pilocarpine has been researched along with Cognitive Decline in 14 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the correlations among cognitive impairment, MFS, seizure frequency and drug resistance in a rat model of epilepsy induced by lithium-pilocarpine." | 8.02 | Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine. ( Huang, Y; Li, Y; Luo, X; Ren, S; Wang, L; Wu, G; Wu, J; Wu, Q, 2021) |
| "We investigated the correlations among cognitive impairment, MFS, seizure frequency and drug resistance in a rat model of epilepsy induced by lithium-pilocarpine." | 4.02 | Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine. ( Huang, Y; Li, Y; Luo, X; Ren, S; Wang, L; Wu, G; Wu, J; Wu, Q, 2021) |
| "Association of ROS production during seizure period was further confirmed by histopathological studies revealing loss of normal neuronal cells in hippocampus region." | 1.56 | Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice. ( Abbirami, E; Ruckmani, K; Sivasudha, T; Smilin Bell Aseervatham, G, 2020) |
| "Temporal lobe epilepsy is associated with significant structural pathology in the hippocampus." | 1.51 | Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction. ( Coulter, DA; Kahn, JB; Port, RG; Takano, H; Yue, C, 2019) |
| "Seizures were induced by intraperitoneal injection of pilocarpine (25mg/kg) in male rats." | 1.46 | Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. ( Choi, BY; Choi, HC; Kho, AR; Kim, JH; Lee, SH; Sohn, M; Song, HK; Suh, SW, 2017) |
| "Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available." | 1.46 | Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis. ( Liang, LP; Patel, M; Pearson, JN; Roberts, LJ; Warren, E, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, J | 1 |
| Wang, L | 1 |
| Huang, Y | 1 |
| Wu, Q | 1 |
| Luo, X | 2 |
| Li, Y | 1 |
| Ren, S | 1 |
| Wu, G | 1 |
| Xiang, T | 1 |
| Zeng, C | 1 |
| Li, S | 2 |
| Ma, M | 1 |
| Wu, Y | 1 |
| Dyomina, AV | 1 |
| Smolensky, IV | 1 |
| Zaitsev, AV | 2 |
| Smilin Bell Aseervatham, G | 1 |
| Abbirami, E | 1 |
| Sivasudha, T | 1 |
| Ruckmani, K | 1 |
| Xing, J | 1 |
| Han, D | 1 |
| Xu, D | 1 |
| Li, X | 1 |
| Sun, L | 1 |
| Ohgomori, T | 1 |
| Jinno, S | 1 |
| Cai, Q | 1 |
| Gan, J | 1 |
| Luo, R | 1 |
| Qu, Y | 1 |
| Wan, C | 1 |
| Mu, D | 1 |
| Fan, Z | 2 |
| Feng, X | 1 |
| Zhu, X | 1 |
| Yin, S | 1 |
| Zamudio, SR | 1 |
| Pichardo-Macías, LA | 1 |
| Díaz-Villegas, V | 1 |
| Flores-Navarrete, IL | 1 |
| Guzmán-Velázquez, S | 1 |
| Kahn, JB | 1 |
| Port, RG | 1 |
| Yue, C | 1 |
| Takano, H | 1 |
| Coulter, DA | 1 |
| Mayer, T | 1 |
| Kopitz, J | 1 |
| Plaschke, K | 1 |
| Weiss, J | 1 |
| Seidling, HM | 1 |
| Haefeli, WE | 1 |
| Lee, SH | 1 |
| Choi, BY | 1 |
| Kim, JH | 1 |
| Kho, AR | 1 |
| Sohn, M | 1 |
| Song, HK | 1 |
| Choi, HC | 1 |
| Suh, SW | 1 |
| Kalemenev, SV | 1 |
| Zubareva, OE | 1 |
| Sizov, VV | 1 |
| Lavrent'eva, VV | 1 |
| Lukomskaya, NY | 1 |
| Kim, KK | 1 |
| Magazanik, LG | 1 |
| Pearson, JN | 1 |
| Warren, E | 1 |
| Liang, LP | 1 |
| Roberts, LJ | 1 |
| Patel, M | 1 |
14 other studies available for pilocarpine and Cognitive Decline
| Article | Year |
|---|---|
Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine.
Topics: Animals; Cognitive Dysfunction; Epilepsy; Humans; Lithium; Mossy Fibers, Hippocampal; Pilocarpine; R | 2021 |
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Convulsants; Epilepsy, Temporal Lobe; Ferroptosis; Gen | 2021 |
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe | 2023 |
Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.
Topics: Animals; Cognitive Dysfunction; Dose-Response Relationship, Drug; Fruit; Male; Mice; Oxidative Stres | 2020 |
CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage.
Topics: Animals; Apoptosis; Brain; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Disea | 2019 |
Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Lipopolysaccharides; Locomotion; Male; Mice; | 2020 |
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Topics: Amygdala; Animals; Biomarkers; Brain Injuries; Cognitive Dysfunction; Lithium; Male; Necrosis; Neuro | 2017 |
Immunotherapy by targeting of VGKC complex for seizure control and prevention of cognitive impairment in a mouse model of epilepsy.
Topics: Animals; Antibodies; Cognitive Dysfunction; Disease Models, Animal; Humans; Immunotherapy; Lithium; | 2018 |
Subchronic cerebrolysin treatment alleviates cognitive impairments and dendritic arborization alterations of granular neurons in the hippocampal dentate gyrus of rats with temporal lobe epilepsy.
Topics: Amino Acids; Animals; Cognition; Cognitive Dysfunction; Dentate Gyrus; Epilepsy, Temporal Lobe; Hipp | 2019 |
Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction.
Topics: Animals; Cognitive Dysfunction; Dentate Gyrus; Epilepsy, Temporal Lobe; Female; Male; Mice, Inbred C | 2019 |
Limitations of the Anticholinergic Activity Assay and Assay-Based Anticholinergic Drug Scales.
Topics: Amitriptyline; Cholinergic Antagonists; Cognitive Dysfunction; Diphenhydramine; Dose-Response Relati | 2016 |
Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment.
Topics: Animals; Blood-Brain Barrier; Cell Death; Choline O-Acetyltransferase; Cognition; Cognitive Dysfunct | 2017 |
Memantine attenuates cognitive impairments after status epilepticus induced in a lithium-pilocarpine model.
Topics: Animals; Cognition; Cognitive Dysfunction; Exploratory Behavior; Extinction, Psychological; Lithium; | 2016 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal | 2017 |