pilocarpine has been researched along with Chronic Illness in 145 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Timoptol Ophthalmic Solution (timolol maleate, MSD) is a topical beta-adrenergic receptor blokking agent which lowers elevated intraocular pressure when applied once or twice daily." | 9.04 | [Efficacy and safety of long-term maintenance treatment with timolol ophthalmic solution in chronic open-angle glaucoma (author's transl)]. ( Katz, IM, 1979) |
| "Following a seventeen weeks study including 110 patients with open-angle glaucoma, 81,8% of the patients treated by timolol, administered twice a day, had a satisfactory control of their intraocular pressure, against only 41,8% of those patients treated by pilocarpine, administered four times a day." | 9.04 | [Results of a double-blind study comparing the effects of timolol and pilocarpine in 110 patients with chronic open-angle glaucoma]. ( Chagnon, A; Hamard, H; Ourgaud, AG; Plane, C; Sole, P; Vidal, R, 1978) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "To analyze the survival and the changes of proportions of Calbindin, Calretinin and Parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of Pilocarpine-induced epilepsy." | 7.79 | [Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy]. ( Liu, J; Liu, Y; Tang, F, 2013) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 7.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 7.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 7.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 7.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| " Oral pilocarpine (Salagen(R)), 30 mg/day, can ameliorate cGVHD-induced xerostomia and improve the flow rate from the major salivary glands." | 7.71 | The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease. ( Nagler, A; Nagler, RM, 2001) |
| "Our research studies transitory myopia induced by Pilocarpine treatment in glaucoma patients." | 7.70 | [A myopia study of glaucoma patients following pilocarpine instillation]. ( Ban, C; Hanciu, D; Petroi, C; Pop, I, 2000) |
| "Systemic administration of pilocarpine, which results in status epilepticus followed by recurrent seizures in rats, is a widely used experimental model of chronic limbic epilepsy." | 7.70 | Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat. ( Amado, D; Bentivoglio, M; Cavalheiro, EA; Correia, L, 1998) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 7.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| "Eight patients with chronic open-angle glaucoma who had an intraocular pressure greater than 24 mm Hg at some time during the day while taking timolol 0." | 7.67 | Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%. ( Binkowitz, B; Maclure, GM; Sturm, A; Vogel, R, 1989) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 5.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 5.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "As pilocarpine hydrochloride has been shown to relieve xerostomia in other disease categories, we administered pilocarpine hydrochloride 30 mg/day to six cGVHD patients and measured their whole saliva, parotid and submandibular-sublingual flow rates in both resting and stimulated conditions." | 5.30 | Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. ( Nagler, A; Nagler, RM, 1999) |
| "The aim of the present prospective masked study was to assess the effect of bimatoprost monotherapy on ocular blood flow and intraocular pressure (IOP) in eyes of primary chronic angle closure glaucoma patients already on concomitant timolol and pilocarpine." | 5.10 | Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma. ( Agarwal, HC; Gupta, V; Sihota, R, 2003) |
| "Following a seventeen weeks study including 110 patients with open-angle glaucoma, 81,8% of the patients treated by timolol, administered twice a day, had a satisfactory control of their intraocular pressure, against only 41,8% of those patients treated by pilocarpine, administered four times a day." | 5.04 | [Results of a double-blind study comparing the effects of timolol and pilocarpine in 110 patients with chronic open-angle glaucoma]. ( Chagnon, A; Hamard, H; Ourgaud, AG; Plane, C; Sole, P; Vidal, R, 1978) |
| "Timoptol Ophthalmic Solution (timolol maleate, MSD) is a topical beta-adrenergic receptor blokking agent which lowers elevated intraocular pressure when applied once or twice daily." | 5.04 | [Efficacy and safety of long-term maintenance treatment with timolol ophthalmic solution in chronic open-angle glaucoma (author's transl)]. ( Katz, IM, 1979) |
| " Eighty-two patients with glaucoma who had been prescribed pilocarpine eye drops three times daily to prevent visual loss were randomised into two groups." | 5.04 | Improving medication compliance: a randomised clinical trial. ( Norell, SE, 1979) |
| "Morris water maze test was used to evaluate learning and memory deficits in pilocarpine-induced chronic epilepsy rats 12 weeks after status epilepticus." | 3.88 | Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [ ( Cheng, DF; Ding, J; Shi, HC; Si, Z; Wang, X; Wu, XQ; Zhao, YN, 2018) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "Lithium chloride-pilocarpine-induced rats with status epilepticus (SE) were established." | 3.80 | Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. ( Du, Y; Liu, W; Shi, R; Yang, W; Yu, W; Zhao, N; Zou, Y, 2014) |
