pilocarpine has been researched along with Epilepsy, Temporal Lobe in 502 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 8.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 8.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 8.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " The anxiety induced by pilocarpine was also significantly (P < 0." | 8.12 | Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. ( Bum, EN; Kouemou Emegam, N; Neteydji, S; Pale, S; Taiwe, GS, 2022) |
| " This study aimed to analyze the changes in gene expression of mGluR subtypes (1-5, 7, 8) in various rat brain regions in the latent and chronic phases of a lithium-pilocarpine model of epilepsy." | 8.12 | Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy. ( Dyomina, AV; Kovalenko, AA; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 8.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test." | 8.02 | Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test. ( Bocca Nejm, M; Cysneiros, RM; Finsterer, J; Guimarães-Marques, MJ; Scorza, CA; Scorza, FA; Victorino, DB, 2021) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 7.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 7.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 7.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 7.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| "Subconvulsant doses of pilocarpine promote long-lasting alterations on neural circuitry, reflected by an increased theta activity in the hippocampus and an anxiety-like profile of rats evaluated 1 month after the treatment which is independent of seizure occurrence and is not related to changes in glutamate uptake or hippocampal damage." | 7.79 | Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? ( Carobrez, AP; De Lima, TC; Duarte, FS; Duzzioni, M; Ern, AL; Gavioli, EC; Hoeller, AA; Lemos, T; Piermartiri, TC; Silva, NM; Tasca, CI, 2013) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 7.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 7.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " A significant loss of total dorsal subicular neurons, particularly calbindin, parvalbumin (PV) and immunopositive interneurons, was found at 2 months after pilocarpine-induced status epilepticus (SE)." | 7.76 | Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus. ( Bragin, A; Engel, J; He, DF; Ma, DL; Tang, FR; Tang, YC, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 7.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 7.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 7.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 7.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 7.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " Furthermore, we examined whether the MRP2 protein is overexpressed after experimentally induced seizures in rats, using the pilocarpine model of temporal lobe epilepsy." | 7.73 | Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. ( Gastens, AM; Hoffmann, K; Löscher, W; Volk, HA, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 7.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 7.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 7.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 7.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 7.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 7.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 7.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 5.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 5.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 5.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 5.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "Fundamental work on the mechanisms leading to focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial status epilepticus (SE) is induced by kainic acid or pilocarpine." | 5.12 | The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches. ( Avoli, M; Biagini, G; de Curtis, M; Gnatkovsky, V; Lévesque, M; Pitsch, J; Wang, S, 2021) |
| "The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs)." | 4.85 | The pilocarpine model of epilepsy: what have we learned? ( Arida, RM; Calderazzo, L; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Scerni, DA; Scorza, FA, 2009) |
| "Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model." | 4.84 | The pilocarpine model of temporal lobe epilepsy. ( Avoli, M; Biagini, G; Curia, G; Jones, RS; Longo, D, 2008) |
| " Among post-status epilepticus models, induction of systemic kainic acid or pilocarpine-induced epilepsy is less labor-intensive than electrical-stimulation models and these models mirror the clinicopathologic features of MTLE more closely than do kindling, tetanus toxin, hyperthermia, post-traumatic, and perinatal hypoxia/ischemia models." | 4.84 | Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. ( Jordan, WH; Miller, MA; Reams, RY; Sharma, AK; Snyder, PW; Thacker, HL, 2007) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 4.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 4.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| " Here, tau expression and phosphorylation at three canonical loci known to be hyperphosphorylated in AD (S202/T205, T181, and T231) were studied in the rat pilocarpine status epilepticus (SE) model of temporal lobe epilepsy (TLE)." | 4.31 | Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy. ( Concepcion, FA; Ekstrom, NA; Estes, OO; Khan, MN; Poolos, NP, 2023) |
| " We recently found that in the pilocarpine-induced status epilepticus (PILO-SE) mouse model of TLE there was an increase in CA2 intrinsic excitability associated with a loss of CA2 synaptic inhibition." | 4.31 | Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. ( Barnett, A; Lisgaras, CP; Santoro, B; Scharfman, HE; Siegelbaum, SA; Whitebirch, AC, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 4.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " The anxiety induced by pilocarpine was also significantly (P < 0." | 4.12 | Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. ( Bum, EN; Kouemou Emegam, N; Neteydji, S; Pale, S; Taiwe, GS, 2022) |
| " This study aimed to analyze the changes in gene expression of mGluR subtypes (1-5, 7, 8) in various rat brain regions in the latent and chronic phases of a lithium-pilocarpine model of epilepsy." | 4.12 | Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy. ( Dyomina, AV; Kovalenko, AA; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Intrahippocampal pilocarpine microinjection (H-PILO) induces status epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents." | 4.12 | Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus. ( Amaral, MMC; Borbely, AU; Cummings, RD; de Araujo Costa, M; de Castro, OW; de Gusmão Taveiros Silva, NK; de Melo, IS; Dias-Baruffi, M; Donatti, ALF; Duzzioni, M; Fuzo, CA; Garcia-Cairasco, N; Gitaí, DLG; Mestriner, L; Pacheco, ALD; Santos, YMO; Silva, RS, 2022) |
| " First, at the beginning of epileptic chronic phase, 30 days post-pilocarpine-induced Status Epilepticus (SE)." | 4.02 | In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy. ( Calcagnotto, ME; Righes Marafiga, J; Vendramin Pasquetti, M, 2021) |
| " Here, we detected the VFRs in the hippocampal network and tracked their roles during status epilepticus (SE) in rats with pilocarpine-induced temporal lobe epilepsy (TLE)." | 4.02 | Roles of Very Fast Ripple (500-1000[Formula: see text]Hz) in the Hippocampal Network During Status Epilepticus. ( Cui, Y; Guo, D; Hao, J; Lin, Y; Niu, B; Xia, Y; Yao, D; Yu, L, 2021) |
| " Epilepsy was induced by lithium-pilocarpine-induced status epilepticus." | 4.02 | Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats. ( Annamalai, K; Kutty, BM; Nair, KP; Salaka, RJ; Shankaranarayana Rao, BS; Srikumar, BN, 2021) |
| " In the present study, we tested the effects of NRP2945 on the development of epilepsy (epileptogenesis) and on chronic, spontaneous seizures, by using the pilocarpine model of temporal lobe epilepsy." | 4.02 | Anti-epileptogenic effect of NRP2945 in the pilocarpine model of temporal lobe epilepsy. ( Falcicchia, C; Guarino, A; Ingusci, S; Lovisari, F; Marino, P; Sieg, F; Simonato, M; Soukupova, M; Thomas, M, 2021) |
| ") was administered 3 h after the pilocarpine-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.02 | Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy. ( Atanasova, D; Marinov, P; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y; Yoanidu, L, 2021) |
| "We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test." | 4.02 | Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test. ( Bocca Nejm, M; Cysneiros, RM; Finsterer, J; Guimarães-Marques, MJ; Scorza, CA; Scorza, FA; Victorino, DB, 2021) |
| " Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1β, IL-18, IL-6, and TNF-α) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE." | 3.96 | Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. ( He, J; Liu, S; Shen, K; Wei, Y; Wu, K; Yang, H; Yang, X; Yue, J; Zhang, C, 2020) |
| " Similarly, we found that both focal and generalized seizures coexist in some pilocarpine-induced chronic temporal lobe epilepsy (TLE) rats." | 3.96 | Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat ( Wang, Y; Xu, K; Yang, Y; Zhang, F; Zhu, J, 2020) |
| "To establish the effects induced by long-term, unilateral stimulation of parvalbumin (PV)-positive interneurons on seizures, interictal spikes, and high-frequency oscillations (80-500Hz) occurring after pilocarpine-induced status epilepticus (SE)-a proven model of mesial temporal lobe epilepsy (MTLE)-in transgenic mice expressing or not expressing ChR2." | 3.91 | Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy. ( Avoli, M; Chen, LY; Etter, G; Lévesque, M; Shiri, Z; Wang, S; Williams, S, 2019) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 3.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| " In this study we used the pilocarpine-induced status epilepticus model of TLE (i." | 3.91 | Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 3.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "The results of present study concluded that GBbf treatment suppressed lithium-pilocarpine induced spontaneous recurrent seizures severity and incidence with improved cognitive functions, reduced anxiety-like behavior and aggression." | 3.85 | Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video-electroencephalography (EEG) monitoring." | 3.85 | Neurosteroid-sensitive δ-GABA ( Joshi, S; Kapur, J; Rajasekaran, K; Williamson, J, 2017) |
| " In epileptic rats analyzed up to approximately two weeks after pilocarpine-induced status epilepticus (SE), these patterns are associated with specific high-frequency oscillation (HFO) content: ripples (80-200Hz) or fast-ripples (250-500Hz) predominate in LVF or HYP seizures, respectively." | 3.85 | Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Stroh, T, 2017) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 3.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " Using the lithium-pilocarpine model of temporal lobe epilepsy (TLE), we recently showed that inhibition of this receptor during the first ten days after pilocarpine-induced status epilepticus (SE) results in substantial anti-epileptogenic and neuroprotective effects." | 3.85 | Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. ( Bogovyk, R; Fedoriuk, M; Holmes, GL; Isaev, D; Isaeva, E; Krishtal, O; Lunko, O, 2017) |
| " In this study, we investigated how DGC birthdate influences participation in MFS and other aspects of axonal plasticity using the rat pilocarpine-induced status epilepticus (SE) model of mTLE." | 3.83 | Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy. ( Althaus, AL; Parent, JM; Zhang, H, 2016) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 3.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| " Using combined methods of behavioral testing, immunofluorescence and electrophysiological recordings, we characterized the anticonvulsant effect of RIN in a pilocarpine-induced status epilepticus (SE) rat model of temporal lobe epilepsy (TLE) and investigated the underlying cellular mechanisms." | 3.83 | Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy. ( Ji, WG; Mi, Z; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2016) |
| " Here, we perform a miRNA microarray analysis of the hippocampus of Wistar rats 24 hours after intra-hippocampal pilocarpine-induced Status Epilepticus (H-PILO SE)." | 3.83 | Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. ( Araújo, MA; Arroxelas-Silva, CL; Castro, OW; Duzzioni, M; Garcia-Cairasco, N; Góes Gitaí, DL; Kandratavicius, L; Leite, JP; Marques, TE; Octacílio-Silva, S; Paçó-Larson, ML; Passos, GA; Peixoto-Santos, JE; Pereira, MG, 2016) |
| "2 promoter activation, were imaged in vivo in the pilocarpine model of status epilepticus (SE)." | 3.81 | Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. ( Becker, AJ; Kulbida, R; Mandelkow, EM; Schoch, S; van Loo, KM; Wang, Y, 2015) |
| " We measured the expression of two subtypes of TRPC channels, TRPC3 and TRPC6, in temporal lobe epileptic foci excised from patients with intractable epilepsy and in hippocampus of mice with pilocarpine-induced status epilepticus (SE), an animal model of TLE." | 3.81 | Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy. ( Feng, L; Jiang, T; Liu, R; Long, X; Ma, Y; Tang, W; Tian, F; Xiao, B; Yuan, C; Zeng, C; Zhou, P, 2015) |
| "Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including pilocarpine-induced status epilepticus." | 3.81 | Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Thind, K; Yamawaki, R, 2015) |
| " This study evaluated the dynamin 1 expression pattern in the acute lithium-pilocarpine rat model and in patients with temporal lobe epilepsy (TLE) and investigated whether altering the dynamin 1 expression pattern affects epileptic seizures in vivo and in vitro." | 3.81 | Upregulated dynamin 1 in an acute seizure model and in epileptic patients. ( Chen, XN; Fan, XX; Fu, XW; Gu, J; Li, YY; Wang, XF; Wang, ZH; Xiao, Z; Zhang, YJ, 2015) |
| " Here we have examined hippocampal neuronal network activities in the pilocarpine post-status epilepticus model of limbic epileptogenesis and asked whether or not the docosahexaenoic acid (DHA)-derived lipid mediator, neuroprotectin D1 (NPD1), modulates epileptogenesis." | 3.81 | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. ( Bazan, NG; Musto, AE; Petasis, NA; Walker, CP, 2015) |
| " Status epilepticus evoked by pilocarpine administeration was used to induce epilepsy in rats." | 3.81 | Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients. ( Alsharafi, W; Xiao, B, 2015) |
| " To evaluate the possible roles of inhibitory neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of epileptic pilocarpine-treated rats as they experienced spontaneous seizures." | 3.81 | Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy. ( Buckmaster, PS; Fujita, S; Thamattoor, AK; Toyoda, I, 2015) |
| " This study aimed to assess αSNAP expression in temporal lobe epilepsy (TLE) patients and pilocarpine-induced rat model and to determine whether altered αSNAP expression leads to increased susceptibility to seizures." | 3.81 | Association of Alpha-Soluble NSF Attachment Protein with Epileptic Seizure. ( Deng, W; Li, J; Mi, X; Wang, L; Wang, N; Wang, X; Wang, Z; Xi, Z; Xiao, F, 2015) |
| " In this study, we used the pilocarpine model of MTLE to establish the effects of a third generation drug, lacosamide (LCM), on seizures, interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz)." | 3.81 | Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Ragsdale, D, 2015) |
| " This study aimed to investigate the expression pattern of Letm1 in patients with temporal lobe epilepsy (TLE) and pilocarpine-induced rat model of epilepsy, and to determine if altered Letm1 leads to mitochondrial dysfunction and increased susceptibility to seizures." | 3.80 | Association of mitochondrial letm1 with epileptic seizures. ( Cao, Q; Chen, G; Fang, M; Liu, J; Lu, Y; Luo, J; Wang, X; Zhang, X, 2014) |
| "To investigate the possible role of bone marrow-derived cells in angiogenesis after seizures, we induced SE by pilocarpine injection in previously prepared chimeric mice." | 3.80 | Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus. ( Bittencourt, S; Covolan, L; Garcia, Kde O; Longo, BM; Mello, LE; Paiva, Dde S; Romariz, SA, 2014) |
| "Lithium chloride-pilocarpine-induced rats with status epilepticus (SE) were established." | 3.80 | Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. ( Du, Y; Liu, W; Shi, R; Yang, W; Yu, W; Zhao, N; Zou, Y, 2014) |
| "Thirty-five Sprague-Dawley rats were subjected to lithium-pilocarpine status epilepticus." | 3.80 | Attention and executive functions in a rat model of chronic epilepsy. ( Akimana, G; Barbelivien, A; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Herbeaux, K; Koning, E; Marques-Carneiro, JE; Nehlig, A, 2014) |
| " Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the main features of mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) in humans, we examined the expression of CB1R in hippocampal astrocytes of epileptic rats." | 3.80 | Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi. ( Jiang, W; Kang, JJ; Li, J; Liu, YY; Ma, L; Meng, XD; Ou-Yang, TP; Wei, D; Wu, C; Yang, F; Zhu, GM, 2014) |
| " And that VMAT2 protein transiently increased in acute stages (1 day and 3 days) after epileptic seizures in pilocarpine-treated rats; however, it clearly decreased after spontaneous recurrent seizures (7 days, 21 days, and 60 days after seizures)." | 3.79 | Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats. ( Cao, Q; Chen, G; Chen, Y; Guo, F; Jiang, G; Li, J; Liu, X; Wang, X; Wang, Z; Zhang, Y, 2013) |
| " The present paper is the continuation of our previous study which has shown an increased occurrence of creatine inclusions in rat hippocampal formations from the acute phase of pilocarpine-induced status epilepticus (SE) and positive correlation between their quantity and the total time of seizure activity within the observation period." | 3.79 | Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy. ( Chwiej, J; Dumas, P; Janeczko, K; Kutorasinska, J; Sandt, C; Setkowicz, Z, 2013) |
| "Subconvulsant doses of pilocarpine promote long-lasting alterations on neural circuitry, reflected by an increased theta activity in the hippocampus and an anxiety-like profile of rats evaluated 1 month after the treatment which is independent of seizure occurrence and is not related to changes in glutamate uptake or hippocampal damage." | 3.79 | Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? ( Carobrez, AP; De Lima, TC; Duarte, FS; Duzzioni, M; Ern, AL; Gavioli, EC; Hoeller, AA; Lemos, T; Piermartiri, TC; Silva, NM; Tasca, CI, 2013) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 3.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| " To measure directly the long-term effects of pilocarpine-induced status epilepticus on vesicular release and recycling in hippocampal mossy fibre presynaptic boutons, we used (i) two-photon imaging of FM1-43 vesicular release in rat hippocampal slices; and (ii) transgenic mice expressing the genetically encoded pH-sensitive fluorescent reporter synaptopHluorin preferentially at glutamatergic synapses." | 3.78 | Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy. ( Garrido-Sanabria, ER; Jones, T; Maglakelidze, G; Otero, R; Pacheco, LF; Partida, C; Romanovicz, D; Skinner, F; Stanton, PK; Thakker, R; Upreti, C; Velíšek, L; Velíšková, J; Zhou, ZY, 2012) |
| " Results from 2413 mice were evaluated for effects of sex, age, body weight, and latency between administration of atropine methyl bromide and pilocarpine." | 3.78 | Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Haney, MM, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 3.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| "The lithium-pilocarpine-induced status epilepticus model and the temporal lobe epilepsy model were established in Sprague-Dawley rats." | 3.78 | MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus. ( Feng, L; Hu, K; Li, Y; Long, HY; Long, LL; Ouyang, DS; Sun, DN; Xiao, B; Xie, YY; Zhang, C, 2012) |
| " In the study, one of the status epilepticus animal models of epilepsy was used, namely the model of temporal lobe epilepsy with pilocarpine-induced seizures." | 3.78 | Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study. ( Appel, K; Chwiej, J; Gzielo-Jurek, K; Janeczko, K; Kutorasinska, J; Setkowicz, Z; Simon, R; Uram, L, 2012) |
| " Here, we describe a real time quantitative PCR (qPCR) approach to investigate relative changes in the expression of STREX and ZERO splice variants using a newly designed set of probes and primers for TaqMan-based qPCR analysis of cDNA from the rat dentate gyrus at different time points following pilocarpine-induced status epilepticus." | 3.77 | Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. ( Arshadmansab, MF; Ermolinsky, BS; Garcia, I; Garrido-Sanabria, ER; Otalora, LF; Skinner, F; Zarei, MM, 2011) |
| "We analyzed corticostriatal long-term potentiation (LTP) in brain slices of pilocarpine-treated rats after status epilepticus (SE)." | 3.77 | Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy. ( Avchalumov, Y; Kirschstein, T; Köhling, R, 2011) |
| "After pilocarpine-induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus." | 3.77 | Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy. ( Cameron, MC; Nadler, JV; Zhan, RZ, 2011) |
| "Status epilepticus was induced by systemic pilocarpine treatment in green fluorescent protein (GFP)-expressing inhibitory nerurons (GIN) mice in which a subset of somatostatin interneurons expresses GFP." | 3.77 | Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Wen, X, 2011) |
| "Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats." | 3.77 | Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. ( Cox, CB; Ermolinsky, BS; Farrell, B; Garrido-Sanabria, ER; Nair, S; Pacheco, LF; Ruiz, N, 2011) |
| " A significant loss of total dorsal subicular neurons, particularly calbindin, parvalbumin (PV) and immunopositive interneurons, was found at 2 months after pilocarpine-induced status epilepticus (SE)." | 3.76 | Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus. ( Bragin, A; Engel, J; He, DF; Ma, DL; Tang, FR; Tang, YC, 2010) |
| " To test this hypothesis, the anticonvulsant effect of a low dose of LPS against seizures elicited by pilocarpine hydrochloride was measured." | 3.76 | Behavioural and histological effects of preconditioning with lipopolysaccharide in epileptic rats. ( Cybulska, R; Dmowska, M; Gawron, A; Jaworska-Adamu, J; Piersiak, T; Schoenborn, R, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " To better define the role of increased homocysteine in epilepsy, we analyzed the effects of homocysteine pretreatment in the pilocarpine model of status epilepticus (SE), which is used to mimic temporal lobe epilepsy (TLE) in rodents." | 3.76 | Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment. ( Agnati, LF; Andreoli, N; Baldelli, E; Biagini, G; Fuxe, K; Leo, G, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| " A pilocarpine-induced status epilepticus mouse model of TLE was used to study the effect of cannabinoid agonists on recurrent excitatory circuits of the dentate gyrus using electrophysiological recordings in hippocampal slices isolated from control mice and mice with TLE." | 3.76 | Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. ( Bhaskaran, MD; Smith, BN, 2010) |
| " We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent with a depressive state: behavioral equivalents of anhedonia and despair, dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, and compromised raphe-hippocampal serotonergic transmission." | 3.76 | Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D, 2010) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 3.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 3.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Rapamycin was focally, continuously, and unilaterally infused into the dorsal hippocampus for prolonged periods beginning within hours after rats sustained pilocarpine-induced status epilepticus." | 3.75 | Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. ( Buckmaster, PS; Ingram, EA; Wen, X, 2009) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 3.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus." | 3.74 | Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 3.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 3.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "Sixty-one SD rats underwent intraperitoneal injection of lithium chloride and pilocarpine to establish models of status epilepticus characterized with temporal lobe epilepsy." | 3.74 | [Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy]. ( Chen, YC; Huang, YG; Lin, H; Wen, XN; Wu, LW, 2007) |
| " The recordings were performed in epileptic rats 24 h after an early behavioural spontaneous seizure between 5 and 21 days after pilocarpine-induced status epilepticus." | 3.74 | Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. ( Mello, LE; Queiroz, CM, 2007) |
| " The purposes of this study were to characterize the role of adenosine receptors in modulating status epilepticus (SE) induced by pilocarpine and evaluate its neuroprotective action." | 3.73 | Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. ( Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP, 2005) |
