pilocarpine has been researched along with Encephalitis in 14 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Encephalitis: Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 7.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 5.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 5.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| " Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1β, IL-18, IL-6, and TNF-α) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE." | 3.96 | Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. ( He, J; Liu, S; Shen, K; Wei, Y; Wu, K; Yang, H; Yang, X; Yue, J; Zhang, C, 2020) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 3.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| " Induction of status epilepticus (SE) by Li-pilocarpine was performed on groups G2-G7." | 3.83 | The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats. ( Al Ghamdi, S; ALrefai, AA; Alshareef, A; Bin Sef, B; Borham, LE; Ibrahim, IAA; Khan, M; Labib, AA; Mahfoz, AM; Milibary, A; Shahzad, N, 2016) |
| " Inflammation, angiogenesis and BBB permeability were studied in postnatal day (PN)9 and PN21 rats, 1 week and 4 months after pilocarpine-induced status epilepticus." | 3.75 | Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis. ( Balosso, S; Gagliardi, B; Lerner-Natoli, M; Marcon, J; Maroso, M; Morin, M; Noé, F; Ravizza, T; Vezzani, A, 2009) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 1.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 1.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα)." | 1.42 | Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats. ( Amorim, BO; Brito, JG; Covolan, L; de Morais, DG; deAlmeida, AC; Ferreira, E; Hamani, C; Nobrega, JN; Nunes, DP; Rodrigues, AM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuo, T | 1 |
| Komori, R | 1 |
| Nakatani, M | 1 |
| Ochi, S | 1 |
| Yokota-Nakatsuma, A | 1 |
| Matsumoto, J | 1 |
| Takata, F | 1 |
| Dohgu, S | 1 |
| Ishihara, Y | 1 |
| Itoh, K | 1 |
| Cumbres-Vargas, IM | 1 |
| Zamudio, SR | 1 |
| Pichardo-Macías, LA | 1 |
| Ramírez-San Juan, E | 1 |
| Yue, J | 1 |
| He, J | 1 |
| Wei, Y | 1 |
| Shen, K | 1 |
| Wu, K | 1 |
| Yang, X | 1 |
| Liu, S | 1 |
| Zhang, C | 1 |
| Yang, H | 1 |
| Vizuete, AFK | 1 |
| Hansen, F | 1 |
| Negri, E | 1 |
| Leite, MC | 1 |
| de Oliveira, DL | 1 |
| Gonçalves, CA | 1 |
| Zhu, X | 1 |
| Li, X | 2 |
| Zhu, M | 1 |
| Xu, K | 1 |
| Yang, L | 1 |
| Han, B | 1 |
| Huang, R | 1 |
| Zhang, A | 1 |
| Yao, H | 1 |
| Wang, N | 1 |
| Mi, X | 1 |
| Gao, B | 1 |
| Gu, J | 1 |
| Wang, W | 1 |
| Zhang, Y | 1 |
| Wang, X | 1 |
| Jiang, J | 1 |
| Yang, MS | 1 |
| Quan, Y | 1 |
| Gueorguieva, P | 1 |
| Ganesh, T | 1 |
| Dingledine, R | 2 |
| Amorim, BO | 1 |
| Covolan, L | 1 |
| Ferreira, E | 1 |
| Brito, JG | 1 |
| Nunes, DP | 1 |
| de Morais, DG | 1 |
| Nobrega, JN | 1 |
| Rodrigues, AM | 1 |
| deAlmeida, AC | 1 |
| Hamani, C | 1 |
| Tian, Q | 1 |
| Xiao, Q | 1 |
| Yu, W | 1 |
| Gu, M | 1 |
| Zhao, N | 1 |
| Lü, Y | 1 |
| Borham, LE | 1 |
| Mahfoz, AM | 1 |
| Ibrahim, IAA | 1 |
| Shahzad, N | 1 |
| ALrefai, AA | 1 |
| Labib, AA | 1 |
| Bin Sef, B | 1 |
| Alshareef, A | 1 |
| Khan, M | 1 |
| Milibary, A | 1 |
| Al Ghamdi, S | 1 |
| Marcon, J | 1 |
| Gagliardi, B | 1 |
| Balosso, S | 1 |
| Maroso, M | 1 |
| Noé, F | 1 |
| Morin, M | 1 |
| Lerner-Natoli, M | 1 |
| Vezzani, A | 1 |
| Ravizza, T | 1 |
| Serrano, GE | 1 |
| Lelutiu, N | 1 |
| Rojas, A | 1 |
| Cochi, S | 1 |
| Shaw, R | 1 |
| Makinson, CD | 1 |
| Wang, D | 1 |
| FitzGerald, GA | 1 |
| Gao, F | 1 |
| Liu, Y | 1 |
| Wang, Y | 1 |
| Wei, D | 1 |
| Jiang, W | 1 |
| Shapiro, LA | 1 |
| Wang, L | 1 |
| Ribak, CE | 1 |
14 other studies available for pilocarpine and Encephalitis
| Article | Year |
|---|---|
Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Topics: Animals; Anticonvulsants; Cytokines; Disease Models, Animal; Encephalitis; Levetiracetam; Mice; Mono | 2022 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.
Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Encephalitis; Epilepsy | 2020 |
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cytokines; Dexamethasone; Dinoprostone; Disease Mode | 2018 |
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Calcium-Binding Proteins; Cyclooxygen | 2018 |
Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Cortex; Electroencephalography; Encepha | 2015 |
Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Hippocamp | 2015 |
Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cytokines; Deep Brain Stimulation; Disease Mode | 2015 |
The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy.
Topics: Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Encephalitis; Hippocampus; Interleu | 2016 |
The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Dinoprostone; Electroencephalography; Encephalitis; HSP72 Heat-Sh | 2016 |
Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis.
Topics: Aging; Animals; Astrocytes; Blood-Brain Barrier; Encephalitis; Fluorescein-5-isothiocyanate; Genes, | 2009 |
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.
Topics: Alprostadil; Animals; Blood-Testis Barrier; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Ele | 2011 |
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model.
Topics: Animals; Astrocytes; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fingol | 2012 |
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Disease Models, Animal; Encephalitis; Epilepsy, Tempo | 2008 |