pilocarpine has been researched along with Cognition Disorders in 30 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 7.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 7.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 5.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 5.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies." | 3.88 | Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. ( Canzian, JM; Duarte, MMMF; Duarte, T; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS, 2018) |
| " In this study, the mice were injected with methylazoxymethanol acetate (MAM) both before and after pilocarpine-induced status epilepticus (SE) to achieve an overall ablation of newborn cells contributing to the pathological recruitment." | 3.88 | Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice. ( Feng, GF; Hu, M; Li, CJ; Liu, JX; Liu, Y; Xu, JH; Yuan, B; Zhu, K, 2018) |
| "The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen in human temporal lobe epilepsy." | 3.79 | Are morphologic and functional consequences of status epilepticus in infant rats progressive? ( Kubová, H; Mareš, P, 2013) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 3.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| "Here we investigated the effects of electroacupuncture over the cognitive deficits in the pilocarpine model of epilepsy in rats." | 3.73 | Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats. ( Blanco, MM; de Oliveira Freire, A; do Monte, FH; Dos Santos, JG; Mello, LE; Tabosa, A, 2005) |
| " In this study, immature rats were exposed to status epilepticus (SE) followed by a series of 25 flurothyl-induced seizures, SE alone, 25 flurothyl-induced seizures alone, or no seizures." | 3.72 | Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis". ( Hoffmann, AF; Holmes, GL; Zhao, Q, 2004) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 3.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 1.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Meanwhile, cerebral edema, as well as neuronal loss, was decreased in several brain areas in the GBC group." | 1.46 | Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. ( Gu, Y; Hu, Y; Huang, H; Huang, K; Ji, Z; Lin, Z; Pan, S; Wang, S; Wu, Y; Yang, T, 2017) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| " Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin." | 1.37 | Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. ( Tawfik, MK, 2011) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 1.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 21 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, Z | 1 |
| Huang, H | 1 |
| Gu, Y | 1 |
| Huang, K | 1 |
| Hu, Y | 1 |
| Ji, Z | 1 |
| Wu, Y | 1 |
| Wang, S | 1 |
| Yang, T | 1 |
| Pan, S | 1 |
| Oliveira, CV | 2 |
| Grigoletto, J | 2 |
| Canzian, JM | 1 |
| Duarte, MMMF | 1 |
| Duarte, T | 1 |
| Furian, AF | 2 |
| Oliveira, MS | 2 |
| Zhu, K | 1 |
| Yuan, B | 1 |
| Hu, M | 1 |
| Li, CJ | 1 |
| Xu, JH | 1 |
| Feng, GF | 1 |
| Liu, Y | 2 |
| Liu, JX | 1 |
| Wulsin, AC | 1 |
| Franco-Villanueva, A | 1 |
| Romancheck, C | 1 |
| Morano, RL | 1 |
