pilocarpine has been researched along with Delayed Effects, Prenatal Exposure in 17 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine." | 7.72 | Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development. ( Janeczko, K; Kłak, K; Setkowicz, Z, 2003) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 5.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "To elucidate the impact of maternal seizures in the developing rat brain, pregnant Wistar rats were subjected to the pilocarpine-induced seizures and pups from different litters were studied at different ages." | 3.83 | Maternal seizures can affect the brain developing of offspring. ( Amado, D; Cossa, AC; da Graça Naffah-Mazzacoratti, M; da Silva Fernandes, MJ; de Alencar Rocha, AK; do Vale, TG; Lima, DC, 2016) |
| "To evaluate a potential insult in the cerebellum of pups exposed to maternal epileptic seizures during intrauterine life, female rats were subjected to pilocarpine-induced epilepsy." | 3.77 | Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures. ( Amado, D; Cavalheiro, EA; Cossa, AC; da Graça Naffah-Mazzacoratti, M; da Silva Fernandes, MJ; da Silva, IR; da Silva, JA; de Oliveira, EM; Higa, EM; Lima, DC; Perosa, SR, 2011) |
| " An epilepsy model was induced in female rats by administration of pilocarpine." | 3.76 | Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures. ( Amado, D; Arganãraz, GA; Cavalheiro, EA; Frussa-Filho, R; Lima, DC; Naffah-Mazzacoratti, Mda G; Vale, TG; Varella, PP, 2010) |
| "In the present study, we explored the consequences of epilepsy on the neurobehavioral development of the offspring in a rat model of spontaneous epilepsy, the lithium-pilocarpine model of temporal lobe epilepsy not dependent on genetic factors and in animals not receiving any antiepileptic treatment." | 3.75 | Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model. ( Boehrer, A; de Vasconcelos, AP; Desor, D; Nehlig, A; Raffo, E, 2009) |
| "To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine." | 3.72 | Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development. ( Janeczko, K; Kłak, K; Setkowicz, Z, 2003) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| "Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior." | 1.38 | Social behavior impairment in offspring exposed to maternal seizures in utero. ( Amado, D; Cysneiros, RM; Novaes, GF; Scorza, FA, 2012) |
| "Pilocarpine was administered on postnatal day 25 and mortality rates were measured after 2 and 24h." | 1.37 | Prenatal exposure to restraint or predator stresses attenuates field excitatory postsynaptic potentials in infant rats. ( Ahmadzadeh, R; Roshan-Milani, S; Saboory, E, 2011) |
| "We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring." | 1.36 | Seizures during pregnancy modify the development of hippocampal interneurons of the offspring. ( Amado, D; Cabral, FR; Cavalheiro, EA; Cossa, AC; da Silva, AV; de Lima, E; de Oliveira, EM; do Vale, TG; Lima, DC; Naffah-Mazzacoratti, Mda G; Torres, LB, 2010) |
| "Motor manifestations of seizure activity were observed continuously for 6 hours and rated." | 1.33 | Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data. ( Janeczko, K; Janicka, D; Jasiński, A; Majcher, K; Setkowicz, Z; Skórka, T; Sułek, Z, 2006) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nejatbakhsh, M | 1 |
| Saboory, E | 4 |
| Bagheri, M | 1 |
| Yin, P | 1 |
| Liu, J | 1 |
| Li, Z | 1 |
| Wang, YY | 1 |
| Qiao, NN | 1 |
| Huang, SY | 1 |
| Li, BM | 1 |
| Sun, RP | 1 |
| Pourmotabbed, A | 1 |
| Mahmoodi, G | 1 |
| Mahmoodi, S | 1 |
| Mohammadi-Farani, A | 1 |
| Nedaei, SE | 1 |
| Pourmotabbed, T | 2 |
| Cossa, AC | 3 |
| Lima, DC | 4 |
| do Vale, TG | 2 |
| de Alencar Rocha, AK | 1 |
| da Graça Naffah-Mazzacoratti, M | 2 |
| da Silva Fernandes, MJ | 2 |
| Amado, D | 5 |
| Raffo, E | 1 |
| de Vasconcelos, AP | 1 |
| Boehrer, A | 1 |
| Desor, D | 1 |
| Nehlig, A | 1 |
| Vale, TG | 1 |
| Arganãraz, GA | 1 |
| Varella, PP | 1 |
| Frussa-Filho, R | 1 |
