Li, S | 2 |
| Sun, Z | 1 |
| Ling, Y | 1 |
| Tao, Y | 1 |
| Ying, Y | 1 |
| Lan, C | 1 |
| Xie, Y | 2 |
| Jiang, P | 1 |
| Fu, P | 1 |
| Yuan, Q | 1 |
| Sun, Y | 1 |
| Wu, X | 1 |
| Du, Z | 1 |
| Li, Z | 1 |
| Yu, J | 1 |
| Lv, K | 1 |
| Hu, J | 1 |
| Yoanidu, L | 1 |
| Georgieva, K | 1 |
| Xiao, Z | 1 |
| Wu, L | 2 |
| Arafat, A | 1 |
| Yin, F | 2 |
| Luo, Q | 1 |
| Ren, Z | 1 |
| Zhu, L | 1 |
| Feng, Y | 1 |
| Li, B | 1 |
| Chen, Y | 1 |
| Setkowicz, Z | 3 |
| Kosonowska, E | 3 |
| Janeczko, K | 3 |
| Kiepura, A | 1 |
| Weglarz, W | 1 |
| Wang, X | 1 |
| Li, L | 1 |
| Kong, H | 1 |
| You, B | 1 |
| Chen, S | 1 |
| Wang, RF | 1 |
| Xue, GF | 1 |
| Hölscher, C | 1 |
| Tian, MJ | 1 |
| Feng, P | 1 |
| Zheng, JY | 1 |
| Li, DF | 1 |
| Yu, M | 1 |
| Yang, F | 2 |
| Tu, M | 1 |
| Xu, H | 1 |
| Xia, J | 1 |
| Li, CY | 1 |
| Wang, H | 1 |
| Zhang, QM | 1 |
| Han, ZM | 1 |
| Nascimento, BPP | 1 |
| Bocco, BMLC | 1 |
| Fernandes, GW | 1 |
| Fonseca, TL | 1 |
| McAninch, EA | 1 |
| Cardoso, CV | 1 |
| Bondan, EF | 1 |
| Nassif, RJ | 1 |
| Cysneiros, RM | 2 |
| Bianco, AC | 1 |
| Ribeiro, MO | 1 |
| Han, K | 1 |
| Wang, QY | 1 |
| Wang, CX | 1 |
| Luan, SY | 1 |
| Tian, WP | 1 |
| Zhang, RY | 1 |
| Ali, AE | 1 |
| Mahdy, HM | 1 |
| Elsherbiny, DM | 1 |
| Azab, SS | 1 |
| Jia, R | 1 |
| Jia, N | 1 |
| Liu, Z | 2 |
| Li, R | 2 |
| Jiang, Y | 1 |
| Zhao, J | 2 |
| Wang, L | 1 |
| Zhang, S | 1 |
| Zhang, Z | 1 |
| Zhang, H | 1 |
| Wu, S | 1 |
| Gao, F | 1 |
| Jiang, W | 1 |
| Wang, Z | 1 |
| Zhou, L | 1 |
| Zhu, Y | 1 |
| Chen, A | 1 |
| Han, H | 1 |
| Eyal, S | 1 |
| Portnoy, E | 1 |
| Mann, A | 1 |
| Shmuel, M | 1 |
| Benifla, M | 1 |
| Ekstein, D | 1 |
| Polyak, B | 1 |
| Hung, YW | 1 |
| Hung, SW | 1 |
| Wu, YC | 1 |
| Wong, LK | 1 |
| Lai, MT | 1 |
| Shih, YH | 1 |
| Lee, TS | 1 |
| Lin, YY | 1 |
| Patel, N | 1 |
| Duffy, BA | 1 |
| Badar, A | 1 |
| Lythgoe, MF | 1 |
| Årstad, E | 1 |
| Gouveia, TL | 1 |
| Vieira de Sousa, PV | 1 |
| de Almeida, SS | 1 |
| Nejm, MB | 1 |
| Vieira de Brito, JM | 1 |
| de Brito, MV | 1 |
| Salu, BR | 1 |
| Oliva, ML | 1 |
| Scorza, FA | 2 |
| Naffah-Mazzacoratti, Mda G | 1 |
| Nakajima, K | 1 |
| Hirai, S | 1 |
| Morio, T | 1 |
| Okado, H | 1 |
| Long, X | 1 |
| Chen, M | 1 |
| Cai, J | 1 |
| Song, B | 1 |
| González-Reyes, S | 1 |
| Santillán-Cigales, JJ | 1 |
| Jiménez-Osorio, AS | 1 |
| Pedraza-Chaverri, J | 1 |
| Guevara-Guzmán, R | 1 |
| Scorza, CA | 1 |
| Marques, MJG | 1 |
| Gomes da Silva, S | 1 |
| Naffah-Mazzacoratti, MDG | 1 |
| Cavalheiro, EA | 1 |
| Lam, PM | 1 |
| Carlsen, J | 1 |
| González, MI | 1 |
| Tao, H | 1 |
| Liu, T | 1 |
| Cai, Y | 1 |
| Zhou, X | 1 |
| Xing, H | 1 |
| Yin, M | 1 |
| Zhong, W | 1 |
| Zhao, B | 1 |
| Zhou, H | 1 |
| Cui, L | 1 |
| Navarro Mora, G | 1 |
| Bramanti, P | 1 |
| Osculati, F | 1 |
| Chakir, A | 1 |
| Nicolato, E | 1 |
| Marzola, P | 1 |
| Sbarbati, A | 1 |
| Fabene, PF | 1 |
| Kanda, T | 1 |
| Tsuji, K | 1 |
| Hiyama, K | 1 |