| Smith, BL | 1 |
| Packard, BA | 1 |
| Danzer, SC | 1 |
| Herman, JP | 1 |
| Mohammad, H | 1 |
| Sekar, S | 1 |
| Wei, Z | 1 |
| Moien-Afshari, F | 1 |
| Taghibiglou, C | 1 |
| Jia, R | 1 |
| Jia, N | 1 |
| Yang, F | 1 |
| Liu, Z | 1 |
| Li, R | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Wang, L | 1 |
| Zhang, S | 1 |
| Zhang, Z | 1 |
| Zhang, H | 1 |
| Wu, S | 1 |
| Gao, F | 1 |
| Jiang, W | 1 |
| Klatte, K | 1 |
| Kirschstein, T | 1 |
| Otte, D | 1 |
| Pothmann, L | 1 |
| Müller, L | 1 |
| Tokay, T | 1 |
| Kober, M | 1 |
| Uebachs, M | 1 |
| Zimmer, A | 1 |
| Beck, H | 1 |
| Titiz, AS | 1 |
| Mahoney, JM | 1 |
| Testorf, ME | 1 |
| Holmes, GL | 3 |
| Scott, RC | 2 |
| Ahmad, M | 1 |
| Abu-Taweel, GM | 1 |
| Aboshaiqah, AE | 1 |
| Ajarem, JS | 1 |
| Funck, VR | 1 |
| Ribeiro, LR | 1 |
| Royes, LF | 1 |
| Fighera, MR | 1 |
| Cho, KO | 1 |
| Lybrand, ZR | 1 |
| Ito, N | 1 |
| Brulet, R | 1 |
| Tafacory, F | 1 |
| Zhang, L | 1 |
| Good, L | 1 |
| Ure, K | 1 |
| Kernie, SG | 1 |
| Birnbaum, SG | 1 |
| Scharfman, HE | 1 |
| Eisch, AJ | 1 |
| Hsieh, J | 1 |
| Pearson, JN | 1 |
| Rowley, S | 1 |
| Liang, LP | 1 |
| White, AM | 1 |
| Day, BJ | 1 |
| Patel, M | 1 |
| Li, T | 2 |
| Zhai, X | 1 |
| Jiang, J | 1 |
| Song, X | 2 |
| Han, W | 2 |
| Ma, J | 1 |
| Xie, L | 2 |
| Cheng, L | 2 |
| Chen, H | 2 |
| Jiang, L | 2 |
| He, R | 1 |
| Jun, Y | 1 |
| JiangTao, X | 1 |
| YuanGui, H | 1 |
| YongBin, S | 1 |
| Jun, Z | 1 |
| XiaoJun, M | 1 |
| JianChun, X | 1 |
| Heng, X | 1 |
| XiaoXin, Z | 1 |
| XinXiang, X | 1 |
| Müller, CJ | 1 |
| Gröticke, I | 1 |
| Bankstahl, M | 1 |
| Löscher, W | 1 |
| Kleen, JK | 1 |
| Lenck-Santini, PP | 1 |
| Zhang, Y | 1 |
| Wang, W | 1 |
| Sun, Z | 1 |
| Feng, D | 1 |
| Deng, Y | 1 |
| Zhao, G | 1 |
| Wang, H | 1 |
| Huang, Y | 1 |
| Venturin, GT | 1 |
| Greggio, S | 1 |
| Marinowic, DR | 1 |
| Zanirati, G | 1 |
| Cammarota, M | 1 |
| Machado, DC | 1 |
| DaCosta, JC | 1 |
| Hong, S | 1 |
| Xin, Y | 1 |
| HaiQin, W | 1 |
| GuiLian, Z | 1 |
| Ru, Z | 1 |
| ShuQin, Z | 1 |
| HuQing, W | 1 |
| Li, Y | 1 |
| Yun, D | 1 |
| Tawfik, MK | 1 |
| Shaltiel, G | 1 |
| Hanan, M | 1 |
| Wolf, Y | 1 |
| Barbash, S | 1 |
| Kovalev, E | 1 |
| Shoham, S | 1 |
| Soreq, H | 1 |
| Kubová, H | 2 |
| Mareš, P | 2 |
| Suchomelová, L | 1 |
| Brozek, G | 1 |
| Druga, R | 1 |
| Pitkänen, A | 1 |
| Hoffmann, AF | 1 |
| Zhao, Q | 1 |
| Dos Santos, JG | 1 |
| Tabosa, A | 1 |
| do Monte, FH | 1 |
| Blanco, MM | 1 |
| de Oliveira Freire, A | 1 |
| Mello, LE | 1 |
| Ikegaya, Y | 1 |
| Nishiyama, N | 1 |
| Matsuki, N | 1 |
| Naranjo, CA | 1 |
| Fourie, J | 1 |
| Herrmann, N | 1 |
| Lanctôt, KL | 1 |
| Birt, C | 1 |
| Yau, KK | 1 |
| Huang, LT | 1 |
| Liou, CW | 1 |
| Yang, SN | 1 |
| Lai, MC | 1 |
| Hung, PL | 1 |
| Wang, TJ | 1 |
| Cheng, SC | 1 |
| Wu, CL | 1 |
| Fisher, A | 1 |
| Brandeis, R | 1 |
| Karton, I | 1 |
| Pittel, Z | 1 |
| Gurwitz, D | 1 |
| Haring, R | 1 |
| Sapir, M | 1 |
| Levy, A | 1 |
| Heldman, E | 1 |
1 trial available for pilocarpine and Cognition Disorders
| Article | Year |
|---|---|
Probing peripheral and central cholinergic system responses.