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| " A similar profusion of immature GABAergic cells was seen in rats with pilocarpine-induced chronic epilepsy." | 3.80 | Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation. ( DeFranco, DB; Di Maio, R; Kanuparthi, PS; Samarasinghe, RA; Timothy Greenamyre, J, 2014) |
| "To analyze the survival and the changes of proportions of Calbindin, Calretinin and Parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of Pilocarpine-induced epilepsy." | 3.79 | [Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy]. ( Liu, J; Liu, Y; Tang, F, 2013) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 3.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| "Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats." | 3.77 | Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. ( Cox, CB; Ermolinsky, BS; Farrell, B; Garrido-Sanabria, ER; Nair, S; Pacheco, LF; Ruiz, N, 2011) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 3.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| "Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients." | 3.76 | Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 3.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| " To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS." | 3.73 | Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide. ( Longo, B; Mello, LE; Vezzani, A, 2005) |
| " In the present study, chronically epileptic rats had their brains processed for neo-Timm and acetylcholinesterase two months after the induction of status epilepticus with pilocarpine." | 3.73 | Neo-Timm staining in the thalamus of chronically epileptic rats. ( Hamani, C; Mello, LE; Paulo, Id, 2005) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 3.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| "A pilocarpine-induced SRS model of epilepsy affords a reliable model of epileptogenesis suitable for evaluating new chemical entities as putative antiepileptogenics." | 3.72 | Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models. ( Lyon, A; Marone, S; Wainman, D; Weaver, DF, 2004) |
| "For half of the animals (nine of 17) subject to pilocarpine-induced status epilepticus (SE), when assessed 60 days later, variable levels of reactive astrocytes were seen in many thalamic, hippocampal, amygdalar, and neocortical areas." | 3.71 | Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy. ( Garzillo, CL; Mello, LE, 2002) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine (PILO) in rats, we investigated the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as well as the hydroperoxide (HPx) concentration in the hippocampus of rats during status epilepticus (SE), silent and chronic periods." | 3.71 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats. ( Abdalla, DS; Amado, D; Bellissimo, MI; Cavalheiro, EA; Ferreira, EC; Naffah-Mazzacoratti, MG, 2001) |
| " Oral pilocarpine (Salagen(R)), 30 mg/day, can ameliorate cGVHD-induced xerostomia and improve the flow rate from the major salivary glands." | 3.71 | The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease. ( Nagler, A; Nagler, RM, 2001) |
| "Our research studies transitory myopia induced by Pilocarpine treatment in glaucoma patients." | 3.70 | [A myopia study of glaucoma patients following pilocarpine instillation]. ( Ban, C; Hanciu, D; Petroi, C; Pop, I, 2000) |
| "Systemic administration of pilocarpine, which results in status epilepticus followed by recurrent seizures in rats, is a widely used experimental model of chronic limbic epilepsy." | 3.70 | Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat. ( Amado, D; Bentivoglio, M; Cavalheiro, EA; Correia, L, 1998) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 3.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| "The capacity of the microcirculation in the liposclerotic skin of patients with chronic venous insufficiency to vasodilate in response to pilocarpine electrophoresis was assessed using laser Doppler fluxmetry." | 3.68 | Hyperaemic response in the skin microcirculation of patients with chronic venous insufficiency. ( Cheatle, TR; Chittenden, SJ; Coleridge Smith, PD; Scurr, JH; Shami, SK, 1993) |
| "Eight patients with chronic open-angle glaucoma who had an intraocular pressure greater than 24 mm Hg at some time during the day while taking timolol 0." | 3.67 | Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%. ( Binkowitz, B; Maclure, GM; Sturm, A; Vogel, R, 1989) |
| "A study on the diagnostic value of the parotid and mixed saliva assay after stimulation with 1% pilocarpine hydrochloride was carried out in 36 controls and 26 patients affected with chronic pancreatitis." | 3.66 | Study of parotid and mixed saliva in the diagnosis of chronic pancreatitis. ( Bonoldi, MC; Dobrilla, G; Felder, M; Filippini, M; Gaspa, U; Moroder, E; Schnabl, D; Valentini, M, 1979) |
