pilocarpine has been researched along with Brain Injuries in 26 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 7.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 7.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 7.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 5.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "In this research, rat model of epilepsy was established by pilocarpine induction." | 3.88 | LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway. ( Fan, WF; Geng, JF; Geng, JJ; Liu, X; Liu, XZ; Zhao, HB, 2018) |
| " The results obtained for rats with mechanical brain injuries were compared with those recorded for controls and animals with pilocarpine-induced seizures." | 3.77 | X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury. ( Appel, K; Chwiej, J; Janeczko, K; Sarapata, A; Setkowicz, Z; Stegowski, Z, 2011) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 3.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "To quantify the variability in thermal pain perception of rats with chemically induced brain injury following subcutaneous lithium and pilocarpine administration, 9 female Wistar rats were subjected to a nociceptive (hotplate) paradigm." | 3.72 | Elevated nociceptive thresholds in rats with multifocal brain damage induced with single subcutaneous injections of lithium and pilocarpine. ( Galic, MA, 2004) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 3.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| "Flinch (pain) thresholds for electric current delivered to the feet were correlated with the amount of necrosis within the diencephalon and telencephalon for rats in which seizures had been induced by lithium and pilocarpine about two months before the testing." | 3.69 | Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats. ( Bureau, YR; Cook, LL; Peredery, O; Persinger, MA, 1997) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 3.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| " Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus." | 3.68 | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 1.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring." | 1.39 | Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood. ( Huang, SY; Li, BM; Li, Z; Liu, J; Qiao, NN; Sun, RP; Wang, YY; Yin, P, 2013) |
| "Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon." | 1.35 | Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. ( Cheng, JT; Huang, CC; Huang, CW; Tsai, JJ; Wu, SN, 2009) |
| "Male adult rats that displayed limbic seizures between postnatal days 18 and 21 after a single s." | 1.29 | Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: implications for early brain injuries. ( Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Reddy, DS | 1 |
| Zaayman, M | 1 |
| Kuruba, R | 1 |
| Wu, X | 1 |
| Cai, Q | 1 |
| Gan, J | 1 |
| Luo, R | 1 |
| Qu, Y | 1 |
| Li, S | 1 |
| Wan, C | 1 |
| Mu, D | 1 |
| Geng, JF | 1 |
| Liu, X | 2 |
| Zhao, HB | 1 |
| Fan, WF | 1 |
| Geng, JJ | 1 |
| Liu, XZ | 1 |
| Yin, P | 1 |
| Liu, J | 1 |
| Li, Z | 1 |
| Wang, YY | 1 |
| Qiao, NN | 1 |
| Huang, SY | 1 |
| Li, BM | 1 |
| Sun, RP | 1 |
| Dong, Y | 1 |
| Wang, S | 1 |
| Zhang, T | 1 |
| Zhao, X | 1 |
| Cao, L | 1 |
| Chi, Z | 1 |
| Duffy, BA | 1 |
| Chun, KP | 1 |
| Ma, D | 1 |
| Lythgoe, MF | 1 |
| Scott, RC | 1 |
| Biagini, G | 1 |
| Baldelli, E | 1 |
| Longo, D | 1 |
| Contri, MB | 1 |
| Guerrini, U | 1 |
| Sironi, L | 1 |
| Gelosa, P | 1 |
| Zini, I | 1 |
| Ragsdale, DS | 1 |
| Avoli, M | 1 |
| LEVIN, SL | 1 |
| Lagace, N | 1 |
| St-Pierre, LS | 1 |
| Persinger, MA | 5 |
| Huang, CW | 1 |
| Cheng, JT | 1 |
| Tsai, JJ | 1 |
| Wu, SN | 1 |
| Huang, CC | 1 |
| Gurkoff, GG | 1 |
| Giza, CC | 1 |
| Shin, D | 1 |
| Auvin, S | 1 |
| Sankar, R | 1 |
| Hovda, DA | 1 |
| Chwiej, J | 1 |
| Sarapata, A | 1 |
| Janeczko, K | 2 |
| Stegowski, Z | 1 |
| Appel, K | 1 |
| Setkowicz, Z | 2 |
| Galic, MA | 1 |
| Shetty, AK | 1 |
| Hattiangady, B | 1 |
| Ferrari, D | 1 |
| Cysneiros, RM | 1 |
| Scorza, CA | 1 |
| Arida, RM | 1 |
| Cavalheiro, EA | 1 |
| de Almeida, AC | 1 |
| Scorza, FA | 1 |
| Sun, H | 1 |
| Huang, Y | 1 |
| Yu, X | 1 |
| Li, Y | 1 |
| Yang, J | 1 |
| Li, R | 1 |
| Deng, Y | 1 |
| Zhao, G | 1 |
| Kostakos, M | 1 |
| Peredery, O | 2 |
| Bureau, YR | 2 |
| Meller, D | 1 |
| Bellander, BM | 1 |
| Schmidt-Kastner, R | 1 |
| Ingvar, M | 1 |
| Wasterlain, CG | 1 |
| Cook, LL | 2 |
| Motte, J | 1 |
| Fernandes, MJ | 1 |
| Baram, TZ | 1 |
| Nehlig, A | 1 |
| Desjardins, D | 1 |
| Parker, G | 1 |
| Norton, L | 1 |
| Greer, J | 1 |
| Eiseman, B | 1 |
| Beattie, CW | 1 |
| Chernov, HI | 1 |
| Bernard, PS | 1 |
| Glenny, FH | 1 |
2 reviews available for pilocarpine and Brain Injuries
| Article | Year |
|---|---|
Concise review: prospects of stem cell therapy for temporal lobe epilepsy.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Cell Differentiation; Disease Models, Animal; | 2007 |
Recurrent seizures in the developing brain are harmful.
