pilocarpine has been researched along with Diathesis in 33 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 7.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| " In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy." | 7.72 | Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 7.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 5.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "No overt motor seizures were observed in this age group." | 5.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " We found that inhibition of mTOR by rapamycin in immature rats (3-4 weeks old) increases the severity of seizures induced by pilocarpine, including lengthening the total seizure duration and reducing the latency to the onset of seizures." | 3.78 | Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. ( Huang, X; Huang, Y; McMahon, J; Shin, D; Yang, J, 2012) |
| " We assessed the susceptibility to epilepsy after subthreshold dose of pilocarpine, as well as glial fibrillary acidic protein (GFAP) expression using immunohistochemistry." | 3.78 | Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine. ( Feng, B; Pan, XH; Sun, HL; Wang, CY; Xu, Y; Yang, LX; Zhang, SH; Zhang, SP; Zhong, K; Zhu, W, 2012) |
| " This "period without stimulus" was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150." | 3.77 | Early physical exercise and seizure susceptibility later in life. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Scorza, FA; Silva Araújo, BH, 2011) |
| "Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)." | 3.75 | Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 3.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| " In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy." | 3.72 | Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| " beta2(-/-) mice displayed increased susceptibility to seizures, as indicated by reduced latency and threshold for pilocarpine-induced seizures, but seemed normal in other neurological tests." | 3.71 | Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. ( Avery, C; Bharucha, V; Brown, A; Catterall, WA; Chen, C; Chen, Y; Gillespie, PJ; Isom, LL; Jones, D; Kazarinova-Noyes, K; Kazen-Gillespie, KA; Macdonald, RL; Malhotra, JD; Ransom, BR; Saunders, TL; Scheuer, T; Shrager, P; Westenbroek, RE, 2002) |
| "The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions." | 3.71 | Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide. ( Gulec, G; Noyan, B, 2001) |
| " In addition, both homozygous and heterozygous mutant mice are highly resistant to the seizures produced by systemic administration of the muscarinic agonist pilocarpine." | 3.69 | Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. ( Hamilton, SE; Hille, B; Idzerda, RL; Levey, AI; Loose, MD; McKnight, GS; Nathanson, NM; Qi, M, 1997) |
| "The severity of seizure induced by pilocarpine gradually increased, becoming significant at 28 days after CCI." | 1.62 | Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. ( Dohgu, S; Hashiguchi, K; Itoh, K; Kataoka, Y; Sakai, K; Takata, F; Tominaga, K; Yamanaka, G; Yamauchi, A; Yasunaga, M, 2021) |
| "Cortical dysplasia is the most common etiology of intractable epilepsy." | 1.48 | Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia. ( Feng, L; Wang, YL; Xiao, B; Yue, ZW, 2018) |
| "In rats with frequent severe seizures, we found a clear loss of Prox1 and NeuN expression in the dentate granule cell layer (GCL), which was confined mainly to the suprapyramidal blade of the GCL at the septal and middle regions of the septotemporal axis of the hippocampus." | 1.46 | Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus. ( Seki, T; Toda, K; Uemori, T, 2017) |
| "TRPC6 knockdown increased seizure susceptibility, excitability ratio and paired-pulse inhibition in the dentate gyrus (DG) of normal animals." | 1.42 | The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. ( Kang, TC; Kim, YJ, 2015) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| "Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function and susceptibility to arrhythmias have not been directly investigated." | 1.35 | Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. ( Bealer, SL; Little, JG; Metcalf, CS; Poelzing, S, 2009) |
| "Prolonged seizures in early childhood are associated with an increased risk of development of epilepsy in later life." | 1.32 | Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. ( Brooks-Kayal, AR; Hsu, FC; Raol, YS; Zhang, G, 2004) |
| "No overt motor seizures were observed in this age group." | 1.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 12 (36.36) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Sakai, K | 1 |
| Takata, F | 1 |
| Yamanaka, G | 1 |
| Yasunaga, M | 1 |
| Hashiguchi, K | 1 |
| Tominaga, K | 1 |
| Itoh, K | 1 |
| Kataoka, Y | 1 |
| Yamauchi, A | 1 |
| Dohgu, S | 1 |
| Sano, F | 1 |
| Shigetomi, E | 1 |
| Shinozaki, Y | 1 |
| Tsuzukiyama, H | 1 |
| Saito, K | 1 |
| Mikoshiba, K | 1 |
| Horiuchi, H | 1 |
| Cheung, DL | 1 |
| Nabekura, J | 1 |
| Sugita, K | 1 |
| Aihara, M | 1 |
| Koizumi, S | 1 |
| Uemori, T | 1 |
| Toda, K | 1 |
| Seki, T | 1 |
| Yue, ZW | 1 |
| Wang, YL | 1 |
| Xiao, B | 1 |
| Feng, L | 1 |
| Yin, P | 1 |
| Liu, J | 1 |
| Li, Z | 1 |
| Wang, YY | 1 |
| Qiao, NN | 1 |
| Huang, SY | 1 |
| Li, BM | 1 |
| Sun, RP | 1 |
| López-López, J | 1 |
| Jané Salas, E | 1 |
| Chimenos Küstner, E | 1 |
| Epps, SA | 1 |
| Kahn, AB | 1 |
| Holmes, PV | 1 |
| Boss-Williams, KA | 1 |
| Weiss, JM | 1 |
| Weinshenker, D | 1 |
| Kim, YJ | 1 |
| Kang, TC | 1 |
| Thyrion, L | 1 |
| Portelli, J | 2 |
| Raedt, R | 1 |
| Glorieux, G | 1 |
| Larsen, LE | 1 |
| Sprengers, M | 1 |
| Van Lysebettens, W | 1 |
| Carrette, E | 1 |
| Delbeke, J | 1 |
| Vonck, K | 1 |
| Boon, P | 1 |
| Trindade-Filho, EM | 1 |
| de Castro-Neto, EF | 1 |
| de A Carvalho, R | 1 |
| Lima, E | 1 |
| Scorza, FA | 2 |
| Amado, D | 1 |
| Naffah-Mazzacoratti, Mda G | 1 |
| Cavalheiro, EA | 4 |
| Blanco, MM | 1 |
| dos Santos, JG | 1 |
| Perez-Mendes, P | 1 |
| Kohek, SR | 1 |
| Cavarsan, CF | 1 |
| Hummel, M | 1 |
| Albuquerque, C | 1 |
| Mello, LE | 2 |
| Peternel, S | 1 |
| Pilipović, K | 1 |
| Zupan, G | 1 |
| Metcalf, CS | 1 |
| Poelzing, S | 1 |
| Little, JG | 1 |
| Bealer, SL | 1 |
| Gomes da Silva, S | 1 |
| de Almeida, AA | 1 |
| Silva Araújo, BH | 1 |
| Arida, RM | 1 |
| Bankstahl, M | 1 |
| Müller, CJ | 1 |
| Wilk, E | 1 |
| Schughart, K | 1 |
| Löscher, W | 1 |
| Huang, X | 1 |
| McMahon, J | 1 |
| Yang, J | 1 |
| Shin, D | 1 |
| Huang, Y | 1 |
| Thielemans, L | 1 |
| Ver Donck, L | 1 |
| Loyens, E | 1 |
| Coppens, J | 1 |
| Aourz, N | 1 |
| Aerssens, J | 1 |
| Vermoesen, K | 1 |
| Clinckers, R | 1 |
| Schallier, A | 1 |
| Michotte, Y | 1 |
| Moechars, D | 1 |
| Collingridge, GL | 1 |
| Bortolotto, ZA | 3 |
| Smolders, I | 1 |
| Zhu, W | 1 |
| Zhang, SH | 1 |
| Feng, B | 1 |
| Zhong, K | 1 |
| Yang, LX | 1 |
| Sun, HL | 1 |
| Zhang, SP | 1 |
| Xu, Y | 1 |
| Wang, CY | 1 |
| Pan, XH | 1 |
| Nehlig, A | 1 |
| Dubé, C | 1 |
| Koning, E | 1 |
| Chen, C | 1 |
| Bharucha, V | 1 |
| Chen, Y | 1 |
| Westenbroek, RE | 1 |
| Brown, A | 1 |
| Malhotra, JD | 1 |
| Jones, D | 1 |
| Avery, C | 1 |
| Gillespie, PJ | 1 |
| Kazen-Gillespie, KA | 1 |
| Kazarinova-Noyes, K | 1 |
| Shrager, P | 1 |
| Saunders, TL | 1 |
| Macdonald, RL | 1 |
| Ransom, BR | 1 |
| Scheuer, T | 1 |
| Catterall, WA | 1 |
| Isom, LL | 1 |
| Druga, R | 1 |
| Kubová, H | 1 |
| Suchomelová, L | 1 |
| Haugvicová, R | 1 |
| Setkowicz, Z | 1 |
| Janeczko, K | 1 |
| MEENA, AL | 1 |
| CONN, JH | 1 |
| NAUMANN, H | 1 |
| HARDY, JD | 1 |
| Zhang, G | 1 |
| Raol, YS | 1 |
| Hsu, FC | 1 |
| Brooks-Kayal, AR | 1 |
| Brenneke, F | 1 |
| Bukalo, O | 1 |
| Dityatev, A | 1 |
| Lie, AA | 1 |
| Choi, IS | 1 |
| Cho, JH | 1 |
| Lee, MG | 1 |
| Choi, BJ | 1 |
| Scharfman, HE | 1 |
| Goodman, JH | 1 |
| Rigoulot, MA | 1 |
| Berger, RE | 1 |
| Walling, SG | 1 |
| Mercurio, TC | 1 |
| Stormes, K | 1 |
| Maclusky, NJ | 1 |
| Guidine, PA | 1 |
| Rezende, GH | 1 |
| Queiroz, CM | 1 |
| Prado, VF | 1 |
| Prado, MA | 1 |
| Pereira, GS | 1 |
| Moraes, MF | 1 |
| Hamilton, SE | 1 |
| Loose, MD | 1 |
| Qi, M | 1 |
| Levey, AI | 1 |
| Hille, B | 1 |
| McKnight, GS | 1 |
| Idzerda, RL | 1 |
| Nathanson, NM | 1 |
| Gulec, G | 1 |
| Noyan, B | 1 |
| Heim, C | 1 |
| Sontag, KH | 1 |
| Meldrum, B | 1 |
| Millan, M | 1 |
| Patel, S | 1 |
| de Sarro, G | 1 |
| Silva, DF | 1 |
| Turski, WA | 1 |
| Calderazzo-Filho, LS | 1 |
| Turski, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.[NCT05585476] | 98 participants (Anticipated) | Interventional | 2022-12-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pilocarpine and Diathesis
| Article | Year |
|---|---|
[Prognosis and treatment of dry mouth. Systematic review].