| "Saliva secretion was studied via pilocarpine test in 40 patients with pancreas exocrine insufficiency: 32 patients with chronic pancreatitis and 8 patients with pancreas carcinoma." | 3.66 | [Changes in salivary secretion in pancreatic patients]. ( Ivanov, L; Mendizova, A, 1981) |
| "In order to study the disposition which is thought to be latent in chronic pancreatitis, we investigated the sweat chloride concentration of 95 normal subjects, 43 cases of chronic pancreatitis, 12 cases of cholelithiasis, 15 cases of peptic ulcers, 16 cases of hepatic diseases and 23 cases of diabetes mellitus with the sweat test, using the method of pilocarpine iontophoresis." | 3.66 | The significance of the sweat test in chronic pancreatitis. ( Endo, K; Hanawa, M; Koizumi, M; Takahashi, S; Takebe, T, 1978) |
| "A total of 360 patients with open angle glaucoma were included; they were defined as those who had intraocular pressure greater than 21 mm Hg while receiving single, topical antiglaucoma therapy." | 2.67 | Timolol-pilocarpine fixed-ratio combinations in the treatment of chronic open angle glaucoma. A controlled multicenter study of 48 weeks. Scandinavian Timpilo Study Group. ( Puustjärvi, TJ; Repo, LP, 1992) |
| " For timolol, nasolacrimal occlusion collapsed the dose-response curve and extended the duration of action." | 2.67 | Therapeutic index of pilocarpine, carbachol, and timolol with nasolacrimal occlusion. ( Fuqua, M; Nardin, GF; Sharir, M; Zimmerman, TJ, 1992) |
| "Cystic fibrosis is a genetic recessive disorder caused by mutations in the gene that encodes the CFTR protein." | 2.41 | [Diagnosis of cystic fibrosis in adults]. ( Chinet, T; Fajac, I; Ferec, C; Garcia Carmona, T; Nguyen-Khoa, T, 2000) |
| "Numerous regimens treat symptoms of xerostomia and associated caries and mucositis." | 2.40 | Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy. ( Garg, AK; Malo, M, 1997) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 1.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus." | 1.40 | Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. ( Griesbach, G; Jentsch, JD; Mazarati, A; Pineda, E; Sankar, R; Shin, D, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 1.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "ACh-induced seizure-like events could be completely blocked by the non-specific muscarinic antagonist, atropine, and were partially blocked by the muscarinic-1 receptor antagonist, pirenzepine; but were not affected by the non-specific nicotinic antagonist, mecamylamine." | 1.35 | Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. ( Behrens, CJ; Friedman, A; Gross, M; Heinemann, U; Ivens, S; Njunting, M; Soreq, H; Tolner, E; Tolner, EA; Zimmerman, G, 2008) |
| "Treatment with pilocarpine hydrochloride may be beneficial in the case of impaired salivary function in patients treated with radioiodine." | 1.33 | Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer. ( Aframian, DJ; Helcer, M; Livni, D; Markitziu, A, 2006) |
| " In contrast, in human neocortical preparations obtained from epilepsy surgery, in approximately 20% of the slices spontaneous epileptiform activity appeared with this bicuculline dosage without SDs." | 1.32 | Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue. ( Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H, 2003) |
| "Oral pilocarpine was able to reduce and normalize the elevated levels of Na, Mg, TP, Alb, EGF, IgG, and IgA salivary concentrations at both resting and stimulated conditions." | 1.32 | Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged study. ( Nagler, A; Nagler, RM, 2003) |
| "As pilocarpine hydrochloride has been shown to relieve xerostomia in other disease categories, we administered pilocarpine hydrochloride 30 mg/day to six cGVHD patients and measured their whole saliva, parotid and submandibular-sublingual flow rates in both resting and stimulated conditions." | 1.30 | Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. ( Nagler, A; Nagler, RM, 1999) |
| "20 patients with open angle glaucoma or ocular hypertension and an elevated intraocular pressure (IOP) over 21 mmHg and without prior oral CAI-treatment were included in this study." | 1.30 | Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility. ( Barisani, T; Baumgartner, I; Biowski, R; Hommer, A; Kaminski, S; Koyuncu, D, 1998) |
| "Pilocarpine is a well established topical agent, but suffers troublesome sequelae, the most apparent of which is pupillary constriction." | 1.29 | The effect of pilocarpine on the glaucomatous visual field. ( Canning, CR; Elkington, AR; Luff, AJ; Webster, AR, 1993) |
| "In this paper two cases of Adie's syndrome are discussed." | 1.26 | [Observations in two cases of Adie's syndrome (author's transl)]. ( Pasco, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (32.41) | 18.7374 |
| 1990's | 27 (18.62) | 18.2507 |
| 2000's | 36 (24.83) | 29.6817 |
| 2010's | 33 (22.76) | 24.3611 |
| 2020's | 2 (1.38) | 2.80 |
| Authors | Studies |
|---|---|
| Owen, B | 1 |
| Bichler, E | 1 |
| Benveniste, M | 1 |
| Wang, X | 4 |
| Zhang, Y | 1 |
| Cheng, W | 1 |
| Gao, Y | 1 |
| Li, S | 1 |
| Pitsch, J | 1 |
| Becker, AJ | 1 |
| Schoch, S | 1 |
