pilocarpine and Cataract studies

Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"To present the first reported case of cataract formation as a consequence of instillation of pilocarpine in an eye with a posterior chamber phakic intraocular lens (IOL)."	7.73	Cataractous changes due to posterior chamber flattening with a posterior chamber phakic intraocular lens secondary to the administration of pilocarpine. ( Benítez Del Castillo, JM; García-Feijoó, J; Maldonado, MJ; Teutsch, P, 2006)
" The aim of this study is to highlight the importance of postLPI pilocarpine use and larger LPI size as well as to share some experiences of cataract surgery in patients with ACG."	5.22	Role of pilocarpine use following laser peripheral iridotomy in eyes with refractory acute angle closure glaucoma: A case report and literature review. ( Chen, CC; Tseng, PC; Yen, CY, 2022)
"To evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM)."	3.74	The effect of cataract extraction on the contractility of ciliary muscle. ( Kee, C; Park, KA; Yun, JH, 2008)
"To present the first reported case of cataract formation as a consequence of instillation of pilocarpine in an eye with a posterior chamber phakic intraocular lens (IOL)."	3.73	Cataractous changes due to posterior chamber flattening with a posterior chamber phakic intraocular lens secondary to the administration of pilocarpine. ( Benítez Del Castillo, JM; García-Feijoó, J; Maldonado, MJ; Teutsch, P, 2006)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (80.43)	18.7374
1990's	2 (4.35)	18.2507
2000's	4 (8.70)	29.6817
2010's	2 (4.35)	24.3611
2020's	1 (2.17)	2.80

Authors	Studies
Yen, CY	1
Chen, CC	1
Tseng, PC	1
Chen, HY	1
Lin, CL	1
Kao, CH	1
Sethi, HS	1
Mayuresh, NP	1
Gupta, VS	1
Auffarth, GU	1
Maldonado, MJ	1
García-Feijoó, J	1
Benítez Del Castillo, JM	1
Teutsch, P	1
Park, KA	1
Yun, JH	1
Kee, C	1
Munger, RJ	1
Studer, JJ	1
Shaffer, RN	3
Hetherington, J	2
Tarkkanen, A	1
Karjalainen, K	1
Quigley, HA	1
Puska, P	1
Nishi, O	1
Nishi, K	1
Mano, C	1
Ichihara, M	1
Honda, T	1
Ticho, U	1
Durst, A	1
Licht, A	1
Berkowitz, S	1
Benjamin, KW	1
Ganias, F	1
Sugar, HS	1
Mayer, U	2
Holland, MG	1
Barg, TsM	1
el-Guindi, NM	1
Ayoub, MI	1
Firth, JM	1
Vucicevic, ZM	1
Tsou, KC	1
Kornzweig, AL	1
Levene, R	1
Letson, RD	1
Johnson, SB	1
Aguirre, GD	1
Rubin, LF	1
Harvey, CE	1
Hockwin, O	3
De Roetth, A	2
Hovland, KR	1
Ellis, PP	1
Morton, WR	1
Drance, SM	1
Fairclough, M	1
Abraham, SV	1
Teller, JJ	1
Rosenthal, G	1
Richards, RD	1
Hammond, A	1
Axelsson, U	4
Kanski, JJ	1
Holmberg, A	1
Boles Carenini, B	1
Orzalesi, N	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Phaco-UCP; Combined Phacoemulsification and Ultrasound Ciliary Plasty Versus Phacoemulsification Alone for Management of Coexisting Cataract and Open Angle Glaucoma[NCT04430647]				61 participants (Actual)	Interventional	2018-03-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Role of pilocarpine use following laser peripheral iridotomy in eyes with refractory acute angle closure glaucoma: A case report and literature review. Medicine, 2022, Jul-08, Volume: 101, Issue:27 Topics: Acute Disease; Cataract; Female; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Iris; Laser	2022
Toxicity of ocular medications. International ophthalmology clinics, 1979,Spring, Volume: 19, Issue:1 Topics: Adult; Aged; Alcohols; Animals; Aqueous Humor; Auditory Perception; Blood; Carbachol; Carbonic Anhyd	1979
