pilocarpine has been researched along with Brain Edema in 9 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 7.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 5.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| " In the present study, we investigated the roles of ER stress in vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced status epilepticus (SE)." | 3.81 | Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. ( Hyun, HW; Kim, JE; Kim, JY; Ko, AR, 2015) |
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 3.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| "Meanwhile, cerebral edema, as well as neuronal loss, was decreased in several brain areas in the GBC group." | 1.46 | Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. ( Gu, Y; Hu, Y; Huang, H; Huang, K; Ji, Z; Lin, Z; Pan, S; Wang, S; Wu, Y; Yang, T, 2017) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 1.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "Rats were observed for seizure activity for 2 h, survivors were killed 24 h later and edema was measured in samples from parietal and piriform cortices, dorsal thalmus, and hippocampus." | 1.28 | Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats. ( Nelson, SR; Padzernik, TL; Terry, JB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, Z | 2 |
| Huang, H | 1 |
| Gu, Y | 1 |
| Huang, K | 1 |
| Hu, Y | 1 |
| Ji, Z | 1 |
| Wu, Y | 1 |
| Wang, S | 1 |
| Yang, T | 2 |
| Pan, S | 2 |
| Xie, L | 1 |
| Wang, Y | 1 |
| Duffy, BA | 1 |
| Chun, KP | 1 |
| Ma, D | 1 |
| Lythgoe, MF | 1 |
| Scott, RC | 1 |
| Itoh, K | 1 |
| Inamine, M | 1 |
| Oshima, W | 1 |
| Kotani, M | 1 |
| Chiba, Y | 1 |
| Ueno, M | 1 |
| Ishihara, Y | 1 |
| Ko, AR | 1 |
| Kim, JY | 1 |
| Hyun, HW | 1 |
| Kim, JE | 4 |
| Kim, DS | 2 |
| Min, SJ | 1 |
| Kim, MJ | 2 |
| Kang, TC | 3 |
| Yeo, SI | 1 |
| Ryu, HJ | 2 |
| Jo, SM | 1 |
| Choi, SY | 1 |
| Terry, JB | 1 |
| Padzernik, TL | 1 |
| Nelson, SR | 1 |
9 other studies available for pilocarpine and Brain Edema
| Article | Year |
|---|---|
Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cognition Disorders; Disease Models, Animal; Gene | 2017 |
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anticonvulsants; Apoptosis; Blood-Brain B | 2017 |
Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries; Cerebral Cortex; Dexamethasone; Dise | 2014 |
Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam.
Topics: Animals; Anticonvulsants; Brain Edema; Cell Death; Disease Models, Animal; Levetiracetam; Magnetic R | 2015 |
Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Caveolin 1; Cerebral Cortex; Disease Models, Animal; Endo | 2015 |
Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, U | 2016 |
Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Calcium-Binding Proteins; Cell Count; Cerebral Cortex | 2010 |
Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus.
Topics: Animals; Antigens, Surface; Brain Edema; Cell Count; Chemokine CXCL2; Disease Models, Animal; Endoth | 2012 |
Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats.
Topics: Animals; Brain; Brain Edema; Chlorides; Isoflurophate; Lithium; Lithium Chloride; Male; Organ Specif | 1990 |