pilocarpine has been researched along with Epilepsy, Tonic-Clonic in 5 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thresholds for producing seizures in brain-derived neurotrophic factor wild-type and brain-derived neurotrophic factor heterozygous mice were compared in several seizure models, including thresholds for electrically-induced clonic, tonic-clonic and 6 Hz limbic seizures, as well as seizures induced chemically by kainate, pilocarpine and pentylenetetrazol." | 3.73 | The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. ( Barton, ME; Shannon, HE, 2005) |
| "Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior." | 1.38 | Social behavior impairment in offspring exposed to maternal seizures in utero. ( Amado, D; Cysneiros, RM; Novaes, GF; Scorza, FA, 2012) |
| "Transition into limbic seizures and recurrent seizures were delayed in both age groups and threshold intensities for limbic ADs were at some intervals higher in SE than in control animals." | 1.35 | Changes of cortical epileptic afterdischarges after status epilepticus in immature rats. ( Kubová, H; Mares, P; Tsenov, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Novaes, GF | 1 |
| Amado, D | 1 |
| Scorza, FA | 1 |
| Cysneiros, RM | 1 |
| Barton, ME | 1 |
| Shannon, HE | 1 |
| Tsenov, G | 1 |
| Kubová, H | 1 |
| Mares, P | 1 |
| Kofman, O | 1 |
| Sherman, WR | 1 |
| Katz, V | 1 |
| Belmaker, RH | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
5 other studies available for pilocarpine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Social behavior impairment in offspring exposed to maternal seizures in utero.
Topics: Animals; Anxiety; Convulsants; Epilepsy, Tonic-Clonic; Female; Male; Pilocarpine; Pregnancy; Pregnan | 2012 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; El | 2005 |
Changes of cortical epileptic afterdischarges after status epilepticus in immature rats.
Topics: Aging; Animals; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy | 2008 |
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Int | 1993 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |