pilocarpine has been researched along with Depressive Disorder in 15 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 5.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "A rat model of epilepsy was established using lithium chloride." | 3.91 | Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. ( Dai, D; Fu, WL; Li, Y; Liu, J; Xu, XW; Yang, JZ; Zhu, HX, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| " We examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between TLE and depression, which developed in Wistar rats following pilocarpine status epilepticus (SE)." | 3.76 | Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2010) |
| " We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent with a depressive state: behavioral equivalents of anhedonia and despair, dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, and compromised raphe-hippocampal serotonergic transmission." | 3.76 | Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D, 2010) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 1.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| " It is concluded that in clinical dosage mianserin is devoid of effects upon muscarinic receptors, alpha 1 adrenoceptors and noradrenaline uptake in the pupil." | 1.27 | Failure of mianserin to affect autonomic function in the pupils of depressed patients. ( Checkley, S; Delgado, I; Shur, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wulsin, AC | 1 |
| Franco-Villanueva, A | 1 |
| Romancheck, C | 1 |
| Morano, RL | 1 |
| Smith, BL | 1 |
| Packard, BA | 1 |
| Danzer, SC | 1 |
| Herman, JP | 1 |
| Liu, J | 2 |
| Zhu, HX | 1 |
| Fu, WL | 1 |
| Xu, XW | 1 |
| Yang, JZ | 1 |
| Dai, D | 1 |
| Li, Y | 1 |
| Shen, Y | 1 |
| Peng, W | 1 |
| Chen, Q | 1 |
| Hammock, BD | 1 |
| Li, D | 1 |
| Yang, J | 1 |
| Ding, J | 2 |
| Wang, X | 2 |
| Peng, WF | 1 |
| Li, X | 1 |
| Fan, F | 1 |
| Zhang, QQ | 1 |
| Mazarati, AM | 2 |
| Pineda, E | 2 |
| Shin, D | 2 |
| Tio, D | 1 |
| Taylor, AN | 1 |
| Sankar, R | 2 |
| KURODA, I | 1 |
| Shur, E | 2 |
| Checkley, S | 2 |
| Delgado, I | 1 |
| Sitaram, N | 1 |
| Jones, D | 1 |
| Kelwala, S | 1 |
| Bell, J | 1 |
| Stevenson, J | 1 |
| Gershon, S | 1 |
| Lauriello, J | 1 |
| Kenny, WM | 1 |
| Sutton, L | 1 |
| Golshan, S | 1 |
| Ruiz, C | 1 |
| Kelsoe, J | 1 |
| Rapaport, M | 1 |
| Gillin, JC | 2 |
| Salah, RS | 1 |
| Cameron, OG | 1 |
| Sokolski, KN | 1 |
| Demet, EM | 1 |
| Seifritz, E | 1 |
| Rapaport, MH | 1 |
| Kelsoe, JR | 1 |
| Bhatti, T | 1 |
| Stahl, SM | 1 |
| Thompson, C | 1 |
| Checkley, SA | 1 |
1 trial available for pilocarpine and Depressive Disorder
| Article | Year |
|---|---|
Sleep electroencephalographic response to muscarinic and serotonin1A receptor probes in patients with major depression and in normal controls.
Topics: Adult; Depressive Disorder; Double-Blind Method; Down-Regulation; Electroencephalography; Female; Hu | 1998 |
14 other studies available for pilocarpine and Depressive Disorder
| Article | Year |
|---|---|
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Cognition Disorders; Depressive Disorder; Disease Mode | 2018 |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Comorbidity; Depressive Disorder; Disease | 2019 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.
Topics: Animals; Antigens, Nuclear; Chronic Disease; Depressive Disorder; Disease Models, Animal; Epilepsy; | 2016 |
Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Comorbidity; Convulsants; Depressive Disorder; Dis | 2010 |
Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
Topics: Animals; Convulsants; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocam | 2010 |
[Studies on the effects of whooping cough vaccine on the living body, especially experiments by means of electromyography of the respiratory muscles. III. Electromyogram of the intercostal muscles with administration of autonomic drugs after inoculation w
Topics: Autonomic Agents; Bordetella pertussis; Depression; Depressive Disorder; Electromyography; Humans; I | 1961 |
Failure of mianserin to affect autonomic function in the pupils of depressed patients.
Topics: Adult; Aged; Depressive Disorder; Dibenzazepines; Dose-Response Relationship, Drug; Female; Humans; | 1983 |
Pharmacology of the human iris: development and use of challenge strategies in the study of antidepression response.
Topics: Depressive Disorder; Humans; Iris; Phenylephrine; Pilocarpine; Receptors, Adrenergic, alpha; Recepto | 1983 |
Pupil studies in depressed patients: an investigation of the mechanism of action of desipramine.
Topics: Adult; Aged; Depressive Disorder; Desipramine; Drug Synergism; Female; Humans; Male; Middle Aged; Ph | 1982 |
The cholinergic REM sleep induction test with pilocarpine in mildly depressed patients and normal controls.
Topics: Adult; Analysis of Variance; Depressive Disorder; Electroencephalography; Female; Humans; Male; Midd | 1993 |
Pilocarpine for anticholinergic adverse effects associated with desipramine treatment.
Topics: Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Desipramine; Humans; Male; Midd | 1996 |
Increased pupillary sensitivity to pilocarpine in depression.
Topics: Adult; Depressive Disorder; Humans; Male; Middle Aged; Pilocarpine; Pupil | 1996 |
The effects of alaproclate on the pupillary responses to tyramine, phenylephrine and pilocarpine in depressed patients.
Topics: Alanine; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Phenylephrine; Pilocarpin | 1985 |