Page last updated: 2024-11-07

pilocarpine and Diathesis

pilocarpine has been researched along with Diathesis in 33 studies

Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.

Research Excerpts

ExcerptRelevanceReference
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."7.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
"Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats."7.72Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003)
" In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy."7.72Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004)
" In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats."7.71Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002)
"The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions."7.71Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001)
"The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI."5.62Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021)
"No overt motor seizures were observed in this age group."5.27The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987)
" Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively."4.77Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988)
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."3.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
" We found that inhibition of mTOR by rapamycin in immature rats (3-4 weeks old) increases the severity of seizures induced by pilocarpine, including lengthening the total seizure duration and reducing the latency to the onset of seizures."3.78Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. ( Huang, X; Huang, Y; McMahon, J; Shin, D; Yang, J, 2012)
" We assessed the susceptibility to epilepsy after subthreshold dose of pilocarpine, as well as glial fibrillary acidic protein (GFAP) expression using immunohistochemistry."3.78Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine. ( Feng, B; Pan, XH; Sun, HL; Wang, CY; Xu, Y; Yang, LX; Zhang, SH; Zhang, SP; Zhong, K; Zhu, W, 2012)
" This "period without stimulus" was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150."3.77Early physical exercise and seizure susceptibility later in life. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Scorza, FA; Silva Araújo, BH, 2011)
"Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)."3.75Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009)
"Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats."3.72Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003)
" In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy."3.72Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004)
" In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats."3.71Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002)
" beta2(-/-) mice displayed increased susceptibility to seizures, as indicated by reduced latency and threshold for pilocarpine-induced seizures, but seemed normal in other neurological tests."3.71Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. ( Avery, C; Bharucha, V; Brown, A; Catterall, WA; Chen, C; Chen, Y; Gillespie, PJ; Isom, LL; Jones, D; Kazarinova-Noyes, K; Kazen-Gillespie, KA; Macdonald, RL; Malhotra, JD; Ransom, BR; Saunders, TL; Scheuer, T; Shrager, P; Westenbroek, RE, 2002)
"The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions."3.71Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001)
" In addition, both homozygous and heterozygous mutant mice are highly resistant to the seizures produced by systemic administration of the muscarinic agonist pilocarpine."3.69Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. ( Hamilton, SE; Hille, B; Idzerda, RL; Levey, AI; Loose, MD; McKnight, GS; Nathanson, NM; Qi, M, 1997)
"The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI."1.62Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021)
"Cortical dysplasia is the most common etiology of intractable epilepsy."1.48Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia. ( Feng, L; Wang, YL; Xiao, B; Yue, ZW, 2018)
"In rats with frequent severe seizures, we found a clear loss of Prox1 and NeuN expression in the dentate granule cell layer (GCL), which was confined mainly to the suprapyramidal blade of the GCL at the septal and middle regions of the septotemporal axis of the hippocampus."1.46Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus. ( Seki, T; Toda, K; Uemori, T, 2017)
"TRPC6 knockdown increased seizure susceptibility, excitability ratio and paired-pulse inhibition in the dentate gyrus (DG) of normal animals."1.42The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. ( Kang, TC; Kim, YJ, 2015)
"At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring."1.39Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013)
"Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function and susceptibility to arrhythmias have not been directly investigated."1.35Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. ( Bealer, SL; Little, JG; Metcalf, CS; Poelzing, S, 2009)
"Prolonged seizures in early childhood are associated with an increased risk of development of epilepsy in later life."1.32Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. ( Brooks-Kayal, AR; Hsu, FC; Raol, YS; Zhang, G, 2004)
"No overt motor seizures were observed in this age group."1.27The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19903 (9.09)18.7374
1990's2 (6.06)18.2507
2000's14 (42.42)29.6817
2010's12 (36.36)24.3611
2020's2 (6.06)2.80