| " After 2 days of infusion, rats were treated with pilocarpine to induce status epilepticus." | 3.73 | Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy. ( Buckmaster, PS; Toyoda, I, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " In this study, we investigated whether increased generation of FR during status epilepticus would be sufficient to provoke abnormalities in mtDNA and in the expression and activity of cytochrome c oxidase (CCO), complex IV of the respiratory chain, in the chronic phase of the pilocarpine model of temporal lobe epilepsy." | 3.73 | Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine. ( Amado, D; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Nasseh, IE; Tengan, CH, 2006) |
| " Recently, we reported eIF2alpha(P) (phosphorylated eIF2alpha) in the brain during SE (status epilepticus) induced by pilocarpine in mice, an animal model of TLE (temporal lobe epilepsy) [Carnevalli, Pereira, Longo, Jaqueta, Avedissian, Mello and Castilho (2004) Neurosci." | 3.73 | Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus. ( Alves, VS; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Mello, LE; Paiva, VN; Pereira, CM; Vattem, KM; Wek, RC, 2006) |
| " Furthermore, we examined whether the MRP2 protein is overexpressed after experimentally induced seizures in rats, using the pilocarpine model of temporal lobe epilepsy." | 3.73 | Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. ( Gastens, AM; Hoffmann, K; Löscher, W; Volk, HA, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 3.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| "Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)." | 3.73 | The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "To determine whether a pharmacologic treatment could delay or prevent the epileptogenesis induced by status epilepticus (SE) through the protection of some brain areas, we studied the effects of the long-term exposure to pregabalin (PGB) on neuronal damage and epileptogenesis induced by lithium-pilocarpine SE." | 3.72 | Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat. ( André, V; Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA, 2003) |
| " To assess this hypothesis, the pilocarpine model of temporal lobe epilepsy was selected because an important reorganization of the glutamatergic network, which includes an aberrant sprouting of granule cell axons, neo-synaptogenesis, and dendritic spine remodeling, is well established in the dentate gyrus." | 3.72 | Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures. ( Ben-Ari, Y; Esclapez, M; Fattoum, A; Ferhat, L; Represa, A; Shirao, T, 2003) |
| "We induced status epilepticus in rats, by using lithium-pilocarpine, and then 2-12 weeks later, used whole-cell voltage-clamp to examine voltage-activated sodium currents of acutely dissociated layer V neurons." | 3.72 | Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy. ( Agrawal, N; Alonso, A; Ragsdale, DS, 2003) |
| "Adult rats were treated with pilocarpine to induce status epilepticus." | 3.72 | Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats. ( Buckmaster, PS, 2004) |
| " After pilocarpine-induced status epilepticus (SE) in mice most hilar neurons died and neuropeptide Y (NPY) immunoreactivity appeared in the dentate inner molecular layer (IML) after 10-31 days indicative of MFS." | 3.72 | Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice. ( Borges, K; Dingledine, R; McDermott, DL, 2004) |
| "To quantify the variability in thermal pain perception of rats with chemically induced brain injury following subcutaneous lithium and pilocarpine administration, 9 female Wistar rats were subjected to a nociceptive (hotplate) paradigm." | 3.72 | Elevated nociceptive thresholds in rats with multifocal brain damage induced with single subcutaneous injections of lithium and pilocarpine. ( Galic, MA, 2004) |
| "To analyze whether the subcellular localization of the messenger RNAs (mRNAs) coding for the neurotrophin brain-derived neurotrophic factor (BDNF), its receptor TrkB, and the alpha and beta subunits of calcium-calmodulin-dependent kinase II (CaMKII) are modified after pilocarpine and kindled seizures." | 3.71 | Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy. ( Armellin, M; Bregola, G; Del Piccolo, P; Rodi, D; Simonato, M; Tongiorgi, E; Zucchini, S, 2002) |
| " As in patients, the consequences of the lithium-pilocarpine-induced status epilepticus (SE) are age dependent, and only a subset of 21-day-old rats will develop epilepsy." | 3.71 | Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model. ( Leroy, C; Namer, IJ; Nehlig, A; Roch, C, 2002) |
| " In adult rats, the only effective dose and agent was 125 ng V2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate." | 3.71 | Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy. ( Gulec, G; Noyan, B, 2002) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 3.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 3.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 3.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " In the present study, glutamatergic modulation of GABAA receptor-mediated inhibition was investigated by whole-cell patch clamp recordings from visualized hippocampal dentate granule cells (DGCs) in slices that were prepared from surgically-removed human medial temporal lobe specimens and the rat pilocarpine model of temporal lobe epilepsy." | 3.70 | Modulation of GABAA receptor-mediated inhibition by postsynaptic calcium in epileptic hippocampal neurons. ( Isokawa, M, 1998) |
| "In the rat pilocarpine model, dendrites of DGCs revealed a generalized spine loss immediately after the acute status epilepticus induced by pilocarpine." | 3.70 | Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model. ( Isokawa, M, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 3.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| " The present study determined whether status epilepticus-induced HBDs on dentate granule cells occur in the pilocarpine model of temporal lobe epilepsy and whether these dendrites are targeted by mossy fibers." | 3.70 | Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry. ( Nadler, JV; Okazaki, MM; Ribak, CE; Spigelman, I; Tran, PH, 2000) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 3.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 3.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Interictal activity and seizures are the hallmarks of focal epileptic disorders (which include mesial temporal lobe epilepsy, MTLE) in humans and in animal models." | 3.01 | Evolution of interictal activity in models of mesial temporal lobe epilepsy. ( Avoli, M; Lévesque, M; Macey-Dare, ADB; Salami, P; Wang, S, 2023) |
| "Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization." | 2.41 | Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002) |
| "Epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures." | 1.91 | Upregulation of SLITRK5 in patients with epilepsy and in a rat model. ( Ai, M; Chen, H; Chen, L; Liu, Y; Mei, R; Pang, R; Xia, D; Zhang, L; Zhong, L, 2023) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 1.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy." | 1.91 | Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats. ( Diespirov, GP; Griflyuk, AV; Kalita, AD; Postnikova, TY; Sinyak, DS; Zaitsev, AV; Zubareva, OE, 2023) |
| "In the PV-ChR2 day 13 group, rates of seizures (p < 0." | 1.72 | Bilateral optogenetic activation of inhibitory cells favors ictogenesis. ( Avoli, M; Etter, G; Lévesque, M; Wang, S; Williams, S, 2022) |
| "Gastrodin reduced the acute seizure severity in lithium-pilocarpine-induced seizure model." | 1.62 | Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. ( Chiu, SC; Huang, CW; Lai, MC; Liu, PY; Wu, SN; Yang, CS, 2021) |
| "Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions." | 1.62 | Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021) |
| "SE frequently induces chronic recurrent seizures after an extended latency referred to as epileptogenesis." | 1.51 | Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. ( Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H, 2019) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "Inflammation is a hallmark of epileptogenic brain tissue." | 1.51 | Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain. ( Benifla, M; Ekstein, D; Eyal, S; Han, H; Mann, A; Polyak, B; Portnoy, E; Shmuel, M, 2019) |
| "Temporal lobe epilepsy is associated with significant structural pathology in the hippocampus." | 1.51 | Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction. ( Coulter, DA; Kahn, JB; Port, RG; Takano, H; Yue, C, 2019) |
| "Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures." | 1.48 | Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. ( Cavalheiro, EA; Gomes da Silva, S; Marques, MJG; Naffah-Mazzacoratti, MDG; Scorza, CA; Scorza, FA, 2018) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "In the acute seizure model, both the behavioral and electrographic seizure activities were record and analyzed in rats for 90min, starting immediately after pilocarpine injection." | 1.46 | Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats. ( Chen, Y; Feng, Y; Han, X; Li, J; Liu, H; Mi, X; Wang, N; Wang, X; Zhang, Y; Zhao, T, 2017) |
| "The search for new treatments for seizures and epilepsy relies upon studies in animal models of epilepsy." | 1.46 | Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique. ( Anbazhagan, A; Chen, M; Reutens, DC; Tieng, QM, 2017) |
| "Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation." | 1.46 | Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2017) |
| "Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available." | 1.46 | Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis. ( Liang, LP; Patel, M; Pearson, JN; Roberts, LJ; Warren, E, 2017) |
| "The reduction on seizure burden was associated with a limited reduction on the generation of SBDPs but was correlated with a reduction in astrocytosis, microglia activation and cell sprouting." | 1.46 | A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. ( Carlsen, J; González, MI; Lam, PM, 2017) |
| "Once spontaneous seizures were established, we tested the locomotor activity (open field), spatial working memory (eight-arm radial maze), and sensorimotor gating (prepulse inhibition of acoustic startle)." | 1.43 | The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions. ( Bueno-Júnior, LS; Do Val Da Silva, RA; Kandratavicius, L; Leite, JP; Lopes-Aguiar, C; Wolf, DC, 2016) |
| "Sham-treated pilocarpine rats but not sunitinib-treated pilocarpine rats had significantly smaller hippocampi." | 1.43 | Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy? ( Avoli, M; Benini, R; Khoja, Z; Roth, R; Wintermark, P, 2016) |
| "The pilocarpine model has been recognized as an animal model of TLE." | 1.43 | Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy. ( Costa, AP; de Mello, N; Farina, M; Gonçalves, FM; Leal, RB; Lopes, MW; Lopes, SC; Prediger, RD; Santos, DB; Walz, R, 2016) |
| "Temporal lobe epilepsy is a common and challenging clinical problem, and its pathophysiological mechanisms remain unclear." | 1.43 | More Docked Vesicles and Larger Active Zones at Basket Cell-to-Granule Cell Synapses in a Rat Model of Temporal Lobe Epilepsy. ( Buckmaster, PS; Thind, K; Yamawaki, R, 2016) |
| "Pilocarpine was administered by a ramp-up dosing protocol that allows determining interindividual differences in susceptibility to the convulsant." | 1.43 | The pilocarpine model of temporal lobe epilepsy: Marked intrastrain differences in female Sprague-Dawley rats and the effect of estrous cycle. ( Bankstahl, M; Brandt, C; Klee, R; Löscher, W; Töllner, K, 2016) |
| "Levetiracetam (LEV) is a novel anti-epileptic drug (AED) used to treat partial seizures and idiopathic generalized epilepsy." | 1.43 | Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats. ( Ge, YX; Lin, YY; Liu, XY; Tian, XZ, 2016) |
| "Neuroinflammation is known to be involved in epileptogenesis with unclear mechanisms." | 1.42 | Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. ( Hung, SW; Hung, YW; Lai, MT; Lee, TS; Lin, YY; Shih, YH; Wong, LK; Wu, YC, 2015) |
| "However, whether ENT1 plays a role in epileptic seizure that involves elevated glutamatergic neurotransmission is unknown." | 1.42 | ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission. ( Chen, G; Chen, Y; Fang, M; Liu, J; Luo, J; Lv, Y; Wang, J; Wang, K; Wang, X; Xu, P; Xu, Z; Zhang, J; Zhang, Y, 2015) |
| "In pilocarpine-treated animals, β-AR-mediated LTP was strongly reduced in the distal subiculum." | 1.42 | Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy. ( Bartsch, JC; Behr, J; Gilling, KE; Grosser, S; Heinemann, U; Hollnagel, JO, 2015) |
