pilocarpine has been researched along with Bronchial Hyperreactivity in 11 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Guinea pigs infected with parainfluenza virus were hyperreactive to electrical stimulation of the vagus nerves, but not to intravenous acetylcholine, indicating that hyperreactivity was due to increased release of acetylcholine from parasympathetic nerves." | 1.35 | Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. ( Fryer, AD; Jacoby, DB; Moreno-Vinasco, L; Verbout, NG, 2009) |
| "A pretreatment with pilocarpine (1-100 microM) significantly reduced, while methoctramine (1-100 microM) significantly increased contraction induced by EFS." | 1.35 | Effects of neuraminidase on equine isolated bronchi. ( Calzetta, L; Cazzola, M; Matera, MG; Page, CP; Sanduzzi, A, 2008) |
| "75-75 mg/kg, sc) shifted pilocarpine dose-response curves significantly to the right, indicating loss of neuronal M2 receptor function." | 1.33 | Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. ( Fryer, AD; Lein, PJ, 2005) |
| "In chlorpyrifos-treated animals, pilocarpine dose-response curves were shifted significantly to the right, demonstrating decreased responsiveness of neuronal M2 receptors." | 1.32 | Mechanisms of organophosphate insecticide-induced airway hyperreactivity. ( Beckles, RA; Fryer, AD; Howard, AS; Jett, DA; Lein, PJ; Yost, BL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno-Vinasco, L | 1 |
| Verbout, NG | 1 |
| Fryer, AD | 7 |
| Jacoby, DB | 1 |
| Lein, PJ | 2 |
| Howard, AS | 1 |
| Yost, BL | 2 |
| Beckles, RA | 1 |
| Jett, DA | 1 |
| McGowan, SE | 1 |
| Holmes, AJ | 1 |
| Smith, J | 1 |
| Matera, MG | 1 |
| Calzetta, L | 1 |
| Sanduzzi, A | 1 |
| Page, CP | 1 |
| Cazzola, M | 1 |
| ten Berge, RE | 1 |
| Santing, RE | 1 |
| Hamstra, JJ | 1 |
| Roffel, AF | 1 |
| Zaagsma, J | 1 |
| Gambone, LM | 1 |
| Elbon, CL | 1 |
| Schultheis, AH | 1 |
| Bassett, DJ | 1 |
| Song, P | 1 |
| Milanese, M | 1 |
| Crimi, E | 1 |
| Rehder, K | 1 |
| Brusasco, V | 1 |
| Schulman, SR | 1 |
| Canada, AT | 1 |
| Winsett, DW | 1 |
| Costa, DL | 1 |
| Gleich, GJ | 1 |
11 other studies available for pilocarpine and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Bronchial Hyperreactivity; Bronchoconstriction; Cell | 2009 |
Mechanisms of organophosphate insecticide-induced airway hyperreactivity.
Topics: Animals; Bronchial Hyperreactivity; Chlorpyrifos; Cholinesterase Inhibitors; Guinea Pigs; Insecticid | 2004 |
Retinoic acid reverses the airway hyperresponsiveness but not the parenchymal defect that is associated with vitamin A deficiency.
Topics: Animals; Antineoplastic Agents; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Elasticity; Fe | 2004 |
Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition.
Topics: Acetylcholinesterase; Animals; Brain; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Dose- | 2005 |
Effects of neuraminidase on equine isolated bronchi.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Diamines; Dose-Response Relationship, Drug; Electric St | 2008 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity | 1995 |
Ozone-induced loss of neuronal M2 muscarinic receptor function is prevented by cyclophosphamide.
Topics: Anesthesia; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Gall | 1994 |
Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function.
Topics: Acetylcholine; Animals; Blood Pressure; Bronchial Hyperreactivity; Electric Stimulation; Gallamine T | 1994 |
Allergen challenge of passively sensitized human bronchi alters M2 and beta2 receptor function.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Allergens; Animals; Asthma; Bronchi; Bronchial Hyp | 1997 |
Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs.
Topics: Acetylcholine; Acetylcholinesterase; Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchial | 1997 |
Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein.
Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Bronchoconstriction; Electric Stimul | 1999 |