Topics: Adolescent; Adult; Age Factors; Aged; Cognition Disorders; Double-Blind Method; Female; Humans; Iris | 2000 |
29 other studies available for pilocarpine and Cognition Disorders
| Article | Year |
|---|---|
Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cognition Disorders; Disease Models, Animal; Gene | 2017 |
Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cerebral Cortex; Cognition Disorders; Convulsants; | 2018 |
Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Doublec | 2018 |
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Cognition Disorders; Depressive Disorder; Disease Mode | 2018 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; | 2019 |
Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.
Topics: Allosteric Regulation; Animals; Binding Sites; Cognition Disorders; D-Amino-Acid Oxidase; Disease Mo | 2013 |
Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Cognition Disorders; Comorbidity; Disease Model | 2014 |
The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus.
Topics: Animals; Cognition Disorders; Lithium Compounds; Male; Oxidative Stress; Pentoxifylline; Pilocarpine | 2014 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognition Disorders; Disease Models, Animal; | 2015 |
Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy.
Topics: Animals; Antioxidants; Cell Death; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal L | 2015 |
Intraperitoneal injection of IL-4/IFN-γ modulates the proportions of microglial phenotypes and improves epilepsy outcomes in a pilocarpine model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Brain; Cognition Disorders; Disease Models, Animal; Epilepsy; Immunologic | 2017 |
VEGF regulates hippocampal neurogenesis and reverses cognitive deficits in immature rats after status epilepticus through the VEGF R2 signaling pathway.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Neuroge | 2017 |
Erythropoietin pre-treatment prevents cognitive impairments following status epilepticus in rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Assoc | 2009 |
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Animals; Anxiety Disorders; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Epileps | 2009 |
Hippocampal interictal spikes disrupt cognition in rats.
Topics: Animals; Cognition Disorders; Conditioning, Operant; Confidence Intervals; Electroencephalography; E | 2010 |
Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cognition Disorders; Granulocyte Colony-S | 2010 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Astrocytes; Benzamides; Cell Count; Cognition Disorders; Disease Mode | 2012 |
Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Catalase; Cognition Disorders; D | 2011 |
Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.
Topics: 3' Untranslated Regions; Acetylcholinesterase; Animals; Binding Sites; Cells, Cultured; Cognition; C | 2013 |
Are morphologic and functional consequences of status epilepticus in infant rats progressive?
Topics: Aggression; Aging; Animals; Animals, Newborn; Antimanic Agents; Atrophy; Behavior, Animal; Brain; Ce | 2013 |
Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis.
Topics: Age Factors; Animals; Behavior, Animal; Body Weight; Brain; Cognition Disorders; Electroencephalogra | 2004 |
Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis".
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Death; Cognition Disorders; | 2004 |
Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats.
Topics: Animals; Cognition Disorders; Electroacupuncture; Epilepsy; Male; Maze Learning; Pilocarpine; Rats; | 2005 |
L-type Ca(2+) channel blocker inhibits mossy fiber sprouting and cognitive deficits following pilocarpine seizures in immature mice.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cogn | 2000 |
Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Topics: Aging; Aminophylline; Animals; Cell Differentiation; Cognition Disorders; Growth Cones; Hippocampus; | 2002 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; D | 1991 |