pilocarpine has been researched along with Experimental Radiation Injuries in 21 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was performed to assess the effects of pilocarpine hydrochloride ((3S,4R)-3-ethyl-dihydro-4-[(1-methyl-1H-imidazole-5-yl)methyl]-2(3H)-furanone monohydrochloride, CAS 54-71-7) and cevimeline ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, CAS 153504-70-2), muscarinic receptor agonists, on salivary secretion from the submandibular/sublingual (SM/SL) glands in normal rats and in rats with xerostomia induced by X-ray (15 Gy) irradiation." | 7.72 | Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. ( Asari, T; Kojima, M; Kusama, H; Maruyama, K; Omori, Y; Shibata, N, 2003) |
| " The analysis was performed in three conditions: naïve, during latent phase after pilocarpine-induced status epilepticus and after 21 days of transauricular electric shocks." | 3.88 | Profiles of gene expression in the hippocampal formation of rats with experimentally-induced brain dysplasia. ( Gzielo, K; Janeczko, K; Kielbinski, M; Setkowicz, Z, 2018) |
| " Using rats, we examined the muscarinic receptor subtype mediating pilocarpine-induced parotid salivary secretion and the contributions of ion transporter systems (effluxes of K+ and Cl(-)) and aquaporin-5 (AQP5) translocation to this response in parotid glands in irradiated-induced xerostomia." | 3.75 | Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats. ( Asari, T; Kusama, H; Maruyama, K, 2009) |
| "The present study was performed to assess the effects of pilocarpine hydrochloride ((3S,4R)-3-ethyl-dihydro-4-[(1-methyl-1H-imidazole-5-yl)methyl]-2(3H)-furanone monohydrochloride, CAS 54-71-7) and cevimeline ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, CAS 153504-70-2), muscarinic receptor agonists, on salivary secretion from the submandibular/sublingual (SM/SL) glands in normal rats and in rats with xerostomia induced by X-ray (15 Gy) irradiation." | 3.72 | Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. ( Asari, T; Kojima, M; Kusama, H; Maruyama, K; Omori, Y; Shibata, N, 2003) |
| "Pilocarpine pre-treated rats, protection of parotid gland function was seen in the early-intermediate phase (0-120 days) after 15 Gy and in the late phase (>120 days) after 10 and 15 Gy." | 1.35 | Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment. ( Burlage, FR; Coppes, RP; Faber, H; Kampinga, HH; Langendijk, JA; Roesink, JM; Vissink, A, 2008) |
| "Pretreatment with lidocaine and amifostine-but not with pilocarpine-induced lower up-regulation of TN-C expression 72 h after radiation." | 1.34 | Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model. ( Beutel, J; Geerling, G; Hakim, SG; Kosmehl, H; Rades, D; Schroder, C; Sieg, P; von Hof, K; Wedel, T, 2007) |
| "Pilocarpine (4 mg/kg) was administered intraperitoneally, 1 hour prior to irradiation." | 1.30 | Preservation of the rat parotid gland function after radiation by prophylactic pilocarpine treatment: radiation dose dependency and compensatory mechanisms. ( Battermann, JJ; Coppes, RP; Kampinga, HH; Konings, AW; Roesink, JM; Terhaard, CH, 1999) |
| "Pilocarpine pretreatment was protective against irradiation, displaying much less damage after irradiation of the same dosage, and with complete recovery after 4 weeks." | 1.28 | The effect of pilocarpine and atropine administration on radiation-induced injury of rat submandibular glands. ( Kim, CW; Kim, JY; Kim, KH; Sung, MW, 1991) |
