pilocarpine has been researched along with Dental Caries in 20 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Dental Caries: Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS." | 7.91 | The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study. ( Chen, TH; Chen, YC; Hsu, CY; Hung, KC; Ko, CH; Lin, CY; Lin, MS; Lin, YS, 2019) |
| "Propranolol was given in high (20 mg/kg/day) and low (10 mg/kg/day) doses via osmotic pumps." | 5.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| "Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS." | 3.91 | The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study. ( Chen, TH; Chen, YC; Hsu, CY; Hung, KC; Ko, CH; Lin, CY; Lin, MS; Lin, YS, 2019) |
| "We undermitted the patient the dental treatment of Sjogren's syndrome." | 2.47 | Scleroderma and CREST syndrome: a case report in dentistry. ( Baldoni, M; Bussolati, A; Lauritano, D; Leonida, A, 2011) |
| "The causes of xerostomia are numerous, of which the principal are, drug or radiation induced xerostomia and primary an secondary Sjögren's syndrome." | 2.41 | [Dry mouth]. ( Liozon, E; Soria, P; Vidal, E, 2001) |
| "Numerous regimens treat symptoms of xerostomia and associated caries and mucositis." | 2.40 | Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy. ( Garg, AK; Malo, M, 1997) |
| "Early detection and treatment of hyperglycemia and hyposalivation may provide a useful strategy for preventing the dental complications of diabetes and promoting oral health in this population." | 1.38 | Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice. ( Abboud-Werner, S; Chun, YH; Fajardo, R; Harris, SE; Horn, D; Jorgensen, J; Macdougall, M; Mohan, S; Yeh, CK, 2012) |
| "Pilocarpine hydrochloride was shown to have some beneficial effect on quality of life of these patients." | 1.34 | Prevention of oral and salivary gland impairment in irradiated adolescent patients with head and neck cancer: a suggested protocol. ( Aframian, DJ; Davidovich, E; Peretz, B, 2007) |
| "Treatment with pilocarpine hydrochloride may be beneficial in the case of impaired salivary function in patients treated with radioiodine." | 1.33 | Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer. ( Aframian, DJ; Helcer, M; Livni, D; Markitziu, A, 2006) |
| "Propranolol was given in high (20 mg/kg/day) and low (10 mg/kg/day) doses via osmotic pumps." | 1.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| " The findings provide further evidence that chronic administration of propranolol alters salivary composition by decreasing proline-rich proteins and concurrently enhances susceptibility to caries." | 1.28 | The effect of chronic propranolol treatment on salivary composition and caries in the rat. ( Bowen, WH; Falany, JL; Pearson, SK; Tabak, LA; Watson, GE, 1990) |
| "Dental Caries are an uncommon, but significant side effect of the tricyclic antidepressants and other anticholinergic psychoactive drugs." | 1.26 | Rampant dental caries in the treatment of depression. ( Bassuk, E; Schoonover, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsu, CY | 1 |
| Hung, KC | 1 |
| Lin, MS | 1 |
| Ko, CH | 1 |
| Lin, YS | 1 |
| Chen, TH | 1 |
| Lin, CY | 1 |
| Chen, YC | 1 |
| López-López, J | 1 |
| Jané Salas, E | 1 |
| Chimenos Küstner, E | 1 |
| Lauritano, D | 1 |
| Bussolati, A | 1 |
| Baldoni, M | 1 |
| Leonida, A | 1 |
| Yeh, CK | 1 |
| Harris, SE | 1 |
| Mohan, S | 1 |
| Horn, D | 1 |
| Fajardo, R | 1 |
| Chun, YH | 1 |
| Jorgensen, J | 1 |
| Macdougall, M | 1 |
| Abboud-Werner, S | 1 |
| Vissink, A | 1 |
| Burlage, FR | 1 |
| Spijkervet, FK | 1 |
| Jansma, J | 1 |
| Coppes, RP | 1 |
| MUHLER, JC | 2 |
| BIXLER, D | 2 |
| SHAFER, WG | 1 |
| Aframian, DJ | 2 |
| Helcer, M | 1 |
| Livni, D | 1 |
| Markitziu, A | 1 |
| Davidovich, E | 1 |
| Peretz, B | 1 |
| Shiboski, CH | 1 |
| Hodgson, TA | 1 |
| Ship, JA | 1 |
| Schiødt, M | 1 |
| O'Connell, AC | 2 |
| Pearson, SK | 3 |
| Bowen, WH | 3 |
| Van Wuyckhuyse, BC | 1 |
| Martínez-Gomis, J | 1 |
| Planas, ME | 1 |
| Planelles, X | 1 |
| Bartrons, R | 1 |
| Sánchez, S | 1 |
| Garg, AK | 1 |
| Malo, M | 1 |
| Vidal, E | 1 |
| Liozon, E | 1 |
| Soria, P | 1 |
| Atkinson, JC | 1 |
| Baum, BJ | 1 |
| Muzyka, BC | 1 |
| Bassuk, E | 1 |
| Schoonover, S | 1 |
| Leach, SA | 1 |
| Connell, R | 1 |
| Watson, GE | 1 |
| Falany, JL | 1 |
| Tabak, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.[NCT05585476] | 98 participants (Anticipated) | Interventional | 2022-12-31 | Not yet recruiting | |||
| Yeur-Hur Lai, PhD, RN, School of Nursing, College of Medicine, National Taiwan University[NCT03883152] | 131 participants (Actual) | Observational | 2017-06-27 | Completed | |||
| Xerostomy Treatment in Patients With Sjogren's Syndrome in Chile :A Double Blind Control Trial Comparing Orally Pilocarpine Drops and Artificial Saliva[NCT00438048] | Phase 4 | 76 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for pilocarpine and Dental Caries
| Article | Year |
|---|---|
[Prognosis and treatment of dry mouth. Systematic review].