Topics: Adult; Animals; Brain; Brain Injuries; Child; Disease Models, Animal; Entorhinal Cortex; Epilepsy; H | 1997 |
24 other studies available for pilocarpine and Brain Injuries
| Article | Year |
|---|---|
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Topics: Amygdala; Animals; Biomarkers; Brain Injuries; Cognitive Dysfunction; Lithium; Male; Necrosis; Neuro | 2017 |
LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Brain Injuries; Cells, Cultured; Epilepsy; Gene E | 2018 |
Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Disease Susceptibili | 2013 |
Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy.
Topics: Animals; Antioxidants; Ascorbic Acid; Autophagy; Brain; Brain Injuries; Lipid Peroxidation; Male; Ma | 2013 |
Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries; Cerebral Cortex; Dexamethasone; Dise | 2014 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
[Pilocarpine secretion of human salivary glands in various brain injuries].
Topics: Brain Injuries; Humans; Pilocarpine; Salivary Glands | 1947 |
Attenuation of epilepsy-induced brain damage in the temporal cortices of rats by exposure to LTP-patterned magnetic fields.
Topics: Animals; Brain Injuries; Dose-Response Relationship, Radiation; Epilepsy; Lithium Chloride; Long-Ter | 2009 |
Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biophysics; Blood Glucose; Brain Injuries; Co | 2009 |
Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat.
Topics: Aging; Animals; Brain Injuries; Cell Count; Cell Death; Hippocampus; Immunohistochemistry; Male; Neu | 2009 |
X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury.
Topics: Animals; Brain; Brain Injuries; In Vitro Techniques; Male; Pilocarpine; Rats; Seizures; Spectrometry | 2011 |
Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Disease Susceptibility; Drug Res | 2003 |
Elevated nociceptive thresholds in rats with multifocal brain damage induced with single subcutaneous injections of lithium and pilocarpine.
Topics: Acepromazine; Animals; Antipsychotic Agents; Brain Injuries; Epilepsy, Temporal Lobe; Female; Inject | 2004 |
Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins.
Topics: Analysis of Variance; Animals; Brain Injuries; Calbindin 2; Cell Count; Disease Models, Animal; Epil | 2008 |
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.
Topics: Animals; Benzamides; Blotting, Western; Brain Injuries; CD40 Antigens; Central Nervous System Diseas | 2008 |
Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: implications for early brain injuries.
Topics: Animals; Brain Injuries; Limbic System; Lithium; Male; Memory; Memory Disorders; Memory, Short-Term; | 1993 |
Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Topics: Acepromazine; Animals; Body Temperature Regulation; Brain Injuries; Chlorides; Hypothermia; Limbic S | 1993 |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates; | 1993 |
Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain; Brain Injuries; Disease Models, Animal; Electroshoc | 1997 |
Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.
Topics: Animals; Behavior, Animal; Brain Injuries; Electroencephalography; Lithium; Male; Neurons; Pilocarpi | 1998 |
Agonistic behavior in groups of limbic epileptic male rats: pattern of brain damage and moderating effects from normal rats.
Topics: Agonistic Behavior; Animals; Antimanic Agents; Behavior, Animal; Brain Injuries; Cerebral Cortex; Co | 2001 |
Gastric secretory response to head injury.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Animals; Brain Injuries; Child; Craniocerebral Tra | 1970 |
Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Brain; Brain Injuries; Cerebral Ventricles; Chlo | 1969 |