| Müller, JA | 1 |
| de Curtis, M | 1 |
| Gnatkovsky, V | 1 |
| Liu, TT | 1 |
| Feng, L | 1 |
| Liu, HF | 1 |
| Shu, Y | 1 |
| Xiao, B | 1 |
| Bittencourt, S | 1 |
| Ferrazoli, E | 1 |
| Valente, MF | 1 |
| Romariz, S | 1 |
| Janisset, NRLL | 1 |
| Macedo, CE | 1 |
| Antonio, BB | 1 |
| Barros, V | 1 |
| Mundim, M | 1 |
| Porcionatto, M | 1 |
| Aarão, MC | 1 |
| Miranda, MF | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Longo, BM | 2 |
| Mello, LE | 9 |
| Lim, JA | 1 |
| Moon, J | 1 |
| Kim, TJ | 1 |
| Jun, JS | 1 |
| Park, B | 1 |
| Byun, JI | 1 |
| Sunwoo, JS | 1 |
| Park, KI | 1 |
| Lee, ST | 1 |
| Jung, KH | 1 |
| Jung, KY | 1 |
| Kim, M | 1 |
| Jeon, D | 1 |
| Chu, K | 1 |
| Lee, SK | 1 |
| Wu, XQ | 1 |
| Zhao, YN | 1 |
| Ding, J | 2 |
| Si, Z | 1 |
| Cheng, DF | 1 |
| Shi, HC | 1 |
| Liu, J | 1 |
| Liu, Y | 2 |
| Tang, F | 1 |
| Pineda, E | 1 |
| Jentsch, JD | 1 |
| Shin, D | 1 |
| Griesbach, G | 1 |
| Sankar, R | 1 |
| Mazarati, A | 1 |
| Liu, W | 1 |
| Shi, R | 1 |
| Yang, W | 1 |
| Zhao, N | 1 |
| Du, Y | 1 |
| Zou, Y | 1 |
| Yu, W | 1 |
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Papageorgiou, IE | 1 |
| Fetani, AF | 1 |
| Lewen, A | 1 |
| Heinemann, U | 3 |
| Kann, O | 2 |
| Shrot, S | 1 |
| Ramaty, E | 1 |
| Biala, Y | 1 |
| Bar-Klein, G | 1 |
| Daninos, M | 1 |
| Kamintsky, L | 1 |
| Makarovsky, I | 1 |
| Statlender, L | 1 |
| Rosman, Y | 1 |
| Krivoy, A | 1 |
| Lavon, O | 1 |
| Kassirer, M | 1 |
| Friedman, A | 2 |
| Yaari, Y | 1 |
| Li, J | 1 |
| Jiang, G | 1 |
| Chen, Y | 1 |
| Chen, L | 1 |
| Li, Z | 2 |
| Wang, Z | 1 |
| Samarasinghe, RA | 1 |
| Kanuparthi, PS | 1 |
| Timothy Greenamyre, J | 1 |
| DeFranco, DB | 1 |
| Di Maio, R | 1 |
| Wei, D | 1 |
| Yang, F | 2 |
| Wang, Y | 1 |
| Wu, C | 2 |
| Wu, SX | 1 |
| Jiang, W | 1 |
| Zanirati, G | 2 |
| Azevedo, PN | 1 |
| Marinowic, DR | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Xerostomy Treatment in Patients With Sjogren's Syndrome in Chile :A Double Blind Control Trial Comparing Orally Pilocarpine Drops and Artificial Saliva[NCT00438048] | Phase 4 | 76 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pilocarpine and Chronic Illness
| Article | Year |
|---|---|
Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy.
Topics: Cariostatic Agents; Chronic Disease; Dental Caries; Fluorides; Gels; Head and Neck Neoplasms; Humans | 1997 |
[New therapeutic strategies for xerostomia in chronic graft versus host disease patients].
Topics: Animals; Chronic Disease; Cytokines; Graft vs Host Disease; Humans; Muscarinic Agonists; Pilocarpine | 2000 |
[Diagnosis of cystic fibrosis in adults].
Topics: Adolescent; Adult; Age Factors; Chlorides; Chronic Disease; Cystic Fibrosis; Cystic Fibrosis Transme | 2000 |
15 trials available for pilocarpine and Chronic Illness
| Article | Year |
|---|---|
Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Aged; Amides; Bimatoprost; Chronic Disease; Cl | 2003 |
Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma.
Topics: Aged; Chronic Disease; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure | 1994 |
Pilocarpine hydrochloride for symptomatic relief of xerostomia due to chronic graft-versus-host disease or total-body irradiation after bone-marrow transplantation for hematologic malignancies.
Topics: Bone Marrow Transplantation; Chronic Disease; Graft vs Host Disease; Hematologic Neoplasms; Humans; | 1997 |
Prepared association of metipranolol 0.1% + pilocarpine 2% and of timolol 0.5% + pilocarpine 2%. Comparison of clinical efficacy and topical tolerability in the treatment of patients affected by POAG tonometrically uncontrolled with beta-blocker alone (tw
Topics: Administration, Topical; Adrenergic beta-Antagonists; Blood Pressure; Chronic Disease; Drug Therapy, | 1997 |
Clinical use of a topical carbonic anhydrase inhibitor in patients affected by chronic simple glaucoma.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Carbonic Anhydrase Inhibitors; Chronic Disease | 1998 |
[Results of a double-blind study comparing the effects of timolol and pilocarpine in 110 patients with chronic open-angle glaucoma].
Topics: Aged; Chronic Disease; Clinical Trials as Topic; Glaucoma; Humans; Middle Aged; Pilocarpine; Propano | 1978 |
Management of chronic glaucoma with pilocarpine Ocuserts.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Female; Glaucom | 1977 |
[Efficacy and safety of long-term maintenance treatment with timolol ophthalmic solution in chronic open-angle glaucoma (author's transl)].
Topics: Aphakia, Postcataract; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, | 1979 |
Improving medication compliance: a randomised clinical trial.
Topics: Aged; Chronic Disease; Drug Administration Schedule; Female; Glaucoma; Humans; Male; Middle Aged; Pa | 1979 |
Timolol-pilocarpine fixed-ratio combinations in the treatment of chronic open angle glaucoma. A controlled multicenter study of 48 weeks. Scandinavian Timpilo Study Group.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Combinations; Female; Glaucoma, Open-Angle; Hu | 1992 |
Therapeutic index of pilocarpine, carbachol, and timolol with nasolacrimal occlusion.
