pilocarpine has been researched along with Disease Models, Animal in 1113 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 8.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| "High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration." | 8.77 | Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Turski, L; Turski, WA, 1989) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 8.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 8.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 8.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " The aim of this study was to investigate the mechanism of action of ASP and GP through the experimental model of pilocarpine-induced seizures." | 8.31 | Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice. ( da SilvaTorres, IL; de Oliveira, JDM; Medeiros, HR; Pereira, P; Pflüger, P; Picada, JN; Uczay, M; Vendruscolo, MH; von Poser, G, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 8.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 8.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 8.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " The anxiety induced by pilocarpine was also significantly (P < 0." | 8.12 | Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. ( Bum, EN; Kouemou Emegam, N; Neteydji, S; Pale, S; Taiwe, GS, 2022) |
| "LiCl/pilocarpine status epilepticus (SE) induced in immature rats leads, after a latent period, to hippocampal hyperexcitability." | 8.12 | Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus. ( Fábera, P; Kubová, H; Mareš, P; Tsenov, G; Uttl, L, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 8.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 8.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 8.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 8.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures." | 8.02 | Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network. ( Dabirmanesh, B; Fathollahi, Y; Khajeh, K; Khorsand, B; Mirnajafi-Zadeh, J; Rizvanov, AA; Sadeghi, L; Salafutdinov, II; Sayyah, M; Shojaei, A; Zahiri, J, 2021) |
| " In the present study, the effects of CCR2 antagonist was investigated using the pilocarpine rat model of epilepsy." | 7.96 | Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy. ( Arisi, GM; Campbell, JJ; Foresti, ML; Mello, LE, 2020) |
| " Therefore, we investigated the expression pattern of GRIM-19 in the CA1 area of the hippocampus in 8-week-old male C57BL/6 mice following pilocarpine-induced status epilepticus (SE)." | 7.96 | Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus. ( Hwang, SN; Kim, JC; Kim, SY, 2020) |
| " Therefore, in the present study, we investigated the expression of parvalbumin (PV), one of the calcium-binding proteins, and morphological changes in the rat main olfactory bulb (MOB) following pilocarpine- induced status epilepticus (SE)." | 7.96 | Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. ( Kim, DS; Park, DK; Yoo, DY; Yu, YH, 2020) |
| " In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE." | 7.96 | Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice. ( Chen, C; Cheng, X; Lian, Y; Xie, N; Xu, H; Zhang, H; Zheng, Y, 2020) |
| "The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus." | 7.96 | The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model. ( Georgieva, K; Ivanova, N; Nenchovska, Z; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J, 2020) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 7.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " We aim in this study to investigate the neuroprotective effects of GL in a rat model after lithium-pilocarpine-induced status epilepticus (SE)." | 7.91 | Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus. ( Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B, 2019) |
| "We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine." | 7.91 | Coronary vasodilation impairment in pilocarpine model of epilepsy. ( Colugnati, DB; da Silva, M; de Castro, CH; Dos Santos, FCA; Ghazale, PP; Gomes, KP; Mendes, EP; Pansani, AP; Scorza, FA; Vitorino, PR, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 7.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation." | 7.91 | The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level. ( Atilla, P; Aydemir, O; Barun, S; Bulduk, EB; Kiziltas, M; Kurt, G; Muftuoglu, S; Oktem, M; Turhan, T, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 7.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| " We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpine-induced epilepsy in rats." | 7.91 | ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY. ( Cui, G; Ji, H; Kong, L; Liu, Y; Tang, H; Xiao, Q, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 7.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 7.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 7.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 7.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 7.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| "Currently, lacosamide (LCM) is not approved for use in status epilepticus (SE) but several shreds of evidence are available to support its use." | 7.88 | Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2. ( Nirwan, N; Siraj, F; Vohora, D, 2018) |
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 7.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| " Thus, we evaluated SV2A protein expression throughout the hippocampi of lithium-pilocarpine rats after status epilepticus (SE) and during early and late epilepsy." | 7.88 | Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model. ( Contreras-García, IJ; Gómez-González, B; Mendoza Torreblanca, JG; Pichardo-Macías, LA; Ramírez-Hernández, R; Rocha, L; Sánchez-Huerta, K; Santana-Gómez, CE, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 7.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 7.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| "We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy." | 7.85 | Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy. ( Karyakin, VB; Magazanik, LG; Vasil'ev, DS; Zaitsev, AV; Zhuravin, IA, 2017) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 7.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| " We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE." | 7.85 | Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus. ( Daninos, M; Tamir, I; Yaari, Y, 2017) |
| " When the brain slices were prepared from mice which underwent a pilocarpine-induced status epilepticus or when brain slices were incubated in pilocarpine-containing external medium, the sensitivity of P2X7 and P2Y1 receptors was invariably increased." | 7.85 | Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus. ( Araújo, MGL; Fernandes, MJS; Franke, H; Gao, P; Illes, P; Khan, MT; Krügel, U; Liu, J; Rong, W; Rozmer, K; Tang, Y, 2017) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 7.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE)." | 7.85 | TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. ( Abramowitz, J; Birnbaumer, L; Cozart, MA; Mock, MM; Phelan, KD; Shwe, UT; Wu, H; Zheng, F, 2017) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 7.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| " We hypothesized that pilocarpine-induced status epilepticus would disrupt oscillations and behavioral performance and that electrical neuromodulation to entrain theta would improve cognition specifically in injured rats." | 7.85 | Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus. ( Echeverri, A; Gurkoff, GG; Izadi, A; Lee, DJ; Melnik, M; Seidl, S; Shahlaie, K, 2017) |
| "This study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine-induced status epilepticus (SE), specifically those of brain-infiltrating leukocytes." | 7.85 | The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. ( Benson, MJ; Borges, K; Manzanero, S, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 7.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 7.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| "5h with pilocarpine to study anxiety-related behaviors, changes in the electroencephalogram of the cerebral cortex and hippocampus, and expression of hippocampal proteins." | 7.83 | Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice. ( Iida, Y; Itakura, M; Miyaoka, H; Ohkido, T; Otsuka, S; Saito, M; Takahashi, M; Watanabe, S; Yamamori, S, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " During pilocarpine induced status epilepticus, a transient down-regulation of neuronal CCR6 in the stratum oriens of CA1 was demonstrated at 2h during status epilepticus." | 7.83 | Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2016) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 7.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 7.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| " In the present study, we measured dendritic spine volume in mice injected with miR-134-targeting antagomirs and tested effects of the antagomirs on status epilepticus triggered by the cholinergic agonist pilocarpine." | 7.81 | Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. ( Conroy, RM; deFelipe, J; Engel, T; Fernaud-Espinosa, I; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Merino-Serrais, P; Reschke, CR; Reynolds, J; Rodriguez-Alvarez, N, 2015) |
| "A common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine, yet the mechanisms underlying the induction of pilocarpine-induced seizures (PISs) remain unclear." | 7.81 | Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. ( DeCan, E; Deisseroth, K; Lawrence, JJ; Marceau, E; Stoll, K; Yi, F, 2015) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 7.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 7.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| " To further address this issue, we investigated the progressive changes of Cx 43 and Cx 40 in the mouse hippocampus at 4 h, 1 day, 1 week and 2 months during and after pilocarpine-induced status epilepticus (PISE)." | 7.81 | Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Lu, QY; Song, TB; Tang, FR; Tang, YC; Wu, XL; Xiao, XL, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 7.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 7.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 7.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 7.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 7.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "In a previous study, we reported a persistent reduction of F-actin puncta but a compensating increase in puncta size in the mouse hippocampus at 2 months after pilocarpine-induced status epilepticus (Epilepsy Res." | 7.81 | The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus. ( Dai, G; Hou, Y; Li, S; Li, Y; Liu, H; Liu, J; Song, Y; Tan, B; Xiong, T; Zhang, Y, 2015) |
| "Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively." | 7.81 | Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. ( Chen, XM; Huang, LF; Liang, JJ; Lu, ZN; Pan, SQ; Xiao, ZM, 2015) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 7.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| "Triheptanoin, the triglyceride of heptanoate, is anticonvulsant in various epilepsy models." | 7.80 | Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. ( Borges, K; Hadera, MG; McDonald, TS; Smeland, OB; Sonnewald, U; Tan, KN, 2014) |
| "We investigated localization of Phospholipase C beta (PLCβ1 and PLCβ4) in laminaes of dorsal hippocampus and different subtypes of hippocampal interneurons in normal Kunming mouse, and their progressive changes during pilocarpine induced status epilepticus (SE) by quantitative immunohistochemistry and real time PCR." | 7.80 | Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xu, JH; Yang, PB; Zhang, JS, 2014) |
| " Thus, the aim of the present study was to evaluate the effect of sleep deprivation in the expression of microRNA (miRNA) in the frontal cortex and heart tissues of adult male rats after 50days of saline (SAL) or pilocarpine-induced status epilepticus (PILO)." | 7.80 | The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus. ( Andersen, ML; Cavalheiro, EA; Guindalini, C; Matos, G; Mazzotti, DR; Scorza, FA; Tufik, S, 2014) |
| " After pilocarpine-induced status epilepticus (SE), increases in neurotrophins regulate a wide variety of cell-signaling pathways, including prosurvival and cell-death machinery in a receptor-specific manner." | 7.80 | Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. ( Brooks-Kayal, AR; Carlsen, J; Cruz Del Angel, Y; Gonzalez, MI; Grabenstatter, HL; Hund, D; Longo, FM; Raol, YH; Russek, SJ; White, AM; Yang, T, 2014) |
| " Activity of Na(+),K(+)-ATPase decreased in the hippocampus of C57BL/6 mice 60 days after pilocarpine-induced status epilepticus (SE)." | 7.80 | Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit. ( de Oliveira, CV; Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, MS; Pereira, LM; Ribeiro, LR; Royes, LF, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 7.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 7.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 7.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of absence epilepsy." | 7.79 | A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. ( Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 7.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 7.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 7.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| " In the present study, we demonstrate the presence of CD11c-positive DCs in the hippocampus, thalamus and temporal cortex following Li-pilocarpine induced status epilepticus (SE) in rats." | 7.79 | Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats. ( Jiang, W; Li, XW; Ma, L; Wang, JC; Wang, YG; Yang, F, 2013) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 7.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| "Subconvulsant doses of pilocarpine promote long-lasting alterations on neural circuitry, reflected by an increased theta activity in the hippocampus and an anxiety-like profile of rats evaluated 1 month after the treatment which is independent of seizure occurrence and is not related to changes in glutamate uptake or hippocampal damage." | 7.79 | Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? ( Carobrez, AP; De Lima, TC; Duarte, FS; Duzzioni, M; Ern, AL; Gavioli, EC; Hoeller, AA; Lemos, T; Piermartiri, TC; Silva, NM; Tasca, CI, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 7.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| "We investigated the cellular localization and progressive changes of corticotropin releasing factor (CRF) in the mouse hippocampus, during and after pilocarpine induced status epilepticus (PISE) and subsequent epileptogenesis." | 7.78 | Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus. ( Ling, EA; Ma, DL; Tang, FR; Wu, J, 2012) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| " The present study aimed to test the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to detect MFS in the chronic phase of the well-established pilocarpine (Pilo) rat model of temporal lobe epilepsy (TLE)." | 7.78 | Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. ( Covolan, L; Longo, BM; Malheiros, JM; Mello, LE; Paiva, FF; Polli, RS; Silva, AC; Tannús, A, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 7.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 7.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "We investigated the protein expression of different protein kinase C (PKC) isoforms (PKC-alpha, PKC-beta1, PKC-beta2, PKC-gamma, PKC-delta, PKC-epsilon, PKC-eta and PKC-zeta) in the hippocampus of normal control mice and progressive changes in PKC isoforms expression during and after pilocarpine induced status epilepticus (PISE)." | 7.77 | Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice. ( Liu, JX; Liu, Y; Tang, FR, 2011) |
| "The present paper is the first work to determine the effect of lipopolysaccharide (LPS) in the pilocarpine model of epilepsy on the morphology of rat hippocampal astrocytes in vivo." | 7.77 | Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy. ( Cybulska, R; Dmowska, M; Jaworska-Adamu, J; Krawczyk, A; Pawlikowska-Pawlęga, B, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 7.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 7.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 7.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| "To examine the expression of IL-1beta, IL-1ra and IL-1R mRNA in the dentate gyrus of adult rats after lithium-pilocarpine (Li-PILO)-induced seizures." | 7.76 | [Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures]. ( Jiang, W; Li, XW; Wang, Y; Wei, D; Zhang, SJ, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 7.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 7.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 7.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| " We found that rats previously subjected to lithium-pilocarpine (LiPC)-induced neonatal status epilepticus (NeoSE) exhibited enhanced behavioral sensitization to methamphetamine (MA) in adolescence." | 7.75 | Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. ( Chen, GS; Huang, LT; Huang, YN; Lin, TC; Wang, JY, 2009) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 7.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| "The lithium-pilocarpine model of epilepsy in rat has been used extensively to investigate basic mechanisms of epilepsy and mimics human temporal lobe epilepsy." | 7.75 | Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy. ( Dupont, P; Goffin, K; Van Laere, K; Van Paesschen, W, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 7.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 7.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 7.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 7.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| "Recent evidence suggests that amiloride, a potent and nonselective blocker of acid-sensing ion channels, suppresses generalized seizures induced by maximal electroshock and pentylenetrazole." | 7.74 | Amiloride delays the onset of pilocarpine-induced seizures in rats. ( N'Gouemo, P, 2008) |
| " Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis." | 7.74 | Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| "Pilocarpine-induced status epilepticus (SE) mimics many features of temporal lobe epilepsy and is a useful model to study neural changes that result from prolonged seizure activity." | 7.74 | Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 7.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 7.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 7.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 7.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| ") injection of L-NAME (a nitric oxide synthase inhibitor) or CaEDTA (an extracellular zinc chelator) or the combination of the two could affect the initial phase of pilocarpine induced (2 h) seizures." | 7.74 | The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures. ( Danscher, G; Jensen, MS; Noyan, B, 2007) |
| " Neurochemical studies have proposed a role for catalase in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 7.74 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats. ( Barbosa, CO; Barros, DO; Freitas, RL; Freitas, RM; Maia, FD; Oliveira, AA; Silva, RF; Takahashi, RN; Xavier, SM, 2007) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 7.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 7.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "The aim of this pilot study was to investigate the antiepileptic effects of a novel noninvasive stimulation technique, transcutaneous electrical stimulation (TcES) via scalp concentric ring electrodes, on pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats. ( Besio, WG; Cole, AJ; Koka, K, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 7.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| " To study developmental changes of this role LiCl/pilocarpine status epilepticus (SE) was induced in P12, P25 and/or adult rats." | 7.74 | Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies. ( Kubová, H; Mares, P; Rocha, L; Suchomelová, L, 2007) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 7.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 7.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| " We studied the nestin distribution in the hippocampal formation of rats submitted to pilocarpine model of epilepsy." | 7.73 | Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Naffah-Mazzacoratti, MG; Scorza, CA; Scorza, FA, 2005) |
| "Multiple episodes of pilocarpine-induced status epilepticus (SE) in developing rats (P7-P9) lead to progressive epileptiform activity and severe cognitive impairment in adulthood." | 7.73 | Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; Cipelletti, B; Frassoni, C; Regondi, MC; Silva, AV; Spreafico, R, 2005) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including extensive limbic neuropathology." | 7.73 | Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2005) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 7.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| "To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that received pilocarpine and lovastatin (n=5)." | 7.73 | Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Rangel, P; Scorza, CA; Scorza, FA, 2005) |
| "The administration of lithium followed by pilocarpine induces status epilepticus (SE) that produces neurodegeneration and the subsequent development of spontaneous recurrent seizures." | 7.73 | Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. ( Dykstra, CM; Gurd, JW; Huo, JZ, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 7.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " Here, we investigated the effects of antazoline on NMDA toxicity and current in rat hippocampal neuronal cultures, and on an in vivo model of status epilepticus." | 7.72 | Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus. ( Bockaert, J; Lafon-Cazal, M; Lerner-Natoli, M; Milhaud, D; Rondouin, G, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 7.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| "In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine." | 7.72 | Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. ( Avedissian, M; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Longo, BM; Mello, LE; Pereira, CM, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 7.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| " Here, we examine two neuroprotective agents, the noncompetitive NMDA antagonist ketamine and the dopaminergic antagonist acepromazine, for their efficacy in attenuating cognitive impairments in the lithium-pilocarpine (LI-PILO) model of rat limbic epilepsy." | 7.72 | Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model. ( McKay, BE; Persinger, MA, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 7.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "The administration of pilocarpine (PILO) is widely recognized as resulting in an experimental model of temporal lobe epilepsy; it is characterized by induction of status epilepticus (SE) and spontaneous recurrent seizures after a latent period." | 7.72 | Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain). ( Furtado, Mde A; Garcia-Cairasco, N; Oliveira, JA; Rossetti, F, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 7.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "This study characterized the electrophysiological and neuropathological changes in rat brains caused by pilocarpine (PILO)-induced status epilepticus (SE) of different duration." | 7.71 | Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. ( Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J, 2002) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 7.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 7.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 7.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 7.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 7.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both." | 7.70 | Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study. ( Calderazzo, L; Cavalheiro, EA; Sanabria, ER; Scorza, FA, 1998) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 7.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 7.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 7.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 7.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 7.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "The chronically pilocarpine-treated rat has been proposed as an animal model for the disease cystic fibrosis, a generalized exocrinopathy." | 7.67 | The chronically pilocarpine-treated rat in the study of cystic fibrosis: investigations on submandibular gland and pancreas. ( Bardon, A; Ceder, O; Kuijpers, GA; Müller, RM; Roomans, GM, 1985) |
| "The antiglaucomatous effects of Glauplex 2 and pilocarpine nitrate on alpha-chymotrypsine-induced experimental glaucoma were studied in 8 rabbits." | 7.66 | [Comparative study of the antiglaucomatous activity of Glauplex 2 and pilocarpine nitrate on alpha-chymotrypsin-induced experimental glaucoma]. ( Andermann, G; Cannet, C; de Burlet, G, 1982) |
| "Status epilepticus is a neurological disorder that can result in various neuropathological conditions and presentations." | 7.01 | The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023). ( Che Has, AT, 2023) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 6.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 5.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 5.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 5.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 5.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "Demyelination is observed in animal models of intractable epilepsy (IE)." | 5.62 | Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study. ( Chen, Z; Gu, J; Ma, K; Niu, J; Tao, S; Wang, P; Wang, S; Wei, S; Yang, L; Ye, M; Zhang, G; Zhang, L, 2021) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 5.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "Gastrodin has shown the potential as an anticonvulsant." | 5.62 | Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model. ( Han, J; Li, Y; Wang, Y; Yang, Y, 2021) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 5.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 5.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "Pilocarpine-treated neonatal rats showed long-term abnormal neurobehavioral parameters." | 5.51 | Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. ( Chen, SH; Jin, MF; Li, LL; Ni, H, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 5.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 5.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3." | 5.48 | Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? ( Abbasova, K; Kubová, H; Mareš, P, 2018) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 5.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 5.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 5.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| " It is concluded that chronic administration β-estradiol has anticonvulsant and neuroprotective properties which are plausibly linked to astrocytic activity." | 5.46 | Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkar Boluki, T; Sarfi, M, 2017) |
| "Epilepsy affects 60 million people worldwide." | 5.46 | Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice. ( Benninger, F; Griffioen, K; Gross, A; Illouz, T; Madar, R; Offen, D; Okun, E; Steiner, I, 2017) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 5.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "However, its role in seizures and postictal outcomes is still not fully understood." | 5.42 | PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. ( Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 5.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
| "Status epilepticus affected male and female rats differentially." | 5.40 | Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup. ( Beltrán-Parrazal, L; López-Meraz, ML; Manzo, J; Medel-Matus, JS; Morgado-Valle, C; Pérez-Estudillo, C, 2014) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 5.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "Intraocular pressure was controlled by intracameral cannulation of mouse eyes while imaging using spectral-domain optical coherence tomography (SD-OCT)." | 5.40 | Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT. ( Chiu, SJ; Farsiu, S; Gonzalez, P; Li, G; Lütjen-Drecoll, E; Overby, DR; Stamer, WD, 2014) |
| "Proglumide (Pgm) is a known cholecystokinin (CCK) antagonist and any changes in the level of CCK and in the number of CCK receptors has been linked with SE." | 5.40 | Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus. ( Ahmad, M; Wadaan, MA, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 5.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 5.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Status epilepticus was induced in postnatal day 20 Sprague-Dawley rat pups with the chemoconvulsant lithium-pilocarpine and brain tissue was examined with Fluoro-Jade B." | 5.37 | Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus. ( Dudek, FE; Ekstrand, JJ; Pouliot, W; Scheerlinck, P, 2011) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 5.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "In the remaining animals that exhibited seizures, KB-R7943 pretreatment delayed the onset of seizures and status epilepticus, and reduced seizure severity." | 5.36 | Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. ( Martinez, Y; N'Gouemo, P, 2010) |
| "Edaravone (MCI-186) is a newly developed antioxidative radical scavenger for the treatment of acute cerebral infarction, exerting neuroprotective effects against ischemic insult." | 5.35 | Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. ( Abe, T; Anan, M; Fujiki, M; Kamida, T; Kobayashi, H; Ooba, H, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 5.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 5.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 5.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Convulsive status epilepticus is associated with subsequent hippocampal damage and development of mesial temporal sclerosis in a subset of individuals." | 5.34 | Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. ( Bamidele, A; Begum, S; Choy, M; de Castro, SC; Gadian, DG; Greene, ND; Leung, KY; Lythgoe, MF; Scott, RC; Wait, R, 2007) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 5.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 5.33 | Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model. ( Bracey, JM; Churn, SB; Holbert, WH; Lee, AT; Singleton, MW, 2005) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 5.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 5.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 5.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 5.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "Organized electrographic seizure activity developed just prior to the onset of behavioral forelimb clonus and appeared to originate from ventral forebrain in the vicinity of the ventral pallidum and/or nucleus accumbens." | 5.27 | The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. ( Clifford, DB; Collins, RC; Maniotis, A; Olney, JW; Zorumski, CF, 1987) |
| "Fundamental work on the mechanisms leading to focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial status epilepticus (SE) is induced by kainic acid or pilocarpine." | 5.12 | The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches. ( Avoli, M; Biagini, G; de Curtis, M; Gnatkovsky, V; Lévesque, M; Pitsch, J; Wang, S, 2021) |
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 4.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| "The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs)." | 4.85 | The pilocarpine model of epilepsy: what have we learned? ( Arida, RM; Calderazzo, L; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Scerni, DA; Scorza, FA, 2009) |
| "Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model." | 4.84 | The pilocarpine model of temporal lobe epilepsy. ( Avoli, M; Biagini, G; Curia, G; Jones, RS; Longo, D, 2008) |
| " Among post-status epilepticus models, induction of systemic kainic acid or pilocarpine-induced epilepsy is less labor-intensive than electrical-stimulation models and these models mirror the clinicopathologic features of MTLE more closely than do kindling, tetanus toxin, hyperthermia, post-traumatic, and perinatal hypoxia/ischemia models." | 4.84 | Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. ( Jordan, WH; Miller, MA; Reams, RY; Sharma, AK; Snyder, PW; Thacker, HL, 2007) |
| "High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration." | 4.77 | Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Turski, L; Turski, WA, 1989) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 4.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "Sprague Dawley rats underwent pilocarpine-induced status epilepticus and were maintained until the onset of spontaneous seizures." | 4.31 | Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy. ( Forcelli, PA; Ghosh, A; Hyder, SK, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 4.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " The aim of this study was to investigate the mechanism of action of ASP and GP through the experimental model of pilocarpine-induced seizures." | 4.31 | Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice. ( da SilvaTorres, IL; de Oliveira, JDM; Medeiros, HR; Pereira, P; Pflüger, P; Picada, JN; Uczay, M; Vendruscolo, MH; von Poser, G, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| " Here, tau expression and phosphorylation at three canonical loci known to be hyperphosphorylated in AD (S202/T205, T181, and T231) were studied in the rat pilocarpine status epilepticus (SE) model of temporal lobe epilepsy (TLE)." | 4.31 | Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy. ( Concepcion, FA; Ekstrom, NA; Estes, OO; Khan, MN; Poolos, NP, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 4.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " We recently found that in the pilocarpine-induced status epilepticus (PILO-SE) mouse model of TLE there was an increase in CA2 intrinsic excitability associated with a loss of CA2 synaptic inhibition." | 4.31 | Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. ( Barnett, A; Lisgaras, CP; Santoro, B; Scharfman, HE; Siegelbaum, SA; Whitebirch, AC, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 4.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 4.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " The anxiety induced by pilocarpine was also significantly (P < 0." | 4.12 | Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. ( Bum, EN; Kouemou Emegam, N; Neteydji, S; Pale, S; Taiwe, GS, 2022) |
| " Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a novel antiseizure strategy." | 4.12 | Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. ( Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S, 2022) |
| " We here examined for the first time the anticonvulsant effect of TCS2002, a specific and potent inhibitor of GSK-3β, in two models for limbic seizures: the pilocarpine rat model for focal seizures and the acute 6 Hz corneal mouse model for refractory seizures." | 4.12 | Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis. ( Allaoui, W; Aourz, N; De Bundel, D; Smolders, I; Van Eeckhaut, A; Van Leuven, F, 2022) |
| "LiCl/pilocarpine status epilepticus (SE) induced in immature rats leads, after a latent period, to hippocampal hyperexcitability." | 4.12 | Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus. ( Fábera, P; Kubová, H; Mareš, P; Tsenov, G; Uttl, L, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 4.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Levetiracetam (LEV) suppresses the upregulation of proinflammatory molecules that occurs during epileptogenesis after status epilepticus (SE)." | 4.12 | Regulation of Inflammation-Related Genes through ( Hashimoto, R; Ishihara, Y; Itoh, K; Komori, R; Kono, T; Kozawa, C; Kubo, S; Matsuo, T; Yokota-Nakatsuma, A, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 4.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| "Intrahippocampal pilocarpine microinjection (H-PILO) induces status epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents." | 4.12 | Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus. ( Amaral, MMC; Borbely, AU; Cummings, RD; de Araujo Costa, M; de Castro, OW; de Gusmão Taveiros Silva, NK; de Melo, IS; Dias-Baruffi, M; Donatti, ALF; Duzzioni, M; Fuzo, CA; Garcia-Cairasco, N; Gitaí, DLG; Mestriner, L; Pacheco, ALD; Santos, YMO; Silva, RS, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 4.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " First, at the beginning of epileptic chronic phase, 30 days post-pilocarpine-induced Status Epilepticus (SE)." | 4.02 | In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy. ( Calcagnotto, ME; Righes Marafiga, J; Vendramin Pasquetti, M, 2021) |
| " Pilocarpine epilepsy model mice with confirmed cluster pattern of spontaneous recurrent seizures by long-term video-electroencpehalography were sacrificed at the onset, peak, or end of a seizure cluster or in the seizure-free period." | 4.02 | Proteins related to ictogenesis and seizure clustering in chronic epilepsy. ( Chu, K; Han, D; Jeon, D; Jung, KH; Lee, SK; Lee, ST; Lee, WJ; Lim, JA; Moon, J; Park, DK; Park, KI; Yoo, JS, 2021) |
| "Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures." | 4.02 | Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network. ( Dabirmanesh, B; Fathollahi, Y; Khajeh, K; Khorsand, B; Mirnajafi-Zadeh, J; Rizvanov, AA; Sadeghi, L; Salafutdinov, II; Sayyah, M; Shojaei, A; Zahiri, J, 2021) |
| ") was administered 3 h after the pilocarpine-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.02 | Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy. ( Atanasova, D; Marinov, P; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y; Yoanidu, L, 2021) |
| " Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG)." | 4.02 | Limbic progesterone receptor activity enhances neuronal excitability and seizures. ( Batabyal, T; Joshi, S; Kapur, J; Labuz, A; Shiono, S; Sun, H; Williamson, J, 2021) |
| " In the present study, the effects of CCR2 antagonist was investigated using the pilocarpine rat model of epilepsy." | 3.96 | Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy. ( Arisi, GM; Campbell, JJ; Foresti, ML; Mello, LE, 2020) |
| " Therefore, we investigated the expression pattern of GRIM-19 in the CA1 area of the hippocampus in 8-week-old male C57BL/6 mice following pilocarpine-induced status epilepticus (SE)." | 3.96 | Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus. ( Hwang, SN; Kim, JC; Kim, SY, 2020) |
| " We used the lithium-pilocarpine-induced epilepsy model in adolescent Sprague-Dawley rats in order to evaluate hippocampal neurogenesis and epileptogenesis following the onset of status epilepticus (SE)." | 3.96 | The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. ( Chen, H; Chen, J; Cheng, L; Han, W; Jiang, L; Xie, L; Yuan, P, 2020) |
| "The present study tested whether ictal onset sites are regions of more severe interneuron loss in epileptic pilocarpine-treated rats, a model of human temporal lobe epilepsy." | 3.96 | Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats. ( Buckmaster, PS; Nagendran, M; Wyeth, M, 2020) |
| " Therefore, in the present study, we investigated the expression of parvalbumin (PV), one of the calcium-binding proteins, and morphological changes in the rat main olfactory bulb (MOB) following pilocarpine- induced status epilepticus (SE)." | 3.96 | Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. ( Kim, DS; Park, DK; Yoo, DY; Yu, YH, 2020) |
| " In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE." | 3.96 | Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice. ( Chen, C; Cheng, X; Lian, Y; Xie, N; Xu, H; Zhang, H; Zheng, Y, 2020) |
| "The lithium-pilocarpine-induced epilepsy model was established in rats." | 3.96 | Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons. ( Huang, HY; Li, F; Li, L; Lu, J; Qin, Y; Wang, Q; Xia, SS; Yang, P; Zhou, B; Zhu, Y, 2020) |
| "Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents." | 3.96 | Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity. ( Agam, G; Batra, AS; Belmaker, RH; Blackburn, V; Churchill, GC; Sade, Y; Saiardi, A; Serres, F; Sharp, T; Singh, N; Toker, L; Vasudevan, SR, 2020) |
| "The lithium-pilocarpine model in rats is commonly used to study the characteristic events of acute status epilepticus (SE), epileptogenesis and temporal lobe epilepsy (TLE)." | 3.96 | Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model. ( Alaqil, FA; Alasmari, AF; Alasmari, F; Alotaibi, FM; Alqahtani, F; Alqarni, SA; Anjum, SMM; Imran, I; Javaid, S; Rasool, MF; Samad, N; Shakeel, W, 2020) |
| "The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus." | 3.96 | The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model. ( Georgieva, K; Ivanova, N; Nenchovska, Z; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| "Based on combined behavioral, biochemical, and physiological analyses, we assessed the impact on animal well-being and condition in different phases of the pilocarpine post-status epilepticus (SE) model in rats." | 3.91 | Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model. ( Di Liberto, V; Hellweg, R; Koska, I; Möller, C; Palme, R; Potschka, H; Seiffert, I; van Dijk, RM, 2019) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 3.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Histological analysis and electrocorticograms (ECoG) were performed in animals fed with and without hypercholesterolemic diet before and during the status epilepticus induced by pilocarpine." | 3.91 | Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats? ( Costa, EVL; da Silva, ELA; Nogueira, RA; Pessoa, DT, 2019) |