| Tsuka, T | 1 |
| Minami, S | 1 |
| Hikasa, Y | 1 |
| Furukawa, T | 1 |
| Okamoto, Y | 1 |
| Auvin, S | 3 |
| Mazarati, A | 3 |
| Shin, D | 3 |
| Sankar, R | 3 |
| Sterin-Borda, L | 1 |
| Orman, B | 1 |
| De Couto Pita, A | 1 |
| Borda, E | 1 |
| Al-Shorbagy, MY | 1 |
| El Sayeh, BM | 1 |
| Abdallah, DM | 1 |
| Jiang, J | 1 |
| Quan, Y | 1 |
| Ganesh, T | 1 |
| Pouliot, WA | 1 |
| Dudek, FE | 1 |
| Dingledine, R | 1 |
| Voutsinos-Porche, B | 1 |
| Koning, E | 1 |
| Kaplan, H | 1 |
| Ferrandon, A | 1 |
| Guenounou, M | 1 |
| Nehlig, A | 1 |
| Motte, J | 1 |
| Nakagawa, J | 1 |
| Miyamoto, J | 1 |
| Sun, H | 1 |
| Huang, Y | 1 |
| Yu, X | 1 |
| Deng, Y | 1 |
| Zhao, G | 1 |
| Elbon, CL | 1 |
| Jacoby, DB | 2 |
| Fryer, AD | 2 |
| Kahn, RM | 1 |
| Okanlami, OA | 1 |
| Symonds, RP | 1 |
1 review available for pilocarpine and Innate Inflammatory Response
| Article | Year |
|---|---|
Treatment-induced mucositis: an old problem with new remedies.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineoplastic Agents; Granulocy | 1998 |
45 other studies available for pilocarpine and Innate Inflammatory Response
| Article | Year |
|---|---|
The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/
Topics: Animals; Apoptosis; beta Catenin; Computational Biology; Disease Models, Animal; Down-Regulation; Ep | 2022 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation | 2022 |
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Antineoplastic Agents; HMGB1 Protein; Inflammation; Mice; NF-kappa B; NF-KappaB Inhibitor a | 2023 |
Regulation of Inflammation-Related Genes through
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Levetiracetam; Mice; Piloc | 2022 |
Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.
Topics: Animals; B7-2 Antigen; Brain Chemistry; Cell Polarity; Convulsants; Cytokines; Inflammation; Male; M | 2019 |
Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice.
Topics: Aggression; Animals; Cell Proliferation; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; | 2020 |
Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy.
Topics: Animals; Behavior, Animal; Cognition; Cytokines; Disease Models, Animal; Epilepsy; Hippocampus; Infl | 2020 |
Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R.
Topics: Animals; Cell Proliferation; Epilepsy; Flavanones; Hippocampus; Inflammation; Male; Microglia; Piloc | 2020 |
Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation.
Topics: Animals; Anticonvulsants; Biomarkers; Hippocampus; Inflammation; Interleukin-1beta; Lacosamide; Male | 2021 |
The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Epilepsy, Tempor | 2017 |
Involvement of microRNA-146a in the Inflammatory Response of S tatus Epilepticus Rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Cytokines; Disease Models, Animal; Gene Expression Regulati | 2017 |
Inflammation in the developing rat modulates astroglial reactivity to seizures in the mature brain.