Topics: Absorption; Carbachol; Chronic Disease; Cornea; Dose-Response Relationship, Drug; Double-Blind Metho | 1992 |
A prospective study of oral Nadolol in the management of patients with newly diagnosed chronic simple glaucoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Chronic Disease; Female; Glaucoma, Open-Angle; Humans | 1991 |
Primary therapy for chronic simple glaucoma the role of argon laser trabeculoplasty.
Topics: Aged; Chronic Disease; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Methods; M | 1985 |
[Influence of clonidine on intraocular pressure and pupillary diameter].
Topics: Analysis of Variance; Chronic Disease; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic | 1972 |
Guanethidine in chronic simple glaucoma.
Topics: Chronic Disease; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; Glaucoma; Guan | 1971 |
127 other studies available for pilocarpine and Chronic Illness
| Article | Year |
|---|---|
Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses.
Topics: Animals; CA1 Region, Hippocampal; Chronic Disease; Disease Progression; Epilepsy; Excitatory Postsyn | 2021 |
Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy.
Topics: Animals; Chronic Disease; Convulsants; Epilepsy; Excitatory Postsynaptic Potentials; Gene Expression | 2021 |
Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Circadian Rhythm; Cluster Analysis; Disease Models, Animal; Electroencepha | 2017 |
Altered axon initial segment in hippocampal newborn neurons, associated with recurrence of temporal lobe epilepsy in rats.
Topics: Animals; Axon Initial Segment; Behavior, Animal; Cell Proliferation; Chronic Disease; Dendrites; Den | 2017 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Mi | 2018 |
Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [
Topics: Acholeplasmataceae; Animals; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Fluorodeoxygl | 2018 |
[Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy].
Topics: Animals; Calbindin 2; Calbindins; Cell Survival; Chronic Disease; Epilepsy; gamma-Aminobutyric Acid; | 2013 |
Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavioral Symptoms; Brain; Chronic Disease; | 2014 |
Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chronic Disease; Disease Models, A | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; CD11b Antigen; Cell Count; Chronic Disease; | 2015 |
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Diseas | 2014 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; GABAergic Neurons; Gap Junctions; Glutam | 2014 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Transplantation of bone marrow mononuclear cells modulates hippocampal expression of growth factors in chronically epileptic animals.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chronic Disease; Disease Models, Animal; Ep | 2015 |
Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis.
Topics: Adenocarcinoma, Follicular; Adult; Aged; Carcinoma; Carcinoma, Papillary; Chronic Disease; Female; H | 2015 |
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencep | 2015 |
N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.
Topics: Animals; Antigens, Nuclear; Chronic Disease; Depressive Disorder; Disease Models, Animal; Epilepsy; | 2016 |
Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats.
Topics: Animals; Chronic Disease; Circadian Rhythm; Epilepsy; Gene Expression Regulation; Hippocampus; Male; | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A | 2016 |
Characterization of Intracranial Pressure Behavior in Chronic Epileptic Animals: A Preliminary Study.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Tempor | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Residual neurogenesis in chronically epileptic hippocampus of mice.
Topics: Animals; Bromodeoxyuridine; Cell Movement; Chronic Disease; Disease Models, Animal; Epilepsy; Female | 2016 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain; Chronic Disease; Convulsants; Cyclopropanes; Epi | 2008 |
Serotonin depletion effects on the pilocarpine model of epilepsy.
Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, | 2008 |
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Topics: Animals; Cerebral Cortex; Chronic Disease; Convulsants; Cyclic AMP-Dependent Protein Kinases; Diseas | 2009 |
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Choroid Plexus; Chronic Dis | 2010 |
Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine.
Topics: Animals; Catalase; Chronic Disease; Epilepsy; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxida | 2009 |
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1 | 2010 |
Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Post | 2010 |
Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats.
Topics: Age Factors; Animals; Chronic Disease; Dendrites; Dentate Gyrus; Disease Models, Animal; Male; Maze | 2010 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
Impaired mitochondrial biogenesis in hippocampi of rats with chronic seizures.
Topics: Animals; Chronic Disease; Disease Models, Animal; DNA, Mitochondrial; Down-Regulation; Epilepsy; Hip | 2011 |
Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.
Topics: Abdominal Fat; Analysis of Variance; Animals; Chronic Disease; Disease Models, Animal; Energy Metabo | 2011 |
Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Electrophysiology; Epilepsy, Temporal Lobe; Hippocampus; Im | 2011 |
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Excitatory Amino Acid Transporter 2; Hippocampus; Male; Mice; Mice, Transg | 2012 |
Seizure-induced 5-HT release and chronic impairment of serotonergic function in rats.