| " Using serial hippocampal microdialysis collections starting two weeks after the pilocarpine-induced status epilepticus, we evaluated how this chronic epilepsy model affects molecule levels and their interactions." | 3.91 | Chemical biomarkers of epileptogenesis and ictogenesis in experimental epilepsy. ( Gliske, SV; Kennedy, RT; Luna-Munguia, H; Stacey, WC; Zestos, AG, 2019) |
| " We aim in this study to investigate the neuroprotective effects of GL in a rat model after lithium-pilocarpine-induced status epilepticus (SE)." | 3.91 | Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus. ( Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B, 2019) |
| "We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine." | 3.91 | Coronary vasodilation impairment in pilocarpine model of epilepsy. ( Colugnati, DB; da Silva, M; de Castro, CH; Dos Santos, FCA; Ghazale, PP; Gomes, KP; Mendes, EP; Pansani, AP; Scorza, FA; Vitorino, PR, 2019) |
| " In this study we used the pilocarpine-induced status epilepticus model of TLE (i." | 3.91 | Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 3.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation." | 3.91 | The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level. ( Atilla, P; Aydemir, O; Barun, S; Bulduk, EB; Kiziltas, M; Kurt, G; Muftuoglu, S; Oktem, M; Turhan, T, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 3.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| "A rat model of epilepsy was established using lithium chloride." | 3.91 | Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. ( Dai, D; Fu, WL; Li, Y; Liu, J; Xu, XW; Yang, JZ; Zhu, HX, 2019) |
| " We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpine-induced epilepsy in rats." | 3.91 | ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY. ( Cui, G; Ji, H; Kong, L; Liu, Y; Tang, H; Xiao, Q, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "The present study was designed to understand the molecular changes and cardiac parameters during different phases of epileptogenesis in lithium-pilocarpine (Li-pilo) rat model of epilepsy." | 3.91 | Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management. ( Mazumder, AG; Patial, V; Rana, AK; Sharma, S; Singh, D, 2019) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 3.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| " Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies." | 3.88 | Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. ( Canzian, JM; Duarte, MMMF; Duarte, T; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS, 2018) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 3.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 3.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| " Considering the importance in developing therapeutic strategies to prevent or modify epileptogenesis, we aimed the present study to test the hypothesis that atorvastatin modifies seizure susceptibility of mice after status epilepticus (SE)." | 3.88 | Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. ( Fighera, MR; Furian, AF; Oliveira, CV; Oliveira, MS; Royes, LFF; Zorzi, VN, 2018) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 3.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| " In this study, the mice were injected with methylazoxymethanol acetate (MAM) both before and after pilocarpine-induced status epilepticus (SE) to achieve an overall ablation of newborn cells contributing to the pathological recruitment." | 3.88 | Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice. ( Feng, GF; Hu, M; Li, CJ; Liu, JX; Liu, Y; Xu, JH; Yuan, B; Zhu, K, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 3.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| "To explore the role of cGKII in epilepsy, we investigated the expression of cGKII in patients with temporal lobe epilepsy (TLE) and in a pilocarpine-induced rat model and then performed behavioral, histological, and electrophysiological analyses by applying either a cGKII agonist or inhibitor in the hippocampus of the animal model." | 3.88 | Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1. ( Gu, J; Lin, P; Lin, Z; Lu, S; Luo, J; Ma, Y; Tian, X; Wang, W; Wang, X; Xiao, F; Xiong, Y; Xu, D; Yang, Q; Yang, Y; Zhang, Y, 2018) |
| "A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model." | 3.88 | The effect of dichloroacetate in mouse models of epilepsy. ( Borges, K; Durie, D; McDonald, TS, 2018) |
| "Currently, lacosamide (LCM) is not approved for use in status epilepticus (SE) but several shreds of evidence are available to support its use." | 3.88 | Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2. ( Nirwan, N; Siraj, F; Vohora, D, 2018) |
| "We have used voltage clamp recordings in isolated dentate granule cells (DGCs) and cortical pyramidal neurons of control versus chronically epileptic rats (pilocarpine model of epilepsy) and in DGCs isolated from hippocampal specimens from temporal lobe epilepsy patients to examine S-Lic effects on sodium channel slow inactivation." | 3.88 | Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells. ( Beck, H; Hebeisen, S; Holtkamp, D; Opitz, T; Soares-da-Silva, P, 2018) |
| "Morris water maze test was used to evaluate learning and memory deficits in pilocarpine-induced chronic epilepsy rats 12 weeks after status epilepticus." | 3.88 | Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [ ( Cheng, DF; Ding, J; Shi, HC; Si, Z; Wang, X; Wu, XQ; Zhao, YN, 2018) |
| " In addition, pilocarpine-induced neuronal damage and spontaneously recurrent seizures were evaluated after equivalent chemoconvulsant-induced status epilepticus was achieved by coadministration of the M-current-specific channel inhibitor, XE991." | 3.88 | Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis. ( Greene, DL; Hoshi, N; Kosenko, A, 2018) |
| " The GA group was given GA (150 μg/kg, ip) and the control group was given a saline injection prior to pilocarpine-induced seizures." | 3.88 | The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures. ( Huang, CW; Lai, MC; Lin, KM; Wu, SN; Yeh, PS, 2018) |
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 3.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| " Thus, we evaluated SV2A protein expression throughout the hippocampi of lithium-pilocarpine rats after status epilepticus (SE) and during early and late epilepsy." | 3.88 | Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model. ( Contreras-García, IJ; Gómez-González, B; Mendoza Torreblanca, JG; Pichardo-Macías, LA; Ramírez-Hernández, R; Rocha, L; Sánchez-Huerta, K; Santana-Gómez, CE, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 3.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " The epilepsy model was induced by injection of pilocarpine in rats." | 3.88 | [Efficacy of brain-targeted rapamycin for treatment of epilepsy in rats]. ( Dong, J; Liu, L; Wang, Q; Zeng, L; Zhang, B; Zhang, Y; Zhu, F, 2018) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 3.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| "We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy." | 3.85 | Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy. ( Karyakin, VB; Magazanik, LG; Vasil'ev, DS; Zaitsev, AV; Zhuravin, IA, 2017) |
| " In this study, we ablated the hippocampal neurogenesis by methylazoxymethanol acetate (MAM) treatment both before and after pilocarpine induced status epilepticus (SE)." | 3.85 | Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice. ( Feng, GF; Hu, M; Liu, JX; Liu, Y; Yuan, B; Zhu, K, 2017) |
| "Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video-electroencephalography (EEG) monitoring." | 3.85 | Neurosteroid-sensitive δ-GABA ( Joshi, S; Kapur, J; Rajasekaran, K; Williamson, J, 2017) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 3.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| " We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE." | 3.85 | Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus. ( Daninos, M; Tamir, I; Yaari, Y, 2017) |
| " In epileptic rats analyzed up to approximately two weeks after pilocarpine-induced status epilepticus (SE), these patterns are associated with specific high-frequency oscillation (HFO) content: ripples (80-200Hz) or fast-ripples (250-500Hz) predominate in LVF or HYP seizures, respectively." | 3.85 | Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Stroh, T, 2017) |
| "We aimed to discuss the mechanism of occurrence and progression of epilepsy through analyzing the expression changes of UCA1 and NF-Kb in temporal hippocampus and UCA1 in peripheral blood in rats with epilepsy induced by lithium chloride-pilocarpine." | 3.85 | Dynamic regulation effect of long non-coding RNA-UCA1 on NF-kB in hippocampus of epilepsy rats. ( Wang, HK; Wang, J; Wang, K; Yan, H, 2017) |
| "Transplantation of progenitor cells from embryonic medial or caudal ganglionic eminence (MGE, CGE) were made in a well-characterized mouse model of status epilepticus-induced epilepsy (systemic pilocarpine)." | 3.85 | Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors. ( Baraban, SC; Casalia, ML; Howard, MA, 2017) |
| "The aim of the present study was to investigate the role of paroxetine intervention in epilepsy, and its association with the expression of serotonin transporter (SERT) and hippocampal apoptosis." | 3.85 | Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats. ( Huang, HP; Li, XF; Lin, MX; Lin, WH; Zhou, Y, 2017) |
| " The rats in the model group were injected intraperitoneally with lithium chloride-pilocarpine hydrochloride to establish the rat model of status epilepticus (SE)." | 3.85 | The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus. ( Chen, L; Chen, S; Gao, Q; Hu, K; Jiang, D; Luo, W; Ouyang, D; Xiao, B; Xiao, J; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2017) |
| " Epileptogenesis was initiated using the pilocarpine status epilepticus model in male and female mice." | 3.85 | Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. ( Danzer, SC; Hosford, BE; Liska, JP; Rowley, S, 2017) |
| " When the brain slices were prepared from mice which underwent a pilocarpine-induced status epilepticus or when brain slices were incubated in pilocarpine-containing external medium, the sensitivity of P2X7 and P2Y1 receptors was invariably increased." | 3.85 | Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus. ( Araújo, MGL; Fernandes, MJS; Franke, H; Gao, P; Illes, P; Khan, MT; Krügel, U; Liu, J; Rong, W; Rozmer, K; Tang, Y, 2017) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 3.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE)." | 3.85 | TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. ( Abramowitz, J; Birnbaumer, L; Cozart, MA; Mock, MM; Phelan, KD; Shwe, UT; Wu, H; Zheng, F, 2017) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 3.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| " We hypothesized that pilocarpine-induced status epilepticus would disrupt oscillations and behavioral performance and that electrical neuromodulation to entrain theta would improve cognition specifically in injured rats." | 3.85 | Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus. ( Echeverri, A; Gurkoff, GG; Izadi, A; Lee, DJ; Melnik, M; Seidl, S; Shahlaie, K, 2017) |
| " Inhibition of SALM3 by SALM3 shRNA inhibited status epilepticus in the acute stage of disease and decreased spontaneous recurrent seizures in the Lithium-pilocarpine model of chronic stages of epilepsy." | 3.85 | Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models. ( Chen, L; Jiang, G; Li, J; Wang, N; Wu, Y; Zhang, Y, 2017) |
| "This study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine-induced status epilepticus (SE), specifically those of brain-infiltrating leukocytes." | 3.85 | The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. ( Benson, MJ; Borges, K; Manzanero, S, 2017) |
| "Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats." | 3.85 | Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats? ( Kubová, H; Mareš, P; Tsenov, G, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 3.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In this study, we investigated how DGC birthdate influences participation in MFS and other aspects of axonal plasticity using the rat pilocarpine-induced status epilepticus (SE) model of mTLE." | 3.83 | Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy. ( Althaus, AL; Parent, JM; Zhang, H, 2016) |
| " Lithium-pilocarpine model of seizures in rodents reproduces many features of human convulsive status epilepticus (SE) and subsequent TLE." | 3.83 | Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study. ( Abbasova, KR; Gulyaev, MV; Suleymanova, EM, 2016) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 3.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| " To determine if mTOR activation is necessary for abnormal granule cell development, transgenic mice that harbored fluorescently-labeled adult-born granule cells were treated with rapamycin following pilocarpine-induced status epilepticus." | 3.83 | Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain. ( Danzer, SC; Garcia-Cairasco, N; Hester, MS; Hosford, BE; LaSarge, CL; Liska, JP; Rolle, IJ; Santos, VR; Singh, SP, 2016) |
| "5h with pilocarpine to study anxiety-related behaviors, changes in the electroencephalogram of the cerebral cortex and hippocampus, and expression of hippocampal proteins." | 3.83 | Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice. ( Iida, Y; Itakura, M; Miyaoka, H; Ohkido, T; Otsuka, S; Saito, M; Takahashi, M; Watanabe, S; Yamamori, S, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Here, we used a FACS-based approach to discriminate between microglia and myeloid infiltrates isolated from the hippocampus 24 h and 96 h after status epilepticus (SE) in pilocarpine-treated CD1 mice." | 3.83 | Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus. ( Biagini, G; Boddeke, HW; Bordini, D; Curia, G; Dominici, M; Eggen, BJ; Giordano, C; Spano, C; Vainchtein, ID; Vinet, J, 2016) |
| " Lithium chloride- and pilocarpine-induced status epilepticus (LiCl/Pilo-SE) in rodents represents a model of severe seizures that result in development of temporal lobe epilepsy (TLE)." | 3.83 | Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors. ( Druga, R; Ergang, P; Kubová, H; Mareš, P; Salaj, M; Szczurowska, E, 2016) |
| " In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE)." | 3.83 | Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia. ( Balista, PA; Bassi, M; Do Val-da Silva, RA; Galvis-Alonso, OY; Glass, ML; Leite, JP; Peixoto-Santos, JE; Romcy-Pereira, RN; Scandiuzzi, RC, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " During pilocarpine induced status epilepticus, a transient down-regulation of neuronal CCR6 in the stratum oriens of CA1 was demonstrated at 2h during status epilepticus." | 3.83 | Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2016) |
| ") gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE)." | 3.83 | Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. ( Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E, 2016) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 3.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 3.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| " Using combined methods of behavioral testing, immunofluorescence and electrophysiological recordings, we characterized the anticonvulsant effect of RIN in a pilocarpine-induced status epilepticus (SE) rat model of temporal lobe epilepsy (TLE) and investigated the underlying cellular mechanisms." | 3.83 | Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy. ( Ji, WG; Mi, Z; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2016) |
| " Here, we perform a miRNA microarray analysis of the hippocampus of Wistar rats 24 hours after intra-hippocampal pilocarpine-induced Status Epilepticus (H-PILO SE)." | 3.83 | Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. ( Araújo, MA; Arroxelas-Silva, CL; Castro, OW; Duzzioni, M; Garcia-Cairasco, N; Góes Gitaí, DL; Kandratavicius, L; Leite, JP; Marques, TE; Octacílio-Silva, S; Paçó-Larson, ML; Passos, GA; Peixoto-Santos, JE; Pereira, MG, 2016) |
| " Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats." | 3.83 | Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. ( Chak, K; Kay, MA; Kemp, KC; Kim, HK; Porter, BE; Roy-Chaudhuri, B, 2016) |
| " In the present study, we measured dendritic spine volume in mice injected with miR-134-targeting antagomirs and tested effects of the antagomirs on status epilepticus triggered by the cholinergic agonist pilocarpine." | 3.81 | Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. ( Conroy, RM; deFelipe, J; Engel, T; Fernaud-Espinosa, I; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Merino-Serrais, P; Reschke, CR; Reynolds, J; Rodriguez-Alvarez, N, 2015) |
| "2 promoter activation, were imaged in vivo in the pilocarpine model of status epilepticus (SE)." | 3.81 | Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. ( Becker, AJ; Kulbida, R; Mandelkow, EM; Schoch, S; van Loo, KM; Wang, Y, 2015) |
| "Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including pilocarpine-induced status epilepticus." | 3.81 | Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Thind, K; Yamawaki, R, 2015) |
| "Eyes treated with pilocarpine developed approximately 6D myopia (p < 0." | 3.81 | Effects of muscarinic receptor modulators on ocular biometry of guinea pigs. ( Fang, F; Huang, F; Li, C; Liu, Y; Qu, J; Xie, R; Zhou, X; Zhu, Y, 2015) |
| "A common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine, yet the mechanisms underlying the induction of pilocarpine-induced seizures (PISs) remain unclear." | 3.81 | Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. ( DeCan, E; Deisseroth, K; Lawrence, JJ; Marceau, E; Stoll, K; Yi, F, 2015) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 3.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 3.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| " In the present study we studied seizure susceptibility along the longitudinal axis of the hippocampus following pilocarpine-induced status epilepticus (SE)." | 3.81 | Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. ( Holmes, GL; Isaev, D; Isaeva, E; Romanov, A, 2015) |
| " Ripples (80-200 Hz) and fast ripples (250-500 Hz) have been linked to each pattern, with ripples predominating during LVF seizures and fast ripples predominating during HYP seizures in the rat pilocarpine model." | 3.81 | Distinct EEG seizure patterns reflect different seizure generation mechanisms. ( Avoli, M; Gotman, J; Lévesque, M; Salami, P, 2015) |
| " To further address this issue, we investigated the progressive changes of Cx 43 and Cx 40 in the mouse hippocampus at 4 h, 1 day, 1 week and 2 months during and after pilocarpine-induced status epilepticus (PISE)." | 3.81 | Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Lu, QY; Song, TB; Tang, FR; Tang, YC; Wu, XL; Xiao, XL, 2015) |
| "As a result of the growing availability of genetically engineered mouse lines, the pilocarpine post-status epilepticus (SE) model of temporal lobe epilepsy is increasingly used in mice." | 3.81 | Pilocarpine-induced convulsive activity is limited by multidrug transporters at the rodent blood-brain barrier. ( Bankstahl, JP; Bankstahl, M; Löscher, W; Römermann, K, 2015) |
| " Status epilepticus evoked by pilocarpine administeration was used to induce epilepsy in rats." | 3.81 | Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients. ( Alsharafi, W; Xiao, B, 2015) |
| " Therefore, we modified kainic acid (KA)- and pilocarpine-induced status epilepticus (SE) models of epilepsy so that seizures were rare for the first months after SE, and conducted video-EEG during this time." | 3.81 | Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy. ( D'Amour, J; Fenton, AA; Friedman, D; LaFrancois, JJ; MacLusky, NJ; Magagna-Poveda, A; Moretto, J; Pearce, P; Scharfman, HE, 2015) |
| " To evaluate the possible roles of inhibitory neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of epileptic pilocarpine-treated rats as they experienced spontaneous seizures." | 3.81 | Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy. ( Buckmaster, PS; Fujita, S; Thamattoor, AK; Toyoda, I, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 3.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 3.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| " In the present study, we investigated the roles of ER stress in vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced status epilepticus (SE)." | 3.81 | Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. ( Hyun, HW; Kim, JE; Kim, JY; Ko, AR, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "Pilocarpine-induced status epilepticus causes a rapid increase of multiple cytokines in limbic and neocortical regions." | 3.81 | Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures. ( Arisi, GM; Foresti, ML; Katki, K; Shapiro, LA, 2015) |
| " In this study, we used the pilocarpine model of MTLE to establish the effects of a third generation drug, lacosamide (LCM), on seizures, interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz)." | 3.81 | Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Ragsdale, D, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| "In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model." | 3.81 | Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats. ( Hyun, HW; Kim, JE; Kim, JY; Ko, AR, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 3.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| " To address the issue, newly generated cells in the sub-granular zone of the dentate gyrus were labeled by the proliferation marker bromodeoxyuridine (BrdU) or retroviral vector expressing green fluorescent protein 2 months after pilocarpine-induced status epilepticus." | 3.81 | Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xiao, XL; Zhang, JS; Zhang, YJ; Zhu, K, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 3.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 3.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "In a previous study, we reported a persistent reduction of F-actin puncta but a compensating increase in puncta size in the mouse hippocampus at 2 months after pilocarpine-induced status epilepticus (Epilepsy Res." | 3.81 | The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus. ( Dai, G; Hou, Y; Li, S; Li, Y; Liu, H; Liu, J; Song, Y; Tan, B; Xiong, T; Zhang, Y, 2015) |
| "Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively." | 3.81 | Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. ( Chen, XM; Huang, LF; Liang, JJ; Lu, ZN; Pan, SQ; Xiao, ZM, 2015) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 3.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| "Triheptanoin, the triglyceride of heptanoate, is anticonvulsant in various epilepsy models." | 3.80 | Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. ( Borges, K; Hadera, MG; McDonald, TS; Smeland, OB; Sonnewald, U; Tan, KN, 2014) |
| "Taken together, this highlights pilocarpine through the activation of muscarinic receptors appear to afford significant protection against retinal neurons damage and optic nerve degeneration at clinically relevant concentrations." | 3.80 | Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models. ( Chen, HZ; Cui, YY; Feng, XM; Li, H; Qiu, Y; Tan, PP; Yuan, HH; Zhou, W; Zhu, X, 2014) |
| "The periodontitis model showed significant reductions in the weight of the bilateral major salivary glands and pilocarpine-induced salivary secretion." | 3.80 | Changes of salivary functions in experimental periodontitis model rats. ( Hitomi, S; Inenaga, K; Masuda, W; Matsuo, K; Nakamura-Kiyama, M; Nakashima, K; Ono, K; Usui, M; Yokota, M, 2014) |
| "In the mouse pilocarpine-induced epilepsy model, we administered levetiracetam (LEV) and valproate (VPA) in sequence." | 3.80 | Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model. ( Ban, JJ; Choi, J; Chu, K; Jeon, D; Jung, KH; Khalid, A; Kim, JM; Lee, SK; Lee, ST; Moon, J; Park, KI; Shin, JW; Yang, H; Yi, GS, 2014) |
| "We investigated localization of Phospholipase C beta (PLCβ1 and PLCβ4) in laminaes of dorsal hippocampus and different subtypes of hippocampal interneurons in normal Kunming mouse, and their progressive changes during pilocarpine induced status epilepticus (SE) by quantitative immunohistochemistry and real time PCR." | 3.80 | Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xu, JH; Yang, PB; Zhang, JS, 2014) |
| " Thus, the aim of the present study was to evaluate the effect of sleep deprivation in the expression of microRNA (miRNA) in the frontal cortex and heart tissues of adult male rats after 50days of saline (SAL) or pilocarpine-induced status epilepticus (PILO)." | 3.80 | The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus. ( Andersen, ML; Cavalheiro, EA; Guindalini, C; Matos, G; Mazzotti, DR; Scorza, FA; Tufik, S, 2014) |
| "Lithium chloride-pilocarpine-induced rats with status epilepticus (SE) were established." | 3.80 | Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. ( Du, Y; Liu, W; Shi, R; Yang, W; Yu, W; Zhao, N; Zou, Y, 2014) |
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| "Thirty-five Sprague-Dawley rats were subjected to lithium-pilocarpine status epilepticus." | 3.80 | Attention and executive functions in a rat model of chronic epilepsy. ( Akimana, G; Barbelivien, A; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Herbeaux, K; Koning, E; Marques-Carneiro, JE; Nehlig, A, 2014) |
| " After pilocarpine-induced status epilepticus (SE), increases in neurotrophins regulate a wide variety of cell-signaling pathways, including prosurvival and cell-death machinery in a receptor-specific manner." | 3.80 | Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. ( Brooks-Kayal, AR; Carlsen, J; Cruz Del Angel, Y; Gonzalez, MI; Grabenstatter, HL; Hund, D; Longo, FM; Raol, YH; Russek, SJ; White, AM; Yang, T, 2014) |
| " A similar profusion of immature GABAergic cells was seen in rats with pilocarpine-induced chronic epilepsy." | 3.80 | Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation. ( DeFranco, DB; Di Maio, R; Kanuparthi, PS; Samarasinghe, RA; Timothy Greenamyre, J, 2014) |
| " Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the main features of mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) in humans, we examined the expression of CB1R in hippocampal astrocytes of epileptic rats." | 3.80 | Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi. ( Jiang, W; Kang, JJ; Li, J; Liu, YY; Ma, L; Meng, XD; Ou-Yang, TP; Wei, D; Wu, C; Yang, F; Zhu, GM, 2014) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| " Activity of Na(+),K(+)-ATPase decreased in the hippocampus of C57BL/6 mice 60 days after pilocarpine-induced status epilepticus (SE)." | 3.80 | Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit. ( de Oliveira, CV; Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, MS; Pereira, LM; Ribeiro, LR; Royes, LF, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 3.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| " To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expression of key components in the glutamate-glutamine cycle, known to be affected in MTS patients." | 3.80 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 3.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 3.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Behaviors of calcium/calmodulin-dependent protein kinase II alpha (α-CaMKII) heterozygous knock-out (KO) mice, which are a representative bipolar disorder/schizophrenia model displaying iDG, and pilocarpine-treated mice, which are a representative epilepsy model, were tested followed by quantitative polymerase chain reaction (qPCR)/immunohistochemistry for mRNA/protein expression associated with an iDG phenotype." | 3.79 | The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease. ( Chen, Q; Gross, AK; Hagihara, H; Heusner, CL; Kobayashi, K; Kogan, JH; Matsumoto, M; Miyakawa, T; Miyake, S; Shin, R; Tajinda, K; Tamura, K; Walton, NM, 2013) |
| "Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of absence epilepsy." | 3.79 | A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. ( Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L, 2013) |
| " We next used 2 models presenting with increased BBB permeability, hypoxia/reoxygenation and pilocarpine-induced status epilepticus, to assess the response of VWF(-/-) animals." | 3.79 | Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. ( Brill, A; Cabral, JE; Cifuni, SM; De Meyer, SF; Suidan, GL; Voorhees, JR; Wagner, DD, 2013) |
| " The present paper is the continuation of our previous study which has shown an increased occurrence of creatine inclusions in rat hippocampal formations from the acute phase of pilocarpine-induced status epilepticus (SE) and positive correlation between their quantity and the total time of seizure activity within the observation period." | 3.79 | Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy. ( Chwiej, J; Dumas, P; Janeczko, K; Kutorasinska, J; Sandt, C; Setkowicz, Z, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 3.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 3.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 3.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| " NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpine-induced status epilepticus (PISE)." | 3.79 | STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. ( Cai, X; Chen, S; Chen, Y; Chen, Z; Fang, Z; Wang, Q; Yang, L; Zhou, J; Zhou, L, 2013) |
| " Using an antibody selective to pTrkB in conjunction with confocal microscopy and cellular markers, we determined the cellular and subcellular locale of enhanced pTrkB induced by status epilepticus (SE) evoked by infusion of kainic acid into the amygdala of adult mice." | 3.79 | The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. ( Helgager, J; Liu, G; McNamara, JO, 2013) |
| " In the present study, we demonstrate the presence of CD11c-positive DCs in the hippocampus, thalamus and temporal cortex following Li-pilocarpine induced status epilepticus (SE) in rats." | 3.79 | Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats. ( Jiang, W; Li, XW; Ma, L; Wang, JC; Wang, YG; Yang, F, 2013) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 3.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| "Subconvulsant doses of pilocarpine promote long-lasting alterations on neural circuitry, reflected by an increased theta activity in the hippocampus and an anxiety-like profile of rats evaluated 1 month after the treatment which is independent of seizure occurrence and is not related to changes in glutamate uptake or hippocampal damage." | 3.79 | Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? ( Carobrez, AP; De Lima, TC; Duarte, FS; Duzzioni, M; Ern, AL; Gavioli, EC; Hoeller, AA; Lemos, T; Piermartiri, TC; Silva, NM; Tasca, CI, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice." | 3.79 | Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice. ( Cavalcante Melo, FH; de Carvalho Lima, CN; de França Fonteles, MM; Freire Vasconcelos, L; Leite Dias, M; Moura Rocha, NF; Rodrigues Carvalho, AM; Soares Lopes, K; Vasconcelos Rios, ER, 2013) |
| "Loss of neurons occurs with aging and following lithium/pilocarpine-induced epileptic seizures." | 3.79 | Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains. ( Karbowski, LM; Parker, GH; Persinger, MA, 2013) |
| " The purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE)." | 3.79 | Sexual response in female rats with status epilepticus. ( Alvarenga, TA; Amado, D; Andersen, ML; Cavalheiro, EA; Matos, G; Scorza, FA; Tufik, S, 2013) |
| " We found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely." | 3.79 | Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ( Dingledine, R; Dudek, FE; Ganesh, T; Jiang, J; Pouliot, WA; Quan, Y, 2013) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 3.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| " Finally, we investigated its effects on pilocarpine-induced seizures in rats." | 3.78 | Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. ( Chow, JC; Huang, CW; Tsai, JJ; Wu, SN, 2012) |
| "We investigated the cellular localization and progressive changes of corticotropin releasing factor (CRF) in the mouse hippocampus, during and after pilocarpine induced status epilepticus (PISE) and subsequent epileptogenesis." | 3.78 | Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus. ( Ling, EA; Ma, DL; Tang, FR; Wu, J, 2012) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| " The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB(1) -receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE)." | 3.78 | Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. ( Blair, RE; DeLorenzo, RJ; Nguyen, PT; Sayers, KW; Sim-Selley, LJ, 2012) |
| " Following pilocarpine-induced status epilepticus (SE), experimental animals not only developed spontaneous recurrent seizures, but also exhibited significantly elevated levels of aggressive behavior." | 3.78 | Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy. ( Huang, X; Huang, Y; McMahon, J, 2012) |
| " The present study aimed to test the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to detect MFS in the chronic phase of the well-established pilocarpine (Pilo) rat model of temporal lobe epilepsy (TLE)." | 3.78 | Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. ( Covolan, L; Longo, BM; Malheiros, JM; Mello, LE; Paiva, FF; Polli, RS; Silva, AC; Tannús, A, 2012) |
| "Experimental TLE was triggered by pilocarpine- or kainic acid-induced status epilepticus (SE)." | 3.78 | Changes in interictal spike features precede the onset of temporal lobe epilepsy. ( Bartolomei, F; Bernard, C; Chauvière, L; Doublet, T; Ghestem, A; Huys, R; Jirsa, V; Siyoucef, SS; Wendling, F, 2012) |
| " Results from 2413 mice were evaluated for effects of sex, age, body weight, and latency between administration of atropine methyl bromide and pilocarpine." | 3.78 | Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Haney, MM, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 3.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " Additionally, the anticonvulsant profile of CBDV (50-200 mg·kg(-1) ) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats." | 3.78 | Cannabidivarin is anticonvulsant in mouse and rat. ( Duncan, M; Futamura, T; Glyn, SE; Hill, AJ; Hill, TD; Jones, NA; Mercier, MS; Stephens, GJ; Stott, CG; Whalley, BJ; Williams, CM; Yamasaki, Y, 2012) |
| "The lithium-pilocarpine-induced status epilepticus model and the temporal lobe epilepsy model were established in Sprague-Dawley rats." | 3.78 | MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus. ( Feng, L; Hu, K; Li, Y; Long, HY; Long, LL; Ouyang, DS; Sun, DN; Xiao, B; Xie, YY; Zhang, C, 2012) |
| " In the study, one of the status epilepticus animal models of epilepsy was used, namely the model of temporal lobe epilepsy with pilocarpine-induced seizures." | 3.78 | Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study. ( Appel, K; Chwiej, J; Gzielo-Jurek, K; Janeczko, K; Kutorasinska, J; Setkowicz, Z; Simon, R; Uram, L, 2012) |
| " We assessed the susceptibility to epilepsy after subthreshold dose of pilocarpine, as well as glial fibrillary acidic protein (GFAP) expression using immunohistochemistry." | 3.78 | Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine. ( Feng, B; Pan, XH; Sun, HL; Wang, CY; Xu, Y; Yang, LX; Zhang, SH; Zhang, SP; Zhong, K; Zhu, W, 2012) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "We analyzed corticostriatal long-term potentiation (LTP) in brain slices of pilocarpine-treated rats after status epilepticus (SE)." | 3.77 | Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy. ( Avchalumov, Y; Kirschstein, T; Köhling, R, 2011) |
| "The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures." | 3.77 | Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. ( Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY, 2011) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 3.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "After pilocarpine-induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus." | 3.77 | Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy. ( Cameron, MC; Nadler, JV; Zhan, RZ, 2011) |
| " We induced cortical malformations by exposing rats prenatally to methylazoxymethanol acetate and triggered status epilepticus and recurrent seizures in adult methylazoxymethanol acetate rats with pilocarpine." | 3.77 | Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia. ( Balosso, S; Battaglia, G; Carriero, G; Colciaghi, F; Finardi, A; Frasca, A; Locatelli, D; Nobili, P; Vezzani, A, 2011) |
| "Pilocarpine was used to induce seizures in adult rats wild-type and perforin-deficient mice." | 3.77 | Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures. ( Cucullo, L; Fabene, PF; Ghosh, C; Janigro, D; Johnson, AJ; Johnson, HL; Marchi, N; Puvenna, V; Tierney, W, 2011) |
| "We investigated the protein expression of different protein kinase C (PKC) isoforms (PKC-alpha, PKC-beta1, PKC-beta2, PKC-gamma, PKC-delta, PKC-epsilon, PKC-eta and PKC-zeta) in the hippocampus of normal control mice and progressive changes in PKC isoforms expression during and after pilocarpine induced status epilepticus (PISE)." | 3.77 | Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice. ( Liu, JX; Liu, Y; Tang, FR, 2011) |
| "The present paper is the first work to determine the effect of lipopolysaccharide (LPS) in the pilocarpine model of epilepsy on the morphology of rat hippocampal astrocytes in vivo." | 3.77 | Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy. ( Cybulska, R; Dmowska, M; Jaworska-Adamu, J; Krawczyk, A; Pawlikowska-Pawlęga, B, 2011) |
| "Acute application of human ASCs-E before SE led to earlier attenuation of seizure spike activities after treatment with diazepam, reduction of BBB leakage, and inhibition of the development of epilepsy." | 3.77 | A cell-free extract from human adipose stem cells protects mice against epilepsy. ( Ban, JJ; Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, M; Kim, S; Lee, SK; Lee, ST; Roh, JK; Seo, JS; Won, CH, 2011) |
| "Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy." | 3.77 | Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. ( Bajorat, R; Kirschstein, T; Köhling, R; Sellmann, T; Wilde, M, 2011) |
| " This "period without stimulus" was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150." | 3.77 | Early physical exercise and seizure susceptibility later in life. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Scorza, FA; Silva Araújo, BH, 2011) |
| "Status epilepticus was induced by systemic pilocarpine treatment in green fluorescent protein (GFP)-expressing inhibitory nerurons (GIN) mice in which a subset of somatostatin interneurons expresses GFP." | 3.77 | Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Wen, X, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 3.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| " The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice." | 3.77 | Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. ( Afrikanova, T; Clinckers, R; Crawford, AD; de Witte, PA; Esguerra, CV; Loyens, E; Massie, A; Michotte, Y; Schallier, A; Serruys, AS; Smolders, I; Vermoesen, K, 2011) |
| "Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats." | 3.77 | Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. ( Cox, CB; Ermolinsky, BS; Farrell, B; Garrido-Sanabria, ER; Nair, S; Pacheco, LF; Ruiz, N, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " We examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between TLE and depression, which developed in Wistar rats following pilocarpine status epilepticus (SE)." | 3.76 | Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2010) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 3.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 3.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " To better define the role of increased homocysteine in epilepsy, we analyzed the effects of homocysteine pretreatment in the pilocarpine model of status epilepticus (SE), which is used to mimic temporal lobe epilepsy (TLE) in rodents." | 3.76 | Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment. ( Agnati, LF; Andreoli, N; Baldelli, E; Biagini, G; Fuxe, K; Leo, G, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| "To explore the mechanism underlying the development of learning deficits in patients with epilepsy, we generated a mouse model for temporal lobe epilepsy by intraperitoneally injecting mice with pilocarpine with lithium chloride, and investigated time-dependent changes in both contextual fear memory of those model mice and long-term potentiation (LTP) in hippocampal CA1 neurons 1 day, 2 weeks, and 6 weeks after the onset of status epilepticus (SE)." | 3.76 | Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model. ( Cai, GE; Ju, G; Li, ST; Lu, QC; Yang, Q; Zhang, Y, 2010) |
| "To examine the expression of IL-1beta, IL-1ra and IL-1R mRNA in the dentate gyrus of adult rats after lithium-pilocarpine (Li-PILO)-induced seizures." | 3.76 | [Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures]. ( Jiang, W; Li, XW; Wang, Y; Wei, D; Zhang, SJ, 2010) |