| Cavalheiro, EA | 3 |
| Naffah-Mazzacoratti, Mda G | 2 |
| Sadaghiani, MM | 1 |
| da Silva, AV | 1 |
| de Lima, E | 1 |
| Torres, LB | 1 |
| de Oliveira, EM | 2 |
| Cabral, FR | 1 |
| Ahmadzadeh, R | 2 |
| Roshan-Milani, S | 2 |
| Pilehvarian, AA | 1 |
| Perosa, SR | 1 |
| da Silva, JA | 1 |
| da Silva, IR | 1 |
| Higa, EM | 1 |
| Novaes, GF | 1 |
| Scorza, FA | 1 |
| Cysneiros, RM | 1 |
| Setkowicz, Z | 2 |
| Kłak, K | 1 |
| Janeczko, K | 2 |
| Majcher, K | 1 |
| Janicka, D | 1 |
| Sułek, Z | 1 |
| Skórka, T | 1 |
| Jasiński, A | 1 |
| St-Pierre, LS | 1 |
| Parker, GH | 1 |
| Bubenik, GA | 1 |
| Persinger, MA | 1 |
| Yang, Y | 1 |
| Liu, Z | 1 |
| Cermak, JM | 1 |
| Tandon, P | 1 |
| Sarkisian, MR | 1 |
| Stafstrom, CE | 1 |
| Neill, JC | 1 |
| Blusztajn, JK | 1 |
| Holmes, GL | 1 |
| Watanabe, T | 1 |
| Matsuhashi, K | 1 |
| Takayama, S | 1 |
17 other studies available for pilocarpine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Effect of prenatal stress on ɑ5 GABA
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Gene Expression Regulation, Developmental | 2018 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Musca | 2014 |
Maternal seizures can affect the brain developing of offspring.
Topics: Animals; bcl-2-Associated X Protein; Blood Glucose; Female; Hippocampus; Male; Pilocarpine; Poly (AD | 2016 |
Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model.
Topics: Age Factors; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Body Weight; Chi-Squ | 2009 |
Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Epilepsy; Female; Male; Motor Activity; Pilocarpine; | 2010 |
Prenatal stress potentiates pilocarpine-induced epileptic behaviors in infant rats both time and sex dependently.
Topics: Analysis of Variance; Animals; Animals, Newborn; Corticosterone; Disease Models, Animal; Epilepsy; F | 2010 |
Seizures during pregnancy modify the development of hippocampal interneurons of the offspring.
Topics: Age Factors; Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Count; Disease Models, Animal | 2010 |
Predator and restraint stress during gestation facilitates pilocarpine-induced seizures in prepubertal rats.
Topics: Animals; Animals, Newborn; Cats; Cholinergic Agents; Corticosterone; Female; Male; Pilocarpine; Pred | 2011 |
Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures.
Topics: Animals; Animals, Newborn; Cerebellum; Epilepsy; Female; Glial Fibrillary Acidic Protein; Globins; H | 2011 |
Prenatal exposure to restraint or predator stresses attenuates field excitatory postsynaptic potentials in infant rats.
Topics: Animals; Corticosterone; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Gestational | 2011 |
Social behavior impairment in offspring exposed to maternal seizures in utero.
Topics: Animals; Anxiety; Convulsants; Epilepsy, Tonic-Clonic; Female; Male; Pilocarpine; Pregnancy; Pregnan | 2012 |
Long-term changes in postnatal susceptibility to pilocarpine-induced seizures in rats exposed to gamma radiation at different stages of prenatal development.
Topics: Animals; Animals, Newborn; Brain; Female; Gamma Rays; Male; Pilocarpine; Pregnancy; Prenatal Exposur | 2003 |
Brains with different degrees of dysplasia show different patterns of neurodegenerative changes following pilocarpine-induced seizures. Histologic evidence of tissue damage correlated with MRI data.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Female; Gestational Age; Magnetic R | 2006 |
Enhanced mortality of rat pups following inductions of epileptic seizures after perinatal exposures to 5 nT, 7 Hz magnetic fields.
Topics: Animals; Convulsants; Death, Sudden; Electromagnetic Fields; Female; Hippocampus; Lithium; Nitric Ox | 2007 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
[Study on the postnatal neuro-behavioral development in rats treated prenatally with drugs acting on the autonomic nervous systems].
Topics: Animals; Atropine; Autonomic Agents; Central Nervous System Diseases; Chlorpromazine; Epinephrine; F | 1985 |