Topics: Acute Disease; Animals; Brain; Chronic Disease; Electroencephalography; Epilepsy; Hippocampus; Hydro | 2013 |
Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Brain; Chronic Disease; Convulsants; Gliosis; Male; Pilocarpine; Rats; Rats, Wi | 2002 |
Electrophysiologic abnormalities of the hippocampus in the pilocarpine/cycloheximide model of chronic spontaneous seizures.
Topics: Animals; Chronic Disease; Cycloheximide; Electrophysiology; Hippocampus; Male; Muscarinic Agonists; | 2002 |
Relations between brain pathology and temporal lobe epilepsy.
Topics: Animals; Brain; Cell Death; Cell Survival; Chronic Disease; Disease Models, Animal; Disease Progress | 2002 |
Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged study.
Topics: Adolescent; Adult; Albumins; Cations; Chronic Disease; Epidermal Growth Factor; Female; Follow-Up St | 2003 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; D | 2003 |
Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Hematoma, Subdur | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response | 2005 |
Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans.
Topics: Adult; Animals; Chronic Disease; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Fluorescent | 2005 |
Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide.
Topics: Animals; Chronic Disease; Cycloheximide; Densitometry; Dentate Gyrus; Disease Models, Animal; GAP-43 | 2005 |
Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats.
Topics: Afferent Pathways; Animals; Cell Differentiation; Cell Line; Cells, Cultured; Chronic Disease; Denta | 2005 |
Neo-Timm staining in the thalamus of chronically epileptic rats.
Topics: Acetylcholinesterase; Animals; Brain Mapping; Chronic Disease; Male; Nerve Endings; Pilocarpine; Rat | 2005 |
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Exci | 2006 |
Septo-hippocampal networks in chronically epileptic rats: potential antiepileptic effects of theta rhythm generation.
Topics: Action Potentials; Animals; Anticonvulsants; Biological Clocks; Chronic Disease; Drug Delivery Syste | 2006 |
Pro-epileptic effect of alfentanil in rats subjected to pilocarpine-induced chronic epilepsy.
Topics: Alfentanil; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Dose-Response Rela | 2006 |
Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer.
Topics: Adult; Aged; Blood Pressure; Body Temperature; Chronic Disease; Dental Caries; Female; Heart Rate; H | 2006 |
Abnormal mGluR2/3 expression in the perforant path termination zones and mossy fibers of chronically epileptic rats.
Topics: Animals; Chronic Disease; Dentate Gyrus; Down-Regulation; Epilepsy, Temporal Lobe; Fluorescent Antib | 2006 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chronic Disease; Convulsants; Disease Models, Animal; Down- | 2008 |
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Topics: Acetylcholine; Acetylcholinesterase; Alternative Splicing; Animals; Chronic Disease; Convulsants; El | 2008 |
The use of aceclydine in the treatment of glaucoma. Its effect on intraocular pressure and facility of aqueous humor outflow as compared to that of pilocarpine.
Topics: Anesthetics, Local; Aqueous Humor; Chronic Disease; Glaucoma; Humans; Intraocular Pressure; Miotics; | 1967 |
Chronic paroxysmal hemicrania. IX. On the mechanism of attack-related sweating.
Topics: Adult; Aged; Chronic Disease; Female; Forehead; Hot Temperature; Humans; Middle Aged; Migraine Disor | 1983 |
Chronic paroxysmal hemicrania: salivation, tearing and nasal secretion.
Topics: Adult; Aged; Autonomic Nervous System; Chronic Disease; Female; Functional Laterality; Humans; Middl | 1984 |
[Changes in salivary secretion in pancreatic patients].
Topics: Cholecystokinin; Chronic Disease; Female; Humans; Male; Middle Aged; Pancreas; Pancreatic Juice; Pan | 1981 |
Drugs and surgery in the treatment of glaucoma.
Topics: Chronic Disease; Ciliary Body; Glaucoma; Humans; Iris; Pilocarpine | 1980 |
[Observations in two cases of Adie's syndrome (author's transl)].
Topics: Accommodation, Ocular; Adie Syndrome; Adult; Chronic Disease; Diagnosis, Differential; Female; Human | 1980 |
Primary chronic angle-closure glaucoma in Chinese--a clinical exploration of its pathogenesis and natural course.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Anthropometry; Chronic Disease; Female; Glaucoma, | 1994 |
Clinical experience with a fixed dose combination therapy of timolol and pilocarpine used twice daily in the management of chronic open angle glaucoma.
Topics: Aged; Aged, 80 and over; Chronic Disease; Drug Administration Schedule; Drug Combinations; Female; G | 1994 |
Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Electrophysiology; Evoked Potentials; Hippocampus; In Vit | 1994 |
Timolol-pilocarpine fixed-ratio combinations in the treatment of chronic open angle glaucoma.
Topics: Chronic Disease; Drug Combinations; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Ophthal | 1993 |
Patient selection in the Timpilo Study.
Topics: Chronic Disease; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Opht | 1993 |
The effect of pilocarpine on the glaucomatous visual field.
Topics: Aged; Aged, 80 and over; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; M | 1993 |
[The interrelationship of the catecholamine and protein content of the tissue of the submandibular salivary glands and the mucosa during the secretory cycle in chronic inflammation of the oral soft tissues].