| " To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing strategy to produce spontaneous recurring seizures in immunodeficient NodScid mice." | 1.42 | Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice. ( Ahn, S; Chung, S; Cunningham, M; Iskandar, D; Kim, KS; Kim, Y; Leung, A; Luna, MJ; Savvidis, G, 2015) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 1.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "Only 29% of LEV-treated animals had seizures compared to all controls following a latent period that was similar in duration." | 1.42 | The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M, 2015) |
| "Epilepsy is a frequent neurological disorder that affects directly 0." | 1.42 | The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus. ( Orbán-Kis, K; Szabadi, T; Szilágyi, T, 2015) |
| "The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests." | 1.42 | Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy. ( Frolova, EV; Kalemenev, SV; Kim, KKh; Lavrentyeva, VV; Lukomskaya, NY; Magazanik, LG; Sizov, VV; Zaitsev, AV; Zubareva, OE, 2015) |
| "Temporal lobe epilepsy is associated with dysfunctional brain networks." | 1.40 | Abnormal metabolic connectivity in the pilocarpine-induced epilepsy rat model: a multiscale network analysis based on persistent homology. ( Choi, H; Chung, JK; Hwang, DW; Im, HJ; Kang, H; Kim, EE; Kim, YK; Lee, DS; Lee, H, 2014) |
| "Tenidap treatment significantly reduced neuronal damage in the CA3 area (P < 0." | 1.39 | Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy. ( Fang, YX; Hong, Z; Tang, XH; Wang, JH; Wu, XY; Xu, L; Zhu, GX, 2013) |
| "In pilocarpine-treated animals, this long-term depression persisted in older animals, indicating impaired maturation of the dentate gyrus." | 1.39 | Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy. ( Behr, J; Gilling, KE; Oltmanns, F, 2013) |
| "First, we repeatedly determined the PTZ seizure threshold by i." | 1.38 | Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. ( Brandt, C; Löscher, W; Rattka, M, 2012) |
| " We used male NMRI mice (28-32 g) and first established the dose-response relationship for pilocarpine (250-400 mg/kg; ip) to induce status epilepticus (SE)." | 1.38 | Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. ( Kaminski, RM; Kumar, G; Mazzuferi, M; Rospo, C, 2012) |
| "The comorbidity between epilepsy and Alzheimer's disease (AD) is a topic of growing interest." | 1.38 | Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. ( Cai, H; Cai, Y; Deng, SH; Laferla, FM; Luo, XG; Oddo, S; Patrylo, PR; Rose, GM; Shelton, J; Yan, XX, 2012) |
| "Temporal lobe epilepsy is one of the most common types of epilepsy." | 1.37 | Improvement of the pilocarpine epilepsy model in rat using bone marrow stromal cell therapy. ( Abdanipour, A; Mirnajafi-Zadeh, J; Tiraihi, T, 2011) |
| "Six pilocarpine-treated Wistar rats exhibiting spontaneous recurrent seizures and nine control rats were studied with PET using [(18)F]-fallypride, a high-affinity dopamine D(2/3) receptor ligand." | 1.36 | In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy. ( Bartenstein, P; Buchholz, HG; Cumming, P; Debus, F; Dupont, E; Fellgiebel, A; Heimann, A; Landvogt, C; Luhmann, HJ; Potschka, H; Schreckenberger, M; Tillmanns, J; Werhahn, KJ; Yakushev, IY, 2010) |
| "Parecoxib was administered twice daily at 10 mg/kg for 18 days following SE." | 1.36 | The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. ( Bankstahl, M; Löscher, W; Polascheck, N, 2010) |
| " Based on pharmacokinetic studies with bumetanide, which showed extremely rapid elimination and low brain penetration of this drug in rats, bumetanide was administered systemically with different dosing protocols, including continuous intravenous infusion." | 1.36 | Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. ( Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M, 2010) |
| "It has long been held that chronic seizures cause blood-brain barrier (BBB) damage." | 1.36 | Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity. ( Bawa, H; Desai, NK; Fan, Q; Ghosh, C; Janigro, D; Marchi, N; Masaryk, TK; Nguyen, MT; Rasmussen, P; Teng, Q, 2010) |
| "Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood." | 1.35 | Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 1.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Temporal lobe epilepsy is common and difficult to treat." | 1.35 | Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Zhang, W, 2009) |
| "The data indicate that seizure-induced glutamate release is involved in the regulation of Pgp expression, which can be blocked by MK-801." | 1.35 | Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. ( Bankstahl, JP; Bethmann, K; Hoffmann, K; Löscher, W, 2008) |
| " In order to ensure the occurrence of status epilepticus (SE) and decrease mortality, individual dosing of pilocarpine was performed by ramping up the dose until onset of SE." | 1.34 | Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice. ( Gröticke, I; Hoffmann, K; Löscher, W, 2007) |
| "In pilocarpine-treated rats the subiculum showed cell loss of about 30%." | 1.33 | Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy. ( Behr, J; Heinemann, U; Kivi, A; Knopp, A; Wozny, C, 2005) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 1.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "In pilocarpine-treated rats, the mEC showed a moderate layer III cell loss and an enhanced susceptibility to epileptiform discharges compared to control animals." | 1.33 | Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats. ( Behr, J; Gabriel, S; Heinemann, U; Jandova, K; Schulze, K; Wozny, C, 2005) |
| "Cycloheximide-treated animals differed from Pilo animals in the extent of hilar loss and supragranular mossy fiber sprouting as well as tissue shrinkage in the dorsal hippocampus." | 1.33 | Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy. ( Blanco, MM; Dos Santos, JG; Longo, BM; Mello, LE; Menezes de Oliveira, MG, 2005) |
| "Pilocarpine-treated animals represent an established model of mesial temporal lobe epilepsy." | 1.33 | Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. ( Avoli, M; Baldelli, E; Biagini, G; D'Antuono, M; D'Arcangelo, G; Tancredi, V, 2005) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its pathophysiology remains unclear." | 1.33 | Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kumar, SS, 2006) |
| "Herbimycin-treated animals developed spontaneous recurrent seizures, as did control animals, with a similar latency for the appearance of the first seizure and similar seizure frequency." | 1.33 | Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy. ( Mello, LE; Queiroz, CM, 2006) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its underlying mechanisms are unclear." | 1.32 | Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kobayashi, M; Wen, X, 2003) |
| "In pilocarpine-treated animals, the normal diffuse labeling of the delta subunit in the dentate molecular layer was decreased by 4 d after status epilepticus (latent period) and remained low throughout the period of chronic seizures." | 1.32 | Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. ( Houser, CR; Huang, CS; Mody, I; Peng, Z; Stell, BM, 2004) |
| "The data indicate that recurrent seizures which persistently occur in this model were not responsible for the increased DeltaFosB expression." | 1.31 | Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy. ( DeLorenzo, RJ; Jafari, N; Morris, TA, 2000) |
| "In pilocarpine-treated rats, however, kappa receptor-mediated effects were seen in both ventral and more dorsal sections." | 1.30 | Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. ( Chavkin, C; Simmons, ML; Terman, GW, 1997) |
| "In pilocarpine-treated animals an augmentation of rises in [K+]o was restricted to SP and its immediate vicinity." | 1.30 | Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats. ( Eilers, A; Gabriel, S; Heinemann, U; Kivi, A; Kovacs, R; Lehmann, TN; Schulze, K, 1998) |
| "Temporal lobe epilepsy is the most prevalent seizure disorder in adults." | 1.30 | Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. ( Brooks-Kayal, AR; Coulter, DA; Jin, H; Rikhter, TY; Shumate, MD, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.20) | 18.7374 |
| 1990's | 22 (4.38) | 18.2507 |
| 2000's | 157 (31.27) | 29.6817 |
| 2010's | 252 (50.20) | 24.3611 |
| 2020's | 70 (13.94) | 2.80 |
| Authors | Studies |
|---|---|
| Henkel, ND | 1 |
| Smail, MA | 1 |
| Wu, X | 1 |
| Enright, HA | 1 |
| Fischer, NO | 1 |
| Eby, HM | 1 |
| McCullumsmith, RE | 1 |
| Shukla, R | 1 |
| Xiang, T | 1 |
| Luo, X | 1 |
| Zeng, C | 2 |
| Li, S | 3 |
| Ma, M | 1 |
| Wu, Y | 1 |
| Righes Marafiga, J | 1 |
| Vendramin Pasquetti, M | 1 |
| Calcagnotto, ME | 2 |
| Song, LJ | 1 |
| Zhang, H | 6 |
| Qu, XP | 1 |
| Jin, JG | 1 |
| Wang, C | 2 |
| Jiang, X | 1 |
| Gao, L | 2 |
| Li, G | 2 |
| Wang, DL | 1 |
| Shen, LL | 1 |
| Liu, B | 1 |
| Dubey, V | 2 |
| Dey, S | 1 |
| Dixit, AB | 2 |
| Tripathi, M | 2 |
| Chandra, PS | 2 |
| Banerjee, J | 2 |
| Vigier, A | 1 |
| Partouche, N | 1 |
| Michel, FJ | 1 |
| Crépel, V | 1 |
| Marissal, T | 1 |
| Pale, S | 1 |
| Neteydji, S | 1 |
| Taiwe, GS | 1 |
| Kouemou Emegam, N | 1 |
| Bum, EN | 1 |
| Postnikova, TY | 3 |
| Diespirov, GP | 3 |
| Amakhin, DV | 1 |
| Vylekzhanina, EN | 1 |
| Soboleva, EB | 1 |
| Zaitsev, AV | 8 |
| Pascoal, VDB | 2 |
| Marchesini, RB | 1 |
| Athié, MCP | 1 |
| Matos, AHB | 2 |
| Conte, FF | 1 |
| Pereira, TC | 1 |
| Secolin, R | 1 |
| Gilioli, R | 2 |
| Malheiros, JM | 3 |
| Polli, RS | 1 |
| Tannús, A | 3 |
| Covolan, L | 6 |
| Pascoal, LB | 1 |
| Vieira, AS | 2 |
| Cavalheiro, EA | 23 |
| Cendes, F | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vitamin D on Gene Expression Profile of Breast Cancer Samples From Post-menopausal Patients[NCT00926315] | 60 participants (Anticipated) | Interventional | 2007-07-31 | Active, not recruiting | |||
| Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease[NCT04650932] | 10 participants (Anticipated) | Interventional | 2022-10-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for pilocarpine and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Evolution of interictal activity in models of mesial temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pil | 2023 |
The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Pilocarpine; Rats; Rode | 2021 |
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Temporal Lobe; | 2014 |
Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kaini | 2016 |
Chemically-induced TLE models: Topical application.
Topics: Administration, Topical; Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epile | 2016 |
High-frequency oscillations and mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine | 2018 |
The pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal L | 2008 |
The pilocarpine model of epilepsy: what have we learned?
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Exe | 2009 |
Cyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Mice; Neuronal | 2010 |
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor | 2002 |
Concise review: prospects of stem cell therapy for temporal lobe epilepsy.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Cell Differentiation; Disease Models, Animal; | 2007 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; | 2007 |
490 other studies available for pilocarpine and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Biomarkers; Datasets as Topic; Disease Models, Animal; Drug Discovery; Epi | 2021 |
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Convulsants; Epilepsy, Temporal Lobe; Ferroptosis; Gen | 2021 |
In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; | 2021 |
Increased expression of Rho-associated protein kinase 2 confers astroglial Stat3 pathway activation during epileptogenesis.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilocarpi | 2022 |
Differential glutamate receptor expression and function in the hippocampus, anterior temporal lobe and neocortex in a pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentia | 2022 |
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Male; Mice; Pilocarpine; Seizures; | 2021 |
Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cymbopogon; Disease Models, Animal; Dose-Res | 2022 |
Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Long-Term Potentiati | 2021 |
Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; | 2023 |
The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/
Topics: Animals; Apoptosis; beta Catenin; Computational Biology; Disease Models, Animal; Down-Regulation; Ep | 2022 |
Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Lithium; Pi | 2022 |
Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Group IV Phospholipases A2; Hipp | 2022 |
CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Humans; Mossy Fibers, Hippocampal; Piloca | 2022 |
Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mammals; Mice; Mossy Fibers, | 2022 |
Bilateral optogenetic activation of inhibitory cells favors ictogenesis.