| " A pilocarpine-induced status epilepticus mouse model of TLE was used to study the effect of cannabinoid agonists on recurrent excitatory circuits of the dentate gyrus using electrophysiological recordings in hippocampal slices isolated from control mice and mice with TLE." | 3.76 | Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. ( Bhaskaran, MD; Smith, BN, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 3.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| " We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent with a depressive state: behavioral equivalents of anhedonia and despair, dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, and compromised raphe-hippocampal serotonergic transmission." | 3.76 | Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D, 2010) |
| " In the rat Li-pilocarpine status epilepticus model, CYM2503, injected intraperitoneally, increased the latency to first electrographic seizure and the latency to first stage 3 behavioral seizure, decreased the latency to the establishment of status epilepticus, and dramatically decreased the mortality." | 3.76 | GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. ( Baldwin, R; Bartfai, T; Chang, J; Liu, T; Lu, X; Roberts, E; Sanchez-Alavez, M; Wasterlain, CG; Wu, S; Xia, F, 2010) |
| "We analyzed with EEG-video monitoring the epileptic activity recorded during the latent and chronic periods in rats undergoing 30 or 120 min pilocarpine-induced convulsive status epilepticus (SE)." | 3.76 | Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system. ( Avoli, M; Biagini, G; Bortel, A; Gotman, J; Lévesque, M, 2010) |
| " We previously reported that endogenous VEGF protein is dramatically upregulated after pilocarpine-induced status epilepticus in the rat, and that intra-hippocampal infusions of recombinant human VEGF significantly protected against the loss of hippocampal CA1 neurons in this model (Nicoletti JN, Shah SK, McCloskey DP, et al." | 3.76 | Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats. ( Betancourth, D; Croll, SD; Elkady, A; Khalid, S; Lenzer, J; Nicoletti, JN; Quinteros, D; Rotella, F; Salerni, EA; Shah, SK, 2010) |
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 3.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| "Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)." | 3.75 | Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 3.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| "Extreme obesity slowly develops in female rats over the months following seizures induced by a single systemic injection of lithium and pilocarpine if the resulting limbic seizures are treated with the atypical neuroleptic acepromazine (but not with ketamine)." | 3.75 | Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity. ( Bubenik, GA; Parker, GH; Persinger, MA; St-Pierre, LS, 2009) |
| " We sought to determine which cells express P450cc and whether neurosteroids play a role in the regulation of epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.75 | Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period. ( Avoli, M; Baldelli, E; Bertazzoni, G; Biagini, G; Longo, D; Rogawski, MA; Zoli, M, 2009) |
| " We found that rats previously subjected to lithium-pilocarpine (LiPC)-induced neonatal status epilepticus (NeoSE) exhibited enhanced behavioral sensitization to methamphetamine (MA) in adolescence." | 3.75 | Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. ( Chen, GS; Huang, LT; Huang, YN; Lin, TC; Wang, JY, 2009) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 3.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| "The lithium-pilocarpine model of epilepsy in rat has been used extensively to investigate basic mechanisms of epilepsy and mimics human temporal lobe epilepsy." | 3.75 | Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy. ( Dupont, P; Goffin, K; Van Laere, K; Van Paesschen, W, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 3.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 3.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| " Moreover, pilocarpine induced a significant down-regulation of APLP1 mRNA expression at 6 h after epilepsy initiation (P< 0." | 3.75 | Down-regulation of APLP1 mRNA expression in hippocampus of pilocarpine-induced epileptic rats. ( Wang, C; You, ZL; Zhang, DD, 2009) |
| "In rodents, the cholinomimetic convulsant pilocarpine is widely used to induce status epilepticus (SE), followed by hippocampal damage and spontaneous recurrent seizures, resembling temporal lobe epilepsy." | 3.75 | Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice. ( Gröticke, I; Hoffmann, K; Löscher, W; Müller, CJ; Schughart, K, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 3.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Rapamycin was focally, continuously, and unilaterally infused into the dorsal hippocampus for prolonged periods beginning within hours after rats sustained pilocarpine-induced status epilepticus." | 3.75 | Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. ( Buckmaster, PS; Ingram, EA; Wen, X, 2009) |
| "In the present study, we explored the consequences of epilepsy on the neurobehavioral development of the offspring in a rat model of spontaneous epilepsy, the lithium-pilocarpine model of temporal lobe epilepsy not dependent on genetic factors and in animals not receiving any antiepileptic treatment." | 3.75 | Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model. ( Boehrer, A; de Vasconcelos, AP; Desor, D; Nehlig, A; Raffo, E, 2009) |
| "This study was designed to evaluate the effects of pilocarpine and explore the underlying ionic mechanism, using both aconitine-induced rat and ouabain-induced guinea pig arrhythmia models." | 3.75 | The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models. ( Chen, LP; Chen, W; Han, HM; Li, DL; Liu, Y; Pan, ZY; Qi, HP; Sun, HL; Wang, LY; Xie, J; Zhao, WM, 2009) |
| "Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence." | 3.75 | Alcohol consumption and sudden unexpected death in epilepsy: experimental approach. ( Arida, RM; Cavalheiro, EA; Cysneiros, RM; de Almeida, AC; Machado, HR; Scorza, FA; Scorzai, CA; Terra, VC, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 3.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| "Recent evidence suggests that amiloride, a potent and nonselective blocker of acid-sensing ion channels, suppresses generalized seizures induced by maximal electroshock and pentylenetrazole." | 3.74 | Amiloride delays the onset of pilocarpine-induced seizures in rats. ( N'Gouemo, P, 2008) |
| " Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis." | 3.74 | Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| "BmK IT2 showed anticonvulsant activity as it inhibited the widespread seizures induced by PTZ and pilocarpine-induced SE in rats." | 3.74 | Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy. ( Ji, YH; Jiang, LL; Shu, XQ; Weng, CC; Yang, J; Zhang, JW; Zhang, XY; Zhao, R, 2008) |
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus." | 3.74 | Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| "Pilocarpine-induced status epilepticus (SE) mimics many features of temporal lobe epilepsy and is a useful model to study neural changes that result from prolonged seizure activity." | 3.74 | Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2008) |
| " Proneurotrophins, which are potent apoptosis-inducing ligands for p75(NTR), were increased in the hippocampus, particularly in astrocytes, by pilocarpine-induced seizures; and infusion of anti-pro-NGF dramatically attenuated neuronal loss after seizures." | 3.74 | Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. ( Carter, BD; Cragnolini, A; Friedman, WJ; Hempstead, BL; Kenchappa, RS; Light, M; Trotter, C; Volosin, M, 2008) |
| " Animals (n = 14) were administered pilocarpine to induce status epilepticus." | 3.74 | Oral administration of fructose-1,6-diphosphate has anticonvulsant activity. ( Lian, XY; Stringer, JL; Xu, K, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 3.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 3.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| "Lithium-pilocarpine status epilepticus (SE) resulted in delayed changes of single cortical interhemisperic (transcallosal) responses in immature rats." | 3.74 | Depression and/or potentiation of cortical responses after status epilepticus in immature rats. ( Mares, P; Tsenov, G, 2007) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 3.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "Lithium-pilocarpine-induced status epilepticus (SE) generates neuronal lesions in the limbic forebrain, cerebral cortex and thalamus that lead to circuit reorganization and spontaneous recurrent seizures." | 3.74 | Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat. ( Boehm, N; Hanaya, R; Nehlig, A, 2007) |
| ") injection of L-NAME (a nitric oxide synthase inhibitor) or CaEDTA (an extracellular zinc chelator) or the combination of the two could affect the initial phase of pilocarpine induced (2 h) seizures." | 3.74 | The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures. ( Danscher, G; Jensen, MS; Noyan, B, 2007) |
| " Neurochemical studies have proposed a role for catalase in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 3.74 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats. ( Barbosa, CO; Barros, DO; Freitas, RL; Freitas, RM; Maia, FD; Oliveira, AA; Silva, RF; Takahashi, RN; Xavier, SM, 2007) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 3.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| " In this study, we analyzed the contribution of neuronal necrosis and caspase-3 activation to CA1 damage following lithium-pilocarpine SE in P14 rat pups." | 3.74 | Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. ( Allen, S; Archie, M; Auvin, S; Niquet, J; Sankar, R; Seo, DW; Wasterlain, CG, 2007) |
| "Sixty-one SD rats underwent intraperitoneal injection of lithium chloride and pilocarpine to establish models of status epilepticus characterized with temporal lobe epilepsy." | 3.74 | [Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy]. ( Chen, YC; Huang, YG; Lin, H; Wen, XN; Wu, LW, 2007) |
| " In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybutyrate lactone (GBL)-induced absence seizure model." | 3.74 | Anti-glutamatergic effect of riluzole: comparison with valproic acid. ( Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK, 2007) |
| " The recordings were performed in epileptic rats 24 h after an early behavioural spontaneous seizure between 5 and 21 days after pilocarpine-induced status epilepticus." | 3.74 | Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. ( Mello, LE; Queiroz, CM, 2007) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 3.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| " Electron microscopic immunolabeling was therefore used to determine if mossy cell axon terminals form synapses with hilar EGC dendrites, using animals that underwent pilocarpine-induced status epilepticus." | 3.74 | Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. ( McCloskey, DP; Pierce, JP; Punsoni, M; Scharfman, HE, 2007) |
| "A common experimental model of status epilepticus (SE) utilizes intraperitoneal administration of the cholinergic agonist pilocarpine preceded by methyl-scopolamine treatment." | 3.74 | In vivo and in vitro effects of pilocarpine: relevance to ictogenesis. ( Batra, A; De Curtis, M; Hernandez, N; Janigro, D; Marchi, N; Najm, I; Oby, E; Uva, L; Van Boxel-Dezaire, A, 2007) |
| "The aim of this pilot study was to investigate the antiepileptic effects of a novel noninvasive stimulation technique, transcutaneous electrical stimulation (TcES) via scalp concentric ring electrodes, on pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats. ( Besio, WG; Cole, AJ; Koka, K, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 3.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| " Postnatal day 7 (P7) and P14 rat pups were injected with an exogenous provocative agent of inflammation, lipopolysaccharide (LPS), 2 h prior to limbic SE induced by either lithium-pilocarpine (LiPC) or kainic acid." | 3.74 | Inflammation exacerbates seizure-induced injury in the immature brain. ( Auvin, S; Mazarati, A; Miyamoto, J; Nakagawa, J; Sankar, R; Shin, D, 2007) |
| " To study developmental changes of this role LiCl/pilocarpine status epilepticus (SE) was induced in P12, P25 and/or adult rats." | 3.74 | Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies. ( Kubová, H; Mares, P; Rocha, L; Suchomelová, L, 2007) |
| " The anticonvulsant activity of F1,6BP was determined in rat models of acute seizures induced by pilocarpine, kainic acid, or pentylenetetrazole." | 3.74 | Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. ( Khan, FA; Lian, XY; Stringer, JL, 2007) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 3.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| "Partial limbic seizures in rodents induced by pilocarpine progress from stages I-II (mouth and facial movements; head nodding) to stage III (forelimb clonus) and then progress rapidly to stages IV-V (generalized limbic seizures; rearing, and rearing with falling) followed by status epilepticus (SE)." | 3.74 | Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. ( Feng, HJ; Kao, C; Macdonald, RL; Mathews, GC, 2008) |
| "We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats." | 3.74 | Effective treatments of prolonged status epilepticus in developing rats. ( Hasson, H; Kim, M; Moshé, SL, 2008) |
| "Morphological changes in the hippocampi of rats subjected to lithium-pilocarpine-induced status epilepticus (SE) were examined with respect to neuronal loss, inflammation, blood-brain barrier (BBB) leakage, and cell genesis." | 3.74 | Erythropoietin reduces epileptogenic processes following status epilepticus. ( Chu, K; Jung, KH; Kang, KM; Kim, HK; Kim, JH; Kim, M; Lee, SK; Lee, ST; Lim, JS; Park, HK; Roh, JK, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 3.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| " We studied the nestin distribution in the hippocampal formation of rats submitted to pilocarpine model of epilepsy." | 3.73 | Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Naffah-Mazzacoratti, MG; Scorza, CA; Scorza, FA, 2005) |
| "Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures." | 3.73 | Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. ( Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M, 2005) |
| "Multiple episodes of pilocarpine-induced status epilepticus (SE) in developing rats (P7-P9) lead to progressive epileptiform activity and severe cognitive impairment in adulthood." | 3.73 | Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; Cipelletti, B; Frassoni, C; Regondi, MC; Silva, AV; Spreafico, R, 2005) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including extensive limbic neuropathology." | 3.73 | Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2005) |
| "To extend previous work concerning diet and overt seizures in rats, we tested the hypothesis that ingestion of 10% sucrose-water could reduce seizure onset time (SOT) in rats given lithium and pilocarpine." | 3.73 | Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine. ( Galic, MA; Persinger, MA, 2005) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 3.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| "We describe the use of a clinically relevant pharmacological intervention that alters the clinical history of status epilepticus (SE)-induced spontaneous recurrent seizures (SRS) in the pilocarpine model and the possible plastic changes underlying such an effect." | 3.73 | Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats. ( Benassi, SK; Mello, LE; Pereira, HA, 2005) |
| " To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS." | 3.73 | Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide. ( Longo, B; Mello, LE; Vezzani, A, 2005) |
| " The purposes of this study were to characterize the role of adenosine receptors in modulating status epilepticus (SE) induced by pilocarpine and evaluate its neuroprotective action." | 3.73 | Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. ( Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP, 2005) |
| " In the pilocarpine and KA models, doses lower than those used in Wistar rats were able to induce status epilepticus (SE) in PG animals." | 3.73 | Proechimys guyannensis: an animal model of resistance to epilepsy. ( Arida, RM; Cavalheiro, EA; de Amorim Carvalho, R; Scorza, FA, 2005) |
| " After 2 days of infusion, rats were treated with pilocarpine to induce status epilepticus." | 3.73 | Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy. ( Buckmaster, PS; Toyoda, I, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " It has been previously reported that ectonucleotidase activities are increased in female adult rats submitted to the pilocarpine model of epilepsy." | 3.73 | Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats. ( Bonan, CD; Bruno, AN; de Paula Cognato, G; Sarkis, JJ; Vuaden, FC, 2005) |
| " In this study, we investigated whether increased generation of FR during status epilepticus would be sufficient to provoke abnormalities in mtDNA and in the expression and activity of cytochrome c oxidase (CCO), complex IV of the respiratory chain, in the chronic phase of the pilocarpine model of temporal lobe epilepsy." | 3.73 | Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine. ( Amado, D; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Nasseh, IE; Tengan, CH, 2006) |
| "To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that received pilocarpine and lovastatin (n=5)." | 3.73 | Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Rangel, P; Scorza, CA; Scorza, FA, 2005) |
| "The administration of lithium followed by pilocarpine induces status epilepticus (SE) that produces neurodegeneration and the subsequent development of spontaneous recurrent seizures." | 3.73 | Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. ( Dykstra, CM; Gurd, JW; Huo, JZ, 2006) |
| " In this study, we examined possible neuroprotective effects of uridine by administering the agent following lithium-pilocarpine induced status epilepticus." | 3.73 | Effects of uridine in models of epileptogenesis and seizures. ( Holmes, GL; Marolewski, A; Rusche, JR; Zhao, Q, 2006) |
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| "The effect of glycemic state on status epilepticus (SE) development was studied in animals of different ages, submitted to pilocarpine model of epilepsy." | 3.73 | Effect of glycemic state in rats submitted to status epilepticus during development. ( Amado, D; Carvalho, FF; Cavalheiro, EA; Cruz, JW; da Graça Naffah-Mazzacoratti, M; Fernandes, MJ; Perosa, SR; Santiago, JF; Siliano, MR, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 3.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Because OX-A is known to exert excitatory actions in the hippocampus, we hypothesized that the level of OXs targeted toward the hippocampus may be increased following status-epilepticus (SE)-induced epileptogenesis in the rat pilocarpine model of temporal lobe epilepsy." | 3.73 | Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis. ( Bezin, L; Bonnet, C; Bourgoin, N; Georges, B; Laglaine, A; Morales, A; Moulin, C; Nadam, J; Navarro, F; Pequignot, JM; Touvier, T, 2006) |
| "0 mg/kg) as well as increasing the threshold to electrically- and pentylenetetrazole-induced seizures (TID(10)s 7." | 3.73 | In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. ( Anderson, NJ; Slough, S; Watson, WP, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)." | 3.73 | The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "This work evaluates the seizure susceptibility of nai;ve female Wistar Audiogenic rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), to other pro-convulsive stimuli: transauricular electroshock (ES), pentylenetetrazole (PTZ) and pilocarpine (PILO)." | 3.72 | Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine. ( Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV, 2003) |
| "3 g/L) for 15 days before the induction of status epilepticus (SE) by lithium-pilocarpine and for 7 days after SE." | 3.72 | Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat. ( Ferrandon, A; Koning, E; Leroy, C; Nehlig, A; Rigoulot, MA, 2003) |
| "The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human temporal lobe epilepsy." | 3.72 | Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. ( Almonte, AG; Borges, K; Dingledine, R; Gearing, M; McDermott, DL; Smith, AB; Wainer, BH, 2003) |
| " We have, therefore, analysed the effects of phenytoin (100 micro m), lamotrigine (100 micro m) and valproate (600 micro m) on Na+ currents in dissociated rat hippocampal granule neurons in the pilocarpine model of chronic epilepsy." | 3.72 | Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. ( Beck, H; Elger, CE; Remy, S; Urban, BW, 2003) |
| " Here, we investigated the effects of antazoline on NMDA toxicity and current in rat hippocampal neuronal cultures, and on an in vivo model of status epilepticus." | 3.72 | Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus. ( Bockaert, J; Lafon-Cazal, M; Lerner-Natoli, M; Milhaud, D; Rondouin, G, 2003) |
| " To assess this hypothesis, the pilocarpine model of temporal lobe epilepsy was selected because an important reorganization of the glutamatergic network, which includes an aberrant sprouting of granule cell axons, neo-synaptogenesis, and dendritic spine remodeling, is well established in the dentate gyrus." | 3.72 | Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures. ( Ben-Ari, Y; Esclapez, M; Fattoum, A; Ferhat, L; Represa, A; Shirao, T, 2003) |
| "We induced status epilepticus in rats, by using lithium-pilocarpine, and then 2-12 weeks later, used whole-cell voltage-clamp to examine voltage-activated sodium currents of acutely dissociated layer V neurons." | 3.72 | Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy. ( Agrawal, N; Alonso, A; Ragsdale, DS, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 3.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| "In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine." | 3.72 | Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. ( Avedissian, M; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Longo, BM; Mello, LE; Pereira, CM, 2004) |
| " Intrahippocampal mGluR group I agonist perfusion via a microdialysis probe [1 mm (R,S)-3,5-dihydroxyphenylglycine] induced seizures and concomitant augmentations in amino acid dialysate levels." | 3.72 | In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. ( Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 3.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| "A pilocarpine-induced SRS model of epilepsy affords a reliable model of epileptogenesis suitable for evaluating new chemical entities as putative antiepileptogenics." | 3.72 | Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models. ( Lyon, A; Marone, S; Wainman, D; Weaver, DF, 2004) |
| " The anticonvulsant effects of intrahippocampally applied DA and 5-HT concentrations were evaluated against pilocarpine-induced seizures in conscious rats." | 3.72 | Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| " Here, we examine two neuroprotective agents, the noncompetitive NMDA antagonist ketamine and the dopaminergic antagonist acepromazine, for their efficacy in attenuating cognitive impairments in the lithium-pilocarpine (LI-PILO) model of rat limbic epilepsy." | 3.72 | Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model. ( McKay, BE; Persinger, MA, 2004) |
| " After pilocarpine-induced status epilepticus (SE) in mice most hilar neurons died and neuropeptide Y (NPY) immunoreactivity appeared in the dentate inner molecular layer (IML) after 10-31 days indicative of MFS." | 3.72 | Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice. ( Borges, K; Dingledine, R; McDermott, DL, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 3.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "The administration of pilocarpine (PILO) is widely recognized as resulting in an experimental model of temporal lobe epilepsy; it is characterized by induction of status epilepticus (SE) and spontaneous recurrent seizures after a latent period." | 3.72 | Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain). ( Furtado, Mde A; Garcia-Cairasco, N; Oliveira, JA; Rossetti, F, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 3.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| "To analyze whether the subcellular localization of the messenger RNAs (mRNAs) coding for the neurotrophin brain-derived neurotrophic factor (BDNF), its receptor TrkB, and the alpha and beta subunits of calcium-calmodulin-dependent kinase II (CaMKII) are modified after pilocarpine and kindled seizures." | 3.71 | Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy. ( Armellin, M; Bregola, G; Del Piccolo, P; Rodi, D; Simonato, M; Tongiorgi, E; Zucchini, S, 2002) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "This study characterized the electrophysiological and neuropathological changes in rat brains caused by pilocarpine (PILO)-induced status epilepticus (SE) of different duration." | 3.71 | Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. ( Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J, 2002) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| " Using a chromatin immunoprecipitation assay, we found that acetylation of histone H4 in rat hippocampal CA3 neurons was reduced at the glutamate receptor 2 (GluR2; GRIA2) glutamate receptor promoter but increased at brain-derived neurotrophic factor promoter P2 as soon as 3 hr after induction of status epilepticus by pilocarpine." | 3.71 | Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. ( Dingledine, R; Doherty, JJ; Huang, Y, 2002) |
| " We determined whether caspase-3 is activated by lithium-pilocarpine-induced status epilepticus in six brain regions with necrosis-induced DNA laddering." | 3.71 | Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage. ( Fujikawa, DG; Ke, X; Shinmei, SS; Trinidad, RB; Wu, A, 2002) |
| " As in patients, the consequences of the lithium-pilocarpine-induced status epilepticus (SE) are age dependent, and only a subset of 21-day-old rats will develop epilepsy." | 3.71 | Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model. ( Leroy, C; Namer, IJ; Nehlig, A; Roch, C, 2002) |
| " In adult rats, the only effective dose and agent was 125 ng V2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate." | 3.71 | Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy. ( Gulec, G; Noyan, B, 2002) |
| "Pilocarpine induced time-limited nonconvulsive status epilepticus (NCSE)." | 3.71 | An animal model of nonconvulsive status epilepticus: a contribution to clinical controversies. ( Druga, R; Hlinák, Z; Krsek, P; Kubová, H; Mares, P; Mikulecká, A, 2001) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 3.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| "Pilocarpine has been used to lower intraocular pressure (IOP) in glaucoma patients for more than 100 years." | 3.71 | Exploring the potential for subtype-selective muscarinic agonists in glaucoma. ( Brann, M; Gil, D; Kharlamb, A; Li, D; Skjaerbaek, N; Spalding, T; Trotter, C; Uldam, A; Wheeler, L; WoldeMussie, E, 2001) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 3.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 3.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 3.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 3.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both." | 3.70 | Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study. ( Calderazzo, L; Cavalheiro, EA; Sanabria, ER; Scorza, FA, 1998) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| "In the rat pilocarpine model, dendrites of DGCs revealed a generalized spine loss immediately after the acute status epilepticus induced by pilocarpine." | 3.70 | Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model. ( Isokawa, M, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 3.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| "An animal model of human complex partial status epilepticus induced by lithium chloride and pilocarpine administration was developed in our laboratory." | 3.70 | Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli. ( Druga, R; Hlinák, Z; Krsek, P; Mares, P; Mikulecká, A, 2000) |
| "Pilocarpine (PILO) induces in rats limbic seizures that become secondarily generalized and evolve to status epilepticus (SE)." | 3.69 | Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. ( Cavalheiro, EA; Leite, JP, 1995) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 3.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 3.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 3.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Flinch (pain) thresholds for electric current delivered to the feet were correlated with the amount of necrosis within the diencephalon and telencephalon for rats in which seizures had been induced by lithium and pilocarpine about two months before the testing." | 3.69 | Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats. ( Bureau, YR; Cook, LL; Peredery, O; Persinger, MA, 1997) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 3.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "The influence of seizures on phosphoinositide hydrolysis and protein kinase C activity was measured in rat hippocampus and cerebral cortex, primarily using a model in which generalized convulsive status epilepticus was induced by administration of LiCl (3 mmole/kg) 20 hr prior to pilocarpine (30 mg/kg)." | 3.68 | Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain. ( Jope, RS; Kolasa, K; Ormandy, GC; Song, L, 1992) |
| "We describe a novel model of status epilepticus produced by the focal application of bicuculline methiodide into the deep prepiriform cortex of rats pretreated with lithium chloride." | 3.68 | A rodent model of focally evoked self-sustaining status epilepticus. ( Gale, K; Pazos, A; Peterson, CJ; Vinayak, S, 1992) |
| "Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents." | 3.68 | Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Leite, JP, 1990) |
| "Elemental distribution and ultrastructure of the submandibular gland, the parotid gland and the pancreas were investigated in three suggested animal models of the disease cystic fibrosis: the chronically reserpinized rat, the chronically isoproterenol-treated rat, and the chronically pilocarpine-treated rat." | 3.67 | X-ray microanalysis of exocrine glands in animal models for cystic fibrosis. ( Müller, RM; Roomans, GM, 1985) |
| "The chronically pilocarpine-treated rat has been proposed as an animal model for the disease cystic fibrosis, a generalized exocrinopathy." | 3.67 | The chronically pilocarpine-treated rat in the study of cystic fibrosis: investigations on submandibular gland and pancreas. ( Bardon, A; Ceder, O; Kuijpers, GA; Müller, RM; Roomans, GM, 1985) |
| "The antiglaucomatous effects of Glauplex 2 and pilocarpine nitrate on alpha-chymotrypsine-induced experimental glaucoma were studied in 8 rabbits." | 3.66 | [Comparative study of the antiglaucomatous activity of Glauplex 2 and pilocarpine nitrate on alpha-chymotrypsin-induced experimental glaucoma]. ( Andermann, G; Cannet, C; de Burlet, G, 1982) |
| "Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure. ( Adelstein, E; Barbero, GJ; Martinez, JR; Quissel, D, 1975) |
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| "Status epilepticus is a neurological disorder that can result in various neuropathological conditions and presentations." | 3.01 | The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023). ( Che Has, AT, 2023) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 2.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Although longer periods of seizures consistently result in brain damage, it has previously not been clear whether brief single or intermittent seizures lead to cell death." | 2.41 | Neuronal apoptosis after brief and prolonged seizures. ( Bengzon, J; Ekdahl, CT; Lindvall, O; Mohapel, P, 2002) |
| "Epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures." | 1.91 | Upregulation of SLITRK5 in patients with epilepsy and in a rat model. ( Ai, M; Chen, H; Chen, L; Liu, Y; Mei, R; Pang, R; Xia, D; Zhang, L; Zhong, L, 2023) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 1.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 1.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy." | 1.91 | Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats. ( Diespirov, GP; Griflyuk, AV; Kalita, AD; Postnikova, TY; Sinyak, DS; Zaitsev, AV; Zubareva, OE, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 1.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 1.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "Demyelination is observed in animal models of intractable epilepsy (IE)." | 1.62 | Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study. ( Chen, Z; Gu, J; Ma, K; Niu, J; Tao, S; Wang, P; Wang, S; Wei, S; Yang, L; Ye, M; Zhang, G; Zhang, L, 2021) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 1.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "Gastrodin reduced the acute seizure severity in lithium-pilocarpine-induced seizure model." | 1.62 | Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. ( Chiu, SC; Huang, CW; Lai, MC; Liu, PY; Wu, SN; Yang, CS, 2021) |
| "Gastrodin has shown the potential as an anticonvulsant." | 1.62 | Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model. ( Han, J; Li, Y; Wang, Y; Yang, Y, 2021) |
| "Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions." | 1.62 | Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 1.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 1.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "The basic pathophysiology of epileptic seizures is still elusive, reflecting an extensive need for further research." | 1.56 | Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish. ( Abidin, SAZ; Kumari, Y; Othman, I; Paudel, YN; Shaikh, MF, 2020) |
| "Carvacrol (50 mg/kg) was injected once per day for 3 or 7 days after seizure." | 1.56 | The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kang, BS; Kang, DH; Kho, AR; Lee, SH; Lim, MS; Park, MK; Suh, SW, 2020) |
| "Epilepsy is a chronic and severe neurological disorder." | 1.51 | Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy. ( Gong, SJ; Huang, WL; Wu, ZS, 2019) |
| "Pilocarpine-treated neonatal rats showed long-term abnormal neurobehavioral parameters." | 1.51 | Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. ( Chen, SH; Jin, MF; Li, LL; Ni, H, 2019) |
| "SE frequently induces chronic recurrent seizures after an extended latency referred to as epileptogenesis." | 1.51 | Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. ( Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 1.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 1.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Inflammation is a hallmark of epileptogenic brain tissue." | 1.51 | Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain. ( Benifla, M; Ekstein, D; Eyal, S; Han, H; Mann, A; Polyak, B; Portnoy, E; Shmuel, M, 2019) |
| "Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3." | 1.48 | Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? ( Abbasova, K; Kubová, H; Mareš, P, 2018) |
| "Cortical dysplasia is the most common etiology of intractable epilepsy." | 1.48 | Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia. ( Feng, L; Wang, YL; Xiao, B; Yue, ZW, 2018) |
| "Clinical factors contributing to benzodiazepine failure in treating status epilepticus (SE) include suboptimal dosing and seizure duration." | 1.48 | Status epilepticus: Role for etiology in determining response to benzodiazepines. ( Chester, SJ; Goodkin, HP; Hawk, KM; Joshi, S; Rajasekaran, K, 2018) |
| "Comorbid depression is common in patients with epilepsy." | 1.48 | Different behavioral and pathological changes between epilepsy-associated depression and primary depression models. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2018) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 1.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| "Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures." | 1.48 | Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. ( Cavalheiro, EA; Gomes da Silva, S; Marques, MJG; Naffah-Mazzacoratti, MDG; Scorza, CA; Scorza, FA, 2018) |
| "Meanwhile, cerebral edema, as well as neuronal loss, was decreased in several brain areas in the GBC group." | 1.46 | Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. ( Gu, Y; Hu, Y; Huang, H; Huang, K; Ji, Z; Lin, Z; Pan, S; Wang, S; Wu, Y; Yang, T, 2017) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 1.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| "Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment." | 1.46 | DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy. ( Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ, 2017) |
| "In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i." | 1.46 | Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos. ( Braga, RM; da Fonsêca, DV; de Almeida, RN; de Farias, IEV; de Luna Freire Pessôa, H; de Melo, CGF; de Sousa, DP; do Amaral, IPG; Filho, MRDC; Lima, EM; Salgado, PRR, 2017) |
| "In rats with frequent severe seizures, we found a clear loss of Prox1 and NeuN expression in the dentate granule cell layer (GCL), which was confined mainly to the suprapyramidal blade of the GCL at the septal and middle regions of the septotemporal axis of the hippocampus." | 1.46 | Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus. ( Seki, T; Toda, K; Uemori, T, 2017) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 1.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| "Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation." | 1.46 | Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2017) |
| "Seizures were induced by intraperitoneal injection of pilocarpine (25mg/kg) in male rats." | 1.46 | Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. ( Choi, BY; Choi, HC; Kho, AR; Kim, JH; Lee, SH; Sohn, M; Song, HK; Suh, SW, 2017) |
| "Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available." | 1.46 | Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis. ( Liang, LP; Patel, M; Pearson, JN; Roberts, LJ; Warren, E, 2017) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| " It is concluded that chronic administration β-estradiol has anticonvulsant and neuroprotective properties which are plausibly linked to astrocytic activity." | 1.46 | Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkar Boluki, T; Sarfi, M, 2017) |
| "In addition, status epilepticus is known to enhance the transient proliferation of adult NPCs, but the c-jun expression pattern was not significantly affected." | 1.46 | c-jun is differentially expressed in embryonic and adult neural precursor cells. ( Kawashima, F; Kurata, H; Maegaki, Y; Mori, T; Saito, K, 2017) |
| "Epilepsy affects 60 million people worldwide." | 1.46 | Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice. ( Benninger, F; Griffioen, K; Gross, A; Illouz, T; Madar, R; Offen, D; Okun, E; Steiner, I, 2017) |
| "The reduction on seizure burden was associated with a limited reduction on the generation of SBDPs but was correlated with a reduction in astrocytosis, microglia activation and cell sprouting." | 1.46 | A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. ( Carlsen, J; González, MI; Lam, PM, 2017) |
| "Epilepsy is one of the most common and severe neurologic diseases." | 1.43 | Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. ( Chen, G; Chen, L; Deng, W; Jiang, G; Li, J; Mi, X; Wang, N; Wang, X; Wang, Z; Zhang, Y, 2016) |
| "Once spontaneous seizures were established, we tested the locomotor activity (open field), spatial working memory (eight-arm radial maze), and sensorimotor gating (prepulse inhibition of acoustic startle)." | 1.43 | The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions. ( Bueno-Júnior, LS; Do Val Da Silva, RA; Kandratavicius, L; Leite, JP; Lopes-Aguiar, C; Wolf, DC, 2016) |
| "In this study, we observed the seizure behavior induced by kainic acid (20 mg/kg or 30 mg/kg) or pilocarpine (350 mg/kg) in AC8 KO and wild-type mice." | 1.43 | A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice. ( Chen, X; Dong, G; Wang, H; Yun, W; Zheng, C; Zhou, X, 2016) |
| " The animals were randomized into groups and were administered one of the following treatments: saline, PILO, saline+L-α-aminoadipic acid (L-AAA; one dosage tested), PILO+L-AAA, or PILO+L-methionine sulfoximine (three dosages tested)." | 1.43 | A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats. ( Bai, XY; Chen, XM; Deng, DP; Li, SC; Liu, YX; Pan, XH; Sun, HL; Wang, CH; Wang, CY; Zhang, XL; Zhu, W, 2016) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 1.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Sham-treated pilocarpine rats but not sunitinib-treated pilocarpine rats had significantly smaller hippocampi." | 1.43 | Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy? ( Avoli, M; Benini, R; Khoja, Z; Roth, R; Wintermark, P, 2016) |
| "The pilocarpine model has been recognized as an animal model of TLE." | 1.43 | Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy. ( Costa, AP; de Mello, N; Farina, M; Gonçalves, FM; Leal, RB; Lopes, MW; Lopes, SC; Prediger, RD; Santos, DB; Walz, R, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Temporal lobe epilepsy is a common and challenging clinical problem, and its pathophysiological mechanisms remain unclear." | 1.43 | More Docked Vesicles and Larger Active Zones at Basket Cell-to-Granule Cell Synapses in a Rat Model of Temporal Lobe Epilepsy. ( Buckmaster, PS; Thind, K; Yamawaki, R, 2016) |
| "Pilocarpine was administered by a ramp-up dosing protocol that allows determining interindividual differences in susceptibility to the convulsant." | 1.43 | The pilocarpine model of temporal lobe epilepsy: Marked intrastrain differences in female Sprague-Dawley rats and the effect of estrous cycle. ( Bankstahl, M; Brandt, C; Klee, R; Löscher, W; Töllner, K, 2016) |