Autonomic drugs in ophthalmology: some problems and promises. I. Directly and indirectly acting parasympathomimetic drugs. Annals of ophthalmology, 1974, Volume: 6, Issue:5 Topics: Administration, Topical; Animals; Carbachol; Cataract; Cholinesterase Inhibitors; Contact Lenses, Hy	1974
[Eye complications during use of various medicinal substances with general effects (review of the literature)]. Oftalmologicheskii zhurnal, 1969, Volume: 24, Issue:8 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Anti-Bacterial Agents; Antimalari	1969
Glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960), 1969, Volume: 81, Issue:3 Topics: Animals; Aqueous Humor; Cataract; Cataract Extraction; Cattle; Cholinesterase Inhibitors; Ciliary Bo	1969
The use of drugs in the management of strabismus. Survey of ophthalmology, 1970, Volume: 14, Issue:5 Topics: Amblyopia; Amides; Atropine; Barbiturates; Bradycardia; Cataract; Central Nervous System; Chloral Hy	1970

Article	Year
Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study. Medicine, 2019, Volume: 98, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Carbonic Anhy	2019
Intraoperative intracameral pilocarpine after capsular tension ring and capsule/iris hook insertion in pediatric eyes with subluxated cataract. Journal of cataract and refractive surgery, 2016, Volume: 42, Issue:2 Topics: Anterior Chamber; Cataract; Eye Injuries; Humans; Intraoperative Care; Lens Subluxation; Lens, Cryst	2016
[Accommodative intraocular lenses. Can synthetic lenses accommodate?]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2002, Volume: 99, Issue:11 Topics: Accommodation, Ocular; Animals; Cataract; Haplorhini; Humans; Lenses, Intraocular; Miotics; Optics a	2002
Cataractous changes due to posterior chamber flattening with a posterior chamber phakic intraocular lens secondary to the administration of pilocarpine. Ophthalmology, 2006, Volume: 113, Issue:8 Topics: Cataract; Humans; Hyperopia; Lens Implantation, Intraocular; Male; Middle Aged; Miotics; Mydriasis;	2006
The effect of cataract extraction on the contractility of ciliary muscle. American journal of ophthalmology, 2008, Volume: 146, Issue:1 Topics: Accommodation, Ocular; Aged; Anterior Chamber; Cataract; Ciliary Body; Female; Humans; Lens Implanta	2008
Comments on pathophysiology of angle changes caused by iris bowing. American journal of veterinary research, 2008, Volume: 69, Issue:5 Topics: Animals; Cataract; Cornea; Cyclopentolate; Dog Diseases; Dogs; Iris; Lens Implantation, Intraocular;	2008
Anticholinesterase drugs and cataracts. Transactions of the American Ophthalmological Society, 1966, Volume: 64 Topics: Adult; Aged; Carbachol; Cataract; Cholinesterase Inhibitors; Echothiophate Iodide; Female; Glaucoma;	1966
Cataract formation during miotic treatment for chronic open-angle glaucoma. Acta ophthalmologica, 1966, Volume: 44, Issue:6 Topics: Aged; Cataract; Echothiophate Iodide; Female; Glaucoma; Humans; Male; Middle Aged; Pilocarpine; Quat	1966
A reevaluation of glaucoma management. International ophthalmology clinics, 1984,Fall, Volume: 24, Issue:3 Topics: Acetazolamide; Cataract; Costs and Cost Analysis; Drug-Related Side Effects and Adverse Reactions; E	1984
Lens opacity in unilateral exfoliation syndrome with or without glaucoma. Acta ophthalmologica, 1994, Volume: 72, Issue:3 Topics: Aged; Aged, 80 and over; Anterior Chamber; Cataract; Exfoliation Syndrome; Glaucoma, Open-Angle; Hum	1994
Lens refilling with injectable silicone in rabbit eyes. Journal of cataract and refractive surgery, 1998, Volume: 24, Issue:7 Topics: Animals; Cataract; Cell Count; Dimethylpolysiloxanes; Endothelium, Corneal; Injections; Intraoperati	1998