Topics: Animals; Carrageenan; Catecholamines; Chronic Disease; Female; Male; Mouth Mucosa; Pilocarpine; Rats | 1993 |
Hyperaemic response in the skin microcirculation of patients with chronic venous insufficiency.
Topics: Aged; Chronic Disease; Electrophoresis; Female; Humans; Hyperemia; Laser-Doppler Flowmetry; Male; Mi | 1993 |
Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats.
Topics: Animals; Antibody Specificity; Benzoxazines; Chronic Disease; Circadian Rhythm; Coloring Agents; Epi | 1996 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Topics: Adenosine Triphosphatases; Analysis of Variance; Animals; Cerebral Cortex; Chronic Disease; Drug Adm | 1997 |
Ocular hypotensive effect of pilocarpine before and after argon laser trabeculoplasty.
Topics: Aged; Aged, 80 and over; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure | 1997 |
Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility.
Topics: Administration, Topical; Aged; Carbonic Anhydrase Inhibitors; Cell Count; Chronic Disease; Cornea; D | 1998 |
Ocular tension and pupil diameter effects of timolol 0.50% and pilocarpine 2% or 4% in association.
Topics: Adrenergic beta-Antagonists; Aged; Chronic Disease; Drug Therapy, Combination; Female; Follow-Up Stu | 1997 |
[Tearing in a patient with glaucoma].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Chronic Disease; Female; Glaucoma, Open-Angle | 1998 |
Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat.
Topics: Animals; Antibodies; Atrophy; Cholinergic Fibers; Chronic Disease; Epilepsy; Hippocampus; Male; Neur | 1998 |
Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Chronic Disease; Female; Graft vs Host Disease; Huma | 1999 |
Loss of NADPH diaphorase-positive neurons in the hippocampal formation of chronic pilocarpine-epileptic rats.
Topics: Animals; Biomarkers; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epil | 1999 |
Chronic progressive ocular cicatrization.
Topics: Aged; Chronic Disease; Disease Progression; Eyelid Diseases; Humans; Male; Pemphigoid, Benign Mucous | 2000 |
[A myopia study of glaucoma patients following pilocarpine instillation].
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Male; Middle | 2000 |
[Chronic reflex cough in Ross's syndrome].
Topics: Adult; Chronic Disease; Cough; Female; Humans; Miotics; Pilocarpine; Reflex, Abnormal; Syndrome; Ton | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyru | 2001 |
The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease.
Topics: Administration, Oral; Albumins; Calcium; Chronic Disease; Epidermal Growth Factor; Graft vs Host Dis | 2001 |
Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats.
Topics: Animals; Chronic Disease; Epilepsy; Glutathione Peroxidase; Hippocampus; Hydrogen Peroxide; Male; Mu | 2001 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus.
Topics: Animals; Cell Respiration; Cells, Cultured; Chronic Disease; DNA, Mitochondrial; Down-Regulation; El | 2002 |
Peripheral iridectomy for chronic simple glaucoma with narrow angles.
Topics: Aged; Anterior Chamber; Chronic Disease; Glaucoma; Humans; Intraocular Pressure; Iris; Male; Pilocar | 1979 |
Study of parotid and mixed saliva in the diagnosis of chronic pancreatitis.
Topics: Amylases; Bicarbonates; Cholecystokinin; Chronic Disease; Humans; Pancreas; Pancreatitis; Parotid Gl | 1979 |
The significance of the sweat test in chronic pancreatitis.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Chronic Disease; Cystic Fibrosis; Eating; Female; Human | 1978 |
[Comparative study of timolol and pilocarpine in chronic glaucoma].
Topics: Adult; Aged; Chronic Disease; Glaucoma; Humans; Middle Aged; Pilocarpine; Propanolamines; Timolol | 1979 |
Continuous drug delivery methods reflect progress in therapy for chronic diseases.
Topics: Aged; Chronic Disease; Cytarabine; Dosage Forms; Drug Implants; Glaucoma; Humans; Injections, Intrav | 1977 |
[Problems of modern diagnosis and therapy of simple chronic glaucoma. II. Therapy].
Topics: Accommodation, Ocular; Age Factors; Chronic Disease; Glaucoma; Humans; Intraocular Pressure; Pilocar | 1975 |
The progress of the visual field in chronic simple glaucoma and ocular hypertension treated topically with pilocarpine or with timolol.
Topics: Administration, Topical; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Male; Ocular Hyperte | 1990 |
Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%.
Topics: Aged; Chronic Disease; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle | 1989 |
Intraocular pressure response to replacing pilocarpine with carbachol.
Topics: Aged; Carbachol; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; | 1988 |
Cluster headache and its variants.
Topics: Age Factors; Chronic Disease; Cluster Headache; Diagnosis, Differential; Female; Humans; Middle Aged | 1988 |
The ampicillin concentration in prostatic tissue and prostatic fluid.
Topics: Ampicillin; Animals; Biological Assay; Chronic Disease; Colon, Sigmoid; Dogs; Fistula; Humans; Male; | 1967 |
[Traumatic cervical syndromes--diagnosis, therapy and prognosis].
