pilocarpine has been researched along with Chemical Dependence in 6 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 7.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 3.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Honchar, MP | 1 |
| Olney, JW | 1 |
| Sherman, WR | 1 |
| Lee, CY | 1 |
| Akera, T | 1 |
| De Young, G | 1 |
| Cross, EG | 1 |
| McBride, A | 1 |
| Turnbull, MJ | 1 |
| Thompson, HS | 1 |
| Newsome, DA | 1 |
| Loewenfeld, IE | 1 |
| Jaffe, JH | 1 |
| Sharpless, SK | 1 |
6 other studies available for pilocarpine and Chemical Dependence
| Article | Year |
|---|---|
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phospha | 1983 |
Biochemical basis for narcotic tolerance and physical dependence.
Topics: Animals; Brain; Cats; Dogs; Drug Tolerance; Feedback; Guinea Pigs; Haplorhini; Humans; Mice; Morphin | 1974 |
Stramonium psychodelia.
Topics: Adolescent; Adult; Datura stramonium; Diazepam; Hallucinogens; Humans; Male; Phenytoin; Pilocarpine; | 1969 |
The brain acetylcholine system in barbitone-dependent and withdrawn rats.
Topics: Acetylcholine; Acyltransferases; Animals; Barbiturates; Body Temperature; Body Temperature Regulatio | 1970 |
The fixed dilated pupil. Sudden iridoplegia or mydriatic drops? A simple diagnostic test.
Topics: Adie Syndrome; Adolescent; Adult; Aneurysm; Atropine; Carotid Artery Diseases; Chlorides; Diagnosis, | 1971 |
XVII. Pharmacological denervation supersensitivity in the central nervous system: a theory of physical dependence.
Topics: Animals; Autonomic Nervous System; Body Temperature; Denervation; Depression, Chemical; Drug Toleran | 1968 |