Steroid-induced glaucoma and cataract in renal transplant recipients. Israel journal of medical sciences, 1977, Volume: 13, Issue:9 Topics: Administration, Oral; Adult; Azathioprine; Cataract; Female; Glaucoma; Humans; Immunosuppression The	1977
Combined thermotrabeculocanalotomy cataract extraction. Annals of ophthalmology, 1979, Volume: 11, Issue:4 Topics: Acetazolamide; Aged; Cataract; Cataract Extraction; Cautery; Eye Injuries; Glaucoma; Humans; Intraoc	1979
Low tension glaucoma: a practical approach. Annals of ophthalmology, 1979, Volume: 11, Issue:8 Topics: Aged; Cataract; Child; Epinephrine; Female; Glaucoma; Humans; Infant; Intraocular Pressure; Male; Mi	1979
[A cataract-forming substance]. Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1977, Volume: 74 Topics: Cataract; Cortisone; Glucose; Humans; Iris; Lens, Crystalline; Naphthoquinones; Pilocarpine	1977
[The action of pilocarpine on the metabolism of surviving lens epithelium and iris cells (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1976, Volume: 168, Issue:4 Topics: Cataract; Cell Survival; Cells, Cultured; Epithelial Cells; Glaucoma; Humans; Iris; Lens, Crystallin	1976
Phacolytic glaucoma. Bulletin of the Ophthalmological Society of Egypt, 1972, Volume: 65, Issue:69 Topics: Cataract; Cryosurgery; Diagnosis, Differential; Glaucoma; Humans; Intraocular Pressure; Male; Mannit	1972
The influence of miotics on the lens. Annals of ophthalmology, 1973, Volume: 5, Issue:6 Topics: Animals; Cataract; Echothiophate Iodide; Glutathione; Lens, Crystalline; Pilocarpine; Rabbits	1973
Diagnosis and treatment of common eye diseases in the aged: guidelines for the practicing physician. Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:11 Topics: Acetazolamide; Age Factors; Aged; Cataract; Cataract Extraction; Cholinesterase Inhibitors; Diabetes	1973
Combined cataract extraction and scleral cautery (includes 8-year followup in 9 cases). Annals of ophthalmology, 1971, Volume: 3, Issue:10 Topics: Acetazolamide; Cataract; Cataract Extraction; Cautery; Conjunctiva; Echothiophate Iodide; Epinephrin	1971
Keratoconjunctivitis sicca in dogs. Journal of the American Veterinary Medical Association, 1971, May-01, Volume: 158, Issue:9 Topics: Administration, Oral; Animals; Cataract; Chronic Disease; Corneal Ulcer; Dehydration; Dog Diseases;	1971
Experimental cataracts by addition of sublimal factors. Experimental eye research, 1971, Volume: 11, Issue:1 Topics: Animals; Anterior Chamber; Cataract; Diabetes Mellitus, Experimental; Galactose; Lens, Crystalline;	1971
Lens opacities in glaucoma patients on phospholine iodide therapy. Transactions of the ophthalmological societies of the United Kingdom, 1966, Volume: 86 Topics: Animals; Cataract; Cholinesterase Inhibitors; Cholinesterases; Echothiophate Iodide; Glaucoma; Human	1966
Ocular changes in renal transplant patients. American journal of ophthalmology, 1967, Volume: 63, Issue:2 Topics: Acute Kidney Injury; Adolescent; Adult; Azathioprine; Cataract; Child; Epinephrine; Female; Glaucoma	1967
Decision making in the diagnosis and therapy of the glaucomas. International ophthalmology clinics, 1969,Spring, Volume: 9, Issue:1 Topics: Adolescent; Adult; Aged; Carotid Arteries; Cataract; Cautery; Decision Making; Female; Glaucoma; Hum	1969
Influence of various miotics on cataract formation. The British journal of ophthalmology, 1969, Volume: 53, Issue:12 Topics: Adult; Age Factors; Aged; Cataract; Cholinesterase Inhibitors; Echothiophate Iodide; Glaucoma; Human	1969