Topics: Animals; Epilepsy, Temporal Lobe; Mice; Optogenetics; Pilocarpine; Seizures; Status Epilepticus | 2022 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation | 2022 |
Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromatography, Liquid; Disease Models, | 2022 |
Negative effects of brain regulatory T cells depletion on epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilo | 2022 |
Multi-omic Analysis of the Gut Microbiome in Rats with Lithium-Pilocarpine-Induced Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Gastrointestinal Microbiome; Lithium; Pilocarpine; Rats | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interl | 2022 |
Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Huma | 2022 |
Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Galectin 1; Hippocampus; Neuroprotective A | 2022 |
Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mice; Neurogenesis; Pilocarp | 2022 |
Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy.
Topics: Animals; Connexins; Epilepsy; Epilepsy, Temporal Lobe; Mice; Neuroinflammatory Diseases; Pilocarpine | 2022 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Upregulation of SLITRK5 in patients with epilepsy and in a rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Neocortex; Pilocarp | 2023 |
Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mice; Pilocarpine; Up-Regulation | 2023 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Optogenetic activation of septal inhibitory cells abates focal seizures.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Optogenetics; Parvalbum | 2023 |
Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Pilocarpin | 2023 |
Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mo | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufen | 2023 |
GL-II-73, a Positive Allosteric Modulator of α5GABA
Topics: Animals; Disease Models, Animal; Dopamine; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Qualit | 2023 |
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe | 2023 |
Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2023 |
Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin | 2023 |
Differential patterns of very high-frequency oscillations in two seizure types of the pilocarpine-induced TLE model.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Mice; Pilocarpine; Seizures | 2023 |
Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mefloquine; Neuropr | 2023 |
Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Epilepsy, Temporal Lobe; Interneurons; Male; Mice; Mi | 2019 |
Upregulated SHP-2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model.
Topics: Adolescent; Adult; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fem | 2020 |
Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; | 2020 |
Microstructure and functional connectivity-based evidence for memory-related regional impairments in the brains of pilocarpine-treated rats.
Topics: Amygdala; Animals; Brain; Diffusion Tensor Imaging; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hipp | 2020 |
Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Brain Waves; Connectome; Disease Models, Animal; Electrocorticography; Epilepsy, Temporal L | 2020 |
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.
Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Encephalitis; Epilepsy | 2020 |
Effects of Non-invasive, Targeted, Neuronal Lesions on Seizures in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Feasibility Studies; | 2020 |
CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage.
Topics: Animals; Apoptosis; Brain; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Disea | 2019 |
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Topics: Age Factors; Animals; Apoptosis; Astrocytes; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hi | 2020 |
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal L | 2020 |
Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; High-Throughput | 2020 |
The Runx1/Notch1 Signaling Pathway Participates in M1/M2 Microglia Polarization in a Mouse Model of Temporal Lobe Epilepsy and in BV-2 Cells.
Topics: Animals; Cell Line; Cell Polarity; Core Binding Factor Alpha 2 Subunit; Epilepsy, Temporal Lobe; Gen | 2020 |
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Circulating MicroRNA; Disease Models, Animal; Electri | 2020 |
Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Female; Male; Mice; Mice, Inbred C57BL; Microglia; Neu | 2020 |
Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine; Rats; Seizures | 2020 |
Multi-omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Proteomics; Rats; Rats, Wistar | 2021 |
d-Serine Intervention In The Medial Entorhinal Area Alters TLE-Related Pathology In CA1 Hippocampus Via The Temporoammonic Pathway.
Topics: Animals; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; Serine | 2021 |
Bioinformatic analysis identifies key transcriptome signatures in temporal lobe epilepsy.
Topics: Animals; Computational Biology; Epilepsy, Temporal Lobe; Humans; Male; Pilocarpine; Protein Interact | 2020 |
Roles of Very Fast Ripple (500-1000[Formula: see text]Hz) in the Hippocampal Network During Status Epilepticus.
Topics: Animals; Brain Waves; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; Status Epilepticus | 2021 |
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Topics: Animals; Anticonvulsants; Benzyl Alcohols; Disease Models, Animal; Electroencephalography; Epilepsy, | 2021 |
Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons.
Topics: Animals; Anticonvulsants; Cytoskeletal Proteins; Disease Models, Animal; Drugs, Chinese Herbal; Epil | 2021 |
Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Ep | 2021 |
Alkaline brain pH shift in rodent lithium-pilocarpine model of epilepsy with chronic seizures.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Drug Resistant Epilepsy; Epile | 2021 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calbindins; Environment; Epilepsy, Tempor | 2021 |
Anti-epileptogenic effect of NRP2945 in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Convulsants; Epilepsy, Temporal Lobe; Male; Neu | 2021 |
Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Behavior, Animal; D | 2021 |
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop | 2021 |
Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Electroencephalography; Ep | 2021 |
GPER1 Modulates Synaptic Plasticity During the Development of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Learning; Lithium Chloride; Male; Membrane Proteins; | 2021 |
Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test.
Topics: Animals; Dietary Supplements; Epilepsy; Epilepsy, Temporal Lobe; Fish Oils; Morris Water Maze Test; | 2021 |
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Topics: Animals; ARNTL Transcription Factors; Biological Clocks; Circadian Rhythm; Epilepsy, Temporal Lobe; | 2021 |
The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Epilepsy, Tempor | 2017 |
Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation.
Topics: Aggression; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain; Depression; Epilepsy, Tempor | 2017 |
Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Cells, Cultured; Child; Diazepam; Disease Models, Animal; Enzyme Inhibitor | 2016 |
Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy.
Topics: Anesthetics; Animals; Brain; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, | 2017 |
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.
Topics: Adolescent; Adult; Animals; B-Cell Activating Factor; B-Cell Activation Factor Receptor; Blotting, W | 2017 |
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Nerve De | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra | 2017 |
Neurosteroid-sensitive δ-GABA
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Down-Regulat | 2017 |
Rabies tracing of birthdated dentate granule cells in rat temporal lobe epilepsy.
Topics: Age Factors; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Disease Model | 2017 |
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anticonvulsants; Apoptosis; Blood-Brain B | 2017 |
Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy; Epilepsy | 2017 |
Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Circadian Rhythm; Cluster Analysis; Disease Models, Animal; Electroencepha | 2017 |
The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Disease Models, Animal; Drug R | 2017 |
Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electrocorticography; Entorhinal | 2017 |
Altered axon initial segment in hippocampal newborn neurons, associated with recurrence of temporal lobe epilepsy in rats.
Topics: Animals; Axon Initial Segment; Behavior, Animal; Cell Proliferation; Chronic Disease; Dendrites; Den | 2017 |
Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique.
Topics: Algorithms; Animals; Electroencephalography; Epilepsy, Temporal Lobe; Mice; Pilocarpine; Seizures | 2017 |
Altered intrinsic functional connectivity in the latent period of epileptogenesis in a temporal lobe epilepsy model.
Topics: Animals; Brain Mapping; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Tempo | 2017 |
Effects of acute physical exercise in the light phase of sleep in rats with temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrocorticography; Electrodes, Implanted; Epilepsy, Tempo | 2017 |
Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Mal | 2017 |
Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Disease Models, Animal; Epilepsy, Tempora | 2018 |
Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Metformin; Pilocarp | 2018 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administrati | 2017 |
Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation.
Topics: Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Postsynaptic P | 2017 |
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP | 2018 |
New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy.
Topics: Animals; Caspase 3; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intrav | 2018 |
The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2018 |
A novel online fluorescence method for in-vivo measurement of hydrogen peroxide during oxidative stress produced in a temporal lobe epilepsy model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hydrogen Peroxide; | 2018 |
Dysregulated long non-coding RNAs in the temporal lobe epilepsy mouse model.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling | 2018 |
Notch Signaling Regulates Microglial Activation and Inflammatory Reactions in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Inflammation; Inflammation Mediators; Male; Microglia; Pilocarpine | 2018 |
Altered activity and information flow in the default mode network of pilocarpine-induced epilepsy rats.
Topics: Animals; Brain; Brain Waves; Connectome; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2018 |
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Cognition Disorders; Depressive Disorder; Disease Mode | 2018 |
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combi | 2019 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; | 2019 |
Abnormal hippocampal functional network and related memory impairment in pilocarpine-treated rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Hippocampus; Image P | 2018 |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Drug Discovery; Epilepsy; Epi | 2018 |
[Targeting diagnosis and treatment value of chelating anti-IL-1β mAb-SPIONs in temporal lobe epilepsy model].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; Pilocarpin | 2018 |
SLC1A2 mediates refractory temporal lobe epilepsy with an initial precipitating injury by targeting the glutamatergic synapse pathway.
Topics: Animals; Astrocytes; Biomarkers; Cell Death; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transpor | 2019 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2019 |
Gene Expression Profiling of Two Epilepsy Models Reveals the ECM/Integrin signaling Pathway is Involved in Epiletogenesis.
Topics: Animals; Databases, Genetic; Epilepsy, Temporal Lobe; Extracellular Matrix Proteins; Gene Expression | 2019 |
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem | 2019 |
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cannabidiol; Disease Models, Animal; Epilepsy; Epilepsy, | 2019 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Tempor | 2019 |
(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.
Topics: Animals; Catechin; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; | 2019 |
Increased expression of DOC2A in human and rat temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Calcium-Binding Proteins; Disease Models, Animal; Epilepsy, Temporal Lob | 2019 |
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe | 2019 |
Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice.
Topics: Animals; Anxiety; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; GABAergic Neur | 2019 |
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Inflammasomes; Inflammation; Leucine; Male; Mice; Mice | 2019 |
Neuroprotective effects of lovastatin in the pilocarpine rat model of epilepsy according to the expression of neurotrophic factors.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Ciliary Neurotrophic Factor; Disease Models, | 2019 |
Subchronic cerebrolysin treatment alleviates cognitive impairments and dendritic arborization alterations of granular neurons in the hippocampal dentate gyrus of rats with temporal lobe epilepsy.
Topics: Amino Acids; Animals; Cognition; Cognitive Dysfunction; Dentate Gyrus; Epilepsy, Temporal Lobe; Hipp | 2019 |
Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognition; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Explorat | 2019 |
Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.
Topics: Animals; Boron Compounds; Disease Models, Animal; Drug Delivery Systems; Epilepsy, Temporal Lobe; Fl | 2019 |
Ameliorating impacts of ginseng on the apoptosis of spermatogenic cells and sperm quality in temporal lobe epilepsy rat model treated with valproate.
Topics: Animals; Anticonvulsants; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Infert | 2019 |
Upregulation of hippocampal synaptophysin, GFAP and mGluR3 in a pilocarpine rat model of epilepsy with history of prolonged febrile seizure.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Prote | 2019 |
Targeting Seizure-Induced Neurogenesis in a Clinically Relevant Time Period Leads to Transient But Not Persistent Seizure Reduction.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Neural Stem Cells; Neu | 2019 |
Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction.
Topics: Animals; Cognitive Dysfunction; Dentate Gyrus; Epilepsy, Temporal Lobe; Female; Male; Mice, Inbred C | 2019 |
MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Mapping; Calcium-Binding Proteins; Complement C3; Diffusion Magnetic Resonance | 2014 |
Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats.
Topics: Adolescent; Adult; Animals; Axons; Case-Control Studies; Cytoplasm; Epilepsy, Temporal Lobe; Female; | 2013 |
Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a study on patients and pilocarpine-induced rats.
Topics: Animals; Astrocytes; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; | 2013 |
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; C | 2013 |
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice.
Topics: Amino Acids; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy, | 2013 |
Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy.