Topics: Adolescent; Adult; Age Factors; Atropine; Autonomic Nerve Block; Autonomic Nervous System; Cervical | 1969 |
Management of glaucoma.
Topics: Acute Disease; Carbonic Anhydrase Inhibitors; Chronic Disease; Eye; Ganglionic Blockers; Glaucoma; H | 1971 |
Trabeculectomy. A follow-up study.
Topics: Adult; Anterior Chamber; Chronic Disease; Epinephrine; Eye Injuries; Female; Follow-Up Studies; Glau | 1974 |
[Medical treatment of wide-angle chronic glaucoma].
Topics: Chronic Disease; Glaucoma; Humans; Ophthalmic Solutions; Pilocarpine; Sympatholytics; Sympathomimeti | 1974 |
[Goniospasis, a method designed to relieve canalicular blockade in primary open-angle glaucoma (author's transl)].
Topics: Aged; Anterior Chamber; Chronic Disease; Female; Glaucoma; Humans; Intraocular Pressure; Male; Micro | 1974 |
The effect of epiphrine in chronic glaucoma.
Topics: Adult; Chronic Disease; Epinephrine; Female; Glaucoma; Humans; Intraocular Pressure; Middle Aged; Ph | 1972 |
Glaucoma detection: a three-step technique.
Topics: Acute Disease; Adult; Age Factors; Aqueous Humor; Carbachol; Carbonic Anhydrase Inhibitors; Cholines | 1973 |
[Necessity and possibilities of mass screening in mucoviscidosis].
Topics: Adolescent; Age Factors; Bronchitis; Child; Child, Preschool; Chlorides; Chronic Disease; Cystic Fib | 1973 |
The use of a longer pilocarpine in the management of chronic simple glaucoma.
Topics: Aged; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Female; Glaucoma; Humans; Intra | 1974 |
Keratoconjunctivitis sicca in dogs.
Topics: Administration, Oral; Animals; Cataract; Chronic Disease; Corneal Ulcer; Dehydration; Dog Diseases; | 1971 |
Modern problems in glaucoma.
Topics: Acetazolamide; Acute Disease; Aged; Bicarbonates; Chronic Disease; Ciliary Body; Dichlorphenamide; E | 1971 |
[Bivalent vegetative glaucoma therapy].
Topics: Chronic Disease; Drug Synergism; Epinephrine; Glaucoma; Humans; Pilocarpine | 1969 |
[On the value of aceclidine in the treatment of chronic simple glaucoma as compared with pilocarpine].
Topics: Adult; Chronic Disease; Female; Glaucoma; Humans; Male; Middle Aged; Pilocarpine; Quinuclidines | 1969 |
[Retinal detachment from miotic therapy].
Topics: Adult; Age Factors; Aged; Chronic Disease; Female; Glaucoma; Humans; Male; Middle Aged; Miotics; Neo | 1970 |
[Oculocardiac reflexes in primary glaucoma].
Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure; Bradycardia; Child; Child, Preschool; Chronic | 1970 |
Systemically administered anticholinergic drugs and intraocular pressure.
Topics: Chronic Disease; Duodenal Ulcer; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Parasymp | 1970 |
Chronic angle-closure glaucoma; diagnosis and treatment in patients with angles that appear open.
Topics: Aged; Anterior Chamber; Chronic Disease; Epinephrine; Female; Glaucoma; Humans; Intraocular Pressure | 1971 |
Medical management of glaucoma.
Topics: Acute Disease; Carbachol; Carbonic Anhydrase Inhibitors; Child; Cholinesterase Inhibitors; Chronic D | 1967 |
[Treatment of open angle glaucoma (synonym: chronic simple glaucoma)].
Topics: Acetazolamide; Acetylcholine; Carbonic Anhydrase Inhibitors; Chronic Disease; Dichlorphenamide; Echo | 1968 |
Influence of drugs on aqueous flow in chronic simple glaucoma.
Topics: Acetazolamide; Adult; Aqueous Humor; Chronic Disease; Female; Glaucoma; Glycerol; Humans; Intraocula | 1968 |
[On the effect of caffeine on intraocular pressure in surgically or conservatively managed simple chronic glaucoma].
Topics: Blood Pressure; Blood Pressure Determination; Caffeine; Chronic Disease; Glaucoma; Humans; Intraocul | 1968 |
[Aceclidine in primary open angle chronic glaucoma already treated with pilocarpine: comparison between the 2 drugs].
Topics: Chronic Disease; Glaucoma; Humans; Parasympathomimetics; Pilocarpine; Tonometry, Ocular | 1968 |
[Results of medical treatment in chronic open angle glaucoma].
Topics: Aged; Carbonic Anhydrase Inhibitors; Chronic Disease; Epinephrine; Glaucoma; Humans; Hypnotics and S | 1968 |
Hepatic plexus vagectomy as an adjunct to cholecystectomy.
Topics: Acute Disease; Adult; Aged; Animals; Atropine; Bile; Biliary Tract; Biliary Tract Diseases; Cholangi | 1969 |