| "Levetiracetam (LEV) is a novel anti-epileptic drug (AED) used to treat partial seizures and idiopathic generalized epilepsy." | 1.43 | Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats. ( Ge, YX; Lin, YY; Liu, XY; Tian, XZ, 2016) |
| "Neuroinflammation is known to be involved in epileptogenesis with unclear mechanisms." | 1.42 | Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. ( Hung, SW; Hung, YW; Lai, MT; Lee, TS; Lin, YY; Shih, YH; Wong, LK; Wu, YC, 2015) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "Steroid-induced ocular hypertension (SIOH) is associated with topical and systemic use of steroids." | 1.42 | Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs. ( Agarwal, P; Agarwal, R; Ismail, NM; Kannan Kutty, M; Kapitonova, MY; Razali, N; Salmah Bakar, N; Smirnov, A, 2015) |
| "However, whether ENT1 plays a role in epileptic seizure that involves elevated glutamatergic neurotransmission is unknown." | 1.42 | ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission. ( Chen, G; Chen, Y; Fang, M; Liu, J; Luo, J; Lv, Y; Wang, J; Wang, K; Wang, X; Xu, P; Xu, Z; Zhang, J; Zhang, Y, 2015) |
| "In pilocarpine-treated animals, β-AR-mediated LTP was strongly reduced in the distal subiculum." | 1.42 | Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy. ( Bartsch, JC; Behr, J; Gilling, KE; Grosser, S; Heinemann, U; Hollnagel, JO, 2015) |
| " To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing strategy to produce spontaneous recurring seizures in immunodeficient NodScid mice." | 1.42 | Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice. ( Ahn, S; Chung, S; Cunningham, M; Iskandar, D; Kim, KS; Kim, Y; Leung, A; Luna, MJ; Savvidis, G, 2015) |
| "Only 29% of LEV-treated animals had seizures compared to all controls following a latent period that was similar in duration." | 1.42 | The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M, 2015) |
| "However, its role in seizures and postictal outcomes is still not fully understood." | 1.42 | PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. ( Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Epilepsy is a common neurological disorder." | 1.42 | Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats. ( Li, M; Wang, S; Wang, X; Xu, X; Yang, X; Zhang, Y, 2015) |
| "Temporal lobe epilepsy is often presented by medically intractable recurrent seizures due to dysfunction of temporal lobe structures, mostly the temporomesial structures." | 1.42 | Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. ( Eslamizade, MJ; Ghadiri, T; Gorji, A; Hadjighassem, M; Modarres Mousavi, SM; Saffarzadeh, F, 2015) |
| "TRPC6 knockdown increased seizure susceptibility, excitability ratio and paired-pulse inhibition in the dentate gyrus (DG) of normal animals." | 1.42 | The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. ( Kang, TC; Kim, YJ, 2015) |
| "The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests." | 1.42 | Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy. ( Frolova, EV; Kalemenev, SV; Kim, KKh; Lavrentyeva, VV; Lukomskaya, NY; Magazanik, LG; Sizov, VV; Zaitsev, AV; Zubareva, OE, 2015) |
| "In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα)." | 1.42 | Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats. ( Amorim, BO; Brito, JG; Covolan, L; de Morais, DG; deAlmeida, AC; Ferreira, E; Hamani, C; Nobrega, JN; Nunes, DP; Rodrigues, AM, 2015) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| "In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 1.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
| "Status epilepticus affected male and female rats differentially." | 1.40 | Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup. ( Beltrán-Parrazal, L; López-Meraz, ML; Manzo, J; Medel-Matus, JS; Morgado-Valle, C; Pérez-Estudillo, C, 2014) |
| "Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus." | 1.40 | Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. ( Griesbach, G; Jentsch, JD; Mazarati, A; Pineda, E; Sankar, R; Shin, D, 2014) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 1.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Intraocular pressure was controlled by intracameral cannulation of mouse eyes while imaging using spectral-domain optical coherence tomography (SD-OCT)." | 1.40 | Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT. ( Chiu, SJ; Farsiu, S; Gonzalez, P; Li, G; Lütjen-Drecoll, E; Overby, DR; Stamer, WD, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Lmx1b(f/f/p) mice had a lower seizure threshold and increased seizure-induced mortality." | 1.40 | Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. ( Buchanan, GF; Hajek, MA; Murray, NM; Richerson, GB, 2014) |
| "Proglumide (Pgm) is a known cholecystokinin (CCK) antagonist and any changes in the level of CCK and in the number of CCK receptors has been linked with SE." | 1.40 | Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus. ( Ahmad, M; Wadaan, MA, 2014) |
| "Seizures have been shown to upregulate the expression of numerous extracellular matrix molecules." | 1.40 | Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model. ( Arriaga-Avila, V; Guevara-Guzmán, R; Landgrave-Gómez, J; Mercado-Gómez, O; Nebreda-Corona, A, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| "Diabetes can exacerbate seizures and worsen seizure-related brain damage." | 1.39 | Pregabalin attenuates excitotoxicity in diabetes. ( Cheng, JT; Huang, CC; Huang, CW; Lai, MC; Tsai, JJ; Wu, SN, 2013) |
| " Luteolin did not exhibit any consistent anti- or pro-convulsant actions after single dosing in the 6 Hz (0." | 1.39 | Anticonvulsant screening of luteolin in four mouse seizure models. ( Borges, K; Shaikh, MF; Tan, KN, 2013) |
| "The 6-Hz psychomotor seizure model in mice is increasingly been used as a model for differentiation of anticonvulsant activity during development of new antiepileptic drugs (AEDs)." | 1.39 | Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model. ( Bankstahl, JP; Bankstahl, M; Löscher, W, 2013) |
| "Pilocarpine-induced seizure increased p47 immunofluorescence in the plasma membrane of hippocampal neurons at 12h post-insult and apocynin treatment prevented this increase." | 1.39 | Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death. ( Choi, BY; Choi, HC; Chung, TN; Jang, BG; Kim, HS; Kim, JH; Sohn, M; Song, HK; Suh, SW, 2013) |
| "The duration of sustained seizures (SS) plays a crucial role in the occurrence of spontaneous recurrent seizures (SRS) in experimental animals." | 1.38 | The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats. ( Huang, PY; Hung, YW; Kuo, TB; Lee, TS; Lin, YY; Shih, YH; Yang, DI; Yiu, CH, 2012) |
| "Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus." | 1.38 | Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. ( Abdallah, DM; Al-Shorbagy, MY; El Sayeh, BM, 2012) |
| "Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management." | 1.38 | Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. ( Abraham, PM; Antony, S; Balakrishnan, S; Mathew, J; Paulose, CS, 2012) |
| "To characterize the microbead-induced ocular hypertension (OHT) mouse model and investigate its potential use for preclinical screening and evaluation of ocular hypotensive agents, we tested the model's responses to major antiglaucoma drugs." | 1.38 | Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma. ( Chen, DF; Chen, H; Cho, KS; Guo, W; Luo, G; Pang, IH; Wang, WH; Yang, Q; Yu, D, 2012) |
| "First, we repeatedly determined the PTZ seizure threshold by i." | 1.38 | Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. ( Brandt, C; Löscher, W; Rattka, M, 2012) |
| " We used male NMRI mice (28-32 g) and first established the dose-response relationship for pilocarpine (250-400 mg/kg; ip) to induce status epilepticus (SE)." | 1.38 | Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. ( Kaminski, RM; Kumar, G; Mazzuferi, M; Rospo, C, 2012) |
| "The mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2." | 1.38 | A strength exercise program in rats with epilepsy is protective against seizures. ( Arida, RM; Cassilhas, R; Cavalheiro, EA; de Almeida, AA; de Mello, MT; Fernandes, J; Novaes Gomes, FG; Peixinho-Pena, LF; Scorza, FA; Venancio, DP, 2012) |
| "The comorbidity between epilepsy and Alzheimer's disease (AD) is a topic of growing interest." | 1.38 | Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. ( Cai, H; Cai, Y; Deng, SH; Laferla, FM; Luo, XG; Oddo, S; Patrylo, PR; Rose, GM; Shelton, J; Yan, XX, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 1.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Acquired epilepsy is associated with long-term neuronal plasticity changes in the hippocampus resulting in the expression of spontaneous recurrent seizures." | 1.37 | Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Rafiq, A; Sombati, S, 2011) |
| "Pulpitis was induced with bacterial lipolysaccharide in rat incisors dental pulp." | 1.37 | Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp. ( Borda, E; De Couto Pita, A; Orman, B; Sterin-Borda, L, 2011) |
| "Decreased seizure frequency (≥ 50%) or interruption of status epilepticus was observed in the majority of the subjects, regardless of the underlying pathology." | 1.37 | Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. ( Alexopolous, A; Ciusani, E; Freri, E; Granata, T; Janigro, D; Marchi, N; Puvenna, V; Ragona, F; Teng, Q, 2011) |
| "Status epilepticus was induced in postnatal day 20 Sprague-Dawley rat pups with the chemoconvulsant lithium-pilocarpine and brain tissue was examined with Fluoro-Jade B." | 1.37 | Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus. ( Dudek, FE; Ekstrand, JJ; Pouliot, W; Scheerlinck, P, 2011) |
| "To reveal putative seizure-induced changes in blood-brain barrier integrity, we performed gadolinium-enhanced magnetic resonance scans on a 7." | 1.37 | A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier. ( Bankstahl, JP; Bankstahl, M; Ding, XQ; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Wanek, T, 2011) |
| "Temporal lobe epilepsy is one of the most common types of epilepsy." | 1.37 | Improvement of the pilocarpine epilepsy model in rat using bone marrow stromal cell therapy. ( Abdanipour, A; Mirnajafi-Zadeh, J; Tiraihi, T, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "However, whether STAT3 controls astrogliosis in epilepsy is not clear." | 1.37 | Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. ( Chen, Y; Fang, M; Lei, X; Li, Y; Wang, L; Wang, X; Xie, Y; Xu, P; Xu, Z; Xue, T; Zhang, J; Zhang, Z, 2011) |
| " Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin." | 1.37 | Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. ( Tawfik, MK, 2011) |
| "Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear." | 1.37 | Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. ( Hu, XL; Liu, YY; Mei, L; Tan, GH; Xiong, ZQ; Yin, DM, 2011) |
| "Six pilocarpine-treated Wistar rats exhibiting spontaneous recurrent seizures and nine control rats were studied with PET using [(18)F]-fallypride, a high-affinity dopamine D(2/3) receptor ligand." | 1.36 | In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy. ( Bartenstein, P; Buchholz, HG; Cumming, P; Debus, F; Dupont, E; Fellgiebel, A; Heimann, A; Landvogt, C; Luhmann, HJ; Potschka, H; Schreckenberger, M; Tillmanns, J; Werhahn, KJ; Yakushev, IY, 2010) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 1.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale." | 1.36 | Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. ( Costa-Ferro, ZS; Cunha, FB; DaCosta, JC; Machado, DC; Pedroso, MF; Ribeiro-dos-Santos, R; Soares, MB; Vitola, AS; Xavier, LL, 2010) |
| "These findings suggest that spontaneous seizures and associated ERK activation could contribute to the proliferation of radial glia-like NPCs in this epilepsy model." | 1.36 | Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy. ( Houser, CR; Li, Y; Peng, Z; Xiao, B, 2010) |
| " Based on pharmacokinetic studies with bumetanide, which showed extremely rapid elimination and low brain penetration of this drug in rats, bumetanide was administered systemically with different dosing protocols, including continuous intravenous infusion." | 1.36 | Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. ( Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M, 2010) |
| "It has long been held that chronic seizures cause blood-brain barrier (BBB) damage." | 1.36 | Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity. ( Bawa, H; Desai, NK; Fan, Q; Ghosh, C; Janigro, D; Marchi, N; Masaryk, TK; Nguyen, MT; Rasmussen, P; Teng, Q, 2010) |
| "The development of epilepsy is often associated with marked changes in central nervous system cell structure and function." | 1.36 | Proteomic profiling of the epileptic dentate gyrus. ( Cao, R; Cho, HY; Choi, YS; Dziema, H; Jung, YJ; Li, A; Obrietan, K, 2010) |
| "We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring." | 1.36 | Seizures during pregnancy modify the development of hippocampal interneurons of the offspring. ( Amado, D; Cabral, FR; Cavalheiro, EA; Cossa, AC; da Silva, AV; de Lima, E; de Oliveira, EM; do Vale, TG; Lima, DC; Naffah-Mazzacoratti, Mda G; Torres, LB, 2010) |
| "PTZ injection induced clonic seizures in MCH(1)R-WT mice but failed to induce them in MCH(1)R-KO mice." | 1.36 | Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. ( Civelli, O; Gohil, K; Okumura, SM; Parks, GS, 2010) |
| "Pilocarpine-induced SE was chosen as a model to generate chronic epileptic rats." | 1.36 | Changes in the numbers and distribution of calretinin in the epileptic rat hippocampus. ( Abuhamed, MM; Alsharafi, WA; Bo, X; Jing, L; Long, L; Zhi, S; Zhiguo, W, 2010) |
| "In the remaining animals that exhibited seizures, KB-R7943 pretreatment delayed the onset of seizures and status epilepticus, and reduced seizure severity." | 1.36 | Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. ( Martinez, Y; N'Gouemo, P, 2010) |
| "We report that brief seizures evoked by electroshock produced an increase in the number of NPY neurons in the dentate hilus and retrosplenial cortex, an effect that lasted 10 weeks." | 1.36 | Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis. ( Cardoso, A; Carvalho, LS; Freitas-da-Costa, P; Lukoyanov, NV, 2010) |
| "Pilocarpine was used to induce SE in OPN(-/-) and OPN(+/+) mice to compare seizure susceptibility, neuropathological markers including real time PCR for inflammatory genes, and osteopontin immunohistochemistry." | 1.35 | Characterization of osteopontin expression and function after status epilepticus. ( Borges, K; Denhardt, DT; Dingledine, R; Gearing, M; Kotloski, R; Rittling, S; Sorensen, ES, 2008) |
| "Edaravone (MCI-186) is a newly developed antioxidative radical scavenger for the treatment of acute cerebral infarction, exerting neuroprotective effects against ischemic insult." | 1.35 | Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. ( Abe, T; Anan, M; Fujiki, M; Kamida, T; Kobayashi, H; Ooba, H, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 1.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Ketamine-treated seized rats were healthier than acepromazine-treated seized rats or normal rats." | 1.35 | Large differences in blood measures, tissue weights, and focal areas of damage 1 year after postseizure treatment with acepromazine or ketamine. ( Blomme, CG; Dupont, MJ; George, KR; Mazzuchin, A; Persinger, MA; Rico, T; St-Pierre, LS; Stewart, LS, 2009) |
| "Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood." | 1.35 | Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 1.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 1.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Temporal lobe epilepsy is common and difficult to treat." | 1.35 | Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Zhang, W, 2009) |
| "Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function and susceptibility to arrhythmias have not been directly investigated." | 1.35 | Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. ( Bealer, SL; Little, JG; Metcalf, CS; Poelzing, S, 2009) |
| " In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies." | 1.35 | Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. ( Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009) |
| "Seizures were evoked in freely moving rats by intrahippocampal microperfusion, via a microdialysis probe, of the muscarinic receptor agonist pilocarpine (10mM), GABA(A) receptor antagonist picrotoxin (100microM) or group I metabotropic glutamate receptor agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) (1mM)." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "Epilepsy is a major public health problem affecting nearly 50 million people world wide." | 1.35 | Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. ( El Elshamy, KA; Elwakkad, AS; Sibaii, H, 2008) |
| "We studied IS in two seizure models; pilocarpine-induced status epilepticus and recurrent flurothyl models." | 1.34 | Effect of interictal spikes on single-cell firing patterns in the hippocampus. ( Holmes, GL; Lenck-Santini, PP; Zhao, Q; Zhou, JL, 2007) |
| "Convulsive status epilepticus is associated with subsequent hippocampal damage and development of mesial temporal sclerosis in a subset of individuals." | 1.34 | Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. ( Bamidele, A; Begum, S; Choy, M; de Castro, SC; Gadian, DG; Greene, ND; Leung, KY; Lythgoe, MF; Scott, RC; Wait, R, 2007) |
| " In order to ensure the occurrence of status epilepticus (SE) and decrease mortality, individual dosing of pilocarpine was performed by ramping up the dose until onset of SE." | 1.34 | Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice. ( Gröticke, I; Hoffmann, K; Löscher, W, 2007) |
| "In pilocarpine-treated rats the subiculum showed cell loss of about 30%." | 1.33 | Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy. ( Behr, J; Heinemann, U; Kivi, A; Knopp, A; Wozny, C, 2005) |
| "Drug design in epilepsy is now tackling a new target--epileptogenesis." | 1.33 | A spontaneous recurrent seizure bioassay for anti-epileptogenic molecules. ( Lyon, AP; Marone, S; Wainman, D; Weaver, DF, 2005) |
| "SNC80 (60 mg/kg) also decreased overall seizure severity." | 1.33 | The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. ( Bausch, SB; Garland, JP; Yamada, J, 2005) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 1.33 | Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model. ( Bracey, JM; Churn, SB; Holbert, WH; Lee, AT; Singleton, MW, 2005) |
| "Ketamine-treated pilocarpine-seized rats and normal rats were exposed continuously either to a complex sequence magnetic field or to control conditions during the acquisition of a radial arm maze task for 8 consecutive days." | 1.33 | Weak, physiologically patterned magnetic fields do not affect maze performance in normal rats, but disrupt seized rats normalized with ketamine: possible support for a neuromatrix concept? ( McKay, BE; Persinger, MA, 2006) |
| "Pilocarpine-treated animals represent an established model of mesial temporal lobe epilepsy." | 1.33 | Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. ( Avoli, M; Baldelli, E; Biagini, G; D'Antuono, M; D'Arcangelo, G; Tancredi, V, 2005) |
| "Among the causes for sudden death in epilepsy, cardiac dysfunction has been an area of interest." | 1.33 | [Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?]. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Gomes, PA; Scorza, FA, 2005) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its pathophysiology remains unclear." | 1.33 | Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kumar, SS, 2006) |
| "Herbimycin-treated animals developed spontaneous recurrent seizures, as did control animals, with a similar latency for the appearance of the first seizure and similar seizure frequency." | 1.33 | Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy. ( Mello, LE; Queiroz, CM, 2006) |
| "Cycloheximide-pilocarpine-treated animals, in contrast, had CGRP and neo-Timm staining similar to controls." | 1.32 | Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus. ( Chadi, G; Covolan, L; Longo, B; Mello, LE, 2003) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its underlying mechanisms are unclear." | 1.32 | Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kobayashi, M; Wen, X, 2003) |
| "Pilocarpine treatment induced downregulation of (M(1)+M(2)) muscarinic receptors and reduced the dissociation constants of (M(1)+M(2)) muscarinic and D(2) dopaminergic receptors, suggesting that these systems exert opposite effects on the regulation of convulsive activity." | 1.32 | Pilocarpine-induced seizures in adult rats: monoamine content and muscarinic and dopaminergic receptor changes in the striatum. ( Bezerra Felipe, CF; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Viana, GS, 2003) |
| "Prolonged seizures in early childhood are associated with an increased risk of development of epilepsy in later life." | 1.32 | Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. ( Brooks-Kayal, AR; Hsu, FC; Raol, YS; Zhang, G, 2004) |
| "It is known that evoked seizures can increase neurogenesis in the dentate gyrus in adult rats." | 1.32 | Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis. ( Akman, C; Cha, BH; Holmes, GL; Liu, X; Silveira, DC, 2004) |
| "Many animals developed seizures of varying severity and length." | 1.32 | Neuropathology of seizures in the immature rabbit. ( Brucklacher, R; Housman, C; Towfighi, J; Vannucci, RC, 2004) |
| "In pilocarpine-treated animals, the normal diffuse labeling of the delta subunit in the dentate molecular layer was decreased by 4 d after status epilepticus (latent period) and remained low throughout the period of chronic seizures." | 1.32 | Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. ( Houser, CR; Huang, CS; Mody, I; Peng, Z; Stell, BM, 2004) |
| " In addition, long-term administration of high-dose topiramate in the normal developing rat brain does not appear to impair cognitive performance." | 1.31 | Effect of topiramate following recurrent and prolonged seizures during early development. ( Cha, BH; Holmes, GL; Hu, Y; Liu, X; Silveira, DC, 2002) |
| "A battery of three tests, catalepsy (haloperidol-induced) augmentation, amphetamine-induced stereotypy antagonism and conditioned avoidance response were used." | 1.31 | Effect of muscarinic receptor agonists on animal models of psychosis. ( Karan, RS; Pandhi, P; Ravishankar, P, 2000) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 1.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "Spontaneous behavioral seizures were observed in BDNF-infused rats (8/32; 25%) but not in controls (0/20; 0%)." | 1.31 | Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. ( Croll, SD; Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 1.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "In pilocarpine-treated rats, however, kappa receptor-mediated effects were seen in both ventral and more dorsal sections." | 1.30 | Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. ( Chavkin, C; Simmons, ML; Terman, GW, 1997) |
| "Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats." | 1.30 | Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. ( Fike, JR; Lowenstein, DH; Parent, JM; Tada, E, 1999) |
| "The numbers of Level 5 (Racine) seizures, inferred by the rat's rearing, rapid forelimb clonus, and falling, were statistically more frequent for the frequency-modulated (Thomas) pattern when its pixel duration and interstimulus presentation were 3 msec." | 1.30 | Facilitation of seizures in limbic epileptic rats by complex 1 microTesla magnetic fields. ( Belanger-Chellew, G; Persinger, MA, 1999) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 1.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 1.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "Organized electrographic seizure activity developed just prior to the onset of behavioral forelimb clonus and appeared to originate from ventral forebrain in the vicinity of the ventral pallidum and/or nucleus accumbens." | 1.27 | The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. ( Clifford, DB; Collins, RC; Maniotis, A; Olney, JW; Zorumski, CF, 1987) |
| "An initial response of ocular hypertension followed by hypotension was observed in all of the animals tested." | 1.27 | Laser-induced glaucoma in rabbits. ( Gherezghiher, T; Koss, MC; March, WF; Nordquist, RE, 1986) |
| "Hemorrhagic atelectasis was successfully produced in newborn rabbits by pharmacologically narrowing airways leading to alveoli ventilated with oxygen-enriched gas." | 1.25 | A new model for neonatal pulmonary hemorrhage research. ( Kotas, RV; Mims, LC; Trainor, EJ; Wells, TJ; Wiles, CL, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (1.98) | 18.7374 |
| 1990's | 38 (3.41) | 18.2507 |
| 2000's | 326 (29.29) | 29.6817 |
| 2010's | 613 (55.08) | 24.3611 |
| 2020's | 114 (10.24) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 4 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Henkel, ND | 1 |
| Smail, MA | 1 |
| Wu, X | 2 |
| Enright, HA | 1 |
| Fischer, NO | 1 |
| Eby, HM | 1 |
| McCullumsmith, RE | 1 |
| Shukla, R | 1 |
| Wang, Y | 10 |
| Yuan, J | 3 |
| Yu, X | 5 |
| Liu, X | 9 |
| Tan, C | 1 |
| Chen, Y | 13 |
| Xu, T | 4 |
| Righes Marafiga, J | 1 |
| Vendramin Pasquetti, M | 1 |
| Calcagnotto, ME | 2 |
| Lee, WJ | 1 |
| Moon, J | 5 |
| Lim, JA | 4 |
| Jeon, D | 7 |
| Yoo, JS | 2 |
| Park, DK | 5 |
| Han, D | 2 |
| Lee, ST | 9 |
| Jung, KH | 9 |
| Park, KI | 4 |
| Lee, SK | 9 |
| Chu, K | 9 |
| Song, LJ | 1 |
| Zhang, H | 12 |
| Qu, XP | 1 |
| Jin, JG | 1 |
| Wang, C | 3 |
| Jiang, X | 1 |
| Gao, L | 1 |
| Li, G | 3 |
| Wang, DL | 1 |
| Shen, LL | 1 |
| Liu, B | 1 |
| Wang, P | 1 |
| Ma, K | 1 |
| Yang, L | 4 |
| Zhang, G | 4 |
| Ye, M | 1 |
| Wang, S | 8 |
| Wei, S | 1 |
| Chen, Z | 5 |
| Gu, J | 4 |
| Zhang, L | 5 |
| Niu, J | 1 |
| Tao, S | 1 |
| Vigier, A | 1 |
| Partouche, N | 1 |
| Michel, FJ | 1 |
| Crépel, V | 2 |
| Marissal, T | 1 |
| Pale, S | 1 |
| Neteydji, S | 1 |
| Taiwe, GS | 1 |
| Kouemou Emegam, N | 1 |
| Bum, EN | 1 |
| Postnikova, TY | 4 |
| Diespirov, GP | 3 |
| Amakhin, DV | 3 |
| Vylekzhanina, EN | 1 |
| Soboleva, EB | 1 |
| Zaitsev, AV | 12 |
| Dyomina, AV | 2 |
| Kovalenko, AA | 3 |
| Zakharova, MV | 1 |
| Griflyuk, AV | 3 |
| Smolensky, IV | 2 |
| Antonova, IV | 1 |
| Pascoal, VDB | 2 |
| Marchesini, RB | 1 |
| Athié, MCP | 1 |
| Matos, AHB | 1 |
| Conte, FF | 1 |
| Pereira, TC | 1 |
| Secolin, R | 1 |
| Gilioli, R | 1 |
| Malheiros, JM | 4 |
| Polli, RS | 2 |
| Tannús, A | 4 |
| Covolan, L | 10 |
| Pascoal, LB | 1 |
| Vieira, AS | 1 |
| Cavalheiro, EA | 58 |
| Cendes, F | 1 |
| Lopes-Cendes, I | 3 |
| Nagib, MM | 1 |
| Zhang, S | 5 |
| Yasmen, N | 1 |
| Li, L | 4 |
| Hou, R | 1 |
| Yu, Y | 1 |
| Boda, VK | 1 |
| Wu, Z | 1 |
| Jiang, J | 5 |
| Bierlein, ER | 1 |
| Smith, JC | 1 |
| Van Hook, MJ | 1 |
| Aourz, N | 4 |
| Van Leuven, F | 1 |
| Allaoui, W | 1 |
| Van Eeckhaut, A | 1 |
| De Bundel, D | 3 |
| Smolders, I | 14 |
| Cui, H | 1 |
| Zhang, W | 6 |
| Fábera, P | 1 |
| Uttl, L | 1 |
| Kubová, H | 12 |
| Tsenov, G | 3 |
| Mareš, P | 11 |
| Bera, A | 1 |
| Srivastava, A | 1 |
| Dubey, V | 2 |
| Dixit, AB | 2 |
| Tripathi, M | 2 |
| Sharma, MC | 1 |
| Lalwani, S | 1 |
| Chandra, PS | 2 |
| Banerjee, J | 2 |
| Mallmann, MP | 1 |
| Mello, FK | 3 |
| Neuberger, B | 2 |
| da Costa Sobral, KG | 1 |
| Fighera, MR | 7 |
| Royes, LFF | 3 |
| Furian, AF | 8 |
| Oliveira, MS | 10 |
| Seo, GY | 1 |
| Neal, ES | 2 |
| Han, F | 1 |
| Vidovic, D | 1 |
| Nooru-Mohamed, F | 1 |
| Dienel, GA | 1 |
| Sullivan, MA | 1 |
| Borges, K | 13 |
| Godale, CM | 1 |
| Parkins, EV | 1 |
| Gross, C | 1 |
| Danzer, SC | 6 |
| Zhang, J | 6 |
| Qiao, N | 2 |
| Wang, J | 8 |
| Li, B | 2 |
| Shishmanova-Doseva, M | 4 |
| Atanasova, D | 2 |
| Ioanidu, L | 2 |
| Uzunova, Y | 3 |
| Atanasova, M | 3 |
| Peychev, L | 3 |
| Tchekalarova, J | 4 |
| Qian, X | 1 |
| Ding, JQ | 1 |
| Zhao, X | 1 |
| Sheng, XW | 1 |
| Wang, ZR | 1 |
| Yang, QX | 1 |
| Zheng, JJ | 1 |
| Zhong, JG | 1 |
| Zhang, TY | 1 |
| He, SQ | 1 |
| Ji, WD | 1 |
| Zhang, M | 3 |
| Komori, R | 2 |
| Matsuo, T | 2 |
| Yokota-Nakatsuma, A | 2 |
| Hashimoto, R | 1 |
| Kubo, S | 1 |
| Kozawa, C | 1 |
| Kono, T | 1 |
| Ishihara, Y | 3 |
| Itoh, K | 4 |
| Nakatani, M | 1 |
| Ochi, S | 1 |
| Matsumoto, J | 1 |
| Takata, F | 2 |
| Dohgu, S | 2 |
| Yue, J | 3 |
| Xu, R | 1 |
| Yin, C | 1 |
| Yang, H | 5 |
| Zhang, C | 5 |
| Zhao, D | 1 |
| Pohlentz, MS | 1 |
| Müller, P | 1 |
| Cases-Cunillera, S | 1 |
| Opitz, T | 6 |
| Surges, R | 2 |
| Hamed, M | 1 |
| Vatter, H | 2 |
| Schoch, S | 9 |
| Becker, AJ | 10 |
| Pitsch, J | 9 |
| Whitebirch, AC | 2 |
| LaFrancois, JJ | 3 |
| Jain, S | 2 |
| Leary, P | 1 |
| Santoro, B | 3 |
| Siegelbaum, SA | 3 |
| Scharfman, HE | 12 |
| Kumar, H | 2 |
| Katyal, J | 2 |
| Joshi, D | 1 |
| Gupta, YK | 1 |
| Pacheco, ALD | 1 |
| de Melo, IS | 1 |
| de Araujo Costa, M | 1 |
| Amaral, MMC | 1 |
| de Gusmão Taveiros Silva, NK | 1 |
| Santos, YMO | 1 |
| Gitaí, DLG | 1 |
| Duzzioni, M | 4 |
| Borbely, AU | 1 |
| Silva, RS | 1 |
| Donatti, ALF | 1 |
| Mestriner, L | 1 |
| Fuzo, CA | 1 |
| Cummings, RD | 1 |
| Garcia-Cairasco, N | 10 |
| Dias-Baruffi, M | 1 |
| de Castro, OW | 1 |
| Singh, S | 1 |
| Singh, TG | 1 |
| Georgieva, K | 2 |
| Nenchovska, Z | 2 |
| Hyder, SK | 3 |
| Ghosh, A | 3 |
| Forcelli, PA | 3 |
| García-García, L | 6 |
| Gomez, F | 4 |
| Delgado, M | 6 |
| Fernández de la Rosa, R | 5 |
| Pozo, MÁ | 6 |
| Uczay, M | 1 |
| Pflüger, P | 3 |
| Picada, JN | 3 |
| de Oliveira, JDM | 1 |
| da SilvaTorres, IL | 1 |
| Medeiros, HR | 1 |
| Vendruscolo, MH | 1 |
| von Poser, G | 1 |
| Pereira, P | 3 |
| de Labra, C | 1 |
| Cudeiro, J | 1 |
| Rivadulla, C | 1 |
| Liu, Y | 17 |
| Ai, M | 1 |
| Xia, D | 1 |
| Chen, H | 8 |
| Pang, R | 1 |
| Mei, R | 1 |
| Zhong, L | 1 |
| Chen, L | 8 |
| Cumbres-Vargas, IM | 1 |
| Zamudio, SR | 1 |
| Pichardo-Macías, LA | 2 |
| Ramírez-San Juan, E | 1 |
| Suleymanova, EM | 4 |
| Karan, AA | 1 |
| Borisova, MA | 2 |
| Volobueva, MN | 1 |
| Bolshakov, AP | 1 |
| Lévesque, M | 10 |
| Etter, G | 1 |
| Williams, S | 1 |
| Avoli, M | 22 |
| Concepcion, FA | 1 |
| Ekstrom, NA | 1 |
| Khan, MN | 1 |
| Estes, OO | 1 |
| Poolos, NP | 2 |
| Hernández-Martín, N | 1 |
| Silván, Á | 2 |
| Rosa, RF | 1 |
| Bascuñana, P | 4 |
| Che Has, AT | 1 |
| Szep, D | 1 |
| Dittrich, B | 1 |
| Gorbe, A | 1 |
| Szentpeteri, JL | 1 |
| Aly, N | 1 |
| Jin, M | 1 |
| Budan, F | 1 |
| Sik, A | 1 |
| McCoy, AM | 1 |
| Prevot, TD | 1 |
| Sharmin, D | 1 |
| Cook, JM | 1 |
| Sibille, EL | 1 |
| Lodge, DJ | 1 |
| Barnett, A | 1 |
| Lisgaras, CP | 1 |
| Roy, A | 1 |
| Pandey, S | 1 |
| Kumar Gupta, Y | 1 |
| Burke, CT | 1 |
| Vitko, I | 1 |
| Straub, J | 1 |
| Nylund, EO | 1 |
| Gawda, A | 1 |
| Blair, K | 1 |
| Sullivan, KA | 1 |
| Ergun, L | 1 |
| Ottolini, M | 1 |
| Patel, MK | 1 |
| Perez-Reyes, E | 1 |
| Wu, Y | 4 |
| Yang, K | 2 |
| Yan, L | 1 |
| Feng, L | 7 |
| Zubareva, OE | 4 |
| Sinyak, DS | 1 |
| Kalita, AD | 1 |
| Shao, M | 1 |
| Yu, H | 1 |
| Santhakumar, V | 1 |
| Yu, J | 3 |
| Liang, C | 2 |
| Wu, K | 1 |
| Hou, Z | 1 |
| Wang, L | 11 |
| Liu, S | 2 |
| Koska, I | 2 |
| van Dijk, RM | 2 |
| Seiffert, I | 2 |
| Di Liberto, V | 2 |
| Möller, C | 2 |
| Palme, R | 2 |
| Hellweg, R | 2 |
| Potschka, H | 5 |
| Wu, ZS | 1 |
| Huang, WL | 1 |
| Gong, SJ | 1 |
| Lenz, M | 1 |
| Shimon, MB | 1 |
| Benninger, F | 2 |
| Neufeld, MY | 1 |
| Shavit-Stein, E | 1 |
| Vlachos, A | 1 |
| Maggio, N | 2 |
| Tannich, F | 1 |
| Tlili, A | 1 |
| Pintard, C | 1 |
| Chniguir, A | 1 |
| Eto, B | 1 |
| Dang, PM | 1 |
| Souilem, O | 1 |
| El-Benna, J | 1 |
| Moura, DMS | 1 |
| de Sales, IRP | 1 |
| Brandão, JA | 1 |
| Costa, MR | 1 |
| Queiroz, CM | 6 |
| Zhang, Y | 28 |
| Zhu, W | 3 |
| Wang, Q | 5 |
| Cui, Y | 3 |
| Pan, X | 1 |
| Gao, X | 1 |
| Sun, H | 4 |
| Alachkar, A | 1 |
| Azimullah, S | 1 |
| Ojha, SK | 1 |
| Beiram, R | 1 |
| Łażewska, D | 1 |
| Kieć-Kononowicz, K | 1 |
| Sadek, B | 1 |
| Foresti, ML | 4 |
| Arisi, GM | 4 |
| Campbell, JJ | 1 |
| Mello, LE | 25 |
| Kim, JC | 1 |
| Hwang, SN | 1 |
| Kim, SY | 3 |
| Liu, J | 10 |
| Luo, Y | 3 |
| He, S | 1 |
| Xia, Y | 3 |
| Yao, D | 3 |
| Guo, D | 2 |
| Ying, C | 1 |
| Ying, L | 1 |
| Yanxia, L | 1 |
| Le, W | 1 |
| Lili, C | 1 |
| Yuan, P | 1 |
| Han, W | 4 |
| Xie, L | 4 |
| Cheng, L | 7 |
| Chen, J | 5 |
| Jiang, L | 7 |
| Cozart, MA | 2 |
| Phelan, KD | 3 |
| Wu, H | 3 |
| Mu, S | 1 |
| Birnbaumer, L | 2 |
| Rusch, NJ | 1 |
| Zheng, F | 3 |
| Freitas, ML | 2 |
| Souto, NS | 1 |
| Zorzi, VN | 2 |
| Moreira, MP | 1 |
| Costa, KG | 1 |
| Royes, LF | 4 |
| Zhou, H | 2 |
| Qu, H | 1 |
| Liao, C | 2 |
| Jiang, H | 2 |
| Huang, S | 1 |
| Ghobadi, SN | 2 |
| Telichko, A | 1 |
| Li, N | 2 |
| Habte, FG | 2 |
| Doyle, T | 1 |
| Woznak, JP | 1 |
| Bertram, EH | 2 |
| Lee, KS | 2 |
| Wintermark, M | 2 |
| Sasaki-Takahashi, N | 1 |
| Shinohara, H | 2 |
| Shioda, S | 1 |
| Seki, T | 2 |
| Geng, J | 1 |
| Guo, H | 1 |
| Zhao, H | 2 |
| Ai, Y | 1 |
| Wyeth, M | 1 |
| Nagendran, M | 1 |
| Buckmaster, PS | 22 |
| Paudel, YN | 1 |
| Kumari, Y | 1 |
| Abidin, SAZ | 1 |
| Othman, I | 1 |
| Shaikh, MF | 2 |
| Yu, YH | 1 |
| Yoo, DY | 1 |
| Kim, DS | 7 |
| Tan, X | 2 |
| Zeng, Y | 1 |
| Tu, Z | 2 |
| Li, P | 2 |
| Tu, S | 2 |
| Xing, J | 1 |
| Xu, D | 2 |
| Li, X | 9 |
| Sun, L | 1 |
| Lian, Y | 2 |
| Xie, N | 3 |
| Cheng, X | 1 |
| Chen, C | 2 |
| Xu, H | 1 |
| Zheng, Y | 2 |
| Yang, P | 3 |
| Qin, Y | 1 |
| Zhu, Y | 4 |
| Li, F | 2 |
| Xia, SS | 1 |
| Zhou, B | 1 |
| Lu, J | 2 |
| Huang, HY | 1 |
| Fernández-García, S | 1 |
| Sancho-Balsells, A | 1 |
| Longueville, S | 1 |
| Hervé, D | 1 |
| Gruart, A | 1 |
| Delgado-García, JM | 1 |
| Alberch, J | 2 |
| Giralt, A | 2 |
| Zhu, J | 3 |
| Park, S | 1 |
| Jeong, KH | 3 |
| Kim, WJ | 2 |
| Park, KM | 1 |
| Kim, JE | 19 |
| Choi, IY | 1 |
| Cho, KO | 7 |
| Chen, M | 2 |
| Zhao, QY | 1 |
| Edson, J | 1 |
| Zhang, ZH | 1 |
| Wei, W | 1 |
| Bredy, T | 1 |
| Reutens, DC | 2 |
| Vyas, P | 1 |
| Tulsawani, RK | 1 |
| Vohora, D | 2 |
| Ohgomori, T | 1 |
| Jinno, S | 1 |
| Singh, N | 1 |
| Serres, F | 1 |
| Toker, L | 1 |
| Sade, Y | 1 |
| Blackburn, V | 1 |
| Batra, AS | 1 |
| Saiardi, A | 1 |
| Agam, G | 1 |
| Belmaker, RH | 3 |
| Sharp, T | 1 |
| Vasudevan, SR | 1 |
| Churchill, GC | 1 |
| Yang, N | 1 |
| Wang, JT | 1 |
| Song, Y | 3 |
| Liang, JM | 1 |
| Ma, DH | 1 |
| Zhang, YF | 3 |
| Hu, H | 2 |
| Zhu, T | 1 |
| Gong, L | 1 |
| Zhao, Y | 1 |
| Shao, Y | 2 |
| Li, S | 5 |
| Sun, Z | 2 |
| Ling, Y | 1 |
| Tao, Y | 1 |
| Ying, Y | 1 |
| Lan, C | 1 |
| Xie, Y | 5 |
| Jiang, P | 1 |
| Brennan, GP | 1 |
| Bauer, S | 1 |
| Engel, T | 2 |
| Jimenez-Mateos, EM | 2 |
| Del Gallo, F | 1 |
| Hill, TDM | 1 |
| Connolly, NMC | 1 |
| Costard, LS | 1 |
| Neubert, V | 1 |
| Salvetti, B | 1 |
| Sanz-Rodriguez, A | 1 |
| Heiland, M | 1 |
| Mamad, O | 1 |
| Brindley, E | 1 |
| Norwood, B | 1 |
| Batool, A | 1 |
| Raoof, R | 1 |
| El-Naggar, H | 1 |
| Reschke, CR | 2 |
| Delanty, N | 1 |
| Prehn, JHM | 1 |
| Fabene, P | 1 |
| Mooney, C | 1 |
| Rosenow, F | 1 |
| Henshall, DC | 2 |
| Jeong, JH | 2 |
| Lee, SH | 5 |
| Kho, AR | 3 |
| Hong, DK | 2 |
| Kang, DH | 1 |
| Kang, BS | 1 |
| Park, MK | 1 |
| Choi, BY | 5 |
| Choi, HC | 8 |
| Lim, MS | 1 |
| Suh, SW | 6 |
| Janicot, R | 1 |
| Stafstrom, CE | 2 |
| Shao, LR | 1 |
| Rashidi, N | 1 |
| Pant, AD | 1 |
| Salinas, SD | 1 |
| Shah, M | 1 |
| Thomas, VS | 1 |
| Dorairaj, S | 1 |
| Amini, R | 1 |
| Sanabria, V | 1 |
| Bittencourt, S | 2 |
| Perosa, SR | 6 |
| de la Rosa, T | 1 |
| da Graça Naffah-Mazzacoratti, M | 7 |
| Andersen, ML | 6 |
| Tufik, S | 8 |
| Amado, D | 13 |
| Shakeel, W | 1 |
| Javaid, S | 1 |
| Anjum, SMM | 1 |
| Rasool, MF | 1 |
| Samad, N | 1 |
| Alasmari, F | 1 |
| Alasmari, AF | 1 |
| Alaqil, FA | 1 |
| Alqarni, SA | 1 |
| Alotaibi, FM | 1 |
| Alqahtani, F | 1 |
| Imran, I | 2 |
| Sharma, S | 2 |
| Sharma, M | 1 |
| Rana, AK | 2 |
| Joshi, R | 1 |
| Swarnkar, MK | 1 |
| Acharya, V | 1 |
| Singh, D | 2 |
| Sakai, K | 1 |
| Yamanaka, G | 1 |
| Yasunaga, M | 1 |
| Hashiguchi, K | 1 |
| Tominaga, K | 1 |
| Kataoka, Y | 1 |
| Yamauchi, A | 1 |
| Yang, CS | 2 |
| Chiu, SC | 1 |
| Liu, PY | 1 |
| Wu, SN | 5 |
| Lai, MC | 6 |
| Huang, CW | 5 |
| Ivanova, N | 1 |
| Pawlik, MJ | 1 |
| Obara-Michlewska, M | 1 |
| Popek, MP | 1 |
| Czarnecka, AM | 1 |
| Czuczwar, SJ | 1 |
| Łuszczki, J | 1 |
| Kołodziej, M | 1 |
| Acewicz, A | 1 |
| Wierzba-Bobrowicz, T | 1 |
| Albrecht, J | 1 |
| Xia, S | 1 |
| Yu, Q | 1 |
| Kuang, W | 1 |
| Huang, H | 6 |
| Schmidt, S | 1 |
| Pothmann, L | 3 |
| Müller-Komorowska, D | 1 |
| Soares da Silva, P | 1 |
| Beck, H | 13 |
| Núñez-Ochoa, MA | 1 |
| Chiprés-Tinajero, GA | 1 |
| Medina-Ceja, L | 2 |
| Lamie, PF | 1 |
| El-Kalaawy, AM | 1 |
| Abdel Latif, NS | 1 |
| Rashed, LA | 1 |
| Philoppes, JN | 1 |
| Lu, D | 1 |
| Ji, Y | 1 |
| Sundaram, P | 1 |
| Traub, RD | 1 |
| Guan, Y | 2 |
| Zhou, J | 5 |
| Li, T | 4 |
| Zhe Sun, P | 1 |
| Luan, G | 2 |
| Okada, Y | 1 |
| Nisar, U | 1 |
| Shahid, M | 1 |
| Askani, M | 1 |
| Malhi, SM | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Lybrand, ZR | 2 |
| Goswami, S | 1 |
| Jarzabek, V | 1 |
| Merlock, N | 1 |
| Aktar, M | 2 |
| Smith, C | 1 |
| Varma, P | 2 |
| Ge, S | 1 |
| Hsieh, J | 4 |
| Yang, Y | 6 |
| Li, Y | 14 |
| Han, J | 1 |
| Benassi, SK | 2 |
| Alves, JGSM | 1 |
| Guidoreni, CG | 1 |
| Massant, CG | 1 |
| Garrido-Sanabria, E | 1 |
| Loduca, RDS | 1 |
| Susemihl, MA | 1 |
| Paiva, WS | 1 |
| de Andrade, AF | 1 |
| Teixeira, MJ | 1 |
| Andrade, JQ | 1 |
| Garzon, E | 1 |
| Charret, TS | 1 |
| Pereira, MTM | 1 |
| Cristina Rheder Fagundes Pascoal, A | 1 |
| Sano, F | 1 |
| Shigetomi, E | 1 |
| Shinozaki, Y | 1 |
| Tsuzukiyama, H | 1 |
| Saito, K | 2 |
| Mikoshiba, K | 1 |
| Horiuchi, H | 1 |
| Cheung, DL | 1 |
| Nabekura, J | 1 |
| Sugita, K | 1 |
| Aihara, M | 1 |
| Koizumi, S | 1 |
| Sadeghi, L | 1 |
| Rizvanov, AA | 1 |
| Dabirmanesh, B | 1 |
| Salafutdinov, II | 1 |
| Sayyah, M | 2 |
| Shojaei, A | 1 |
| Zahiri, J | 1 |
| Mirnajafi-Zadeh, J | 2 |
| Khorsand, B | 1 |
| Khajeh, K | 1 |
| Fathollahi, Y | 1 |
| Yoanidu, L | 1 |
| Marinov, P | 1 |
| Qiu, L | 1 |
| Keunen, O | 1 |
| Huang, A | 1 |
| Hou, Q | 1 |
| Narang, S | 1 |
| Abd El-Hameed, AM | 1 |
| Abuelsaad, ASA | 1 |
| Khalil, A | 1 |
| Al-Rafiah, AR | 1 |
| Mehdar, KM | 1 |
| Shiono, S | 1 |
| Batabyal, T | 1 |
| Labuz, A | 1 |
| Williamson, J | 2 |
| Kapur, J | 3 |
| Joshi, S | 4 |
| McDonald, TS | 4 |
| Biagini, G | 16 |
| de Curtis, M | 6 |
| Gnatkovsky, V | 3 |
| Xiao, Z | 4 |
| Peng, J | 6 |
| Wu, L | 3 |
| Arafat, A | 2 |
| Yin, F | 6 |
| Gan, N | 3 |
| Lin, Z | 3 |
| Gu, Y | 1 |
| Huang, K | 1 |
| Hu, Y | 3 |
| Ji, Z | 1 |
| Yang, T | 3 |
| Pan, S | 2 |
| Herrington, R | 1 |
| Leclerc, L | 1 |
| Rogawski, MA | 3 |
| Brulet, R | 3 |
| Karyakin, VB | 2 |
| Vasil'ev, DS | 1 |
| Zhuravin, IA | 1 |
| Magazanik, LG | 4 |
| Zhu, K | 4 |
| Yuan, B | 3 |
| Hu, M | 5 |
| Feng, GF | 2 |
| Liu, JX | 8 |
| Ivanov, AD | 1 |
| Watanabe, S | 2 |
| Saito, M | 2 |
| Soma, M | 1 |
| Miyaoka, H | 2 |
| Takahashi, M | 2 |
| Andres-Mach, M | 1 |
| Zagaja, M | 1 |
| Haratym-Maj, A | 1 |
| Rola, R | 1 |
| Maj, M | 1 |
| Haratym, J | 1 |
| Dudra-Jastrzębska, M | 1 |
| Łuszczki, JJ | 1 |
| Ma, L | 4 |
| Li, R | 3 |
| Ou, S | 3 |
| Vizuete, AFK | 2 |
| Hennemann, MM | 1 |
| Gonçalves, CA | 2 |
| de Oliveira, DL | 2 |
| Mante, PK | 1 |
| Adongo, DW | 1 |
| Woode, E | 1 |
| Shavit Stein, E | 1 |
| Segal, M | 1 |
| Rajasekaran, K | 3 |
| Niquet, J | 8 |
| Baldwin, R | 4 |
| Norman, K | 2 |
| Suchomelova, L | 9 |
| Lumley, L | 3 |
| Wasterlain, CG | 11 |
| Du, X | 1 |
| Parent, JM | 5 |
| Luo, Q | 1 |
| Ren, Z | 1 |
| Zhu, L | 1 |
| Feng, Y | 1 |
| Ko, AR | 4 |
| Kang, TC | 15 |
| Xu, M | 1 |
| Sun, P | 1 |
| Yang, CH | 1 |
| Wei, X | 1 |
| Ma, XX | 1 |
| Yang, CR | 1 |
| Ni, KM | 1 |
| Zhang, YJ | 2 |
| Li, XM | 2 |
| Shiha, AA | 3 |
| Bankstahl, JP | 6 |
| Lin, W | 1 |
| Huang, W | 1 |
| Chen, S | 11 |
| Lin, M | 1 |
| Huang, Q | 2 |
| Müller, JA | 3 |
| Keck, M | 1 |
| Androsova, G | 1 |
| Gualtieri, F | 3 |
| Walker, A | 2 |
| von Rüden, EL | 1 |
| Russmann, V | 1 |
| Deeg, CA | 1 |
| Hauck, SM | 1 |
| Krause, R | 1 |
| de Melo, CGF | 1 |
| Salgado, PRR | 1 |
| da Fonsêca, DV | 1 |
| Braga, RM | 1 |
| Filho, MRDC | 1 |
| de Farias, IEV | 1 |
| de Luna Freire Pessôa, H | 1 |
| Lima, EM | 1 |
| do Amaral, IPG | 1 |
| de Sousa, DP | 1 |
| de Almeida, RN | 1 |
| Medel-Matus, JS | 4 |
| Shin, D | 10 |
| Sankar, R | 11 |
| Mazarati, A | 6 |
| Uemori, T | 1 |
| Toda, K | 1 |
| Tamir, I | 1 |
| Daninos, M | 1 |
| Yaari, Y | 5 |
| Iqbal, M | 1 |
| Rahman, MS | 1 |
| Zafar, S | 1 |
| Chen, XL | 4 |
| Mahfoz, AM | 1 |
| Abdel-Wahab, AF | 1 |
| Afify, MA | 1 |
| Shahzad, N | 1 |
| Ibrahim, IAA | 1 |
| ElSawy, NA | 1 |
| Bamagous, GA | 1 |
| Al Ghamdi, SS | 1 |
| Wang, T | 1 |
| Behr, C | 3 |
| Stroh, T | 1 |
| Lösing, P | 1 |
| Niturad, CE | 1 |
| Harrer, M | 1 |
| Reckendorf, CMZ | 1 |
| Schatz, T | 1 |
| Sinske, D | 1 |
| Lerche, H | 1 |
| Maljevic, S | 1 |
| Knöll, B | 1 |
| Lee, H | 1 |
| Jung, S | 3 |
| Lee, P | 1 |
| Jeong, Y | 1 |
| Wang, HK | 1 |
| Yan, H | 1 |
| Wang, K | 3 |
| de Lima, C | 1 |
| Arida, RM | 22 |
| Polesel, DN | 1 |
| de Alvarenga, TAF | 1 |
| Vancini, RL | 1 |
| Matos, G | 6 |
| Casalia, ML | 1 |
| Howard, MA | 1 |
| Baraban, SC | 1 |
| Godoy, LD | 1 |
| Liberato, JL | 1 |
| Celani, MVB | 1 |
| Gobbo-Neto, L | 1 |
| Lopes, NP | 1 |
| Dos Santos, WF | 1 |
| Pessoa, DT | 2 |
| da Silva, ELA | 2 |
| Costa, EVL | 2 |
| Nogueira, RA | 2 |
| Danelon, V | 1 |
| Montroull, L | 1 |
| Vallejo, M | 1 |
| Cabrera, J | 1 |
| Agnese, A | 1 |
| Ortega, MG | 1 |
| Mascó, D | 1 |
| Ferreira, ES | 1 |
| Vieira, LG | 1 |
| Moraes, DM | 1 |
| Amorim, BO | 2 |
| Hamani, C | 7 |
| Lin, WH | 1 |
| Li, XF | 1 |
| Lin, MX | 1 |
| Zhou, Y | 1 |
