pilocarpine has been researched along with Graft-Versus-Host Disease in 7 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, placebo-controlled study was conducted to evaluate the effect of orally administered pilocarpine on unstimulated whole-saliva flow and composition in 28 patients with chronic graft-versus-host disease (cGVHD)." | 7.74 | Effect of pilocarpine hydrochloride on unstimulated whole saliva flow rate and composition in patients with chronic graft-versus-host disease (cGVHD). ( Agha-Hosseini, F; Ghavamzadeh, A; Ghavamzadeh, L; Mirzaii-Dizgah, I; Tohidast-Acrad, Z, 2007) |
| " Oral pilocarpine (Salagen(R)), 30 mg/day, can ameliorate cGVHD-induced xerostomia and improve the flow rate from the major salivary glands." | 7.71 | The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease. ( Nagler, A; Nagler, RM, 2001) |
| "As pilocarpine hydrochloride has been shown to relieve xerostomia in other disease categories, we administered pilocarpine hydrochloride 30 mg/day to six cGVHD patients and measured their whole saliva, parotid and submandibular-sublingual flow rates in both resting and stimulated conditions." | 5.30 | Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. ( Nagler, A; Nagler, RM, 1999) |
| "A double-blind, placebo-controlled study was conducted to evaluate the effect of orally administered pilocarpine on unstimulated whole-saliva flow and composition in 28 patients with chronic graft-versus-host disease (cGVHD)." | 3.74 | Effect of pilocarpine hydrochloride on unstimulated whole saliva flow rate and composition in patients with chronic graft-versus-host disease (cGVHD). ( Agha-Hosseini, F; Ghavamzadeh, A; Ghavamzadeh, L; Mirzaii-Dizgah, I; Tohidast-Acrad, Z, 2007) |
| " Oral pilocarpine (Salagen(R)), 30 mg/day, can ameliorate cGVHD-induced xerostomia and improve the flow rate from the major salivary glands." | 3.71 | The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease. ( Nagler, A; Nagler, RM, 2001) |
| "Oral pilocarpine was able to reduce and normalize the elevated levels of Na, Mg, TP, Alb, EGF, IgG, and IgA salivary concentrations at both resting and stimulated conditions." | 1.32 | Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged study. ( Nagler, A; Nagler, RM, 2003) |
| "As pilocarpine hydrochloride has been shown to relieve xerostomia in other disease categories, we administered pilocarpine hydrochloride 30 mg/day to six cGVHD patients and measured their whole saliva, parotid and submandibular-sublingual flow rates in both resting and stimulated conditions." | 1.30 | Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. ( Nagler, A; Nagler, RM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagler, RM | 3 |
| Nagler, A | 3 |
| Agha-Hosseini, F | 1 |
| Mirzaii-Dizgah, I | 1 |
| Ghavamzadeh, L | 1 |
| Ghavamzadeh, A | 1 |
| Tohidast-Acrad, Z | 1 |
| Singhal, S | 2 |
| Mehta, J | 2 |
| Rattenbury, H | 2 |
| Treleaven, J | 2 |
| Powles, R | 2 |
| Nagler, R | 1 |
1 review available for pilocarpine and Graft-Versus-Host Disease
| Article | Year |
|---|---|
[New therapeutic strategies for xerostomia in chronic graft versus host disease patients].
Topics: Animals; Chronic Disease; Cytokines; Graft vs Host Disease; Humans; Muscarinic Agonists; Pilocarpine | 2000 |
2 trials available for pilocarpine and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Oral pilocarpine hydrochloride for the treatment of refractory xerostomia associated with chronic graft-versus-host disease.
Topics: Administration, Oral; Graft vs Host Disease; Humans; Mouth Mucosa; Pilocarpine; Saliva; Xerostomia | 1995 |
Pilocarpine hydrochloride for symptomatic relief of xerostomia due to chronic graft-versus-host disease or total-body irradiation after bone-marrow transplantation for hematologic malignancies.
Topics: Bone Marrow Transplantation; Chronic Disease; Graft vs Host Disease; Hematologic Neoplasms; Humans; | 1997 |
4 other studies available for pilocarpine and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged study.
Topics: Adolescent; Adult; Albumins; Cations; Chronic Disease; Epidermal Growth Factor; Female; Follow-Up St | 2003 |
Effect of pilocarpine hydrochloride on unstimulated whole saliva flow rate and composition in patients with chronic graft-versus-host disease (cGVHD).
Topics: Administration, Oral; Adult; Calcium; Double-Blind Method; Female; Graft vs Host Disease; Humans; Im | 2007 |
Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Chronic Disease; Female; Graft vs Host Disease; Huma | 1999 |
The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease.
Topics: Administration, Oral; Albumins; Calcium; Chronic Disease; Epidermal Growth Factor; Graft vs Host Dis | 2001 |