pilocarpine has been researched along with Bipolar Disorder in 9 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 6.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Pilocarpine was administered after 1 week of treatment, and behavior including seizures was assessed using rating scale." | 5.42 | Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder. ( Agam, G; Belmaker, RH; Bersudsky, Y; Shtein, L, 2015) |
| "Behaviors of calcium/calmodulin-dependent protein kinase II alpha (α-CaMKII) heterozygous knock-out (KO) mice, which are a representative bipolar disorder/schizophrenia model displaying iDG, and pilocarpine-treated mice, which are a representative epilepsy model, were tested followed by quantitative polymerase chain reaction (qPCR)/immunohistochemistry for mRNA/protein expression associated with an iDG phenotype." | 3.79 | The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease. ( Chen, Q; Gross, AK; Hagihara, H; Heusner, CL; Kobayashi, K; Kogan, JH; Matsumoto, M; Miyakawa, T; Miyake, S; Shin, R; Tajinda, K; Tamura, K; Walton, NM, 2013) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 2.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "Pilocarpine was administered after 1 week of treatment, and behavior including seizures was assessed using rating scale." | 1.42 | Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder. ( Agam, G; Belmaker, RH; Bersudsky, Y; Shtein, L, 2015) |
| "Valproic acid is an effective treatment for mania." | 1.30 | Sodium valproate increases pupillary responsiveness to a cholinergic agonist in responders with mania. ( DeMet, EM; Sokolski, KN, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shin, R | 1 |
| Kobayashi, K | 1 |
| Hagihara, H | 1 |
| Kogan, JH | 1 |
| Miyake, S | 1 |
| Tajinda, K | 1 |
| Walton, NM | 1 |
| Gross, AK | 1 |
| Heusner, CL | 1 |
| Chen, Q | 1 |
| Tamura, K | 1 |
| Miyakawa, T | 1 |
| Matsumoto, M | 1 |
| Shtein, L | 1 |
| Agam, G | 1 |
| Belmaker, RH | 2 |
| Bersudsky, Y | 2 |
| Sokolski, KN | 3 |
| DeMet, EM | 3 |
| Miller, EB | 1 |
| Pain, RW | 1 |
| Skripal, PJ | 1 |
| Olfson, M | 1 |
| Sherman, WR | 1 |
| Gish, BG | 1 |
| Honchar, MP | 1 |
| Munsell, LY | 1 |
1 review available for pilocarpine and Bipolar Disorder
| Article | Year |
|---|---|
Lithium-pilocarpine seizures as a model for lithium action in mania.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Inositol; Limbic System | 2007 |
8 other studies available for pilocarpine and Bipolar Disorder
| Article | Year |
|---|---|
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.
Topics: Animals; Behavioral Symptoms; Biomarkers; Bipolar Disorder; Calbindin 2; Dentate Gyrus; Disease Mode | 2013 |
Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder.
Topics: Animals; Antimanic Agents; Behavior; Behavior, Animal; Bipolar Disorder; Diet; Enzyme Inhibitors; In | 2015 |
Pupillary cholinergic sensitivity to pilocarpine increases in manic lithium responders.
Topics: Administration, Topical; Adult; Antimanic Agents; Bipolar Disorder; Cholinergic Agonists; Humans; Li | 1999 |
Sodium valproate increases pupillary responsiveness to a cholinergic agonist in responders with mania.
Topics: Adult; Bipolar Disorder; Cholinergic Agonists; Humans; Male; Middle Aged; Muscarinic Agonists; Piloc | 1999 |
Cholinergic sensitivity predicts severity of mania.
Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Miotics; Musca | 2000 |
Sweat lithium in manic-depression.
Topics: Bipolar Disorder; Humans; Lithium; Pilocarpine; Sweat; Sweating | 1978 |
An old treatment for mania.
Topics: Bipolar Disorder; England; History, 19th Century; Humans; Male; Pilocarpine; Psychiatry | 1987 |
Effects of lithium on phosphoinositide metabolism in vivo.
Topics: Animals; Bipolar Disorder; Brain; Cerebral Cortex; Guinea Pigs; Humans; In Vitro Techniques; Kinetic | 1986 |