Authors

AuthorsStudies
Sakai, K1
Takata, F1
Yamanaka, G1
Yasunaga, M1
Hashiguchi, K1
Tominaga, K1
Itoh, K1
Kataoka, Y1
Yamauchi, A1
Dohgu, S1
Sano, F1
Shigetomi, E1
Shinozaki, Y1
Tsuzukiyama, H1
Saito, K1
Mikoshiba, K1
Horiuchi, H1
Cheung, DL1
Nabekura, J1
Sugita, K1
Aihara, M1
Koizumi, S1
Uemori, T1
Toda, K1
Seki, T1
Yue, ZW1
Wang, YL1
Xiao, B1
Feng, L1
Yin, P1
Liu, J1
Li, Z1
Wang, YY1
Qiao, NN1
Huang, SY1
Li, BM1
Sun, RP1
López-López, J1
Jané Salas, E1
Chimenos Küstner, E1
Epps, SA1
Kahn, AB1
Holmes, PV1
Boss-Williams, KA1
Weiss, JM1
Weinshenker, D1
Kim, YJ1
Kang, TC1
Thyrion, L1
Portelli, J2
Raedt, R1
Glorieux, G1
Larsen, LE1
Sprengers, M1
Van Lysebettens, W1
Carrette, E1
Delbeke, J1
Vonck, K1
Boon, P1
Trindade-Filho, EM1
de Castro-Neto, EF1
de A Carvalho, R1
Lima, E1
Scorza, FA2
Amado, D1
Naffah-Mazzacoratti, Mda G1
Cavalheiro, EA4
Blanco, MM1
dos Santos, JG1
Perez-Mendes, P1
Kohek, SR1
Cavarsan, CF1
Hummel, M1
Albuquerque, C1
Mello, LE2
Peternel, S1
Pilipović, K1
Zupan, G1
Metcalf, CS1
Poelzing, S1
Little, JG1
Bealer, SL1
Gomes da Silva, S1
de Almeida, AA1
Silva Araújo, BH1
Arida, RM1
Bankstahl, M1
Müller, CJ1
Wilk, E1
Schughart, K1
Löscher, W1
Huang, X1
McMahon, J1
Yang, J1
Shin, D1
Huang, Y1
Thielemans, L1
Ver Donck, L1
Loyens, E1
Coppens, J1
Aourz, N1
Aerssens, J1
Vermoesen, K1
Clinckers, R1
Schallier, A1
Michotte, Y1
Moechars, D1
Collingridge, GL1
Bortolotto, ZA3
Smolders, I1
Zhu, W1
Zhang, SH1
Feng, B1
Zhong, K1
Yang, LX1
Sun, HL1
Zhang, SP1
Xu, Y1
Wang, CY1
Pan, XH1
Nehlig, A1
Dubé, C1
Koning, E1
Chen, C1
Bharucha, V1
Chen, Y1
Westenbroek, RE1
Brown, A1
Malhotra, JD1
Jones, D1
Avery, C1
Gillespie, PJ1
Kazen-Gillespie, KA1
Kazarinova-Noyes, K1
Shrager, P1
Saunders, TL1
Macdonald, RL1
Ransom, BR1
Scheuer, T1
Catterall, WA1
Isom, LL1
Druga, R1
Kubová, H1
Suchomelová, L1
Haugvicová, R1
Setkowicz, Z1
Janeczko, K1
MEENA, AL1
CONN, JH1
NAUMANN, H1
HARDY, JD1
Zhang, G1
Raol, YS1
Hsu, FC1
Brooks-Kayal, AR1
Brenneke, F1
Bukalo, O1
Dityatev, A1
Lie, AA1
Choi, IS1
Cho, JH1
Lee, MG1
Choi, BJ1
Scharfman, HE1
Goodman, JH1
Rigoulot, MA1
Berger, RE1
Walling, SG1
Mercurio, TC1
Stormes, K1
Maclusky, NJ1
Guidine, PA1
Rezende, GH1
Queiroz, CM1
Prado, VF1
Prado, MA1
Pereira, GS1
Moraes, MF1
Hamilton, SE1
Loose, MD1
Qi, M1
Levey, AI1
Hille, B1
McKnight, GS1
Idzerda, RL1
Nathanson, NM1
Gulec, G1
Noyan, B1
Heim, C1
Sontag, KH1
Meldrum, B1
Millan, M1
Patel, S1
de Sarro, G1
Silva, DF1
Turski, WA1
Calderazzo-Filho, LS1
Turski, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.[NCT05585476]98 participants (Anticipated)Interventional2022-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for pilocarpine and Diathesis

ArticleYear
[Prognosis and treatment of dry mouth. Systematic review].
    Medicina clinica, 2014, Feb-04, Volume: 142, Issue:3

    Topics: Cholinergic Antagonists; Clinical Trials as Topic; Dental Caries; Disease Susceptibility; Double-Bli

2014
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
    Journal of neural transmission, 1988, Volume: 72, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su

1988

Other Studies

31 other studies available for pilocarpine and Diathesis

ArticleYear
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice.
    Journal of pharmacological sciences, 2021, Volume: 145, Issue:1

    Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Susceptibility; Gene Expression;

2021
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
    JCI insight, 2021, 05-10, Volume: 6, Issue:9

    Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept

2021
Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus.
    Hippocampus, 2017, Volume: 27, Issue:10

    Topics: Animals; Antigens, Nuclear; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Doublecor