| Huang, HP | 1 |
| Zeng, X | 3 |
| Zhou, L | 7 |
| Luo, W | 2 |
| Hu, K | 4 |
| Ouyang, D | 2 |
| da Costa E Silva, LD | 1 |
| Regner, GG | 2 |
| Boaretto, FBM | 1 |
| Hoffmann, C | 1 |
| da Silva, LL | 2 |
| Steffens, LR | 1 |
| Morás, AM | 1 |
| Moura, DJ | 1 |
| Mehrabi, S | 2 |
| Sanadgol, N | 1 |
| Barati, M | 2 |
| Shahbazi, A | 1 |
| Vahabzadeh, G | 1 |
| Barzroudi, M | 1 |
| Seifi, M | 1 |
| Gholipourmalekabadi, M | 1 |
| Golab, F | 1 |
| Gao, Q | 1 |
| Zong, W | 2 |
| Jiang, D | 1 |
| Zeng, G | 2 |
| Xiao, J | 1 |
| Xiao, B | 10 |
| Ferrazoli, E | 1 |
| Valente, MF | 1 |
| Romariz, S | 2 |
| Janisset, NRLL | 1 |
| Macedo, CE | 1 |
| Antonio, BB | 1 |
| Barros, V | 1 |
| Mundim, M | 1 |
| Porcionatto, M | 1 |
| Aarão, MC | 1 |
| Miranda, MF | 1 |
| Rodrigues, AM | 2 |
| de Almeida, AG | 1 |
| Longo, BM | 4 |
| Lee, SY | 3 |
| Song, HK | 8 |
| Wang, X | 31 |
| Kong, H | 3 |
| You, B | 1 |
| Oliveira, CV | 4 |
| Grigoletto, J | 4 |
| Canzian, JM | 1 |
| Duarte, MMMF | 1 |
| Duarte, T | 1 |
| Hung, TY | 1 |
| Lin, KM | 2 |
| Sung, PS | 1 |
| Wu, SJ | 2 |
| Wu, YJ | 2 |
| Tsai, JJ | 3 |
| Suemaru, K | 1 |
| Yoshikawa, M | 1 |
| Tanaka, A | 1 |
| Araki, H | 1 |
| Aso, H | 1 |
| Watanabe, M | 1 |
| Hosford, BE | 2 |
| Rowley, S | 2 |
| Liska, JP | 2 |
| Martinello, K | 1 |
| Sciaccaluga, M | 1 |
| Morace, R | 1 |
| Mascia, A | 1 |
| Arcella, A | 1 |
| Esposito, V | 1 |
| Fucile, S | 1 |
| Abbasova, K | 1 |
| Xiong, TQ | 2 |
| Chen, LM | 1 |
| Tan, BH | 2 |
| Guo, CY | 1 |
| Li, YN | 2 |
| Li, SL | 2 |
| Li, YC | 2 |
| Gao, F | 4 |
| Gao, Y | 1 |
| Meng, F | 1 |
| Yang, C | 1 |
| Fu, J | 1 |
| Smith, ZZ | 1 |
| Benison, AM | 1 |
| Bercum, FM | 1 |
| Dudek, FE | 8 |
| Barth, DS | 1 |
| Yue, ZW | 2 |
| Wang, YL | 3 |
| Salem, NA | 1 |
| El-Shamarka, M | 1 |
| Khadrawy, Y | 1 |
| El-Shebiney, S | 1 |
| Fukumura, S | 1 |
| Sasaki, M | 1 |
| Kataoka-Sasaki, Y | 1 |
| Oka, S | 1 |
| Nakazaki, M | 1 |
| Nagahama, H | 1 |
| Morita, T | 1 |
| Sakai, T | 1 |
| Tsutsumi, H | 1 |
| Kocsis, JD | 1 |
| Honmou, O | 1 |
| Ding, X | 1 |
| Hansen, F | 1 |
| Negri, E | 1 |
| Leite, MC | 1 |
| Funck, VR | 4 |
| Larrick, JW | 2 |
| Li, CJ | 1 |
| Xu, JH | 2 |
| Vashishta, A | 1 |
| Slomnicki, LP | 1 |
| Pietrzak, M | 1 |
| Smith, SC | 1 |
| Kolikonda, M | 1 |
| Naik, SP | 1 |
| Parlato, R | 1 |
| Hetman, M | 1 |
| Wang, RF | 2 |
| Xue, GF | 2 |
| Hölscher, C | 2 |
| Tian, MJ | 2 |
| Feng, P | 1 |
| Zheng, JY | 1 |
| Li, DF | 2 |
| Kim, TJ | 3 |
| Jun, JS | 2 |
| Park, B | 1 |
| Byun, JI | 2 |
| Sunwoo, JS | 2 |
| Jung, KY | 3 |
| Kim, M | 8 |
| Khadrawy, YA | 1 |
| Sawie, HG | 1 |
| Hosny, EN | 1 |
| Mann, A | 2 |
| Portnoy, E | 2 |
| Han, H | 2 |
| Inbar, D | 1 |
| Blatch, D | 1 |
| Shmuel, M | 2 |
| Ben-Hur, T | 1 |
| Eyal, S | 2 |
| Ekstein, D | 2 |
| Hawk, KM | 2 |
| Chester, SJ | 2 |
| Goodkin, HP | 3 |
| Smirnova, EY | 1 |
| Malkin, SL | 2 |
| Chizhov, AV | 1 |
| Tian, X | 1 |
| Wang, W | 5 |
| Yang, Q | 3 |
| Lin, P | 1 |
| Ma, Y | 1 |
| Xiong, Y | 4 |
| Lu, S | 1 |
| Luo, J | 6 |
| Xiao, F | 2 |
| Pardo-Peña, K | 1 |
| Sánchez-Lira, A | 1 |
| Salazar-Sánchez, JC | 1 |
| Morales-Villagrán, A | 1 |
| Peng, WF | 2 |
| Fan, F | 2 |
| Zhang, QQ | 2 |
| Ding, J | 4 |
| Ni, H | 1 |
| Chen, SH | 1 |
| Li, LL | 1 |
| Jin, MF | 1 |
| Jang, Y | 1 |
| Park, BS | 1 |
| Yu, JS | 1 |
| Yang, AR | 1 |
| Fan, Z | 2 |
| Feng, X | 1 |
| Zhu, X | 5 |
| Yin, S | 1 |
| Nejatbakhsh, M | 1 |
| Saboory, E | 2 |
| Bagheri, M | 1 |
| Yu, S | 2 |
| Zhang, T | 1 |
| Wulsin, AC | 1 |
| Franco-Villanueva, A | 1 |
| Romancheck, C | 1 |
| Morano, RL | 1 |
| Smith, BL | 1 |
| Packard, BA | 1 |
| Herman, JP | 1 |
| Pottoo, FH | 1 |
| Tabassum, N | 1 |
| Javed, MN | 1 |
| Nigar, S | 1 |
| Rasheed, R | 1 |
| Khan, A | 1 |
| Barkat, MA | 1 |
| Alam, MS | 1 |
| Maqbool, A | 1 |
| Ansari, MA | 1 |
| Barreto, GE | 1 |
| Ashraf, GM | 1 |
| Song, S | 1 |
| Fajol, A | 1 |
| Ren, B | 1 |
| Shi, S | 1 |
| Durie, D | 1 |
| Brendel, M | 1 |
| Waldron, AM | 1 |
| Gildehaus, FJ | 1 |
| von Ungern-Sternberg, B | 1 |
| Lindner, M | 1 |
| Ziegler, S | 1 |
| Gass, P | 1 |
| Bartenstein, P | 2 |
| Kuehn, JC | 1 |
| van Loo, KMJ | 2 |
| Elger, CE | 7 |
| Nirwan, N | 1 |
| Siraj, F | 1 |
| Holtkamp, D | 2 |
| Hebeisen, S | 1 |
| Soares-da-Silva, P | 1 |
| Mohammad, H | 1 |
| Sekar, S | 1 |
| Wei, Z | 1 |
| Moien-Afshari, F | 1 |
| Taghibiglou, C | 1 |
| Vinet, J | 3 |
| Costa, AM | 1 |
| Salinas-Navarro, M | 1 |
| Leo, G | 2 |
| Moons, L | 1 |
| Arckens, L | 1 |
| Abdanipour, A | 3 |
| Deheshjo, F | 1 |
| Sohrabi, D | 1 |
| Jafari Anarkooli, I | 1 |
| Nejatbakhsh, R | 2 |
| Jiang, Y | 5 |
| Han, CL | 1 |
| Liu, HG | 1 |
| Zhang, X | 5 |
| Meng, FG | 1 |
| Zhang, JG | 1 |
| Zhu, M | 1 |
| Xu, K | 4 |
| Han, B | 1 |
| Huang, R | 1 |
| Zhang, A | 2 |
| Yao, H | 1 |
| Han, K | 1 |
| Wang, QY | 1 |
| Wang, CX | 1 |
| Luan, SY | 1 |
| Tian, WP | 1 |
| Zhang, RY | 1 |
| Liu, JT | 1 |
| Wu, SX | 1 |
| Kuang, F | 1 |
| Wu, XQ | 1 |
| Zhao, YN | 1 |
| Si, Z | 1 |
| Cheng, DF | 1 |
| Shi, HC | 1 |
| Greene, DL | 1 |
| Kosenko, A | 1 |
| Hoshi, N | 1 |
| Dutra, MRH | 1 |
| Feliciano, RDS | 1 |
| Jacinto, KR | 1 |
| Gouveia, TLF | 1 |
| Brigidio, E | 1 |
| Serra, AJ | 1 |
| Morris, M | 1 |
| Naffah-Mazzacoratti, MDG | 2 |
| Silva, JA | 4 |
| Luiz Gomes, A | 1 |
| Dimitrova Tchekalarova, J | 1 |
| da Conceição Machado, K | 1 |
| de Sousa Rios, MA | 1 |
| Paz, MFCJ | 1 |
| Găman, MA | 1 |
| Găman, AM | 1 |
| Yele, S | 1 |
| Shill, MC | 1 |
| Khan, IN | 1 |
| Islam, MA | 1 |
| Ali, ES | 1 |
| Mishra, SK | 1 |
| Islam, MT | 1 |
| Mubarak, MS | 1 |
| da Silva Lopes, L | 1 |
| de Carvalho Melo-Cavalcante, AA | 1 |
| Srivastava, PK | 1 |
| van Eyll, J | 2 |
| Godard, P | 1 |
| Mazzuferi, M | 3 |
| Delahaye-Duriez, A | 1 |
| Van Steenwinckel, J | 1 |
| Gressens, P | 1 |
| Danis, B | 2 |
| Vandenplas, C | 1 |
| Foerch, P | 2 |
| Leclercq, K | 2 |
| Mairet-Coello, G | 1 |
| Cardenas, A | 1 |
| Vanclef, F | 1 |
| Laaniste, L | 1 |
| Niespodziany, I | 2 |
| Keaney, J | 1 |
| Gasser, J | 1 |
| Gillet, G | 1 |
| Shkura, K | 1 |
| Chong, SA | 1 |
| Behmoaras, J | 1 |
| Kadiu, I | 1 |
| Petretto, E | 1 |
| Kaminski, RM | 5 |
| Johnson, MR | 1 |
| Kalemenev, SV | 2 |
| Schwarz, AP | 1 |
| Santana-Gómez, CE | 5 |
| Valle-Dorado, MG | 2 |
| Domínguez-Valentín, AE | 1 |
| Hernández-Moreno, A | 1 |
| Orozco-Suárez, S | 2 |
| Rocha, L | 8 |
| Bajorat, R | 2 |
| Porath, K | 2 |
| Kuhn, J | 1 |
| Goßla, E | 1 |
| Goerss, D | 1 |
| Sellmann, T | 2 |
| Köhling, R | 6 |
| Kirschstein, T | 8 |
| Hu, XB | 1 |
| Gao, LY | 1 |
| Wu, XR | 1 |
| Chu, X | 1 |
| Zhou, SH | 1 |
| Kong, QX | 1 |
| Yeh, PS | 1 |
| Luna-Munguia, H | 3 |
| Zestos, AG | 1 |
| Gliske, SV | 1 |
| Kennedy, RT | 1 |
| Stacey, WC | 1 |
| Wu, Q | 2 |
| Wang, H | 4 |
| Contreras-García, IJ | 1 |
| Sánchez-Huerta, K | 1 |
| Ramírez-Hernández, R | 1 |
| Gómez-González, B | 1 |
| Mendoza Torreblanca, JG | 1 |
| Pansani, AP | 3 |
| Cysneiros, RM | 11 |
| Colugnati, DB | 7 |
| Janjoppi, L | 1 |
| Ferrari, D | 3 |
| de Lima, E | 4 |
| Ghazale, PP | 2 |
| Sinigaglia-Coimbra, R | 2 |
| Scorza, FA | 31 |
| Chwiej, JG | 1 |
| Ciesielka, SW | 1 |
| Skoczen, AK | 1 |
| Janeczko, KJ | 1 |
| Sandt, C | 2 |
| Planeta, KL | 1 |
| Setkowicz, ZK | 1 |
| Semenikhina, M | 1 |
| Bogovyk, R | 1 |
| Fedoriuk, M | 1 |
| Nikolaienko, O | 1 |
| Al Kury, LT | 1 |
| Savotchenko, A | 1 |
| Krishtal, O | 1 |
| Isaeva, E | 2 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Li, YJ | 1 |
| Zhang, B | 2 |
| Yang, CM | 1 |
| Vitorino, PR | 1 |
| Gomes, KP | 1 |
| da Silva, M | 1 |
| Mendes, EP | 1 |
| Dos Santos, FCA | 1 |
| de Castro, CH | 1 |
| Derera, ID | 1 |
| Smith, KC | 1 |
| Smith, BN | 4 |
| Patra, PH | 1 |
| Barker-Haliski, M | 1 |
| White, HS | 1 |
| Whalley, BJ | 3 |
| Glyn, S | 1 |
| Sandhu, H | 1 |
| Jones, N | 1 |
| Bazelot, M | 1 |
| Williams, CM | 3 |
| McNeish, AJ | 1 |
| Gao, J | 1 |
| An, L | 1 |
| Xu, Y | 6 |
| Huang, Y | 6 |
| Bulduk, EB | 1 |
| Kurt, G | 1 |
| Barun, S | 1 |
| Aydemir, O | 1 |
| Kiziltas, M | 1 |
| Oktem, M | 1 |
| Turhan, T | 1 |
| Atilla, P | 1 |
| Muftuoglu, S | 1 |
| Vinogradova, LV | 2 |
| Li, C | 3 |
| Huang, X | 3 |
| Ouyang, DS | 2 |
| Nile, C | 1 |
| Falleni, M | 1 |
| Cirasola, D | 1 |
| Alghamdi, A | 1 |
| Anderson, OF | 1 |
| Delaney, C | 1 |
| Ramage, G | 1 |
| Ottaviano, E | 1 |
| Tosi, D | 1 |
| Bulfamante, G | 1 |
| Morace, G | 1 |
| Borghi, E | 1 |
| Dong, J | 2 |
| Liu, L | 2 |
| Zhu, F | 2 |
| Zeng, L | 3 |
| Meller, S | 1 |
| Brandt, C | 10 |
| Theilmann, W | 1 |
| Klein, J | 2 |
| Löscher, W | 23 |
| van Luijtelaar, G | 1 |
| Sun, M | 1 |
| Zhu, HX | 1 |
| Fu, WL | 1 |
| Xu, XW | 1 |
| Yang, JZ | 1 |
| Dai, D | 1 |
| Jang, HJ | 1 |
| Lim, SC | 1 |
| Liu, F | 1 |
| Xu, W | 1 |
| Wu, G | 1 |
| Rummel, CK | 1 |
| Bikbaev, AF | 1 |
| Martinez-Chavez, E | 1 |
| Blaess, S | 1 |
| Dietrich, D | 2 |
| Heine, M | 1 |
| Qu, Z | 1 |
| Jia, L | 1 |
| Xie, T | 1 |
| Zhen, J | 1 |
| Si, P | 1 |
| Cui, Z | 1 |
| Xue, Y | 2 |
| Sun, C | 1 |
| Hu, X | 3 |
| Tang, J | 1 |
| Lan, X | 1 |
| Mi, X | 3 |
| Song, X | 3 |
| Liu, W | 2 |
| Yao, Y | 1 |
| Liu, N | 1 |
| Zheng, P | 1 |
| Guo, F | 1 |
| Sun, T | 1 |
| Zhou, R | 1 |
| Colciaghi, F | 2 |
| Nobili, P | 2 |
| Cipelletti, B | 2 |
| Cagnoli, C | 1 |
| Zambon, S | 1 |
| Locatelli, D | 2 |
| Battaglia, GS | 1 |
| Xiao, Q | 2 |
| Tang, H | 1 |
| Kong, L | 1 |
| Ji, H | 1 |
| Cui, G | 1 |
| Mousavi-Hasanzadeh, M | 1 |
| Rezaeian-Varmaziar, H | 1 |
| Shafaat, O | 1 |
| Jand, A | 1 |
| Palizvan, MR | 1 |
| Jia, R | 1 |
| Jia, N | 1 |
| Yang, F | 3 |
| Liu, Z | 3 |
| Zhao, J | 2 |
| Zhang, Z | 2 |
| Wu, S | 2 |
| Jiang, W | 5 |
| Mi, RL | 1 |
| Yuan, ZY | 1 |
| Moradi, P | 1 |
| Ganjkhani, M | 3 |
| Anarkooli, IJ | 1 |
| Benifla, M | 1 |
| Polyak, B | 1 |
| Nourozi, S | 1 |
| Bigonah, R | 1 |
| Rostami, A | 1 |
| Shokri, S | 2 |
| Alese, OO | 1 |
| Mabandla, MV | 1 |
| Shen, Y | 1 |
| Peng, W | 1 |
| Chen, Q | 2 |
| Hammock, BD | 1 |
| Li, D | 2 |
| Yang, J | 5 |
| Needs, HI | 1 |
| Henley, BS | 1 |
| Cavallo, D | 1 |
| Gurung, S | 1 |
| Modebadze, T | 1 |
| Woodhall, G | 1 |
| Henley, JM | 1 |
| Mazumder, AG | 1 |
| Patial, V | 1 |
| Chen, LL | 1 |
| Feng, HF | 1 |
| Mao, XX | 1 |
| Ye, Q | 1 |
| Zeng, LH | 1 |
| Kharatishvili, I | 1 |
| Shan, ZY | 1 |
| She, DT | 1 |
| Foong, S | 1 |
| Kurniawan, ND | 1 |
| Lee, DS | 1 |
| Ryu, HJ | 6 |
| Kim, YI | 3 |
| Du, Y | 2 |
| Zou, Y | 2 |
| Yu, W | 3 |
| Shi, R | 2 |
| Yang, W | 2 |
| Duan, J | 1 |
| Deng, Y | 2 |
| Lü, Y | 2 |
| Brewster, AL | 1 |
| Lugo, JN | 2 |
| Patil, VV | 1 |
| Lee, WL | 4 |
| Qian, Y | 1 |
| Vanegas, F | 1 |
| Anderson, AE | 2 |
| Hirotsu, C | 2 |
| Kagawa, Y | 1 |
| Itoh, S | 1 |
| Shin, R | 1 |
| Kobayashi, K | 1 |
| Hagihara, H | 1 |
| Kogan, JH | 1 |
| Miyake, S | 1 |
| Tajinda, K | 1 |
| Walton, NM | 1 |
| Gross, AK | 1 |
| Heusner, CL | 1 |
| Tamura, K | 1 |
| Miyakawa, T | 1 |
| Matsumoto, M | 1 |
| Lopes, MD | 1 |
| Lopes, AC | 1 |
| Scorza, CA | 8 |
| Collins-Praino, LE | 2 |
| Paul, NE | 1 |
| Ledgard, F | 1 |
| Podurgiel, SJ | 2 |
| Kovner, R | 1 |
| Baqi, Y | 2 |
| Müller, CE | 3 |
| Senatus, PB | 1 |
| Salamone, JD | 6 |
| Soman, S | 2 |
| Anju, TR | 1 |
| Jayanarayanan, S | 1 |
| Antony, S | 2 |
| Paulose, CS | 6 |
| Smeland, OB | 2 |
| Hadera, MG | 2 |
| Sonnewald, U | 2 |
| Yin, P | 1 |
| Li, Z | 5 |
| Wang, YY | 1 |
| Qiao, NN | 1 |
| Huang, SY | 1 |
| Li, BM | 1 |
| Sun, RP | 2 |
| Faure, JB | 2 |
| Akimana, G | 2 |
| Carneiro, JE | 1 |
| Cosquer, B | 2 |
| Ferrandon, A | 8 |
| Geiger, K | 1 |
| Koning, E | 9 |
| Penazzi, L | 1 |
| Cassel, JC | 2 |
| Nehlig, A | 20 |
| Kumar, G | 2 |
| Sonoda, EY | 3 |
| Hester, MS | 2 |
| Ye, Y | 1 |
| Xiong, J | 1 |
| Hu, J | 2 |
| Kong, M | 1 |
| Cheng, JT | 1 |
| Huang, CC | 1 |
| Suidan, GL | 1 |
| Brill, A | 1 |
| De Meyer, SF | 1 |
| Voorhees, JR | 1 |
| Cifuni, SM | 1 |
| Cabral, JE | 1 |
| Wagner, DD | 1 |
| Richard, GR | 2 |
| Titiz, A | 1 |
| Tyler, A | 1 |
| Holmes, GL | 11 |
| Scott, RC | 6 |
| Lenck-Santini, PP | 3 |
| Heng, K | 1 |
| Haney, MM | 2 |
| Tan, KN | 3 |
| Kutorasinska, J | 2 |
| Setkowicz, Z | 3 |
| Janeczko, K | 3 |
| Dumas, P | 1 |
| Chwiej, J | 3 |
| Besio, W | 2 |
| Cuellar-Herrera, M | 2 |
| Zhu, S | 1 |
| Tai, C | 1 |
| Petkau, TL | 1 |
| Dong, Z | 1 |
| Wen, W | 1 |
| Chang, Q | 1 |
| Tian Wang, Y | 1 |
| MacVicar, BA | 1 |
| Leavitt, BR | 1 |
| Jia, W | 1 |
| Cynader, MS | 1 |
| Scholl, EA | 1 |
| Ekstrand, JJ | 3 |
| Hill, TD | 2 |
| Cascio, MG | 1 |
| Romano, B | 1 |
| Duncan, M | 2 |
| Pertwee, RG | 1 |
| Hill, AJ | 2 |
| Hoeller, AA | 2 |
| Duarte, FS | 2 |
| Leme, LR | 1 |
| Costa, AP | 3 |
| Santos, EC | 1 |
| de Pieri, CH | 1 |
| dos Santos, AA | 1 |
| Naime, AA | 1 |
| Farina, M | 2 |
| de Lima, TC | 2 |
| Klatte, K | 1 |
| Otte, D | 1 |
| Müller, L | 2 |
| Tokay, T | 1 |
| Kober, M | 1 |
| Uebachs, M | 3 |
| Zimmer, A | 2 |
| Epps, SA | 1 |
| Kahn, AB | 1 |
| Holmes, PV | 1 |
| Boss-Williams, KA | 1 |
| Weiss, JM | 1 |
| Weinshenker, D | 1 |
| Noe, FM | 1 |
| Polascheck, N | 1 |
| Frigerio, F | 1 |
| Bankstahl, M | 9 |
| Ravizza, T | 2 |
| Marchini, S | 1 |
| Beltrame, L | 1 |
| Banderó, CR | 1 |
| Vezzani, A | 4 |
| Marques, TE | 3 |
| de Mendonça, LR | 1 |
| Pereira, MG | 2 |
| de Andrade, TG | 2 |
| Paçó-Larson, ML | 3 |
| Gitaí, DL | 2 |
| Grabenstatter, HL | 5 |
| Del Angel, YC | 1 |
| Carlsen, J | 5 |
| Wempe, MF | 1 |
| White, AM | 4 |
| Cogswell, M | 2 |
| Russek, SJ | 3 |
| Brooks-Kayal, AR | 5 |
| Cai, X | 1 |
| Fang, Z | 2 |
| Liang, F | 1 |
| Wang, B | 1 |
| Le, Y | 1 |
| López-Meraz, ML | 4 |
| Morgado-Valle, C | 1 |
| Beltrán-Parrazal, L | 2 |
| Pérez-Estudillo, C | 1 |
| Manzo, J | 1 |
| Pineda, E | 4 |
| Jentsch, JD | 1 |
| Griesbach, G | 1 |
| Tan, PP | 1 |
| Yuan, HH | 1 |
| Cui, YY | 1 |
| Li, H | 1 |
| Feng, XM | 1 |
| Qiu, Y | 1 |
| Chen, HZ | 1 |
| Zhou, W | 1 |
| Duffy, BA | 1 |
| Chun, KP | 1 |
| Ma, D | 1 |
| Lythgoe, MF | 3 |
| Nakamura-Kiyama, M | 1 |
| Ono, K | 1 |
| Masuda, W | 1 |
| Hitomi, S | 1 |
| Matsuo, K | 1 |
| Usui, M | 1 |
| Nakashima, K | 1 |
| Yokota, M | 1 |
| Inenaga, K | 1 |
| Weng, L | 1 |
| Shi, Q | 2 |
| Chen, T | 2 |
| Hu, L | 1 |
| Hua, N | 1 |
| Guo, Y | 1 |
| Kuang, Y | 1 |
| Ding, Y | 1 |
| Ding, M | 1 |
| Choi, J | 2 |
| Khalid, A | 1 |
| Kim, JM | 2 |
| Shin, JW | 1 |
| Ban, JJ | 2 |
| Yi, GS | 1 |
| Wu, PF | 1 |
| Xiao, W | 1 |
| He, JG | 1 |
| Guan, XL | 1 |
| Zhang, JT | 1 |
| Hu, ZL | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Yang, PB | 1 |
| Zhang, JS | 3 |
| Mazzotti, DR | 1 |
| Guindalini, C | 1 |
| Pearce, PS | 1 |
| Friedman, D | 3 |
| Iyengar, SS | 1 |
| Fenton, AA | 2 |
| Maclusky, NJ | 4 |
| Yang, LB | 1 |
| Zhao, N | 2 |
| Farsiu, S | 1 |
| Chiu, SJ | 1 |
| Gonzalez, P | 1 |
| Lütjen-Drecoll, E | 2 |
| Overby, DR | 2 |
| Stamer, WD | 2 |
| Brehme, H | 2 |
| Schulz, R | 2 |
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Collon, KW | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Marques-Carneiro, JE | 1 |
| Herbeaux, K | 1 |
| Barbelivien, A | 1 |
| Shu, Y | 1 |
| Luo, ZH | 1 |
| Wu, ZG | 1 |
| Kazemi, M | 1 |
| Firouzjaei, MA | 1 |
| Hemadi, M | 1 |
| Moayeri, A | 1 |
| Simões, PSR | 1 |
| Visniauskas, B | 1 |
| Yacubian, EMT | 1 |
| Centeno, R | 1 |
| Canzian, M | 1 |
| Maurer Morelli, CV | 1 |
| Carrete, H | 1 |
| Chagas, JR | 1 |
| Naffah Mazzacoratti, MDG | 1 |
| Raiesdana, S | 1 |
| Esmaeilzadeha, S | 1 |
| Soukupová, M | 2 |
| Binaschi, A | 2 |
| Falcicchia, C | 2 |
| Zucchini, S | 3 |
| Roncon, P | 2 |
| Palma, E | 2 |
| Magri, E | 1 |
| Grandi, E | 1 |
| Simonato, M | 3 |
| Titiz, AS | 1 |
| Mahoney, JM | 2 |
| Testorf, ME | 1 |
| Raol, YH | 2 |
| Hund, D | 1 |
| Cruz Del Angel, Y | 3 |
| Gonzalez, MI | 4 |
| Longo, FM | 1 |
| Bertrand, J | 1 |
| Schicht, M | 1 |
| Paulsen, F | 1 |
| Pearson, JN | 3 |
| Schulz, KM | 1 |
| Patel, M | 4 |
| Gouveia, TL | 1 |
| Iha, HA | 1 |
| Frangiotti, MI | 1 |
| Feliciano, RS | 1 |
| de Almeida, AC | 4 |
| Naffah-Mazzacoratti, MG | 5 |
| Merino-Serrais, P | 1 |
| Fernaud-Espinosa, I | 1 |
| Rodriguez-Alvarez, N | 1 |
| Reynolds, J | 1 |
| Conroy, RM | 1 |
| McKiernan, RC | 1 |
| deFelipe, J | 1 |
| Papageorgiou, IE | 1 |
| Fetani, AF | 1 |
| Lewen, A | 1 |
| Heinemann, U | 6 |
| Kann, O | 1 |
| Kulbida, R | 1 |
| Mandelkow, EM | 1 |
| van Loo, KM | 1 |
| Soussi, R | 1 |
| Boulland, JL | 1 |
| Bassot, E | 1 |
| Bras, H | 1 |
| Coulon, P | 1 |
| Chaudhry, FA | 1 |
| Storm-Mathisen, J | 1 |
| Ferhat, L | 2 |
| Esclapez, M | 7 |
| Li, J | 7 |
| Jiang, G | 5 |
| Wang, Z | 2 |
| de Oliveira, JC | 1 |
| Medeiros, Dde C | 2 |
| de Souza E Rezende, GH | 1 |
| Moraes, MF | 5 |
| Cota, VR | 1 |
| de Araújo, MA | 1 |
| Taniele-Silva, J | 1 |
| Souza, FM | 1 |
| Wijayatunge, R | 1 |
| Chen, LF | 1 |
| Cha, YM | 1 |
| Zannas, AS | 1 |
| Frank, CL | 1 |
| West, AE | 1 |
| Samarasinghe, RA | 1 |
| Kanuparthi, PS | 1 |
| Timothy Greenamyre, J | 1 |
| DeFranco, DB | 1 |
| Di Maio, R | 2 |
| Müller, C | 1 |
| Averkin, RG | 1 |
| Bellistri, E | 1 |
| Miklitz, C | 1 |
| Remy, S | 2 |
| Menendez de la Prida, L | 2 |
| Meng, XD | 1 |
| Wei, D | 3 |
| Kang, JJ | 1 |
| Wu, C | 2 |
| Zhu, GM | 1 |
| Ou-Yang, TP | 1 |
| Liu, YY | 2 |
| Lv, Y | 2 |
| Deng, W | 2 |
| Peng, X | 4 |
| Xi, Z | 2 |
| Chen, G | 11 |
| Ostrin, LA | 1 |
| Garcia, MB | 1 |
| Choh, V | 1 |
| Wildsoet, CF | 1 |
| Buchanan, GF | 1 |
| Murray, NM | 1 |
| Hajek, MA | 1 |
| Richerson, GB | 1 |
| Hung, YW | 2 |
| Hung, SW | 1 |
| Wu, YC | 1 |
| Wong, LK | 1 |
| Lai, MT | 1 |
| Shih, YH | 3 |
| Lee, TS | 2 |
| Lin, YY | 4 |
| Dawidowski, M | 1 |
| Chońska, J | 1 |
| Mika, W | 1 |
| Turło, J | 1 |
| Kouis, P | 1 |
| Mikroulis, A | 1 |
| Psarropoulou, C | 1 |
| Eftekhari, S | 1 |
| Soleimani, M | 1 |
| Hassanzadeh, G | 1 |
| Shahrokhi, A | 1 |
| Mostafavi, H | 1 |
| Hayat, P | 1 |
| Mehdizadeh, H | 1 |
| Rahmanzadeh, R | 1 |
| Hadjighassem, MR | 2 |
| Joghataei, MT | 1 |
| Yamawaki, R | 5 |
| Thind, K | 2 |
| Orban, BO | 1 |
| Routh, VH | 1 |
| Levin, BE | 1 |
| Berlin, JR | 1 |
| VonDran, MW | 1 |
| LaFrancois, J | 1 |
| Padow, VA | 1 |
| Friedman, WJ | 2 |
| Milner, TA | 1 |
| Hempstead, BL | 2 |
| Ribeiro, LR | 3 |
| Pereira, LM | 2 |
| de Oliveira, CV | 2 |
| Vieira, MJ | 1 |
| Argaãaraz, GA | 1 |
| Graça Naffah-Mazzacoratti, Md | 1 |
| van der Hel, WS | 1 |
| Hessel, EV | 1 |
| Bos, IW | 1 |
| Mulder, SD | 1 |
| Verlinde, SA | 1 |
| van Eijsden, P | 2 |
| de Graan, PN | 2 |
| Ahmad, M | 2 |
| Wadaan, MA | 1 |
| Hansen, KF | 2 |
| Sakamoto, K | 1 |
| Pelz, C | 1 |
| Impey, S | 2 |
| Obrietan, K | 4 |
| Fang, F | 1 |
| Huang, F | 1 |
| Xie, R | 1 |
| Qu, J | 1 |
| Zhou, X | 6 |
| Töllner, K | 6 |
| Erker, T | 2 |
| Mercado-Gómez, O | 1 |
| Landgrave-Gómez, J | 1 |
| Arriaga-Avila, V | 1 |
| Nebreda-Corona, A | 1 |
| Guevara-Guzmán, R | 2 |
| Kim, JH | 4 |
| Lee, DW | 1 |
| Sohn, M | 3 |
| Trandafir, CC | 1 |
| Pouliot, WA | 2 |
| Razali, N | 1 |
| Agarwal, R | 2 |
| Agarwal, P | 1 |
| Kapitonova, MY | 1 |
| Kannan Kutty, M | 1 |
| Smirnov, A | 1 |
| Salmah Bakar, N | 1 |
| Ismail, NM | 1 |
| Thamattoor, AK | 2 |
| LeRoy, C | 7 |
| Xu, Z | 3 |
| Xu, P | 2 |
| Fang, M | 4 |
| Yi, F | 2 |
| DeCan, E | 1 |
| Stoll, K | 1 |
| Marceau, E | 1 |
| Deisseroth, K | 2 |
| Lawrence, JJ | 1 |
| Grosser, S | 1 |
| Hollnagel, JO | 1 |
| Gilling, KE | 1 |
| Bartsch, JC | 1 |
| Behr, J | 2 |
| Leung, A | 1 |
| Ahn, S | 1 |
| Savvidis, G | 1 |
| Kim, Y | 1 |
| Iskandar, D | 1 |
| Luna, MJ | 1 |
| Kim, KS | 2 |
| Cunningham, M | 1 |
| Chung, S | 1 |
| Wang, D | 4 |
| Ren, M | 2 |
| Guo, J | 3 |
| Yang, G | 2 |
| Long, X | 3 |
| Hu, R | 2 |
| Shen, W | 2 |
| Zeng, K | 2 |
| de Cristóbal, J | 2 |
| Klee, R | 3 |
| Bröer, S | 1 |
| Orozco-Suárez, SA | 2 |
| Tavares, JG | 1 |
| Vasques, ER | 1 |
| Cabral, FR | 4 |
| Torres, LB | 2 |
| Menezes-Rodrigues, FS | 1 |
| Jurkiewicz, A | 1 |
| Caricati-Neto, A | 1 |
| Godoy, CM | 1 |
| Gomes da Silva, S | 4 |
| Yang, MS | 2 |
| Quan, Y | 2 |
| Gueorguieva, P | 1 |
| Ganesh, T | 4 |
| Dingledine, R | 10 |
| Romanov, A | 1 |
| Isaev, D | 1 |
| Figueiredo, KA | 1 |
| Medeiros, SC | 1 |
| Neves, JK | 1 |
| da Silva, JA | 1 |
| da Rocha Tomé, A | 1 |
| Carvalho, AL | 1 |
| de Freitas, RM | 5 |
| Yasuda, K | 1 |
| Abe, H | 1 |
| Koganemaru, G | 1 |
| Ikeda, T | 1 |
| Arimori, K | 1 |
| Ishida, Y | 1 |
| Zanirati, G | 2 |
| Azevedo, PN | 1 |
| Marinowic, DR | 2 |
| Rodrigues, F | 1 |
| de Oliveira Dias, AC | 1 |
| Venturin, GT | 2 |
| Greggio, S | 2 |
| Simão, F | 1 |
| DaCosta, JC | 3 |
| Salami, P | 1 |
| Gotman, J | 3 |
| Benson, MJ | 3 |
| Thomas, NK | 1 |
| Talwar, S | 1 |
| Hodson, MP | 1 |
| Lynch, JW | 1 |
| Woodruff, TM | 1 |
| Wu, XL | 1 |
| Tang, YC | 6 |
| Lu, QY | 1 |
| Xiao, XL | 2 |
| Song, TB | 1 |
| Tang, FR | 12 |
| He, F | 2 |
| Deng, X | 2 |
| Fu, Y | 1 |
| Joe, E | 1 |
| Lima, IV | 1 |
| Campos, AC | 2 |
| Miranda, AS | 1 |
| Vieira, ÉL | 1 |
| Amaral-Martins, F | 1 |
| Vago, JP | 1 |
| Santos, RP | 1 |
| Sousa, LP | 1 |
| Vieira, LB | 1 |
| Teixeira, MM | 1 |
| Fiebich, BL | 1 |
| Teixeira, AL | 1 |
| de Oliveira, AC | 1 |
| Römermann, K | 2 |
| Bernard, C | 4 |
| Cea-Del Rio, CA | 1 |
| Laoprasert, RP | 1 |
| Huntsman, MM | 1 |
| Brooks-Kayal, A | 1 |
| Inamine, M | 1 |
| Oshima, W | 1 |
| Kotani, M | 1 |
| Chiba, Y | 1 |
| Ueno, M | 1 |
| Yang, X | 1 |
| Xu, X | 1 |
| Li, M | 1 |
| Alsharafi, W | 1 |
| Ito, N | 1 |
| Tafacory, F | 1 |
| Good, L | 1 |
| Ure, K | 1 |
| Kernie, SG | 1 |
| Birnbaum, SG | 1 |
| Eisch, AJ | 1 |
| Manzanero, S | 2 |
| D'Amour, J | 1 |
| Magagna-Poveda, A | 1 |
| Moretto, J | 1 |
| Pearce, P | 2 |
| Nejm, MB | 1 |
| Haidar, AA | 1 |
| Marques, MJ | 1 |
| Hirata, AE | 1 |
| Nogueira, FN | 2 |
| Toyoda, I | 2 |
| Fujita, S | 2 |
| Della-Pace, ID | 1 |
| Li, MQ | 1 |
| Zhang, WW | 1 |
| Lucchi, C | 1 |
| Meletti, S | 1 |
| Jefferys, J | 1 |
| Steinhäuser, C | 1 |
| Bedner, P | 1 |
| Portelli, J | 5 |
| Meurs, A | 8 |
| Bihel, F | 1 |
| Hammoud, H | 1 |
| Schmitt, M | 1 |
| De Kock, J | 1 |
| Utard, V | 1 |
| Humbert, JP | 1 |
| Bertin, I | 1 |
| Buffel, I | 1 |
| Coppens, J | 2 |
| Tourwe, D | 1 |
| Maes, V | 1 |
| De Prins, A | 1 |
| Vanhaecke, T | 1 |
| Massie, A | 3 |
| Balasubramaniam, A | 1 |
| Boon, P | 3 |
| Bourguignon, JJ | 1 |
| Simonin, F | 1 |
| Saffarzadeh, F | 2 |
| Eslamizade, MJ | 2 |
| Ghadiri, T | 1 |
| Modarres Mousavi, SM | 1 |
| Hadjighassem, M | 1 |
| Gorji, A | 2 |
| Lee, DY | 1 |
| Lopes, MW | 3 |
| Lopes, SC | 2 |
| Gonçalves, FM | 2 |
| Rieger, DK | 1 |
| Peres, TV | 1 |
| Eyng, H | 1 |
| Prediger, RD | 2 |
| Diaz, AP | 1 |
| Nunes, JC | 2 |
| Walz, R | 5 |
| Leal, RB | 3 |
| Alcántara-González, D | 2 |
| Bañuelos-Cabrera, I | 1 |
| Magdaleno-Madrigal, V | 1 |
| Fernández-Mas, R | 2 |
| Pessoa, D | 1 |
| Cruz, R | 1 |
| Machado, B | 1 |
| Tenorio, B | 1 |
| Nogueira, R | 1 |
| Kim, JY | 4 |
| Hyun, HW | 3 |
| Katki, K | 1 |
| Shapiro, LA | 2 |
| Gibon, J | 1 |
| Buckley, SM | 1 |
| Unsain, N | 2 |
| Kaartinen, V | 1 |
| Séguéla, P | 1 |
| Barker, PA | 1 |
| Carletti, F | 1 |
| Gambino, G | 1 |
| Rizzo, V | 1 |
| Ferraro, G | 1 |
| Sardo, P | 1 |
| Liang, LP | 3 |
| Day, BJ | 1 |
| Villalpando-Vargas, F | 1 |
| Ragsdale, D | 1 |
| Jagirdar, R | 1 |
| Drexel, M | 1 |
| Kirchmair, E | 1 |
| Tasan, RO | 1 |
| Sperk, G | 1 |
| Brar, J | 1 |
| Ross, BM | 1 |
| Tran, CA | 1 |
| Lusardi, TA | 1 |
| Akula, KK | 1 |
| Coffman, SQ | 1 |
| Ruskin, DN | 1 |
| Masino, SA | 1 |
| Boison, D | 1 |
| Muldoon, SF | 1 |
| Villette, V | 1 |
| Tressard, T | 1 |
| Malvache, A | 1 |
| Reichinnek, S | 1 |
| Bartolomei, F | 3 |
| Cossart, R | 1 |
| Cao, Q | 1 |
| Wang, N | 2 |
| Kim, YJ | 1 |
| Frolova, EV | 1 |
| Sizov, VV | 1 |
| Lavrentyeva, VV | 1 |
| Lukomskaya, NY | 1 |
| Kim, KKh | 2 |
| Ferreira, E | 1 |
| Brito, JG | 1 |
| Nunes, DP | 1 |
| de Morais, DG | 1 |
| Nobrega, JN | 1 |
| deAlmeida, AC | 1 |
| Hillert, MH | 1 |
| Carrasco-Pozo, C | 1 |
| Seeburg, DP | 1 |
| Pulli, B | 1 |
| Wojtkiewicz, GR | 1 |
| Bure, L | 1 |
| Atkinson, W | 1 |
| Schob, S | 1 |
| Iwamoto, Y | 1 |
| Ali, M | 1 |
| Rodriguez, E | 1 |
| Milewski, A | 1 |
| Keliher, EJ | 1 |
| Pan, Y | 2 |
| Swirski, FK | 1 |
| Chen, JW | 1 |
| Shen, H | 1 |
| Dubey, D | 2 |
| Bermudez, C | 1 |
| Porter, BE | 4 |
| Karlócai, MR | 1 |
| Wittner, L | 1 |
| Tóth, K | 2 |
| Maglóczky, Z | 2 |
| Katarova, Z | 1 |
| Rásonyi, G | 2 |
| Erőss, L | 2 |
| Czirják, S | 2 |
| Halász, P | 2 |
| Szabó, G | 1 |
| Payne, JA | 1 |
| Kaila, K | 1 |
| Freund, TF | 2 |
| Rezende, GH | 2 |
| Guidine, PA | 2 |
| Moraes-Santos, T | 1 |
| Shwe, UT | 2 |
| Williams, DK | 1 |
| Greenfield, LJ | 1 |
| Hu, Q | 1 |
| Zhang, Q | 1 |
| Hong, S | 2 |
| Tang, X | 1 |
| Li, K | 2 |
| Wolf, DC | 1 |
| Bueno-Júnior, LS | 1 |
| Lopes-Aguiar, C | 1 |
| Do Val Da Silva, RA | 1 |
| Kandratavicius, L | 2 |
| Leite, JP | 5 |
| Royeck, M | 1 |
| Kelly, T | 1 |
| Otte, DM | 1 |
| Rennhack, A | 1 |
| Woitecki, A | 1 |
| Becker, A | 4 |
| Kaupp, UB | 1 |
| Rankovic, V | 1 |
| Schidlitzki, A | 2 |
| Xiong, T | 1 |
| Dai, G | 1 |
| Hou, Y | 1 |
| Tan, B | 1 |
| Liu, H | 2 |
| Xing, H | 2 |
| Su, Z | 1 |
| Guo, S | 1 |
| Mousavi, SM | 1 |
| Abraki, SB | 1 |
| Althaus, AL | 1 |
| Chen, X | 2 |
| Dong, G | 1 |
| Zheng, C | 1 |
| Yun, W | 1 |
| Sun, HY | 1 |
| Gulyaev, MV | 1 |
| Abbasova, KR | 1 |
| Sun, HL | 3 |
| Deng, DP | 1 |
| Pan, XH | 2 |
| Wang, CY | 2 |
| Zhang, XL | 1 |
| Chen, XM | 2 |
| Wang, CH | 1 |
| Liu, YX | 1 |
| Li, SC | 1 |
| Bai, XY | 1 |
| Torolira, D | 1 |
| Huang, PY | 2 |
| Tseng, YJ | 1 |
| Ko, TL | 1 |
| Fu, YS | 1 |
| Ma, LM | 1 |
| Yuan, JX | 1 |
| Li, RH | 1 |
| Li, JN | 1 |
| Chen, YM | 1 |
| Benini, R | 3 |
| Roth, R | 1 |
| Khoja, Z | 1 |
| Wintermark, P | 1 |
| Santos, DB | 1 |
| de Mello, N | 2 |
| Liang, JJ | 1 |
| Huang, LF | 1 |
| Pan, SQ | 1 |
| Lu, ZN | 1 |
| Xiao, ZM | 1 |
| Romero, AC | 1 |
| Bergamaschi, CT | 1 |
| de Souza, DN | 1 |
| Schreppel, P | 1 |
| Twele, F | 2 |
| Doná, F | 3 |
| Conceição, IM | 2 |
| Ulrich, H | 2 |
| Ribeiro, EB | 1 |
| Freitas, TA | 1 |
| Nencioni, AL | 1 |
| da Silva Fernandes, MJ | 3 |
| Wang, G | 1 |
| Wei, M | 1 |
| Ma, S | 1 |
| Che, N | 1 |
| Yao, J | 1 |
| Yin, J | 1 |
| Santos, VR | 1 |
| Singh, SP | 1 |
| Rolle, IJ | 1 |
| LaSarge, CL | 1 |
| Tian, Q | 1 |
| Gu, M | 1 |
| Hofmann, G | 1 |
| Balgooyen, L | 1 |
| Mattis, J | 1 |
| Łączkowski, KZ | 1 |
| Sałat, K | 1 |
| Misiura, K | 1 |
| Podkowa, A | 1 |
| Malikowska, N | 1 |
| Veniaminova, EA | 1 |
| Otsuka, S | 1 |
| Ohkido, T | 1 |
| Itakura, M | 1 |
| Yamamori, S | 1 |
| Iida, Y | 1 |
| Thyrion, L | 1 |
| Raedt, R | 2 |
| Glorieux, G | 1 |
| Larsen, LE | 1 |
| Sprengers, M | 1 |
| Van Lysebettens, W | 1 |
| Carrette, E | 2 |
| Delbeke, J | 1 |
| Vonck, K | 2 |
| Qin, J | 1 |
| Chen, B | 2 |
| Ni, G | 1 |
| Ning, Y | 1 |
| Cardim, DA | 1 |
| Frigieri, GH | 1 |
| Cabella, BC | 1 |
| Cardim, AC | 1 |
| Wang, CC | 1 |
| de Albuquerque Pacheco Andrade, R | 1 |
| Mascarenhas, S | 1 |
| Álvarez-Croda, DM | 1 |
| Santiago-García, J | 1 |
| Martínez-Quiroz, J | 1 |
| Puig-Lagunes, AA | 1 |
| Vainchtein, ID | 1 |
| Spano, C | 1 |
| Giordano, C | 1 |
| Bordini, D | 1 |
| Curia, G | 2 |
| Dominici, M | 1 |
| Boddeke, HW | 1 |
| Eggen, BJ | 1 |
| Sun, D | 1 |
| Yue, Z | 1 |
| Tang, W | 1 |
| Szczurowska, E | 1 |
| Ergang, P | 1 |
| Druga, R | 5 |
| Salaj, M | 1 |
| Lai, Y | 2 |
| Zhu, B | 3 |
| Choi, YS | 3 |
| Lee, B | 2 |
| Aten, S | 1 |
| Horning, P | 1 |
| Wheaton, KL | 1 |
| Hoyt, KR | 2 |
| Nolan, E | 1 |
| Vaillant, F | 1 |
| Branstetter, D | 1 |
| Pal, B | 1 |
| Giner, G | 1 |
| Whitehead, L | 1 |
| Lok, SW | 1 |
| Mann, GB | 1 |
| Rohrbach, K | 1 |
| Huang, LY | 1 |
| Soriano, R | 1 |
| Smyth, GK | 1 |
| Dougall, WC | 1 |
| Visvader, JE | 1 |
| Lindeman, GJ | 1 |
| Rozmer, K | 1 |
| Gao, P | 1 |
| Araújo, MGL | 1 |
| Khan, MT | 1 |
| Rong, W | 1 |
| Tang, Y | 1 |
| Franke, H | 1 |
| Krügel, U | 1 |
| Fernandes, MJS | 1 |
| Illes, P | 1 |
| Ge, YX | 1 |
| Tian, XZ | 1 |
| Liu, XY | 1 |
| Karunakaran, S | 1 |
| Grasse, DW | 1 |
| Moxon, KA | 1 |
| Do Val-da Silva, RA | 1 |
| Peixoto-Santos, JE | 2 |
| Scandiuzzi, RC | 1 |
| Balista, PA | 1 |
| Bassi, M | 1 |
| Glass, ML | 1 |
| Romcy-Pereira, RN | 1 |
| Galvis-Alonso, OY | 1 |
| Cai, J | 1 |
| Song, B | 1 |
| Pontes, JC | 1 |
| Lima, TZ | 1 |
| Cinini, SM | 2 |
| Blanco, MM | 4 |
| Cao, X | 1 |
| Gulec Suyen, G | 1 |
| Isbil-Buyukcoskun, N | 1 |
| Kahveci, N | 1 |
| Sengun, E | 1 |
| Ozluk, K | 1 |
| Coelho, VR | 1 |
| Vieira, CG | 1 |
| de Souza, LP | 1 |
| Papke, DK | 1 |
| González-Reyes, S | 1 |
| Santillán-Cigales, JJ | 1 |
| Jiménez-Osorio, AS | 1 |
| Pedraza-Chaverri, J | 1 |
| Kryukov, KA | 1 |
| Kim, KK | 1 |
| Fu, P | 1 |
| Wen, Y | 1 |
| Shangaraeva, VA | 1 |
| van Rijn, CM | 1 |
| Bahbiti, Y | 1 |
| Ammouri, H | 1 |
| Berkiks, I | 1 |
| Hessni, AE | 1 |
| Ouichou, A | 1 |
| Nakache, R | 1 |
| Chakit, M | 1 |
| Bikjdaouene, L | 1 |
| Mesfioui, A | 1 |
| Zang, Z | 1 |
| Min, SJ | 2 |
| Kim, MJ | 3 |
| Shao, H | 2 |
| Mi, Z | 1 |
| Zhu, GX | 2 |
| Qi, AP | 2 |
| Ji, WG | 2 |
| Zhu, ZR | 2 |
| Araújo, MA | 1 |
| Octacílio-Silva, S | 1 |
| Arroxelas-Silva, CL | 1 |
| Castro, OW | 2 |
| Passos, GA | 1 |
| Góes Gitaí, DL | 1 |
| Chak, K | 1 |
| Roy-Chaudhuri, B | 1 |
| Kim, HK | 2 |
| Kemp, KC | 1 |
| Kay, MA | 1 |
| Alsharafi, WA | 2 |
| Lima, IVA | 1 |
| Bellozi, PMQ | 1 |
| Doria, JG | 1 |
| Ribeiro, FM | 1 |
| Moraes, MFD | 1 |
| de Oliveira, ACP | 1 |
| Hong, P | 1 |
| Cao, XY | 1 |
| Albright, B | 1 |
| Dhaher, R | 1 |
| Harb, R | 1 |
| Lee, TW | 1 |
| Zaveri, H | 1 |
| Eid, T | 1 |
| Romariz, SA | 1 |
| Paiva, DS | 1 |
| Galindo, LT | 1 |
| Barnabé, GF | 1 |
| Guedes, VA | 1 |
| Borlongan, CV | 1 |
| Vannucci Campos, D | 2 |
| Lopim, GM | 2 |
| de Almeida, VS | 1 |
| Wolff, C | 1 |
| Gao, B | 1 |
| Liang, S | 1 |
| Warren, E | 1 |
| Roberts, LJ | 1 |
| Zhai, X | 1 |
| Ma, J | 1 |
| Mock, MM | 1 |
| Abramowitz, J | 1 |
| Morin, L | 1 |
| Enderlin, J | 1 |
| Leger, PL | 1 |
| Perrotte, G | 1 |
| Bonnin, P | 1 |
| Dupuis, N | 1 |
| Baud, O | 1 |
| Charriaut-Marlangue, C | 1 |
| Auvin, S | 6 |
| Motaghi, S | 1 |
| Babapour, V | 1 |
| Mahdian, R | 1 |
| Rojas, A | 2 |
| Yi, PL | 1 |
| Jou, SB | 1 |
| Chang, FC | 1 |
| da Silva, DA | 1 |
| de Almeida, AA | 4 |
| Sarfi, M | 1 |
| Elahdadi Salmani, M | 1 |
| Goudarzi, I | 1 |
| Lashkar Boluki, T | 1 |
| Abrari, K | 1 |
| Kawashima, F | 1 |
| Kurata, H | 1 |
| Maegaki, Y | 1 |
| Mori, T | 1 |
| Lee, DJ | 1 |
| Izadi, A | 1 |
| Melnik, M | 1 |
| Seidl, S | 1 |
| Echeverri, A | 1 |
| Shahlaie, K | 1 |
| Gurkoff, GG | 1 |
| Gross, A | 1 |
| Madar, R | 1 |
| Illouz, T | 1 |
| Griffioen, K | 1 |
| Steiner, I | 1 |
| Offen, D | 1 |
| Okun, E | 1 |
| Talevi, A | 1 |
| Bruno-Blanch, L | 1 |
| Magdaleno-Madrigal, VM | 1 |
| He, R | 1 |
| Eavey, R | 1 |
| Marques, MJG | 1 |
| Lam, PM | 1 |
| Tang, L | 1 |
| Tao, H | 2 |
| Liu, T | 2 |
| Cai, Y | 2 |
| Yin, M | 1 |
| Zhong, W | 1 |
| Zhao, B | 1 |
| Cui, L | 1 |
| Gurd, JW | 3 |
| Rawof, S | 1 |
| Zhen Huo, J | 1 |
| Dykstra, C | 1 |
| Bissoon, N | 2 |
| Teves, L | 1 |
| Wallace, MC | 1 |
| Rostas, JA | 1 |
| Gearing, M | 2 |
| Rittling, S | 1 |
| Sorensen, ES | 1 |
| Kotloski, R | 1 |
| Denhardt, DT | 1 |
| Cardoso, A | 3 |
| Madeira, MD | 1 |
| Paula-Barbosa, MM | 1 |
| Lukoyanov, NV | 3 |
| Longo, D | 4 |
| Jones, RS | 1 |
| N'Gouemo, P | 2 |
| Tiedje, KE | 1 |
| Weaver, DF | 3 |
| Ermolinsky, B | 3 |
| Pacheco Otalora, LF | 5 |
| Arshadmansab, MF | 5 |
| Zarei, MM | 2 |
| Garrido-Sanabria, ER | 7 |
| Zhao, R | 2 |
| Zhang, XY | 2 |
| Weng, CC | 2 |
| Jiang, LL | 1 |
| Zhang, JW | 1 |
| Shu, XQ | 1 |
| Ji, YH | 2 |
| Baldelli, E | 6 |
| Contri, MB | 1 |
| Guerrini, U | 1 |
| Sironi, L | 1 |
| Gelosa, P | 1 |
| Zini, I | 1 |
| Ragsdale, DS | 2 |
| Hanaya, R | 2 |
| Kamida, T | 2 |
| Fujiki, M | 2 |
| Ooba, H | 1 |
| Anan, M | 1 |
| Abe, T | 2 |
| Kobayashi, H | 2 |
| Houser, CR | 8 |
| Huang, CS | 2 |
| Peng, Z | 4 |
| Liu, YH | 2 |
| Huang, YG | 4 |
| Chen, LW | 2 |
| Metcalf, CS | 2 |
| Radwanski, PB | 1 |
| Bealer, SL | 2 |
| Monaghan, MM | 1 |
| Menegola, M | 1 |
| Vacher, H | 1 |
| Rhodes, KJ | 1 |
| Trimmer, JS | 1 |
| Lively, S | 2 |
| Brown, IR | 2 |
| Volosin, M | 1 |
| Trotter, C | 2 |
| Cragnolini, A | 1 |
| Kenchappa, RS | 1 |
| Light, M | 1 |
| Carter, BD | 1 |
| Lian, XY | 2 |
| Stringer, JL | 3 |
| Fu, W | 1 |
| Ma, W | 1 |
| Yuan, M | 1 |
| Trindade-Filho, EM | 1 |
| de Castro-Neto, EF | 1 |
| de A Carvalho, R | 1 |
| Lima, E | 2 |
| Naffah-Mazzacoratti, Mda G | 8 |
| Kwak, SE | 6 |
| Choi, KC | 1 |
| Kim, DW | 2 |
| Kwon, OS | 4 |
| Choi, SY | 5 |
| Su, T | 1 |
| Cong, WD | 1 |
| Long, YS | 1 |
| Luo, AH | 1 |
| Sun, WW | 1 |
| Deng, WY | 1 |
| Liao, WP | 1 |
| Zhang, HJ | 1 |
| Lei, GF | 1 |
| Liu, CX | 1 |
| Tiruchinapalli, DM | 1 |
| Caron, MG | 1 |
| Keene, JD | 1 |
| Khanna, S | 1 |
| Sochivko, D | 3 |
| Staniek, M | 1 |
| Chen, CC | 1 |
| Campbell, KP | 1 |
| dos Santos, JG | 1 |
| Perez-Mendes, P | 2 |
| Kohek, SR | 1 |
| Cavarsan, CF | 2 |
| Hummel, M | 1 |
| Albuquerque, C | 1 |
| Porta, N | 1 |
| Vallée, L | 1 |
| Lecointe, C | 1 |
| Bouchaert, E | 1 |
| Staels, B | 1 |
| Bordet, R | 1 |
| Kuteykin-Teplyakov, K | 1 |
| Hoffmann, K | 3 |
| Carvalho, LS | 2 |
| Lukoyanova, EA | 1 |
| Persike, DS | 2 |
| Blini, JP | 1 |
| Fernandes, MJ | 3 |
| St-Pierre, LS | 3 |
| Bubenik, GA | 1 |
| Parker, GH | 2 |
| Persinger, MA | 10 |
| Wei, LC | 1 |
| Zoli, M | 1 |
| Bertazzoni, G | 1 |
| Lin, TC | 1 |
| Huang, LT | 3 |
| Huang, YN | 1 |
| Chen, GS | 1 |
| Wang, JY | 1 |
| Lehmkuhle, MJ | 1 |
| Thomson, KE | 1 |
| Scheerlinck, P | 2 |
| Pouliot, W | 2 |
| Greger, B | 1 |
| Marcelin, B | 1 |
| Chauvière, L | 3 |
| Migliore, M | 1 |
| Jo, SM | 3 |
| Cao, R | 2 |
| Cho, HY | 2 |
| Rhee, AD | 1 |
| Hah, CK | 1 |
| Sandow, N | 1 |
| Zahn, RK | 1 |
| Gabriel, S | 3 |
| Lehmann, TN | 3 |
| Andrioli, A | 1 |
| Fabene, PF | 5 |
| Spreafico, R | 2 |
| Bentivoglio, M | 3 |
| Goffin, K | 1 |
| Van Paesschen, W | 1 |
| Dupont, P | 1 |
| Van Laere, K | 1 |
| George, KR | 1 |
| Rico, T | 1 |
| Dupont, MJ | 2 |
| Blomme, CG | 1 |
| Mazzuchin, A | 1 |
| Stewart, LS | 2 |
| Mazarati, AM | 4 |
| Kwon, YS | 1 |
| Bragin, A | 2 |
| Tio, D | 2 |
| Taylor, AN | 2 |
| Young, NA | 1 |
| Vuong, J | 1 |
| Ozen, LJ | 1 |
| Flynn, C | 1 |
| Teskey, GC | 1 |
| Falenski, KW | 2 |
| Carter, DS | 2 |
| Harrison, AJ | 1 |
| Martin, BR | 2 |
| Blair, RE | 3 |
| DeLorenzo, RJ | 7 |
| Wang, NC | 1 |
| Good, LB | 1 |
| Marsh, ST | 1 |
| Treiman, DM | 2 |
| Peternel, S | 1 |
| Pilipović, K | 1 |
| Zupan, G | 1 |
| Malthankar-Phatak, GH | 1 |
| McCloskey, DP | 4 |
| Harden, CL | 1 |
| You, ZL | 1 |
| Zhang, DD | 1 |
| El Yacoubi, M | 1 |
| Ledent, C | 1 |
| Parmentier, M | 1 |
| Costentin, J | 1 |
| Vaugeois, JM | 1 |
| Müller, CJ | 3 |
| Gröticke, I | 3 |
| Schughart, K | 2 |
| Jun, Y | 1 |
| JiangTao, X | 1 |
| YuanGui, H | 1 |
| YongBin, S | 1 |
| Jun, Z | 1 |
| XiaoJun, M | 1 |
| JianChun, X | 1 |
| Heng, X | 1 |
| XiaoXin, Z | 1 |
| XinXiang, X | 1 |
| Bracey, JM | 2 |
| Kurz, JE | 4 |
| Low, B | 1 |
| Churn, SB | 5 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 2 |
| Navarro Mora, G | 1 |
| Bramanti, P | 1 |
| Osculati, F | 1 |
| Chakir, A | 2 |
| Nicolato, E | 1 |
| Marzola, P | 1 |
| Sbarbati, A | 1 |
| Parinejad, N | 1 |
| Keshavarzi, S | 1 |
| Movahedin, M | 1 |
| Raza, M | 2 |
| Ingram, EA | 1 |
| Wen, X | 6 |
| Raffo, E | 2 |
| de Vasconcelos, AP | 1 |
| Boehrer, A | 1 |
| Desor, D | 2 |
| Masuoka, T | 1 |
| Kamei, C | 1 |
| Epsztein, J | 1 |
| Sola, E | 1 |
| Represa, A | 2 |
| Ben-Ari, Y | 3 |
| Montroull, LE | 1 |
| Mascó, DH | 1 |
| Yakushev, IY | 1 |
| Dupont, E | 1 |
| Buchholz, HG | 1 |
| Tillmanns, J | 1 |
| Debus, F | 1 |
| Cumming, P | 1 |
| Heimann, A | 1 |
| Fellgiebel, A | 1 |
| Luhmann, HJ | 1 |
| Landvogt, C | 1 |
| Werhahn, KJ | 1 |
| Schreckenberger, M | 1 |
| Krishnakumar, A | 2 |
| Nandhu, MS | 1 |
| Militão, GC | 1 |
| Ferreira, PM | 1 |
| Zhao, WM | 1 |
| Qi, HP | 1 |
| Chen, W | 1 |
| Xie, J | 1 |
| Pan, ZY | 1 |
| Han, HM | 1 |
| Chen, LP | 1 |
| Li, DL | 1 |
| Wang, LY | 1 |
| Scerni, DA | 1 |
| Calderazzo, L | 5 |
| Poelzing, S | 1 |
| Little, JG | 1 |
| Michotte, Y | 12 |
| Clinckers, R | 10 |
| Marciszko, M | 1 |
| Czyzycki, M | 1 |
| Rickers, K | 1 |
| Peña, F | 1 |
| Neri-Bazan, L | 1 |
| Rocha, LL | 1 |
| Allen, S | 2 |
| Uhl, J | 1 |
| Diaz, J | 1 |
| Prince, DA | 1 |
| Hosoi, R | 1 |
| Kitano, D | 1 |
| Momosaki, S | 1 |
| Kuse, K | 1 |
| Gee, A | 1 |
| Inoue, O | 1 |
| Naylor, DE | 1 |
| Thompson, KW | 1 |
| Baldwin, RA | 1 |
| Loke, WK | 1 |
| Lei, L | 1 |
| Vosters, JL | 1 |
| Landek-Salgado, MA | 1 |
| Yin, H | 3 |
| Swaim, WD | 1 |
| Kimura, H | 1 |
| Tak, PP | 1 |
| Caturegli, P | 1 |
| Chiorini, JA | 1 |
| Bénar, CG | 1 |
| Wendling, F | 2 |
| Collins, LE | 1 |
| Galtieri, DJ | 1 |
| Brennum, LT | 1 |
| Sager, TN | 1 |
| Hockemeyer, J | 1 |
| Hinman, JR | 1 |
| Chrobak, JJ | 1 |
| Terra, VC | 2 |
| Ndode-Ekane, XE | 1 |
| Hayward, N | 1 |
| Gröhn, O | 1 |
| Pitkänen, A | 3 |
| Koshikawa, N | 1 |
| Kobayashi, M | 4 |
| Andreoli, N | 1 |
| Fuxe, K | 1 |
| Agnati, LF | 1 |
| Thind, KK | 2 |
| Phanwar, I | 1 |
| Scorzai, CA | 1 |
| Machado, HR | 1 |
| Zhao, S | 2 |
| Aviles, ER | 2 |
| Fujikawa, DG | 3 |
| Costa-Ferro, ZS | 1 |
| Vitola, AS | 1 |
| Pedroso, MF | 1 |
| Cunha, FB | 1 |
| Xavier, LL | 1 |
| Machado, DC | 2 |
| Soares, MB | 2 |
| Ribeiro-dos-Santos, R | 2 |
| Tsai, R | 1 |
| Baldo, MV | 1 |
| de Castro, I | 1 |
| Sameshima, K | 1 |
| Valle, AC | 1 |
| Bhaskaran, MD | 2 |
| Mathew, J | 3 |
| Peeyush Kumar, T | 1 |
| Khan, RS | 1 |
| Satoh, K | 1 |
| Narita, T | 1 |
| Matsui-Inohara, H | 1 |
| Ito, T | 1 |
| Senpuku, H | 1 |
| Sugiya, H | 1 |
| Cai, GE | 1 |
| Lu, QC | 2 |
| Li, ST | 2 |
| Ju, G | 1 |
| Mirrione, MM | 1 |
| Konomos, DK | 1 |
| Gravanis, I | 1 |
| Dewey, SL | 1 |
| Aguzzi, A | 1 |
| Heppner, FL | 1 |
| Tsirka, SE | 1 |
| Graebenitz, S | 1 |
| Lesting, J | 1 |
| Sosulina, L | 1 |
| Seidenbecher, T | 1 |
| Pape, HC | 1 |
| Lee, JY | 1 |
| Englot, DJ | 1 |
| Gildersleeve, S | 1 |
| Piskorowski, RA | 1 |
| Winawer, MR | 1 |
| Blumenfeld, H | 1 |
| Longo, B | 3 |
| Vasconcelos, JF | 1 |
| Bahia, L | 1 |
| da Silveira, VG | 1 |
| de Paula Cognato, G | 2 |
| Müller, AP | 1 |
| Figueiró, F | 1 |
| Bonan, CD | 2 |
| Perry, ML | 1 |
| Battastini, AM | 1 |
| He, XP | 1 |
| Pan, E | 1 |
| Sciarretta, C | 1 |
| Minichiello, L | 1 |
| McNamara, JO | 2 |
| Sadanandan, J | 1 |
| Panuccio, G | 1 |
| D'Antuono, M | 3 |
| de Guzman, P | 4 |
| De Lannoy, L | 1 |
| Sadaghiani, MM | 1 |
| Zhang, SJ | 1 |
| Li, XW | 2 |
| Bortel, A | 3 |
| Dubeau, F | 1 |
| Skinner, F | 2 |
| Garcia, I | 2 |
| Mello, CF | 2 |
| Knaus, HG | 2 |
| Ermolinsky, BS | 3 |
| Otalora, LF | 1 |
| Wu, J | 2 |
| McMahon, J | 2 |
| Lin, Y | 2 |
| Cao, Z | 1 |
| Gruenthal, M | 1 |
| Nozadze, M | 1 |
| Heuchert, N | 1 |
| Rattka, M | 2 |
| Feng, D | 1 |
| Jordán, J | 1 |
| Wyeth, MS | 1 |
| Zhang, N | 1 |
| Mody, I | 2 |
| Choy, M | 2 |
| Wells, JA | 1 |
| Thomas, DL | 1 |
| Gadian, DG | 2 |
| Marchi, N | 4 |
| Teng, Q | 2 |
| Ghosh, C | 2 |
| Fan, Q | 1 |
| Nguyen, MT | 1 |
| Desai, NK | 1 |
| Bawa, H | 1 |
| Rasmussen, P | 1 |
| Masaryk, TK | 1 |
| Janigro, D | 4 |
| Li, A | 1 |
| Dziema, H | 1 |
| Jung, YJ | 1 |
| Besio, WG | 2 |
| Gale, KN | 1 |
| Medvedev, AV | 1 |
| Karlócai, R | 1 |
| Nagy, S | 1 |
| Vajda, J | 1 |
| Kelemen, A | 1 |
| Juhos, V | 1 |
| Mackie, K | 1 |
| Linard, B | 1 |
| Lu, X | 1 |
| Roberts, E | 1 |
| Xia, F | 1 |
| Sanchez-Alavez, M | 1 |
| Chang, J | 1 |
| Bartfai, T | 1 |
| Kwon, HJ | 1 |
| Avanzi, RD | 1 |
| Santos, JG | 1 |
| do Vale, TG | 1 |
| da Silva, AV | 1 |
| Lima, DC | 1 |
| Cossa, AC | 1 |
| de Oliveira, EM | 1 |
| Parks, GS | 1 |
| Okumura, SM | 1 |
| Gohil, K | 1 |
| Civelli, O | 1 |
| Pestana, RR | 1 |
| Kinjo, ER | 1 |
| Hernandes, MS | 1 |
| Britto, LR | 1 |
| Nicoletti, JN | 1 |
| Lenzer, J | 1 |
| Salerni, EA | 1 |
| Shah, SK | 1 |
| Elkady, A | 1 |
| Khalid, S | 1 |
| Quinteros, D | 1 |
| Rotella, F | 1 |
| Betancourth, D | 1 |
| Croll, SD | 2 |
| Kong, S | 1 |
| Eshima, N | 1 |
| Abuhamed, MM | 1 |
| Bo, X | 1 |
| Jing, L | 1 |
| Long, L | 2 |
| Zhiguo, W | 1 |
| Zhi, S | 1 |
| Rubio, C | 1 |
| Rubio-Osornio, M | 1 |
| Retana-Márquez, S | 1 |
| Verónica Custodio, ML | 1 |
| Paz, C | 1 |
| Cravo, SL | 1 |
| Schoorlemmer, GH | 1 |
| Yeo, SI | 2 |
| Wilhelm, EA | 1 |
| Jesse, CR | 2 |
| Roman, SS | 1 |
| Bortolatto, CF | 1 |
| Nogueira, CW | 2 |
| Martinez, Y | 1 |
| Freitas-da-Costa, P | 1 |
| Farrell, B | 2 |
| Pandari, T | 1 |
| Robles, L | 1 |
| Rosas, G | 1 |
| Zhou, SN | 1 |
| Li, CS | 1 |
| Liu, LQ | 1 |
| Shen, L | 2 |
| Avchalumov, Y | 1 |
| Mutasem, MA | 1 |
| Bi, F | 1 |
| Sun, YP | 1 |
| Xu, YH | 1 |
| Zhao, YS | 1 |
| Deshpande, LS | 1 |
| Rafiq, A | 3 |
| Sombati, S | 1 |
| Murphy, BL | 1 |
| Pun, RY | 1 |
| Faulkner, CR | 1 |
| Loepke, AW | 1 |
| Waldbaum, S | 1 |
| Furtado, MA | 2 |
| Del Vecchio, F | 3 |
| de Oliveira, JA | 1 |
| Sterin-Borda, L | 1 |
| Orman, B | 1 |
| De Couto Pita, A | 1 |
| Borda, E | 1 |
| Feng, Q | 1 |
| Zhu, HY | 1 |
| Mollet, L | 1 |
| El Tahry, R | 1 |
| Wyckhuys, T | 1 |
| De Herdt, V | 1 |
| Wadman, W | 1 |
| Chen, D | 1 |
| Lee, KE | 1 |
| Châtillon, CÉ | 1 |
| Zelmann, R | 1 |
| Cameron, MC | 1 |
| Zhan, RZ | 1 |
| Nadler, JV | 4 |
| Granata, T | 1 |
| Freri, E | 1 |
| Ciusani, E | 1 |
| Ragona, F | 1 |
| Puvenna, V | 2 |
| Alexopolous, A | 1 |
| Seo, CH | 1 |
| Lee, BC | 1 |
| Choi, IG | 1 |
| Finardi, A | 1 |
| Frasca, A | 1 |
| Balosso, S | 1 |
| Carriero, G | 1 |
| Battaglia, G | 1 |
| Bachiega, J | 1 |
| Papoti, D | 1 |
| Pierre, K | 1 |
| Simpson, IA | 1 |
| Pellerin, L | 1 |
| Vannucci, SJ | 1 |
| Johnson, AJ | 1 |
| Johnson, HL | 1 |
| Tierney, W | 1 |
| Cucullo, L | 1 |
| Zhu, Q | 4 |
| Zhao, F | 3 |
| Kuntner, C | 1 |
| Stanek, J | 1 |
| Wanek, T | 1 |
| Meier, M | 1 |
| Ding, XQ | 1 |
| Müller, M | 1 |
| Langer, O | 1 |
| Tiraihi, T | 1 |
| Cammarota, M | 1 |
| Jaworska-Adamu, J | 1 |
| Dmowska, M | 1 |
| Cybulska, R | 1 |
| Krawczyk, A | 1 |
| Pawlikowska-Pawlęga, B | 1 |
| Cifelli, P | 1 |
| Grace, AA | 1 |
| Kang, KM | 2 |
| Kim, S | 1 |
| Seo, JS | 1 |
| Won, CH | 1 |
