pilocarpine has been researched along with Genetic Predisposition in 13 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 7.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " Using C57BL/6J × A/J chromosome substitution strains (CSS), we previously identified a locus on mouse chromosome 10 (Ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic seizures and status epilepticus (status), followed by hippocampal cell loss and delayed-onset chronic spontaneous limbic seizures." | 3.77 | Mapping a mouse limbic seizure susceptibility locus on chromosome 10. ( Gildersleeve, SS; Palmer, AA; Phillips, AG; Rabinowitz, D; Winawer, MR, 2011) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 3.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| "In rodents, the cholinomimetic convulsant pilocarpine is widely used to induce status epilepticus (SE), followed by hippocampal damage and spontaneous recurrent seizures, resembling temporal lobe epilepsy." | 3.75 | Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice. ( Gröticke, I; Hoffmann, K; Löscher, W; Müller, CJ; Schughart, K, 2009) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " QTLs for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not been reported, and CSS have not previously been used to localize seizure susceptibility genes." | 3.74 | Use of chromosome substitution strains to identify seizure susceptibility loci in mice. ( Guell, IP; Kuperman, R; Niethammer, M; Palmer, AA; Ponder, CA; Rabinowitz, D; Sherman, S; Winawer, MR, 2007) |
| "We used pilocarpine-induced seizures in mice to determine the impact of genetic background on the vulnerability of hippocampal neurons and associated changes of behavioral performance." | 3.72 | The impact of genetic background on neurodegeneration and behavior in seizured mice. ( Lipp, HP; Madani, R; Mohajeri, MH; Nitsch, RM; Saini, K; Wolfer, DP, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, X | 1 |
| Yang, F | 1 |
| Li, A | 1 |
| Zhao, D | 1 |
| Ma, N | 1 |
| Chen, L | 1 |
| Lin, S | 1 |
| Lin, Y | 1 |
| Wang, L | 1 |
| Yan, X | 1 |
| Zheng, M | 1 |
| Lee, TH | 1 |
| Zhou, XZ | 1 |
| Lu, KP | 1 |
| Liu, H | 1 |
| Winawer, MR | 3 |
| Klassen, TL | 1 |
| Teed, S | 1 |
| Shipman, M | 1 |
| Leung, EH | 1 |
| Palmer, AA | 3 |
| Kim, JY | 1 |
| Ko, AR | 1 |
| Hyun, HW | 1 |
| Min, SJ | 1 |
| Kim, JE | 1 |
| Hanaya, R | 1 |
| Koning, E | 1 |
| Ferrandon, A | 1 |
| Nehlig, A | 1 |
| Becker, AJ | 2 |
| Pitsch, J | 2 |
| Sochivko, D | 1 |
| Opitz, T | 1 |
| Staniek, M | 1 |
| Chen, CC | 1 |
| Campbell, KP | 1 |
| Schoch, S | 2 |
| Yaari, Y | 1 |
| Beck, H | 1 |
| Young, NA | 1 |
| Vuong, J | 1 |
| Ozen, LJ | 1 |
| Flynn, C | 1 |
| Teskey, GC | 1 |
| Müller, CJ | 1 |
| Gröticke, I | 1 |
| Hoffmann, K | 1 |
| Schughart, K | 1 |
| Löscher, W | 1 |
| Gildersleeve, SS | 1 |
| Phillips, AG | 1 |
| Rabinowitz, D | 2 |
| Mohajeri, MH | 1 |
| Madani, R | 1 |
| Saini, K | 1 |
| Lipp, HP | 1 |
| Nitsch, RM | 1 |
| Wolfer, DP | 1 |
| Kuperman, R | 1 |
| Niethammer, M | 1 |
| Sherman, S | 1 |
| Guell, IP | 1 |
| Ponder, CA | 1 |
| Gueler, N | 1 |
| Flor, PJ | 1 |
| van der Putten, H | 1 |
| Pacheco Otalora, LF | 1 |
| Hernandez, EF | 1 |
| Arshadmansab, MF | 1 |
| Francisco, S | 1 |
| Willis, M | 1 |
| Ermolinsky, B | 1 |
| Zarei, M | 1 |
| Knaus, HG | 1 |
| Garrido-Sanabria, ER | 1 |
| Mejías-Aponte, CA | 1 |
| Jiménez-Rivera, CA | 1 |
| Segarra, AC | 1 |
13 other studies available for pilocarpine and Genetic Predisposition
| Article | Year |
|---|---|
The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Epilepsy; Genetic Predisposition | 2021 |
A locus on mouse Ch10 influences susceptibility to limbic seizure severity: fine mapping and in silico candidate gene analysis.
Topics: Animals; Chromosome Mapping; Chromosomes, Human, Pair 12; Chromosomes, Mammalian; Computational Biol | 2014 |
PDI regulates seizure activity via NMDA receptor redox in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Ep | 2017 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.
Topics: Animals; Calcium Channels, T-Type; Calcium Signaling; Channelopathies; Disease Models, Animal; Epile | 2008 |
Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Progression; Dose-Response Re | 2009 |
Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2009 |
Mapping a mouse limbic seizure susceptibility locus on chromosome 10.
Topics: Animals; Chromosome Mapping; Convulsants; Genetic Predisposition to Disease; Genotype; Limbic System | 2011 |
The impact of genetic background on neurodegeneration and behavior in seizured mice.
Topics: Animals; Cell Death; Convulsants; Crosses, Genetic; Exploratory Behavior; Genetic Predisposition to | 2004 |
Use of chromosome substitution strains to identify seizure susceptibility loci in mice.
Topics: Animals; Chromosomes; Genetic Predisposition to Disease; Genetic Techniques; Male; Mice; Mice, Inbre | 2007 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Ge | 2007 |
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chronic Disease; Convulsants; Disease Models, Animal; Down- | 2008 |
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; E | 2002 |