Topics: Adolescent; Animals; Astrocytes; Case-Control Studies; Child; Epilepsy, Temporal Lobe; Female; Hippo | 2013 |
Association of mitochondrial letm1 with epileptic seizures.
Topics: Adolescent; Adult; Animals; Brain; Calcium-Binding Proteins; Cation Transport Proteins; Child; Epile | 2014 |
Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Epilepsy, Temporal Lobe; Indoles; Male; Neuroprotective Agents; Oxindoles | 2013 |
Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation.
Topics: Animals; Blotting, Western; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, T | 2013 |
[Morphology and differentially expressed proteins in hippocampus of mesial temporal lobe epilepsy model of immature rats induced by pilocarpine].
Topics: Animals; Epilepsy, Temporal Lobe; Female; Hippocampus; Male; Pilocarpine; Proteins; Proteomics; Rats | 2013 |
Speed modulation of hippocampal theta frequency correlates with spatial memory performance.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2013 |
High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Mossy Fibers, H | 2013 |
Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy.
Topics: Animals; Behavior, Animal; Brain Mapping; Creatine; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2013 |
Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.
Topics: Allosteric Regulation; Animals; Binding Sites; Cognition Disorders; D-Amino-Acid Oxidase; Disease Mo | 2013 |
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Dipeptides; Disease Models, Animal; Electric Stimulation; Epil | 2013 |
Validation of suitable reference genes for expression studies in different pilocarpine-induced models of mesial temporal lobe epilepsy.
Topics: Animals; Computational Biology; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Reg | 2013 |
Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Electroencephalography; Epilepsy, Temporal Lobe; E | 2013 |
Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Animals; Case-Control Studies; Child; | 2014 |
Decreased expression of proteins involved in energy metabolism in the hippocampal granular layer of rats submitted to the pilocarpine epilepsy model.
Topics: Animals; Energy Metabolism; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Male; Pilocarpine; Prote | 2014 |
Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Epilepsy, Temporal Lobe; Hippocampus; Mice, Inbred | 2014 |
Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chronic Disease; Disease Models, A | 2014 |
In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease Models, Animal; Epileps | 2014 |
Attention and executive functions in a rat model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Attention; Brain; Brain Mapping; Carbamates; Cell Count; Disease Models, A | 2014 |
Melatonin protects testes against lithium-pilocarpine-induced temporal lobe epilepsy in rats: a time course study.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Male; Melatonin; Piloc | 2015 |
Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy.
Topics: Animals; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Rats, Spra | 2014 |
Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE).
Topics: Adult; Animals; Anterior Temporal Lobectomy; Disease Models, Animal; Epilepsy, Temporal Lobe; Female | 2014 |
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocam | 2014 |
[Inhibitory effects of epileptic spikes on theta rhythm in rat pilocarpine model of temporal lobe epilepsy].
Topics: Animals; CA1 Region, Hippocampal; Epilepsy, Temporal Lobe; Pilocarpine; Rats; Theta Rhythm | 2014 |
Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Cognition Disorders; Comorbidity; Disease Model | 2014 |
Abnormal metabolic connectivity in the pilocarpine-induced epilepsy rat model: a multiscale network analysis based on persistent homology.
Topics: Algorithms; Animals; Convulsants; Epilepsy, Temporal Lobe; Fluorodeoxyglucose F18; Image Processing, | 2014 |
Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.
Topics: Animals; Calcium Channels; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Molec | 2015 |
Reorganization of supramammillary-hippocampal pathways in the rat pilocarpine model of temporal lobe epilepsy: evidence for axon terminal sprouting.
Topics: Animals; Biotin; Dextrans; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Hypothalamu | 2015 |
Identification of endogenous reference genes for the analysis of microRNA expression in the hippocampus of the pilocarpine-induced model of mesial temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; Hippocampus; Ma | 2014 |
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Topics: Adult; Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Fl | 2014 |
Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Blotting, Western; Brain; Cell Differentiation; Chromatography, High | 2014 |
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Epoxide Hydrolases; Hippocampus; Inflammat | 2015 |
Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Animals; CA3 Region, Hippocampal; Case-Control Studies; Child; Dendrites; Epileps | 2015 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-A | 2014 |
Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mice; Micr | 2015 |
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Dynamin I; Epilepsy, Temporal Lobe; Female | 2015 |
Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Death; Cytidine Diphosphate Choline; Disease Model | 2015 |
Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Cell Survival; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Excit | 2015 |
ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission.
Topics: Action Potentials; Adenosine; Adolescent; Adult; Animals; Anterior Temporal Lobectomy; Anticonvulsan | 2015 |
Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electric Stimulation; | 2015 |
Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2015 |
Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Cortex; Electroencephalography; Encepha | 2015 |
Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.
Topics: Animals; Dendritic Spines; Docosahexaenoic Acids; Epilepsy, Temporal Lobe; Hippocampus; Limbic Syste | 2015 |
The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epi | 2015 |
The role of ubiquitin/Nedd4-2 in the pathogenesis of mesial temporal lobe epilepsy.
Topics: Adenosine Monophosphate; Analysis of Variance; Animals; Animals, Newborn; Antimanic Agents; Cells, C | 2015 |
FDG-PET and NeuN-GFAP immunohistochemistry of hippocampus at different phases of the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Antigens, Nuclear; Brain Mapping; Epilepsy, Temporal Lobe; Fluorodeoxyglucose F18; Glial Fi | 2015 |
Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients.
Topics: Adult; Aged; Animals; Child; Disease Models, Animal; Drug Resistant Epilepsy; Epilepsy, Temporal Lob | 2015 |
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognition Disorders; Disease Models, Animal; | 2015 |
The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus.
Topics: Animals; Axons; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Neurons; Neurope | 2015 |
Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy.
Topics: Action Potentials; Animals; Brain Waves; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2015 |
Ischemic-hypoxic mechanisms leading to hippocampal dysfunction as a consequence of status epilepticus.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Hypoxia, Brai | 2015 |
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Res | 2015 |
Association of Alpha-Soluble NSF Attachment Protein with Epileptic Seizure.
Topics: Adolescent; Adult; Animals; Cerebral Cortex; Child; Down-Regulation; Epilepsy; Epilepsy, Temporal Lo | 2015 |
Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy.
Topics: Animals; Antioxidants; Cell Death; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal L | 2015 |
Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Electrocorticography; Electrodes, Impl | 2015 |
Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epileps | 2015 |
GABAergic inhibition shapes interictal dynamics in awake epileptic mice.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Calcium; Calmodulin; Corpus Striatum; Disease M | 2015 |
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Case-Control Studies; Disease Models, Anim | 2015 |
Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Adolescent; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Humans; | 2015 |
Plic-1, a new target in repressing epileptic seizure by regulation of GABAAR function in patients and a rat model of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Anticonvulsants; Autophagy-Related | 2015 |
Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy.
Topics: Adult; Aged; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; | 2016 |
Protein-caloric dietary restriction inhibits mossy fiber sprouting in the pilocarpine model of TLE without significantly altering seizure phenotype.
Topics: Animals; Caloric Restriction; Diet, Protein-Restricted; Disease Models, Animal; Electroencephalograp | 2015 |
Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Circadian Rhythm; Darkness; Epilepsy, Temporal Lobe; Hippocampus; Male; Pilocarpine; Rats; | 2015 |
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; | 2015 |
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Lithium; | 2016 |
TRPV1 receptors augment basal synaptic transmission in CA1 and CA3 pyramidal neurons in epilepsy.
Topics: Animals; Capsaicin; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potenti | 2016 |
Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Axons; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mossy Fiber | 2016 |
Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.
Topics: Action Potentials; Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fema | 2016 |
Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?
Topics: Angiogenesis Inhibitors; Animals; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippo | 2016 |
Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Male; Maze | 2016 |
CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Topics: Active Transport, Cell Nucleus; Animals; Convulsants; Cyclic AMP Response Element-Binding Protein; D | 2016 |
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2016 |
Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta | 2016 |
Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Disease Models, Animal; Drug Resistant Epilepsy | 2016 |
Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Convulsants; Disease Models, | 2016 |
More Docked Vesicles and Larger Active Zones at Basket Cell-to-Granule Cell Synapses in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Linear Models; Male; Microscopy, Electron, | 2016 |
Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Green Fluorescent Proteins; | 2016 |
Synthesis of N-1', N-3'-disubstituted spirohydantoins and their anticonvulsant activities in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Molecular Struc | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A | 2016 |
Characterization of Intracranial Pressure Behavior in Chronic Epileptic Animals: A Preliminary Study.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Tempor | 2016 |
Altered behavior and neural activity in conspecific cagemates co-housed with mouse models of brain disorders.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Depression; Electroshock; Epilepsy, Temporal Lobe; Ex | 2016 |
Epigenetic Suppression of GADs Expression is Involved in Temporal Lobe Epilepsy and Pilocarpine-Induced Mice Epilepsy.
Topics: Adolescent; Adult; Animals; Epigenesis, Genetic; Epilepsy, Temporal Lobe; Female; Gene Expression Re | 2016 |
Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model.
Topics: Adenylate Kinase; Adolescent; Adult; Animals; Brain Injuries, Traumatic; Carrier Proteins; Child; Di | 2016 |
The pilocarpine model of temporal lobe epilepsy: Marked intrastrain differences in female Sprague-Dawley rats and the effect of estrous cycle.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2016 |
Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Levetiraceta | 2016 |
Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model.
Topics: Adolescent; Adult; Analysis of Variance; Animals; Brain; Calcium-Binding Proteins; Disease Models, A | 2016 |
Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2016 |
Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; Gene Expression | 2016 |
MicroRNA-139-5p negatively regulates NR2A-containing NMDA receptor in the rat pilocarpine model and patients with temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid | 2016 |
Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL/6 mice.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Male; Me | 2016 |
Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents.
Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tempor | 2017 |
Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats.
Topics: Adolescent; Adult; Animals; Biomarkers; Chemokine CXCL13; Child; Epilepsy; Epilepsy, Temporal Lobe; | 2017 |
Hippocampal asymmetry: differences in the left and right hippocampus proteome in the rat model of temporal lobe epilepsy.
Topics: Animals; Dopamine; Electrophoresis, Gel, Two-Dimensional; Epilepsy, Temporal Lobe; Functional Latera | 2017 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal | 2017 |
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Convulsants; Epilepsy, Temporal Lobe; Gene Kno | 2017 |
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Electrocorticography; Electromyography; Epileps | 2016 |
Epilepsy and exercise: An experimental study in female rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Estrous Cycle; Femal | 2017 |
Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus.
Topics: Animals; Anxiety; Epilepsy, Temporal Lobe; Fear; Male; Pilocarpine; Pyrroles; Quinazolines; Rats; Ra | 2017 |
HMGB1-TLR4 Axis Plays a Regulatory Role in the Pathogenesis of Mesial Temporal Lobe Epilepsy in Immature Rat Model and Children via the p38MAPK Signaling Pathway.
Topics: Animals; Animals, Newborn; Cells, Cultured; Child; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Femal | 2017 |
Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis.
Topics: Animals; Cerebral Cortex; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; I | 2018 |
A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Calpain; Cerebral Cortex; Dipeptides; Disease Models, Animal; Dose-Respons | 2017 |
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Topics: Adolescent; Adult; Animals; Child; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; | 2017 |
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lo | 2017 |
Expression of vitamin D receptor mRNA in the hippocampal formation of rats submitted to a model of temporal lobe epilepsy induced by pilocarpine.
Topics: Animals; Behavior, Animal; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Male; Musc | 2008 |
Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.