| "Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser." | 1.27 | Pharmacological testing in the laser-induced monkey glaucoma model. ( Howard-Williams, JR; Lee, PY; Podos, SM; Rose, AD; Severin, CH; Siegel, MJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kielbinski, M | 1 |
| Setkowicz, Z | 2 |
| Gzielo, K | 1 |
| Janeczko, K | 2 |
| Kymionis, GD | 1 |
| Portaliou, DM | 1 |
| Burlage, FR | 2 |
| Faber, H | 2 |
| Kampinga, HH | 3 |
| Langendijk, JA | 2 |
| Vissink, A | 3 |
| Coppes, RP | 4 |
| Asari, T | 2 |
| Maruyama, K | 2 |
| Kusama, H | 2 |
| Omori, Y | 1 |
| Kojima, M | 1 |
| Shibata, N | 1 |
| DANYSZ, A | 2 |
| PRONIEWSKI, H | 1 |
| WISNIEWSKI, K | 1 |
| ZACZEK, T | 1 |
| POLOCKI, B | 2 |
| SETAELAE, K | 1 |
| LINDROOS, B | 1 |
| KUIKKA, AO | 1 |
| Janicka, D | 1 |
| Kowalczyk, A | 1 |
| Turlej, A | 1 |
| Beutel, J | 1 |
| Schroder, C | 1 |
| von Hof, K | 1 |
| Rades, D | 1 |
| Kosmehl, H | 1 |
| Wedel, T | 1 |
| Sieg, P | 1 |
| Geerling, G | 1 |
| Hakim, SG | 1 |
| Roesink, JM | 2 |
| Ahlner, BH | 1 |
| Hagelqvist, E | 1 |
| Lind, MG | 1 |
| Johns, H | 1 |
| Morris, WJ | 1 |
| Joiner, MC | 1 |
| Nagler, RM | 1 |
| Laufer, D | 1 |
| Konings, AW | 2 |
| Terhaard, CH | 1 |
| Battermann, JJ | 1 |
| Zeilstra, LJ | 1 |
| Dreiling, DA | 1 |
| Noronha, M | 1 |
| Nacchiero, M | 1 |
| Pieroni, P | 1 |
| Wolfson, P | 1 |
| Kim, KH | 1 |
| Kim, JY | 1 |
| Sung, MW | 1 |
| Kim, CW | 1 |
| Lee, PY | 1 |
| Podos, SM | 1 |
| Howard-Williams, JR | 1 |
| Severin, CH | 1 |
| Rose, AD | 1 |
| Siegel, MJ | 1 |
| Lauber, JK | 1 |
| McLaughlin, MA | 1 |
| Chiou, GC | 1 |
| Hockwin, O | 1 |
| Szaykowski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of the Oral Administration of an Association of Forskolin With Rutin and Vitamins B on Intraocular Pressure in Patients Affected by Primary Open Angle Glaucoma and Treated With Either Beta-blockers or Prostaglandin Eye Drops[NCT00863811] | 0 participants (Actual) | Observational | 2009-04-30 | Withdrawn (stopped due to loss of interest before enrolment started) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 other studies available for pilocarpine and Experimental Radiation Injuries
| Article | Year |
|---|---|
Profiles of gene expression in the hippocampal formation of rats with experimentally-induced brain dysplasia.
Topics: Animals; Electroshock; Hippocampus; Male; Malformations of Cortical Development; Microarray Analysis | 2018 |
Use of isoptocarpine in corneal collagen crosslinking.
Topics: Animals; Collagen; Cornea; Debridement; Epithelium, Corneal; Lens, Crystalline; Miotics; Muscarinic | 2008 |
Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands.
Topics: Animals; Cell Proliferation; Immunohistochemistry; Male; Muscarinic Agonists; Parotid Gland; Pilocar | 2009 |
Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats.
Topics: Animals; Aquaporin 5; Calcium; Male; Muscarinic Agonists; Muscarinic Antagonists; Parotid Gland; Pil | 2009 |
Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.
Topics: Animals; Antipsychotic Agents; Body Temperature; Cardiovascular System; Central Nervous System; Chlo | 2003 |
REACTIVITY TO VEGETATIVE DRUGS IN THE ACUTE RADIATION SICKNESS.