| Roh, JK | 4 |
| Wilde, M | 1 |
| Damaye, CA | 1 |
| Lan, Y | 1 |
| Walijee, SM | 1 |
| Inostroza, M | 1 |
| Cid, E | 1 |
| Brotons-Mas, J | 1 |
| Gal, B | 1 |
| Aivar, P | 1 |
| Uzcategui, YG | 1 |
| Sandi, C | 1 |
| Xue, T | 1 |
| Lei, X | 1 |
| Silva Araújo, BH | 2 |
| Choi, HK | 1 |
| Rosim, FE | 1 |
| Amorim, RP | 1 |
| de Oliveira, DM | 1 |
| Stragier, B | 1 |
| Han, Y | 2 |
| Rui, C | 1 |
| Xu, J | 2 |
| Cao, L | 1 |
| Chi, Z | 1 |
| Zhou, C | 1 |
| Mikkat, U | 1 |
| Barmashenko, G | 1 |
| Hefft, S | 1 |
| Aertsen, A | 1 |
| Priel, MR | 5 |
| Brito Torres, L | 1 |
| Gurgel do Vale, T | 1 |
| Pereira, F | 1 |
| Alves de Amorim, H | 1 |
| Abrão Cavalheiro, E | 3 |
| Amado Scerni, D | 1 |
| Torsello, A | 1 |
| Marinelli, C | 1 |
| Vezzali, R | 1 |
| Coco, S | 1 |
| Bresciani, E | 1 |
| Locatelli, V | 1 |
| Xin, Y | 1 |
| HaiQin, W | 1 |
| GuiLian, Z | 1 |
| Ru, Z | 1 |
| ShuQin, Z | 1 |
| HuQing, W | 1 |
| Yun, D | 1 |
| Vermoesen, K | 3 |
| Serruys, AS | 1 |
| Loyens, E | 3 |
| Afrikanova, T | 1 |
| Schallier, A | 3 |
| Crawford, AD | 1 |
| Esguerra, CV | 1 |
| de Witte, PA | 1 |
| Yang, DI | 1 |
| Kuo, TB | 1 |
| Yiu, CH | 1 |
| Serrano, GE | 1 |
| Lelutiu, N | 1 |
| Cochi, S | 1 |
| Shaw, R | 1 |
| Makinson, CD | 1 |
| FitzGerald, GA | 1 |
| Tawfik, MK | 1 |
| Ruiz, N | 1 |
| Pacheco, LF | 1 |
| Cox, CB | 1 |
| Nair, S | 1 |
| Júnior, JS | 1 |
| Tomé, Ada R | 1 |
| Citó, AM | 1 |
| Saffi, J | 1 |
| Baraka, AM | 1 |
| Hassab El Nabi, W | 1 |
| El Ghotni, S | 1 |
| Lew, FH | 1 |
| Tan, GH | 1 |
| Hu, XL | 1 |
| Yin, DM | 1 |
| Mei, L | 1 |
| Xiong, ZQ | 1 |
| Li, KX | 1 |
| Lu, YM | 1 |
| Xu, ZH | 1 |
| Zhu, JM | 1 |
| Zhang, JM | 1 |
| Cao, SX | 1 |
| Chen, XJ | 1 |
| Luo, JH | 1 |
| Duan, S | 1 |
| Chow, JC | 1 |
| Al-Shorbagy, MY | 1 |
| El Sayeh, BM | 1 |
| Abdallah, DM | 1 |
| Ma, DL | 4 |
| Ling, EA | 1 |
| Wilk, E | 1 |
| Balakrishnan, S | 1 |
| Abraham, PM | 1 |
| Kukley, M | 1 |
| Brewster, A | 1 |
| Rüschenschmidt, C | 3 |
| Schramm, J | 3 |
| Baram, TZ | 1 |
| Lee, EM | 1 |
| Park, GY | 1 |
| Im, KC | 1 |
| Kim, ST | 1 |
| Woo, CW | 1 |
| Chung, JH | 1 |
| Kim, JS | 2 |
| Shon, YM | 1 |
| Kang, JK | 1 |
| Sayers, KW | 1 |
| Nguyen, PT | 1 |
| Sim-Selley, LJ | 1 |
| Yang, Z | 1 |
| Yin, Y | 1 |
| Sun, S | 1 |
| Cho, KS | 1 |
| Yu, D | 1 |
| Wang, WH | 2 |
| Luo, G | 1 |
| Pang, IH | 2 |
| Guo, W | 1 |
| Chen, DF | 1 |
| Alvarenga, TA | 2 |
| Akhtari, M | 1 |
| Moats, R | 1 |
| Frew, A | 1 |
| Mandelkern, M | 1 |
| Paiva, FF | 1 |
| Silva, AC | 1 |
| Hao, Y | 1 |
| Xu, L | 1 |
| Hong, Z | 1 |
| Thielemans, L | 1 |
| Ver Donck, L | 1 |
| Aerssens, J | 1 |
| Moechars, D | 1 |
| Collingridge, GL | 2 |
| Bortolotto, ZA | 6 |
| Omran, A | 1 |
| Xiang, QL | 1 |
| Xue, J | 1 |
| Doublet, T | 1 |
| Ghestem, A | 1 |
| Siyoucef, SS | 1 |
| Huys, R | 1 |
| Jirsa, V | 1 |
| Pilli, J | 1 |
| Abbasi, S | 1 |
| Richardson, M | 1 |
| Kumar, SS | 3 |
| Lee, CY | 1 |
| Jaw, T | 1 |
| Tseng, HC | 1 |
| Chen, IC | 1 |
| Liou, HH | 1 |
| do Nascimento, AL | 1 |
| Dos Santos, NF | 2 |
| Campos Pelágio, F | 1 |
| Aparecida Teixeira, S | 1 |
| de Moraes Ferrari, EA | 1 |
| Langone, F | 1 |
| Mastroberardino, PG | 1 |
| Montero, LM | 1 |
| Greenamyre, JT | 1 |
| Tyler, AL | 1 |
| Pardo, M | 1 |
| Schwarzschild, MA | 1 |
| Correa, M | 2 |
| Rospo, C | 1 |
| Mercier, MS | 1 |
| Glyn, SE | 1 |
| Jones, NA | 1 |
| Yamasaki, Y | 1 |
| Futamura, T | 1 |
| Stott, CG | 1 |
| Stephens, GJ | 1 |
| Helgager, J | 1 |
| Liu, G | 1 |
| Xie, YY | 1 |
| Long, HY | 1 |
| Sun, DN | 1 |
| Long, LL | 1 |
| Gzielo-Jurek, K | 1 |
| Uram, L | 1 |
| Appel, K | 1 |
| Simon, R | 1 |
| Peixoto, RT | 1 |
| Kunz, PA | 1 |
| Kwon, H | 1 |
| Mabb, AM | 1 |
| Sabatini, BL | 1 |
| Philpot, BD | 1 |
| Ehlers, MD | 1 |
| Suzuki, K | 1 |
| Hayashi, Y | 1 |
| Nakahara, S | 1 |
| Kumazaki, H | 1 |
| Prox, J | 1 |
| Horiuchi, K | 1 |
| Zeng, M | 1 |
| Tanimura, S | 1 |
| Nishiyama, Y | 1 |
| Osawa, S | 1 |
| Sehara-Fujisawa, A | 1 |
| Saftig, P | 1 |
| Yokoshima, S | 1 |
| Fukuyama, T | 1 |
| Matsuki, N | 1 |
| Koyama, R | 1 |
| Tomita, T | 1 |
| Iwatsubo, T | 1 |
| Peixinho-Pena, LF | 1 |
| Fernandes, J | 1 |
| Novaes Gomes, FG | 1 |
| Cassilhas, R | 1 |
| Venancio, DP | 1 |
| de Mello, MT | 1 |
| Zhang, SH | 1 |
| Feng, B | 1 |
| Zhong, K | 1 |
| Yang, LX | 1 |
| Zhang, SP | 1 |
| Yan, XX | 1 |
| Shelton, J | 1 |
| Deng, SH | 1 |
| Luo, XG | 1 |
| Oddo, S | 1 |
| Laferla, FM | 1 |
| Cai, H | 1 |
| Rose, GM | 1 |
| Patrylo, PR | 1 |
| Wang, YG | 1 |
| Wang, JC | 1 |
| Gao, H | 2 |
| Geng, Z | 1 |
| Seo, J | 1 |
| Kim, BS | 1 |
| Bang, M | 1 |
| Shin, HS | 1 |
| Li, XR | 1 |
| Ju, JG | 1 |
| Zhou, P | 1 |
| Silva, NM | 1 |
| Ern, AL | 1 |
| Piermartiri, TC | 1 |
| Tasca, CI | 1 |
| Gavioli, EC | 1 |
| Lemos, T | 1 |
| Carobrez, AP | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| de Barros Viana, GS | 1 |
| Jang, BG | 1 |
| Kim, HS | 1 |
| Chung, TN | 1 |
| Van Liefferinge, J | 1 |
| Vasconcelos Rios, ER | 1 |
| Moura Rocha, NF | 1 |
| Rodrigues Carvalho, AM | 1 |
| Freire Vasconcelos, L | 1 |
| Leite Dias, M | 1 |
| de Carvalho Lima, CN | 1 |
| Soares Lopes, K | 1 |
| Cavalcante Melo, FH | 1 |
| de França Fonteles, MM | 1 |
| Karbowski, LM | 1 |
| Soares, FM | 1 |
| Cajado, AG | 1 |
| de Brito, D | 1 |
| de Cordova, FM | 1 |
| da Cunha, RM | 1 |
| Furtado, Mde A | 2 |
| Braga, GK | 1 |
| Oliveira, JA | 2 |
| Bregola, G | 1 |
| Armellin, M | 1 |
| Del Piccolo, P | 1 |
| Rodi, D | 1 |
| Tongiorgi, E | 1 |
| Cui, SS | 1 |
| Wallace, AE | 1 |
| Hannesson, DK | 1 |
| Schmued, LC | 1 |
| Saucier, DM | 1 |
| Honer, WG | 1 |
| Corcoran, ME | 1 |
| Bengzon, J | 1 |
| Mohapel, P | 1 |
| Ekdahl, CT | 1 |
| Lindvall, O | 1 |
| Zhang, GF | 1 |
| Jones, DM | 1 |
| Esmaeil, N | 1 |
| Maren, S | 1 |
| Macdonald, RL | 2 |
| Priel, M | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Vanneste-Goemaere, J | 1 |
| Margineanu, DG | 1 |
| Dubé, C | 4 |
| Doherty, JJ | 1 |
| Ke, X | 1 |
| Trinidad, RB | 1 |
| Shinmei, SS | 2 |
| Wu, A | 1 |
| Roch, C | 3 |
| Namer, IJ | 3 |
| Cha, BH | 2 |
| Silveira, DC | 2 |
| Gulec, G | 3 |
| Noyan, B | 4 |
| Scarlatelli-Lima, AV | 1 |
| Magalhães, LH | 1 |
| Doretto, MC | 1 |
| Frahm, C | 1 |
| Stief, F | 1 |
| Zuschratter, W | 1 |
| Draguhn, A | 1 |
| Elliott, RC | 2 |
| Miles, MF | 1 |
| Lowenstein, DH | 3 |
| Rigoulot, MA | 3 |
| Chadi, G | 1 |
| McDermott, DL | 2 |
| Smith, AB | 1 |
| Almonte, AG | 1 |
| Wainer, BH | 1 |
| Urban, BW | 1 |
| Molnár, P | 1 |
| Milhaud, D | 1 |
| Rondouin, G | 1 |
| Lerner-Natoli, M | 1 |
| Bockaert, J | 1 |
| Lafon-Cazal, M | 1 |
| Li, GL | 1 |
| Xie, GJ | 1 |
| Wallace, MJ | 1 |
| Freitas, RM | 3 |
| Bezerra Felipe, CF | 1 |
| Nascimento, VS | 2 |
| Oliveira, AA | 3 |
| Viana, GS | 3 |
| Fonteles, MM | 3 |
| Fattoum, A | 1 |
| Shirao, T | 1 |
| Vielhaber, S | 2 |
| Kudin, AP | 3 |
| Kudina, TA | 1 |
| Stiller, D | 1 |
| Scheich, H | 1 |
| Schoenfeld, A | 1 |
| Feistner, H | 1 |
| Heinze, HJ | 1 |
| Kunz, WS | 3 |
| Agrawal, N | 1 |
| Alonso, A | 1 |
| Zien, A | 1 |
| Normann, S | 1 |
| Wiestler, OD | 1 |
| Blümcke, I | 1 |
| Raol, YS | 1 |
| Hsu, FC | 1 |
| Rana, A | 2 |
| Parsons, JT | 2 |
| Ewerton, FI | 1 |
| Bonilha, SM | 1 |
| Ballester, G | 1 |
| Lozano, AM | 1 |
| Carnevalli, LS | 1 |
| Pereira, CM | 1 |
| Jaqueta, CB | 1 |
| Avedissian, M | 1 |
| Castilho, BA | 1 |
| Lindekens, H | 1 |
| O'Neill, MJ | 2 |
| Lodge, D | 2 |
| Ebinger, G | 6 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Argañaraz, GA | 1 |
| Pessoa, LG | 1 |
| Carvalho, FF | 2 |
| Bascands, JL | 1 |
| Bader, M | 2 |
| da Silva Trindade, E | 1 |
| Pesquero, JB | 2 |
| Loh, YT | 1 |
| Chia, SC | 4 |
| Winokur, RS | 1 |
| Kubal, T | 1 |
| Liu, D | 1 |
| Davis, SF | 1 |
| Lyon, A | 1 |
| Marone, S | 2 |
| Wainman, D | 2 |
| McKay, BE | 3 |
| Cavazos, JE | 1 |
| Jones, SM | 1 |
| Cross, DJ | 1 |
| Adolfo Argañaraz, G | 1 |
| Regina Perosa, S | 1 |
| Cristina Lencioni, E | 1 |
| Antônio Silva, J | 1 |
| Jeong, SW | 1 |
| Song, YM | 1 |
| Rossetti, F | 2 |
| Akman, C | 1 |
| Costa, MS | 1 |
| Funke, MG | 2 |
| de Meis, L | 1 |
| Eidt, S | 1 |
| Kendall, EJ | 1 |
| Obenaus, A | 1 |
| Towfighi, J | 1 |
| Housman, C | 1 |
| Brucklacher, R | 1 |
| Vannucci, RC | 1 |
| Shikhanov, NP | 2 |
| Ivanov, NM | 2 |
| Khovriakov, AV | 1 |
| Casperson, K | 1 |
| McKhann, GM | 1 |
| Krugliakov, PP | 1 |
| Sosunov, AA | 2 |
| Stell, BM | 1 |
| Heida, JG | 1 |
| Boissé, L | 1 |
| Pittman, QJ | 1 |
| Bernardi, RB | 1 |
| Barros, HM | 1 |
| Notenboom, RG | 1 |
| Wu, O | 1 |
| van Nieuwenhuizen, O | 1 |
| Nicolay, K | 1 |
| Braun, KP | 1 |
| Debska-Vielhaber, G | 1 |
| Voutsinos-Porche, B | 1 |
| Kaplan, H | 1 |
| Guenounou, M | 1 |
| Motte, J | 1 |
| Ebert, U | 2 |
| Ishiwari, K | 1 |
| Mingote, S | 1 |
| Trevitt, JT | 1 |
| Carlson, BB | 1 |
| Ferraro, DJ | 1 |
| Williams, PA | 1 |
| Chapman, PL | 1 |
| Clark, AF | 1 |
| Larionov, S | 1 |
| Hoerold, N | 1 |
| Ullmann, C | 1 |
| Knopp, A | 1 |
| Kivi, A | 2 |
| Wozny, C | 1 |
| Niimura, M | 1 |
| Moussa, R | 1 |
| Ikeda-Douglas, C | 1 |
| Milgram, NW | 1 |
| Detour, J | 1 |
| Schroeder, H | 1 |
| Rodrigues, MC | 1 |
| Dal-Cól, ML | 1 |
| Bertti, P | 1 |
| Fernandes, A | 1 |
| Santos, FL | 1 |
| Lyon, AP | 1 |
| Silva, AV | 1 |
| Regondi, MC | 1 |
| Frassoni, C | 1 |
| Soares, JM | 1 |
| del Carmen Sanabria Garrido, Y | 1 |
| Gomes Valente, S | 1 |
| Chada Baracat, E | 1 |
| Peterson, SL | 1 |
| Purvis, RS | 1 |
| Griffith, JW | 1 |
| Galic, MA | 1 |
| Bausch, SB | 1 |
| Garland, JP | 1 |
| Yamada, J | 1 |
| Marini, H | 1 |
| Nogueira, CR | 1 |
| Aguiar, LM | 2 |
| Sousa, FC | 2 |
| Pereira, HA | 1 |
| Vianna, EP | 1 |
| Ferreira, AT | 1 |
| de Amorim Carvalho, R | 1 |
| Barbu, E | 1 |
| Sarvaiya, I | 1 |
| Green, KL | 1 |
| Nevell, TG | 1 |
| Tsibouklis, J | 1 |
| Goodman, JH | 2 |
| Berger, RE | 1 |
| Walling, SG | 1 |
| Mercurio, TC | 1 |
| Stormes, K | 1 |
| de Albuquerque, M | 3 |
| Mendes de Freitas, R | 1 |
| Vasconcelos, SM | 1 |
| Hoexter, MQ | 1 |
| Rosa, PS | 1 |
| Singleton, MW | 1 |
| Holbert, WH | 1 |
| Lee, AT | 1 |
| Pleasure, SJ | 1 |
| Barbaro, NM | 1 |
| Bruno, AN | 1 |
| Vuaden, FC | 1 |
| Sarkis, JJ | 1 |
| Scimemi, A | 1 |
| Schorge, S | 1 |
| Kullmann, DM | 1 |
| Walker, MC | 1 |
| Nasseh, IE | 1 |
| Tengan, CH | 1 |
| Pierce, JP | 2 |
| Melton, J | 1 |
| Punsoni, M | 2 |
| Khovryakov, AV | 1 |
| Kaspersen, K | 1 |
| McCann, GM | 1 |
| Kruglyakov, PP | 1 |
| Chen, PM | 2 |
| Jiang, FL | 2 |
| Burgunder, JM | 2 |
| D'Arcangelo, G | 2 |
| Tancredi, V | 2 |
| Rangel, P | 1 |
| Gomes, PA | 1 |
| Cha, S | 1 |
| Singson, E | 1 |
| Cornelius, J | 1 |
| Yagna, JP | 1 |
| Knot, HJ | 1 |
| Peck, AB | 1 |
| Riazanski, V | 1 |
| Timofeeva, O | 1 |
| Nairismägi, J | 1 |
| Kettunen, MI | 1 |
| Kauppinen, RA | 1 |
| Huo, JZ | 1 |
| Dykstra, CM | 1 |
| Zhao, Q | 4 |
| Marolewski, A | 1 |
| Rusche, JR | 1 |
| Sanabria, ER | 4 |
| D'Andrea Vieira, I | 1 |
| da Silveira Pereira, MF | 1 |
| Faria, LC | 1 |
| da Silva, AC | 1 |
| Simola, N | 1 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Morelli, M | 1 |
| Santiago, JF | 1 |
| Siliano, MR | 1 |
| Cruz, JW | 1 |
| Freichel, C | 1 |
| Kim, J | 1 |
| Sinn, DI | 1 |
| Lee, JJ | 1 |
| Kim, SU | 1 |
| Cui, XN | 1 |
| Chang, ML | 1 |
| Probst, A | 1 |
| Inaba, Y | 2 |
| Mollinari, C | 1 |
| Merlo, D | 1 |
| Morales, A | 1 |
| Bonnet, C | 1 |
| Bourgoin, N | 1 |
| Touvier, T | 1 |
| Nadam, J | 1 |
| Laglaine, A | 1 |
| Navarro, F | 1 |
| Moulin, C | 1 |
| Georges, B | 1 |
| Pequignot, JM | 1 |
| Bezin, L | 1 |
| Anderson, NJ | 1 |
| Slough, S | 1 |
| Watson, WP | 1 |
| Won, MH | 1 |
| Lee, HJ | 1 |
| Garrido Sanabria, ER | 1 |
| Castañeda, MT | 1 |
| Banuelos, C | 1 |
| Perez-Cordova, MG | 1 |
| Hernandez, S | 1 |
| Colom, LV | 1 |
| François, J | 2 |
| Zhou, JL | 2 |
| Frisch, C | 1 |
| Helmstaedter, C | 1 |
| Ang, CW | 1 |
| Carlson, GC | 1 |
| Coulter, DA | 4 |
| Ouazzani, R | 1 |
| Honda, Y | 1 |
| Kakuta, S | 1 |
| Sato, F | 1 |
| Kishi, K | 1 |
| Milh, M | 1 |
| Becq, H | 1 |
| Villeneuve, N | 1 |
| Aniksztejn, L | 1 |
| Jin, X | 1 |
| Huguenard, JR | 1 |
| Boehm, N | 1 |
| Engelhorn, T | 1 |
| Hufnagel, A | 1 |
| Weise, J | 1 |
| Baehr, M | 1 |
| Doerfler, A | 1 |
| Moffett, JR | 1 |
| Greene, ND | 1 |
| Bamidele, A | 1 |
| de Castro, SC | 1 |
| Wait, R | 1 |
| Leung, KY | 1 |
| Begum, S | 1 |
| Jensen, MS | 1 |
| Danscher, G | 1 |
| Barros, DO | 1 |
| Xavier, SM | 1 |
| Barbosa, CO | 1 |
| Silva, RF | 1 |
| Freitas, RL | 1 |
| Maia, FD | 1 |
| Takahashi, RN | 1 |
| Jay, TM | 1 |
| Schaub, C | 1 |
| Archie, M | 1 |
| Seo, DW | 1 |
| Gueler, N | 1 |
| Flor, PJ | 1 |
| van der Putten, H | 1 |
| Lin, H | 1 |
| Wu, LW | 1 |
| Chen, YC | 1 |
| Wen, XN | 1 |
| Betz, AJ | 1 |
| McLaughlin, PJ | 1 |
| Burgos, M | 1 |
| Weber, SM | 1 |
| Shetty, AK | 1 |
| Hattiangady, B | 1 |
| Bersudsky, Y | 2 |
| Bauer, M | 1 |
| Reitze, M | 1 |
| Oby, E | 1 |
| Batra, A | 1 |
| Uva, L | 1 |
| Hernandez, N | 1 |
| Van Boxel-Dezaire, A | 1 |
| Najm, I | 1 |
| Koka, K | 1 |
| Cole, AJ | 1 |
| Gomes, WA | 1 |
| Lado, FA | 1 |
| de Lanerolle, NC | 1 |
| Takahashi, K | 1 |
| Pan, C | 1 |
| Hetherington, HP | 1 |
| Wang, CA | 1 |
| Lui, CC | 1 |
| Yang, SN | 1 |
| Tiao, MM | 1 |
| Hsieh, CS | 1 |
| Lin, HH | 1 |
| Tsai, MC | 1 |
| Nakagawa, J | 1 |
| Miyamoto, J | 1 |
| André, V | 2 |
| El-Hassar, L | 1 |
| Ding, S | 1 |
| Fellin, T | 1 |
| Auberson, YP | 1 |
| Meaney, DF | 1 |
| Carmignoto, G | 1 |
| Haydon, PG | 2 |
| Gagliardi, B | 1 |
| Noé, F | 1 |
| Boer, K | 1 |
| Aronica, E | 1 |
| Martin, BS | 1 |
| Khan, FA | 1 |
| Jones, TD | 1 |
| Sheerin, AH | 1 |
| Miller, JW | 1 |
| D'Ambrosio, R | 1 |
| Khan, R | 1 |
| Sharma, AK | 1 |
| Reams, RY | 1 |
| Jordan, WH | 1 |
| Miller, MA | 1 |
| Thacker, HL | 1 |
| Snyder, PW | 1 |
| Terunuma, M | 1 |
| Vithlani, M | 1 |
| Sieghart, W | 1 |
| Kittler, J | 1 |
| Pangalos, M | 1 |
| Moss, SJ | 1 |
| Gupta, SK | 1 |
| Galpalli, ND | 1 |
| Srivastava, S | 1 |
| Agrawal, SS | 1 |
| Saxena, R | 1 |
| Tariq, M | 1 |
| Moutaery, KA | 1 |
| Deeb, SA | 1 |
| Feng, HJ | 1 |
| Mathews, GC | 1 |
| Kao, C | 1 |
| Ribak, CE | 2 |
| Savegnago, L | 1 |
| Rocha, JB | 1 |
| Shao, XG | 1 |
| Deng, YC | 1 |
| Hernandez, EF | 1 |
| Francisco, S | 1 |
| Willis, M | 1 |
| Zarei, M | 1 |
| Mikati, MA | 1 |
| Rizk, E | 1 |
| El Dada, S | 1 |
| Zeinieh, M | 1 |
| Kurdi, R | 1 |
| El Hokayem, J | 1 |
| Rahmeh, A | 1 |
| Koubeissi, M | 1 |
| Kobeissi, M | 1 |
| Azzam, D | 1 |
| Usta, J | 1 |
| El Sabban, M | 1 |
| Dbaibo, G | 1 |
| Hasson, H | 1 |
| Moshé, SL | 1 |
| Prado, VF | 1 |
| Prado, MA | 1 |
| Pereira, GS | 1 |
| Hellier, JL | 1 |
| Marin, JC | 1 |
| Moura, PJ | 1 |
| Xavier, GF | 1 |
| Zilbovicius, M | 1 |
| Mercadante, MT | 1 |
| Elwakkad, AS | 1 |
| El Elshamy, KA | 1 |
| Sibaii, H | 1 |
| Zhai, Y | 1 |
| Huo, XL | 1 |
| Zhang, JN | 1 |
| Moore, BJ | 1 |
| Henderson, SC | 1 |
| Campbell, JN | 1 |
| Lim, JS | 1 |
| Park, HK | 1 |
| Raghavendra, M | 1 |
| Morton, D | 1 |
| Parker, A | 1 |
| Estrada, P | 1 |
| Martinez, JR | 4 |
| McCurdy, RE | 1 |
| Martinez, R | 1 |
| Turski, WA | 2 |
| Mello, LM | 1 |
| Schwarz, M | 1 |
| Turski, L | 2 |
| Andermann, G | 1 |
| de Burlet, G | 1 |
| Cannet, C | 1 |
| Mawhinney, TP | 1 |
| Feather, MS | 1 |
| Barbero, GJ | 3 |
| Schmidt-Kastner, R | 1 |
| Olson, L | 1 |
| Okazaki, MM | 1 |
| Evenson, DA | 1 |
| Handforth, A | 1 |
| ten Berge, RE | 1 |
| Santing, RE | 1 |
| Hamstra, JJ | 1 |
| Roffel, AF | 1 |
| Zaagsma, J | 1 |
| Kofman, O | 1 |
| Vinnitsky, I | 1 |
| Alpert, C | 1 |
| Sofia, RD | 1 |
| Gordon, R | 1 |
| Gels, M | 1 |
| Diamantis, W | 1 |
| Bellíssimo, MI | 1 |
| Kulkarni, SK | 4 |
| George, B | 4 |
| Rice, A | 1 |
| Shapiro, SM | 1 |
| Jakoi, ER | 1 |
| Santos, NF | 3 |
| Martínez-Gomis, J | 1 |
| Planas, ME | 1 |
| Planelles, X | 1 |
| Bartrons, R | 1 |
| Sánchez, S | 1 |
| Thompson, K | 1 |
| Wasterlain, C | 1 |
| Schulman, SR | 1 |
| Canada, AT | 1 |
| Fryer, AD | 1 |
| Winsett, DW | 1 |
| Costa, DL | 1 |
| Simmons, ML | 1 |
| Terman, GW | 1 |
| Chavkin, C | 1 |
| Peredery, O | 1 |
| Bureau, YR | 1 |
| Cook, LL | 1 |
| Eder, HG | 1 |
| Stein, A | 1 |
| Fisher, RS | 1 |
| Mathur, R | 1 |
| Isokawa, M | 2 |
| Tada, E | 1 |
| Fike, JR | 1 |
| Tenório, F | 1 |
| Mendez-Otero, R | 1 |
| Belanger-Chellew, G | 1 |
| Amaral, OB | 1 |
| Rockenbach, IC | 1 |
| Roesler, R | 1 |
| Izquierdo, I | 1 |
| Martins, VR | 1 |
| Brentani, RR | 1 |
| Boyet, S | 2 |
| Marescaux, C | 3 |
| Karan, RS | 1 |
| Ravishankar, P | 1 |
| Pandhi, P | 1 |
| Smith, RL | 1 |
| Dal-Pizzol, F | 1 |
| Klamt, F | 1 |
| Vianna, MM | 1 |
| Schröder, N | 1 |
| Quevedo, J | 1 |
| Benfato, MS | 1 |
| Moreira, JC | 1 |
| Silva, JG | 1 |
| Marques, RH | 1 |
| Correia, L | 2 |
| Haugvicová, R | 2 |
| Kovacs, R | 2 |
| Eilers, A | 2 |
| Schulze, K | 2 |
| Lanksch, WR | 2 |
| Meencke, HJ | 1 |
| Cermak, JM | 1 |
| Tandon, P | 1 |
| Sarkisian, MR | 1 |
| Neill, JC | 1 |
| Blusztajn, JK | 1 |
| Mikulecká, A | 2 |
| Krsek, P | 2 |
| Hlinák, Z | 2 |
| Doherty, J | 1 |
| Zoukhri, D | 1 |
| Kublin, CL | 1 |
| Su, H | 2 |
| Lukasiuk, K | 1 |
| Jirmanová, I | 1 |
| Pal, S | 1 |
| Gil, D | 1 |
| Spalding, T | 1 |
| Kharlamb, A | 1 |
| Skjaerbaek, N | 1 |
| Uldam, A | 1 |
| WoldeMussie, E | 1 |
| Wheeler, L | 1 |
| Brann, M | 1 |
| Carvalho, RA | 1 |
| Sheets, D | 1 |
| Njunting, M | 1 |
| Wu, CL | 1 |
| Liou, CW | 1 |
| Wang, TJ | 1 |
| Tung, YR | 1 |
| Hsu, HY | 1 |
| Barbarosie, M | 1 |
| O'Connell, AC | 1 |
| Sollas, AL | 1 |
| Sakabe, S | 1 |
| Valente, SG | 1 |
| Pereira, M | 1 |
| Silva, I | 1 |
| Baracat, EC | 1 |
| Clarke, VR | 1 |
| Warre, R | 1 |
| Khan, GM | 1 |
| Ornstein, PL | 1 |
| Bleakman, D | 1 |
| Ogden, A | 1 |
| Weiss, B | 1 |
| Stables, JP | 1 |
| Ho, KH | 1 |
| Berkeley, JL | 1 |
| Decker, MJ | 1 |
| Levey, AI | 1 |
| Mejías-Aponte, CA | 1 |
| Jiménez-Rivera, CA | 1 |
| Segarra, AC | 1 |
| Varró, V | 1 |
| Vidal, RF | 1 |
| Dikstein, S | 1 |
| Adelstein, E | 1 |
| Quissel, D | 1 |
| Adshead, PC | 1 |
| Quissell, DO | 1 |
| Kotas, RV | 1 |
| Wells, TJ | 1 |
| Mims, LC | 1 |
| Trainor, EJ | 1 |
| Wiles, CL | 1 |
| Jope, RS | 1 |
| Kolasa, K | 1 |
| Song, L | 1 |
| Ormandy, GC | 1 |
| Peterson, CJ | 1 |
| Vinayak, S | 1 |
| Pazos, A | 1 |
| Gale, K | 1 |
| Smith, DL | 1 |
| Skuta, GL | 1 |
| Kincaid, MC | 1 |
| Rabbani, R | 1 |
| Cruess, DF | 1 |
| Kao, SF | 1 |
| Fisher, A | 1 |
| Brandeis, R | 1 |
| Karton, I | 1 |
| Pittel, Z | 1 |
| Gurwitz, D | 1 |
| Haring, R | 1 |
| Sapir, M | 1 |
| Levy, A | 1 |
| Heldman, E | 1 |
| Johnson, CJ | 1 |
| McCullough, LD | 1 |
| Steinpreis, RE | 1 |
| Gilbard, JP | 1 |
| Rossi, SR | 1 |
| Heyda, KG | 1 |
| Dartt, DA | 1 |
| Ikonomidou, C | 1 |
| Juniewicz, PE | 1 |
| Lemp, BM | 1 |
| Batzold, FH | 1 |
| Reel, JR | 1 |
| Wamil, A | 1 |
| Kleinrok, Z | 1 |
| Müller, RM | 2 |
| Roomans, GM | 3 |
| Stewart, BR | 1 |
| Rupniak, NM | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Scarlett, SM | 1 |
| Sagström, S | 1 |
| Sagulin, GB | 1 |
| Clifford, DB | 1 |
| Olney, JW | 1 |
| Maniotis, A | 1 |
| Collins, RC | 1 |
| Zorumski, CF | 1 |
| Gherezghiher, T | 1 |
| March, WF | 1 |
| Nordquist, RE | 1 |
| Koss, MC | 1 |
| Kuijpers, GA | 1 |
| Bardon, A | 1 |
| Ceder, O | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
| Hughes, BO | 1 |
| Spicer, B | 1 |
| Tokoro, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| Analysis of the Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome[NCT03711214] | 80 participants (Anticipated) | Interventional | 2018-12-01 | Active, not recruiting | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy[NCT00916266] | Phase 1 | 20 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Clinical and Genetic Factors Associated With Drug Resistance of Epilepsy[NCT04166305] | 180 participants (Anticipated) | Observational | 2019-11-01 | Recruiting | |||
| A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy[NCT01281956] | Phase 2 | 12 participants (Actual) | Interventional | 2011-01-07 | Terminated | ||
| Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease[NCT04650932] | 10 participants (Anticipated) | Interventional | 2022-10-22 | Recruiting | |||
| Impact of a Home-based Exercise Program on Prognostic Biomarkers in Men With Prostate Cancer[NCT03397030] | 27 participants (Actual) | Interventional | 2017-01-05 | Completed | |||
| Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Supplements as an Adjunct Therapy Before and After Photorefractive Keratectomy (PRK) Surgery[NCT01059019] | 17 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| Does Memantine Improve Verbal Memory Task Performance in Subjects With Localization-related Epilepsy and Memory Dysfunction? A Randomized, Double-Blind, Placebo-Controlled Trial[NCT01054599] | 29 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants were administered the Hamilton Anxiety Rating Scale (HAM-A) at the end of each three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. The HAM-A measures an individual's severity of anxiety symptoms. The scale consists of 14 parameters, each defined by a series of symptoms. Each group of symptoms is scored on a scale of 0 (not present) to 4 (severe), with a total score range of 0-56, where 30 severe anxiety. (NCT01281956)
Timeframe: Three months
| Intervention | score on a scale (Mean) |
|---|---|
| PRX-0023 | 5.1 |
| Placebo | 5.7 |
The Hamilton Depression Rating Scale (HAM-D) was administered to participants at the end of each treatment period. The HAM-D is a multiple item questionnaire used to provide an indication of depression. The questionnaire is designed for adults and is used to rate the severity of their depression by probing mood, feelings of guilt, suicide ideation, insomnia, agitation or retardation, anxiety, weight loss, and somatic symptoms. Although the HAM-D form lists 21 items, the scoring is based on the first 17 items. Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine items are scored from 0-2 with 0 = absent and 2 = frequent or severe. Scores range from 0 to 50 with a score of 0-7 representing normal and a score >/= 23 representing very severe depression. (NCT01281956)
Timeframe: Three months
| Intervention | score on a scale (Mean) |
|---|---|
| PRX-0023 | 5.3 |
| Placebo | 8.6 |
Participants used a seizure calendar to record the number of seizures that occurred during each three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. Seizure rate was calculated as the total number of seizures occurring during the three month period. The number of participants with >50% lower seizure frequency during the active compared with the placebo period was determined. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) |
|---|---|
| All Participants Who Completed Study | 0 |
An electrocardiogram was administered to participants at the end of each treatment period, i.e., at the end of the PRX-0023 and Placebo treatment periods. The number of abnormal ECG readings was noted in this measure. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) |
|---|---|
| PRX-0023 | 2 |
| Placebo | 3 |
Participants used a seizure calendar to record the number of seizures that occurred during the three month treatment period, i.e., while participants were either on PRX-0023 or Placebo. Seizure frequency was calculated as the total number of seizures occurring during each three month period. For each period a mean was calculated across subjects. (NCT01281956)
Timeframe: Three months
| Intervention | number of seizures (Mean) |
|---|---|
| PRX-0023 | 66.6 |
| Placebo | 54.3 |
The HVLT-R is a word-list learning and memory test.The participant is read a list of words and asked to recall as many as possible, without regard to the order in which they were read.The list is read three times with recall requested after each presentation (immediate recall) and after a delay (delayed recall). Individual test results are compared to others of the same age (+/-5 years).Test results are presented as T-scores which are conventionally used in neuropsychology. The participant's raw scores are compared to a population expected raw score, for a particular age group. That score is converted to a T-score.The interpretation of these T-scores is such that 50 is representative of the normal score in that age group in the general population. The standard deviation of these distributions are 10 units. Therefore, a score between 30-40 is considered mildly impaired, 20-30 is indicative of severe problems with learning and memory and a score of 60-70 indicates a very good memory. (NCT01281956)
Timeframe: Three months
| Intervention | psychometric T-score (Mean) | |
|---|---|---|
| Immediate Recall | Delayed Recall | |
| Placebo | 41.6 | 39.2 |
| PRX-0023 | 34.8 | 33.3 |
The number of subjects with abnormal clinical chemistry labs which is defined as a value outside of the NIH Clinical Center normal range. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| electrolyte abnormality | hyperglycemia | elevated liver function < 2 x normal | elevated liver function > 2 x normal | abnormal urinalysis | elevated uric acid | elevated BUN or Creatinine | |
| Placebo | 4 | 1 | 3 | 0 | 4 | 1 | 0 |
| PRX-0023 | 4 | 2 | 3 | 1 | 3 | 0 | 0 |
A Complete Blood Count (CBC) was administered at the end of each three month treatment period. A complete blood count test measures several components and features of your blood, including: Red blood cells (which carry oxygen), White blood cells (which fight infection), Hemoglobin (the oxygen-carrying protein in red blood cells), Hematocrit (the proportion of red blood cells to the fluid component (plasma) in your blood), Platelets, (which help with blood clotting). Abnormal increases or decreases in cell counts as revealed in a complete blood count may indicate an underlying medical condition, i.e., anemia (abnormal red blood cells, hemoglobin, and/or hematocrit), leucopenia (a decrease in white blood cells), leucocytosis (an increase in white blood cells), and thrombocytosis (an increase in platelets). Results were classified as either normal or abnormal. (NCT01281956)
Timeframe: Three months
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| anemia | leucopenia | leucocytosis | thrombocytosis | |
| Placebo | 1 | 1 | 3 | 2 |
| PRX-0023 | 2 | 2 | 2 | 0 |
The BVMT-R is a test of memory for visual information. Participants are shown a page with several geometric designs arranged in a 2x3 matrix and asked to study the designs. After the page is shown for a brief period the participant is asked to draw each figure.The same page is shown three times with recall requested after each presentation (immediate recall) and after a delay (delayed recall). Individual test results are compared to other people the same age (+/- 5 years).Test results are presented as T-scores which are conventionally used in neuropsychology. The participant's raw scores are compared to a population expected raw score, for a particular age group.That score is converted to a T-score.The interpretation of these T-scores is such that 50 is representative of the normal score in that age group in the general population.The standard deviation of these distributions are 10 units. A score of 30-40 is considered mildly impaired, 20-30 is indicative of severe problems (NCT01281956)
Timeframe: Three months
| Intervention | psychometric T-score (Mean) | |
|---|---|---|
| Immediate Recall | Delayed Recall | |
| Placebo | 39.0 | 37.4 |
| PRX-0023 | 37.4 | 38.0 |
SRT-CLTR (range 0-72; higher scores indicate better memory), and 7-24 Spatial Memory Test (range 0-35; scores are summed across the 5 learning trials, with higher scores indicating better memory) scores will be assessed across the first (baseline) and third (post-open label memantine) testing sessions. These measures are considered to be scores on a scale, rather than standard units. The hypothesis was that subjects randomized to memantine would demonstrate sustained improvement from baseline, while the placebo group would demonstrate improvements after taking open label memantine (compared to baseline). (NCT01054599)
Timeframe: 26 weeks
| Intervention | scores on a scale (Mean) | |||
|---|---|---|---|---|
| SRT CLTR Baseline | SRT CLTR Post-Open Label | 7-24 Total Learning Baseline | 7-24 Total Learning Post-Open Label | |
| Memantine | 32.67 | 40.33 | 30.33 | 31.67 |
| Sugar Pill | 22.71 | 40.29 | 28.14 | 32.43 |
Change scores from pre- to post-treatment/placebo were calculated for the primary outcome measures, the Selective Reminding Test Continuous Long-Term Retrieval (range 0-72; higher scores indicate better memory) and 7-24 Spatial Recall Test Total Learning (range 0-35; total correct across 5 learning trials are summed, with higher scores indicating better memory) scores. These measures are scores on a scale, rather than representing standard units. (NCT01054599)
Timeframe: 13 weeks
| Intervention | scores on a scale (Mean) | |
|---|---|---|
| 7-24 Spatial Recall Tests Learning Change Score | SRT Continuous Long-Term Retrieval Change Score | |
| Memantine | 1.00 | 4.38 |
| Sugar Pill | 1.78 | 8.11 |
20 reviews available for pilocarpine and Disease Models, Animal
| Article | Year |
|---|---|
The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023).
Topics: Animals; Disease Models, Animal; Electroencephalography; Models, Animal; Pilocarpine; Status Epilept | 2023 |
The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Pilocarpine; Rats; Rode | 2021 |
Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Physical Conditioning, Animal; Pilocarpine; Seizu | 2017 |
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Temporal Lobe; | 2014 |
Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kaini | 2016 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Chemically-induced TLE models: Topical application.
Topics: Administration, Topical; Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epile | 2016 |
The pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal L | 2008 |
The pilocarpine model of epilepsy: what have we learned?
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Exe | 2009 |
Cyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Mice; Neuronal | 2010 |
Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes; Penicillin G; Pentylenetetrazole; Pilocarp | 2010 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
Neuronal apoptosis after brief and prolonged seizures.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Dentate Gyrus; Disease Models, Animal; Kainic Acid; Neuro | 2002 |
Concise review: prospects of stem cell therapy for temporal lobe epilepsy.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Cell Differentiation; Disease Models, Animal; | 2007 |
Lithium-pilocarpine seizures as a model for lithium action in mania.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Inositol; Limbic System | 2007 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; | 2007 |
Lithium-pilocarpine neurotoxicity: a potential model of status epilepticus.
Topics: Animals; Disease Models, Animal; Lithium; Pilocarpine; Status Epilepticus | 1995 |
Recurrent seizures in the developing brain are harmful.
Topics: Adult; Animals; Brain; Brain Injuries; Child; Disease Models, Animal; Entorhinal Cortex; Epilepsy; H | 1997 |
Natural history and prevention of radiation injury.
Topics: Animals; Disease Models, Animal; Disease Progression; Free Radical Scavengers; Humans; Muscarinic Ag | 2000 |
Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy.
Topics: Animals; Brain; Cholinergic Fibers; Disease Models, Animal; Mice; Pilocarpine; Rats; Seizures | 1989 |
1 trial available for pilocarpine and Disease Models, Animal
| Article | Year |
|---|---|
Two decades of research towards a potential first anti-epileptic drug.
Topics: Animals; Disease Models, Animal; Humans; Pharmaceutical Preparations; Pilocarpine; Seizures; Status | 2021 |
1092 other studies available for pilocarpine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Biomarkers; Datasets as Topic; Disease Models, Animal; Drug Discovery; Epi | 2021 |
Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy; E | 2021 |
In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; | 2021 |
Proteins related to ictogenesis and seizure clustering in chronic epilepsy.
Topics: Animals; Cerebral Cortex; Cluster Analysis; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mic | 2021 |
Increased expression of Rho-associated protein kinase 2 confers astroglial Stat3 pathway activation during epileptogenesis.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilocarpi | 2022 |
Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Epilepsy; Hippocampus | 2021 |
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Male; Mice; Pilocarpine; Seizures; | 2021 |
Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cymbopogon; Disease Models, Animal; Dose-Res | 2022 |
Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Long-Term Potentiati | 2021 |
MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; Neurons; Ne | 2022 |
Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; | 2023 |
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures | 2022 |
Mechanism for Altered Dark-Adapted Electroretinogram Responses in DBA/2J Mice Includes Pupil Dilation Deficits.
Topics: Animals; Disease Models, Animal; Electroretinography; Glaucoma; Glaucoma, Open-Angle; Intraocular Pr | 2022 |
Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kina | 2022 |
The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/
Topics: Animals; Apoptosis; beta Catenin; Computational Biology; Disease Models, Animal; Down-Regulation; Ep | 2022 |
Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.
Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Pilocarp | 2022 |
Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Group IV Phospholipases A2; Hipp | 2022 |
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Generalized; Hippocampus; Pilocarpin | 2022 |
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Glycogen; Mice; Pilocarp | 2022 |
Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mammals; Mice; Mossy Fibers, | 2022 |
Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; P | 2022 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation | 2022 |
Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromatography, Liquid; Disease Models, | 2022 |
Regulation of Inflammation-Related Genes through
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Levetiracetam; Mice; Piloc | 2022 |
Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Topics: Animals; Anticonvulsants; Cytokines; Disease Models, Animal; Encephalitis; Levetiracetam; Mice; Mono | 2022 |
Negative effects of brain regulatory T cells depletion on epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilo | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interl | 2022 |
Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Huma | 2022 |
Effect of morphine administration after status epilepticus on epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Lithium; Morphine; Naloxone; Pilocarpine; Rats; Seizures; | 2022 |
Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Galectin 1; Hippocampus; Neuroprotective A | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.
Topics: Animals; Disease Models, Animal; Endurance Training; Epilepsy; Hippocampus; Humans; Pilocarpine; Rat | 2022 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Optogenetics; Pilocarpine; Rats; Rats, Spr | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hippocampus; Iridoids; Mice; Pilocarpine; Rats; R | 2023 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Upregulation of SLITRK5 in patients with epilepsy and in a rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Neocortex; Pilocarp | 2023 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System.
Topics: Animals; Cytokines; Disease Models, Animal; Endocannabinoids; Hippocampus; Interleukin-6; Lithium; N | 2023 |
Optogenetic activation of septal inhibitory cells abates focal seizures.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Optogenetics; Parvalbum | 2023 |
Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Pilocarpin | 2023 |
Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mo | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufen | 2023 |
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Larva; Pentylenetetrazole; | 2023 |
GL-II-73, a Positive Allosteric Modulator of α5GABA
Topics: Animals; Disease Models, Animal; Dopamine; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Qualit | 2023 |
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe | 2023 |
Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2023 |
Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE).
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium; Neocortex; Pilocarpine; Rats; Status Epilepti | 2023 |
Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2023 |
EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications.
Topics: Animals; Disease Models, Animal; Epilepsy; Genetic Therapy; Hippocampus; Mice; Neurons; Pilocarpine; | 2023 |
Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Humans; Interleukin-6; Mice; Mi | 2023 |
Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin | 2023 |
Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mefloquine; Neuropr | 2023 |
Upregulated SHP-2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model.
Topics: Adolescent; Adult; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fem | 2020 |
Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model.
Topics: Animals; Disease Models, Animal; Evidence-Based Practice; Hippocampus; Pilocarpine; Rats; Rats, Spra | 2019 |
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy.
Topics: Adenoviridae; Analysis of Variance; Animals; Apoptosis; Brain; Disease Models, Animal; Epilepsy; Hip | 2019 |
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus.
Topics: Animals; Anticoagulants; Disease Models, Animal; Hippocampus; Male; Mice; Pilocarpine; Pyrroles; Qui | 2019 |
Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; | 2020 |
Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Hippocampus; Mice; Neurogenesis; Pilocarpine; Status | 2021 |
Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Mitochondria; Mitophagy; | 2020 |
The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.
Topics: Animals; Catalase; Disease Models, Animal; Histamine H3 Antagonists; Male; Neuroprotective Agents; P | 2019 |
Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Chemokine CCL2; Disease Models, Animal; Epilepsy; Male; Microglia; | 2020 |
Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus.
Topics: Animals; Astrocytes; Disease Models, Animal; Hippocampus; Interferons; Male; Mice, Inbred C57BL; Mic | 2020 |
Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Brain Waves; Connectome; Disease Models, Animal; Electrocorticography; Epilepsy, Temporal L | 2020 |
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Topics: Animals; Antibodies; Apoptosis; Autophagy; Disease Models, Animal; Epilepsy; Hippocampus; HMGB1 Prot | 2020 |
The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Neur | 2020 |
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Male; M | 2020 |
Neuroprotective effects of thromboxane receptor antagonist SQ 29,548 after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; | 2020 |
Effects of Non-invasive, Targeted, Neuronal Lesions on Seizures in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Feasibility Studies; | 2020 |
The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Polarity; Disease Models, Animal; Ependymoglial Cells; Mice; Neural Stem Cells; Neurog | 2020 |
Propofol inhibited apoptosis of hippocampal neurons in status epilepticus through miR-15a-5p/NR2B/ERK1/2 pathway.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Down-Regulati | 2020 |
Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; GABAergic Neurons; Glutamate Decarboxylase | 2020 |
Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; G | 2020 |
Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus.
Topics: Animals; Dendrites; Disease Models, Animal; Interneurons; Male; Neurons; Olfactory Bulb; Parvalbumin | 2020 |
TRPV1 Contributes to the Neuroprotective Effect of Dexmedetomidine in Pilocarpine-Induced Status Epilepticus Juvenile Rats.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Dexmedetomidine; Disease Models, Animal; Male; Membrane Pote | 2020 |
CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage.
Topics: Animals; Apoptosis; Brain; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Disea | 2019 |
Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.
Topics: Animals; Antagomirs; Apoptosis; Cell Death; Disease Models, Animal; Down-Regulation; Male; Mice, Inb | 2020 |
Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons.
Topics: Animals; Anticonvulsants; Autophagosomes; Autophagy; Autophagy-Related Proteins; Behavior, Animal; D | 2020 |
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal L | 2020 |
Withanolide-A treatment exerts a neuroprotective effect via inhibiting neuroinflammation in the hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Neuroprotection; Neuroprotec | 2020 |
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice.
Topics: Animals; Disease Models, Animal; Epilepsy; Male; Memory; Mice; Muscarinic Agonists; Pilocarpine | 2020 |
Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; High-Throughput | 2020 |
Loss of Protection by Antiepileptic Drugs in Lipopolysaccharide-primed Pilocarpine-induced Status Epilepticus is Mediated via Inflammatory Signalling.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pil | 2020 |
Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Lipopolysaccharides; Locomotion; Male; Mice; | 2020 |
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Topics: Animals; Anticonvulsants; Azoles; Brain; Calcium Signaling; CHO Cells; Cricetulus; Disease Models, A | 2020 |
Effects of Dexamethasone on Remodeling of the Hippocampal Synaptic Filamentous Actin Cytoskeleton in a Model of Pilocarpine-induced Status Epilepticus.