Topics: Cholinergic Antagonists; Clinical Trials as Topic; Dental Caries; Disease Susceptibility; Double-Bli | 2014 |
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
31 other studies available for pilocarpine and Diathesis
| Article | Year |
|---|---|
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Susceptibility; Gene Expression; | 2021 |
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept | 2021 |
Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus.
Topics: Animals; Antigens, Nuclear; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Doublecor | 2017 |
Axon Initial Segment Structural Plasticity is Involved in Seizure Susceptibility in a Rat Model of Cortical Dysplasia.
Topics: Animals; Axon Initial Segment; Axons; Disease Models, Animal; Disease Susceptibility; Electroencepha | 2018 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.
Topics: Animals; Depression; Disease Models, Animal; Disease Susceptibility; Epilepsy; Galanin; Gene Express | 2013 |
The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus.
Topics: Animals; Calbindin 1; Dentate Gyrus; Disease Models, Animal; Disease Susceptibility; Excitatory Post | 2015 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Serotonin depletion effects on the pilocarpine model of epilepsy.
Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, | 2008 |
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept | 2009 |
Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Disease Susceptibility; Epilepsy, Temporal Lobe; Female; Glu | 2009 |
Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.
Topics: Aconitine; Actin Cytoskeleton; Action Potentials; Animals; Arrhythmias, Cardiac; Biomarkers; Blood P | 2009 |
Early physical exercise and seizure susceptibility later in life.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Disease Susceptibility; Epile | 2011 |
Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship | 2012 |
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Convulsants; Disease Susceptibility; Down-Regulation; I | 2012 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil | 2012 |
Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Brain; Disease Models, Animal; Diseas | 2012 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.
Topics: Action Potentials; Animals; Disease Susceptibility; Mice; Mice, Knockout; Nerve Fibers; Neural Condu | 2002 |
Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent.
Topics: Aging; Animals; Brain; Cerebral Cortex; Disease Susceptibility; Lithium; Pilocarpine; Rats; Status E | 2003 |
Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Disease Susceptibility; Drug Res | 2003 |
Pepsin in gastric physiology: effect of ulcer diathesis, ACTH, histamine, anesthesia-operation, banthine, pilocarpine, epinephrine, and sedation upon blood and urine pepsin levels and upon gastric acidity.
Topics: Adrenocorticotropic Hormone; Anesthesia; Disease Susceptibility; Enzyme Precursors; Epinephrine; Gas | 1957 |
Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility.
Topics: Amino Acid Transport System X-AG; Animals; Cell Separation; Convulsants; Dentate Gyrus; Disease Mode | 2004 |
Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Biomarkers; Calbindin 2; Cell Count; Convulsants; Disease Susceptibility; Elect | 2004 |
Pilocarpine-induced seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Disease Susceptibility; Female; Immunohistochemistry; Maternal Exposure; Methylazoxymethano | 2005 |
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Estrogens; Estrous Cycle; Fema | 2005 |
Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Knockout; Pilocarpine; Status E | 2008 |
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.
Topics: Animals; Behavior, Animal; Disease Susceptibility; Kainic Acid; Ligands; Mice; Mice, Knockout; Musca | 1997 |
Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Disease Models, Animal; Disease Progression; | 2001 |
Transient occlusion of rat carotid arteries decreases susceptibility to pilocarpine seizures.
Topics: Animals; Behavior, Animal; Carotid Arteries; Cerebrovascular Circulation; Constriction; Disease Susc | 1991 |
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
Topics: Aging; Animals; Behavior, Animal; Brain; Disease Susceptibility; Electroencephalography; Female; Mal | 1987 |