pilocarpine has been researched along with Convulsive Generalized Seizure Disorder in 10 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 8.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 4.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| "Anti-seizure drugs are the most commonly employed treatment option for epilepsy and these generally provide effective management of seizures." | 1.42 | Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats. ( Pilitsis, JG; Shin, DS; Smith, AB; Yu, W, 2015) |
| "In all age groups, the dosage of DZP that stopped the seizures at 5 min was not effective in terminating seizures at 60 min." | 1.32 | Diazepam terminates brief but not prolonged seizures in young, naïve rats. ( Goodkin, HP; Holmes, GL; Liu, X, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mallmann, MP | 1 |
| Mello, FK | 1 |
| Neuberger, B | 1 |
| da Costa Sobral, KG | 1 |
| Fighera, MR | 1 |
| Royes, LFF | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Bo-Qiang, L | 1 |
| Si-Tong, Z | 1 |
| Zu-Yuan, L | 1 |
| Wan-Yun, N | 1 |
| Bin, C | 1 |
| Yuan, L | 1 |
| Xuyun, L | 1 |
| Liangen, M | 1 |
| You-Chao, C | 1 |
| Xin-Zhen, Y | 1 |
| Zhong, C | 1 |
| Xiao-Ying, Y | 1 |
| Wei-Wei, H | 1 |
| Sonoda, EY | 1 |
| Cysneiros, RM | 1 |
| Arida, RM | 1 |
| Cavalheiro, EA | 2 |
| Scorza, FA | 1 |
| Yu, W | 1 |
| Smith, AB | 1 |
| Pilitsis, JG | 1 |
| Shin, DS | 1 |
| Valente, SG | 1 |
| Marques, RH | 1 |
| Baracat, EC | 1 |
| Naffah-Mazzacoratti, MG | 1 |
| Amado, D | 1 |
| Zhao, S | 1 |
| Aviles, ER | 1 |
| Fujikawa, DG | 1 |
| Goodkin, HP | 1 |
| Liu, X | 1 |
| Holmes, GL | 1 |
| Yang, J | 1 |
| Woodhall, GL | 1 |
| Jones, RS | 1 |
| Engelhorn, T | 1 |
| Hufnagel, A | 1 |
| Weise, J | 1 |
| Baehr, M | 1 |
| Doerfler, A | 1 |
| al-Tajir, G | 1 |
| Starr, MS | 1 |
10 other studies available for pilocarpine and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Generalized; Hippocampus; Pilocarpin | 2022 |
Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.
Topics: Animals; Anticonvulsants; Convulsants; Cyclohexenes; Dose-Response Relationship, Drug; Drug Compound | 2018 |
Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure.
Topics: Animals; Disease Models, Animal; Epilepsy, Generalized; Male; Muscarinic Agonists; Neurons; Pilocarp | 2013 |
Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats.
Topics: Animals; Anticonvulsants; Epilepsy, Generalized; Hippocampus; Male; Pilocarpine; Rats, Sprague-Dawle | 2015 |
Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model.
Topics: Animals; Epilepsy, Generalized; Estradiol; Estrus; Female; Gonadal Steroid Hormones; Hippocampus; Ho | 2008 |
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Topics: Analysis of Variance; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Cathepsin D | 2010 |
Diazepam terminates brief but not prolonged seizures in young, naïve rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; | 2003 |
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Exci | 2006 |
Monitoring of acute generalized status epilepticus using multilocal diffusion MR imaging: early prediction of regional neuronal damage.
Topics: Acute Disease; Animals; Brain; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Dise | 2007 |
Disordered dopamine neurotransmission in the striatum of rats undergoing pilocarpine-induced generalized seizures, as revealed by microdialysis.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Chromatography, Hi | 1993 |