Topics: Actin Cytoskeleton; Actins; Animals; Dexamethasone; Disease Models, Animal; Hippocampus; Humans; Mic | 2020 |
Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy.
Topics: Animals; Behavior, Animal; Cognition; Cytokines; Disease Models, Animal; Epilepsy; Hippocampus; Infl | 2020 |
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Circulating MicroRNA; Disease Models, Animal; Electri | 2020 |
The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Boron Compounds; Cymenes; Disease Models, Animal | 2020 |
The efficacy of fructose-1,6-bisphosphate in suppressing status epilepticus in developing rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Fructose; Hippocampus; Pil | 2020 |
Iris stromal cell nuclei deform to more elongated shapes during pharmacologically-induced miosis and mydriasis.
Topics: Animals; Disease Models, Animal; Drug Combinations; Iris; Microscopy, Confocal; Miosis; Miotics; Myd | 2021 |
Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Blood Glucose; Disease Models, Animal; Drug Resistant Epilepsy; Female; Hi | 2020 |
Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Brain; Disease Models, Animal; Drug Therapy, | 2020 |
Deciphering key regulators involved in epilepsy-induced cardiac damage through whole transcriptome and proteome analysis in a rat model.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Epilepsy; Gene Expression Profiling; Gene R | 2021 |
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Susceptibility; Gene Expression; | 2021 |
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Topics: Animals; Anticonvulsants; Benzyl Alcohols; Disease Models, Animal; Electroencephalography; Epilepsy, | 2021 |
The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2020 |
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Me | 2021 |
Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons.
Topics: Animals; Anticonvulsants; Cytoskeletal Proteins; Disease Models, Animal; Drugs, Chinese Herbal; Epil | 2021 |
Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy.
Topics: Adamantane; Animals; Anticonvulsants; CA1 Region, Hippocampal; Calcium; Dibenzazepines; Disease Mode | 2021 |
Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Ep | 2021 |
Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Cell Surv | 2021 |
Alkaline brain pH shift in rodent lithium-pilocarpine model of epilepsy with chronic seizures.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Drug Resistant Epilepsy; Epile | 2021 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model.
Topics: Adenylate Kinase; Animals; Behavior, Animal; Benzyl Alcohols; Brain-Derived Neurotrophic Factor; Dis | 2021 |
Citral Effects on the Expression Profile of
Topics: Acyclic Monoterpenes; Animals; Brain-Derived Neurotrophic Factor; Cytokines; Disease Models, Animal; | 2021 |
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept | 2021 |
Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network.
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Cyclic ADP-Ribose; Disease Models, Animal; Electrophoresis; E | 2021 |
Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Behavior, Animal; D | 2021 |
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop | 2021 |
Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model.
Topics: Acupuncture Therapy; Animals; Bee Venoms; Cytokines; Disease Models, Animal; Pilocarpine | 2021 |
Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lutein; Neuroprotective Agents; | 2021 |
Limbic progesterone receptor activity enhances neuronal excitability and seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Neurons; Pilocarpine; Progesterone; | 2021 |
Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Fructose; Fructosediphosphates; Glucose; | 2021 |
The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Epilepsy, Tempor | 2017 |
Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Cells, Cultured; Child; Diazepam; Disease Models, Animal; Enzyme Inhibitor | 2016 |
Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cognition Disorders; Disease Models, Animal; Gene | 2017 |
Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy.
Topics: Anesthetics; Animals; Brain; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, | 2017 |
Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Doublecortin Domain P | 2017 |
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport P | 2017 |
Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice.
Topics: Animals; Bromodeoxyuridine; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Female | 2017 |
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Astrocytes; Disease Models, Animal; Drug Therapy, Combi | 2017 |
Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.
Topics: Adolescent; Adult; Animals; B-Cell Activating Factor; B-Cell Activation Factor Receptor; Blotting, W | 2017 |
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Nerve De | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra | 2017 |
Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices.
Topics: Animals; Anticonvulsants; Atropine; Corticosterone; Diazepam; Disease Models, Animal; Electric Stimu | 2017 |
Neurosteroid-sensitive δ-GABA
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Down-Regulat | 2017 |
Simultaneous triple therapy for the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Respo | 2017 |
Rabies tracing of birthdated dentate granule cells in rat temporal lobe epilepsy.
Topics: Age Factors; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Disease Model | 2017 |
Involvement of microRNA-146a in the Inflammatory Response of S tatus Epilepticus Rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Cytokines; Disease Models, Animal; Gene Expression Regulati | 2017 |
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation.
Topics: Animals; Butadienes; Disease Models, Animal; Dynamins; Enzyme Inhibitors; Male; Mitochondria; Mitoch | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; D | 2017 |
Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model.
Topics: Animals; Astrocytes; Autoradiography; Brain; Carbazoles; Carrier Proteins; Disease Models, Animal; E | 2017 |
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anticonvulsants; Apoptosis; Blood-Brain B | 2017 |
The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Flavonoids; GAP-43 Protein; Male; Mitogen-Activated Prote | 2017 |
Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Circadian Rhythm; Cluster Analysis; Disease Models, Animal; Electroencepha | 2017 |
A systems level analysis of epileptogenesis-associated proteome alterations.
Topics: Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Female; Gene Regulatory Networks; Mu | 2017 |
Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2 | 2017 |
Inherent vulnerabilities in monoaminergic pathways predict the emergence of depressive impairments in an animal model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Convulsants; Depression; Disease Models, Animal; Epil | 2017 |
Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus.
Topics: Animals; Antigens, Nuclear; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Doublecor | 2017 |
Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus.
Topics: Action Potentials; Animals; Disease Models, Animal; Hippocampus; Male; Neuronal Plasticity; Neurons; | 2017 |
Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Lamotrigi | 2017 |
The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Disease Models, Animal; Drug R | 2017 |
Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electrocorticography; Entorhinal | 2017 |
SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Dual-Specificity Phosphatases; Epilepsy; Gene Expression Regulation | 2017 |
Altered intrinsic functional connectivity in the latent period of epileptogenesis in a temporal lobe epilepsy model.
Topics: Animals; Brain Mapping; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Tempo | 2017 |
Dynamic regulation effect of long non-coding RNA-UCA1 on NF-kB in hippocampus of epilepsy rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Disease Progression; Epilepsy; Gene Expression Re | 2017 |
Effects of acute physical exercise in the light phase of sleep in rats with temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrocorticography; Electrodes, Implanted; Epilepsy, Tempo | 2017 |
Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.
Topics: Animals; Cell Differentiation; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Exp | 2017 |
Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Mal | 2017 |
Effect of diet with omega-3 in basal brain electrical activity and during status epilepticus in rats.
Topics: Animals; Brain; Cell Death; Dietary Supplements; Disease Models, Animal; Electrocorticography; Elect | 2017 |
An alkaloid extract obtained from Phlegmariurus Saururus induces neuroprotection after status epilepticus.
Topics: Animals; Apoptosis; Astrocytes; Cell Death; Cells, Cultured; Coculture Techniques; Disease Models, A | 2017 |
Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Disease Models, Animal; Epilepsy, Tempora | 2018 |
Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epileps | 2017 |
[Expression and spatial distribution of P2X7 receptor in pilocarpine-induced epileptic rat hippocampus].
Topics: Animals; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Hippocampus; Pilocarpine; Rat | 2017 |
DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Antioxidants; Diazepam; Disease Models, Animal; DNA Damage; Hi | 2018 |
Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Metformin; Pilocarp | 2018 |
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
Topics: Analysis of Variance; Animals; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 5; Hippocam | 2017 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administrati | 2017 |
Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus.
Topics: Animals; Antagomirs; Disease Models, Animal; Hippocampus; Inflammation; Lithium Compounds; Male; Mic | 2018 |
Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cerebral Cortex; Cognition Disorders; Convulsants; | 2018 |
Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity.
Topics: Alopecia; Animals; Biophysics; Body Weight; Bronchoconstrictor Agents; Cell Line, Transformed; Disea | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression.
Topics: Animals; Disease Models, Animal; Disease Progression; Electroencephalography; Female; Hippocampus; M | 2017 |
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP | 2018 |
Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Waves; Cerebral Cortex; Disease Model | 2018 |
The effects of calcineurin inhibitor FK506 on actin cytoskeleton, neuronal survival and glial reactions after pilocarpine-induced status epilepticus in mice.
Topics: Actin Cytoskeleton; Actins; Animals; Anticonvulsants; Calcineurin Inhibitors; Calcium-Binding Protei | 2018 |
Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Topics: Animals; Apoptosis; Disease Models, Animal; Ectopic Gene Expression; Epilepsy; Hippocampus; Male; Mi | 2018 |
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cycloox | 2018 |
Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; Muscarinic Agonists; Pilocarpine; Rat | 2018 |
Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia.
Topics: Animals; Axon Initial Segment; Axons; Disease Models, Animal; Disease Susceptibility; Electroencepha | 2018 |
New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy.
Topics: Animals; Caspase 3; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intrav | 2018 |
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus.
Topics: Animals; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hippocampus; I | 2018 |
Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis.
Topics: Animals; Atorvastatin; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Female; Male; M | 2018 |
Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat | 2018 |
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cytokines; Dexamethasone; Dinoprostone; Disease Mode | 2018 |
Na
Topics: Animals; Antibodies; Anticonvulsants; Caspase 3; Disease Models, Animal; Drug Evaluation, Preclinica | 2018 |
Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Doublec | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Blood Glucose; Convulsants; Cytokines | 2018 |
The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2018 |
Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Mi | 2018 |
Neuroprotective effect of curcumin nanoparticles against rat model of status epilepticus induced by pilocarpine.
Topics: Animals; Antioxidants; Curcuma; Curcumin; Disease Models, Animal; Lipid Peroxidation; Male; Nanopart | 2018 |
Folate homeostasis in epileptic rats.
Topics: Animals; Brain; CD11b Antigen; Convulsants; Disease Models, Animal; Folate Receptor 1; Folic Acid; G | 2018 |
Status epilepticus: Role for etiology in determining response to benzodiazepines.
Topics: Animals; Benzodiazepines; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; | 2018 |
Acute Changes in Electrophysiological Properties of Cortical Regular-Spiking Cells Following Seizures in a Rat Lithium-Pilocarpine Model.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Lithium Compounds; Membrane Potentials; Models, | 2018 |
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Topics: 4-Aminopyridine; Adolescent; Adult; Animals; Brain; Carbazoles; Child; Cyclic GMP; Cyclic GMP-Depend | 2018 |
A novel online fluorescence method for in-vivo measurement of hydrogen peroxide during oxidative stress produced in a temporal lobe epilepsy model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hydrogen Peroxide; | 2018 |
Different behavioral and pathological changes between epilepsy-associated depression and primary depression models.
Topics: Animals; Depression; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Male; Pilocarp | 2018 |
Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
Topics: Animals; Behavior, Animal; Cation Transport Proteins; Cerebral Cortex; Disease Models, Animal; Femal | 2019 |
Dysregulated long non-coding RNAs in the temporal lobe epilepsy mouse model.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling | 2018 |
Immunotherapy by targeting of VGKC complex for seizure control and prevention of cognitive impairment in a mouse model of epilepsy.
Topics: Animals; Antibodies; Cognitive Dysfunction; Disease Models, Animal; Humans; Immunotherapy; Lithium; | 2018 |
Effect of prenatal stress on ɑ5 GABA
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Gene Expression Regulation, Developmental | 2018 |
Altered activity and information flow in the default mode network of pilocarpine-induced epilepsy rats.
Topics: Animals; Brain; Brain Waves; Connectome; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2018 |
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Cognition Disorders; Depressive Disorder; Disease Mode | 2018 |
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combi | 2019 |
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspa | 2018 |
The effect of dichloroacetate in mouse models of epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Dichloroacetic Acid; Disease Models, An | 2018 |
Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Interpersonal Relations; Mental Disorders; Piloca | 2018 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; | 2019 |
Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Beha | 2018 |
Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.
Topics: Adult; Analysis of Variance; Animals; Anticonvulsants; Biophysics; Cells, Cultured; Dentate Gyrus; D | 2018 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Enzyme Inhibitors; Humans; | 2018 |
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hepatocyte Growth Factor; Hippocampus; I | 2018 |
Abnormal hippocampal functional network and related memory impairment in pilocarpine-treated rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Hippocampus; Image P | 2018 |
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Calcium-Binding Proteins; Cyclooxygen | 2018 |
Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α.
Topics: Animals; Anti-Inflammatory Agents; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Epileps | 2018 |
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.
Topics: Animals; Apoptosis; Cell Polarity; Cytokines; Disease Models, Animal; Female; Gene Expression Regula | 2018 |
Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [
Topics: Acholeplasmataceae; Animals; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Fluorodeoxygl | 2018 |
Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis.
Topics: Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Female; Gene Exp | 2018 |
Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epile | 2018 |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Drug Discovery; Epilepsy; Epi | 2018 |
Alterations in mRNA expression of glutamate receptor subunits and excitatory amino acid transporters following pilocarpine-induced seizures in rats.
Topics: Animals; Disease Models, Animal; Hippocampus; Male; Pilocarpine; Rats, Wistar; Receptors, AMPA; Rece | 2018 |
Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hippocampus; Levetiracetam; Lith | 2018 |
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent K
Topics: Administration, Oral; Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease M | 2018 |
[Targeting diagnosis and treatment value of chelating anti-IL-1β mAb-SPIONs in temporal lobe epilepsy model].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; Pilocarpin | 2018 |
Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats?
Topics: Animals; Brain; Cholesterol; Diet, High-Fat; Disease Models, Animal; Electroencephalography; Male; P | 2019 |
The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures.
Topics: Action Potentials; Animals; Cell Differentiation; Cell Line; Disease Models, Animal; Glatiramer Acet | 2018 |
Chemical biomarkers of epileptogenesis and ictogenesis in experimental epilepsy.
Topics: Animals; Biomarkers; Brain; Convulsants; Disease Models, Animal; Extracellular Space; Male; Pilocarp | 2019 |
The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Disease Models, Animal; Hippocampus; Male; Necrosis; Neurons; Pilocarpine; Rando | 2018 |
Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model.
Topics: Animals; Disease Models, Animal; Gene Expression; Hippocampus; Lithium Chloride; Male; Membrane Glyc | 2018 |
Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Epilepsy; Hippocamp | 2018 |
Biochemical Changes Indicate Developmental Stage in the Hippocampal Formation.
Topics: Age Factors; Animals; Brain; Creatine; Disease Models, Animal; Hippocampus; Male; Pilocarpine; Rats, | 2019 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2019 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Glycyrrhizic Acid; Hippocampus; HMG | 2019 |
Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; GABA-B Receptor Antagon | 2019 |
Coronary vasodilation impairment in pilocarpine model of epilepsy.
Topics: Animals; Coronary Artery Disease; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonists; Piloc | 2019 |
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem | 2019 |
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cannabidiol; Disease Models, Animal; Epilepsy; Epilepsy, | 2019 |
Catalpol Exerts an Anti-Epilepticus Effect, Possibly by Regulating the Nrf2-Keap1-ARE Signaling Pathway.
Topics: Animals; China; Disease Models, Animal; Epilepsy; Iridoid Glucosides; Kelch-Like ECH-Associated Prot | 2018 |
The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Biomarkers; Convulsants; Disease Models, Animal; Hipp | 2019 |
Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model.
Topics: Animals; Anticonvulsants; Benzoxazines; Disease Models, Animal; Endocannabinoids; Hippocampus; Lithi | 2019 |
Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Iridoid Glucosides; Lithium; Mal | 2019 |
Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cholinergic Agonists; Disease Models, Ani | 2019 |
[Efficacy of brain-targeted rapamycin for treatment of epilepsy in rats].
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; | 2018 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Comorbidity; Depressive Disorder; Disease | 2019 |
The Neuroprotective Effect of
Topics: Animals; Basidiomycota; Cell Death; Disease Models, Animal; Hippocampus; Humans; Mice; Neurons; Neur | 2019 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Tempor | 2019 |
(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.
Topics: Animals; Catechin; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; | 2019 |
Increased expression of DOC2A in human and rat temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Calcium-Binding Proteins; Disease Models, Animal; Epilepsy, Temporal Lob | 2019 |
Anticonvulsant and Neuroprotective Effects of Dexmedetomidine on Pilocarpine-Induced Status Epilepticus in Rats Using a Metabolomics Approach.
Topics: Animals; Anticonvulsants; Brain; Chromatography, Liquid; Dexmedetomidine; Disease Models, Animal; Hi | 2019 |
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe | 2019 |
Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice.
Topics: Animals; Anxiety; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; GABAergic Neur | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2019 |
Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Methylazoxymethanol Acetate; | 2019 |
ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY.
Topics: Adenosine A1 Receptor Agonists; Animals; Apoptosis; Disease Models, Animal; Epilepsy; Hippocampus; L | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; | 2019 |
The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Glucagon-Like Peptide-1 Receptor; Male; Neuroprotective A | 2019 |
Neuroprotective effects of lovastatin in the pilocarpine rat model of epilepsy according to the expression of neurotrophic factors.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Ciliary Neurotrophic Factor; Disease Models, | 2019 |
Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.
Topics: Animals; Boron Compounds; Disease Models, Animal; Drug Delivery Systems; Epilepsy, Temporal Lobe; Fl | 2019 |
Ameliorating impacts of ginseng on the apoptosis of spermatogenic cells and sperm quality in temporal lobe epilepsy rat model treated with valproate.
Topics: Animals; Anticonvulsants; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Infert | 2019 |
Upregulation of hippocampal synaptophysin, GFAP and mGluR3 in a pilocarpine rat model of epilepsy with history of prolonged febrile seizure.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Prote | 2019 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
Targeting Seizure-Induced Neurogenesis in a Clinically Relevant Time Period Leads to Transient But Not Persistent Seizure Reduction.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Neural Stem Cells; Neu | 2019 |
Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model.
Topics: Animals; Disease Models, Animal; Epilepsy; GluK2 Kainate Receptor; Hippocampus; Muscarinic Agonists; | 2019 |
Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management.
Topics: Animals; Disease Models, Animal; Epilepsy; Fibrosis; Heart Diseases; Lithium Compounds; Male; Myocar | 2019 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Mapping; Calcium-Binding Proteins; Complement C3; Diffusion Magnetic Resonance | 2014 |
The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Death; Diazepam; Disease Models, Animal; Drug Therapy, Combination; | 2013 |
Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a study on patients and pilocarpine-induced rats.
Topics: Animals; Astrocytes; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; | 2013 |
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.
Topics: Animals; Dendrites; Dendritic Spines; Disease Models, Animal; Electroencephalography; Gliosis; Hippo | 2013 |
Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation.
Topics: Amidohydrolases; Analysis of Variance; Angiotensin-Converting Enzyme 2; Animals; Catalase; Disease M | 2013 |
Investigation of capsaicin-induced superficial punctate keratopathy model due to reduced tear secretion in rats.
Topics: Animals; Capsaicin; Corneal Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Dry | 2013 |
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.
Topics: Animals; Behavioral Symptoms; Biomarkers; Bipolar Disorder; Calbindin 2; Dentate Gyrus; Disease Mode | 2013 |
Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Epilepsy; Fatty Acids, Omega-3; Heart Rate; Mu | 2013 |
Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism.
Topics: Adenosine A2 Receptor Antagonists; Animals; Deep Brain Stimulation; Disease Models, Animal; Dopamine | 2013 |
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; C | 2013 |
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice.
Topics: Amino Acids; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy, | 2013 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Brain; Carbamates; Cell Count; Dis | 2013 |
Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy.
Topics: Animals; Dependovirus; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glutathione Tra | 2013 |
Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure.
Topics: Animals; Disease Models, Animal; Epilepsy, Generalized; Male; Muscarinic Agonists; Neurons; Pilocarp | 2013 |
Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity.
Topics: Animals; Calbindin 2; Carrier Proteins; Cation Transport Proteins; Cell Count; Dendrites; Disease Mo | 2013 |
Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation.
Topics: Animals; Blotting, Western; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, T | 2013 |
Pregabalin attenuates excitotoxicity in diabetes.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Blood Glucose; Cell Line; Diabetic Neuropathies; D | 2013 |
Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cells, Cultured; Claudin-5; Disease Models, An | 2013 |
Speed modulation of hippocampal theta frequency correlates with spatial memory performance.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2013 |
High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Mossy Fibers, H | 2013 |
Anticonvulsant screening of luteolin in four mouse seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2013 |
Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy.
Topics: Animals; Behavior, Animal; Brain Mapping; Creatine; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2013 |
Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Deep Brain Stimulation; Diazepam; Diseas | 2013 |
Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Dentate Gyrus; Disease Models, Animal; Granulins; Hippocampus; Intercellular Si | 2013 |
Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Hippocampus; Lithium; Nerve Degeneration; Piloc | 2013 |
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Cannabinoids; Cannabis; Disease Models, Animal; Dose-R | 2013 |
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonis | 2013 |
Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.
Topics: Allosteric Regulation; Animals; Binding Sites; Cognition Disorders; D-Amino-Acid Oxidase; Disease Mo | 2013 |
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.
Topics: Animals; Depression; Disease Models, Animal; Disease Susceptibility; Epilepsy; Galanin; Gene Express | 2013 |
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Dipeptides; Disease Models, Animal; Electric Stimulation; Epil | 2013 |
Validation of suitable reference genes for expression studies in different pilocarpine-induced models of mesial temporal lobe epilepsy.
Topics: Animals; Computational Biology; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Reg | 2013 |
The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.
Topics: Animals; Brain; Cell Death; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Hippocamp | 2014 |
STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.
Topics: Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Aci | 2013 |
Elevated expression of pleiotrophin in pilocarpine-induced seizures of immature rats and in pentylenetetrazole-induced hippocampal astrocytes in vitro.
Topics: Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytokines; | 2014 |
Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Fe | 2013 |
Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup.
Topics: Age Factors; Animals; Animals, Newborn; Chi-Square Distribution; Convulsants; Disease Models, Animal | 2014 |
Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cerebral Cortex; Citric Acid Cycle; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mi | 2014 |
Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavioral Symptoms; Brain; Chronic Disease; | 2014 |
Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.
Topics: Animals; Animals, Newborn; Caspase 3; Cells, Cultured; Choline O-Acetyltransferase; Disease Models, | 2014 |
Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries; Cerebral Cortex; Dexamethasone; Dise | 2014 |
Changes of salivary functions in experimental periodontitis model rats.
Topics: Acinar Cells; Animals; Apoptosis; Blotting, Western; Calcium; Disease Models, Animal; Ligation; Male | 2014 |
[Rapamycin improves learning and memory ability in ICR mice with pilocarpine-induced temporal lobe epilepsy].
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy; Learning; Memory; Mice; Mice, Inbred ICR; Neu | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetra | 2013 |
Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Analysis of Variance; Animals; Disease Mo | 2014 |
Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Resistance; Electroencephal | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice.
Topics: Animals; Disease Models, Animal; Down-Regulation; Female; Hippocampus; Immunohistochemistry; Interne | 2014 |
The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Frontal Lobe; Gene Expression Regulation; Mal | 2014 |
Pilocarpine-induced epilepsy is associated with actin cytoskeleton reorganization in the mossy fiber-CA3 synapses.
Topics: Actins; Animals; Cytoskeleton; Disease Models, Animal; Disks Large Homolog 4 Protein; Epilepsy; Gene | 2014 |
Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chronic Disease; Disease Models, A | 2014 |
Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT.
Topics: Animals; Aqueous Humor; Ciliary Body; Disease Models, Animal; Intraocular Pressure; Mice; Muscarinic | 2014 |
In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease Models, Animal; Epileps | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Attention and executive functions in a rat model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Attention; Brain; Brain Mapping; Carbamates; Cell Count; Disease Models, A | 2014 |
NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus.
Topics: Animals; CA3 Region, Hippocampal; Capillaries; Carrier Proteins; Dentate Gyrus; Disease Models, Anim | 2014 |
Melatonin protects testes against lithium-pilocarpine-induced temporal lobe epilepsy in rats: a time course study.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Male; Melatonin; Piloc | 2015 |
Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE).
Topics: Adult; Animals; Anterior Temporal Lobectomy; Disease Models, Animal; Epilepsy, Temporal Lobe; Female | 2014 |
Pre-control characterization of hippocampal epileptic models.
Topics: Algorithms; Animals; Disease Models, Animal; Electrodes, Implanted; Hippocampus; Kindling, Neurologi | 2014 |
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocam | 2014 |
Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Cognition Disorders; Comorbidity; Disease Model | 2014 |
Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Electroencephal | 2014 |
The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice.
Topics: Animals; Aqueous Humor; Ciliary Body; Disease Models, Animal; Glaucoma; Imaging, Three-Dimensional; | 2014 |
Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Exploratory Behavior; Kainic Acid; Male; Maze Learning; Memory, Sho | 2014 |
Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy.
Topics: Animals; Anticholesteremic Agents; Cytokines; Disease Models, Animal; Epilepsy; Gene Expression Regu | 2014 |
Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus.
Topics: Animals; Dendritic Spines; Disease Models, Animal; Electroencephalography; Gene Expression Regulatio | 2015 |
Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; CD11b Antigen; Cell Count; Chronic Disease; | 2015 |
Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.
Topics: Animals; Calcium Channels; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Molec | 2015 |
Reorganization of supramammillary-hippocampal pathways in the rat pilocarpine model of temporal lobe epilepsy: evidence for axon terminal sprouting.
Topics: Animals; Biotin; Dextrans; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Hypothalamu | 2015 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Temporally unstructured electrical stimulation to the amygdala suppresses behavioral chronic seizures of the pilocarpine animal model.
Topics: Amygdala; Animals; Deep Brain Stimulation; Disease Models, Animal; Male; Muscarinic Agonists; Piloca | 2014 |
Identification of endogenous reference genes for the analysis of microRNA expression in the hippocampus of the pilocarpine-induced model of mesial temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; Hippocampus; Ma | 2014 |
The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
Topics: 4-Aminopyridine; Animals; Astrocytes; Bicuculline; Cell Survival; Cells, Cultured; Disease Models, A | 2014 |
Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; GABAergic Neurons; Gap Junctions; Glutam | 2014 |
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Biophysics; Carbamazepine; Convulsants; Disease Models, Animal; Electric S | 2014 |
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Topics: Adult; Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Fl | 2014 |
5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Pilocarpine; Rats, | 2015 |
Pharmacologically stimulated pupil and accommodative changes in Guinea pigs.
Topics: Accommodation, Ocular; Animals; Anterior Chamber; Corneal Topography; Disease Models, Animal; Guinea | 2014 |
Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality.
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Electroshock; Mice; Mice, Tr | 2014 |
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Epoxide Hydrolases; Hippocampus; Inflammat | 2015 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-A | 2014 |
Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mice; Micr | 2015 |
Direct effects of recurrent hypoglycaemia on adrenal catecholamine release.
Topics: Acetylcholine; Adrenal Glands; Animals; Blood Glucose; Cholinergic Agonists; Disease Models, Animal; | 2015 |
p75NTR, but not proNGF, is upregulated following status epilepticus in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Excitatory Amino Acid Agonists; | 2014 |
Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Hippocampus; Isoenzymes; Male; Mice, Inbred | 2014 |
Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Down-Regulation; Hippocampus; Indomethac | 2014 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate | 2014 |
Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus.
Topics: Animals; Cognition; Disease Models, Animal; Glutathione; Lithium; Male; Motor Activity; Oxidative St | 2014 |
Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.
Topics: Animals; Base Sequence; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Disease | 2014 |
Effects of muscarinic receptor modulators on ocular biometry of guinea pigs.
Topics: Accommodation, Ocular; Administration, Topical; Analysis of Variance; Animals; Anterior Chamber; Cyc | 2015 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Syne | 2015 |
Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model.
Topics: Animals; Benzamides; Cell Nucleus; Central Nervous System Agents; Cytoplasm; Dioxoles; Disease Model | 2014 |
Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Death; Cytidine Diphosphate Choline; Disease Model | 2015 |
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Catalase; Dexamethasone; Disease Models, Ani | 2015 |
Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Cell Survival; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Excit | 2015 |
ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission.
Topics: Action Potentials; Adenosine; Adolescent; Adult; Animals; Anterior Temporal Lobectomy; Anticonvulsan | 2015 |
Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures.
Topics: Action Potentials; Animals; Disease Models, Animal; Hippocampus; Interneurons; Mice; Mice, Knockout; | 2015 |
Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electric Stimulation; | 2015 |
Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2015 |
The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Epilepsy; Male; Piloc | 2014 |
Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats.
Topics: Animals; Apoptosis; Astrocytes; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Fluoxetine; Gluc | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Anticonvulsants; Cell Count; Chromatography, H | 2015 |
Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Electrocardiography; Epilepsy; Heart; Heart | 2015 |
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; cdc42 GTP-Binding Protein; Disease Models, Anim | 2015 |
Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Hippocamp | 2015 |
Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis.
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium Compounds; Male; Microelectrodes; Pilocarpine; | 2015 |
In vivo evaluation of anticonvulsant and antioxidant effects of phenobarbital microemulsion for transdermal administration in pilocarpine seizure rat model.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Emulsions | 2015 |
Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benzothiazoles; Disease Models, Animal; Infusions, Intra | 2015 |
The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epi | 2015 |
Transplantation of bone marrow mononuclear cells modulates hippocampal expression of growth factors in chronically epileptic animals.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chronic Disease; Disease Models, Animal; Ep | 2015 |
Distinct EEG seizure patterns reflect different seizure generation mechanisms.
Topics: 4-Aminopyridine; Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Male | 2015 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocamp | 2015 |
Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Connexin 43; Connexins; Disease Models, Animal; Electroencephalography; Gap Jun | 2015 |
The role of ubiquitin/Nedd4-2 in the pathogenesis of mesial temporal lobe epilepsy.
Topics: Adenosine Monophosphate; Analysis of Variance; Animals; Animals, Newborn; Antimanic Agents; Cells, C | 2015 |
EP2 Receptor Signaling Regulates Microglia Death.
Topics: Alprostadil; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Re | 2015 |
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disea | 2015 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
Pilocarpine-induced convulsive activity is limited by multidrug transporters at the rodent blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |
Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam.
Topics: Animals; Anticonvulsants; Brain Edema; Cell Death; Disease Models, Animal; Levetiracetam; Magnetic R | 2015 |
Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats.
Topics: Adaptor Proteins, Vesicular Transport; Adolescent; Adult; Animals; Brain; Disease Models, Animal; Dr | 2015 |
Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients.
Topics: Adult; Aged; Animals; Child; Disease Models, Animal; Drug Resistant Epilepsy; Epilepsy, Temporal Lob | 2015 |
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognition Disorders; Disease Models, Animal; | 2015 |
Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.
Topics: Analysis of Variance; Animals; Arginase; beta-N-Acetylhexosaminidases; Convulsants; Cytokines; Disea | 2015 |
Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Menstrual C | 2015 |
Fish oil provides protection against the oxidative stress in pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Fish Oils; Male; Neuroprotective Agents; Oxidative Stress | 2015 |
Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy.
Topics: Action Potentials; Animals; Brain Waves; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2015 |
Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models.
Topics: Animals; Antibodies; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencep | 2015 |
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Topics: Animals; Calpain; Disease Models, Animal; Epilepsy; Hippocampus; Levetiracetam; Pilocarpine; Piracet | 2015 |
Ischemic-hypoxic mechanisms leading to hippocampal dysfunction as a consequence of status epilepticus.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Hypoxia, Brai | 2015 |
Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Topics: Adamantane; Animals; Anticonvulsants; Arginine; CHO Cells; Cricetulus; Dipeptides; Disease Models, A | 2015 |
Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain.
Topics: Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Gene Expression Regulat | 2015 |
Dysregulation of long non-coding RNAs in mouse models of localization-related epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Mice; Pilocarpine; RNA, Long Noncoding | 2015 |
Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Phosphorylation; Pilocarpine; Rats; Ra | 2015 |
Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Pilocarp | 2015 |
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencep | 2015 |
Analysis of electrocorticographic patterns in rats fed standard or hyperlipidic diets in a normal state or during status epilepticus.
Topics: Algorithms; Alpha Rhythm; Animals; Beta Rhythm; Brain Waves; Computational Biology; Cortical Excitab | 2016 |
Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Caveolin 1; Cerebral Cortex; Disease Models, Animal; Endo | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures.
Topics: Animals; Biomarkers; Chemokine CCL2; Chemokine CCL3; Chemokine CCL5; Disease Models, Animal; Hippoca | 2015 |
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
Topics: Action Potentials; Aminoquinolines; Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cells, Cu | 2015 |
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Res | 2015 |
Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy.
Topics: Animals; Antioxidants; Cell Death; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal L | 2015 |
Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats.
Topics: Animals; Disease Models, Animal; Fenclonine; Gliosis; Hippocampus; Lithium; Magnetic Resonance Imagi | 2016 |
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; | 2015 |
Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Electrocorticography; Electrodes, Impl | 2015 |
Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epileps | 2015 |
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Diazepam; Disease Models, Animal; Enzym | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
GABAergic inhibition shapes interictal dynamics in awake epileptic mice.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Calcium; Calmodulin; Corpus Striatum; Disease M | 2015 |
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Case-Control Studies; Disease Models, Anim | 2015 |
Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.
Topics: Action Potentials; Adolescent; Adult; Animals; Blotting, Western; Disease Models, Animal; Down-Regul | 2016 |
The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus.
Topics: Animals; Calbindin 1; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Excitatory Post | 2015 |
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats.
Topics: Animals; Apoptosis Inducing Factor; Astrocytes; Calnexin; Disease Models, Animal; Endoplasmic Reticu | 2015 |
Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Adolescent; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Humans; | 2015 |
Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cytokines; Deep Brain Stimulation; Disease Mode | 2015 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport C | 2015 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus.
Topics: Animals; Cell Differentiation; Cell Movement; Cholera Toxin; Disease Models, Animal; Female; Follow- | 2015 |
Myeloperoxidase Nuclear Imaging for Epileptogenesis.
Topics: 4-Aminobenzoic Acid; Animals; Blotting, Western; Disease Models, Animal; Epilepsy; Flow Cytometry; M | 2016 |
Plic-1, a new target in repressing epileptic seizure by regulation of GABAAR function in patients and a rat model of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Anticonvulsants; Autophagy-Related | 2015 |
Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Brain Chemistry; Convulsants; CREB-Binding Protein; Disease Models, Animal; Female; Immunob | 2015 |
Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy.
Topics: Adult; Aged; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; | 2016 |
Protein-caloric dietary restriction inhibits mossy fiber sprouting in the pilocarpine model of TLE without significantly altering seizure phenotype.
Topics: Animals; Caloric Restriction; Diet, Protein-Restricted; Disease Models, Animal; Electroencephalograp | 2015 |
Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Male; Mice; Piloca | 2015 |
Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis.
Topics: Animals; Cell Differentiation; Diazepam; Disease Models, Animal; Epilepsy; Hippocampus; Muscarinic A | 2015 |
Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Lentivirus; Male; Neurofibr | 2016 |
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Lithium; | 2016 |
Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.
Topics: Action Potentials; Analysis of Variance; Animals; CA1 Region, Hippocampal; Dendrites; Disease Models | 2015 |
Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid A | 2015 |
The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus.
Topics: Actin Cytoskeleton; Actins; Analysis of Variance; Animals; Calcium-Binding Proteins; Cells, Cultured | 2015 |
Increased Expression of Rac1 in Epilepsy Patients and Animal Models.
Topics: Adult; Aminoquinolines; Animals; Behavior, Animal; Brain; Case-Control Studies; Disease Models, Anim | 2016 |
TRPV1 receptors augment basal synaptic transmission in CA1 and CA3 pyramidal neurons in epilepsy.
Topics: Animals; Capsaicin; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potenti | 2016 |
Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Axons; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mossy Fiber | 2016 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Aci | 2016 |
The pervasive reduction of GABA-mediated synaptic inhibition of principal neurons in the hippocampus during status epilepticus.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Poten | 2016 |
Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study.
Topics: Animals; Brain; Disease Models, Animal; Lithium Compounds; Magnetic Resonance Imaging; Male; Motor A | 2016 |
A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Basolateral Nuclear Complex; Catheters, Indwelling; Disease | 2016 |
N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.
Topics: Animals; Antigens, Nuclear; Chronic Disease; Depressive Disorder; Disease Models, Animal; Epilepsy; | 2016 |
Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups.
Topics: Animals; Animals, Newborn; Brain; Caspase 3; Disease Models, Animal; Electrocorticography; Electroen | 2016 |
Xenograft of human umbilical mesenchymal stem cells from Wharton's jelly as a potential therapy for rat pilocarpine-induced epilepsy.
Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; Human | 2016 |
Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.
Topics: Action Potentials; Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fema | 2016 |
Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?
Topics: Angiogenesis Inhibitors; Animals; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippo | 2016 |
Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Male; Maze | 2016 |
Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Amiloride; Animals; Anticonvulsants; B | 2015 |
CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Topics: Active Transport, Cell Nucleus; Animals; Convulsants; Cyclic AMP Response Element-Binding Protein; D | 2016 |
Salivary Alterations in Rats with Experimental Chronic Kidney Disease.
Topics: Amylases; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Isoproterenol; Male; Nep | 2016 |
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Disease Models, Animal; Drug Resistant Epilepsy | 2016 |
Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Convulsants; Disease Models, | 2016 |
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
Topics: Animals; Anticonvulsants; Apoptosis; Argonaute Proteins; Carbazoles; Convulsants; Disease Models, An | 2016 |
More Docked Vesicles and Larger Active Zones at Basket Cell-to-Granule Cell Synapses in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Linear Models; Male; Microscopy, Electron, | 2016 |
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Cell Movement; Disease Models, Animal; Gene Ex | 2016 |
The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy.
Topics: Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Encephalitis; Hippocampus; Interleu | 2016 |
Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Green Fluorescent Proteins; | 2016 |
Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures.
Topics: Animals; Anticonvulsants; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Male; M | 2016 |
Changes of AMPA receptor properties in the neocortex and hippocampus following pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Neocortex; Pilocar | 2016 |
Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice.
Topics: Actins; Analysis of Variance; Animals; Anxiety; Behavior Observation Techniques; Brain-Derived Neuro | 2016 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A | 2016 |
Characterization of Intracranial Pressure Behavior in Chronic Epileptic Animals: A Preliminary Study.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Tempor | 2016 |
Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat.
Topics: Animals; Convulsants; Disease Models, Animal; Hippocampus; Interleukin-1beta; Lithium; Pilocarpine; | 2016 |
Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.
Topics: Animals; Astrocytes; Axl Receptor Tyrosine Kinase; CD40 Antigens; Disease Models, Animal; Hippocampu | 2016 |
Rats with Malformations of Cortical Development Exhibit Decreased Length of AIS and Hypersensitivity to Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Axon Initial Segment; Disease Models, Animal; Female; Hypersensitivity; Malformations of Co | 2016 |
Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Convulsants; Disease Models, Animal; Fluoresceins; Ge | 2016 |
Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model.
Topics: Adenylate Kinase; Adolescent; Adult; Animals; Brain Injuries, Traumatic; Carrier Proteins; Child; Di | 2016 |
Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain.
Topics: Animals; Carrier Proteins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gree | 2016 |
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
Topics: Animals; Bone Density Conservation Agents; BRCA1 Protein; Breast; Breast Neoplasms; Carcinogenesis; | 2016 |
Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus.
Topics: Adamantane; Adenosine Triphosphate; Aminoquinolines; Animals; Disease Models, Animal; Excitatory Ami | 2017 |
The pilocarpine model of temporal lobe epilepsy: Marked intrastrain differences in female Sprague-Dawley rats and the effect of estrous cycle.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2016 |
Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Levetiraceta | 2016 |
Role of CA3 theta-modulated interneurons during the transition to spontaneous seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy; Interneurons; | 2016 |
Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia.
Topics: Animals; Disease Models, Animal; Hippocampus; Ischemic Preconditioning; Male; Memory Disorders; Neur | 2016 |
Hippocampal YKL-40 expression in rats after status epilepticus.
Topics: Animals; Antigens, Nuclear; Chitinase-3-Like Protein 1; Cytoplasm; Disease Models, Animal; Fluoresce | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice.
Topics: Animals; Calbindin 2; Calbindins; Dendrites; Disease Models, Animal; Female; GABAergic Neurons; Gene | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; C | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Fluorometry; Glycyrrhizic A | 2016 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocam | 2016 |
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
Abnormal Expression of FBXL20 in Refractory Epilepsy Patients and a Pilocarpine-Induced Rat Model.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy; F-Box Proteins; Female; Hippocampus; H | 2016 |
The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Agonists; Dentate Gyrus; Disease Models | 2016 |
Residual neurogenesis in chronically epileptic hippocampus of mice.
Topics: Animals; Bromodeoxyuridine; Cell Movement; Chronic Disease; Disease Models, Animal; Epilepsy; Female | 2016 |
Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats.
Topics: Animals; Anticonvulsants; Catalase; Diet; Disease Models, Animal; Hippocampus; Lipid Peroxidation; M | 2018 |
Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model.
Topics: Adolescent; Adult; Analysis of Variance; Animals; Brain; Calcium-Binding Proteins; Disease Models, A | 2016 |
Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, U | 2016 |
Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2016 |
Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; Gene Expression | 2016 |
Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation.
Topics: Animals; Binding Sites; Computational Biology; Disease Models, Animal; Humans; Mice; MicroRNAs; Musc | 2016 |
MicroRNA-139-5p negatively regulates NR2A-containing NMDA receptor in the rat pilocarpine model and patients with temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid | 2016 |
Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL/6 mice.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Male; Me | 2016 |
Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents.
Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tempor | 2017 |
Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment.
Topics: Animals; Blood-Brain Barrier; Cell Death; Choline O-Acetyltransferase; Cognition; Cognitive Dysfunct | 2017 |
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Glutamate-Ammo | 2017 |
Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.
Topics: Animals; Cell Differentiation; Cells, Cultured; Creatine; Disease Models, Animal; Embryo, Mammalian; | 2017 |
Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats.
Topics: Animals; Disease Models, Animal; Female; Motor Activity; Physical Conditioning, Animal; Pilocarpine; | 2016 |
Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na
Topics: Acetamides; Adult; Analysis of Variance; Animals; Anticonvulsants; Biophysics; Cells, Cultured; Dise | 2017 |
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Topics: Adolescent; Adult; Animals; Behavior, Animal; Case-Control Studies; Child; Disease Models, Animal; D | 2016 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal | 2017 |
Intraperitoneal injection of IL-4/IFN-γ modulates the proportions of microglial phenotypes and improves epilepsy outcomes in a pilocarpine model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Brain; Cognition Disorders; Disease Models, Animal; Epilepsy; Immunologic | 2017 |
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroence | 2017 |
Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depression; Disease Models, Animal; Drug Delive | 2017 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
Topics: Animals; Connexin 43; Connexins; Disease Models, Animal; Epilepsy; Gap Junction delta-2 Protein; Hip | 2017 |
Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist.
Topics: Animals; Atropine Derivatives; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Musca | 2017 |
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Electrocorticography; Electromyography; Epileps | 2016 |
Epilepsy and exercise: An experimental study in female rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Estrous Cycle; Femal | 2017 |
Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model.
Topics: Animals; Astrocytes; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Estradio | 2017 |
c-jun is differentially expressed in embryonic and adult neural precursor cells.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Embryonic Stem Cells; Female; Immunohistochemis | 2017 |
Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus.
Topics: Animals; Cognition; Deep Brain Stimulation; Disease Models, Animal; Electrocorticography; Explorator | 2017 |
Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.
Topics: Animals; Convulsants; Cytokines; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocamp | 2017 |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Count; Diazepam; Disease Models, Animal; Electric | 2017 |
VEGF regulates hippocampal neurogenesis and reverses cognitive deficits in immature rats after status epilepticus through the VEGF R2 signaling pathway.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Neuroge | 2017 |
PDI regulates seizure activity via NMDA receptor redox in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Ep | 2017 |
Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Membrane Glycoproteins | 2017 |
The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation; Interleukin-4; Leukocyt | 2017 |
Treatment of experimental status epilepticus with synergistic drug combinations.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2017 |
Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Disease Models, Animal; Lithium Chloride; Ma | 2017 |
Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis.
Topics: Animals; Cerebral Cortex; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; I | 2018 |
A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Calpain; Cerebral Cortex; Dipeptides; Disease Models, Animal; Dose-Respons | 2017 |
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Topics: Adolescent; Adult; Animals; Child; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; | 2017 |
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lo | 2017 |
Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Ischem | 2008 |
Characterization of osteopontin expression and function after status epilepticus.
Topics: Animals; CD11b Antigen; Cell Degranulation; Cells, Cultured; Disease Models, Animal; Electroshock; E | 2008 |
Retrosplenial granular b cortex in normal and epileptic rats: a stereological study.
Topics: Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Ep | 2008 |
Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
Topics: Animals; Chloride Channels; Chlorides; Disease Models, Animal; Epilepsy; Gene Expression Regulation; | 2008 |
Amiloride delays the onset of pilocarpine-induced seizures in rats.
Topics: Amiloride; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2008 |
Deducing the bioactive face of hydantoin anticonvulsant drugs using NMR spectroscopy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hydantoins; Magnetic Resonance Spectrosc | 2008 |
Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Gene Expression Regulation; Pilocarpine; Rats | 2008 |
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response | 2008 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Antipyrine; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone | 2009 |
Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy.
Topics: Animals; Biomarkers; Cell Count; Convulsants; Disease Models, Animal; Enzyme Activation; Epilepsy; E | 2008 |
Thalamic pathology in sudden cardiac death in epilepsy: a shed light on mysterious event.
Topics: Animals; Brain; Death, Sudden, Cardiac; Disease Models, Animal; Epilepsy, Temporal Lobe; Heart Arres | 2008 |
Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy, Tem | 2008 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
Status epilepticus produces chronic alterations in cardiac sympathovagal balance.
Topics: Analysis of Variance; Animals; Atropine; Baroreflex; Blood Pressure; Disease Models, Animal; Heart R | 2009 |
Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Epilepsy, Temporal Lobe; Gene Expres | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix Proteins; Fluorescei | 2008 |
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; El | 2008 |
Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
Topics: 4-Butyrolactone; Action Potentials; Administration, Oral; Animals; Anticonvulsants; Brain; Cerebral | 2008 |
Effect of electroacupuncture stimulation of hindlimb on seizure incidence and supragranular mossy fiber sprouting in a rat model of epilepsy.
Topics: Animals; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Electroacupuncture; Electrodes, Im | 2008 |
Serotonin depletion effects on the pilocarpine model of epilepsy.
Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, | 2008 |
Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cell Death; Cell Proliferation; Convulsants; Disease Models | 2008 |
Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Extracellular Fluid; Female; Gene Express | 2008 |
Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models | 2008 |
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
Topics: Analysis of Variance; Animals; Antigens, Surface; Brain; Cocaine; Dendrites; Disease Models, Animal; | 2008 |
Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calbindin 2; Cell Death; Cholera Toxin; Disease Models, Animal; DNA-Binding Proteins; Elect | 2009 |
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.