[Clinical significance of the production of experimental cataract by means of addition of subliminal injuries]. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1969, Volume: 158 Suppl Topics: Animals; Cataract; Eye Injuries; Guinea Pigs; Humans; Lens, Crystalline; Naphthalenes; Pilocarpine;	1969
Comparison of cataract incidence in normal and glaucomatous population. American journal of ophthalmology, 1970, Volume: 69, Issue:3 Topics: Adult; Age Factors; Aged; California; Cataract; Cholinesterase Inhibitors; Glaucoma; Humans; Middle	1970
Long-term results of gonioplasty. American journal of ophthalmology, 1970, Volume: 70, Issue:5 Topics: Adult; Aged; Aqueous Humor; Carbonic Anhydrase Inhibitors; Cataract; Ciliary Body; Conjunctiva; Echo	1970
Dysplasia epiphysialis punctata with ocular anomalies. The British journal of ophthalmology, 1970, Volume: 54, Issue:11 Topics: Anterior Chamber; Cataract; Chondrodysplasia Punctata; Cornea; Glaucoma; Humans; Infant; Iris; Piloc	1970
Glaucoma, miotic therapy and cataract. I. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with echothiophate (Phospholine Iodide), pilocarpine or pilocarpine-eserine, and in nonglaucomatous untreated eyes with common senile catarac Acta ophthalmologica, 1968, Volume: 46, Issue:1 Topics: Adult; Aged; Cataract; Echothiophate Iodide; Female; Glaucoma; Humans; Male; Middle Aged; Physostigm	1968
Glaucoma, miotic therapy and cataract. II. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with paraoxon (Mintacol). Acta ophthalmologica, 1968, Volume: 46, Issue:1 Topics: Adult; Aged; Cataract; Female; Glaucoma; Humans; Male; Middle Aged; Parathion; Physostigmine; Piloca	1968
Miotics. The British journal of ophthalmology, 1968, Volume: 52, Issue:12 Topics: Acetylcholine; Anterior Chamber; Carbachol; Cataract; Cholinesterase Inhibitors; Cysts; Echothiophat	1968
Glaucoma, miotic therapy and cataract. 3. Visual loss due to lens changes in glaucoma eyes treated with paraoxon (Mintacol), echothiophate (phospholine iodide) or pilocarpine. Acta ophthalmologica, 1968, Volume: 46, Issue:4 Topics: Adult; Age Factors; Aged; Cataract; Cholinesterase Inhibitors; Echothiophate Iodide; Glaucoma; Human	1968
Formation of cataracts by combinations of different factors. Experimental eye research, 1969, Volume: 8, Issue:2 Topics: Animals; Anterior Chamber; Cataract; Galactose; Lens, Crystalline; Naphthalenes; Pilocarpine; Rabbit	1969
Anticholinesterase drugs and cataracts. American journal of ophthalmology, 1966, Volume: 62, Issue:4 Topics: Adult; Aged; Cataract; Echothiophate Iodide; Female; Glaucoma; Humans; Male; Middle Aged; Pilocarpin	1966
Lens opacities in glaucoma patients on phospholine iodide therapy. American journal of ophthalmology, 1966, Volume: 62, Issue:4 Topics: Animals; Cataract; Cholinesterases; Echothiophate Iodide; Enzymes; Glaucoma; Histocytochemistry; Hum	1966
The frequency of cataract after miotic therapy. Acta ophthalmologica, 1966, Volume: 44, Issue:3 Topics: Aged; Cataract; Echothiophate Iodide; Female; Glaucoma; Humans; Male; Middle Aged; Miotics; Pilocarp	1966
[Experimental research on the cataractogenic action of some miotic collyria]. Bollettino d'oculistica, 1966, Volume: 45, Issue:12 Topics: Animals; Cataract; Echothiophate Iodide; In Vitro Techniques; Lens, Crystalline; Miotics; Naphthalen	1966

pilocarpine and Cataract

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