Topics: Animals; Astrocytes; Brain; Glial Fibrillary Acidic Protein; Inflammation; Lipopolysaccharides; Male | 2017 |
Volumetric response of the adult brain to seizures depends on the developmental stage when systemic inflammation was induced.
Topics: Animals; Brain; Inflammation; Lipopolysaccharides; Magnetic Resonance Imaging; Male; Pilocarpine; Ra | 2018 |
Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus.
Topics: Animals; Antagomirs; Disease Models, Animal; Hippocampus; Inflammation; Lithium Compounds; Male; Mic | 2018 |
Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Blood Glucose; Convulsants; Cytokines | 2018 |
Notch Signaling Regulates Microglial Activation and Inflammatory Reactions in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Inflammation; Inflammation Mediators; Male; Microglia; Pilocarpine | 2018 |
Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice.
Topics: Acute Disease; Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Coumarins; Cytokines; Enzyme Act | 2018 |
Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Topics: Amygdala; Animals; Apoptosis; Astrocytes; Cell Death; Cell Nucleus; Gene Expression; Hippocampus; In | 2018 |
Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α.
Topics: Animals; Anti-Inflammatory Agents; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Epileps | 2018 |
Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries.
Topics: Animals; Apoptosis; Hippocampus; Inflammation; Lithium Chloride; Male; Memory Disorders; Oxidative S | 2018 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; | 2019 |
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Inflammasomes; Inflammation; Leucine; Male; Mice; Mice | 2019 |
Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.
Topics: Animals; Boron Compounds; Disease Models, Animal; Drug Delivery Systems; Epilepsy, Temporal Lobe; Fl | 2019 |
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Epoxide Hydrolases; Hippocampus; Inflammat | 2015 |
Inflammation induced at different developmental stages affects differently the range of microglial reactivity and the course of seizures evoked in the adult rat.
Topics: Age Factors; Animals; Cytokines; Hippocampus; Inflammation; Inflammation Mediators; Male; Microglia; | 2015 |
Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates.
Topics: Animals; Antibodies, Monoclonal; Brain; Contrast Media; Ferric Compounds; Image Processing, Computer | 2015 |
High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?
Topics: Animals; Behavior, Animal; Biomarkers; C-Reactive Protein; Convulsants; Cytokines; Epilepsy; Fatty A | 2015 |
Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus.
Topics: Animals; Anticonvulsants; Apoptosis; Benzodiazepines; Convulsants; Exploratory Behavior; GABA Agonis | 2015 |
Hippocampal YKL-40 expression in rats after status epilepticus.
Topics: Animals; Antigens, Nuclear; Chitinase-3-Like Protein 1; Cytoplasm; Disease Models, Animal; Fluoresce | 2016 |
Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Fluorometry; Glycyrrhizic A | 2016 |
Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis.
Topics: Animals; Cerebral Cortex; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; I | 2018 |
A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Calpain; Cerebral Cortex; Dipeptides; Disease Models, Animal; Dose-Respons | 2017 |
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lo | 2017 |
Does pilocarpine-induced epilepsy in adult rats require status epilepticus?
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Inflammatio | 2009 |
Mydriasis associated with local dysfunction of parasympathetic nerves in two dogs.
Topics: Animals; Anti-Inflammatory Agents; Autonomic Nervous System Diseases; Dog Diseases; Dogs; Female; In | 2010 |
Inflammation enhances epileptogenesis in the developing rat brain.
Topics: Age Factors; Aging; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Gliosis; Inflamma | 2010 |
Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp.
Topics: Analysis of Variance; Animals; Dental Pulp; Disease Models, Animal; Drug Inverse Agonism; Inflammati | 2011 |
Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; CA3 Region, Hippocampal; Dexamethasone; Dinoprostone; Diseas | 2012 |
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Disease Models, Animal; Hippocampus; Humans; I | 2013 |
Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Interleuki | 2004 |
Inflammation exacerbates seizure-induced injury in the immature brain.
Topics: Acute Disease; Animals; Animals, Newborn; Body Temperature; Brain; Cell Count; Disease Models, Anima | 2007 |
Inflammation modifies status epilepticus-induced hippocampal injury during development.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Hippocampus; Inflammation; Kainic Acid; Li | 2007 |
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.
Topics: Animals; Benzamides; Blotting, Western; Brain Injuries; CD40 Antigens; Central Nervous System Diseas | 2008 |
Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs.
Topics: Animals; Bronchoconstriction; Chemotaxis, Leukocyte; Female; Gallamine Triethiodide; Guinea Pigs; Hy | 1995 |
Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung.
Topics: Animals; Antibodies, Viral; Benzoquinones; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Stim | 1996 |