Topics: Acetylcholine; Atropine; Cats; Dogs; Epinephrine; Guinea Pigs; Iproniazid; Mice; Neostigmine; Nicoti | 1963 |
[ON THE REMOVAL OF INCORPORATED STRONTIUM ISOTOPES IN EXPERIMENTAL ANIMALS. THEORETICAL PRINCIPLES FOR THE DECORPORATION TECHNIC WITH SOME EXPERIMENTAL RESULTS].
Topics: Animals; Bone and Bones; Cats; Mice; Pharmacology; Pilocarpine; Radiation Injuries; Radiation Injuri | 1964 |
Congenital brain dysplasias of different genesis can differently affect susceptibility to pilocarpine- or kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Brain Diseases; Convulsants; Dose-Response Relationship, Drug; Electroenc | 2005 |
Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model.
Topics: Actins; Amifostine; Animals; Dry Eye Syndromes; Female; Immunoenzyme Techniques; Lacrimal Apparatus; | 2007 |
Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment.
Topics: Animals; Male; Muscarinic Antagonists; Parotid Gland; Pilocarpine; Radiation Injuries, Experimental; | 2008 |
Influence on rabbit submandibular gland injury by stimulation or inhibition of gland function during irradiation. Histology and morphometry after 15 gray.
Topics: Animals; Biperiden; Female; Male; Organ Size; Pilocarpine; Rabbits; Radiation Dosage; Radiation Inju | 1994 |
Radiation response of murine eccrine sweat glands.
Topics: Animals; Dose-Response Relationship, Radiation; Eccrine Glands; Foot; Hindlimb; Hypohidrosis; Male; | 1995 |
Protection against irradiation-induced damage to salivary glands by adrenergic agonist administration.
Topics: Adrenergic Agonists; Ancitabine; Animals; Cell Degranulation; Cytoplasmic Granules; Male; Parotid Gl | 1998 |
Preservation of the rat parotid gland function after radiation by prophylactic pilocarpine treatment: radiation dose dependency and compensatory mechanisms.
Topics: Animals; Injections, Intraperitoneal; Male; Muscarinic Agonists; Parotid Gland; Pilocarpine; Radiati | 1999 |
Radiation induced cell loss in rat submandibular gland and its relation to gland function.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Cell Count; Cell Nucleus; Cytoplasmic Granules; Mal | 2000 |
The parotid and the pancreas. VI. Clinical and physiologic associations between the pancreas and parotid glands.
Topics: Amylases; Animals; Bethanechol Compounds; Bicarbonates; Dogs; Hydrogen-Ion Concentration; Infusions, | 1978 |
The effect of pilocarpine and atropine administration on radiation-induced injury of rat submandibular glands.
Topics: Analysis of Variance; Animals; Atropine; Cobalt Radioisotopes; Cytoplasmic Granules; Injections, Int | 1991 |
Pharmacological testing in the laser-induced monkey glaucoma model.
Topics: Administration, Topical; Animals; Colforsin; Dinoprost; Diterpenes; Epinephrine; Glaucoma; Intraocul | 1985 |
Timolol and pilocarpine are hypotensive in light-induced avian glaucoma.
Topics: Animals; Aqueous Humor; Chickens; Eye; Glaucoma; Injections, Intravenous; Intraocular Pressure; Ligh | 1985 |
[Clinical significance of the production of experimental cataract by means of addition of subliminal injuries].
Topics: Animals; Cataract; Eye Injuries; Guinea Pigs; Humans; Lens, Crystalline; Naphthalenes; Pilocarpine; | 1969 |
[The reaction of rat intestine to parasympathicotonic agents during the course of radiation sickness].
Topics: Acetylcholine; Acetylcholinesterase; Adrenal Glands; Animals; Brain; Catecholamines; Colorimetry; In | 1966 |