pilocarpine has been researched along with Depression in 19 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 7.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 7.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 5.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "The results of present study concluded that GBbf treatment suppressed lithium-pilocarpine induced spontaneous recurrent seizures severity and incidence with improved cognitive functions, reduced anxiety-like behavior and aggression." | 3.85 | Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 3.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| " An epilepsy model was induced in female rats by administration of pilocarpine." | 3.76 | Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures. ( Amado, D; Arganãraz, GA; Cavalheiro, EA; Frussa-Filho, R; Lima, DC; Naffah-Mazzacoratti, Mda G; Vale, TG; Varella, PP, 2010) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 3.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| "Comorbid depression is common in patients with epilepsy." | 1.48 | Different behavioral and pathological changes between epilepsy-associated depression and primary depression models. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2018) |
| "Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood." | 1.35 | Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009) |
| "Cycloheximide-treated animals differed from Pilo animals in the extent of hilar loss and supragranular mossy fiber sprouting as well as tissue shrinkage in the dorsal hippocampus." | 1.33 | Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy. ( Blanco, MM; Dos Santos, JG; Longo, BM; Mello, LE; Menezes de Oliveira, MG, 2005) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 1.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "Dental Caries are an uncommon, but significant side effect of the tricyclic antidepressants and other anticholinergic psychoactive drugs." | 1.26 | Rampant dental caries in the treatment of depression. ( Bassuk, E; Schoonover, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, S | 1 |
| Xin, Y | 1 |
| JiaWen, W | 1 |
| ShuQin, Z | 1 |
| GuiLian, Z | 1 |
| HaiQin, W | 1 |
| Zhen, G | 1 |
| HongWei, R | 1 |
| YongNan, L | 1 |
| Mazumder, AG | 1 |
| Sharma, P | 1 |
| Patial, V | 1 |
| Singh, D | 1 |
| Medel-Matus, JS | 2 |
| Shin, D | 4 |
| Sankar, R | 4 |
| Mazarati, A | 3 |
| Peng, WF | 1 |
| Fan, F | 1 |
| Li, X | 1 |
| Zhang, QQ | 1 |
| Ding, J | 2 |
| Wang, X | 2 |
| Shen, Y | 1 |
| Peng, W | 1 |
| Chen, Q | 1 |
| Hammock, BD | 1 |
| Liu, J | 1 |
| Li, D | 1 |
| Yang, J | 1 |
| Epps, SA | 1 |
| Kahn, AB | 1 |
| Holmes, PV | 1 |
| Boss-Williams, KA | 1 |
| Weiss, JM | 1 |
| Weinshenker, D | 1 |
| Small, KM | 1 |
| Nunes, E | 1 |
| Hughley, S | 1 |
| Addy, NA | 1 |
| Yang, H | 1 |
| Jung, S | 1 |
| Seo, J | 1 |
| Khalid, A | 1 |
| Yoo, JS | 1 |
| Park, J | 1 |
| Kim, S | 1 |
| Moon, J | 1 |
| Lee, ST | 1 |
| Jung, KH | 1 |
| Chu, K | 1 |
| Lee, SK | 1 |
| Jeon, D | 1 |
| Siddarth, P | 1 |
| Baldwin, RA | 1 |
| Caplan, R | 1 |
| Mazarati, AM | 1 |
| Kwon, YS | 1 |
| Bragin, A | 1 |
| Pineda, E | 1 |
| Tio, D | 1 |
| Taylor, AN | 1 |
| Lima, DC | 1 |
| Vale, TG | 1 |
| Arganãraz, GA | 1 |
| Varella, PP | 1 |
| Frussa-Filho, R | 1 |
| Cavalheiro, EA | 1 |
| Naffah-Mazzacoratti, Mda G | 1 |
| Amado, D | 1 |
| Pal, A | 1 |
| Nayak, S | 1 |
| Sahu, PK | 1 |
| Swain, T | 1 |
| KURODA, I | 1 |
| Dos Santos, JG | 1 |
| Longo, BM | 1 |
| Blanco, MM | 1 |
| Menezes de Oliveira, MG | 1 |
| Mello, LE | 1 |
| Kofman, O | 1 |
| Bersudsky, Y | 1 |
| Vinnitsky, I | 1 |
| Alpert, C | 1 |
| Belmaker, RH | 1 |
| Bassuk, E | 1 |
| Schoonover, S | 1 |
| Singh, V | 1 |
| Khanna, R | 1 |
| Srivastava, VK | 1 |
| Palit, G | 1 |
| Shanker, K | 1 |
| Gold, N | 1 |
19 other studies available for pilocarpine and Depression
| Article | Year |
|---|---|
The P2X7 receptor in activated microglia promotes depression- and anxiety-like behaviors in lithium -pilocarpine induced epileptic rats.
Topics: Animals; Anxiety; Depression; Lithium; Male; Microglia; Pilocarpine; Purinergic P2X Receptor Antagon | 2020 |
Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation.
Topics: Aggression; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain; Depression; Epilepsy, Tempor | 2017 |
Inherent vulnerabilities in monoaminergic pathways predict the emergence of depressive impairments in an animal model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Convulsants; Depression; Disease Models, Animal; Epil | 2017 |
Different behavioral and pathological changes between epilepsy-associated depression and primary depression models.
Topics: Animals; Depression; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Male; Pilocarp | 2018 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.
Topics: Animals; Depression; Disease Models, Animal; Disease Susceptibility; Epilepsy; Galanin; Gene Express | 2013 |
Ventral tegmental area muscarinic receptors modulate depression and anxiety-related behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cholinesterase Inhibitors; Depression; Food Preferences; Male; M | 2016 |
Altered behavior and neural activity in conspecific cagemates co-housed with mouse models of brain disorders.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Depression; Electroshock; Epilepsy, Temporal Lobe; Ex | 2016 |
Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depression; Disease Models, Animal; Drug Delive | 2017 |
Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.
Topics: Animals; Behavior, Animal; Depression; Epilepsy, Temporal Lobe; Fluoxetine; Hippocampus; Lithium Chl | 2008 |
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted | 2009 |
Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Epilepsy; Female; Male; Motor Activity; Pilocarpine; | 2010 |
Piperine protects epilepsy associated depression: a study on role of monoamines.
Topics: Alkaloids; Anhedonia; Animals; Anticonvulsants; Behavior, Animal; Benzodioxoles; Biogenic Monoamines | 2011 |
[Studies on the effects of whooping cough vaccine on the living body, especially experiments by means of electromyography of the respiratory muscles. III. Electromyogram of the intercostal muscles with administration of autonomic drugs after inoculation w
Topics: Autonomic Agents; Bordetella pertussis; Depression; Depressive Disorder; Electromyography; Humans; I | 1961 |
Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Cell Count; Conditioning, Psychological; C | 2005 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Sy | 1993 |
Rampant dental caries in the treatment of depression.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dental Caries; Depression; Drug Combinations | 1978 |
Synthesis and pharmacological evaluation of some phenothiazines as antidepressants.
Topics: Amphetamine; Animals; Antidepressive Agents; Depression; Drug Synergism; Female; Male; Mice; Nervous | 1992 |
Endogenous depression in general practice.
Topics: Antidepressive Agents; Depression; Family Practice; Humans; Pilocarpine | 1972 |