pilocarpine has been researched along with Epilepsies, Partial in 14 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression." | 5.30 | Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus." | 3.68 | GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures. ( Cavalheiro, EA, 1990) |
| "Interictal activity and seizures are the hallmarks of focal epileptic disorders (which include mesial temporal lobe epilepsy, MTLE) in humans and in animal models." | 3.01 | Evolution of interictal activity in models of mesial temporal lobe epilepsy. ( Avoli, M; Lévesque, M; Macey-Dare, ADB; Salami, P; Wang, S, 2023) |
| " hM4Di has no effect in the absence of its selective, normally inactive and orally bioavailable agonist clozapine-N-oxide (CNO)." | 1.40 | Chemical-genetic attenuation of focal neocortical seizures. ( Kätzel, D; Kullmann, DM; Nicholson, E; Schorge, S; Walker, MC, 2014) |
| "Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression." | 1.30 | Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Lévesque, M | 1 |
| Wang, S | 1 |
| Macey-Dare, ADB | 1 |
| Salami, P | 1 |
| Avoli, M | 1 |
| Yi, PL | 2 |
| Lu, CY | 2 |
| Cheng, CH | 1 |
| Tsai, YF | 1 |
| Lin, CT | 1 |
| Chang, FC | 2 |
| Kätzel, D | 1 |
| Nicholson, E | 1 |
| Schorge, S | 1 |
| Walker, MC | 1 |
| Kullmann, DM | 1 |
| Jou, SB | 1 |
| Trindade-Filho, EM | 1 |
| de Castro-Neto, EF | 1 |
| de A Carvalho, R | 1 |
| Lima, E | 1 |
| Scorza, FA | 1 |
| Amado, D | 1 |
| Naffah-Mazzacoratti, Mda G | 1 |
| Cavalheiro, EA | 4 |
| Xia, Y | 1 |
| Lai, Y | 1 |
| Lei, L | 1 |
| Liu, Y | 1 |
| Yao, D | 1 |
| Kohane, DS | 1 |
| Holmes, GL | 1 |
| Chau, Y | 1 |
| Zurakowski, D | 1 |
| Langer, R | 1 |
| Cha, BH | 1 |
| Meurs, A | 1 |
| Clinckers, R | 1 |
| Ebinger, G | 2 |
| Michotte, Y | 2 |
| Smolders, I | 2 |
| Milh, M | 1 |
| Becq, H | 1 |
| Villeneuve, N | 1 |
| Ben-Ari, Y | 1 |
| Aniksztejn, L | 1 |
| Naffah-Mazzacoratti, MG | 1 |
| Funke, MG | 1 |
| Sanabria, ER | 1 |
| Lindekens, H | 1 |
| Khan, GM | 1 |
| Bialer, M | 1 |
| Fernandes, MJ | 1 |
| Turski, L | 1 |
| Mazzacoratti, MG | 1 |
| Fine, A | 1 |
| Meldrum, BS | 1 |
| Patel, S | 1 |
1 review available for pilocarpine and Epilepsies, Partial
| Article | Year |
|---|---|
Evolution of interictal activity in models of mesial temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pil | 2023 |
13 other studies available for pilocarpine and Epilepsies, Partial
| Article | Year |
|---|---|
Amygdala opioid receptors mediate the electroacupuncture-induced deterioration of sleep disruptions in epilepsy rats.
Topics: Amygdala; Animals; Electroacupuncture; Epilepsies, Partial; Male; Naloxone; Narcotic Antagonists; Pi | 2013 |
Chemical-genetic attenuation of focal neocortical seizures.
Topics: Acute Disease; Animals; Clozapine; Epilepsies, Partial; Gene Silencing; Genetic Therapy; Humans; Mal | 2014 |
Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
Topics: Animals; Electroacupuncture; Electroencephalography; Epilepsies, Partial; Humans; Naloxone; Pilocarp | 2015 |
Serotonin depletion effects on the pilocarpine model of epilepsy.
Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, | 2008 |
Left hemisphere predominance of pilocarpine-induced rat epileptiform discharges.
Topics: Animals; Azides; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Functional Laterality | 2009 |
Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures.
Topics: Animals; Anticonvulsants; Drug Carriers; Drug Implants; Epilepsies, Partial; GABA-A Receptor Agonist | 2002 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response | 2006 |
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease | 2007 |
Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats.
Topics: Animals; Dentate Gyrus; Epilepsies, Partial; GAP-43 Protein; Immunohistochemistry; Male; Phosphoprot | 1999 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; | 2000 |
Neurochemical changes in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Amino Acids; Animals; Dopamine; Electroencephalography; Epilepsies, Partial; Hippocampus; Male; Moto | 1992 |
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; N | 1990 |
Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons.
Topics: Animals; Brain Mapping; Caudate Nucleus; Epilepsies, Partial; Fetus; Kindling, Neurologic; Male; Ner | 1990 |