Topics: Animals; Behavior, Animal; Depression; Epilepsy, Temporal Lobe; Fluoxetine; Hippocampus; Lithium Chl | 2008 |
Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Topics: Animals; Blotting, Western; Calcineurin Inhibitors; Calcium Channel Blockers; Calcium Channels, L-Ty | 2009 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy.
Topics: Animals; Biomarkers; Cell Count; Convulsants; Disease Models, Animal; Enzyme Activation; Epilepsy; E | 2008 |
Thalamic pathology in sudden cardiac death in epilepsy: a shed light on mysterious event.
Topics: Animals; Brain; Death, Sudden, Cardiac; Disease Models, Animal; Epilepsy, Temporal Lobe; Heart Arres | 2008 |
Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy, Tem | 2008 |
Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Epilepsy, Temporal Lobe; Gene Expres | 2008 |
Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calbindin 2; Cell Death; Cholera Toxin; Disease Models, Animal; DNA-Binding Proteins; Elect | 2009 |
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.
Topics: Animals; Calcium Channels, T-Type; Calcium Signaling; Channelopathies; Disease Models, Animal; Epile | 2008 |
Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regu | 2009 |
Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats.
Topics: Animals; Brain; Epilepsy, Temporal Lobe; Estrogens, Conjugated (USP); Female; Muscarinic Agonists; P | 2009 |
h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Elec | 2009 |
Upregulated TWIK-related acid-sensitive K+ channel-2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Atropine Derivatives; Cerebral Ventricles; Disease Models, Animal; Epilepsy, Te | 2009 |
[Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats].
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Neuropeptide Y; Pilocarpine; Rand | 2009 |
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted | 2009 |
Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Calbindin 2; Calbindins; Data Interpretation, Statistical; Dendrites; Den | 2010 |
Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Progression; Dose-Response Re | 2009 |
Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Male; Memory; Memory Disorders; Pilocarpine; Rats; Rats, Wistar; S | 2009 |
Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Disease Susceptibility; Epilepsy, Temporal Lobe; Female; Glu | 2009 |
In vivo mapping of temporospatial changes in glucose utilization in rat brain during epileptogenesis: an 18F-fluorodeoxyglucose-small animal positron emission tomography study.
Topics: Animals; Brain; Epilepsy, Temporal Lobe; Fluorodeoxyglucose F18; Glucose; Male; Pilocarpine; Positro | 2009 |
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Animals; Anxiety Disorders; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Epileps | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Does pilocarpine-induced epilepsy in adult rats require status epilepticus?
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Inflammatio | 2009 |
Behavioral and histological assessment of the effect of intermittent feeding in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Eating; Epileps | 2009 |
Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Atropine Derivatives; Dentate Gyrus; Disease Models, Animal; Electric | 2009 |
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Atropine Derivatives; Axons; Dentate Gyrus; Disease Models, Animal; Epilep | 2009 |
Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus.
Topics: Animals; Blotting, Western; Cell Count; Electroencephalography; Electrophysiology; Entorhinal Cortex | 2009 |
In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Benzamides; Brain; Brain Mapping; Corpus Striatum; Disease Models, Animal; | 2010 |
Behavioural and histological effects of preconditioning with lipopolysaccharide in epileptic rats.
Topics: Animals; Behavior, Animal; Epilepsy, Temporal Lobe; Hippocampus; Ischemic Preconditioning; Lipopolys | 2010 |
Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Cell Size; Cell Survival; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal | 2009 |
Pitfalls of high-pass filtering for detecting epileptic oscillations: a technical note on "false" ripples.
Topics: Algorithms; Animals; Artifacts; Biological Clocks; Brain Mapping; Convulsants; Disease Models, Anima | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; F | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies.
Topics: Animals; Epilepsy, Temporal Lobe; Muscarinic Agonists; Oxygen Consumption; Physical Conditioning, An | 2009 |
The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temp | 2010 |
Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Electrophysiology; Epilepsy, Temporal Lobe; Fluoresceins; Fluorescent | 2010 |
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Dentate Gyr | 2010 |
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Cerebral Cortex; Cyclooxygenase 2; Cyclooxyge | 2010 |
Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Post | 2010 |
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiology; Ep | 2010 |
Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 2010 |
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Arachidonic Acids; Blotting, Western; Cannabinoids; Dentate Gyrus; Disea | 2010 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; | 2010 |
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2010 |
Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity.
Topics: Adolescent; Adult; Albumins; Animals; Blood-Brain Barrier; Child, Preschool; Disease Models, Animal; | 2010 |
Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.
Topics: Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; H | 2010 |
Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
Topics: Animals; Convulsants; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocam | 2010 |
Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats.
Topics: Animals; Anticonvulsants; Caloric Restriction; Cerebral Cortex; Diet, Ketogenic; Dietary Carbohydrat | 2010 |
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Death; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male | 2010 |
Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy.
Topics: Alternative Splicing; Animals; Calcium; Dentate Gyrus; Epilepsy, Temporal Lobe; Exons; Large-Conduct | 2011 |
Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitato | 2011 |
Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus.
Topics: Animals; Epilepsy, Temporal Lobe; Gastric Inhibitory Polypeptide; Hippocampus; Humans; Immunohistoch | 2011 |
Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Epil | 2010 |
High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Electroencephalography; Epilepsy, Temporal Lobe; Pil | 2011 |
Altered expression of Dscam in temporal lobe tissue from human and experimental animals.
Topics: Adolescent; Adult; Animals; Cell Adhesion Molecules; Child; Disease Models, Animal; Epilepsy, Tempor | 2011 |
Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model.
Topics: Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Poten | 2011 |
Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cell Shape; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2011 |
Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoxazines; Callithrix; Diazepam; Disease Models, | 2011 |
Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Blood Glucose; Disease Models, Animal; Epilepsy, | 2011 |
Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Cytoskeletal Proteins; Disease Mod | 2011 |
Improvement of the pilocarpine epilepsy model in rat using bone marrow stromal cell therapy.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lo | 2011 |
Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity.
Topics: Action Potentials; Amphetamine; Analysis of Variance; Animals; Disease Models, Animal; Dopamine Agen | 2012 |
[Neuronal synaptic reconstruction in hippocampus in chronic phase of pilocarpine-treated rats].
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Male; Neuropeptide Y; Pilocarpine; Rats; Rats, Spragu | 2011 |
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats.
Topics: Animals; Astrocytes; Blood Vessels; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cell Count; Ep | 2011 |
An experimental study on dynamic morphological changes and expression pattern of GFAP and synapsin i in the hippocampus of MTLE models for immature rats.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Express | 2011 |
Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lo | 2011 |
Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model.
Topics: Adolescent; Adult; Animals; Apelin; Blotting, Western; Brain; Case-Control Studies; Child; Disease M | 2011 |
Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Convulsants; Disease Models, Animal; Disease Pr | 2011 |
Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Green Fluore | 2011 |
Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Hipp | 2012 |
Malnutrition in infancy as a susceptibility factor for temporal lobe epilepsy in adulthood induced by the pilocarpine experimental model.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus | 2011 |
Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.
Topics: Abdominal Fat; Analysis of Variance; Animals; Chronic Disease; Disease Models, Animal; Energy Metabo | 2011 |
Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Electrophysiology; Epilepsy, Temporal Lobe; Hippocampus; Im | 2011 |
Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?
Topics: Animals; Critical Period, Psychological; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2011 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2012 |
Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Epilepsy, Temporal Lobe; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; | 2012 |
[Axonal sprouting of somatostatin positive interneurons in the hippocampus in epileptic rats].
Topics: Animals; Axons; CA1 Region, Hippocampal; Efferent Pathways; Epilepsy, Temporal Lobe; Interneurons; M | 2011 |
Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulati | 2012 |
BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.
Topics: Amygdala; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; CA3 Re | 2012 |
Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.
Topics: Adolescent; Adult; Animals; Carrier Proteins; Disease Models, Animal; Dysbindin; Dystrophin-Associat | 2012 |
Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Convulsants; Dentate Gyrus; Electrophysiologica | 2012 |
Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship | 2012 |
Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Topics: Animals; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Dentate Gyrus; Disease Models, An | 2012 |
A new trick of INPP4A: decreased expression of INPP4A in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Topics: Adolescent; Adult; Animals; Down-Regulation; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; M | 2012 |
Variations in elemental compositions of rat hippocampal formation between acute and latent phases of pilocarpine-induced epilepsy: an X-ray fluorescence microscopy study.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Metals; Microscopy, Fluorescence; Muscarinic Agonists | 2012 |
The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Topics: Animals; Base Sequence; DNA Primers; Epilepsy, Temporal Lobe; Hippocampus; Male; Pilocarpine; Rats; | 2012 |
Involvement of 5-HT₇ receptors in the pathogenesis of temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Behavior, Animal; Child; Disease Models, Animal; Electroencephalography; | 2012 |
New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction.
Topics: Animals; Animals, Newborn; Cytoplasmic Granules; Dentate Gyrus; Doublecortin Domain Proteins; Epilep | 2012 |
Impairment of sexual function in rats with epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Muscarinic Agonists; Pilocarpine; Ra | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agoni | 2012 |
Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Animals, Newborn; Child; Disease Models, Animal; Epilepsy, Temporal L | 2012 |
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.
Topics: Age Factors; Animals; Anticonvulsants; Atropine; Body Weight; Diazepam; Disease Models, Animal; Epil | 2012 |
Diversity and excitability of deep-layer entorhinal cortical neurons in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Dendrites; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal | 2012 |
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.
Topics: Animals; Anticholesteremic Agents; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electro | 2012 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Ep | 2013 |
Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2012 |
MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cell Death; Computational Biology; Disease Mode | 2012 |
Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Microscopy, Fluorescenc | 2012 |
Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy.
Topics: Animals; Convulsants; Dentate Gyrus; Epilepsy, Temporal Lobe; Long-Term Synaptic Depression; Male; M | 2013 |
Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; As | 2012 |
Early deficits in social behavior and cortical rhythms in pilocarpine-induced mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2013 |
Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety?
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Cell Death; Disease Models, Animal; Dose-Res | 2013 |
Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.
Topics: Animals; Ephrin-A4; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Male; Mice; Pi | 2013 |
Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Tra | 2013 |
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy.
Topics: Animals; Biomarkers; C-Reactive Protein; Electroencephalography; Enzyme-Linked Immunosorbent Assay; | 2013 |
Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Te | 2002 |
Damage, reorganization, and abnormal neocortical hyperexcitability in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Electrophysiology; Epilepsy, Temporal Lobe; Immunohistochemistry; Male; Neocor | 2002 |
Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calc | 2002 |
Evidence that ATP participates in the pathophysiology of pilocarpine-induced temporal lobe epilepsy: fluorimetric, immunohistochemical, and Western blot studies.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Convulsants; Epilepsy, Temporal Lobe; Fluorometr | 2002 |
Relations between brain pathology and temporal lobe epilepsy.
Topics: Animals; Brain; Cell Death; Cell Survival; Chronic Disease; Disease Models, Animal; Disease Progress | 2002 |
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.
Topics: Animals; Atropine Derivatives; Axons; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Fe | 2002 |
Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Calcium Signaling; Cell Membrane; Dia | 2002 |
Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: neuronal damage and immunocytochemical changes in chronic epileptic rats.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Neocortex; Ne | 2002 |
Reassessment of the effects of cycloheximide on mossy fiber sprouting and epileptogenesis in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Cycloheximide; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Mal | 2002 |
Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model.
