pilocarpine has been researched along with Brain Damage, Chronic in 13 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 7.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "Multivariate analyses between conditioned taste aversion (CTA) and radial maze acquisition (RMA) scores and percentages of neuronal dropout within thalamic and telencephalic structures were completed for rats in which overt seizures had been evoked following a single systemic injection of lithium/pilocarpine." | 3.69 | Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 3.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| "Although longer periods of seizures consistently result in brain damage, it has previously not been clear whether brief single or intermittent seizures lead to cell death." | 2.41 | Neuronal apoptosis after brief and prolonged seizures. ( Bengzon, J; Ekdahl, CT; Lindvall, O; Mohapel, P, 2002) |
| "Many animals developed seizures of varying severity and length." | 1.32 | Neuropathology of seizures in the immature rabbit. ( Brucklacher, R; Housman, C; Towfighi, J; Vannucci, RC, 2004) |
| "2." | 1.30 | MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats. ( Choi, BJ; Chou, JY; Kim, CY; Kim, SK; Lee, KH; Lee, MG, 1997) |
| "after seizure induction than for those who received the same field over the left hemisphere or that had been exposed to reference conditions." | 1.29 | Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury. ( Cook, LL; Persinger, MA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomé, Ada R | 1 |
| Ferreira, PM | 1 |
| Freitas, RM | 1 |
| Bengzon, J | 1 |
| Mohapel, P | 1 |
| Ekdahl, CT | 1 |
| Lindvall, O | 1 |
| Persinger, MA | 4 |
| St-Pierre, LS | 1 |
| Krsek, P | 1 |
| Mikulecká, A | 1 |
| Druga, R | 1 |
| Kubová, H | 1 |
| Hlinák, Z | 1 |
| Suchomelová, L | 1 |
| Mares, P | 1 |
| Towfighi, J | 1 |
| Housman, C | 1 |
| Brucklacher, R | 1 |
| Vannucci, RC | 1 |
| Chakir, A | 1 |
| Fabene, PF | 1 |
| Ouazzani, R | 1 |
| Bentivoglio, M | 1 |
| Bureau, YR | 2 |
| Peredery, O | 2 |
| Kostakos, M | 1 |
| Falter, H | 1 |
| Cook, LL | 1 |
| Lee, MG | 1 |
| Chou, JY | 1 |
| Lee, KH | 1 |
| Choi, BJ | 1 |
| Kim, SK | 1 |
| Kim, CY | 1 |
| Corso, TD | 1 |
| Sesma, MA | 1 |
| Tenkova, TI | 1 |
| Der, TC | 1 |
| Wozniak, DF | 1 |
| Farber, NB | 1 |
| Olney, JW | 1 |
| Schmidt-Kastner, R | 1 |
| Ingvar, M | 1 |
| Boyd, EM | 1 |
2 reviews available for pilocarpine and Brain Damage, Chronic
| Article | Year |
|---|---|
Neuronal apoptosis after brief and prolonged seizures.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Dentate Gyrus; Disease Models, Animal; Kainic Acid; Neuro | 2002 |
Encephalopathy in toxicity tests on laboratory animals.
Topics: Animals; Aspirin; Atropine; Behavior, Animal; Brain Damage, Chronic; Brain Diseases; Caffeine; Casei | 1971 |
11 other studies available for pilocarpine and Brain Damage, Chronic
| Article | Year |
|---|---|
Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Brain Damage, Chronic; Hippocampus; Male; Mu | 2010 |
The brain matrix and multifocal brain damage following a single injection of ketamine in young adult rats: conspicuous changes in old age.
Topics: Acepromazine; Age Factors; Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Ketamine; | 2002 |
Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats.
Topics: Animals; Arousal; Behavior, Animal; Brain; Brain Damage, Chronic; Brain Mapping; Calbindins; Convuls | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypote | 2004 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory.
Topics: Animals; Avoidance Learning; Brain Damage, Chronic; Brain Mapping; Conditioning, Classical; Dose-Res | 1994 |
Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Topics: Acetylcholine; Aggression; Animals; Association Learning; Avoidance Learning; Brain; Brain Damage, C | 1993 |
Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury.
Topics: Acetates; Amines; Animals; Anticonvulsants; Appetitive Behavior; Brain Damage, Chronic; Cholinergic | 1996 |
MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.
Topics: Animals; Brain Damage, Chronic; Dizocilpine Maleate; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; | 1997 |
Multifocal brain damage induced by phencyclidine is augmented by pilocarpine.
Topics: Animals; Brain; Brain Damage, Chronic; Dose-Response Relationship, Drug; Drug Synergism; Female; Ner | 1997 |
Laminar damage of neurons and astrocytes in neocortex and hippocampus of rat after long-lasting status epilepticus induced by pilocarpine.
Topics: Animals; Astrocytes; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Glial Fibrillary Acidic | 1996 |