Topics: Cholinergic Antagonists; Clinical Trials as Topic; Dental Caries; Disease Susceptibility; Double-Bli | 2014 |
Scleroderma and CREST syndrome: a case report in dentistry.
Topics: Aged; Combined Modality Therapy; CREST Syndrome; Deglutition Disorders; Dental Caries; Dentures; Dis | 2011 |
Prevention and treatment of the consequences of head and neck radiotherapy.
Topics: Anti-Bacterial Agents; Cranial Irradiation; Dental Caries; Dysgeusia; Head and Neck Neoplasms; Human | 2003 |
Management of salivary hypofunction during and after radiotherapy.
Topics: Amifostine; Dental Caries; Humans; Muscarinic Agonists; Pilocarpine; Radiation Injuries; Radiation-P | 2007 |
Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy.
Topics: Cariostatic Agents; Chronic Disease; Dental Caries; Fluorides; Gels; Head and Neck Neoplasms; Humans | 1997 |
[Dry mouth].
Topics: Candidiasis, Oral; Dental Caries; Diagnosis, Differential; Humans; Medical History Taking; Muscarini | 2001 |
14 other studies available for pilocarpine and Dental Caries
| Article | Year |
|---|---|
The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study.
Topics: Adult; Candidiasis; Dental Caries; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Outcome A | 2019 |
Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.
Topics: Amelogenin; Animals; Dental Caries; Dental Enamel Proteins; Diabetes Mellitus, Type 1; Female; Hyper | 2012 |
The effect of pilocarpine on dental caries in the rat.
Topics: Animals; Dental Caries; Pilocarpine; Rats | 1957 |
The effect of pilocarpine in single or divided daily doses on the incidence of dental caries in the rat.
Topics: Animals; Dental Caries; Incidence; Pilocarpine; Rats | 1958 |
Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer.
Topics: Adult; Aged; Blood Pressure; Body Temperature; Chronic Disease; Dental Caries; Female; Heart Rate; H | 2006 |
Prevention of oral and salivary gland impairment in irradiated adolescent patients with head and neck cancer: a suggested protocol.
Topics: Adolescent; Child; Clinical Protocols; Cranial Irradiation; Dental Caries; Head and Neck Neoplasms; | 2007 |
Pilocarpine alters caries development in partially-desalivated rats.
Topics: Analysis of Variance; Animals; Cariostatic Agents; Dental Caries; Female; Parotid Gland; Pilocarpine | 1994 |
The effect of propranolol on salivary gland function and dental caries development in young and aged rats.
Topics: Aging; Alveolar Bone Loss; Animals; Dental Caries; Dental Caries Susceptibility; Dental Plaque; Diet | 1993 |
Fluoride and pilocarpine reduce the risk of caries produced by chronic clomipramine treatment in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Cariostatic Agents; Cholinergic Antagonists; Cl | 1997 |
Salivary enhancement: current status and future therapies.
Topics: Animals; Aquaporin 1; Aquaporins; Blood Group Antigens; Cholinergic Agents; Cranial Irradiation; Den | 2001 |
Assessing salivary gland hypofunction--Part two.
Topics: Anti-Infective Agents, Local; Candidiasis, Oral; Dental Caries; Humans; Maltose; Mastication; Muscar | 2002 |
Rampant dental caries in the treatment of depression.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dental Caries; Depression; Drug Combinations | 1978 |
Reversal of fissure caries in the albino rat by stimulating salivary flow with pilocarpine.
Topics: Animals; Body Weight; Dental Caries; Dental Fissures; Diet, Cariogenic; Pilocarpine; Rats; Saliva; S | 1990 |
The effect of chronic propranolol treatment on salivary composition and caries in the rat.
Topics: Analysis of Variance; Animals; Dental Caries; Dental Caries Susceptibility; Female; Infusion Pumps; | 1990 |