Topics: Age Factors; Animals; Brain Diseases; Cerebral Cortex; Disease Models, Animal; Entorhinal Cortex; Ep | 2002 |
Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine Vaso | 2002 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe | 2003 |
Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Atropine Derivatives; Cell Count; Dentate Gyrus; Disease Models, Animal; | 2003 |
Development of temporal lobe epilepsy in 21-day-old rats.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Magnetic Reso | 2003 |
Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Death; Cerebral Cortex; Convulsants; Electroenceph | 2003 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
[Temporal lobe epilepsy model induced by pilocarpine in rats].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Rats, Sprague-Daw | 2003 |
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Disease Models, Animal; Endocannabinoids; | 2003 |
Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; gamma-Am | 2003 |
Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures.
Topics: Animals; Calcium-Binding Proteins; Calponins; Dendrites; Dentate Gyrus; Disease Models, Animal; Epil | 2003 |
Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cell Count; Creatine; Diazepam; Disease Models, Animal; Epi | 2003 |
Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Kindli | 2003 |
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy.
Topics: Animals; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Hippoca | 2003 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippoca | 2004 |
Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats.
Topics: Animals; Cell Count; Dentate Gyrus; Electroencephalography; Epilepsy, Temporal Lobe; Immunohistochem | 2004 |
Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excit | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cone | 2004 |
Elevated nociceptive thresholds in rats with multifocal brain damage induced with single subcutaneous injections of lithium and pilocarpine.
Topics: Acepromazine; Animals; Antipsychotic Agents; Brain Injuries; Epilepsy, Temporal Lobe; Female; Inject | 2004 |
Neuroscience. Epileptic neurons go wireless.
Topics: Action Potentials; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Feedback, Physiological; Hipp | 2004 |
Acquired dendritic channelopathy in temporal lobe epilepsy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Butadien | 2004 |
Neuronal and glial cell populations in the piriform cortex distinguished by using an approximation of q-space imaging after status epilepticus.
Topics: Amygdala; Animals; Cell Death; Convulsants; Diffusion Magnetic Resonance Imaging; Disease Models, An | 2004 |
Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Densitometry; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Epilepsy, | 2004 |
Carbamazepine enhances discriminative memory in a rat model of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Discrimination Learning; Disease Models, Animal; Drug Ad | 2004 |
Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Interleuki | 2004 |
Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hi | 2005 |
Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Bicuculline; Cell Count; Dendrites; Dendritic Spines; Disease Models, Animal; Epilepsy, Tem | 2005 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Cell Count; Disease Models, Animal; Entorhinal Cortex; Epilepsy, | 2005 |
Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Denervation; Disease Models, Animal; Epilepsy, Temporal Lobe; H | 2005 |
The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2005 |
Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans.
Topics: Adult; Animals; Chronic Disease; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Fluorescent | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2005 |
Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats.
Topics: Animals; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus | 2005 |
Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Topics: Animals; Cycloheximide; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
[Mossy fiber sprouting and synapse formation in the dentate gyrus of temporal lobe epilepsy rats induced by pilocarpine].
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; GAP-43 Protein; Male; Mossy Fibers, Hippocampal; Pi | 2004 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy.
Topics: Adult; Animals; Antimetabolites; Biomarkers; Bromodeoxyuridine; Cell Differentiation; Cell Movement; | 2006 |
Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Long-Term Pote | 2006 |
Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Electron Transport Com | 2006 |
Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Cell Count; Conditioning, Psychological; C | 2005 |
Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Disease Models, Animal; | 2006 |
Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Cholera Toxin; Choline O-Acetyltransferase; Disease Mo | 2006 |
Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, T | 2005 |
Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Bicuculline; Chelating Agents; Disease Models, Animal; Drug Interactions | 2006 |
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
Topics: Animals; Brain; Cell Death; Cerebral Cortex; eIF-2 Kinase; Epilepsy, Temporal Lobe; Hippocampus; Mic | 2006 |
Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brai | 2006 |
EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Chemistry; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 3; Fluor | 2006 |
Septo-hippocampal networks in chronically epileptic rats: potential antiepileptic effects of theta rhythm generation.
Topics: Action Potentials; Animals; Anticonvulsants; Biological Clocks; Chronic Disease; Drug Delivery Syste | 2006 |
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Te | 2006 |
Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Benzoquinones; Cell Count; Cell Death; Disease Models, Animal; Drug A | 2006 |
Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Cholesterol Side-Chain | 2006 |
Abnormal mGluR2/3 expression in the perforant path termination zones and mossy fibers of chronically epileptic rats.
Topics: Animals; Chronic Disease; Dentate Gyrus; Down-Regulation; Epilepsy, Temporal Lobe; Fluorescent Antib | 2006 |
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Convulsants; Dentate Gyrus; Disease Models, A | 2006 |
Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Biomarkers; Convulsants; Disease Models, Animal; Electric Stimulation; E | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph | 2006 |
Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy.
Topics: Action Potentials; Animals; Axons; Cerebral Cortex; Convulsants; Dentate Gyrus; Disease Models, Anim | 2006 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model.
Topics: Animals; Carrier Proteins; Data Interpretation, Statistical; DNA Primers; DNA, Complementary; Epilep | 2007 |
Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsy.
Topics: Animals; Biotin; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Membrane Potentials; Musc | 2007 |
Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitato | 2007 |
Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.
Topics: Animals; Cell Count; Cell Survival; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Glu | 2007 |
Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzoates; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationsh | 2007 |
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Male; Muscarinic Agonist | 2007 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Ge | 2007 |
[Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy].
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; In Situ Hybridization; Lithium C | 2007 |
Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting.
Topics: Algorithms; Animals; Anticonvulsants; Cell Count; Cell Shape; Dentate Gyrus; Epilepsy, Temporal Lobe | 2007 |
Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study.
Topics: Action Potentials; Animals; Cell Death; Convulsants; Cortical Synchronization; Disease Models, Anima | 2007 |
Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Image | 2007 |
Doublecortin-positive newly born granule cells of hippocampus have abnormal apical dendritic morphology in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Epil | 2007 |
Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleat | 2007 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Count; Disease Models, Animal; Electroencephalography; Epi | 2008 |
Cytoarchitectonics and afferent/efferent reorganization of neurons in layers II and III of the lateral entorhinal cortex in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Fluorescent Antibody Te | 2008 |
GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.
Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Neurons; | 2007 |
Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy.
Topics: Amino Acid Sequence; Animals; Epilepsy, Temporal Lobe; Gene Regulatory Networks; Hippocampus; Immuno | 2008 |
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Disease Models, Animal; Encephalitis; Epilepsy, Tempo | 2008 |
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chronic Disease; Convulsants; Disease Models, Animal; Down- | 2008 |
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capill | 2008 |
Temporal lobe epilepsy and social behavior: an animal model for autism?
Topics: Animals; Autistic Disorder; Behavior, Animal; Discrimination, Psychological; Disease Models, Animal; | 2008 |
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Convulsants; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2008 |
[The effect of low frequency transcranial magnetic stimulation on neuropeptide-Y expression and apoptosis of hippocampus neurons in epilepsy rats induced by pilocarpine].
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Neurons; Neu | 2007 |
Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy.
Topics: Animals; Biomarkers; Dendrites; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric | 2008 |
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal L | 1995 |
Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy.
Topics: Animals; Antibodies; Axons; Cholinergic Fibers; Epilepsy, Temporal Lobe; Male; Nerve Fibers; Nerve G | 1995 |
Decrement of GABAA receptor-mediated inhibitory postsynaptic currents in dentate granule cells in epileptic hippocampus.
Topics: Animals; Dentate Gyrus; Electrophysiology; Epilepsy, Temporal Lobe; Hippocampus; Humans; In Vitro Te | 1996 |
Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Ki | 1996 |
The pilocarpine model of epilepsy in mice.
Topics: Animals; Coloring Agents; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; E | 1996 |
Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats.
Topics: Animals; Cerebral Cortex; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Male; Neuronal | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Male; Neural Pathways; Pil | 1997 |
Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons.
Topics: Animals; Clonazepam; Epilepsy, Temporal Lobe; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampu | 1997 |
Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Cell Count; Epilepsy, Temporal Lobe; Immunohistochemistry; Interneurons; Male; Musca | 1997 |
Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Ra | 1997 |
Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats.
Topics: Animals; Barium; Epilepsy, Temporal Lobe; Extracellular Space; Hippocampus; In Vitro Techniques; Mal | 1998 |
GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric | 1998 |
Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy.
Topics: Animals; Cell Separation; Dentate Gyrus; Electric Conductivity; Epilepsy, Temporal Lobe; Gene Expres | 1998 |
Modulation of GABAA receptor-mediated inhibition by postsynaptic calcium in epileptic hippocampal neurons.
Topics: Animals; Calcium; Chelating Agents; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Hippoca | 1998 |
Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Ionto | 1998 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Elect | 1999 |
GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Immunoenzyme | 1999 |
Loss of NADPH diaphorase-positive neurons in the hippocampal formation of chronic pilocarpine-epileptic rats.
Topics: Animals; Biomarkers; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epil | 1999 |
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression R | 1999 |
Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy.
Topics: Animals; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Amino | 1999 |
Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult Rat.
Topics: Age Factors; Animals; Behavior, Animal; Benzoxazines; Brain Stem; Carbon Radioisotopes; Cell Death; | 2000 |
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Apyrase; Epilepsy, Temporal Lobe; Excitatory Am | 2000 |
Ultrastructural identification of dentate granule cell death from pilocarpine-induced seizures.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Human | 2000 |
Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy.
Topics: Animals; Electroshock; Epilepsy, Temporal Lobe; Genes, fos; Hippocampus; Long-Term Potentiation; Mal | 2000 |
Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Lipid Pe | 2000 |
Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Lysine; Male; Mo | 2000 |
The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice.
Topics: Animals; Calbindin 2; Cell Death; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2000 |
Alterations of glial cell function in temporal lobe epilepsy.
Topics: Animals; Barium; Epilepsy, Temporal Lobe; Extracellular Space; Hippocampus; Humans; In Vitro Techniq | 2000 |
Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; Hippocampus; Humans; Neu | 2000 |
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2000 |
Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.
Topics: Animals; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Micr | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyru | 2001 |
Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Disease Models, Animal; Disease Progression; | 2001 |
Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Calcium; Calcium Channel Blockers; | 2001 |
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; | 2001 |
Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells.
Topics: Action Potentials; Animals; Biotin; Cell Size; Cell Survival; Cortical Synchronization; Dendrites; E | 2001 |
Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Syne | 2001 |
Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity.
Topics: Action Potentials; Animals; Axons; Dendrites; Dentate Gyrus; Disease Models, Animal; Electric Stimul | 2001 |
Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium; Neuro | 2001 |
Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus.
Topics: Animals; Annexins; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxyuridine; Caenorhabditis e | 2001 |
Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.
Topics: Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Ago | 2001 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; | 2001 |
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Antimanic Agents; Electroencephalography; Epilepsy, Temporal Lobe; Glutama | 2001 |
Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2002 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats.
Topics: Animals; Behavior, Animal; Brain; Cell Count; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Prote | 2002 |
Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Infusion Pumps; Levetiracetam; Muscarinic | 2002 |
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; E | 2002 |
Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy.
Topics: Animals; Cell Count; Cytoplasmic Granules; Electroencephalography; Epilepsy, Temporal Lobe; Hippocam | 1992 |
Susceptibility to pilocarpine-induced seizures in rats increases with age.
Topics: Acetylcholine; Age Factors; Animals; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Limb | 1988 |