Topics: Animals; Calcium Channels, T-Type; Calcium Signaling; Channelopathies; Disease Models, Animal; Epile | 2008 |
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept | 2009 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cyclo | 2009 |
Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat.
Topics: Analysis of Variance; Animals; Conditioning, Classical; Disease Models, Animal; Electroshock; Emotio | 2009 |
Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regu | 2009 |
Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity.
Topics: Acepromazine; Analysis of Variance; Animals; Antipsychotic Agents; Body Weight; Disease Models, Anim | 2009 |
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner | 2009 |
Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Disease Models, Animal; Enzyme Induction; Male; Neu | 2009 |
Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Corpus Striatum; Disease Models, Animal; D | 2009 |
A simple quantitative method for analyzing electrographic status epilepticus in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; | 2009 |
h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Elec | 2009 |
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death.
Topics: Animals; Atropine; Brain-Derived Neurotrophic Factor; Cells, Cultured; Corpus Striatum; Cyclic AMP R | 2009 |
Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminoisobutyric Acids; Animals; Bicuculline; Disease Models, A | 2009 |
Upregulated TWIK-related acid-sensitive K+ channel-2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Atropine Derivatives; Cerebral Ventricles; Disease Models, Animal; Epilepsy, Te | 2009 |
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures.
Topics: Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroencephalo | 2009 |
Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; Fluorodeoxy | 2009 |
Large differences in blood measures, tissue weights, and focal areas of damage 1 year after postseizure treatment with acepromazine or ketamine.
Topics: Acepromazine; Analysis of Variance; Animals; Blood Pressure; Brain; Disease Models, Animal; Dopamine | 2009 |
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted | 2009 |
Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Progression; Dose-Response Re | 2009 |
Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Hippocampus; Immunohistochemistry | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Disease Susceptibility; Epilepsy, Temporal Lobe; Female; Glu | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
Down-regulation of APLP1 mRNA expression in hippocampus of pilocarpine-induced epileptic rats.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Base Sequence; Disease Models, Animal; | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2009 |
Erythropoietin pre-treatment prevents cognitive impairments following status epilepticus in rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Assoc | 2009 |
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Animals; Anxiety Disorders; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Epileps | 2009 |
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Topics: Animals; Cerebral Cortex; Chronic Disease; Convulsants; Cyclic AMP-Dependent Protein Kinases; Diseas | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Does pilocarpine-induced epilepsy in adult rats require status epilepticus?
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Inflammatio | 2009 |
Behavioral and histological assessment of the effect of intermittent feeding in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Eating; Epileps | 2009 |
Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Atropine Derivatives; Dentate Gyrus; Disease Models, Animal; Electric | 2009 |
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Atropine Derivatives; Axons; Dentate Gyrus; Disease Models, Animal; Epilep | 2009 |
Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model.
Topics: Age Factors; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Body Weight; Chi-Squ | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, D | 2009 |
A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats.
Topics: Action Potentials; Animals; Biophysics; Computer Simulation; Dentate Gyrus; Disease Models, Animal; | 2010 |
Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus.
Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Cell Death; Disease Models, Animal; Down-Reg | 2009 |
In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Benzamides; Brain; Brain Mapping; Corpus Striatum; Disease Models, Animal; | 2010 |
Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri.
Topics: Animals; Anticonvulsants; Bacopa; Carbamazepine; Disease Models, Animal; Epilepsy; Ergolines; Hippoc | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Disease Models, Animal; F | 2009 |
Nestin down-regulation of cortical radial glia is delayed in rats submitted to recurrent status epilepticus during early postnatal life.
Topics: Animals; Animals, Newborn; Biomarkers; Cerebral Cortex; Disease Models, Animal; Immunohistochemistry | 2009 |
Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Convulsants; Disease Models, Animal; Down-Regulation; Enzymes; Glutathione; G | 2010 |
Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.
Topics: Aconitine; Actin Cytoskeleton; Action Potentials; Animals; Arrhythmias, Cardiac; Biomarkers; Blood P | 2009 |
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.
Topics: Analysis of Variance; Anesthetics, Dissociative; Animals; Biogenic Monoamines; Body Weight; Brain; B | 2009 |
Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine: quantitative and topographic elemental analysis of brain tissue.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Male; Neuroprotective Agents; Pilocarpine; Rats; R | 2010 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calbin | 2010 |
Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Comorbidity; Convulsants; Depressive Disorder; Dis | 2010 |
Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Cell Size; Cell Survival; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal | 2009 |
Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine.
Topics: Acetates; Acute Disease; Animals; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; | 2010 |
Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Hippocampus; Humans; Im | 2009 |
Left hemisphere predominance of pilocarpine-induced rat epileptiform discharges.
Topics: Animals; Azides; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Functional Laterality | 2009 |
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
Topics: Animals; Antibodies, Antinuclear; Biomarkers; Body Weight; Cell Enlargement; Cell Proliferation; Cho | 2009 |
Pitfalls of high-pass filtering for detecting epileptic oscillations: a technical note on "false" ripples.
Topics: Algorithms; Animals; Artifacts; Biological Clocks; Brain Mapping; Convulsants; Disease Models, Anima | 2010 |
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Anima | 2010 |
Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids.
Topics: Administration, Oral; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine | 2010 |
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy.
Topics: Animals; Antigens; Blood-Brain Barrier; Capillaries; Cell Proliferation; Convulsants; Disease Models | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; F | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach.
Topics: Alcohol Drinking; Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonist | 2009 |
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Topics: Analysis of Variance; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Cathepsin D | 2010 |
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.
Topics: Analysis of Variance; Animals; Antigens, CD; Bone Marrow Transplantation; Cell Movement; Disease Mod | 2010 |
The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temp | 2010 |
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Dentate Gyr | 2010 |
Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.
Topics: Animals; Anticonvulsants; Behavioral Symptoms; Bicuculline; Carbamazepine; Cerebellum; Disease Model | 2010 |
E2F1-deficient NOD/SCID mice are an experimental model for dry mouth.
Topics: Animals; Disease Models, Animal; Drinking Behavior; E2F1 Transcription Factor; Mice; Mice, Inbred NO | 2009 |
Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy.
Topics: Animals; Cell Count; Dentate Gyrus; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinas | 2010 |
Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model.
Topics: Animals; Biophysics; Conditioning, Classical; Disease Models, Animal; Electric Stimulation; Excitato | 2010 |
Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Epilepsy; Female; Hipp | 2010 |
Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Post | 2010 |
Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
Topics: Animals; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Hindlimb; Hyperpolarizatio | 2010 |
Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Bromodeoxyuridine; Cell Count; Cell | 2010 |
Effect of ketogenic diet on nucleotide hydrolysis and hepatic enzymes in blood serum of rats in a lithium-pilocarpine-induced status epilepticus.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Aspartate Aminotransfe | 2010 |
Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Long-Term Potentiation | 2010 |
Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A.
Topics: Animals; Anticonvulsants; Bacopa; Basal Ganglia; Behavior, Animal; Bicuculline; Binding, Competitive | 2010 |
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiology; Ep | 2010 |
Prenatal stress potentiates pilocarpine-induced epileptic behaviors in infant rats both time and sex dependently.
Topics: Analysis of Variance; Animals; Animals, Newborn; Corticosterone; Disease Models, Animal; Epilepsy; F | 2010 |
[Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Humans; Interleukin 1 Receptor Antagonist Protein; I | 2010 |
Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 2010 |
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Arachidonic Acids; Blotting, Western; Cannabinoids; Dentate Gyrus; Disea | 2010 |
Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.
Topics: Age Factors; Alkanes; Analysis of Variance; Animals; Disease Models, Animal; Drug Interactions; Gene | 2010 |
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mossy Fibers, Hippocampal | 2010 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; | 2010 |
Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Hippocampus; Male; Oxidative St | 2011 |
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2010 |
Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus.
Topics: Animals; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Ma | 2010 |
Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity.
Topics: Adolescent; Adult; Albumins; Animals; Blood-Brain Barrier; Child, Preschool; Disease Models, Animal; | 2010 |
Inflammation enhances epileptogenesis in the developing rat brain.
Topics: Age Factors; Aging; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Gliosis; Inflamma | 2010 |
Proteomic profiling of the epileptic dentate gyrus.
Topics: Actins; Animals; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Electrophoresis, Gel | 2010 |
Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.
Topics: Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; H | 2010 |
Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
Topics: Animals; Convulsants; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocam | 2010 |
Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats.
Topics: Animals; Anticonvulsants; Caloric Restriction; Cerebral Cortex; Diet, Ketogenic; Dietary Carbohydrat | 2010 |
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbamates; Cell Line; Dipeptides; Disease Models, | 2010 |
Time course of neuronal damage in the hippocampus following lithium-pilocarpine status epilepticus in 12-day-old rats.
Topics: Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Hippocampus; Lithium Chloride; Mal | 2010 |
The protective effects of interleukin-18 and interferon-γ on neuronal damages in the rat hippocampus following status epilepticus.
Topics: Animals; Astrocytes; Disease Models, Animal; Hippocampus; Infusions, Intraventricular; Interferon ga | 2010 |
Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system.
Topics: Animals; CA3 Region, Hippocampal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroe | 2010 |
Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats.
Topics: Age Factors; Animals; Chronic Disease; Dendrites; Dentate Gyrus; Disease Models, Animal; Male; Maze | 2010 |
Seizures during pregnancy modify the development of hippocampal interneurons of the offspring.
Topics: Age Factors; Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Count; Disease Models, Animal | 2010 |
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
Topics: Animals; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Mice, Knockout; N- | 2010 |
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Death; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male | 2010 |
Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Behavioral Symptoms; Disease Models, Animal; Hipp | 2010 |
Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; Electric Stimulation Therapy; Hippocampus; Lithium Chloride; Male; | 2011 |
Changes in the numbers and distribution of calretinin in the epileptic rat hippocampus.
Topics: Analysis of Variance; Animals; Calbindin 2; Disease Models, Animal; Epilepsy; Gene Expression Regula | 2010 |
Tachycardias and sudden unexpected death in epilepsy: a gold rush by an experimental route.
Topics: Analysis of Variance; Animals; Death, Sudden; Disease Models, Animal; Electrocardiography; Epilepsy; | 2010 |
Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Calcium-Binding Proteins; Cell Count; Cerebral Cortex | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats.
Topics: Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2010 |
Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.
Topics: Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Gene Expression Regulati | 2010 |
Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy; Gene Expression; Hippocam | 2011 |
Expression and localization of annexin A7 in the rat lithium-pilocarpine model of acquired epilepsy.
Topics: Animals; Annexin A7; Calcium; Cerebral Cortex; Disease Models, Animal; Fluorescent Antibody Techniqu | 2010 |
Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitato | 2011 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
[Time course of COX-2 expression in hippocampus of the seizure rats].
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy; Hippocampus; Male; Pilocarpine; Random | 2009 |
Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric S | 2011 |
Heterogeneous integration of adult-generated granule cells into the epileptic brain.
Topics: Adult Stem Cells; Animals; Animals, Newborn; Cation Transport Proteins; Cell Count; Dendrites; Dendr | 2011 |
Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Epil | 2010 |
Study of spontaneous recurrent seizures and morphological alterations after status epilepticus induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Axons; Behavior, Animal; Brain; Chi-Square Distribution; Disease Models, Animal; Fluorescei | 2011 |
Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp.
Topics: Analysis of Variance; Animals; Dental Pulp; Disease Models, Animal; Drug Inverse Agonism; Inflammati | 2011 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Dise | 2011 |
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Disease Models, Animal; Electroencephalography; | 2011 |
Altered expression of Dscam in temporal lobe tissue from human and experimental animals.
Topics: Adolescent; Adult; Animals; Cell Adhesion Molecules; Child; Disease Models, Animal; Epilepsy, Tempor | 2011 |
Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Gliosis; Hippocampus; Kruppel-Like Factor 6; Kruppel-Like Transcrip | 2011 |
Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epileps | 2011 |
Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?
Topics: Analysis of Variance; Animals; Antioxidants; Cell Death; Disease Models, Animal; Hippocampus; Male; | 2011 |
Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cell Shape; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2011 |
Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agen | 2011 |
The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Count; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; Fluorescei | 2011 |
Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Malformations of Cortical Development; Methylazoxy | 2011 |
Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoxazines; Callithrix; Diazepam; Disease Models, | 2011 |
Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Blood Glucose; Disease Models, Animal; Epilepsy, | 2011 |
Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures.
Topics: Animals; Antigens, CD; Blood-Brain Barrier; Brain; Disease Models, Animal; Electroencephalography; F | 2011 |
Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Cytoskeletal Proteins; Disease Mod | 2011 |
Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus.
Topics: Animals; Disease Models, Animal; Hippocampus; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, | 2011 |
A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.
Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Memb | 2011 |
Improvement of the pilocarpine epilepsy model in rat using bone marrow stromal cell therapy.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lo | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Electroencephalography; Female; G | 2011 |
Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Lipopolysaccharides; Male; Piloc | 2011 |
Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity.
Topics: Action Potentials; Amphetamine; Analysis of Variance; Animals; Disease Models, Animal; Dopamine Agen | 2012 |
A cell-free extract from human adipose stem cells protects mice against epilepsy.
Topics: Adipose Tissue; Animals; Animals, Newborn; Anticonvulsants; Blood-Brain Barrier; Cell Extracts; Cell | 2011 |
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
Topics: Animals; Chi-Square Distribution; Circadian Rhythm; Disease Models, Animal; Electroencephalography; | 2011 |
An experimental study on dynamic morphological changes and expression pattern of GFAP and synapsin i in the hippocampus of MTLE models for immature rats.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Express | 2011 |
Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lo | 2011 |
Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy.
Topics: Adolescent; Adult; Animals; Astrocytes; Child; Child, Preschool; Disease Models, Animal; Epilepsy; F | 2011 |
Early physical exercise and seizure susceptibility later in life.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Disease Susceptibility; Epile | 2011 |
The roles of P2X7 receptor in regional-specific microglial responses in the rat brain following status epilepticus.
Topics: Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Male; Mi | 2012 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactio | 2011 |
Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.
Topics: Amides; Analysis of Variance; Animals; Anticonvulsants; Chromatography, Liquid; Disease Models, Anim | 2011 |
Impaired mitochondrial biogenesis in hippocampi of rats with chronic seizures.
Topics: Animals; Chronic Disease; Disease Models, Animal; DNA, Mitochondrial; Down-Regulation; Epilepsy; Hip | 2011 |
Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model.
Topics: Adolescent; Adult; Animals; Apelin; Blotting, Western; Brain; Case-Control Studies; Child; Disease M | 2011 |
Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Convulsants; Disease Models, Animal; Disease Pr | 2011 |
Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Green Fluore | 2011 |
Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Hipp | 2012 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Malnutrition in infancy as a susceptibility factor for temporal lobe epilepsy in adulthood induced by the pilocarpine experimental model.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus | 2011 |
Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.
Topics: Animals; Disease Models, Animal; Ghrelin; Kainic Acid; Male; Oligopeptides; Peptides; Pilocarpine; R | 2011 |
The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Astrocytes; Benzamides; Cell Count; Cognition Disorders; Disease Mode | 2012 |
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Antidepressive Agents; Behavior, Anima | 2011 |
The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Proliferation; Disease Models, Animal | 2012 |
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.
Topics: Alprostadil; Animals; Blood-Testis Barrier; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Ele | 2011 |
Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Catalase; Cognition Disorders; D | 2011 |
Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.
Topics: Abdominal Fat; Analysis of Variance; Animals; Chronic Disease; Disease Models, Animal; Energy Metabo | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
Investigating the role of zinc in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; Male; Pilocarpine | 2012 |
Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?
Topics: Animals; Critical Period, Psychological; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampu | 2011 |
Increased expression of calponin-3 in epileptic patients and experimental rats.
Topics: Adolescent; Adult; Animals; Brain; Calcium-Binding Proteins; Calponins; Disease Models, Animal; Elec | 2012 |
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2011 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; | 2011 |
Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cell Line, Tumor; Delayed Rectifier Potassium | 2012 |
Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; CA3 Region, Hippocampal; Dexamethasone; Dinoprostone; Diseas | 2012 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2012 |
Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus.
Topics: Animals; Antigens, Surface; Brain Edema; Cell Count; Chemokine CXCL2; Disease Models, Animal; Endoth | 2012 |
Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulati | 2012 |
Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Hippocampus; Interneurons; Male; M | 2012 |
Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.
Topics: Adolescent; Adult; Animals; Carrier Proteins; Disease Models, Animal; Dysbindin; Dystrophin-Associat | 2012 |
Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship | 2012 |
Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A.
Topics: Animals; Bacopa; Cerebral Cortex; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Ex | 2012 |
Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Topics: Animals; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Dentate Gyrus; Disease Models, An | 2012 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Brain Mapping; Diazepam; Disease Models, Animal; Epil | 2012 |
Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.
Topics: Aggression; Animals; Behavior, Animal; Disease Models, Animal; Immunosuppressive Agents; Physical St | 2012 |
Involvement of 5-HT₇ receptors in the pathogenesis of temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Behavior, Animal; Child; Disease Models, Animal; Electroencephalography; | 2012 |
Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.
Topics: Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors | 2012 |
Impairment of sexual function in rats with epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Muscarinic Agonists; Pilocarpine; Ra | 2012 |
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele | 2012 |
Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloheximide; Disease Models, Animal; Drug Interactions; Epilepsy; Hippoc | 2012 |
MK-801 prevents overexpression of multidrug resistance protein 2 after status epilepticus.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette S | 2012 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agoni | 2012 |
Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Animals, Newborn; Child; Disease Models, Animal; Epilepsy, Temporal L | 2012 |
Changes in interictal spike features precede the onset of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Brain Mapping; Brain Waves; Disease Models, Animal; Electrodes; Electroe | 2012 |
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.
Topics: Age Factors; Animals; Anticonvulsants; Atropine; Body Weight; Diazepam; Disease Models, Animal; Epil | 2012 |
Diversity and excitability of deep-layer entorhinal cortical neurons in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Dendrites; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal | 2012 |
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.
Topics: Animals; Anticholesteremic Agents; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electro | 2012 |
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Disease Progression; Fluoresceins | 2012 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Ep | 2013 |
Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electrodes, Implanted; Entropy; Image Proc | 2012 |
Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Disease Models, Animal; Jaw; Male; | 2013 |
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model.
Topics: Animals; Astrocytes; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fingol | 2012 |
Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2012 |
Cannabidivarin is anticonvulsant in mouse and rat.
Topics: Animals; Anticonvulsants; Cannabinoids; Cannabis; Disease Models, Animal; Female; Hippocampus; In Vi | 2012 |
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agoni | 2013 |
MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cell Death; Computational Biology; Disease Mode | 2012 |
Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Microscopy, Fluorescenc | 2012 |
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.
Topics: Animals; Animals, Newborn; Biotinylation; Calcium-Binding Proteins; Cell Adhesion Molecules, Neurona | 2012 |
Activity-dependent proteolytic cleavage of neuroligin-1.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Animals, Newborn; Biot | 2012 |
A strength exercise program in rats with epilepsy is protective against seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonists; Muscle F | 2012 |
Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Brain; Disease Models, Animal; Diseas | 2012 |
Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; As | 2012 |
Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats.
Topics: Animals; Blotting, Western; Brain; Convulsants; Dendritic Cells; Disease Models, Animal; Immunohisto | 2013 |
Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model.
Topics: Animals; Apoptosis; Atropine; Calpain; Chloral Hydrate; Disease Models, Animal; Hippocampus; Hypnoti | 2013 |
Early deficits in social behavior and cortical rhythms in pilocarpine-induced mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2013 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety?
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Cell Death; Disease Models, Animal; Dose-Res | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death.
Topics: Acetophenones; Animals; Cell Death; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocam | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice.
Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gu | 2013 |
Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains.
Topics: Age Factors; Animals; Anticonvulsants; Case-Control Studies; Cell Count; Disease Models, Animal; Dru | 2013 |
Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Tra | 2013 |
Sexual response in female rats with status epilepticus.
Topics: Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Female; Gonadal Steroid Hormo | 2013 |
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Disease Models, Animal; Hippocampus; Humans; I | 2013 |
Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Te | 2002 |
Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calc | 2002 |
Relations between brain pathology and temporal lobe epilepsy.
Topics: Animals; Brain; Cell Death; Cell Survival; Chronic Disease; Disease Models, Animal; Disease Progress | 2002 |
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.
Topics: Animals; Atropine Derivatives; Axons; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Fe | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anterior Thalamic Nuclei; Behavior, Animal; Disease Models, Animal; Male; Muscarinic Agonis | 2002 |
Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations.
Topics: Animals; Body Weight; Disease Models, Animal; Electroencephalography; Electrophysiology; Hippocampus | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Down-Regulation; En | 2002 |
Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain; Caspase 3; Caspases; Disease Models, Ani | 2002 |
Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model.
Topics: Age Factors; Animals; Brain Diseases; Cerebral Cortex; Disease Models, Animal; Entorhinal Cortex; Ep | 2002 |
Effect of topiramate following recurrent and prolonged seizures during early development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cell Death; Cognition; Convulsants; Disease | 2002 |
Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine Vaso | 2002 |
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; | 2003 |
The brain matrix and multifocal brain damage following a single injection of ketamine in young adult rats: conspicuous changes in old age.
Topics: Acepromazine; Age Factors; Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Ketamine; | 2002 |
Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Hippoc | 2003 |
Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.
Topics: Analysis of Variance; Animals; Antigens, CD; Atropine Derivatives; Axons; Calcium-Binding Proteins; | 2003 |
Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Atropine Derivatives; Cell Count; Dentate Gyrus; Disease Models, Animal; | 2003 |
Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Apoptosis; Caffeine; Convulsants; Disease Models, Animal; Dos | 2003 |
Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Cell Survival; Cycloheximide; Dentate Gyrus; D | 2003 |
Development of temporal lobe epilepsy in 21-day-old rats.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Magnetic Reso | 2003 |
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Behavior, Animal; Cell Death; Disease Models, Animal | 2003 |
Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats.
Topics: Animals; Anticonvulsants; Cells, Cultured; Dentate Gyrus; Disease Models, Animal; Electric Stimulati | 2003 |
Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.
Topics: Animals; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antago | 2003 |
Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus.
Topics: Animals; Animals, Newborn; Antazoline; Cell Count; Cells, Cultured; Cerebral Cortex; Disease Models, | 2003 |
In the lithium-pilocarpine model of epilepsy, brain lesions are not linked to changes in blood-brain barrier permeability: an autoradiographic study in adult and developing rats.
Topics: Age Factors; Animals; Autoradiography; Behavior, Animal; Blood Volume; Blood-Brain Barrier; Brain; D | 2003 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
[Temporal lobe epilepsy model induced by pilocarpine in rats].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Rats, Sprague-Daw | 2003 |
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Disease Models, Animal; Endocannabinoids; | 2003 |
Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; gamma-Am | 2003 |
Pilocarpine-induced seizures in adult rats: monoamine content and muscarinic and dopaminergic receptor changes in the striatum.
Topics: Animals; Biogenic Monoamines; Corpus Striatum; Disease Models, Animal; Female; Injections, Subcutane | 2003 |
Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures.
Topics: Animals; Calcium-Binding Proteins; Calponins; Dendrites; Dentate Gyrus; Disease Models, Animal; Epil | 2003 |
Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cell Count; Creatine; Diazepam; Disease Models, Animal; Epi | 2003 |
Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Kindli | 2003 |
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy.
Topics: Animals; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Hippoca | 2003 |
Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility.
Topics: Amino Acid Transport System X-AG; Animals; Cell Separation; Convulsants; Dentate Gyrus; Disease Mode | 2004 |
Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain.
Topics: Animals; Calcineurin; Calcium; Calcium Signaling; Cell Compartmentation; Cell Nucleus; Cerebral Cort | 2003 |
Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electric Stimulation Therapy; Electroence | 2004 |
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Topics: Animals; Blotting, Western; Brain; Densitometry; Disease Models, Animal; Immunohistochemistry; Male; | 2004 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cycloprop | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippoca | 2004 |
Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Hippoca | 2004 |
Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excit | 2004 |
Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Hematoma, Subdur | 2004 |
Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopam | 2004 |
Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Epilepsy; Ketamine; Male; Maze Learning; Pilocarpine; Rats; Rats, W | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cone | 2004 |
Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knocko | 2004 |
Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cytarabine; Disease M | 2004 |
Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain).
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Reflex; Limbic Sy | 2004 |
Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Dentate Gyrus; Disease Models, Anim | 2004 |
Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Transport; Calcium; Calcium-Transp | 2004 |
Neuronal and glial cell populations in the piriform cortex distinguished by using an approximation of q-space imaging after status epilepticus.
Topics: Amygdala; Animals; Cell Death; Convulsants; Diffusion Magnetic Resonance Imaging; Disease Models, An | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypote | 2004 |
[Neuronal damage in the hippocampus of inbred mouse strains in the models of epilepsy induced by kainic acid and pilocarpine].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strain | 2004 |
Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Densitometry; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Epilepsy, | 2004 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Feve | 2004 |
Carbamazepine enhances discriminative memory in a rat model of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Discrimination Learning; Disease Models, Animal; Drug Ad | 2004 |
Lithium ion "cyclotron resonance" magnetic fields decrease seizure onset times in lithium-pilocarpine seized rats.
Topics: Analysis of Variance; Animals; Cyclotrons; Disease Models, Animal; Dose-Response Relationship, Drug; | 2004 |
In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat.
Topics: Animals; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Lithium; Male; Muscari | 2004 |
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.
Topics: Animals; Brain; Cell Survival; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Dru | 2004 |
Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Interleuki | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; | 2004 |
The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response R | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response | 2005 |
Acute effects of glaucoma medications on rat intraocular pressure.
Topics: Animals; Antihypertensive Agents; Betaxolol; Disease Models, Animal; Dose-Response Relationship, Dru | 2005 |
Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hi | 2005 |
Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Bicuculline; Cell Count; Dendrites; Dendritic Spines; Disease Models, Animal; Epilepsy, Tem | 2005 |
Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glial Fibri | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Foc | 2005 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Cell Count; Disease Models, Animal; Entorhinal Cortex; Epilepsy, | 2005 |
Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Disease Models, Animal; Elec | 2005 |
A spontaneous recurrent seizure bioassay for anti-epileptogenic molecules.
Topics: Animals; Anticonvulsants; Biological Assay; Disease Models, Animal; Drug Evaluation, Preclinical; Ep | 2005 |
Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Disease Models, Animal; Hippocampus; Immunob | 2005 |
Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Denervation; Disease Models, Animal; Epilepsy, Temporal Lobe; H | 2005 |
Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus.
Topics: Animals; Benzenesulfonates; Brain; Cyclic N-Oxides; Disease Models, Animal; Electroencephalography; | 2005 |
Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine.
Topics: Animals; Disease Models, Animal; Female; Lithium; Male; Muscarinic Agonists; Pilocarpine; Rats; Seiz | 2005 |
The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2005 |
Anticonvulsant activity of androsterone and etiocholanolone.
Topics: 4-Aminopyridine; Androsterone; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; D | 2005 |
Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocampus; Levetiracetam; Male; Mic | 2005 |
Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats.
Topics: Acetylcholinesterase; Animals; Dentate Gyrus; Disease Models, Animal; Male; Mossy Fibers, Hippocampa | 2005 |
Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide.
Topics: Animals; Chronic Disease; Cycloheximide; Densitometry; Dentate Gyrus; Disease Models, Animal; GAP-43 | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2005 |
Proechimys guyannensis: an animal model of resistance to epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Hippo | 2005 |
Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation.
Topics: Animals; Chloramphenicol; Disease Models, Animal; Drug Carriers; Drug Evaluation; Eye; Eye Diseases; | 2005 |
Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Topics: Animals; Cycloheximide; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Estrogens; Estrous Cycle; Fema | 2005 |
[Qualitative study of hippocampal formation in hypertensive rats with epilepsy].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Hippocampus; Hypertension; Male; Neurons; | 2005 |
Modifications in muscarinic, dopaminergic and serotonergic receptors concentrations in the hippocampus and striatum of epileptic rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Epilepsy; Hippocampus; Male; Pil | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model.
Topics: Animals; Behavior, Animal; Brain Mapping; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calciu | 2005 |
Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy.
Topics: Adult; Animals; Antimetabolites; Biomarkers; Bromodeoxyuridine; Cell Differentiation; Cell Movement; | 2006 |
Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Triphosphatases; Age Factors; Analysis of Variance; | 2005 |
Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Long-Term Pote | 2006 |
Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Electron Transport Com | 2006 |
Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures.
Topics: Afferent Pathways; Animals; Calbindins; Cation Transport Proteins; Cell Count; Disease Models, Anima | 2005 |
Studies of damage to hippocampal neurons in inbred mouse lines in models of epilepsy using kainic acid and pilocarpine.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; HSP70 Heat-Shock Proteins; | 2005 |
Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Disease Models, Animal; | 2006 |
Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Cholera Toxin; Choline O-Acetyltransferase; Disease Mo | 2006 |
Weak, physiologically patterned magnetic fields do not affect maze performance in normal rats, but disrupt seized rats normalized with ketamine: possible support for a neuromatrix concept?
Topics: Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electromagnetic Fields; Ketami | 2006 |
Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, T | 2005 |
Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Hippocampus; Lovastatin; Male; Muscarinic A | 2005 |
[Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?].
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Epilepsy; Heart Rate; Male; | 2005 |
Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren's syndrome-associated autoantibodies.
Topics: Animals; Antibodies, Blocking; Autoantibodies; Carbachol; Disease Models, Animal; Dose-Response Rela | 2006 |
Functional properties and oxidative modulation of A-type K currents in hippocampal granule cells of control and chronically epileptic rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Impedance; Electric | 2006 |
Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Bicuculline; Chelating Agents; Disease Models, Animal; Drug Interactions | 2006 |
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study.
Topics: Amygdala; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Entorhinal Cortex; Fluoresce | 2006 |
Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Activation; Focal Adhesion Kinase 2; Guan | 2006 |
Effects of uridine in models of epileptogenesis and seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocam | 2006 |
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Te | 2006 |
Pro-epileptic effect of alfentanil in rats subjected to pilocarpine-induced chronic epilepsy.
Topics: Alfentanil; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Dose-Response Rela | 2006 |
Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Disease | 2006 |
Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Benzoquinones; Cell Count; Cell Death; Disease Models, Animal; Drug A | 2006 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Effect of glycemic state in rats submitted to status epilepticus during development.
Topics: Age Factors; Animals; Cell Count; Disease Models, Animal; Glucose Transporter Type 3; Glycemic Index | 2006 |
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Female; gamma-Aminobutyric Acid; | 2006 |
Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Hippocampus; Male; Muscarinic | 2006 |
Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons.
Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Dentate Gyrus; Disease Models, Ani | 2006 |
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Convulsants; Dentate Gyrus; Disease Models, A | 2006 |
Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Limbic System; Male; Muscarinic Agonists; Neurons; Pilo | 2006 |
Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Biomarkers; Convulsants; Disease Models, Animal; Electric Stimulation; E | 2006 |
Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Cell Count; Disease Models, Animal; Dr | 2006 |
Depression and/or potentiation of cortical responses after status epilepticus in immature rats.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography; Evok | 2007 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model.
Topics: Action Potentials; Animals; Chloride Channels; CLC-2 Chloride Channels; Convulsants; Dentate Gyrus; | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph | 2006 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response | 2006 |
Effect of levetiracetam on visual-spatial memory following status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Disease Models, Animal; Electroencephalograp | 2007 |
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fructo | 2007 |
Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy.
Topics: Action Potentials; Animals; Axons; Cerebral Cortex; Convulsants; Dentate Gyrus; Disease Models, Anim | 2006 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Preferential neuron loss in the rat piriform cortex following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Cerebral Cortex; Cholecystokinin; Disease Models, Animal; Immunohistochemistry; | 2007 |
Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death.
Topics: Analysis of Variance; Animals; Caspase 8; Caspase 9; Cell Count; Cell Death; Disease Models, Animal; | 2007 |
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease | 2007 |
Effect of interictal spikes on single-cell firing patterns in the hippocampus.
Topics: Action Potentials; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Flurot | 2007 |
Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitato | 2007 |
Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; GAP-43 Prot | 2007 |
Monitoring of acute generalized status epilepticus using multilocal diffusion MR imaging: early prediction of regional neuronal damage.
Topics: Acute Disease; Animals; Brain; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Dise | 2007 |
Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Epilepsy; Hippo | 2007 |
Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.
Topics: Animals; Cell Count; Cell Survival; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Glu | 2007 |
Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus.
Topics: Animals; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Hippocampus; Humans; Lithium | 2007 |
The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures.
Topics: Animals; Behavior, Animal; Chelating Agents; Disease Models, Animal; Drug Interactions; Edetic Acid; | 2007 |
Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats.
Topics: Animals; Catalase; Disease Models, Animal; Drug Interactions; Enzyme Activation; Hippocampus; Male; | 2007 |
Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzoates; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationsh | 2007 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain.
Topics: Animals; Animals, Newborn; Autophagy; Brain; Caspase 3; Cell Death; Disease Models, Animal; Dizocilp | 2007 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Ge | 2007 |
[Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy].
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; In Situ Hybridization; Lithium C | 2007 |
Anti-glutamatergic effect of riluzole: comparison with valproic acid.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Posts | 2007 |
Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study.
Topics: Action Potentials; Animals; Cell Death; Convulsants; Cortical Synchronization; Disease Models, Anima | 2007 |
The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.
Topics: Animals; Atropine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; J | 2007 |
Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures.
Topics: Action Potentials; Animals; Biomarkers; Calbindins; Calcitonin Gene-Related Peptide; Choristoma; Con | 2007 |
Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.
Topics: Animals; Astrocytes; Brain; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix P | 2007 |
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Dose-Response Relationship, Radiation; Down-Regul | 2007 |
In vivo and in vitro effects of pilocarpine: relevance to ictogenesis.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Electroencephalography; Guinea Pigs; Hi | 2007 |
Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Control Groups; Disease Models, Animal; Electrodes; Electroencephalograph | 2007 |
Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Image | 2007 |
Doublecortin-positive newly born granule cells of hippocampus have abnormal apical dendritic morphology in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Epil | 2007 |
Erythropoietin preconditioning suppresses neuronal death following status epilepticus in rats.
Topics: Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; BH3 Interacting | 2007 |
Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleat | 2007 |
An enriched environment improves cognitive performance after early-life status epilepticus accompanied by an increase in phosphorylation of extracellular signal-regulated kinase 2.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cognition; Disease Models, Animal | 2007 |
Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Diazepam; Disease Models, Animal; D | 2007 |
Inflammation exacerbates seizure-induced injury in the immature brain.
Topics: Acute Disease; Animals; Animals, Newborn; Body Temperature; Brain; Cell Count; Disease Models, Anima | 2007 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Hyperexcitability of the CA1 hippocampal region during epileptogenesis.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Ele | 2007 |
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Death; Chelating Agents; Dise | 2007 |
Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Disease Models, Animal; Lithium Chloride; Pilocar | 2007 |
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Count; Disease Models, Animal; Electroencephalography; Epi | 2008 |
A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation.
Topics: Animals; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2008 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxygl | 2007 |
Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liqu | 2007 |
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
Topics: Animals; Channelopathies; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Disease Models, Animal | 2007 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dop | 2008 |
Cytoarchitectonics and afferent/efferent reorganization of neurons in layers II and III of the lateral entorhinal cortex in the mouse pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Fluorescent Antibody Te | 2008 |
Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract.
Topics: Analysis of Variance; Animals; Bacopa; Behavior, Animal; Disease Models, Animal; Dose-Response Relat | 2008 |
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
Topics: Animals; Biotinylation; Disease Models, Animal; Endocytosis; Enzyme Inhibitors; Hippocampus; Immunop | 2008 |
Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma.
Topics: Adrenal Cortex Hormones; Animals; Anterior Chamber; Cholinergic Agonists; Conjunctival Diseases; Dis | 2007 |
Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopamine; Dose-Response Relatio | 2008 |
Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; | 2008 |
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Disease Models, Animal; Encephalitis; Epilepsy, Tempo | 2008 |
Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epileps | 2008 |
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Resp | 2008 |
Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus.
Topics: Animals; Benzamides; Cell Death; Convulsants; Disease Models, Animal; Glutathione; Heme Oxygenase (D | 2008 |
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chronic Disease; Convulsants; Disease Models, Animal; Down- | 2008 |
Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins.
Topics: Analysis of Variance; Animals; Brain Injuries; Calbindin 2; Cell Count; Disease Models, Animal; Epil | 2008 |
Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
Topics: Animals; Cell Death; Ceramides; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid A | 2008 |
Inflammation modifies status epilepticus-induced hippocampal injury during development.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Hippocampus; Inflammation; Kainic Acid; Li | 2007 |
Effective treatments of prolonged status epilepticus in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, | 2008 |
Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Animals; Cloning, Molecular; Disease Models, Anima | 2008 |
Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Knockout; Pilocarpine; Status E | 2008 |
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relati | 2008 |
Chemoconvulsant model of chronic spontaneous seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroshock; Excitatory Amino Acid Agonists; Kai | 2005 |
Temporal lobe epilepsy and social behavior: an animal model for autism?
Topics: Animals; Autistic Disorder; Behavior, Animal; Discrimination, Psychological; Disease Models, Animal; | 2008 |
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Model | 2008 |
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Convulsants; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2008 |
[The effect of low frequency transcranial magnetic stimulation on neuropeptide-Y expression and apoptosis of hippocampus neurons in epilepsy rats induced by pilocarpine].
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Neurons; Neu | 2007 |
A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus.
Topics: Actins; Analysis of Variance; Animals; Brain; Calcineurin; Dendrites; Dendritic Spines; Disease Mode | 2008 |
Erythropoietin reduces epileptogenic processes following status epilepticus.
Topics: Analysis of Variance; Animals; Brain; Bromodeoxyuridine; Capillary Permeability; CD11b Antigen; Cell | 2008 |
Effect of TTX suppression of hippocampal activity following status epilepticus.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Electroencephalography; H | 2008 |
Exocrine pancreatic secretion in rats treated with reserpine after stimulation with pilocarpine, dopamine, and caerulein.
Topics: Amylases; Animals; Bicarbonates; Ceruletide; Chlorides; Cystic Fibrosis; Disease Models, Animal; Dop | 1980 |
The chronically reserpinized rat as a model for cystic fibrosis: alterations in pancreatic enzyme secretion and storage.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsin; Cystic Fibrosis; Disease Models, Animal; Male; Pan | 1981 |
Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis.
Topics: Animals; Brain; Brain Diseases; Cholinergic Fibers; Disease Models, Animal; Electroencephalography; | 1984 |
[Comparative study of the antiglaucomatous activity of Glauplex 2 and pilocarpine nitrate on alpha-chymotrypsin-induced experimental glaucoma].
Topics: Animals; Chymotrypsin; Delayed-Action Preparations; Disease Models, Animal; Glaucoma; Ophthalmic Sol | 1982 |
Composition of pulmonary lavage fluid in control and reserpine-treated rats following chronic isoproterenol and pilocarpine administration.
Topics: Animals; Body Fluids; Carbohydrates; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lipids; | 1980 |
Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Situ Hybridization; Male; Nerve Growth Fa | 1995 |
Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.
Topics: Animals; Cerebellar Nuclei; Disease Models, Animal; Epilepsy, Complex Partial; Hippocampus; Lysine; | 1995 |
Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Complex Partial; | 1995 |
Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electro | 1995 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity | 1995 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Sy | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy.
Topics: Animals; Dinoprost; Dinoprostone; Disease Models, Animal; Epilepsy; Hippocampus; Male; Muscarinic Ag | 1995 |
Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Ki | 1996 |
The pilocarpine model of epilepsy in mice.
Topics: Animals; Coloring Agents; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; E | 1996 |
Developmental aspects of the pilocarpine model of epilepsy.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Male; Pilocarpine; | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Fluoride and pilocarpine reduce the risk of caries produced by chronic clomipramine treatment in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Cariostatic Agents; Cholinergic Antagonists; Cl | 1997 |
Lithium-pilocarpine status epilepticus in the immature rabbit.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Hippocampus; Lithium Carbonate; Neur | 1997 |
Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs.
Topics: Acetylcholine; Acetylcholinesterase; Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchial | 1997 |
Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Pilocarpine; Rats; Ra | 1997 |
Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain; Brain Injuries; Disease Models, Animal; Electroshoc | 1997 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, | 1997 |
Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Disease | 1997 |
Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
Topics: Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy | 1997 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
Tyrosine phosphorylation is increased in the rat hippocampus during the status epilepticus induced by pilocarpine.
Topics: Animals; Blotting, Western; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Phospho | 1998 |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electro | 1998 |
Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Ionto | 1998 |
Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat.
Topics: Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Radiation; | 1999 |
Loss of NADPH diaphorase-positive neurons in the hippocampal formation of chronic pilocarpine-epileptic rats.
Topics: Animals; Biomarkers; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epil | 1999 |
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression R | 1999 |
Facilitation of seizures in limbic epileptic rats by complex 1 microTesla magnetic fields.
Topics: Animals; Disease Models, Animal; Electromagnetic Fields; Limbic System; Lithium Chloride; Male; Pilo | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult Rat.
Topics: Age Factors; Animals; Behavior, Animal; Benzoxazines; Brain Stem; Carbon Radioisotopes; Cell Death; | 2000 |
Effect of muscarinic receptor agonists on animal models of psychosis.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Disease Models, Animal; Dose-Response | 2000 |
Ultrastructural identification of dentate granule cell death from pilocarpine-induced seizures.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Human | 2000 |
Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Lipid Pe | 2000 |
Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Lysine; Male; Mo | 2000 |
The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice.
Topics: Animals; Calbindin 2; Cell Death; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2000 |
Multiple pilocarpine-induced status epilepticus in developing rats: a long-term behavioral and electrophysiological study.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; E | 2000 |
Does status epilepticus influence the motor development of immature rats?
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Exploratory Behavi | 2000 |
Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; Hippocampus; Humans; Neu | 2000 |
The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Electroshock; Kindling, Neurologi | 2000 |
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Epilepsia Partiali | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyru | 2001 |
An animal model of nonconvulsive status epilepticus: a contribution to clinical controversies.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Humans; Lith | 2001 |
Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus.
Topics: Action Potentials; Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Excitatory | 2001 |
Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Disease Models, Animal; Disease Progression; | 2001 |
Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
Topics: Acetylcholine; Animals; Choline; Disease Models, Animal; Female; Injections, Intraperitoneal; Isopro | 2001 |
Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Calcium; Calcium Channel Blockers; | 2001 |
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Apoptosis; Avian Proteins; Basigin; Bl | 2001 |
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; | 2001 |
Exploring the potential for subtype-selective muscarinic agonists in glaucoma.
Topics: Animals; Disease Models, Animal; Female; Glaucoma; Intraocular Pressure; Macaca fascicularis; Muscar | 2001 |
The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Disease Models, Animal; Epilepsy; Glutamate Decarboxyl | 2001 |
A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus.
Topics: Animals; Brain; Calcineurin; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Hippocamp | 2001 |
Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity.
Topics: Action Potentials; Animals; Axons; Dendrites; Dentate Gyrus; Disease Models, Animal; Electric Stimul | 2001 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; | 2001 |
Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2002 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; | 2002 |
Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.
Topics: Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; GABA | 2002 |
Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Separation; Dis | 2002 |
Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study.
Topics: Animals; Antimetabolites; Autoradiography; Brain; Deoxyglucose; Disease Models, Animal; Energy Metab | 2002 |
Castration in female rats modifies the development of the pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Ovariectomy; Pilocarpine; Rats; Rats | 2002 |
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2002 |
The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures.
Topics: Aminoacetonitrile; Animals; Blotting, Western; Cell Death; Disease Models, Animal; Enzyme Activation | 2002 |
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; E | 2002 |
[Experimental ulcer].
Topics: Animals; Caffeine; Cats; Cattle; Chickens; Disease Models, Animal; Dogs; Ducks; Guinea Pigs; Haplorh | 1975 |
[Rabbit experimental glaucoma--preliminary study (author's transl)].
Topics: Aminocaproates; Aminocaproic Acid; Animals; Disease Models, Animal; Disseminated Intravascular Coagu | 1978 |
The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
Topics: Animals; Body Weight; Cell Nucleus; Cystic Fibrosis; Cytoplasm; Disease Models, Animal; Endoplasmic | 1975 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
A new model for neonatal pulmonary hemorrhage research.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hemorrhage; Humans; Infant, Newborn; Infa | 1975 |
Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain.
Topics: Animals; Brain; Disease Models, Animal; Hippocampus; Hydrolysis; In Vitro Techniques; Lithium; Male; | 1992 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Piloc | 1992 |
The effects of glaucoma medications on Tenon's capsule and conjunctiva in the rabbit.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Conjunctiva; Disease Models, Animal; Epin | 1991 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; D | 1991 |
Lateral striatal cholinergic mechanisms involved in oral motor activities in the rat.
Topics: Animals; Catheterization; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; | 1990 |
Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroenc | 1990 |
Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels.
Topics: Administration, Topical; Animals; Colforsin; Disease Models, Animal; Female; Keratoconjunctivitis; K | 1990 |
Transrectal ultrasonography as a method to monitor canine prostatic size in situ: measurements following endocrine manipulation and ejaculation.
Topics: Animals; Disease Models, Animal; Dogs; Ejaculation; Male; Orchiectomy; Organ Size; Pilocarpine; Pros | 1989 |
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol | 1988 |
X-ray microanalysis of exocrine glands in animal models for cystic fibrosis.
Topics: Adrenergic beta-Agonists; Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; El | 1985 |
Animal models of neuroleptic-induced acute dystonia.
Topics: Acute Disease; Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Dystonia; Glutamate Dec | 1988 |
Effects of chronic furosemide treatment on rat exocrine glands.
Topics: Animals; Biological Transport; Cations; Chlorides; Cystic Fibrosis; Disease Models, Animal; Exocrine | 1988 |
The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, | 1987 |
Laser-induced glaucoma in rabbits.
Topics: Animals; Aqueous Humor; Colforsin; Disease Models, Animal; Glaucoma; Lasers; Ocular Hypertension; Op | 1986 |
The chronically pilocarpine-treated rat in the study of cystic fibrosis: investigations on submandibular gland and pancreas.
Topics: Animals; Carbachol; Cystic Fibrosis; Disease Models, Animal; Electron Probe Microanalysis; Energy Me | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Some anticholinergic activities of BRL 1288--a new anti-Parkinson drug.
Topics: Animals; Disease Models, Animal; Glycolates; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle, | 1969 |
Experimental myopia in rabbits.
Topics: Animals; Atropine; Body Temperature; Disease Models, Animal; Epinephrine; Eye; Female; Intraocular P | 1970 |