2017
Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia.
    Neurochemical research, 2018, Volume: 43, Issue:4

    Topics: Animals; Axon Initial Segment; Axons; Disease Models, Animal; Disease Susceptibility; Electroencepha

2018
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
    Brain research, 2013, Jun-26, Volume: 1519

    Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili

2013
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.
    Epilepsy & behavior : E&B, 2013, Volume: 29, Issue:1

    Topics: Animals; Depression; Disease Models, Animal; Disease Susceptibility; Epilepsy; Galanin; Gene Express

2013
The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus.
    Neuroscience, 2015, Oct-29, Volume: 307

    Topics: Animals; Calbindin 1; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Excitatory Post

2015
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B

2016
Serotonin depletion effects on the pilocarpine model of epilepsy.
    Epilepsy research, 2008, Volume: 82, Issue:2-3

    Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models,

2008
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
    Epilepsia, 2009, Volume: 50, Issue:4

    Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept

2009
Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Apr-30, Volume: 33, Issue:3

    Topics: Animals; Brain; Disease Models, Animal; Disease Susceptibility; Epilepsy, Temporal Lobe; Female; Glu

2009
Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:6

    Topics: Aconitine; Actin Cytoskeleton; Action Potentials; Animals; Arrhythmias, Cardiac; Biomarkers; Blood P

2009
Early physical exercise and seizure susceptibility later in life.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011, Volume: 29, Issue:8

    Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Disease Susceptibility; Epile

2011
Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.
    Behavioural brain research, 2012, Apr-21, Volume: 230, Issue:1

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship

2012
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.
    Neuroscience, 2012, Sep-06, Volume: 219

    Topics: Animals; Anticonvulsants; Blotting, Western; Convulsants; Disease Susceptibility; Down-Regulation; I

2012
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012, Volume: 9, Issue:3

    Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil

2012
Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.
    Epilepsy & behavior : E&B, 2012, Volume: 25, Issue:3

    Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Brain; Disease Models, Animal; Diseas

2012
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
    Epilepsy research, 2002, Volume: 51, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility;

2002
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Dec-24, Volume: 99, Issue:26

    Topics: Action Potentials; Animals; Disease Susceptibility; Mice; Mice, Knockout; Nerve Fibers; Neural Condu

2002
Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent.
    Physiological research, 2003, Volume: 52, Issue:2

    Topics: Aging; Animals; Brain; Cerebral Cortex; Disease Susceptibility; Lithium; Pilocarpine; Rats; Status E

2003
Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages.
    Epilepsy research, 2003, Volume: 53, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Disease Susceptibility; Drug Res

2003
Pepsin in gastric physiology: effect of ulcer diathesis, ACTH, histamine, anesthesia-operation, banthine, pilocarpine, epinephrine, and sedation upon blood and urine pepsin levels and upon gastric acidity.
    Surgical forum, 1957, Volume: 7

    Topics: Adrenocorticotropic Hormone; Anesthesia; Disease Susceptibility; Enzyme Precursors; Epinephrine; Gas

1957
Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility.
    Journal of neurochemistry, 2004, Volume: 88, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Cell Separation; Convulsants; Dentate Gyrus; Disease Mode

2004
Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy.
    Neuroscience, 2004, Volume: 124, Issue:4

    Topics: Animals; Astrocytes; Biomarkers; Calbindin 2; Cell Count; Convulsants; Disease Susceptibility; Elect

2004
Pilocarpine-induced seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:8

    Topics: Animals; Disease Susceptibility; Female; Immunohistochemistry; Maternal Exposure; Methylazoxymethano

2005
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine.
    Experimental neurology, 2005, Volume: 196, Issue:1

    Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Estrogens; Estrous Cycle; Fema

2005
Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: Animals; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Knockout; Pilocarpine; Status E

2008
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Nov-25, Volume: 94, Issue:24

    Topics: Animals; Behavior, Animal; Disease Susceptibility; Kainic Acid; Ligands; Mice; Mice, Knockout; Musca

1997
Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
    Brain research. Developmental brain research, 2001, Feb-28, Volume: 126, Issue:2

    Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Disease Models, Animal; Disease Progression;

2001
Transient occlusion of rat carotid arteries decreases susceptibility to pilocarpine seizures.
    Brain research, 1991, Mar-29, Volume: 544, Issue:2

    Topics: Animals; Behavior, Animal; Carotid Arteries; Cerebrovascular Circulation; Constriction; Disease Susc

1991
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
    Brain research, 1987, Dec-15, Volume: 465, Issue:1-2

    Topics: Aging; Animals; Behavior, Animal; Brain; Disease Susceptibility; Electroencephalography; Female; Mal

1987